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405 Waltham Street Lexington, MA02421 USADespite tremendous progress in basic science, there have been no new breakthroughs in the treatment of many CNS diseases. CNS quantitative systems pharmacology is based on the realization that human pathology is driven by a network imbalance rather than deficits at a single target or gene. Computer-based modeling of biophysically realistic neuronal network circuits calibrated with human imaging and clinical data is a translational tool to assess the outcome of therapeutic interventions in complex brain circuits. The company provides insights into the systemic behavior at each R&D stage in high impact decision processes. We provide model based decision support and knowledge support from target validation to personalized medicine for Schizophrenia (PANSS Total, PANSS Negative, Cognitive Impairment) Antipsychotic-induced side effects (Extra-pyramidal symptoms, Akathisia, Prolactin increase) Alzheimer's disease (Cognition, Neuropsychiatric symptoms and Beta-amyloid dynamics) Parkinson's disease (Rigidity-bradykinesia, Tremor, L-DOPA induced dyskinesia) Our modeling addresses the following key questions Target validation Clinical candidate selection Support rationally designed multipharmacology drug discovery projects Rational support for combination therapy Clinical biomarker selection for functional target engagement Dosing guidance Clinical study design especially with comedications and genotypes Competitive analysis Clinical responder analysis
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The Contract Research Map is owned and maintained by Scientist.com. It was created to help researchers in the life sciences identify and connect with contract research organizations (CROs) based on geography. Updated nightly, this map features all of the available CROs within our network, so you can order services with a few clicks. Click on a specific country, scroll on the map itself or type into the search bar at the top—there are many ways to find the location and suppliers that you’re looking for. From Argentina to New Zealand, use this map to connect with a CRO near you.
We believe that every researcher across the world should be able to connect with the thousands of global CROs that exist and have the opportunity to work together. Like many industries,the life science supply chain has been disrupted over the last year. But there are many other circumstances such as international customs regulations or sensitive shipping times that create limitations around which countries are feasible to partner with. Sometimes, finding a CRO based in a country that best suits your research needs is imperative. We hope this contract research map allows you to find the right partner in the right place at the right time.
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Interested in connecting with one or more of the contract research organizations listed on this map? By clicking on the company’s name, you will be directed to their supplier profile on the Scientist.com marketplace. Once you set up a marketplace account you can start the ordering process immediately.
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Information about my organization is incorrect, how do I fix it?
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