Shinjuku Sumitomo Building, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0227, JapanAC Medical provides one-stop solutions for your clinical development projects by combining a full spectrum of services, including monitoring, electrical data capture (EDC), data management, and statistical analysis. We are a Contract Research Organization (CRO) with a competitive edge in IT, offering efficient yet high-quality services.

1-3-25 Koishikawa, Bunkyou-ku Koishikawa Daikoku Bldg. 6, 7F Tokyo 112-0002 JapanAcronet offers toxicology, safety pharmacology studies, virus validation, ADME, and phase I clinical trials.

2-21 東ビル7F 揚場町 新宿区, 東京都, 162-00824 JapanActive Motif, Inc. is a biotechnology company, founded in 1999. The Company develops cell and molecular biology-based research tools that assist with determining the functions, interactions, and regulation of proteins. Active Motif serves the medical research industry worldwide. Active Motif, is the leader in epigenetic services, including a diverse range of assays such as ATAC-seq, ChIP-Seq FactorPath, ChIP-Seq HistonePath, ChIP-Seq TranscriptionPath, ChIP-Seq Tissue, MeDIP-Seq, hMeDIP-Seq, RNA-seq, RRBS, CUT&Tag (cells & Tissue), Hi-C and ChIP antibody validation. Active Motif also offers the latest epigenetic mass spectrometry services for co-factor identification (RIME) and histone modifications (Mod Spec). Active Motif also has expertise in developing custom B-cell antibodies for epigenetic marks and factors. In addition, Active Motif provides the latest single cell assay services in conjunction with 10x Genomics technologies, such as 3' scRNASeq, scATACSeq, 10X Multiome and TotalSeq. Active Motif is able to provide all services at scale to address the needs of the pharmaceutical research markets.

2-26-1 Muraoka-Higashi Kanagawa, Kanagawa, 2510012 JapanWe provide downstream analytics, developability, and pharmacology assessments to help scientists rapidly evaluate, rank, and de-risk antibody candidates, with integrated support across a broad range of biologic modalities. Alloy services on Scientist.com are available à la carte and can be combined into tailored workflows spanning discovery, optimization, and preclinical decision-making, depending on program needs. Alloy Therapeutics is a biotechnology ecosystem company accelerating drug discovery and development through AI-powered platforms and scientific expertise. Alloy provides access to technologies, services, and company-creation capabilities across biologic modalities, including antibodies, bispecifics, TCRs, genetic medicines, cell therapies, and drug delivery, supported by integrated analytics, developability platforms, and in vitro and in vivo pharmacology to help reduce the time and cost to advance programs from discovery to human data.

Jowa Takanawa Building 8F 1-5-4 Takanawa, Minato-Ku 108-0074 Tokyo - JapanAlpha MOS provides chemical analysis, odor monitoring solutions, and electronic noses, tongue, and eyes.

Central Chemicals Co, Inc. Ishida Bldg, 4 Chome 2-17, Nihonbashi-hongokucho, Chuo-ku, Tokyo 103-0021, JapanApollo Scientific is proud to be your socially responsible supplier of choice, holding a Platinum EcoVadis rating and ranking in the top 1% globally for corporate social responsibility within our industry. Since 1993, we have been committed to delivering high-quality chemicals and advanced materials to support scientific research across diverse fields, including pharmaceuticals, chemistry, and biotechnology. Our dedication to sustainability is reflected in every aspect of our operations, from sourcing and manufacturing to product delivery. We adhere to rigorous quality control standards, ensuring our chemicals, reagents, and custom synthesis services meet the demanding requirements of researchers worldwide. With a focus on both environmental and social responsibility, Apollo Scientific is a trusted partner in advancing scientific discovery, offering rare chemicals, laboratory supplies, and innovative solutions designed to propel scientific progress.

Healthcare Materials Division 1-1-2 Yurakucho Chiyoda-ku, Tokyo, 100-0006 JapanAsahi Kasei Corporation (Headquarters: Tokyo, Japan) is a leading manufacturer and supplier of functional pharmaceutical excipients in Japan, including microcrystalline cellulose. To address the growing demand for advanced formulation research, we are currently engaged in the business development of a next‑generation pharmaceutical excipient for injectable formulations: Sonanos™, a hyaluronic acid nanogel. Sonanos™ can function as an API carrier, enabling its use as a sustained release agent for biologics or as a solubilizer for higher-molecular-weight modalities.

1-1-1-808 Eifuku, Suginami, Tokyo 168-0064 JAPANAsinex provides chemical library design, compound resupply, along with hit expansion and lead optimization services.

2nd Mantomi Building, 6th Floor 1-14-4 Kameido, Koto-ku, Tokyo JAPAN 136-0071ATDBio founded in 2005 by Prof. Tom Brown, a leading nucleic acid chemist, is now a part of Biotage. We are experts in oligonucleotide synthesis for therapeutic applications: ASOs, siRNA, RNAi, Aptamers, new chemical modalities.

