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Manassa, VAThe Center for the Study of Chronic Metabolic and Rare Diseases (CSCMRD) employs Systems Biology perspective for functional analysis of diverse experimental data In particular, Centers faculty are interested in the development of relevant biomarkers for longitudinal monitoring for patients with various kinds of illnesses, both multifactorial and genetically defined, and pathophysiological models that adequately describe these disease. Moreover, we a interested in overall metabolic sliding associated with ageing. The metabolic footprints of the body are amenable for correction, either with pharmacological interventions, or with the changes in lifestyle and diet. One of important goal of the center is to apply systems biology approaches to analyze available biological data collected using high-throughput platforms and to develop a set of user-friendly bioinformatics tools and comprehensive databases capturing clinical and experimental data. An intention for this set of tools is to assist in discovery of novel biomarkers and in design of targeted drugs with potential efficacy to treat human diseases, including the rare and orphan diseases. CSCMRD is a model of collaborative research that bridges the excellence in clinical care and research of Inova Fairfax Hospital with the excellence in basic/genomic research available at George Mason University. CSCMRD had established both local and global networks of collaboration including the Organization for Rare Diseases India founder Dr. Harsha Rajasimha and the ORDIs US subsidiary in Fairfax VA. ORDI serves as an umbrella organization representing the collective voice of patients and other stakeholders of rare diseases in India. ORDI brings expertise and leadership in genomics, bioinformatics, information technology, patient advocacy, and public health policy for rare diseases research.
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