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628 NJ-10 Suite 10 WHIPPANY, New Jersey, 07981 United StatesPicoImmune, part of Axela Biosciences, Inc. offers ultra-sensitive, highly multiplex and reliable bioassay services for real-time monitoring of protein and gene changes in minute samples from cells, tissues, animals, and patients, thereby accelerating the discovery and development of novel therapeutics of a variety of modalities. Our team possesses extensive expertise in drug discovery and unparalleled proficiency in bioanalytical, cytometric, spatial-omic, genomic, and proteomic techniques. We harness the power of ultra-sensitive femto-scale and multiplex immunoassays as well as microarray technologies, to assess drug efficacy and elucidate the underlying mechanisms of drugs and diseases. With training from prestigious institutions such as MIT, Harvard, NIH, MSKCC, UIC, Rutgers, NYU, and Duke, and experience at leading biopharma companies including Novartis, Sanofi, Merck, BMS/Celgene, Boehringer Ingelheim and Regeneron, our scientists offer deep biopharma industry knowledge and technical proficiency. We have established a state-of-the-art infrastructure equipped with cutting-edge technologies and advanced instruments. Our suite of sophisticated platforms enables highly sensitive bioanalysis and drug screening using minimal sample sizes, thereby allowing us to meet diverse assay performance requirements. Our dedicated scientists possess extensive hands-on experience and training in utilizing these technologies and instruments, diligently adhering to well-validated protocols for swift and accurate processing and analysis of samples. Major Instruments/Platforms: • Flow Cytometry (CytoFlex S with 4 lasers, 13 colors), 2X • FlexMAP3D (beads-based protein and gene array, 96- or 384-well format) • Luminex 200 (beads-based protein and gene array, 96- well format) • MSD MESO QuickPlex, 1X • NanoString nCounter Pro (genomic profiling), 2X • NanoString GeoMx DSP (digital spatial profiler, spatial transcriptomics and proteomics), 2 X • SIMOA (Ultrasensitive SIngle MOlecule Array) • Simple Western (Gel-free Capillary-based Automatic Western Blot), 2 X • Proteomic Microarray (FPPA/RPPA) • Tecan Multimode Microplate Reader, 4 X • ABI QuantStudio Real-Time PCR, 2X • ECIS (Electric Cell-substrate Impedance Sensing) • LiCor Odyssey Near-Infrared Imaging System • ELISpot Reader • IncuCyte Live Cell Analysis System • EVOS FL Auto Cell Imaging System • Molecular Devices GenePix 4200AL Microarray Scanner • Integra ASSIST PLUS automated multichannel pipetting Robots, 2X • Miltenyi Biotec autoMACS® Pro Separator • AirClean 600 PCR Workstation, 3X Selected Publications: • Culiat C, Soni D, Malkes W, Wienhold M, Zhang LH, et al. NELL1 variant protein (NV1) modulates hyper-inflammation, Th-1 mediated immune response, and the HIF-1α hypoxia pathway to promote healing in viral-induced lung injury. Biochem Biophys Res Commun. 2025 Jan; 744:151198. doi: 10.1016/j.bbrc.2024.151198. • Schafer, P.H., Truzzib, F. Parton, A., Wu, L., Kosek, J., Zhang, L.H., et al., "Phosphodiesterase 4 in inflammatory diseases: effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex", Cellular Signalling. Vol. 28, pp 53-63, 2016. • Yang HY, Barbi J, Wu CY, Zheng Y, Park BV, Zhang J, Bandara S, Pardoll DM, Li H, Pan F. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators. Immunity. Volume 45, pp83-93, 2016 • Henry EK, Sy CB, Inclan-Rico JM, Espinosa V, Ghanny SS, Dwyer DF, Soteropoulos P, Rivera A, Siracusa MC. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. Vol.213,1663-73, 2016. • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Control of Th17/Treg Balance by Hypoxia-inducible Factor 1. Cell.146, 772-84, 2011
