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Impasse des Sources Ruffieux, Auvergne-Rhône-Alpes, 73310 FranceCellMade is a biopharmaceutical company focused on the development and commercialization of early diagnostic and prognostic tests and novel therapeutics to prevent development of Metabolic Disease and related co-morbidities. The ever-increasing prevalence of Obesity affects millions of people worldwide. The Metabolic Syndrome and its hepatic manifestation, NAFLD-NASH is a key pathological condition triggered by the noxious biochemical pathways of Obesity. Despite the high unmet medical needs, there are currently no approved drugs for treating NAFLD-NASH. The current main recommendation is lifestyle modification, which is only partially effective. The scientific evidence on the looming pandemic of Obesity is now overwhelming. It is thought that the spreading of the disease is mediated via circulating inflammatory messengers. As in any degenerative disease, early diagnosis is the key to avoid harmful, and even deadly, effects. There is high demand for a non-invasive, high-accuracy diagnostic and prognostic approach. CellMade identified and validated a set of blood lipids that allow for discrimination between the various stages of NAFLD-NASH enabling to predict patient's risk profile and reactivity to treatment schedules. The successful validation of the biomarker signatures represents a cornerstone advancement to address the societal challenges related to the Obesity pandemic and the development of associated comorbidities such as T2DM, CVD and COPD. Early diagnosis will overcome the costs issues affecting the current clinical scenario, as the disease development is still reversible and could be addressed therapeutically. We at CellMade believe in Open Innovation and therefore established a dedicated range of laboratory services, derived from our own research activities, that can help scientists in further developing tools for Metabolic Disease. Our multidisciplinary team has developed an innovative systems biology approach enabling high-content and robust analysis of cell models required for a diverse range of applications such as efficacy and safety testing of new drug compounds or the discovery of biomarkers. CellMade provides a comprehensive catalog of Services: Biobanking, Cell-based assays, Cytometry and Mass Spectrometry assays and Bioinformatics for annotation of obtained data and construction of data-bases.
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