521 Cottonwood Dr. Ste. 111 Milpitas, CA, 95035 United StatesAdvancing Gene and Cell Product Development Through iPSC and Genome Editing Technologies Applied StemCell strives to advance gene-editing and stem cell innovation for biomedical research and the biotechnology industry to assist in the development of breakthrough therapeutic approaches to cure intractable diseases. 1. GMP iPSCs / MSCs Cell Manufacturing • GMP iPSC Services & Products --- Reprogramming, Genome Editing, & Differentiation/cGMP Grade iPSC Control Line Available • GMP MSC Purification, Expansion and Banking • iPSC-TARGATT™-CAR-NK Differentiation --- Knock in your CAR gene into our control iPSCs and differentiate into NK or T Cells 1. iPSCs, Stem Cell Research Services & Products: • iPSC Generation & Characterization • iPSC Genome Editing (CRISPR & TARGATT™) --- Off-the-shelf iPSC-genome edited products are available for purchase • iPSC Differentiation, including T Cells, NK Cells, HPCs, Monocytes, RPEs, Photoreceptors, Endothelial Cells, Oligodendrocytes, NPC, Neurons, Astrocytes, DOPA, Microglia, Cardiomyocytes, and Skeletal Muscle) --- Control iPSC-derived items are available • Disease Modeling and Drug Toxicity Screening (BBB testing), Cytotoxicity Testing • Available “Master” control iPSCs that have proven genome-editing/differentiation capabilities. Currently, it is being used as a benchmark material for the development of measurements and standards for rapidly evolving genetically engineered cells used in cell therapy research. 2. Animal Model Development Service: • PBMC and CD34 Mouse Models (Pre-screened, pre-injected) • Mouse Models and Rat Models • Site-specific Knock-in Mouse Service (< 22kb) – TARGATT™ • Mouse Repository of 2000+, includes 50+ humanized mouse models and Cre. • New COVID-19 Humanized Mouse Models • In Vivo Antibody/Drug Candidate Testing 3. Antibody Discovery & Bioproduction: • Antibody Discovery: TARGATT™ Cell-Based Antibody Library (HEK293/CHO), TARGATT™ Master Cell Line HEK293 & Rabbit Monoclonal Antibody Development • Bioproduction: Bioproduction (CHO) & Transgenic Animals-Rabbit 4. Tissue Samples & Primary Cells • Human Primary Cells: PBMCs, CD34+ & More/PBMC • Human Hematologic Tissue Products: WB procurement • Human Diseased Products • Non-Human Primate Cells & Hematologic Tissue Products • Custom FFPE Service (block/slide/scroll) – Cell Pellet and Tissue • FFPE Products – Human & Animal Cell Pellets, Human & Animal Tissues • Cytokines & Growth Factors • Custom Primary Cell Isolation Service • Tissue Collection 5. CRO/Research Cell and Gene Therapy Bioservices • Cell-Based Assay: CAR-NK and CAR-T Assays, AAV, Potency assays, IND-Enabling Studies, Cellular Viability & Proliferation, Migration Studies & ELISA/ELISpot • In Vivo/Mouse Assay Services: Efficacy Service with HU Models, Dose-Ranging & Biodistribution • TARGATT™ Knock-in Cell Line • Lentivirus Stable Cell Line Generation • Immortalization Services • Cell Line Irradiation Service • Virus Packaging • CMC Support • HLA typing Take advantage of our proprietary TARGATT™ gene knock-in technology and HEK293/CHO-K1 systems for high-efficiency knock-in of large transgenes at safe harbor loci (600x times*) to generate your own library for antibody discovery/screening.
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We believe that every researcher across the world should be able to connect with the thousands of global CROs that exist and have the opportunity to work together. Like many industries,the life science supply chain has been disrupted over the last year. But there are many other circumstances such as international customs regulations or sensitive shipping times that create limitations around which countries are feasible to partner with. Sometimes, finding a CRO based in a country that best suits your research needs is imperative. We hope this contract research map allows you to find the right partner in the right place at the right time.
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