26-1, Muraoka-Higashi 2-chome Fujisawa, Kanagawa, 2510012 JapanAxcelead Drug Discovery Partners is the premium CRO in Japan, a spin-out company from Takeda Pharmaceuticals, and provides pharma-standard drug discovery services as your drug discovery engine. Scope of Business: ・Drug discovery services Capability: ・Screening : Assay development, HTS, Hit finding, Compound management, Phenotypic screening, AS-MS ・Chemistry: Medicinal Chemistry, Peptide chemistry, Synthetic chemistry, High-throughput synthesis, Analytical chemistry, Computational chemistry, RNA-Targeting Small Molecules, Targeted Protein Degradation ・Biology: oncology, immunology, neuroscience, cardiovascular and metabolism, gastrointestinal motility, cell therapy using large animals, Omics, Bioinformatics, Genetically modified animals, Histopathology, Spatial Transcriptomics, Single cell RNA-seq, Single nucleus RNA-seq ・DMPK: ADME screening, Discovery DMPK studies, Physicochemistry and preformulation, studies ・Safety: In vitro and in vivo exploratory safety studies ・IND/NDA enabling studies ・Target validation/Efficacy studies ・Lead generation/optimization

Fujisawa, Kanagawa Prefecture, 251-0012 JapanAxcelead Drug Discovery Partners is the premium CRO in Japan, a spin-out company from Takeda Pharmaceuticals, and provides pharma-standard drug discovery services as your drug discovery engine. Scope of Business: ・Drug discovery services Capability: ・Screening : Assay development, HTS, Hit finding, Compound management, Phenotypic screening, AS-MS ・Chemistry: Medicinal Chemistry, Peptide chemistry, Synthetic chemistry, High-throughput synthesis, Analytical chemistry, Computational chemistry, RNA-Targeting Small Molecules, Targeted Protein Degradation ・Biology: oncology, immunology, neuroscience, cardiovascular and metabolism, gastrointestinal motility, cell therapy using large animals, Omics, Bioinformatics, Genetically modified animals, Histopathology, Spatial Transcriptomics, Single cell RNA-seq, Single nucleus RNA-seq ・DMPK: ADME screening, Discovery DMPK studies, Physicochemistry and preformulation, studies ・Safety: In vitro and in vivo exploratory safety studies ・IND/NDA enabling studies ・Target validation/Efficacy studies ・Lead generation/optimization

B-Bridge Co., Ltd. Shoji Building 7F 3-4-10 Misakicho Chiyoda-ku, Tokyo 101-0061 JapanB-Bridge International offers kits, reagents, and products related to: adipocytes, antibodies, cell strain, cloning, culture medium, ELISA, hydrogels, stem cells, and nucleic acid purification.

4-7-3-101 Ebara, Shinagawa-ku Tokyo 142-0063 JapanBIOBASE Biological Databases offers data collection and analysis, gene expression analysis, pathway modeling, and biological databases.

8F, SB bldg., 1-4-6, Nezu, Bunkyo-ku, Tokyo 113-0031, JapanBioLegend strives to provide quality research reagents and expert technical support to the scientific community worldwide. We look forward to serving your research needs and becoming your long term research partner.

Shinkawa KS Building 3F, 2-22-6 ShinkawaCuo-ku, 104-0033 Tokyo, JapanBiologics Consulting Group, Inc. (BCG) provides regulatory and product development advice on production of biological, drug and device products.

105 Higashifukai, Nagareyama City, Chiba 270-0101 JapanBio Matrix Research provides custom base sequencing, DNA microarray analysis, and systematic generation of monoclonal antibodies.

Chiyoda-ku, Tokyo, JapanBioView offers MRI imaging, research support, and nondestructive testing of materials.

#415 Research Innovation Center, Bldg. 121, Waseda University, 513 Wasedatsurumakicho Shinjuku-ku, Tokyo, Not Applicable, 162-0041 JapanbitBiome is a biotech company with microbial single-cell genome analysis technology and microbial genome database.

Setagaya-ku, Tokyo, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Kannami-cho, Tagata-gun, Shizuoka, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Tsukuba-shi, Ibaraki, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

36-7 Oyama-cho, Shibuya-ku, Tokyo 151-0065, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

36-7 Oyama-cho Shibuya-ku, Tokyo, 151-0065 JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

Saitama, Saitama Prefecture JapanBushu Pharmaceuticals offers product lifecycle management, drug delivery, manufacturing, packaging, and quality control.

Tokyo, JapanCactus Life Sciences provides cutting-edge solutions for medical affairs, powered by strategic insights and digital enhancements grounded in science. 1. Scientific Publications 2. Medical Communications 3. Medical Information 4. Medical Device Solutions 5. HEOR 6. Digital and Technology solutions 7. Patient centric services

AMETEK Co., Ltd. CAMECA B.U. Tokyo office: 3F, Shiba NBF Tower 1-1-30, Shiba Daimon, Minato-ku, Tokyo 105-0012, Japan

Marunouchi Kitaguchi Building 9F 1-6-5 Marunouchi Chiyoda-ku, Tokyo, 100-005 JapanCaris Life Sciences offers molecular profiling (WES/WTS), clinical trial enrollment, and IVD/CDx development services.

Yokohama, JapanCellaVision offers analyzers, review software, competency software, and blood smearing devices.

Yokohama Bio Industry Center 1-6 Suehiro-cho, Tsurumi-ku Yokohama, Kanagawa, 230-0045 JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

75-1, Ono-cho, Leading Venture Plaza 201 Tsurumi-ku, Yokohama 230-0046 JapanIt is our goal to make proteins work! CellFree Sciences is using its own wheat germ cell-free protein expression system to serve protein needs in life sciences and for industrial use. Performing protein synthesis outside of the cell in an in vitro system allows us to separate protein production from other processes required to maintain a cell. Thus, working cell-free opens new opportunities to better adopt protein synthesis to protein needs offering dedicated reagents to make for example membrane proteins in a lipid environment, labeled proteins for use in MS or NMR, or well-folded antigens for antibody production. Our scalable and flexible expression system can serve protein needs from the small amounts used for production of our protein bead arrays presenting up to 23,000 human full-length proteins to individual proteins made on large-scale for use in structural biology, medical research, on-demand product production, and diagnostic tests. Our eukaryotic expression system has a strong record on supporting a wide range of projects working on all kinds of proteins from the kingdoms of life.

113-0033 2-9-7 Hongo, Bunkyo-ku, Tokyo JapanCellSeed provides safe and advanced tissue-engineering products.

