WeWork Room 201, Block B 135 Yanping Road Shanghai, Jing'an District ChinaCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

55, Old Broad Street London, EC2M 1RX United KingdomCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

1 New York Street Manchester , M1 4HD United KingdomCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

1 Victoria Street Bristol, BS1 6AA United KingdomCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

Floor 16, 175 Federal St Boston, MA, 02110 United StatesCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

50/60 Station Road Cambridge, CB1 2JH United KingdomCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

6 Shenton Way OUE Downtown 2, #20-08 Singapore, 068809 United KingdomCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.

6 Shenton Way OUE Downtown 2, #20-08 Singapore, 068809 SingaporeCostello Medical is an award winning, independent, global healthcare agency specialising in medical communications, market access and HEOR. Since our founding in 2008, we have grown organically to a team of more than 500 colleagues, supporting over 300 different client organisations globally, from our offices based in the UK, US, Canada, Singapore and China. As an independent agency we are not beholden to external shareholders, allowing us to remain fully client-focused, flexible in how we work, and uncompromising on scientific quality. Together, our global presence, diverse scientific expertise, values driven culture and award winning performance position Costello Medical as a trusted, long term partner for organisations seeking strategic insights coupled with excellent scientific support across the healthcare sector. Our core service offerings are as follows: Medical Communications Our Medical Communications services cover publications, medical affairs, and creative support. We provide publications development, planning and consultancy, enhanced content such as infographics, videos and podcasts, and policy reports. Medical affairs work includes strategy development, omnichannel delivery, scientific exchange, insight gathering through advisory boards, surveys and Delphi panels, and congress engagement such as symposia and scientific coverage. Creative services span graphic, digital and motion design, branding, web and app development, and interactive experiences. We also deliver commercial and marketing support including brand positioning, launch communications, promotional materials, congress resources and disease awareness campaigns. Evidence Development Our Evidence Development services cover literature reviews, statistics and real-world evidence. Literature review expertise includes systematic, pragmatic, rapid and scoping reviews, as well as strategic evidence reviews, competitor intelligence and gap analyses. Statistics support spans analysis plan development, meta-analyses, indirect treatment comparisons, trial and utility analyses, survival modelling and epidemiology, with training and publications support also provided. Real-world evidence services include study design and analysis across databases, registries, electronic health records, observational studies, surveys, qualitative research and expert elicitation, alongside strategic evidence generation planning, data source mapping and dissemination through publications. Value and Access Our Value and Access services cover health economics, health technology assessment and market access. Our health economics services include cost-effectiveness and budget impact models, feasibility assessments, early modelling, technical validation, customer-facing interactive tools, advisory boards and training. HTA support includes strategy development, multi-country HTA submissions, JCA activities, early Scientific Advice, mock stakeholder meetings, payer and clinician advisory boards, training and HEOR publications. We also provide market access strategy and planning, the development of global, regional and local value dossiers, value propositions and messaging, roll-out workshops and objection handlers, as well as local country-specific resources such as AMCP dossiers, interactive tools, brochures, ABN materials and formulary packs. Health Policy & Public Affairs Our Health Policy and Public Affairs services cover the preparation of white papers, position papers, policy briefs, roundtable reports and policy research reports. We also produce best practice, consensus and recommendation articles, expert opinion papers and options appraisals. In addition, we can support multi-stakeholder engagement through Delphi panels, surveys, focus groups, interviews, policy landscape mapping, stakeholder mapping, roundtables and steering committees. Our services also include the creation of advocacy toolkits and policy campaign materials. We also have a dedicated Patient Engagement team who deliver patient engagement activities such as landscape assessments, strategic recommendations, surveys, advisory boards and workshops, as well as the development of patient information, education and support resources and communication of patient commitments. In addition, we collaborate with government bodies and public institutions to deliver policy research, healthcare evaluation projects and strategic initiatives. MedTech and Rare Diseases Expertise In addition to our experience in all major therapeutic areas, we have dedicated MedTech and Rare Diseases teams who work seamlessly across all of our teams with specialist knowledge of the challenges and nuances inherent to MedTech products and rare and ultra-rare diseases.