1300 York Avenue New York, NY, 10065 United StatesThe Abby and Howard P. Milstein Chemistry Core Facility (MCCF) was established in 2006 through the generosity of Weill Cornell Overseer Howard P. Milstein. Though primarily designed to assist with synthetic chemistry, our expertise and equipment allows us to provide essential analytical services as well. Major equipment includes UPLC/MS, with mass detection up to 3000 amu, preparative HPLC/MS, preparative HPLC, GC/MS, IR, automated microwave synthesizer, and automated chromatography instrumentation. The recent acquisition of an Agilent RapidFire LC/MS system greatly expands our analytical capabilities. For example, we are now able to offer fragmentation analysis of analytes using the triple quadrupole mass spectrometer. Our work is accomplished through the design and execution of efficient and economical synthesis of chemicals that are either not readily available through commercial vendors, or are prohibitively expensive. Such compounds may be known in the literature, or entirely novel, and can be generated in virtually any quantity desired, from sub-milligram quantities to tens of grams, using equipment currently within the lab. Each molecule generated is fully characterized by modern analytical techniques. Synthetic projects generally fall within two subcategories: • synthesis of a single compound that is known in the literature, or obtained from a chemical screen • synthesis of compounds with unknown utility, but are predicted to have desirable properties Analytical projects also generally fall within three subcategories: • identification of unknown and/or known molecular entities • evaluation of extracts from cellular assays • analysis of biological extracts, serum, or plasma The Milstein Chemistry Core Facility is supported by the Howard and Abby Milstein Foundation through its medical philanthropy. To learn more about this charity, please visit the Howard and Abby Milstein Foundation website.