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4100 John R Detroit, Michigan 48201Mission of the Core The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by Distributing cancer models developed at Karmanos Cancer Institute Conducting in vivo testing of novel therapeutics Assisting investigators in many aspects of small animal research AMTEC interfaces with appropriate cores for follow-up sample analysis. Core Services Available Cancer Models Developed in KCI Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples. BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel - 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2 Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series in vivo Testing of Novel Therapeutics Pre-clinical testing of experimental therapeutics Generate documents for publication, grant/contract application and intellectual property application Generate new drug resistant or genetically targeted tumor lines Generate new xenograft models from human tissues Assist Investigators in All Aspects of Small Animal Research Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies Breeding and genotyping of genetically modified animals Small animal whole body Irradiation, surgery, tissue collection Train lab personnel for specialized techniques Provide consultation to generate genetically modified mouse strains
4100 John R Detroit, MI, 48201 United StatesMission of the Core The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by Distributing cancer models developed at Karmanos Cancer Institute Conducting in vivo testing of novel therapeutics Assisting investigators in many aspects of small animal research AMTEC interfaces with appropriate cores for follow-up sample analysis. Core Services Available Cancer Models Developed in KCI Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples. BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel - 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2 Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series in vivo Testing of Novel Therapeutics Pre-clinical testing of experimental therapeutics Generate documents for publication, grant/contract application and intellectual property application Generate new drug resistant or genetically targeted tumor lines Generate new xenograft models from human tissues Assist Investigators in All Aspects of Small Animal Research Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies Breeding and genotyping of genetically modified animals Small animal whole body Irradiation, surgery, tissue collection Train lab personnel for specialized techniques Provide consultation to generate genetically modified mouse strains
4100 John R Detroit, Michigan, 48201 United StatesMission of the Core The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by Distributing cancer models developed at Karmanos Cancer Institute Conducting in vivo testing of novel therapeutics Assisting investigators in many aspects of small animal research AMTEC interfaces with appropriate cores for follow-up sample analysis. Core Services Available Cancer Models Developed in KCI Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples. BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel - 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2 Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series in vivo Testing of Novel Therapeutics Pre-clinical testing of experimental therapeutics Generate documents for publication, grant/contract application and intellectual property application Generate new drug resistant or genetically targeted tumor lines Generate new xenograft models from human tissues Assist Investigators in All Aspects of Small Animal Research Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies Breeding and genotyping of genetically modified animals Small animal whole body Irradiation, surgery, tissue collection Train lab personnel for specialized techniques Provide consultation to generate genetically modified mouse strains
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