Viale Milano, 86, 26900 Lodi (LO) Italy Lodi, Lombardia, 26900 ItalyPI Health Sciences (PIHS) is emerging contract research organization (CRO) and contract development and manufacturing organization (CDMO) providing AI enabled integrated drug discovery chemistry, biology , pharmacology , process development and manufacturing services to biotech, mid size biotech, large pharmaceuticals and academics institutes world wide with sites in Italy, Europe and Hyderabad, Jaipur; India. a) Integrated Drug Discovery Services : Headquartered at a state-of-the-art 115,000 sq. ft. facility in Hyderabad, the discovery team integrates discovery chemistry, biology, and DMPK under one roof. i) AI & Computational Chemistry: Utilizing deep learning and structure-guided design for hit identification and lead optimization for small molecules, peptides and mAbs. ii) Medicinal Chemistry: Expertise in SAR (Structure-Activity Relationship) development and focused library synthesis. Oligonucleotides, ADCs, Carbohydrate chemistry, peptide synthesis iii) Targeted Protein Degradation (TPD): Advanced platforms for PROTACs, LYTACs, and AUTACs to tackle "undruggable" targets. iv) In Vitro Biology: cell based assays, SPR and MLR assays, biochemical assays, Comprehensive screening, molecular biology, and mechanism-of-action (MoA) validation. v) in vitro ADME , DMPK & Pharmacology vii) Preclinical toxicology b) Development Services: Location Hyderabad , Jaipur in Indian and Lodi in Italy, Europe. i) Process R&D & route scouting: Polymorph screening and salt screening ii) Scale up: Process safety, familiarization studies in Hyderabad, non GMP scale up and manufacturing in Jaipur, India and preclinical Kilo Lab supply from Lodi, Italy. iii) Manufacturing :The company specializes in transforming laboratory-scale synthesis into robust, scalable, and sustainable industrial processes. iv) High Potency API (HPAPI): Specialized infrastructure to handle highly potent molecules up to OEB 6 levels. iv) Specialized Chemistries: Capabilities in cryogenics (down to -60°C), hydrogenation, and hazardous reactions. c) Niche Services: i) Flow chemistry for safer and energy efficient routes for hazardous chemistry. Pilot and commercial scale experience available. ii) Biocatalysis for peptides, intermediates and APIs in developing greener and safer routes. In house enzyme collection available. iii) Immunogenicity services for synthetic peptides, mAbs and Biosimilars. iv) in-silico genotoxicity prediction. v) Peptides , Phosphoramidites at discovery & development scale. d) Generic API : Through the acquisition of Archimica S.p.A. (Italy), PI Health Sciences offers a strong portfolio of generic APIs and custom manufacturing for regulated markets with therapeutic Focus: Oncology, CNS (Antipsychotics), Anti-ulcers, Anti-inflammatories, Cardiology, etc. ii) Certification: Sites are regularly inspected and approved by the US-FDA, AIFA (Italy), KFDA (Korea), and other global health authorities.

