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1915 Aston Ave Carlsbad, CA, 92008 United StatesAccelerate biotherapeutic lead discovery with our dual wet-lab and computational antibody discovery engine. Designed for both traditional discovery teams and AI-native platforms, we perform direct single B cell isolation from rabbit blood to unlock deep repertoire diversity and native VH / VL pairing against challenging conformational epitopes. Our platform integrates AI-aided epitope engineering and OpenFold 3 3D structural modeling with automated, high-throughput wet-lab kinetic characterization (KD, ka, kd) completed in just 2 weeks. Empirical kinetic data can be leveraged directly for lead prioritization or fed back into client-proprietary AI models to power an agentic closed-loop design cycle. Top candidates transition seamlessly into full recombinant IgG expression and production in CHO cells in ISO 17025-accredited / ISO 13485 certified laboratories. Core & Additional Service Capabilities: • Single B Cell Cloning: Rapid isolation of native VH / VL paired sequences directly from rabbit blood and camelid PBMC repertoires. • Nanobody & VHH Discovery: Single-domain camelid antibody generation, screening, and engineering. • Phage Display & Hybridoma Sequencing: Repertoire screening, pan-library selection, and legacy hybridoma rescue/re-expression. • Antibody Optimization: AI-guided antibody humanization, affinity maturation, and anti-idiotype (anti-ID) antibody development. • High-Throughput Kinetic Profiling: Automated SPR and BLI analysis (Biacore, Octet, Gator) for rapid epitope binning and kinetic ranking. • CHO Scale-Up Production: Recombinant transient expression to gram-scale CHO stable line development in ISO 17025-accredited/ISO 13485 certified laboratories.
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