7505 Fannin St Houston, TX, 77054 1913 United StatesBiostate: Cost-Effective RNA & Exome Sequencing at Scale Biostate is a multi-omics and artificial intelligence company specializing in high-throughput RNA Sequencing and next-generation Exome Sequencing to power discovery, translational research, and precision medicine. Built on patented wetlab chemistries (BIRT, PERD, MARE) and a global wetlab footprint, Biostate AI delivers large-scale, high-fidelity transcriptomic and genomic data at substantially reduced cost, enabling projects that were previously not feasible in terms of budget or scale. Our flagship Total RNA Sequencing service comprehensively captures both coding and non-coding RNA species, including lncRNA, miRNA, circRNA and enhancer RNA, going beyond traditional gene expression profiling that focuses only on mRNA. This chemistry is tightly integrated with Biostate’s AI platforms (OmicsWeb Copilot), providing end-to-end workflows from library prep and sequencing through interactive, AI-assisted bioinformatics for biomarker discovery, mechanism-of-action studies, drug response prediction, and disease stratification. In 2025, Biostate expanded its platform to Whole Exome Sequencing (WES), leveraging the same proven wetlab and automation stack that has delivered tens of thousands of RNA-seq libraries. The WES service is designed for research groups that need robust variant detection in coding regions, with >95% coverage at 30× (average ~100×), excellent performance on FFPE, dried blood spots, and other challenging or low-input DNA samples (≥10 ng), and seamless integration into K-Dense for AI-driven variant interpretation and cohort-level analyses. Key Services: Total RNA Sequencing - Whole-transcriptome profiling of coding and non-coding RNA - Suitable for discovery, mechanism-of-action, and AI model training RNA Sequencing (RNA-seq) / Gene Expression Analysis - Bulk RNA-seq for differential expression, pathway analysis, and longitudinal studies - Resequencing of existing cohorts to harmonize data for AI/ML pipelines Exome Sequencing / Whole Exome Sequencing (WES) - High-depth coding region interrogation for germline or somatic variant discovery - Optimized for challenging samples (FFPE, low-input, dried blood spots) Capabilities & Advantages: - Integrated omics + AI stack: sequencing, QC, and AI-driven analysis (OmicsWeb Copilot) - Patented chemistries enabling cost-efficient, large-scale RNA Sequencing and Exome Sequencing - Support for human and major preclinical species - Flexible project structures: pilot studies, grant-supported academic projects, and pharma-scale cohorts - Dedicated scientific support for study design, bioinformatics, and downstream interpretation