PI HEALTH SCIENCES LTD, Plot No DS-10, IKP Knowledge Park, Survey No. 542/2, Koltur village Turkapally, Shamirpet Mandal, Medchal Malkajgiri District, Telangana 500101 Hyderabad, Telangana, 500101 IndiaPI Health Sciences (PIHS) is emerging contract research organization (CRO) and contract development and manufacturing organization (CDMO) providing AI enabled integrated drug discovery chemistry, biology , pharmacology , process development and manufacturing services to biotech, mid size biotech, large pharmaceuticals and academics institutes world wide with sites in Italy, Europe and Hyderabad, Jaipur; India. a) Integrated Drug Discovery Services : Headquartered at a state-of-the-art 115,000 sq. ft. facility in Hyderabad, the discovery team integrates discovery chemistry, biology, and DMPK under one roof. i) AI & Computational Chemistry: Utilizing deep learning and structure-guided design for hit identification and lead optimization for small molecules, peptides and mAbs. ii) Medicinal Chemistry: Expertise in SAR (Structure-Activity Relationship) development and focused library synthesis. Oligonucleotides, ADCs, Carbohydrate chemistry, peptide synthesis iii) Targeted Protein Degradation (TPD): Advanced platforms for PROTACs, LYTACs, and AUTACs to tackle "undruggable" targets. iv) In Vitro Biology: cell based assays, SPR and MLR assays, biochemical assays, Comprehensive screening, molecular biology, and mechanism-of-action (MoA) validation. v) in vitro ADME , DMPK & Pharmacology vii) Preclinical toxicology b) Development Services: Location Hyderabad , Jaipur in Indian and Lodi in Italy, Europe. i) Process R&D & route scouting: Polymorph screening and salt screening ii) Scale up: Process safety, familiarization studies in Hyderabad, non GMP scale up and manufacturing in Jaipur, India and preclinical Kilo Lab supply from Lodi, Italy. iii) Manufacturing :The company specializes in transforming laboratory-scale synthesis into robust, scalable, and sustainable industrial processes. iv) High Potency API (HPAPI): Specialized infrastructure to handle highly potent molecules up to OEB 6 levels. iv) Specialized Chemistries: Capabilities in cryogenics (down to -60°C), hydrogenation, and hazardous reactions. c) Niche Services: i) Flow chemistry for safer and energy efficient routes for hazardous chemistry. Pilot and commercial scale experience available. ii) Biocatalysis for peptides, intermediates and APIs in developing greener and safer routes. In house enzyme collection available. iii) Immunogenicity services for synthetic peptides, mAbs and Biosimilars. iv) in-silico genotoxicity prediction. v) Peptides , Phosphoramidites at discovery & development scale. d) Generic API : Through the acquisition of Archimica S.p.A. (Italy), PI Health Sciences offers a strong portfolio of generic APIs and custom manufacturing for regulated markets with therapeutic Focus: Oncology, CNS (Antipsychotics), Anti-ulcers, Anti-inflammatories, Cardiology, etc. ii) Certification: Sites are regularly inspected and approved by the US-FDA, AIFA (Italy), KFDA (Korea), and other global health authorities.

E-969, 969A, Biotech Park RIICO Industrial Area, Sitapura Jaipur, Rajasthan, 302022 IndiaPI Health Sciences (PIHS) is emerging contract research organization (CRO) and contract development and manufacturing organization (CDMO) providing AI enabled integrated drug discovery chemistry, biology , pharmacology , process development and manufacturing services to biotech, mid size biotech, large pharmaceuticals and academics institutes world wide with sites in Italy, Europe and Hyderabad, Jaipur; India. a) Integrated Drug Discovery Services : Headquartered at a state-of-the-art 115,000 sq. ft. facility in Hyderabad, the discovery team integrates discovery chemistry, biology, and DMPK under one roof. i) AI & Computational Chemistry: Utilizing deep learning and structure-guided design for hit identification and lead optimization for small molecules, peptides and mAbs. ii) Medicinal Chemistry: Expertise in SAR (Structure-Activity Relationship) development and focused library synthesis. Oligonucleotides, ADCs, Carbohydrate chemistry, peptide synthesis iii) Targeted Protein Degradation (TPD): Advanced platforms for PROTACs, LYTACs, and AUTACs to tackle "undruggable" targets. iv) In Vitro Biology: cell based assays, SPR and MLR assays, biochemical assays, Comprehensive screening, molecular biology, and mechanism-of-action (MoA) validation. v) in vitro ADME , DMPK & Pharmacology vii) Preclinical toxicology b) Development Services: Location Hyderabad , Jaipur in Indian and Lodi in Italy, Europe. i) Process R&D & route scouting: Polymorph screening and salt screening ii) Scale up: Process safety, familiarization studies in Hyderabad, non GMP scale up and manufacturing in Jaipur, India and preclinical Kilo Lab supply from Lodi, Italy. iii) Manufacturing :The company specializes in transforming laboratory-scale synthesis into robust, scalable, and sustainable industrial processes. iv) High Potency API (HPAPI): Specialized infrastructure to handle highly potent molecules up to OEB 6 levels. iv) Specialized Chemistries: Capabilities in cryogenics (down to -60°C), hydrogenation, and hazardous reactions. c) Niche Services: i) Flow chemistry for safer and energy efficient routes for hazardous chemistry. Pilot and commercial scale experience available. ii) Biocatalysis for peptides, intermediates and APIs in developing greener and safer routes. In house enzyme collection available. iii) Immunogenicity services for synthetic peptides, mAbs and Biosimilars. iv) in-silico genotoxicity prediction. v) Peptides , Phosphoramidites at discovery & development scale. d) Generic API : Through the acquisition of Archimica S.p.A. (Italy), PI Health Sciences offers a strong portfolio of generic APIs and custom manufacturing for regulated markets with therapeutic Focus: Oncology, CNS (Antipsychotics), Anti-ulcers, Anti-inflammatories, Cardiology, etc. ii) Certification: Sites are regularly inspected and approved by the US-FDA, AIFA (Italy), KFDA (Korea), and other global health authorities.

