36 George Street Manchester, M1 4HA United KingdomhVIVO Services Limited is a full service early phase CRO, offering *Human Challenge Trials* as well as *infectious disease lab services and HBS* via hLAB, P*h1 Clinical Trials* via CRS and *Consulting and BioMetrics* services through Venn Life Sciences. *hLAB*, part of hVIVO, is a highly specialised *virology and immunology laboratory* designed to support virology drug and vaccine clinical trials, based and regulated in the UK. Specialising in Respiratory viruses: hMPV (human metapneumovirus), SARS-CoV-2 and variants, RSV(respiratory syncytial virus) A and B, influenza A and B, HRV (human rhinovirus), H5N1, H1N1,H3N2 but can support other virology studies including BSL-3 containment requirements including Dengue, including asthma and COPD patient cohorts and malaria. _An array of services_ *Molecular Biology* : ELISAs, qPCR, Cell based infectivity assays (e.g. microneutralisation assays(MNA), FRNA,HAI), ELISpot, multi-pathogen screening, TCID50 assays, Plaque Assays, Drug potency assays(IC50/IC90), viral resistance monitoring *Biomarker Analysis* : Multiplex Cytokine and chemokine analysis (on MSD platform) *Assay Development and Validation* : can help develop and validate an array of assays against BSL-2 and BSL-3 viruses *Human Biological Samples* : healthy and infected biofluids and PBMCs *Biobank Storage* : Biological and non-biological long term storage for trial samples, libraries and agents *Collection kits* : Creation and distribution of sample collection kits, including sample transport matrix and hLAB’s proprietary RSV stabilisation matrix, which is specifically designed to address the challenge of maintaining RSV sample integrity during storage and shipment. *hVIVO* The world’s leading specialist in human challenge trials. We specialise in infectious diseases, with a long standing expertise in respiratory viruses (RSV, Flu, hMPV, HRV etc) and Vaccine Development—supported by our state-of-the-art quarantine facility in London. *CRS Mannheim* Our Largest and Most Versatile Phase I/II Clinic, offering a total of 94 beds, including 58 dedicated to long-term stays. The facility also features multifunctional rooms, an 800 sqm outpatient area, and a large garden, making it highly adaptable to various trial designs. From first-in-human (FiH) trials to Proof-of-Concept (PoC) Phase IIa trials, our expertise spans cardiovascular, central nervous system, dermatology, ARDS, pain management (including narcotics), and more. *CRS Kiel* Specialised Renal and Hepatic Impairment Trials. We are dedicated to advancing therapies for kidney and liver diseases, including complex conditions where organ impairments impact standard of care. Our team specializes in the high-precision management of complex trial designs, including studies involving dose titration, diverse drug formulations and delivery methods, as well as food- and drug-interaction assessments. *Venn Life Sciences* Venn Life Sciences offers drug development consultancy and services to help bring products to the market quickly and efficiently. Venn’s capabilities and expertise includes CMC, Non-Clinical, Clinical Pharmacology and Development, Statistics, Study Design and Methodology, Data Management, RTSM and Regulatory Affairs across a wide variety of therapeutic areas. We have an extensive experience in discussing these development programs with global regulators. With our independent position we can design an optimal program including risk assessment and mitigation, saving time and money whilst achieving project milestone objectives. From Pre-clinical to Market authorisation.