Tokyo, JapanCTL offers products and services for immune assays. These include a library of cryopreserved human PBMC with HLA-typed donors that have established T cell reactivity. We specialize in immune characterization through ELISPOT, providing ImmunoSpot analyzers, ImmunoSpot kits, hands-on wetlab training, consultation, and GLP contract research.

Tokyo, Tokyo JapanChiome Bioscience provides monoclonal antibody products and antibody design.

Tokyo, JapanChiome Bioscience provides monoclonal antibody products and antibody design.

1-1 Nihonbashi-Muromachi 2-Chome Chuo-ku Tokyo, 103-8324 JapanThe Chugai Group upholds its mission statement—which consists of its mission, its core values and its envisioned future—in order to be a business that meets a diverse array of stakeholder expectations as it realizes its corporate responsibility to society. It is on the basis of this mission statement that the Chugai Group conducts its business operations. Mission Statement Mission Chugai's mission is to dedicate itself to adding exceptional value through the creation of innovative medical products and services for the benefit of the medical community and human health around the world. Core values The primary focus of all our activities is patients and consumers. In all our activities we are committed to the highest ethical and moral standards. We value employees who develop profound expertise and broad perspectives and pursue innovation and challenges without fear of failure. Wherever we operate around the world we seek to understand and respect people and cultures and to behave as good corporate citizens. We promote an open and active corporate culture that respects individuality, ability and teamwork. We care about the global environment. We aim to achieve a fair return for our shareholders and to disclose information appropriately and in a timely manner. Envisioned Future As a most important member of the Roche group, we aim to become a top Japanese pharmaceutical company by providing a continuous flow of innovative new medicines domestically and internationally.

1-1 Nihonbashi-Muromachi 2-Chome Chuo-ku, Tokyo 103-8324 JAPANThe Chugai Group upholds its mission statement—which consists of its mission, its core values and its envisioned future—in order to be a business that meets a diverse array of stakeholder expectations as it realizes its corporate responsibility to society. It is on the basis of this mission statement that the Chugai Group conducts its business operations. Mission Statement Mission Chugai's mission is to dedicate itself to adding exceptional value through the creation of innovative medical products and services for the benefit of the medical community and human health around the world. Core values The primary focus of all our activities is patients and consumers. In all our activities we are committed to the highest ethical and moral standards. We value employees who develop profound expertise and broad perspectives and pursue innovation and challenges without fear of failure. Wherever we operate around the world we seek to understand and respect people and cultures and to behave as good corporate citizens. We promote an open and active corporate culture that respects individuality, ability and teamwork. We care about the global environment. We aim to achieve a fair return for our shareholders and to disclose information appropriately and in a timely manner. Envisioned Future As a most important member of the Roche group, we aim to become a top Japanese pharmaceutical company by providing a continuous flow of innovative new medicines domestically and internationally.

5-2-20 Akasaka, Minato-ku Akasaka Park Bldg, 18F Tokyo, Tokyo, 1076118 JapanClarivate is a leading global provider of transformative intelligence, including Cortellis and Decision Resources Group ("DRG"). We offer enriched data, insights & analytics, workflow solutions and expert services in the areas of Academia & Government, Intellectual Property and Life Sciences & Healthcare. For more information, please visit clarivate.com

Kamikiyoto Kiyose-shi, Tōkyō-to, 204-0013 Japan

1-10-1 Kamikiyoto Kiyoseshi, Tokyo, 2040013 Japan

Level 7, Wakamatsu Blg, 3-3-6 Nihonbashi, Hon-cho Cho-ku, Tokyo, 103-0023 JapanConfocal Science provides protein crystallography.

Toyo Ekimae Building 2-20, Toyo2-chome koto-ku, Tokyo, 135-0016 JapanCosmo Bio provides unique services and quality life science products from leading Japanese manufacturers, to laboratories, research institutes, life-science education and testing organizations. We take pride in that our products fill a current need for hard to find reagents and instruments, while being created under the meticulous care of Japanese scientists and researchers. By maximizing our distribution ability and cooperative effort with our headquarters in Tokyo, we uphold the commitment and responsibility befitting that of a company trusted by its valued customers. Custom Drug Discovery Services From Japan https://www.cosmobio.co.jp/c/custom-drug-discovery-services/index.asp

Tokyo, JapanCosmo Bio provides unique services and quality life science products from leading Japanese manufacturers, to laboratories, research institutes, life-science education and testing organizations. We take pride in that our products fill a current need for hard to find reagents and instruments, while being created under the meticulous care of Japanese scientists and researchers. By maximizing our distribution ability and cooperative effort with our headquarters in Tokyo, we uphold the commitment and responsibility befitting that of a company trusted by its valued customers. Custom Drug Discovery Services From Japan https://www.cosmobio.co.jp/c/custom-drug-discovery-services/index.asp

1-13-23 Minami-Ikebukuro Toshima, Tokyo, 171-0022 JapanCROee has over 10 years of experience with patient recruitment in Japan, supporting Phase I to Phase IV studies, as well as other clinical trials. In fact, we enrol more than 20% of patients in studies performed in Japan. Further, CROee’s marketing team are healthcare marketing specialists who take advantage of the 800,000 personal healthcare records in our volunteer database to analyze the patient experience of each targeted disease and provide the optimal solution for our clients. By utilizing our patient database of over 800,000 members, we can bring the best solution of DTC marketing based on patient insights and patient experiences. We can also create an ideal patient experience from trial studies to improve our marketing strategies.

