Babraham Hall Babraham Cambridge, CB22 3AT United KingdomAt the Babraham Institute, our discovery science is powered by eight state-of-the-art Science Facilities that operate as open-access, service-orientated cores. Collectively they give every group—internal and external—seamless access to the instruments, expertise and data workflows needed to interrogate signalling and epigenetic mechanisms from single molecules to whole organisms. Genomics – High-throughput and single-cell sequencing, methylome and chromatin-accessibility profiling, supported by end-to-end library prep and QC pipelines. Bioinformatics – Dedicated analysts who develop and run bespoke pipelines, provide statistics support and help visualise complex multi-omics data. Flow Cytometry – Eight analysers plus high-speed sorters, including the new image-enabled Attune CytPix and a spectral-flow platform added in 2024 for >30-parameter panels. Expert staff offer training, experimental design and data analysis. Imaging – Confocal, super-resolution (STED & SIM), light-sheet and intravital microscopy, with automated analysis workflows and a 24/7 booking model. Mass Spectrometry – Quantitative proteomics, phosphoproteomics, metabolomics and lipidomics on Orbitrap and Q-ToF platforms, plus specialist bio-informatics for pathway mapping. Biological Chemistry – Custom synthesis, protein–ligand interaction assays and high-throughput screening to generate probes and validate targets. Gene Targeting – CRISPR/Cas9 and ES-cell engineering services for mouse, rat and cell-line models, including conditional alleles and reporter knock-ins. Biological Support Unit (BSU) – A high-health-status animal facility with quarantine, CL-2 suites and specialist ageing, germ-free and gnotobiotic husbandry, all overseen by dedicated veterinary and welfare teams. By integrating these platforms we can capture cell-signalling dynamics, map epigenomic states and link them to functional outcomes in immune, nervous and developmental systems across the life course. The shared-cost model means researchers can pivot quickly between assays—e.g. coupling image-enabled flow sorting of aged immune cells to single-cell ATAC-seq—accelerating both fundamental insight and translational impact. Together, the core facilities form the technological backbone that turns Babraham’s bold biological questions into reproducible, high-resolution answers.

, Babraham, England CB22 3AU, GBAt the Babraham Institute, our discovery science is powered by eight state-of-the-art Science Facilities that operate as open-access, service-orientated cores. Collectively they give every group—internal and external—seamless access to the instruments, expertise and data workflows needed to interrogate signalling and epigenetic mechanisms from single molecules to whole organisms. Genomics – High-throughput and single-cell sequencing, methylome and chromatin-accessibility profiling, supported by end-to-end library prep and QC pipelines. Bioinformatics – Dedicated analysts who develop and run bespoke pipelines, provide statistics support and help visualise complex multi-omics data. Flow Cytometry – Eight analysers plus high-speed sorters, including the new image-enabled Attune CytPix and a spectral-flow platform added in 2024 for >30-parameter panels. Expert staff offer training, experimental design and data analysis. Imaging – Confocal, super-resolution (STED & SIM), light-sheet and intravital microscopy, with automated analysis workflows and a 24/7 booking model. Mass Spectrometry – Quantitative proteomics, phosphoproteomics, metabolomics and lipidomics on Orbitrap and Q-ToF platforms, plus specialist bio-informatics for pathway mapping. Biological Chemistry – Custom synthesis, protein–ligand interaction assays and high-throughput screening to generate probes and validate targets. Gene Targeting – CRISPR/Cas9 and ES-cell engineering services for mouse, rat and cell-line models, including conditional alleles and reporter knock-ins. Biological Support Unit (BSU) – A high-health-status animal facility with quarantine, CL-2 suites and specialist ageing, germ-free and gnotobiotic husbandry, all overseen by dedicated veterinary and welfare teams. By integrating these platforms we can capture cell-signalling dynamics, map epigenomic states and link them to functional outcomes in immune, nervous and developmental systems across the life course. The shared-cost model means researchers can pivot quickly between assays—e.g. coupling image-enabled flow sorting of aged immune cells to single-cell ATAC-seq—accelerating both fundamental insight and translational impact. Together, the core facilities form the technological backbone that turns Babraham’s bold biological questions into reproducible, high-resolution answers.