Palle Juul-Jensens Blvd 82 Aarhus, 8200 DenmarkBioXpedia A/S is a contract research laboratory focused on providing high-quality and cost-effective bioanalytical services. Our expertise lies in high-throughput sample preparation and multiomic screening and analyses across various biological levels. We pride ourselves on offering rapid and efficient analyses using multiplex low-volume technologies, maximising the use of your valuable samples. In addition to our laboratory services, we provide biostatistical analyses to extract more information from your data. At BioXpedia, we handle various types of extractions, including RNA, DNA, and protein, from diverse sample types such as tissue, blood, cell-free specimens, and FFPE. Whenever possible, we utilise automated pipetting and perform quality control on all samples prior to analysis. On the DNA level, we specialize in SNP genotyping using the Fluidigm system, which enables high-throughput analysis with low sample requirements. We also offer unrivalled precision and sensitivity using digital PCR (dPCR). By partitioning samples into individual sub-nanolitre volume reactions and counting positive and negative reactions, we can do rare mutation detection, assess gene expression, determine copy number. For gene expression analyses, we offer NanoString nCounter gene expression panels that focus on disease-related genes. This technology relies on the hybridization of target-specific probes without the need for enzymes. Alternatively, gene expression analysis can also be performed on the Fluidigm system or QuantStudio, allowing flexibility in the number of assays or samples. For protein biomarker screening, we offer the exceptional Olink Immuno-PCR Assays. These assays enable high-throughput, multiplex immunoassay panels capable of measuring close to 3000 proteins across 88 samples simultaneously, using only one microliter of serum or plasma. Additionally, we provide absolute protein quantification through Meso Scale Discovery (MSD) and ELISA. With two dedicated cell laboratories, BioXpedia offers diverse services including peripheral blood mononuclear cells (PBMC) collection, antisense oligonucleotide (ASO) screening, toxicity assays, EdU Cell Proliferation, and gymnosis/transfection. Our fully equipped, spatially separated labs ensure uninterrupted service and efficient project management. We offer isolation and culture of a range of primary cells, tailoring projects to meet your specific needs In 2023 BioXpedia expanded its service portfolio, adding pharmacokinetics (PK) and various animal models in rats and mice to our repertoire of services. As a result, we now offer specialised dosing and sampling protocols in rodents, as well as select disease models for neurological diseases, cancers, and lifestyle diseases. Besides validated models, we offer to develop models in collaboration with our sponsors. BioXpedia offers small molecule LC-MS services for precise analysis of various sample types. With our liquid chromatography-mass spectrometry (LC-MS) platform, we specialize in conducting pharmacokinetic and pharmacodynamic studies in rats and mice. Our expertise includes analysing tissues and biofluids, providing valuable insights into drug absorption, distribution, metabolism, and elimination. Our biostatistical services include a standard package covering basic normalization and identification of significant differences between groups. We also offer custom-tailored packages for more advanced experimental setups or when more detailed statistics are required. Founded in 2016 by Mogens Kruhøffer, who was also a co-founder of AROS Applied Biotechnology in 2000, BioXpedia is situated in Incuba Science Park, in close proximity to Aarhus University Hospital, Denmark.