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Charitéplatz 1 Virchowweg 12 Berlin, Berlin, 10117 GermanyThe German Rheumatology Research Center (DRFZ) is a non-profit foundation and a member of the Leibniz Association since 2009, jointly funded by Germany’s federal and regional governments. At DRFZ, we conduct cutting-edge research into the causes of rheumatic diseases to develop innovative and personalized therapies. Utilizing state-of-the-art technologies such as artificial intelligence and biomarker analysis, we strive for more precise diagnoses and effective treatments. Our Personalized Medicine Project is dedicated to deeply characterizing the immune mechanisms driving disease in individual patients. By accessing patients who are freshly diagnosed and have not yet received disease-specific therapies, we aim to capture an undistorted view of their immune system at a critical juncture—before therapeutic interventions alter their immune profile. To achieve this, we employ high-level proteomic and genomic analyses of patient-derived body fluids. A key component of this strategy is the whole blood activation assay, providing a functional readout of immune reactivity under near-physiological conditions. By stimulating whole blood ex vivo with defined immune triggers, we observe real-time immune responses in a complex, intact cellular environment. This approach helps us understand baseline immune activation and how patients’ immune systems respond to specific stimuli. Our ultimate goal is to identify patient-specific immune pathway signatures that can inform targeted, individualized treatment strategies, moving beyond a one-size-fits-all paradigm toward precise, mechanism-based therapy selection tailored to each patient’s unique disease biology. Services offered: - Immune Phenotyping and Profiling: We offer comprehensive immune phenotyping and profiling services using our established Standard Operating Procedures (SOPs), including advanced techniques like mass cytometry, which allows for deep cellular phenotyping with the measurement of over 50 parameters simultaneously . - Compound Influence Characterization: Our team specializes in characterizing the influence of specific compounds on immune responses. We assess how various substances affect immune cell behavior and function, providing insights into their potential therapeutic applications. - Agonistic and Antagonistic Effect Analysis: We investigate the agonistic or antagonistic effects of specific compounds on immune pathway functions. This includes evaluating how compounds modulate immune signaling pathways, which is crucial for drug development and understanding immune modulation mechanisms. Our services are designed to support researchers and pharmaceutical partners in advancing personalized medicine approaches, facilitating the development of targeted therapies based on individual immune profiles.
Virchowweg 12 Warenannahme MPI/DRFZ Berlin, Berlin, 10115 GermanyThe German Rheumatology Research Center (DRFZ) is a non-profit foundation and a member of the Leibniz Association since 2009, jointly funded by Germany’s federal and regional governments. At DRFZ, we conduct cutting-edge research into the causes of rheumatic diseases to develop innovative and personalized therapies. Utilizing state-of-the-art technologies such as artificial intelligence and biomarker analysis, we strive for more precise diagnoses and effective treatments. Our Personalized Medicine Project is dedicated to deeply characterizing the immune mechanisms driving disease in individual patients. By accessing patients who are freshly diagnosed and have not yet received disease-specific therapies, we aim to capture an undistorted view of their immune system at a critical juncture—before therapeutic interventions alter their immune profile. To achieve this, we employ high-level proteomic and genomic analyses of patient-derived body fluids. A key component of this strategy is the whole blood activation assay, providing a functional readout of immune reactivity under near-physiological conditions. By stimulating whole blood ex vivo with defined immune triggers, we observe real-time immune responses in a complex, intact cellular environment. This approach helps us understand baseline immune activation and how patients’ immune systems respond to specific stimuli. Our ultimate goal is to identify patient-specific immune pathway signatures that can inform targeted, individualized treatment strategies, moving beyond a one-size-fits-all paradigm toward precise, mechanism-based therapy selection tailored to each patient’s unique disease biology. Services offered: - Immune Phenotyping and Profiling: We offer comprehensive immune phenotyping and profiling services using our established Standard Operating Procedures (SOPs), including advanced techniques like mass cytometry, which allows for deep cellular phenotyping with the measurement of over 50 parameters simultaneously . - Compound Influence Characterization: Our team specializes in characterizing the influence of specific compounds on immune responses. We assess how various substances affect immune cell behavior and function, providing insights into their potential therapeutic applications. - Agonistic and Antagonistic Effect Analysis: We investigate the agonistic or antagonistic effects of specific compounds on immune pathway functions. This includes evaluating how compounds modulate immune signaling pathways, which is crucial for drug development and understanding immune modulation mechanisms. Our services are designed to support researchers and pharmaceutical partners in advancing personalized medicine approaches, facilitating the development of targeted therapies based on individual immune profiles.
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