YS Building 2F, 1-13-23 Minami-Ikebukuro, Toshima-Ku TOKYO, Tokyo, 1710022 JapanCROee has over 10 years of experience with patient recruitment in Japan, supporting Phase I to Phase IV studies, as well as other clinical trials. In fact, we enrol more than 20% of patients in studies performed in Japan. Further, CROee’s marketing team are healthcare marketing specialists who take advantage of the 800,000 personal healthcare records in our volunteer database to analyze the patient experience of each targeted disease and provide the optimal solution for our clients. By utilizing our patient database of over 800,000 members, we can bring the best solution of DTC marketing based on patient insights and patient experiences. We can also create an ideal patient experience from trial studies to improve our marketing strategies.

2-11-8 Shibadaimon Tokyo, Tokyo, 1050012 JapanCrown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) dedicated to accelerating drug discovery and development in oncology and immuno-oncology. We partner with biotech and pharmaceutical companies to provide innovative, tailored solutions spanning preclinical research, translational platforms, and clinical trial support. With the world’s largest commercially available patient-derived xenograft (PDX) collection and approximately 1,000 tumor organoid models powered by Hubrecht Organoid Technology, we offer unparalleled insights across 35 cancer indications. Our expertise spans in vivo, in vitro, ex vivo, and in silico methods, complemented by advanced laboratory services that span the entire drug development continuum. Additionally, our extensive biobank of liquid and human biospecimens, complete with clinical histories, enhances oncology research capabilities. Operating from 11 state-of-the-art facilities across the US, Europe, and APAC, our laboratories meet the highest industry standards, including accreditation by the College of American Pathologists (CAP) and the International Organization for Standardization (ISO). To learn more, visit www.crownbio.com.

University of Tokyo Entrepreneur Plaza 701,7-3-1 Hongo Bunkyo, Tokyo, 113-0033 JapanWe are a biotech company that originated from the University of Tokyo, supporting the preclinical phase of drug discovery using biotechnology and digital technologies, including 3D imaging technology CUBIC and next-generation epitope mapping service DECODE. With CUBIC technology, we can quantitatively analyze the pharmacokinetics and efficacy verification in three dimensions. Furthermore, using DECODE, we can identify the specificity of epitopes recognized by antibodies at the highest global standard. By utilizing our services, we enable the reduction of the drug discovery timeline.

ICN Building 5A 2-27-17 Hongo, Bunkyo-ku, Tokyo, 113-0033, JAPANWe contribute to significant advances in medical treatments through our revolutionary 3D tissue-engineering technology. Because our society faces an aging population and increasing prevalence of chronic diseases, regenerative medicine will play a growing and important role in patient care, particularly where satisfaction is low with medical treatments using traditional drugs, devices, and surgery. In addition to cell quality, the performance of cellular products relies on their composition. The conventional approach of injecting cell suspension has proved unsuitable for regenerating solid tissue because it does not introduce sufficient cell numbers while scaffolding, such as with animal-derived collagen, raises safety concerns related to allergies and viral vectors. With our proprietary tissue-engineering technologies, cellular aggregates are assembled into three-dimensional macrostructures without the need for scaffolding materials. The subsequent self-organization/maturation process in our customized bioreactor generates functional tissues/organs. To promote our platform technologies, we successfully developed the BIO 3D PRINTER, Regenova®. Regenova® is a state-of-the-art robotic system that enables fully automated fabrication of three-dimensional artificial tissues/organs from living cells.

2-18-1, Konan Minato-ku, Tokyo 108-8230, JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

Mita Knox Bldg. 3F/4F, 5-16-14 Shiba Minato-ku, Tokyo, 1080014 Japan

Room 108, Leading Venture Plaza-2, 75-1, Ono-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0046 JapanDNAFORM offers cDNA libraries, high throughput DNA preparation, and gene expression services.

ASK Sanshin bld. 3F 2-6-29, TurumiChuo, Tsurumi Yokohama, Kanagawa, 230-0051 JapanDNAFORM offers cDNA libraries, high throughput DNA preparation, and gene expression services.

Yoshimi-machi Yoshimi, Saitama Prefecture, 355-0166 Japan

31-8, 1-Chome, Takadanobaba Shinjuku-ku, Tokyo, 169-0075 Japan

Higashimatsuyama, Saitama Prefecture, 355-0071 Japan

3F, Aobadai 4-7-7, Meguro-ku Tokyo 153-0042 JapanEffector Cell Institute provides cell-based drug discovery, regenerative medicine, and assays.

Sunrise Mita Bldg. 6F, 3-16-12, Shiba, Minato-ku, Tokyo, 105-0014, JapanThomas Emery (Snr) started a tallow and candle business in 1840. A decade later, The Emery Candle Company offered customers sturdier, whiter, dripless candles made of stearic acid. Soon, the expanded product line also included elaine oil (oleic acid) and sweetwater (glycerine). By 1872, the company was involved in fatty acid exploration while growing an existing product line that included elaine oil (oleic acid) and sweetwater (glycerine). Click here to find more. Today, 174 years later, Emery Oleochemicals is a name synonymous with the production of high quality, natural-based chemicals commonly made from natural oils and fats. Our business is increasingly focused in high-value derivatives. Through our six dedicated business units , we have the ability to provide you with customisable, high-performance, market-based solutions. Backed by an extensive distribution network covering over 50 countries globally, Emery Oleochemicals applies its philosophy, Creating Value with our wide-ranging product portfolio for use in the home and personal care, construction, automotive, lubricants, packaging, food and beverage, pharmaceuticals, textiles, electrical and electronics, furniture and bedding, and agriculture industries. Headquartered in Shah Alam, Malaysia,our manufacturing facilities and sales and marketing offices are located in Asia Pacific, Europe and North America. We are backed by a diverse workforce of more than 1,000 people and an extensive distribution network covering over 50 countries globally.

Tokyo, JapanEnBioTec Laboratories provides screening services, ELISA systems, and PCB detection.