Grenadierstr. 1 Mannheim, 68167 GermanyhVIVO Services Limited is a full service early phase CRO, offering *Human Challenge Trials* as well as *infectious disease lab services and HBS* via hLAB, P*h1 Clinical Trials* via CRS and *Consulting and BioMetrics* services through Venn Life Sciences. *hLAB*, part of hVIVO, is a highly specialised *virology and immunology laboratory* designed to support virology drug and vaccine clinical trials, based and regulated in the UK. Specialising in Respiratory viruses: hMPV (human metapneumovirus), SARS-CoV-2 and variants, RSV(respiratory syncytial virus) A and B, influenza A and B, HRV (human rhinovirus), H5N1, H1N1,H3N2 but can support other virology studies including BSL-3 containment requirements including Dengue, including asthma and COPD patient cohorts and malaria. _An array of services_ *Molecular Biology* : ELISAs, qPCR, Cell based infectivity assays (e.g. microneutralisation assays(MNA), FRNA,HAI), ELISpot, multi-pathogen screening, TCID50 assays, Plaque Assays, Drug potency assays(IC50/IC90), viral resistance monitoring *Biomarker Analysis* : Multiplex Cytokine and chemokine analysis (on MSD platform) *Assay Development and Validation* : can help develop and validate an array of assays against BSL-2 and BSL-3 viruses *Human Biological Samples* : healthy and infected biofluids and PBMCs *Biobank Storage* : Biological and non-biological long term storage for trial samples, libraries and agents *Collection kits* : Creation and distribution of sample collection kits, including sample transport matrix and hLAB’s proprietary RSV stabilisation matrix, which is specifically designed to address the challenge of maintaining RSV sample integrity during storage and shipment. *hVIVO* The world’s leading specialist in human challenge trials. We specialise in infectious diseases, with a long standing expertise in respiratory viruses (RSV, Flu, hMPV, HRV etc) and Vaccine Development—supported by our state-of-the-art quarantine facility in London. *CRS Mannheim* Our Largest and Most Versatile Phase I/II Clinic, offering a total of 94 beds, including 58 dedicated to long-term stays. The facility also features multifunctional rooms, an 800 sqm outpatient area, and a large garden, making it highly adaptable to various trial designs. From first-in-human (FiH) trials to Proof-of-Concept (PoC) Phase IIa trials, our expertise spans cardiovascular, central nervous system, dermatology, ARDS, pain management (including narcotics), and more. *CRS Kiel* Specialised Renal and Hepatic Impairment Trials. We are dedicated to advancing therapies for kidney and liver diseases, including complex conditions where organ impairments impact standard of care. Our team specializes in the high-precision management of complex trial designs, including studies involving dose titration, diverse drug formulations and delivery methods, as well as food- and drug-interaction assessments. *Venn Life Sciences* Venn Life Sciences offers drug development consultancy and services to help bring products to the market quickly and efficiently. Venn’s capabilities and expertise includes CMC, Non-Clinical, Clinical Pharmacology and Development, Statistics, Study Design and Methodology, Data Management, RTSM and Regulatory Affairs across a wide variety of therapeutic areas. We have an extensive experience in discussing these development programs with global regulators. With our independent position we can design an optimal program including risk assessment and mitigation, saving time and money whilst achieving project milestone objectives. From Pre-clinical to Market authorisation.

40 Bank Street London, England, E14 5NR United KingdomhVIVO Services Limited is a full service early phase CRO, offering *Human Challenge Trials* as well as *infectious disease lab services and HBS* via hLAB, P*h1 Clinical Trials* via CRS and *Consulting and BioMetrics* services through Venn Life Sciences. *hLAB*, part of hVIVO, is a highly specialised *virology and immunology laboratory* designed to support virology drug and vaccine clinical trials, based and regulated in the UK. Specialising in Respiratory viruses: hMPV (human metapneumovirus), SARS-CoV-2 and variants, RSV(respiratory syncytial virus) A and B, influenza A and B, HRV (human rhinovirus), H5N1, H1N1,H3N2 but can support other virology studies including BSL-3 containment requirements including Dengue, including asthma and COPD patient cohorts and malaria. _An array of services_ *Molecular Biology* : ELISAs, qPCR, Cell based infectivity assays (e.g. microneutralisation assays(MNA), FRNA,HAI), ELISpot, multi-pathogen screening, TCID50 assays, Plaque Assays, Drug potency assays(IC50/IC90), viral resistance monitoring *Biomarker Analysis* : Multiplex Cytokine and chemokine analysis (on MSD platform) *Assay Development and Validation* : can help develop and validate an array of assays against BSL-2 and BSL-3 viruses *Human Biological Samples* : healthy and infected biofluids and PBMCs *Biobank Storage* : Biological and non-biological long term storage for trial samples, libraries and agents *Collection kits* : Creation and distribution of sample collection kits, including sample transport matrix and hLAB’s proprietary RSV stabilisation matrix, which is specifically designed to address the challenge of maintaining RSV sample integrity during storage and shipment. *hVIVO* The world’s leading specialist in human challenge trials. We specialise in