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Gewerbestrasse 25 CH-4123 AllschwilXenometrix together with its partners (GLP contract research laboratories) offers you a full range of studies and services for all your registration, notification purposes for chemicals, agrochemicals, veterinary medicinal products, biocides, medical devices. For each particular product an individual strategy is developed, based upon the actual legal requirements. All necessary studies are carried out: In vitro Toxicology, Mutagenicity (Screening and GLP), Genotoxicity, In vitro Micronucleus Test, Chromosomal Aberrations, Endocrine Disruptors, Cytotoxicity, Ecotoxicology, Biodegradability, Environmental Fate, Physico-chemical Properties, Analytical Chemistry. Xenometrix is also specialized in the production and sales of ready-to-use miniaturized Ames Test kits, i.e., Ames II, Ames MPF PENTA 1 and 2, Ames MPF 98/100 Aqua, MicroAmes24, and NanoAmes, Rapid MicroNucleus MoA. The assays come as a complete kit, are standardized and quality controlled to enable the customer a faster set-up of the Ames assay and to allow higher reproducibility due to standardisation. They are run in a liquid format on 384 well plates and can be automated. The assay system is a miniaturized Ames test listed in the ICH M7 guideline and is a version of the Ames fluctuation test cited in the OECD / FDA guidelines. The miniaturized Ames test system uses 11 times less postmitochondrial rat liver S9 fraction as compared to the agar plate method and therefore contributes substantially to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. Several publications showing a high concordance with the agar plate method are available. The Ames MPF kits are the best validated miniaturized test systems in the field of mutagenicity assays, a large database is available on this homepage. Another product range of Xenometrix are the bioassay kits "XenoScreen" for the detection of endocrine disruptor chemicals (EDCs) activating or inhibiting the human estrogen and androgen receptors, agonistic and antagonistic action. The kits are quality controlled and standardized. A broad selection of ex vivo human and animal skin samples are available for skin absorption or penetration studies: Abdominal full skin without adipose tissue, dermatomed skins, isolated stratum corneum, facial skins, porcine buccal mucosas, porcine ear skins, single bovine nail sheets and also Franz Diffusion Cells. The high quality skins are prepared under GLP standards within a maximum of 8 hours after cosmetic surgery. Skin samples are collected from donors who gave their informed consent. Ex vivo human skins are an excellent alternative to animal testing and contribute to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. They are used to test chemicals, pharmaceuticals, cosmetics, pesticides for dermal absorption or skin penetration : Selecting drug candidates for dermal application, characterization of topical dosage forms, quality assessment, safety evaluation of chemicals or pesticides, safety evaluation of cosmetic active ingredients or selecting a suitable vehicle.
Im Entenbad 4 Lörrach, 79541 GermanyXenometrix together with its partners (GLP contract research laboratories) offers you a full range of studies and services for all your registration, notification purposes for chemicals, agrochemicals, veterinary medicinal products, biocides, medical devices. For each particular product an individual strategy is developed, based upon the actual legal requirements. All necessary studies are carried out: In vitro Toxicology, Mutagenicity (Screening and GLP), Genotoxicity, In vitro Micronucleus Test, Chromosomal Aberrations, Endocrine Disruptors, Cytotoxicity, Ecotoxicology, Biodegradability, Environmental Fate, Physico-chemical Properties, Analytical Chemistry. Xenometrix is also specialized in the production and sales of ready-to-use miniaturized Ames Test kits, i.e., Ames II, Ames MPF PENTA 1 and 2, Ames MPF 98/100 Aqua, MicroAmes24, and NanoAmes, Rapid MicroNucleus MoA. The assays come as a complete kit, are standardized and quality controlled to enable the customer a faster set-up of the Ames assay and to allow higher reproducibility due to standardisation. They are run in a liquid format on 384 well plates and can be automated. The assay system is a miniaturized Ames test listed in the ICH M7 guideline and is a version of the Ames fluctuation test cited in the OECD / FDA guidelines. The miniaturized Ames test system uses 11 times less postmitochondrial rat liver S9 fraction as compared to the agar plate method and therefore contributes substantially to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. Several