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60, Avenue Rockefeller BioParc, Bioserra 1 Lyon, 69008 FranceSPECIALIZED HIT GENERATION & MEDICINAL CHEMISTRY SERVICES Edelris provides innovative drug discovery solutions, leveraging a unique "Natural-by-Design" philosophy to bridge the gap between flat synthetic libraries and complex natural products. We deliver high-quality, tractable hits and expert medicinal chemistry to accelerate your programs from Fragment-Based Lead Discovery to Lead Optimization. HIT GENERATION SOLUTIONS We offer three distinct pillars for identifying high-quality starting points: - Keymical Fragments (FBLD/FBDD): Premium, non-exclusive 3D fragments designed for high tractability. These innovative compounds are purely synthetic yet mimic natural complexity, ensuring reliable SAR follow-up from commercially available starting materials. Proven Success: Validated in numerous client FBS campaigns. - Keymical Collections (HTS): Non-exclusive, 3D lead-like series optimized for HTS. Our "Natural-by-Design" approach ensures these compounds occupy a unique chemical space compared to traditional libraries. - EDEN (Edelris Discovery ENgine): An integrated platform for efficient ligand identification using AS-MS (Affinity Selection-Mass Spectrometry). Largest Commercially Available AS-MS Screening Library: 2 million compounds from our proprietary Keymical Space. Versatility: Successfully screened dozens of targets, including Enzymes (soluble and membrane proteins), Native GPCRs, RNA, and Protein-Protein Interactions (PPIs). Flexibility: We can also screen client-provided decks (blinded if required). HIT-TO-LEAD & LEAD OPTIMIZATION Edelris provides track-proven Medicinal Chemistry services characterized by speed, cost-efficiency, and expert design. We act as a seamless extension of your team to reach your defined biological profile. - Hit Exploration & Fast Follow-up: Rapid library synthesis to validate hits. - Iterative Optimization Loops: Design-Make-Test cycles focused on potency, selectivity, and ADME properties. Why Choose Edelris? - 3D Complexity: Moving beyond "flat" chemistry for better target binding. - Tractability: All compounds are designed for easy synthetic follow-up from commercially accessible materials. - Expertise: Deep experience across diverse and challenging target classes (Enzymes, GPCRs, RNA, PPIs). ---------------------------------------------------------------------------------------------------------------------- REFERENCES, CASE STUDIES, and KEY PUBLICATIONS Keymical Fragments (FBLD/FBDD): - BMCL, 2019 : https://doi.org/10.1016/j.bmcl.2019.126717 - Practical Fragments Feature : http://practicalfragments.blogspot.com/2020/01/three-dimensional-fragments-revisited.html Keymical Collections (HTS): - Waldmann et al., Angew. Chem. Int. Ed. 2019 : https://doi.org/10.1002/anie.201909819 EDEN, the Edelris Discovery ENgine (AS-MS Screening): - ChemRxiv, 2026 : https://doi.org/10.26434/chemrxiv-2026-6xtxm - Nature Reviews Chemistry, 2020 : https://doi.org/10.1038/s41570-020-00229-2 Hit-to-Lead & Lead Optimization: - Nucleic Acids Research, 2024 : https://doi.org/10.1093/nar/gkae897 - ACS Chem. Biol. 2017 : https://doi.org/10.1021/acschembio.7b00708
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