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31145 San Antonio St Hayward, CA, 94544 7977 United StatesAqtual's Biospecimen Offering: Aqtual, Inc. (Hayward, CA) is a precision medicine company developing products across indications on a proprietary active chromatin cell-free DNA (cfDNAac) platform. Built for immune-mediated disease rather than tumor genotyping alone, the platform requires deeply characterized patient material, so Aqtual acquires IRB-approved biospecimens across autoimmune, inflammatory, fibrotic, neurologic, and oncology indications. Partners can acquire specimens alone, specimens with matched cfDNAac data, or commission prospective collection with profiling built into the protocol. cfDNAac data generation may require an additional SOW through Scientist.com's biomarker service contract. Available Sample Types & Conditions: Consented, IRB-approved, protocol-driven collections with clinical annotation covering demographics, diagnosis and duration, disease activity scores, serology, current and prior therapy, and treatment response. Longitudinal and treatment-paired timepoints available. Banked and prospective material available. Sample Types Provided: Whole Blood Serum Plasma Tissue Synovial Fluid PBMCs CSF Preparation Methods: Fresh Frozen FFPE PBMCs Available Conditions: - Rheumatology and Autoimmune Rheumatoid Arthritis (RA), seropositive and seronegative Psoriatic Arthritis (PsA) Axial Spondyloarthritis Ankylosing Spondylitis Systemic Lupus Erythematosus (SLE) Lupus Nephritis Sjögren's Disease Systemic Sclerosis (Scleroderma), diffuse and limited cutaneous Juvenile Idiopathic Arthritis (JIA) Undifferentiated Inflammatory Arthritis Early Inflammatory Arthritis Polymyalgia Rheumatica Giant Cell Arteritis ANCA-Associated Vasculitis Behçet's Disease Idiopathic Inflammatory Myopathies (Dermatomyositis, Polymyositis) Antiphospholipid Syndrome Mixed Connective Tissue Disease Osteoarthritis (OA) Gout and Calcium Pyrophosphate Deposition Disease - Fibrotic Disease Idiopathic Pulmonary Fibrosis (IPF) Progressive Pulmonary Fibrosis Interstitial Lung Disease (ILD) RA-Associated ILD (RA-ILD) Connective Tissue Disease Associated ILD (CTD-ILD) Systemic Sclerosis Associated ILD (SSc-ILD) Hypersensitivity Pneumonitis Liver Fibrosis and Cirrhosis MASH and MASLD (NASH, NAFLD) Primary Biliary Cholangitis Primary Sclerosing Cholangitis Chronic Kidney Disease and Renal Fibrosis Diabetic Nephropathy Cardiac Fibrosis Crohn's Stricturing Disease (intestinal fibrosis) Keloid and Cutaneous Fibrosis - Respiratory Asthma Chronic Obstructive Pulmonary Disease (COPD) Chronic Bronchitis and Emphysema Sarcoidosis Bronchiectasis Chronic Rhinosinusitis with Nasal Polyps Acute Respiratory Infection and Post-Viral Lung Injury - Gastroenterology Inflammatory Bowel Disease (IBD) Crohn's Disease Ulcerative Colitis Celiac Disease Eosinophilic Esophagitis - Dermatology Plaque Psoriasis Hidradenitis Suppurativa (HS) Atopic Dermatitis Vitiligo Alopecia Areata - Oncology Non-Small Cell Lung Cancer (NSCLC) Small Cell Lung Cancer (SCLC) Breast Cancer, including HR positive, HER2 positive, and triple negative Colorectal Cancer Pancreatic Cancer Gastric and Esophageal Cancer Hepatocellular Carcinoma Prostate Cancer Bladder and Urothelial Cancer Renal Cell Carcinoma Ovarian Cancer Endometrial Cancer Head and Neck Squamous Cell Carcinoma Melanoma Glioblastoma and Glioma Thyroid Cancer Sarcoma Non-Hodgkin Lymphoma Hodgkin Lymphoma Multiple Myeloma Chronic Lymphocytic Leukemia Acute Myeloid Leukemia Myelodysplastic Syndromes Immunotherapy-treated cohorts (checkpoint inhibitor responders and non-responders) Immune-Related Adverse Events (irAE) cohorts - Neurology Multiple Sclerosis (MS), relapsing remitting Multiple Sclerosis, secondary progressive Multiple Sclerosis, primary progressive Clinically Isolated Syndrome and Radiologically Isolated Syndrome Neuromyelitis Optica Spectrum Disorder (NMOSD) MOG Antibody Associated Disease (MOGAD) Autoimmune Encephalitis Myasthenia Gravis Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Guillain Barré Syndrome Alzheimer's Disease Mild Cognitive Impairment Parkinson's Disease Lewy Body Dementia Frontotemporal Dementia Amyotrophic Lateral Sclerosis (ALS) Huntington's Disease Progressive Supranuclear Palsy Multiple System Atrophy Traumatic Brain Injury and Chronic Traumatic Encephalopathy Stroke and Post-Stroke Recovery Epilepsy Migraine Peripheral Neuropathy, including diabetic and chemotherapy induced Neuroinflammation cohorts - Endocrine and Metabolic Type 1 Diabetes Type 2 Diabetes Autoimmune Thyroid Disease (Hashimoto's Thyroiditis, Graves' Disease) - Controls Matched healthy control donors, age, sex, and site matched
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