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Department of Physiology, Faculty of Biomedical and Psychological Sciences, Monash Biomedicine Discovery Institute, Monash University Building 13F, Clayton Campus 26 Innovation Walk, Clayton Melbourne, VIC, 3800 AustraliaNeuroSolutions Ltd. was established in the UK in 2001 to provide clients with highly specialised contract electrophysiological research. Our related companies are based in Montreal, Canada (Cerebrasol Canada Ltd) and Melbourne, Australia (Pacific Discovery Services Ltd) with further laboratories in Bogor, Indonesia. The companies provide a flexible, highly skilled service with fast turnaround that meets the needs of a wide range of biopharmaceutical companies. Our large portfolio of clients, many of them repeat customers, ranging from small start-ups to multinational pharmaceutical companies provides validation of our quality, reliability, speed and discretion. We have recently added the ability to work with both Non-Human Primate (NHP) and Human Tissue. How we do this; In vivo electrophysiology Almost all brain regions, spinal cord, nerve fibres single fibre level, naïve and model animals In vitro electrophysiology Almost all brain regions, spinal cord, naïve and model animals, single/dual recordings in rodent, NHP and Human Slice Tissue and DRG, iPSC, Cell Lines Molecular biology services Single cell rt-PCR, real time qPCR, immunohistochemistry Behavioural modelling of disease Pain models (Chung, CCI etc.), anxiety, obesity, Alzheimer’s, Parkinson's, Huntington's disease, MS Range of Projects; Simple fee for service: single compound contract Multiple FTE contracts: mechanism of action of a series of compounds Speciality in providing ‘proof of concept’ studies for novel chemical entities Areas; Pain; Acute, Surgical, Neuropathic, Inflammatory, Migraine, Arthritis, Diabetic Neuropathy, Chemotherapy neuropathy, Neurodegeneration; Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Huntington's Disease Psychiatry; Depression, Anxiety, Schizophrenia, Psycosis Other; Obesity, Epilepsy, Diabetes, Channelopathies, Safety Pharmacology Example Range of Models for Pain; Chronic constriction injury Spinal nerve ligation Diabetes-induced Chemotherapy-induced Fracture pain model Carrageenan Complete Freund’s adjuvant Formalin MIA UVB Surgical pain Pain Behavioural Readouts; Von Frey hair Hargreave’s Randall-Selitto Weight-bearing Paw licking, shaking, lifting Plethysmography RotaRod test Pain Electrohphysiological Assays; In vivo: Single fibre recording, spontaneous and evoked, single neurone recording from the spinal cord and brain, all naïve and modelled animals In vitro: Compound action potential recording from isolated nerves, naïve and modelled, slice patch-clamp recordings, dissociated DRG patch-clamp recordings from naïve and modelled animals Neurodegeneration Behavioural Tests; Open field: e.g. object recognition test (ORT), Y-maze, Barnes maze Operant chambers: e.g. Alternating Lever Cyclic Ratio (ALCR), delayed match-to-position (DMTP/DNMTP) Beta-amyloid induced deficits (ADDL/APP/oligomers/aggregated) α-synuclein-induced deficits Commercially available transgenic rodent models Neurodegeneration Electrophysiological Assays; In vivo: single cells – extra and intracellular recording; iontophoretic, central and parenteral drug administration Local field potentials – spontaneous and evoked, including LTP/LTD Peripheral nerves – compound and single fibre Telemetric and multi-electrode recording In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines Psychiatry Behavioural Tests; Barnes maze Conflict anxiety model (high level illumination & odour) Psychiatry Electrophysiological Assays; In vivo: single unit recordings from hippocampus/ striatum/ substantia nigra/ dorsal raphe/ prefrontal cortex / brainstem Local field potential/population spike recording from hippocampus; CA1/DG/CA3, LTP, MEA In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel Pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines1 Other Behavioural Tests; DIO Transgenic Mice Electrophysiological Assays; In vivo: single unit recordings from most characterised brain regions Local field potential/population spike recording from hippocampus/cortex In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices Ion channel pharmacology: state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines
Warwick Medical School University of Warwick, Gibbet Hill Road Coventry, West Midlands, CV4 7AL United KingdomNeuroSolutions Ltd. was established in the UK in 2001 to provide clients with highly specialised contract electrophysiological research. Our related companies are based in Montreal, Canada (Cerebrasol Canada Ltd) and Melbourne, Australia (Pacific Discovery Services Ltd) with further laboratories in Bogor, Indonesia. The companies provide a flexible, highly skilled service with fast turnaround that meets the needs of a wide range of biopharmaceutical companies. Our large portfolio of clients, many of them repeat customers, ranging from small start-ups to multinational pharmaceutical companies provides validation of our quality, reliability, speed and discretion. We have recently added the ability to work with both Non-Human Primate (NHP) and Human Tissue. How we do this; In vivo electrophysiology Almost all brain regions, spinal cord, nerve fibres single fibre level, naïve and model animals In vitro electrophysiology Almost all brain regions, spinal cord, naïve and model animals, single/dual recordings in rodent, NHP and Human Slice Tissue and DRG, iPSC, Cell Lines Molecular biology services Single cell rt-PCR, real time qPCR, immunohistochemistry Behavioural modelling of disease Pain models (Chung, CCI etc.), anxiety, obesity, Alzheimer’s, Parkinson's, Huntington's disease, MS Range of Projects; Simple fee for service: single compound contract Multiple FTE contracts: mechanism of action of a series of compounds Speciality in providing ‘proof of concept’ studies for novel chemical entities Areas; Pain; Acute, Surgical, Neuropathic, Inflammatory, Migraine, Arthritis, Diabetic Neuropathy, Chemotherapy neuropathy, Neurodegeneration; Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Huntington's Disease Psychiatry; Depression, Anxiety, Schizophrenia, Psycosis Other; Obesity, Epilepsy, Diabetes, Channelopathies, Safety Pharmacology Example Range of Models for Pain; Chronic constriction injury Spinal nerve ligation Diabetes-induced Chemotherapy-induced Fracture pain model Carrageenan Complete Freund’s adjuvant Formalin MIA UVB Surgical pain Pain Behavioural Readouts; Von Frey hair Hargreave’s Randall-Selitto Weight-bearing Paw licking, shaking, lifting Plethysmography RotaRod test Pain Electrohphysiological Assays; In vivo: Single fibre recording, spontaneous and evoked, single neurone recording from the spinal cord and brain, all naïve and modelled animals In vitro: Compound action potential recording from isolated nerves, naïve and modelled, slice patch-clamp recordings, dissociated DRG patch-clamp recordings from naïve and modelled animals Neurodegeneration Behavioural Tests; Open field: e.g. object recognition test (ORT), Y-maze, Barnes maze Operant chambers: e.g. Alternating Lever Cyclic Ratio (ALCR), delayed match-to-position (DMTP/DNMTP) Beta-amyloid induced deficits (ADDL/APP/oligomers/aggregated) α-synuclein-induced deficits Commercially available transgenic rodent models Neurodegeneration Electrophysiological Assays; In vivo: single cells – extra and intracellular recording; iontophoretic, central and parenteral drug administration Local field potentials – spontaneous and evoked, including LTP/LTD Peripheral nerves – compound and single fibre Telemetric and multi-electrode recording In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines Psychiatry Behavioural Tests; Barnes maze Conflict anxiety model (high level illumination & odour) Psychiatry Electrophysiological Assays; In vivo: single unit recordings from hippocampus/ striatum/ substantia nigra/ dorsal raphe/ prefrontal cortex / brainstem Local field potential/population spike recording from hippocampus; CA1/DG/CA3, LTP, MEA In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel Pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines1 Other Behavioural Tests; DIO Transgenic Mice Electrophysiological Assays; In vivo: single unit recordings from most characterised brain regions Local field potential/population spike recording from hippocampus/cortex In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices Ion channel pharmacology: state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines
