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300 N Beacon Street Watertown, MA, 02472 5750 United StatesOverview Artis BioSolutions is an advanced therapy CDMO uniquely combining proprietary synthetic DNA (oDNA) manufacturing with integrated process development, analytical development, GMP manufacturing, fill & finish, quality control testing, and regulatory support—all within a single organization. As the first company to unite enzymatically produced synthetic DNA with downstream clinical manufacturing, Artis helps developers accelerate genetic medicines while reducing technical transfer risk and supply chain complexity. Our integrated platform supports programs from research through clinical manufacturing across a broad range of advanced therapy modalities, including: > Synthetic DNA (oDNA) > Cell therapies (CAR-T, CAR-NK, iPSC, MSC, HSC) > AAV gene therapies > Lentiviral vectors (LVV) > mRNA therapeutics > Lipid nanoparticles (LNP) > Extracellular vesicles (EVs) > Novel non-viral delivery systems > Aseptic fill & finish With operations in both the United States and Europe, Artis enables sponsors to move from DNA starting material to GMP clinical manufacturing through a single quality system and one experienced development team. Why Artis BioSolutions? Integrated from DNA to GMP: Artis is one of the only organizations capable of taking programs from synthetic DNA through process development, analytical development, GMP manufacturing, fill & finish, and release testing under one organization—reducing vendor transitions and preserving technical continuity. Proprietary Synthetic DNA (oDNA): Our enzymatic synthetic DNA platform produces linear DNA without bacterial fermentation, eliminating bacterial backbone sequences, antibiotic resistance genes, and endotoxin while delivering highly pure starting material suitable for multiple advanced therapy applications. Accelerated Timelines: Traditional plasmid production can require 3–5 months. Artis can provide synthetic oDNA in as little as 2–4 weeks, helping remove one of the largest bottlenecks in advanced therapy development. Better Starting Material Synthetic oDNA offers several advantages over conventional plasmid DNA: > No bacterial backbone > No antibiotic resistance genes > No bacterial fermentation > Reduced contamination risk > Simplified supply chain > Faster design iterations > Ideal for mRNA, AAV, gene editing, and next-generation genetic medicines > Broad Advanced Therapy Expertise Our multidisciplinary teams support development and GMP manufacturing for: > Viral vectors (AAV & LVV) > Cell therapies > mRNA > LNP formulation > Extracellular vesicles > Novel genetic medicine platforms One Quality System: Keeping development and manufacturing within one organization minimizes technology transfer, maintains process knowledge, and streamlines regulatory readiness throughout the product lifecycle. Flexible Engagement: Whether you need synthetic DNA only, process development, analytical support, or a fully integrated CDMO partner through GMP manufacturing, Artis can engage at any stage of development.
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