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Bristol Road, Portishead Unit 10 Portis Field Bristol, Sommerset, BS20 6PN United KingdomNexus BioQuest is a pre‑clinically focused Immunology CRO delivering advanced in vitro services that support emerging trends in the discovery and development of immune‑therapeutics. Our portfolio is designed to address the growing complexity of modern immunology programs, bridging cutting‑edge biology with predictive, translational preclinical models. Focusing on immuno-oncology, autoimmunity, hypersensitivity, neuro/inflammation we leverage the latest advances in human immunology, novel therapeutic modalities, and disease‑relevant systems to generate data that meaningfully informs decision‑making. We continuously expand and evolve our platform by integrating new technologies and assay formats, including 2D and 3D models, and the use of healthy and patient‑derived primary material, ensuring our offerings keep pace with the rapidly changing needs of biotechnology and pharmaceutical partners. In doing so, we enable robust de‑risking strategies and accelerate progress toward clinical development. At our core, Nexus BioQuest is built on three pillars: Expertise Deep immunology knowledge and hands‑on experience across innate, adaptive, and tissue‑based biology allow us to tackle complex scientific questions and design assays that are both mechanistically insightful and translationally relevant. Tempo An agile, rapidly expandable operational model minimises bureaucracy and administrative burden, enabling fast execution and responsive collaboration without compromising scientific quality. Collaboration We work as an extension of our partners’ teams, fostering open, transparent, and trust‑based relationships that move beyond a purely transactional CRO model to maximise scientific impact. Scientific capabilities and solutions Our science underpins a comprehensive suite of customisable assay solutions, selected and tailored based on the specific research question. These assays are designed to model relevant aspects of the human immune response and together form an integrated preclinical and IND‑enabling package, including: Relevant target expression profiling across key immune cell subsets and tissues Mode‑of‑action characterisation to confirm biological engagement and pathway modulation Efficacy assessments in mechanistic and disease‑relevant human systems Biomarker identification, supporting translational alignment and clinical strategy Predictive immunotoxicity, helping to anticipate safety risks early in development Key platforms: NovoCyte Penteon Flow Cytometer, CELLCYTE X, high-throughput live cell imaging-96 well, Image Xpress Confocal high content imager-384 well, Opera Phenix- 3D, organoid modelling, Olink proteomics, Meso Scale Discovery (MSD), Spectramax i3a, ELISpot, qPCR, Western Blot. By combining these elements, Nexus BioQuest supports partners across multiple stages of the preclinical drug development pathway, from early discovery through IND‑supporting studies. All of our work is grounded in a deep understanding of immune biology, enabling us to deliver relevant, flexible, and state‑of‑the‑art assays that align closely with therapeutic intent. Our goal is to empower our partners with high‑quality, decision‑ready data that advances immune‑therapeutic programs with confidence toward the clinic.
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