1 Røvedvej Trige, 8380 DenmarkBiotest Facility is a Danish-based CRO conducting test assays and studies, with focus on early preclinical in vivo pharmacology. The full service includes design, conduct, and reporting of studies. The test systems range from in vitro systems based on cells in culture to in vivo models for pharmacological and translational research. We offer classical pharmacology tests and integrated approaches and packages, e.g. including PK, toxicity testing, and PD for a range of disease models. We have the readiness and infrastructure to start special projects, as we did for test of radiotherapeutics, a now established service product. Biotest Facility is a new company with an experienced staff and extended network of suppliers and consultants from academia, biotech, and pharma industry. “We are driven by the passion for science, the delivery of accurate and cost-effective solutions for validation of life science concepts. With a dedicated cell laboratory, Biotest Facility offers diverse services including peripheral blood mononuclear cells (PBMC) collection, antisense oligonucleotide (ASO) screening, toxicity assays, EdU Cell Proliferation, and gymnosis/transfection. Our fully equipped, spatially separated labs ensure uninterrupted service and efficient project management. We offer isolation and culture of a range of primary cells, tailoring projects to meet your specific needs. Biotest Facility enhanced significantly skills in the field of biomarker discovery, and advanced proteomics by the integration of BioXpedia in 2024. Building on BioXpedia’s established expertise since 2016, we have developed extensive experience in high-throughput proteomic technologies, including Olink’s proximity extension assay (PEA) platform. Our team has successfully conducted numerous Olink-based studies, focusing on identifying and quantifying modulated proteins in various biological samples, such as plasma. We are proficient in generating high-quality NPX data, including NGS-based outputs, and are equipped to manage complex projects from study design through to data analysis and reporting. At Biotest Facility, we handle various types of extractions, including RNA, DNA, and protein, from diverse sample types such as tissue, blood, cell-free specimens, and FFPE. Whenever possible, we utilise automated pipetting and perform quality control on all samples prior to analysis. Biotest Facility does also offer a number of down-stream analyses such as small molecule LC-MS services for precise analysis of various sample types. With our liquid chromatography-mass spectrometry (LC-MS) platform, we specialize in conducting pharmacokinetic and pharmacodynamic studies in rats and mice. Our expertise includes analysing tissues and biofluids, providing valuable insights into drug absorption, distribution, metabolism, and elimination. On the DNA level, we specialize in SNP genotyping using the Fluidigm system, which enables high-throughput analysis with low sample requirements. We also offer unrivalled precision and sensitivity using digital PCR (dPCR). By partitioning samples into individual sub-nanolitre volume reactions and counting positive and negative reactions, we can do rare mutation detection, assess gene expression, determine copy number. For gene expression analyses, we offer NanoString nCounter gene expression panels that focus on disease-related genes. This technology relies on the hybridization of target-specific probes without the need for enzymes. Alternatively, gene expression analysis can also be performed on the Fluidigm system or QuantStudio, allowing flexibility in the number of assays or samples.

Roevedvej 1 Trige, DK-8380 DenmarkBiotest Facility is a Danish-based CRO conducting test assays and studies, with focus on early preclinical in vivo pharmacology. The full service includes design, conduct, and reporting of studies. The test systems range from in vitro systems based on cells in culture to in vivo models for pharmacological and translational research. We offer classical pharmacology tests and integrated approaches and packages, e.g. including PK, toxicity testing, and PD for a range of disease models. We have the readiness and infrastructure to start special projects, as we did for test of radiotherapeutics, a now established service product. Biotest Facility is a new company with an experienced staff and extended network of suppliers and consultants from academia, biotech, and pharma industry. “We are driven by the passion for science, the delivery of accurate and cost-effective solutions for validation of life science concepts. With a dedicated cell laboratory, Biotest Facility offers diverse services including peripheral blood mononuclear cells (PBMC) collection, antisense oligonucleotide (ASO) screening, toxicity assays, EdU Cell Proliferation, and gymnosis/transfection. Our fully equipped, spatially separated labs ensure uninterrupted service and efficient project management. We offer isolation and culture of a range of primary cells, tailoring projects to meet your specific needs. Biotest Facility enhanced significantly skills in the field of biomarker discovery, and advanced proteomics by the integration of BioXpedia in 2024. Building on BioXpedia’s established expertise since 2016, we have developed extensive experience in high-throughput proteomic technologies, including Olink’s proximity extension assay (PEA) platform. Our team has successfully conducted numerous Olink-based studies, focusing on identifying and quantifying modulated proteins in various biological samples, such as plasma. We are proficient in generating high-quality NPX data, including NGS-based outputs, and are equipped to manage complex projects from study design through to data analysis and reporting. At Biotest Facility, we handle various types of extractions, including RNA, DNA, and protein, from diverse sample types such as tissue, blood, cell-free specimens, and FFPE. Whenever possible, we utilise automated pipetting and perform quality control on all samples prior to analysis. Biotest Facility does also offer a number of down-stream analyses such as small molecule LC-MS services for precise analysis of various sample types. With our liquid chromatography-mass spectrometry (LC-MS) platform, we specialize in conducting pharmacokinetic and pharmacodynamic studies in rats and mice. Our expertise includes analysing tissues and biofluids, providing valuable insights into drug absorption, distribution, metabolism, and elimination. On the DNA level, we specialize in SNP genotyping using the Fluidigm system, which enables high-throughput analysis with low sample requirements. We also offer unrivalled precision and sensitivity using digital PCR (dPCR). By partitioning samples into individual sub-nanolitre volume reactions and counting positive and negative reactions, we can do rare mutation detection, assess gene expression, determine copy number. For gene expression analyses, we offer NanoString nCounter gene expression panels that focus on disease-related genes. This technology relies on the hybridization of target-specific probes without the need for enzymes. Alternatively, gene expression analysis can also be performed on the Fluidigm system or QuantStudio, allowing flexibility in the number of assays or samples.