760 Parkside Avenue Suite #321 Brooklyn, NY, 11226 United StatesXylyx Bio's mission is to increase predictiveness and confidence in drug discovery for cancer, fibrosis, and other devastating diseases through our physiologically-relevant IN MATRICO™ platform. Our platform technology incorporates human tissue and disease-specific extracellular matrix substrates combined with clinically relevant data packages to enable drug candidates to be tested IN MATRICO™ to inform better decision making in drug discovery. Tissue-specific ECM substrates enable high-fidelity disease models that reflect human disease biology and are provided in both 2D and 3D product formats that are compatible with low and high throughput screening. Xylyx Bio also offers IN MATRICO™ compound testing services to accurately predict in-vivo drug response. Xylyx Bio offers custom fibrotic human lung and liver ECM substrates to significantly improve in-vitro disease modeling and drug development in a disease-relevant setting. Our fibrosis-specific extracellular matrix products benefit drug discovery programs by enabling drug candidates to be investigated in a disease-relevant in-vitro environment that recapitulates human fibrosis, yielding new insights into fibrotic mechanisms and guiding decision-making through therapeutic development. NativeCoat™ ECM Surface Coating is a solubilized form of the extracellular matrix from native organs. NativeCoat™ ECM Coatings contain tissue-specific or disease-specific ECM components and signals that recapitulate the native cell environment in vitro. Apply NativeCoat™ ECM in 2D cell culture to coat any cell culture surface and provide cells with key physiological factors that regulate cell growth and function. Coating with tissue-specific biochemical composition of the native cell microenvironment results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways. TissueSpec® ECM Hydrogels provide a soft, physiological substrate for 3D cell culture. TissueSpec® Hydrogels enhance cell attachment, cell-cell interaction, and cell expansion. TissueSpec® Hydrogels applied in 3D cell culture as thin gels to cover cell culture surfaces or as thick gels to encapsulate cells or organoids within a 3D tissue-specific ECM environment. TissueSpec® ECM Scaffolds are acellular constructs that retain the natural 3D biomechanics and structural topography of native tissues. Preserved tissue components, such as vascular structures, constitute key features of the native tissue architecture. TissueSpec® ECM Scaffolds are applied in 3D cell culture or tissue engineering to study the effects of native tissue mechanics on the differentiation or migration of cells.

760 Parkside Avenue Suite #321 Brooklyn, New York, 11226 United StatesXylyx Bio's mission is to increase predictiveness and confidence in drug discovery for cancer, fibrosis, and other devastating diseases through our physiologically-relevant IN MATRICO™ platform. Our platform technology incorporates human tissue and disease-specific extracellular matrix substrates combined with clinically relevant data packages to enable drug candidates to be tested IN MATRICO™ to inform better decision making in drug discovery. Tissue-specific ECM substrates enable high-fidelity disease models that reflect human disease biology and are provided in both 2D and 3D product formats that are compatible with low and high throughput screening. Xylyx Bio also offers IN MATRICO™ compound testing services to accurately predict in-vivo drug response. Xylyx Bio offers custom fibrotic human lung and liver ECM substrates to significantly improve in-vitro disease modeling and drug development in a disease-relevant setting. Our fibrosis-specific extracellular matrix products benefit drug discovery programs by enabling drug candidates to be investigated in a disease-relevant in-vitro environment that recapitulates human fibrosis, yielding new insights into fibrotic mechanisms and guiding decision-making through therapeutic development. NativeCoat™ ECM Surface Coating is a solubilized form of the extracellular matrix from native organs. NativeCoat™ ECM Coatings contain tissue-specific or disease-specific ECM components and signals that recapitulate the native cell environment in vitro. Apply NativeCoat™ ECM in 2D cell culture to coat any cell culture surface and provide cells with key physiological factors that regulate cell growth and function. Coating with tissue-specific biochemical composition of the native cell microenvironment results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways. TissueSpec® ECM Hydrogels provide a soft, physiological substrate for 3D cell culture. TissueSpec® Hydrogels enhance cell attachment, cell-cell interaction, and cell expansion. TissueSpec® Hydrogels applied in 3D cell culture as thin gels to cover cell culture surfaces or as thick gels to encapsulate cells or organoids within a 3D tissue-specific ECM environment. TissueSpec® ECM Scaffolds are acellular constructs that retain the natural 3D biomechanics and structural topography of native tissues. Preserved tissue components, such as vascular structures, constitute key features of the native tissue architecture. TissueSpec® ECM Scaffolds are applied in 3D cell culture or tissue engineering to study the effects of native tissue mechanics on the differentiation or migration of cells.