infectious diseases, with a long standing expertise in respiratory viruses (RSV, Flu, hMPV, HRV etc) and Vaccine Development—supported by our state-of-the-art quarantine facility in London. *CRS Mannheim* Our Largest and Most Versatile Phase I/II Clinic, offering a total of 94 beds, including 58 dedicated to long-term stays. The facility also features multifunctional rooms, an 800 sqm outpatient area, and a large garden, making it highly adaptable to various trial designs. From first-in-human (FiH) trials to Proof-of-Concept (PoC) Phase IIa trials, our expertise spans cardiovascular, central nervous system, dermatology, ARDS, pain management (including narcotics), and more. *CRS Kiel* Specialised Renal and Hepatic Impairment Trials. We are dedicated to advancing therapies for kidney and liver diseases, including complex conditions where organ impairments impact standard of care. Our team specializes in the high-precision management of complex trial designs, including studies involving dose titration, diverse drug formulations and delivery methods, as well as food- and drug-interaction assessments. *Venn Life Sciences* Venn Life Sciences offers drug development consultancy and services to help bring products to the market quickly and efficiently. Venn’s capabilities and expertise includes CMC, Non-Clinical, Clinical Pharmacology and Development, Statistics, Study Design and Methodology, Data Management, RTSM and Regulatory Affairs across a wide variety of therapeutic areas. We have an extensive experience in discussing these development programs with global regulators. With our independent position we can design an optimal program including risk assessment and mitigation, saving time and money whilst achieving project milestone objectives. From Pre-clinical to Market authorisation.

QMB Innovation Centre 42 New Road London, E1 2AX United KingdomhVIVO Services Limited is a full service early phase CRO, offering *Human Challenge Trials* as well as *infectious disease lab services and HBS* via hLAB, P*h1 Clinical Trials* via CRS and *Consulting and BioMetrics* services through Venn Life Sciences. *hLAB*, part of hVIVO, is a highly specialised *virology and immunology laboratory* designed to support virology drug and vaccine clinical trials, based and regulated in the UK. Specialising in Respiratory viruses: hMPV (human metapneumovirus), SARS-CoV-2 and variants, RSV(respiratory syncytial virus) A and B, influenza A and B, HRV (human rhinovirus), H5N1, H1N1,H3N2 but can support other virology studies including BSL-3 containment requirements including Dengue, including asthma and COPD patient cohorts and malaria. _An array of services_ *Molecular Biology* : ELISAs, qPCR, Cell based infectivity assays (e.g. microneutralisation assays(MNA), FRNA,HAI), ELISpot, multi-pathogen screening, TCID50 assays, Plaque Assays, Drug potency assays(IC50/IC90), viral resistance monitoring *Biomarker Analysis* : Multiplex Cytokine and chemokine analysis (on MSD platform) *Assay Development and Validation* : can help develop and validate an array of assays against BSL-2 and BSL-3 viruses *Human Biological Samples* : healthy and infected biofluids and PBMCs *Biobank Storage* : Biological and non-biological long term storage for trial samples, libraries and agents *Collection kits* : Creation and distribution of sample collection kits, including sample transport matrix and hLAB’s proprietary RSV stabilisation matrix, which is specifically designed to address the challenge of maintaining RSV sample integrity during storage and shipment. *hVIVO* The world’s leading specialist in human challenge trials. We specialise in infectious diseases, with a long standing expertise in respiratory viruses (RSV, Flu, hMPV, HRV etc) and Vaccine Development—supported by our state-of-the-art quarantine facility in London. *CRS Mannheim* Our Largest and Most Versatile Phase I/II Clinic, offering a total of 94 beds, including 58 dedicated to long-term stays. The facility also features multifunctional rooms, an 800 sqm outpatient area, and a large garden, making it highly adaptable to various trial designs. From first-in-human (FiH) trials to Proof-of-Concept (PoC) Phase IIa trials, our expertise spans cardiovascular, central nervous system, dermatology, ARDS, pain management (including narcotics), and more. *CRS Kiel* Specialised Renal and Hepatic Impairment Trials. We are dedicated to advancing therapies for kidney and liver diseases, including complex conditions where organ impairments impact standard of care. Our team specializes in the high-precision management of complex trial designs, including studies involving dose titration, diverse drug formulations and delivery methods, as well as food- and drug-interaction assessments. *Venn Life Sciences* Venn Life Sciences offers drug development consultancy and services to help bring products to the market quickly and efficiently. Venn’s capabilities and expertise includes CMC, Non-Clinical, Clinical Pharmacology and Development, Statistics, Study Design and Methodology, Data Management, RTSM and Regulatory Affairs across a wide variety of therapeutic areas. We have an extensive experience in discussing these development programs with global regulators. With our independent position we can design an optimal program including risk assessment and mitigation, saving time and money whilst achieving project milestone objectives. From Pre-clinical to Market authorisation.

