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6710 Quality Way Portage, MI, 49002 United StatesPharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services. Drug Development Services • full range of pharmacokinetic and ADME services for IND/NDA • vivarium with skilled technical staff • LC-MS/MS method development and validation • FDA Crystal City guidelines • GLP compliant sample analysis Biochemistry Services • cell-based assays • protein expression o prokaryotic (E.coli) o eukaryotic (mammalian, insect cell/baculovirus) • protein purification • ligand binding assays • isothermal denaturation • enzyme inhibitor characterization and mechanism • fluorescence polarization and other fluorescence based assays • biomarker assays • ELISA • MSD electrochemiluminescence Bioanalytical Services • rapid screening methods • method development and validation • FDA Crystal City • OECD • preclinical pharmacokinetics • PK/PD assessment • toxicokinetic investigations of absorption and clearance • bioavailability/bioequivalence • ocular PK • cassette (n-in-1) dosing and analysis • prodrug and metabolite PK Assays and Assay Development • immunosorbent assays • traditional ELISA (HRP, AP) • ECL (Meso Scale Discovery format) technologies • development of multiplex immunoassays using MSD technology • cell-based assays: signal transduction (eg cAMP) • ligand binding assays • radio-isotope • isothermal denaturation • fluorescence intensity and polarization • enzyme assays and kinetics • inhibitor mechanism and validation • MSD Certification • Human Aβ42 • Human Total Tau Ophthalmic Research Services • pharmacokinetics/ADME • pharmacology and biochemistry • specialized dosing • specialized tissue and fluid collection • precise sample processing and bioanalysis • biomarker assays • MSD electrochemiluminescence • standard ELISA Ocular Efficacy Models • VEGF induced retinal vascular leakage (wet AMD) • blue light damage (dry AMD) • STZ induced diabetic retinopathy • laser induced CNV • LPS induced Uveitis • allergic response
6710 Quality Way Portage, MI 49002 United StatesPharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services. Drug Development Services • full range of pharmacokinetic and ADME services for IND/NDA • vivarium with skilled technical staff • LC-MS/MS method development and validation • FDA Crystal City guidelines • GLP compliant sample analysis Biochemistry Services • cell-based assays • protein expression o prokaryotic (E.coli) o eukaryotic (mammalian, insect cell/baculovirus) • protein purification • ligand binding assays • isothermal denaturation • enzyme inhibitor characterization and mechanism • fluorescence polarization and other fluorescence based assays • biomarker assays • ELISA • MSD electrochemiluminescence Bioanalytical Services • rapid screening methods • method development and validation • FDA Crystal City • OECD • preclinical pharmacokinetics • PK/PD assessment • toxicokinetic investigations of absorption and clearance • bioavailability/bioequivalence • ocular PK • cassette (n-in-1) dosing and analysis • prodrug and metabolite PK Assays and Assay Development • immunosorbent assays • traditional ELISA (HRP, AP) • ECL (Meso Scale Discovery format) technologies • development of multiplex immunoassays using MSD technology • cell-based assays: signal transduction (eg cAMP) • ligand binding assays • radio-isotope • isothermal denaturation • fluorescence intensity and polarization • enzyme assays and kinetics • inhibitor mechanism and validation • MSD Certification • Human Aβ42 • Human Total Tau Ophthalmic Research Services • pharmacokinetics/ADME • pharmacology and biochemistry • specialized dosing • specialized tissue and fluid collection • precise sample processing and bioanalysis • biomarker assays • MSD electrochemiluminescence • standard ELISA Ocular Efficacy Models • VEGF induced retinal vascular leakage (wet AMD) • blue light damage (dry AMD) • STZ induced diabetic retinopathy • laser induced CNV • LPS induced Uveitis • allergic response
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