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One UCity 25 N. 38th Street Suite 800 Philadelphia, PA, 19104 United StatesIntegral Molecular (www.integralmolecular.com) provides specialized membrane protein reagents and antibody characterization services to enable therapeutic discovery against membrane proteins, an important group of drug targets found on the surfaces of cells and viruses. With nearly 20 years of experience, Integral Molecular is the leading provider of membrane protein solutions and has developed technologies that have enabled hundreds of companies worldwide working in research, drug discovery, and vaccine development. Our Membrane Protein Solutions include: • Membrane Proteome Array: The industry-leading specificity testing platform for targeted biotherapeutics, including antibodies, CAR-T cells, ADCs, and others. This cell-based protein array can quickly and affordably identify any off-targets your molecule may interact with across ~6,000 human membrane proteins and ~1,200 secreted proteins. It’s the only platform to screen exclusively on biologically relevant proteins in whole, unfixed cells. The MPA provides essential specificity data at the lead selection stage, and the MPA+IND service includes the necessary rigor and support for regulatory submissions. • Lipoparticles: Our virus-like particles (VLPs) present native-conformation membrane proteins at 10-100x the concentration cells can produce—for better immunization, screening, and characterization. As the inventors of the VLP technology, we produce the highest quality products, and we still specialize in difficult proteins, including GPCRs, transporters, and heterocomplexes. Offerings include custom projects and pre-validated ReadyReceptor Lipoparticles for rapid delivery. • Paratope-PLUS™ CDR-Scanning Service: This comprehensive service tests every possible individual amino acid substitution at each residue within your antibody’s complementarity-determining regions (CDRs). The resulting data set can provide the basis for antibody engineering, including improved binding and species cross-reactivity. As described in Nature Biotechnology, it can also help you secure robust protection for your antibody IP. • Shotgun Mutagenesis Epitope Mapping: Our Ala-scan epitope mapping service measures the precise binding of an antibody to the target within intact human cells. It is the only high-throughput technology that can reliably map conformational epitopes at single amino acid resolution—without the need for purified proteins. We specialize in challenging membrane proteins (GPCRs, transporter, multi-subunit) and state-dependent epitopes. • Virology: Our products and services support antibody and vaccine developers working with a broad range of viruses, including influenza, coronaviruses, dengue, Zika, Nipah, Lassa, bunyaviruses, and much more. We offer the largest selection of non-replicating viral particles for testing virus neutralization by antibodies or sera in a BSL-2 environment. Our full suite of non-replicative offerings includes Reporter Virus Particles, Influenza TiterSafe™ Particles for hemagglutination inhibition (HAI) assays, and custom strains to address your project. We also offer custom virology assay services to fit your unique research needs.
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