Montreal Montreal , Quebec, H4S 1Z9 CanadaNeuroSolutions Ltd. was established in the UK in 2001 to provide clients with highly specialised contract electrophysiological research. Our related companies are based in Montreal, Canada (Cerebrasol Canada Ltd) and Melbourne, Australia (Pacific Discovery Services Ltd) with further laboratories in Bogor, Indonesia. The companies provide a flexible, highly skilled service with fast turnaround that meets the needs of a wide range of biopharmaceutical companies. Our large portfolio of clients, many of them repeat customers, ranging from small start-ups to multinational pharmaceutical companies provides validation of our quality, reliability, speed and discretion. We have recently added the ability to work with both Non-Human Primate (NHP) and Human Tissue. How we do this; In vivo electrophysiology Almost all brain regions, spinal cord, nerve fibres single fibre level, naïve and model animals In vitro electrophysiology Almost all brain regions, spinal cord, naïve and model animals, single/dual recordings in rodent, NHP and Human Slice Tissue and DRG, iPSC, Cell Lines Molecular biology services Single cell rt-PCR, real time qPCR, immunohistochemistry Behavioural modelling of disease Pain models (Chung, CCI etc.), anxiety, obesity, Alzheimer’s, Parkinson's, Huntington's disease, MS Range of Projects; Simple fee for service: single compound contract Multiple FTE contracts: mechanism of action of a series of compounds Speciality in providing ‘proof of concept’ studies for novel chemical entities Areas; Pain; Acute, Surgical, Neuropathic, Inflammatory, Migraine, Arthritis, Diabetic Neuropathy, Chemotherapy neuropathy, Neurodegeneration; Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Huntington's Disease Psychiatry; Depression, Anxiety, Schizophrenia, Psycosis Other; Obesity, Epilepsy, Diabetes, Channelopathies, Safety Pharmacology Example Range of Models for Pain; Chronic constriction injury Spinal nerve ligation Diabetes-induced Chemotherapy-induced Fracture pain model Carrageenan Complete Freund’s adjuvant Formalin MIA UVB Surgical pain Pain Behavioural Readouts; Von Frey hair Hargreave’s Randall-Selitto Weight-bearing Paw licking, shaking, lifting Plethysmography RotaRod test Pain Electrohphysiological Assays; In vivo: Single fibre recording, spontaneous and evoked, single neurone recording from the spinal cord and brain, all naïve and modelled animals In vitro: Compound action potential recording from isolated nerves, naïve and modelled, slice patch-clamp recordings, dissociated DRG patch-clamp recordings from naïve and modelled animals Neurodegeneration Behavioural Tests; Open field: e.g. object recognition test (ORT), Y-maze, Barnes maze Operant chambers: e.g. Alternating Lever Cyclic Ratio (ALCR), delayed match-to-position (DMTP/DNMTP) Beta-amyloid induced deficits (ADDL/APP/oligomers/aggregated) α-synuclein-induced deficits Commercially available transgenic rodent models Neurodegeneration Electrophysiological Assays; In vivo: single cells – extra and intracellular recording; iontophoretic, central and parenteral drug administration Local field potentials – spontaneous and evoked, including LTP/LTD Peripheral nerves – compound and single fibre Telemetric and multi-electrode recording In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines Psychiatry Behavioural Tests; Barnes maze Conflict anxiety model (high level illumination & odour) Psychiatry Electrophysiological Assays; In vivo: single unit recordings from hippocampus/ striatum/ substantia nigra/ dorsal raphe/ prefrontal cortex / brainstem Local field potential/population spike recording from hippocampus; CA1/DG/CA3, LTP, MEA In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel Pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines1 Other Behavioural Tests; DIO Transgenic Mice Electrophysiological Assays; In vivo: single unit recordings from most characterised brain regions Local field potential/population spike recording from hippocampus/cortex In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices Ion channel pharmacology: state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines
7171 Frederick-Banting Montreal , Quebec, H4S 1Z9 CanadaNeuroSolutions Ltd. was established in the UK in 2001 to provide clients with highly specialised contract electrophysiological research. Our related companies are based in Montreal, Canada (Cerebrasol Canada Ltd) and Melbourne, Australia (Pacific Discovery Services Ltd) with further laboratories in Bogor, Indonesia. The companies provide a flexible, highly skilled service with fast turnaround that meets the needs of a wide range of biopharmaceutical companies. Our large portfolio of clients, many of them repeat customers, ranging from small start-ups to multinational pharmaceutical companies provides validation of our quality, reliability, speed and discretion. We have recently added the ability to work with both Non-Human Primate (NHP) and Human Tissue. How we do this; In vivo electrophysiology Almost all brain regions, spinal cord, nerve fibres single fibre level, naïve and model animals In vitro electrophysiology Almost all brain regions, spinal cord, naïve and model animals, single/dual recordings in rodent, NHP and Human Slice Tissue and DRG, iPSC, Cell Lines Molecular biology services Single cell rt-PCR, real time qPCR, immunohistochemistry Behavioural modelling of disease Pain models (Chung, CCI etc.), anxiety, obesity, Alzheimer’s, Parkinson's, Huntington's disease, MS Range of Projects; Simple fee for service: single compound contract Multiple FTE contracts: mechanism of action of a series of compounds Speciality in providing ‘proof of concept’ studies for novel chemical entities Areas; Pain; Acute, Surgical, Neuropathic, Inflammatory, Migraine, Arthritis, Diabetic Neuropathy, Chemotherapy neuropathy, Neurodegeneration; Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Huntington's Disease Psychiatry; Depression, Anxiety, Schizophrenia, Psycosis Other; Obesity, Epilepsy, Diabetes, Channelopathies, Safety Pharmacology Example Range of Models for Pain; Chronic constriction injury Spinal nerve ligation Diabetes-induced Chemotherapy-induced Fracture pain model Carrageenan Complete Freund’s adjuvant Formalin MIA UVB Surgical pain Pain Behavioural Readouts; Von Frey hair Hargreave’s Randall-Selitto Weight-bearing Paw licking, shaking, lifting Plethysmography RotaRod test Pain Electrohphysiological Assays; In vivo: Single fibre recording, spontaneous and evoked, single neurone recording from the spinal cord and brain, all naïve and modelled animals In vitro: Compound action potential recording from isolated nerves, naïve and modelled, slice patch-clamp recordings, dissociated DRG patch-clamp recordings from naïve and modelled animals Neurodegeneration Behavioural Tests; Open field: e.g. object recognition test (ORT), Y-maze, Barnes maze Operant chambers: e.g. Alternating Lever Cyclic Ratio (ALCR), delayed match-to-position (DMTP/DNMTP) Beta-amyloid induced deficits (ADDL/APP/oligomers/aggregated) α-synuclein-induced deficits Commercially available transgenic rodent models Neurodegeneration Electrophysiological Assays; In vivo: single cells – extra and intracellular recording; iontophoretic, central and parenteral drug administration Local field potentials – spontaneous and evoked, including LTP/LTD Peripheral nerves – compound and single fibre Telemetric and multi-electrode recording In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines Psychiatry Behavioural Tests; Barnes maze Conflict anxiety model (high level illumination & odour) Psychiatry Electrophysiological Assays; In vivo: single unit recordings from hippocampus/ striatum/ substantia nigra/ dorsal raphe/ prefrontal cortex / brainstem Local field potential/population spike recording from hippocampus; CA1/DG/CA3, LTP, MEA In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices, including LTP/LTD and multi-electrode recording (MEA) Ion channel Pharmacology – state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines1 Other Behavioural Tests; DIO Transgenic Mice Electrophysiological Assays; In vivo: single unit recordings from most characterised brain regions Local field potential/population spike recording from hippocampus/cortex In vitro: whole-cell patch-clamp recordings from brain slices (current/voltage/blind/visualised) Local field potentials – spontaneous and evoked extracellular recordings from brain slices Ion channel pharmacology: state-dependency, kinetics, and site of action using cultured and primary dissociated neurones, cell lines
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