7F, Sumitomo Bldg., Higashi Ikebukuro 1-10-1 Toshima-Ku, Tokyo 170-0013, JapanEurofins EAG Materials Science, LLC has a long history, dating back to the birth of the company in 1978 in California, as Charles Evans & Associates. Over the years we have expanded from a single location offering SIMS only to having over 200 employees offering over 30 different services via 14 locations in 8 different countries. The original focus of the company was supporting semiconductor manufacturing but now we also work with multiple further industries beyond semiconductors, including: solar/PV, lighting, photonics, energy storage, aerospace & defense, medical devices, raw materials, glass, polymers and plastics and consumer products. EAG's analytical expertise is what enables us to help our clients to meet their goals. Our on-demand analytical testing services can help streamline R&D, solve urgent problems during manufacturing and help resolve materials related issues in the global supply chain, both within and between organizations.

Hatano Research Institute, Food and Drug Safety Center 729-5 Ochiai Hadano, Kanagawa 257-8523 JapanFood and Drug Safety Center (FDSC) offers contract research services for safety and quality testing of compounds, materials, foods, drugs, medical devices, and chemical agents.

Hadano, Kanagawa Prefecture JapanFood and Drug Safety Center (FDSC) offers contract research services for safety and quality testing of compounds, materials, foods, drugs, medical devices, and chemical agents.

7-3, Akasaka 9-chome Minato-ku, Tokyo, 1070052 JapanFujifilm is committed to advancing human health through its diverse products and services. By leverages its extensive technologies and expertise, the company contributes to various aspects of health, spanning prevention to diagnosis and treatment. Fujifilm provides drug discovery services using cutting edge technologies developed through the Group's research & development in pharmaceuticals. ・Cyclic peptide screening using mRNA display technologies and Peptide synthesis ・in vitro assay services using hiPSC drived cells; Pharmacology, Safety, - Pharmacology study: neurodegenerative diseases, neuroinflammation diseases, cardiomyocyte - Safety: QT prolongation risk assessment of drug candidates using iPSC-derived cardiomyocyte - Permeability test of compounds using iPSC-derived intestinal epithelial cells or BBB ・Pharmacology study, drug discovery service of Infectious disease ・Medicinal Chemistry ・AI Drug Design https://global.fujifilm.com/en/healthcare-life-sciences/cro

577, Ushijima Kaisei-cho, Kanagawa, 2580022 JapanFujifilm is committed to advancing human health through its diverse products and services. By leverages its extensive technologies and expertise, the company contributes to various aspects of health, spanning prevention to diagnosis and treatment. Fujifilm provides drug discovery services using cutting edge technologies developed through the Group's research & development in pharmaceuticals. ・Cyclic peptide screening using mRNA display technologies and Peptide synthesis ・in vitro assay services using hiPSC drived cells; Pharmacology, Safety, - Pharmacology study: neurodegenerative diseases, neuroinflammation diseases, cardiomyocyte - Safety: QT prolongation risk assessment of drug candidates using iPSC-derived cardiomyocyte - Permeability test of compounds using iPSC-derived intestinal epithelial cells or BBB ・Pharmacology study, drug discovery service of Infectious disease ・Medicinal Chemistry ・AI Drug Design https://global.fujifilm.com/en/healthcare-life-sciences/cro

9-7 Hongo 2-Chome, Bunkyo-ku, Tokyo 113-0033 JAPANFunakoshi Co., Ltd. has contributed as a leader to distribute research reagents and instruments for researchers in the life science fields since its foundation. Our corporate mission is to provide products to broad range of customers throughout our worldwide network. We would like to take this opportunity to introduce selected products, which have been getting favorable response from our customers.

Tokyo, JapanGene Logic (a division of Ocimum Biosolutions) provides RNA and DNA isolation, qRT-PCR, genotyping, copy number analysis, microdissection and expression analysis services using ABI TaqMan or Agilent, Affymetrix, Ilumina and BioTrove platforms.

G-BASE tamachi, shiba 5-29-11 minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

shiba 5-29-11 G-BASE tamachi 2F minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

shiba 5-29-11 G-BASE tamachi 3F minato ku, Tokyo, 108-0014 JapanGenequest Research Genequest Inc. has a variety of ongoing genetic studies within our internal research team and with our collaborators at research universities or companies. "Genequest" = "Gene" + "quest" We are accelerating research with ongoing genetic studies to contribute to human health all over the world. Through a challenging large-scale research project with our partners, our quest is to maximize the synergistic effects between research institutes and personal genome services.

75-1 Ono-cho, Tsurumi-ku Yokohama, Kanagawa 230-0046 JapanGenoMembrane supplies transporter related products including ABC transporter membranes/vesicles and SLC transporter products.

3F Ishikawa EMC Laboratory Bldg. 2-3-18 Namamugi, Tsurumi-ku Yokohama, Kanagawa, 230-0052 JapanGenoMembrane supplies transporter related products including ABC transporter membranes/vesicles and SLC transporter products.

2-2 Kanda-Tsukasa-cho, Chiyoda-ku, Tokyo 101-0048 Japan Glycogene INC is an advanced biotechnology company founded in Wuhan, China with a site in Research Triangle Park, North Carolina. Our business spans from R&D all the way to the manufacturing stage to serve our customers in their evolving needs for high and consistent quality reagents. Here at Glycogene, using our chemo-enzymatic and fermentation techniques, our scientific experts are more than happy to offer our expert service with high quality and competitively priced products such as nucleosides, nucleotides, phosphoramidites and carbohydrates. We also provide custom synthesis services for unique structures designed by you.

1-3-3 Azamino-minami, Aoba-ku, Yokohama 225-0012, JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

Yokohama, JapanGP Biosciences offers microarray, glycan profiling, genotyping, and gene expression services.

