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6190 Cornerstone Ct E Ste 103 San Diego, CA, 92121 4701 United StatesVala Sciences provides high‑content phenotypic screening services with deep expertise in hiPSC‑based models of human cardiac and central nervous system diseases. Our automated Kinetic Image Cytometer (KIC®), paired with Vala’s CyteSeer® analytics platform, resolves billions of single‑cell data points from both fixed and live cells. This big‑data approach reveals mechanistic insights into disease biology and delivers industry‑leading in vitro predictivity of human clinical responses. We partner with biotechnology and pharmaceutical teams to develop disease‑modeling, drug‑discovery, and preclinical efficacy and safety‑toxicology assays across the following areas: Cardiac assays (adult mammalian and hiPSC‑cardiomyocytes, healthy and patient‑derived): Calcium flux, contractility, mitochondrial membrane potential, and voltage action potentials for single‑cell optical electrophysiology and cardiotoxicity profiling Neuronal assays (hiPSC‑neurons, healthy and patient‑derived): Calcium and voltage transients, neurite morphology, synapse density, and neurotoxicity endpoints Microglial assays (hiPSC‑microglia): Morphology, phagocytosis, and neuron–microglia co‑culture interactions Metabolic assays: Adipogenesis and lipolysis Cell health and stress pathways: Apoptosis, autophagy, mitochondrial function, and related phenotypic readouts Protein biomarker imaging: Quantification of protein expression within nuclei, membranes, and subcellular organelles
6370 Nancy Ridge Dr. #106 San Diego, CA, 92121 United StatesVala Sciences provides high‑content phenotypic screening services with deep expertise in hiPSC‑based models of human cardiac and central nervous system diseases. Our automated Kinetic Image Cytometer (KIC®), paired with Vala’s CyteSeer® analytics platform, resolves billions of single‑cell data points from both fixed and live cells. This big‑data approach reveals mechanistic insights into disease biology and delivers industry‑leading in vitro predictivity of human clinical responses. We partner with biotechnology and pharmaceutical teams to develop disease‑modeling, drug‑discovery, and preclinical efficacy and safety‑toxicology assays across the following areas: Cardiac assays (adult mammalian and hiPSC‑cardiomyocytes, healthy and patient‑derived): Calcium flux, contractility, mitochondrial membrane potential, and voltage action potentials for single‑cell optical electrophysiology and cardiotoxicity profiling Neuronal assays (hiPSC‑neurons, healthy and patient‑derived): Calcium and voltage transients, neurite morphology, synapse density, and neurotoxicity endpoints Microglial assays (hiPSC‑microglia): Morphology, phagocytosis, and neuron–microglia co‑culture interactions Metabolic assays: Adipogenesis and lipolysis Cell health and stress pathways: Apoptosis, autophagy, mitochondrial function, and related phenotypic readouts Protein biomarker imaging: Quantification of protein expression within nuclei, membranes, and subcellular organelles
6370 Nancy Ridge Drive #106 San Diego, CA 92121 USAVala Sciences provides high‑content phenotypic screening services with deep expertise in hiPSC‑based models of human cardiac and central nervous system diseases. Our automated Kinetic Image Cytometer (KIC®), paired with Vala’s CyteSeer® analytics platform, resolves billions of single‑cell data points from both fixed and live cells. This big‑data approach reveals mechanistic insights into disease biology and delivers industry‑leading in vitro predictivity of human clinical responses. We partner with biotechnology and pharmaceutical teams to develop disease‑modeling, drug‑discovery, and preclinical efficacy and safety‑toxicology assays across the following areas: Cardiac assays (adult mammalian and hiPSC‑cardiomyocytes, healthy and patient‑derived): Calcium flux, contractility, mitochondrial membrane potential, and voltage action potentials for single‑cell optical electrophysiology and cardiotoxicity profiling Neuronal assays (hiPSC‑neurons, healthy and patient‑derived): Calcium and voltage transients, neurite morphology, synapse density, and neurotoxicity endpoints Microglial assays (hiPSC‑microglia): Morphology, phagocytosis, and neuron–microglia co‑culture interactions Metabolic assays: Adipogenesis and lipolysis Cell health and stress pathways: Apoptosis, autophagy, mitochondrial function, and related phenotypic readouts Protein biomarker imaging: Quantification of protein expression within nuclei, membranes, and subcellular organelles
6370 Nancy Ridge Dr Ste 106 San Diego, CA, 92121 United StatesVala Sciences provides high‑content phenotypic screening services with deep expertise in hiPSC‑based models of human cardiac and central nervous system diseases. Our automated Kinetic Image Cytometer (KIC®), paired with Vala’s CyteSeer® analytics platform, resolves billions of single‑cell data points from both fixed and live cells. This big‑data approach reveals mechanistic insights into disease biology and delivers industry‑leading in vitro predictivity of human clinical responses. We partner with biotechnology and pharmaceutical teams to develop disease‑modeling, drug‑discovery, and preclinical efficacy and safety‑toxicology assays across the following areas: Cardiac assays (adult mammalian and hiPSC‑cardiomyocytes, healthy and patient‑derived): Calcium flux, contractility, mitochondrial membrane potential, and voltage action potentials for single‑cell optical electrophysiology and cardiotoxicity profiling Neuronal assays (hiPSC‑neurons, healthy and patient‑derived): Calcium and voltage transients, neurite morphology, synapse density, and neurotoxicity endpoints Microglial assays (hiPSC‑microglia): Morphology, phagocytosis, and neuron–microglia co‑culture interactions Metabolic assays: Adipogenesis and lipolysis Cell health and stress pathways: Apoptosis, autophagy, mitochondrial function, and related phenotypic readouts Protein biomarker imaging: Quantification of protein expression within nuclei, membranes, and subcellular organelles
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