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2760 West 3rd Ave Vancouver, British Columbia, V6K1M5 CanadaUnpuzzle HEOR is a specialist consultancy focused on solving complex evidence and methodological challenges in oncology and other therapeutic areas. We support pharmaceutical and biotech clients with advanced methods including indirect treatment comparisons (ITCs), such as network meta-analysis (NMA), multilevel network meta-regression (ML-NMR), external control arms (ECA), surrogate endpoint validation, treatment switching adjustment, and baseline risk and effect modifier modeling, with a strong focus on regulatory (i.e., FDA, EMA) and health technology assessment (HTA) decision-making (i.e., NICE, EU JCA). In our process, we begin by investing time upfront to deeply understand the research question, target population, and decision context, using structured frameworks such as target trial emulation where appropriate to ensure alignment between the evidence and the estimand of interest. We then apply a systematic approach to identify and select relevant studies, and highlight between-study differences using an estimand framework to inform the feasibility of quantitative analyses, ensuring the underlying assumptions are clearly articulated. Where necessary, we explore opportunities to borrow strength across available evidence (e.g., across studies, populations, or endpoints) to improve precision; however, this is done with an emphasis on ensuring that resulting estimates remain credible and relevant to the decision problem. We carefully balance methodological sophistication with transparency, interpretability, and stakeholder acceptability, particularly in the context of regulatory and HTA expectations. Our goal is to deliver analyses that are not only methodologically rigorous, but also clearly communicated, defensible, and directly decision-relevant.
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