Tokyo JapanHaploPharma develops technologies to discover genetic biomarkers for the prediction of individual drug response.

Diaya Yaesu Building 3F 2-2-1 Yaesu Chuo-ku, Tokyo 104-0028 JapanHaploPharma develops technologies to discover genetic biomarkers for the prediction of individual drug response.

Ibaraki, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

31-2, Kanda Higashi Matsushita-Cho Chiyoda-Ku, Tokyo, 101-0042 JapanWe, Hoshi Corporation, started our business as a raw material trading company in 1975. As well as making use of the strengths of this procurement capability, we also distribute ingredients of cosmetic and health supplements. It is possible for us to source all kinds of raw materials by building a relationship of trust and partnership with other local raw material trading companies. In recent years, we focus on “ocean-origin materials” which is highly evaluated by its effect-efficacy to skin. We offer a broad line of safe and secure ingredients such as Marine Chondroitin and Marine Placenta that has long been loved by Japanese women. Please feel free to contact us for any kinds of raw materials for cosmetics and health supplements – we are able to supply you a variety of them.

Tokyo, JapanHybrigenics Services is a complete service provider of cutting-edge technologies dedicated to the study of proteins and their interactions in 35+ organisms and any research thematic. We offer three main lines of services: • Interactions Discovery: ULTImate Y2H™ to discover novel protein-protein interactions in various tissues/cell types o Several adapted versions allow to identify interactions with transmembrane proteins, DNA and RNA o Associated services: Interaction Domain Mapping, Low binders, super binders • Drug Discovery Services (Adapted from ULTImate Y2H) o Target deconvolution: ULTImate YChemH™ to identify on- and off-targets of small bioactive molecules - mechanism of action, polypharmacology, drug repositioning, prediction of toxicity o Protein-protein interactions induced by molecular glues (protein stabilization, targeted protein degradation) • Nanobody® (or Synthetic Antibodies, VHH) to select and validate high-affinity single-domain antibodies (Hybribody™) - for IF, ELISA, high-resolution microscopy, video-microscopy, target inhibition applications but also for diagnosis and therapeutic purposes Our optimized screening platform in yeast enables the identification of the protein partners of proteins, DNA sequences, RNA and small molecules of therapeutic interest. Highly complex protein domain libraries, prepared from any cell type or tissue, are screened to saturation to identify partners and their interacting domains using a transcriptional read-out. Sophisticated bioinformatics analysis allows to attribute confidence scores to each interaction. With more than 3,200 academic and industrial customers from over 40 countries, Hybrigenics Services is internationally recognized. Among our services, our yeast two-hybrid screening technology, ULTImate Y2H, is extensively used in many research projects. The results obtained at Hybrigenics have been quoted in more than 480 scientific publications to date. Hybribody offers single-domain antibody selection and validation services. We handle the in vitro selection of antibodies against your protein from a fully synthetic humanized VHH library by an optimized Phage Display technology. VHHs have the advantages of being very small (15 kDa), affine and stable molecules. We validate the selected VHHs for in vitro and in vivo applications (ELISA, IF, Intrabody…). We can also fuse the VHH with Fc fragments from the species of your choice to deliver fully functional recombinant antibodies. In addition, Hybrigenics Services provides optimization of nanobodies coming from the Llama using yeast display technology. Nanobody® is a trademark of Ablynx.

1-2-20 Shiodome Building 3F Kaigan, Minato-ku Tokyo, 105-0022 JapanInizio is a scaled commercialization platform that unlocks, activates and optimizes value for pharma and biopharma companies at every pivotal moment in the journey from discovery to post-launch . By harnessing our connected platform, we bridge best-in-class scientific expertise, market intelligence, data and analytics, technology, communications and creative execution to help clients make the right strategic choices and maximize the value of their healthcare innovations . Our integrated capabilities span evidence generation, medical communications & publications, market access, HEOR and RWE, data and decision optimization, marketing, PR and communications, medical and promotional engagement, patient engagement, training and events, and management consulting . We orchestrate cross-functional expertise to secure regulatory approval, deliver best-in-class launches, reach the right stakeholders through omnichannel engagement, and drive sustained brand growth throughout the commercialization lifecycle. Purpose-built to navigate complexity and minimize friction, Inizio provides an unrivalled connected offering across all therapeutic areas and geographies – transforming science into value, accelerating access, and ultimately helping more patients receive the medicines they need, faster.

Yokohama, Kanagawa Prefecture JapanIn Silico Biology provides sequence analysis, cloning, gene analysis, homology analysis, genome analysis, and array analysis software.

Kanagawa 231-0023 JapanIn Silico Biology provides sequence analysis, cloning, gene analysis, homology analysis, genome analysis, and array analysis software.

2-15-1 Konan, Minato-ku 港区, Tokyo, 108-6028 JapanInstem provides advanced and best-in-class IT solutions and services to the global health and life sciences community, which help to bring life-changing products to market faster. For the more than 500 clients around the world, we are supplying breakthrough technology and services that help them efficiently access, capture, manage and enrich a wide array of data while generating new insight to advance their mission. Instem clients experience measurable benefits such as: Greater confidence in the safety and efficacy of their product portfolio Shorter R&D cycles with reduced costs Better management controls Increased regulatory compliance More effective resource utilization with greater staff satisfaction Happier and healthier clinical subjects Enhanced care and reduction of animal usage As a result, we enjoy a greater than 98% client retention rate – a statistic that we believe is the true measure of our success. More than just another IT vendor, as a solutions provider we act as a client’s strategic partner helping to optimize their processes, increase the satisfaction of their sponsors and partners while helping them become more competitive in their local, regional and global marketplaces.