publications showing a high concordance with the agar plate method are available. The Ames MPF kits are the best validated miniaturized test systems in the field of mutagenicity assays, a large database is available on this homepage. Another product range of Xenometrix are the bioassay kits "XenoScreen" for the detection of endocrine disruptor chemicals (EDCs) activating or inhibiting the human estrogen and androgen receptors, agonistic and antagonistic action. The kits are quality controlled and standardized. A broad selection of ex vivo human and animal skin samples are available for skin absorption or penetration studies: Abdominal full skin without adipose tissue, dermatomed skins, isolated stratum corneum, facial skins, porcine buccal mucosas, porcine ear skins, single bovine nail sheets and also Franz Diffusion Cells. The high quality skins are prepared under GLP standards within a maximum of 8 hours after cosmetic surgery. Skin samples are collected from donors who gave their informed consent. Ex vivo human skins are an excellent alternative to animal testing and contribute to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. They are used to test chemicals, pharmaceuticals, cosmetics, pesticides for dermal absorption or skin penetration : Selecting drug candidates for dermal application, characterization of topical dosage forms, quality assessment, safety evaluation of chemicals or pesticides, safety evaluation of cosmetic active ingredients or selecting a suitable vehicle.
Gewerbestrasse 25 Allschwil, 4123 SwitzerlandXenometrix together with its partners (GLP contract research laboratories) offers you a full range of studies and services for all your registration, notification purposes for chemicals, agrochemicals, veterinary medicinal products, biocides, medical devices. For each particular product an individual strategy is developed, based upon the actual legal requirements. All necessary studies are carried out: In vitro Toxicology, Mutagenicity (Screening and GLP), Genotoxicity, In vitro Micronucleus Test, Chromosomal Aberrations, Endocrine Disruptors, Cytotoxicity, Ecotoxicology, Biodegradability, Environmental Fate, Physico-chemical Properties, Analytical Chemistry. Xenometrix is also specialized in the production and sales of ready-to-use miniaturized Ames Test kits, i.e., Ames II, Ames MPF PENTA 1 and 2, Ames MPF 98/100 Aqua, MicroAmes24, and NanoAmes, Rapid MicroNucleus MoA. The assays come as a complete kit, are standardized and quality controlled to enable the customer a faster set-up of the Ames assay and to allow higher reproducibility due to standardisation. They are run in a liquid format on 384 well plates and can be automated. The assay system is a miniaturized Ames test listed in the ICH M7 guideline and is a version of the Ames fluctuation test cited in the OECD / FDA guidelines. The miniaturized Ames test system uses 11 times less postmitochondrial rat liver S9 fraction as compared to the agar plate method and therefore contributes substantially to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. Several publications showing a high concordance with the agar plate method are available. The Ames MPF kits are the best validated miniaturized test systems in the field of mutagenicity assays, a large database is available on this homepage. Another product range of Xenometrix are the bioassay kits "XenoScreen" for the detection of endocrine disruptor chemicals (EDCs) activating or inhibiting the human estrogen and androgen receptors, agonistic and antagonistic action. The kits are quality controlled and standardized. A broad selection of ex vivo human and animal skin samples are available for skin absorption or penetration studies: Abdominal full skin without adipose tissue, dermatomed skins, isolated stratum corneum, facial skins, porcine buccal mucosas, porcine ear skins, single bovine nail sheets and also Franz Diffusion Cells. The high quality skins are prepared under GLP standards within a maximum of 8 hours after cosmetic surgery. Skin samples are collected from donors who gave their informed consent. Ex vivo human skins are an excellent alternative to animal testing and contribute to the reduction of sacrificed test animals fully in line with 3R – Replace, Reduce, Refine. They are used to test chemicals, pharmaceuticals, cosmetics, pesticides for dermal absorption or skin penetration : Selecting drug candidates for dermal application, characterization of topical dosage forms, quality assessment, safety evaluation of chemicals or pesticides, safety evaluation of cosmetic active ingredients or selecting a suitable vehicle.
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