622 Route-10 West Unit 18 Whippany, NJ, 07981 United StatesPicoImmune, part of Axela Biosciences, Inc. offers ultra-sensitive, highly multiplex and reliable bioassay services for real-time monitoring of protein and gene changes in minute samples from cells, tissues, animals, and patients, thereby accelerating the discovery and development of novel therapeutics of a variety of modalities. Our team possesses extensive expertise in drug discovery and unparalleled proficiency in bioanalytical, cytometric, spatial-omic, genomic, and proteomic techniques. We harness the power of ultra-sensitive femto-scale and multiplex immunoassays as well as microarray technologies, to assess drug efficacy and elucidate the underlying mechanisms of drugs and diseases. With training from prestigious institutions such as MIT, Harvard, NIH, MSKCC, UIC, Rutgers, NYU, and Duke, and experience at leading biopharma companies including Novartis, Sanofi, Merck, BMS/Celgene, Boehringer Ingelheim and Regeneron, our scientists offer deep biopharma industry knowledge and technical proficiency. We have established a state-of-the-art infrastructure equipped with cutting-edge technologies and advanced instruments. Our suite of sophisticated platforms enables highly sensitive bioanalysis and drug screening using minimal sample sizes, thereby allowing us to meet diverse assay performance requirements. Our dedicated scientists possess extensive hands-on experience and training in utilizing these technologies and instruments, diligently adhering to well-validated protocols for swift and accurate processing and analysis of samples. Major Instruments/Platforms: • Flow Cytometry (CytoFlex S with 4 lasers, 13 colors), 2X • FlexMAP3D (beads-based protein and gene array, 96- or 384-well format) • Luminex 200 (beads-based protein and gene array, 96- well format) • MSD MESO QuickPlex, 1X • NanoString nCounter Pro (genomic profiling), 2X • NanoString GeoMx DSP (digital spatial profiler, spatial transcriptomics and proteomics), 2 X • SIMOA (Ultrasensitive SIngle MOlecule Array) • Simple Western (Gel-free Capillary-based Automatic Western Blot), 2 X • Proteomic Microarray (FPPA/RPPA) • Tecan Multimode Microplate Reader, 4 X • ABI QuantStudio Real-Time PCR, 2X • ECIS (Electric Cell-substrate Impedance Sensing) • LiCor Odyssey Near-Infrared Imaging System • ELISpot Reader • IncuCyte Live Cell Analysis System • EVOS FL Auto Cell Imaging System • Molecular Devices GenePix 4200AL Microarray Scanner • Integra ASSIST PLUS automated multichannel pipetting Robots, 2X • Miltenyi Biotec autoMACS® Pro Separator • AirClean 600 PCR Workstation, 3X Selected Publications: • Culiat C, Soni D, Malkes W, Wienhold M, Zhang LH, et al. NELL1 variant protein (NV1) modulates hyper-inflammation, Th-1 mediated immune response, and the HIF-1α hypoxia pathway to promote healing in viral-induced lung injury. Biochem Biophys Res Commun. 2025 Jan; 744:151198. doi: 10.1016/j.bbrc.2024.151198. • Schafer, P.H., Truzzib, F. Parton, A., Wu, L., Kosek, J., Zhang, L.H., et al., "Phosphodiesterase 4 in inflammatory diseases: effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex", Cellular Signalling. Vol. 28, pp 53-63, 2016. • Yang HY, Barbi J, Wu CY, Zheng Y, Park BV, Zhang J, Bandara S, Pardoll DM, Li H, Pan F. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators. Immunity. Volume 45, pp83-93, 2016 • Henry EK, Sy CB, Inclan-Rico JM, Espinosa V, Ghanny SS, Dwyer DF, Soteropoulos P, Rivera A, Siracusa MC. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. Vol.213,1663-73, 2016. • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Control of Th17/Treg Balance by Hypoxia-inducible Factor 1. Cell.146, 772-84, 2011