Angel House 24 Station Road Ely, CB7 4BS United KingdomhVIVO Services Limited is a full service early phase CRO, offering *Human Challenge Trials* as well as *infectious disease lab services and HBS* via hLAB, P*h1 Clinical Trials* via CRS and *Consulting and BioMetrics* services through Venn Life Sciences. *hLAB*, part of hVIVO, is a highly specialised *virology and immunology laboratory* designed to support virology drug and vaccine clinical trials, based and regulated in the UK. Specialising in Respiratory viruses: hMPV (human metapneumovirus), SARS-CoV-2 and variants, RSV(respiratory syncytial virus) A and B, influenza A and B, HRV (human rhinovirus), H5N1, H1N1,H3N2 but can support other virology studies including BSL-3 containment requirements including Dengue, including asthma and COPD patient cohorts and malaria. _An array of services_ *Molecular Biology* : ELISAs, qPCR, Cell based infectivity assays (e.g. microneutralisation assays(MNA), FRNA,HAI), ELISpot, multi-pathogen screening, TCID50 assays, Plaque Assays, Drug potency assays(IC50/IC90), viral resistance monitoring *Biomarker Analysis* : Multiplex Cytokine and chemokine analysis (on MSD platform) *Assay Development and Validation* : can help develop and validate an array of assays against BSL-2 and BSL-3 viruses *Human Biological Samples* : healthy and infected biofluids and PBMCs *Biobank Storage* : Biological and non-biological long term storage for trial samples, libraries and agents *Collection kits* : Creation and distribution of sample collection kits, including sample transport matrix and hLAB’s proprietary RSV stabilisation matrix, which is specifically designed to address the challenge of maintaining RSV sample integrity during storage and shipment. *hVIVO* The world’s leading specialist in human challenge trials. We specialise in infectious diseases, with a long standing expertise in respiratory viruses (RSV, Flu, hMPV, HRV etc) and Vaccine Development—supported by our state-of-the-art quarantine facility in London. *CRS Mannheim* Our Largest and Most Versatile Phase I/II Clinic, offering a total of 94 beds, including 58 dedicated to long-term stays. The facility also features multifunctional rooms, an 800 sqm outpatient area, and a large garden, making it highly adaptable to various trial designs. From first-in-human (FiH) trials to Proof-of-Concept (PoC) Phase IIa trials, our expertise spans cardiovascular, central nervous system, dermatology, ARDS, pain management (including narcotics), and more. *CRS Kiel* Specialised Renal and Hepatic Impairment Trials. We are dedicated to advancing therapies for kidney and liver diseases, including complex conditions where organ impairments impact standard of care. Our team specializes in the high-precision management of complex trial designs, including studies involving dose titration, diverse drug formulations and delivery methods, as well as food- and drug-interaction assessments. *Venn Life Sciences* Venn Life Sciences offers drug development consultancy and services to help bring products to the market quickly and efficiently. Venn’s capabilities and expertise includes CMC, Non-Clinical, Clinical Pharmacology and Development, Statistics, Study Design and Methodology, Data Management, RTSM and Regulatory Affairs across a wide variety of therapeutic areas. We have an extensive experience in discussing these development programs with global regulators. With our independent position we can design an optimal program including risk assessment and mitigation, saving time and money whilst achieving project milestone objectives. From Pre-clinical to Market authorisation.