2-28-1 Yoshino-cyo, Kitaku, Saitama City,, Saitama, 3310811 JapanGLP-compliant facility for the Kashinho (Chemical Substanses Control Law, CSCL) application. To develop a sustainable society, ecvironment and economy, we privide comprehensive services for the sofety assessment of chemical substances. Since the ecforcement of CSCL in Japan, we have been consistently working on safety of various chemical substances. we conduct safety evaluation tests for chemical substances.

3-1-3 Higashi-Ikebukuro Toshima City, Tokyo, 170-0013 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

13F Ochanomizu Solacity 4-6 Kanda-Surugadai Chiyoda-ku, Tokyo, N/A = Not Applicable, 101-0062 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

4-6 Kanda-Surugadai Chiyoda City, Tokyo, 101-0062 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

1-2-7 Higashiyama, Meguro-ku, TokyoIn-Vivo Science offers in vivo disease model services.

Tokyo, JapanWe provide software and services for management and analysis of next generation sequencing (NGS) data.

Hongo 2-1-1Juntendo University School of Medicine focuses on research.

Fujii Bldg. 3F, 1-4-4 Ueno Taito-ku, Tokyo, 110-0005 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

9-1 Shirokane-5, Minato-kuKitasato University provides protein modeling services.

Minato, Tokyo JapanKitasato University provides protein modeling services.

1 Sakura-machi Hino-shi, Tokyo, 191-8511 JapanKonica Minolta Business Solutions U.S.A., Inc.: is reshaping and revolutionizing the Workplace of the Future.™ The company guides and supports its customers’ digital transformation through its expansive office technology portfolio, including IT Services, ECM, Managed Print Services and comprehensive industrial and commercial printing and packaging solutions that deliver the latest innovations in printing, applications and expertise. Its All Covered IT Services division offers a range of IT strategy, support, and network security solutions across all industries.

18F, Shiodome Sumitomo Bldg, 9-2, Higashi-shimbashi 1-chome, Minato-ku Tokyo, 105-0021 JapanLinical is a public, mid-sized Contract Research Organization headquartered in Japan with a significant presence across all major markets including North America, Europe, and Asia-Pacific. Linical provides the full spectrum of drug development services from early stage to large-scale, multinational studies. Our areas of focus include Phase I-IV studies in oncology, neurology & psychiatry, immunology & vaccine, and endocrinology & metabolic diseases.

18F, Shiodome Sumitomo Bldg, 9-2, Higashi-shimbashi 1-chome, Minato-ku Tokyo, Japan, 105-0021 JapanLinical is a public, mid-sized Contract Research Organization headquartered in Japan with a significant presence across all major markets including North America, Europe, and Asia-Pacific. Linical provides the full spectrum of drug development services from early stage to large-scale, multinational studies. Our areas of focus include Phase I-IV studies in oncology, neurology & psychiatry, immunology & vaccine, and endocrinology & metabolic diseases.

23-23 Honcho, Itabashi-ku, Tokyo 173-0001, JapanLinTec provides manufacturing of pressure-sensitive adhesive materials.

2-20-8, Shinkawa, Chuo-ku, Kyowa Shinkawa Bldg 8F, Tokyo, 104-0033 JapanLonza is one of the world’s largest contract development and manufacturing organizations (CDMOs) dedicated to serving the healthcare industry. Working across five continents, our colleagues work alongside pharma and biotech companies to turn their breakthrough innovations into viable therapies. We support our customers in bringing life-saving and life-enhancing treatments to patients worldwide with a combination of cutting-edge science, smart technology and lean manufacturing.

Mikura Building 3-21-4 Yushima, Bunkyo-Ku, Tokyo, 113-0034, JapanLutronic provides high-quality, affordable medical lasers.

Matrix Science K.K. KN-bldg 3F 6-10-12, Sotokanda Chiyoda-ku Tokyo 101-0021 JapanYou are welcome to submit searches to this free Mascot Server. Searches of MS/MS data are limited to 1200 spectra and some functions, such as no enzyme searches, are unavailable. Automated searching of batches of files is not permitted. If you want to automate search submission, perform large searches, search additional sequence databases, or customise the modifications, quantitation methods, etc., you’ll need to license your own, in-house copy of Mascot Server.

7 Kanda Mitoshiro Cho Chiyoda-ku Tokyo, 1010053 Japan

Chiyoda Japan

千葉県習志野市香澄1-3-7-405 Tokyo, 1-3-7-405 JapanMedicilon is a leading integrated CRO/CDMO providing one-stop drug discovery and preclinical development services to global pharmaceutical, biotechnology, and academic partners. From hit identification and lead optimization to IND-enabling studies, we accelerate the development of innovative therapeutics through a fully integrated platform encompassing medicinal chemistry, biology, DMPK, pharmacology, toxicology, CMC, API process development, formulation, and bioanalytical services. Our flexible collaboration models, including fee-for-service (FFS), dedicated FTE teams, and fully integrated discovery programs which allow us to support projects of any size and stage. Backed by GLP- and GMP-compliant facilities, AAALAC-accredited animal research capabilities, and extensive regulatory experience, Medicilon delivers high-quality, reliable data that supports global IND submissions. By combining scientific expertise, operational efficiency, and seamless cross-functional collaboration, we help clients shorten development timelines and bring promising therapies to patients faster.

