The Dorothy Hodgkin Building Babraham Research Campus Cambridge, CB22 3FH United Kingdombit.bio provides human iPSC-derived cells and related services for research, drug discovery, and toxicology. Using a deterministic cell programming approach, bit.bio produces defined human neurons, glial cells, muscle cells and hepatocytes that enable researchers to work with physiologically relevant human models. Cells are supplied cryopreserved and can be used in experiments within days, supporting reproducible and scalable in vitro studies. The cells are generated using opti-ox™, a transcription factor-based cell programming technology that precisely controls gene expression in human induced pluripotent stem cells (iPSCs). This deterministic approach converts stem cells into a single defined cell type rapidly and consistently, avoiding the heterogeneity and long timelines often associated with traditional differentiation methods. bit.bio cells are used in drug discovery workflows including disease modelling, target validation, and safety assessment. Researchers use these human cell models to study neurodegeneration, neuromuscular biology and metabolism, and to run screening workflows such as electrophysiology assays (including MEA and patch clamp), CRISPR screening and high-throughput compound screening and safety or toxicity studies. In addition to supplying ready-to-use human cell models, bit.bio also supports custom cell engineering, CRISPR-based screening and small molecule screening projects. induced pluripotent stem cells iPSC-derived cells human stem cell models Human cells cellular reprogramming transcription factor programming forward programming stem cell differentiation human neurons glutamatergic neurons Excitatory neurons GABAergic neurons Inhibitory neurons motor neurons sensory neurons microglia astrocytes oligodendrocytes oligodendrocyte precursor cells OPCs glial cells human hepatocytes Human liver cells skeletal muscle cells human myocytes disease modeling target validation pathway analysis functional genomics phenotypic screening high-throughput screening compound screening CRISPR screening genetic perturbation screening electrophysiology multi-electrode array MEA assays patch clamp hepatotoxicity drug-induced liver injury DILI neurotoxicity safety pharmacology cytotoxicity drug metabolism CYP induction CYP inhibition metabolic stability neuronal culture neuron-glia co-culture 3D cell culture neuroscience neurobiology neurodegeneration cell biology stem cell biology functional genomics Disease model cells amyotrophic lateral sclerosis ALS models ALS frontotemporal dementia FTD models FTD Motor neuron disease MND Parkinson's disease Parkinson’s models PD Huntington's disease Huntington’s disease models HD Alzheimer's disease Alzheimer’s disease models AD neurodegenerative disease Multiple sclerosis Demyelinating disease Duchenne muscular dystrophy DMD neuromuscular disease muscle biology muscle disease DMD models liver biology metabolism research metabolic disease drug metabolism