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Via Sile 6/2 Roncade, 31056 ItalyAt Officinae Bio we're developing a platform to support the future of biologically designed therapeutics. By developing breakthroughs in AI-enabled methodologies for nucleic manufacture we’re supporting pioneering research in Gene-modified Cell therapy, Gene therapy and RNA therapeutic research. How can you work with us? DNA Platform An automated platform for streamlined development of plasmids and libraries for viral vector and mRNA. CDS libraries Precise variant control and representation of codons for protein expressing sequences. Specify an exact combination of codons, a precise percentage of desired amino acids and reduce frameshift mutations for the best mutant integrity. Or introduce singular mutations in a user-defined region or truncate a sequence to characterize and optimize the desired protein features and function. Combinatorial Libraries A powerful tool for determining and optimizing biomolecule function from a parent sequence. Create a library of randomized, partially randomized or specifically designated mutants with multiple, different combinations of genetic elements. Precisely create codon or DNA part variants in combination to efficiently explore the vast design space. Complex construct synthesis Design DNA for functionality while we handle the construction. With DNA construct synthesis up to 50kbp and none of the complexity limits of traditional manufacture methods, you concentrate on design while we bring your creations to life. RNA Platform Our industry leading mRNA development and manufacturing solutions support rapid turnaround, advanced transcription capabilities and precision control over regulatory sequences design. In Vitro RNA Transcription Our foundry capabilities allow for in vitro RNA transcription from any DNA template to eliminate traditional constraints faced in research. Complex sequences, flexibility over capping and precise length polyA tail all delivered with high fidelity, purity, and yield allows you to explore a limitless range of research applications. UTR Libraries Explore and optimise regulatory sequences with in vitro verified DNA parts and targeted sequence variants of 3' and 5' untranslated regions. Why Choose Us? Complex design as standard Explore a near limitless sequence space with industry leading standards on GC content (15-85%), long stretches of repeating sequences and homopolymers (150bp), Work with collections Mix and match de novo synthesis of your target sequences with in vivo verified parts from our collections. Or synthesise, store and reuse your own frequently used parts. That way you can save time and budget on your projects. Precise Codon and Amino Acid representation Control precisely the codon and amino acid representation in your library to match requirements for your research. Our precision synthesis services lets you balance or bias representation as needed. Highly Diverse, Highly Complex Our precision DNA synthesis platform allows you to explore the entire sequence space, without compromise. Library diversity up to 10^9 and capabilities to produce highly complex libraries with variants across multiple non-contiguous sequences of interest effectively multiples your discovery potential. Precise control over Poly A tails Our unique Modular Assembly Protocols allow for sequence- and length-perfect polyA tails for DNA templates, giving you unprecedented control over mRNA in vivo stability and translation efficiency. Choose from our flexible length options of Sanger-verified 40, 80, or 120bp to tailor your project to perfection.
Via Verdi 32 Venice, Italy, VE, IT-30174 ItalyAt Officinae Bio we're developing a platform to support the future of biologically designed therapeutics. By developing breakthroughs in AI-enabled methodologies for nucleic manufacture we’re supporting pioneering research in Gene-modified Cell therapy, Gene therapy and RNA therapeutic research. How can you work with us? DNA Platform An automated platform for streamlined development of plasmids and libraries for viral vector and mRNA. CDS libraries Precise variant control and representation of codons for protein expressing sequences. Specify an exact combination of codons, a precise percentage of desired amino acids and reduce frameshift mutations for the best mutant integrity. Or introduce singular mutations in a user-defined region or truncate a sequence to characterize and optimize the desired protein features and function. Combinatorial Libraries A powerful tool for determining and optimizing biomolecule function from a parent sequence. Create a library of randomized, partially randomized or specifically designated mutants with multiple, different combinations of genetic elements. Precisely create codon or DNA part variants in combination to efficiently explore the vast design space. Complex construct synthesis Design DNA for functionality while we handle the construction. With DNA construct synthesis up to 50kbp and none of the complexity limits of traditional manufacture methods, you concentrate on design while we bring your creations to life. RNA Platform Our industry leading mRNA development and manufacturing solutions support rapid turnaround, advanced transcription capabilities and precision control over regulatory sequences design. In Vitro RNA Transcription Our foundry capabilities allow for in vitro RNA transcription from any DNA template to eliminate traditional constraints faced in research. Complex sequences, flexibility over capping and precise length polyA tail all delivered with high fidelity, purity, and yield allows you to explore a limitless range of research applications. UTR Libraries Explore and optimise regulatory sequences with in vitro verified DNA parts and targeted sequence variants of 3' and 5' untranslated regions. Why Choose Us? Complex design as standard Explore a near limitless sequence space with industry leading standards on GC content (15-85%), long stretches of repeating sequences and homopolymers (150bp), Work with collections Mix and match de novo synthesis of your target sequences with in vivo verified parts from our collections. Or synthesise, store and reuse your own frequently used parts. That way you can save time and budget on your projects. Precise Codon and Amino Acid representation Control precisely the codon and amino acid representation in your library to match requirements for your research. Our precision synthesis services lets you balance or bias representation as needed. Highly Diverse, Highly Complex Our precision DNA synthesis platform allows you to explore the entire sequence space, without compromise. Library diversity up to 10^9 and capabilities to produce highly complex libraries with variants across multiple non-contiguous sequences of interest effectively multiples your discovery potential. Precise control over Poly A tails Our unique Modular Assembly Protocols allow for sequence- and length-perfect polyA tails for DNA templates, giving you unprecedented control over mRNA in vivo stability and translation efficiency. Choose from our flexible length options of Sanger-verified 40, 80, or 120bp to tailor your project to perfection.
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