27 McCullough Dr. New Castle, DE, 19720 United StatesDeep expertise in complex chemistry: Advanced small molecule programs including heterocycles, high purity monomers, deuterated and isotopically labeled compounds, metabolites, regulated/key starting materials, and complex intermediates, as well as emerging modalities such as PROTACs, peptides, oligonucleotides, ADC linkers, and specialty materials Deep scientific bench strength and high scientific rigor: 150+ chemists in house, with over 80% holding PhDs, experienced in solving highly challenging synthetic and scale up problems. Our team ensures deep understanding of chemical nuance and consistently high quality deliverables U.S.-based Chemistry CRO & CDMO: headquartered in Delaware, with a strong reputation for quality, reliability, and scientific rigor across pharma, biotech, and medical device applications with 35+ years of experience supporting drug discovery, development, and commercialization of novel chemistries Faster, lower risk development: Robust, scalable synthetic routes designed early to accelerate SAR cycles and minimize downstream scale up risk. Integrated delivery model: Discovery, process development, and specialty manufacturing handled by unified scientific teams—reducing handoffs and improving first time right quality. Seamless scale up: Efficient progression from milligram quantities to multi kilogram production. Proven speed and reliability: Trusted for time critical programs requiring rapid turnaround without compromising quality Problem solving partner: Frequently selected when other providers cannot deliver viable synthetic solutions Flexible engagement models: Support available through both FTE and fee for service structures based on project needs -Comprehensive small‑molecule synthesis capabilities, including: Heterocyclic compounds containing Nitrogen, Oxygen and Sulfur High‑purity monomers Deuterated compounds Stable‑isotope labeled compounds (^2H, ^13C, ^15N) Natural products Impurities and reference standards Metabolite synthesis (hydrolysis, oxidation, glucuronides, etc.) Protacs Broad experience with diverse ligase binders ((hetero)aryl-glutarimides, thalidomides, and (hetero)aryl-dihydrouracils) Proficient in PEG-amino amide/rigid/flexible linkers Optimized conjugation for multiple chemotypes: amides, O-/N-alkylation, C–C bonds, and sulfonamides Peptides and oligonucleotides (linear and cyclic using solid and liquid phase synthesis) Linker chemistry for ADC's Peptide-drug conjugate Analytical services like method development Stability studies Polymorph and salt screen Regulated starting materials (RSM) Key starting materials (KSM) Amino Acids, Chiral Chemistry-Catalysis, Asymmetric Synthesis, Diastereomeric Salt Crystallization, Enzymatic Resolutions, Diels-Alder, Distillation, Energetic Chemistries, Halogenation, Chloromethylation, Hydrogenation, Low Temperature/Commercial Scale, Nucleosides and Sugars, Organometallic Chemistry – Grignard, Alkylithiums, Ullman, Oxidation (Classical, TEMPO/NaOCl, Pyr-SO3), Palladium and Nickel Catalyzed – Heck, Suzuki and related, Steroids , Sulfonation, Thiophosgenation, Phosgenation, High Containment/Cytotoxic Capabilities upto OEB 4,