628 NJ-10 Suite 10 WHIPPANY, NJ, 07981 United StatesPicoImmune, part of Axela Biosciences, Inc. offers ultra-sensitive, highly multiplex and reliable bioassay services for real-time monitoring of protein and gene changes in minute samples from cells, tissues, animals, and patients, thereby accelerating the discovery and development of novel therapeutics of a variety of modalities. Our team possesses extensive expertise in drug discovery and unparalleled proficiency in bioanalytical, cytometric, spatial-omic, genomic, and proteomic techniques. We harness the power of ultra-sensitive femto-scale and multiplex immunoassays as well as microarray technologies, to assess drug efficacy and elucidate the underlying mechanisms of drugs and diseases. With training from prestigious institutions such as MIT, Harvard, NIH, MSKCC, UIC, Rutgers, NYU, and Duke, and experience at leading biopharma companies including Novartis, Sanofi, Merck, BMS/Celgene, Boehringer Ingelheim and Regeneron, our scientists offer deep biopharma industry knowledge and technical proficiency. We have established a state-of-the-art infrastructure equipped with cutting-edge technologies and advanced instruments. Our suite of sophisticated platforms enables highly sensitive bioanalysis and drug screening using minimal sample sizes, thereby allowing us to meet diverse assay performance requirements. Our dedicated scientists possess extensive hands-on experience and training in utilizing these technologies and instruments, diligently adhering to well-validated protocols for swift and accurate processing and analysis of samples. Major Instruments/Platforms: • Flow Cytometry (CytoFlex S with 4 lasers, 13 colors), 2X • FlexMAP3D (beads-based protein and gene array, 96- or 384-well format) • Luminex 200 (beads-based protein and gene array, 96- well format) • MSD MESO QuickPlex, 1X • NanoString nCounter Pro (genomic profiling), 2X • NanoString GeoMx DSP (digital spatial profiler, spatial transcriptomics and proteomics), 2 X • SIMOA (Ultrasensitive SIngle MOlecule Array) • Simple Western (Gel-free Capillary-based Automatic Western Blot), 2 X • Proteomic Microarray (FPPA/RPPA) • Tecan Multimode Microplate Reader, 4 X • ABI QuantStudio Real-Time PCR, 2X • ECIS (Electric Cell-substrate Impedance Sensing) • LiCor Odyssey Near-Infrared Imaging System • ELISpot Reader • IncuCyte Live Cell Analysis System • EVOS FL Auto Cell Imaging System • Molecular Devices GenePix 4200AL Microarray Scanner • Integra ASSIST PLUS automated multichannel pipetting Robots, 2X • Miltenyi Biotec autoMACS® Pro Separator • AirClean 600 PCR Workstation, 3X Selected Publications: • Culiat C, Soni D, Malkes W, Wienhold M, Zhang LH, et al. NELL1 variant protein (NV1) modulates hyper-inflammation, Th-1 mediated immune response, and the HIF-1α hypoxia pathway to promote healing in viral-induced lung injury. Biochem Biophys Res Commun. 2025 Jan; 744:151198. doi: 10.1016/j.bbrc.2024.151198. • Schafer, P.H., Truzzib, F. Parton, A., Wu, L., Kosek, J., Zhang, L.H., et al., "Phosphodiesterase 4 in inflammatory diseases: effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex", Cellular Signalling. Vol. 28, pp 53-63, 2016. • Yang HY, Barbi J, Wu CY, Zheng Y, Park BV, Zhang J, Bandara S, Pardoll DM, Li H, Pan F. The MicroRNA miR-17 modulates regulatory T cell activity by targeting Foxp3 Co-regulators. Immunity. Volume 45, pp83-93, 2016 • Henry EK, Sy CB, Inclan-Rico JM, Espinosa V, Ghanny SS, Dwyer DF, Soteropoulos P, Rivera A, Siracusa MC. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. Vol.213,1663-73, 2016. • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Control of Th17/Treg Balance by Hypoxia-inducible Factor 1. Cell.146, 772-84, 2011
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