Unit no.4C 1st Floor, The ORB, CTS no. 1483 D, IA Project Road, Next to JW Marriott Hotel, Sahar, Village Marol, Taluka, Andheri East, Mumbai, MAHARASHTRA, 400099 IndiaPI Health Sciences (PIHS) is emerging contract research organization (CRO) and contract development and manufacturing organization (CDMO) providing AI enabled integrated drug discovery chemistry, biology , pharmacology , process development and manufacturing services to biotech, mid size biotech, large pharmaceuticals and academics institutes world wide with sites in Italy, Europe and Hyderabad, Jaipur; India. a) Integrated Drug Discovery Services : Headquartered at a state-of-the-art 115,000 sq. ft. facility in Hyderabad, the discovery team integrates discovery chemistry, biology, and DMPK under one roof. i) AI & Computational Chemistry: Utilizing deep learning and structure-guided design for hit identification and lead optimization for small molecules, peptides and mAbs. ii) Medicinal Chemistry: Expertise in SAR (Structure-Activity Relationship) development and focused library synthesis. Oligonucleotides, ADCs, Carbohydrate chemistry, peptide synthesis iii) Targeted Protein Degradation (TPD): Advanced platforms for PROTACs, LYTACs, and AUTACs to tackle "undruggable" targets. iv) In Vitro Biology: cell based assays, SPR and MLR assays, biochemical assays, Comprehensive screening, molecular biology, and mechanism-of-action (MoA) validation. v) in vitro ADME , DMPK & Pharmacology vii) Preclinical toxicology b) Development Services: Location Hyderabad , Jaipur in Indian and Lodi in Italy, Europe. i) Process R&D & route scouting: Polymorph screening and salt screening ii) Scale up: Process safety, familiarization studies in Hyderabad, non GMP scale up and manufacturing in Jaipur, India and preclinical Kilo Lab supply from Lodi, Italy. iii) Manufacturing :The company specializes in transforming laboratory-scale synthesis into robust, scalable, and sustainable industrial processes. iv) High Potency API (HPAPI): Specialized infrastructure to handle highly potent molecules up to OEB 6 levels. iv) Specialized Chemistries: Capabilities in cryogenics (down to -60°C), hydrogenation, and hazardous reactions. c) Niche Services: i) Flow chemistry for safer and energy efficient routes for hazardous chemistry. Pilot and commercial scale experience available. ii) Biocatalysis for peptides, intermediates and APIs in developing greener and safer routes. In house enzyme collection available. iii) Immunogenicity services for synthetic peptides, mAbs and Biosimilars. iv) in-silico genotoxicity prediction. v) Peptides , Phosphoramidites at discovery & development scale. d) Generic API : Through the acquisition of Archimica S.p.A. (Italy), PI Health Sciences offers a strong portfolio of generic APIs and custom manufacturing for regulated markets with therapeutic Focus: Oncology, CNS (Antipsychotics), Anti-ulcers, Anti-inflammatories, Cardiology, etc. ii) Certification: Sites are regularly inspected and approved by the US-FDA, AIFA (Italy), KFDA (Korea), and other global health authorities.