7-9 rue Jean-Louis Bertrand RENNES, 35000 FranceBiotrial is a leading CRO specializing in Drug Development with a wide range of expertise in Preclinical Pharmacology, Clinical Development (Phase I studies with healthy volunteers/special populations, studies with patients), Bioanalysis, Biometrics, ECG, CNS & Imaging Core Lab. Biotrial performs hundreds of studies each year and offers tailor-made solutions to biotechnology and pharmaceutical industry. Biotrial’s preclinical pharmacology unit offers a comprehensive range of services to support the drug discovery and development process, from in vitro to in vivo pharmacology studies. Our team of experienced scientists has over 35 years of experience in designing and conducting preclinical studies, and we are committed to providing our clients with the highest quality data and support. Our state-of-the-art, 27,000-square-foot preclinical facility is AAALAC and GLP accredited, and equipped to work with a wide range of species, including rodents, dogs, mini-pigs, and non-human primates. Our drug efficacy services assess the therapeutic potential of the drug candidate using a diverse range of disease models. We execute studies that measure the effects of the drug on disease-related biomarkers and endpoints. Our drug efficacy services include in-vitro assays, in-vivo models and translation studies between preclinical findings and clinical applications. Our drug safety services are dedicated to evaluating the safety profile of the drug candidate using animal models. Our drug safety services include safety pharmacology to assess the potential effects of the drug on vital organ systems and safety de-risking to mitigate risks, minimize time delays and reduce costs. Our pharmacokinetics services assess the absorption, distribution metabolism and excretion of drug candidates. We measure the concentration of the drug in blood and tissues over time and provide critical insight to optimize the drug development. We assess the pharmacokinetics of the drug candidate in rodents and non-rodents to determine optimal dosing and formulation. We use pharmacokinetic data to develop models that predict the concentration of the drug in blood and tissues over time. Our in-vivo pharmacokinetics uses advanced analysis methods (non-compartmental analysis NCA, compartmental analysis CA, mechanism understanding, pharmacokinetics-pharmacodynamic analysis, population pharmacokinetics) and safety de-risking. Our model development services help select and develop the best animal models for drug discovery and its development. We have expertise in disease modeling, pharmacology design, model validation and model selection.

Temple Chambers 3-7 Temple Avenue London, EC4Y 0HP United KingdomBiotrial is a leading CRO specializing in Drug Development with a wide range of expertise in Preclinical Pharmacology, Clinical Development (Phase I studies with healthy volunteers/special populations, studies with patients), Bioanalysis, Biometrics, ECG, CNS & Imaging Core Lab. Biotrial performs hundreds of studies each year and offers tailor-made solutions to biotechnology and pharmaceutical industry. Biotrial’s preclinical pharmacology unit offers a comprehensive range of services to support the drug discovery and development process, from in vitro to in vivo pharmacology studies. Our team of experienced scientists has over 35 years of experience in designing and conducting preclinical studies, and we are committed to providing our clients with the highest quality data and support. Our state-of-the-art, 27,000-square-foot preclinical facility is AAALAC and GLP accredited, and equipped to work with a wide range of species, including rodents, dogs, mini-pigs, and non-human primates. Our drug efficacy services assess the therapeutic potential of the drug candidate using a diverse range of disease models. We execute studies that measure the effects of the drug on disease-related biomarkers and endpoints. Our drug efficacy services include in-vitro assays, in-vivo models and translation studies between preclinical findings and clinical applications. Our drug safety services are dedicated to evaluating the safety profile of the drug candidate using animal models. Our drug safety services include safety pharmacology to assess the potential effects of the drug on vital organ systems and safety de-risking to mitigate risks, minimize time delays and reduce costs. Our pharmacokinetics services assess the absorption, distribution metabolism and excretion of drug candidates. We measure the concentration of the drug in blood and tissues over time and provide critical insight to optimize the drug development. We assess the pharmacokinetics of the drug candidate in rodents and non-rodents to determine optimal dosing and formulation. We use pharmacokinetic data to develop models that predict the concentration of the drug in blood and tissues over time. Our in-vivo pharmacokinetics uses advanced analysis methods (non-compartmental analysis NCA, compartmental analysis CA, mechanism understanding, pharmacokinetics-pharmacodynamic analysis, population pharmacokinetics) and safety de-risking. Our model development services help select and develop the best animal models for drug discovery and its development. We have expertise in disease modeling, pharmacology design, model validation and model selection.