千葉県習志野市香澄1-3-7-405 Tokyo, MA, 1-3-7-405 JapanMedicilon is a leading integrated CRO/CDMO providing one-stop drug discovery and preclinical development services to global pharmaceutical, biotechnology, and academic partners. From hit identification and lead optimization to IND-enabling studies, we accelerate the development of innovative therapeutics through a fully integrated platform encompassing medicinal chemistry, biology, DMPK, pharmacology, toxicology, CMC, API process development, formulation, and bioanalytical services. Our flexible collaboration models, including fee-for-service (FFS), dedicated FTE teams, and fully integrated discovery programs which allow us to support projects of any size and stage. Backed by GLP- and GMP-compliant facilities, AAALAC-accredited animal research capabilities, and extensive regulatory experience, Medicilon delivers high-quality, reliable data that supports global IND submissions. By combining scientific expertise, operational efficiency, and seamless cross-functional collaboration, we help clients shorten development timelines and bring promising therapies to patients faster.

1-15-10 Shimura Itabashi-ku Tokyo, 174-0056 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

3-30-1, Shimura Itabashi-ku, Tokyo, 174-8555 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

5F Itabashi-Honcho Bldg, 36-1 Shimizu-cho, Itabashi-ku Tokyo, 174-0053 Japan[Notice] Mediford Corporation was established on November 1, 2023 by combining the drug development support businesses of LSIM Safety Institute Corporation and LSI Medience Corporation, as a member of PHC Group ( https://www.phchd.com/global ). ******** Mediford Corporation offers services that support a wide range of drug research and development from the exploratory phase to clinical testing, leveraging our testing expertise and experience in advanced analysis, which has been accumulated through our established businesses in clinical trials and non-clinical testing. Our services fall into the following three categories: nonclinical study services, bioanalysis services, and central laboratories services. ・Nonclinical study services: Our services include various safety studies, pharmacodynamic and pharmacokinetic studies for regulatory approval applications as well as exploratory studies in the early stages of research and development at facilities compliant with GLP standards including those for pharmaceuticals, medical devices, regenerative medical products, agricultural chemicals, the Chemical Substances Control Law, etc. We also provide services using PDX (patient-derived xenografts) as well as PDC (patient-derived cells). ・Bioanalysis services: We provide analysis services for drugs, their metabolites, biomarkers, etc. in biological samples. We provide comprehensive support from analytical method development to analytical method validation and measurement of actual samples, from the basic research/exploration stage to the verification/clinical development stage. ・Central laboratory services: We conduct centralized testing for clinical research/ trial/ testing samples from nationwide medical institutions, at LSI Medience, the predecessor of our company. This avoids differences in platforms between institutions, unifies testing methodologies and reference ranges, and facilitates data analysis of testing results. We also leverage our overseas laboratories network to support globalization of drug development, responding to our valuable clients’ demands.

Shin-Yokohama Square Bldg. 14F, 2-3-12 Shin-Yokohama, Kohoku-ku, Yokohama, Kanagawa, 222-0033 JAPANMedinet provides immuno-cell therapy services as well as research and development.

Kuboi bldg 6F, Nihonbashi Horidome-cho 1-1-9 Chuo-ku Tokyo, 103-0012 JapanMediridge Co.,Ltd, we carry out various bio-related testing and bio production contract for pharmaceutical, diagnostics companies and academic researchers in Japan.

1-5-8, KYOBASHI, CHUO-KU, TOKYO 104-8305, JAPANMercian focuses on drug discovery research and offers fermentation services.

4-2-8, Shibaura, Minato-ku, Tokyo, JapanMitsubishi Chemical Medience Corporation offers genotoxicit, safety pharmacology, efficacy testing, biomarker, proteomics, screening and genotyping services.

2-5-1 Atago Atago Green Hills MORI Tower Minato-ku, Tokyo, 105-6215 JapanMitsui Knowledge Industry Co., Ltd. (MKI) provides comprehensive bioinformatics services to public research institutions, universities, and pharmaceutical companies. MKI now offers its proprietary software “AQXeNA”, a powerful analytical platform designed to automatically identify and quantify XNA from large-scale mass spectrometry data obtained through LC-MS experiments. The key advantage of using AQXeNA lies in its ability to analyze the detailed internal structures of nucleic acid sequences, including modified nucleic acids. Moreover, it supports long-chain nucleic acid sequences spanning several thousand bases. The insights gained from such analyses are essential for drug discovery and R&D in nucleic acid therapeutics and mRNA vaccine development.If you are interested in nucleic acid analysis using LC-MS data, our contract data analysis services, or have any questions, please feel free to contact us. Product information is also available on our website. Please visit the link below for further details. https://www.mki.co.jp/english/product/aqxena/

2-6-11 Mejirodai, Hachioji-city, Tokyo, Japan

7, Yotsuya 1-chome, Shinjuku-ku, Tokyo 160-8515, JapanMochida Pharmaceutical specializes in production and development of cardiovascular, obstetrics, gynecology, dermatology, emergency, and psychiatry medicine.

Seven Bldg. 4F ３丁目-７-14 日本橋人形町 中央区 東京都 103-0013 Japan 中央区, 東京都, 103-0013 JapanMP Biomedicals is dedicated to giving scientists and researchers innovative, quality tools and superior service to aid them in their quest for ground-breaking discovery and turning the hope for life-changing solutions into a reality. The company manufactures and sells more than 55,000 products and is one of the only companies in the industry to offer a comprehensive line of life science, fine chemical and diagnostic products. MP Biomedicals is a world-wide corporation, with ISO-certified and FDA-approved manufacturing and distribution facilities throughout the globe and headquartered in Southern California. A vast network of global distributors and satellite facilities and offices throughout Europe, Asia, Australia and the Americas assures customers top quality products delivered when and where needed. No matter how dynamic the evolution of the life science and biotechnology markets, we remain committed to supporting our customers in their efforts to make new discoveries. From basic research, through scale-up, to full-scale production and diagnostic testing, MP Biomedicals serves every industry need – from specialized areas of research to supplying large scale quantities of fine chemicals. Our customers partner with us because they want a long-time player and reliable colleague in the fields of life science research and diagnostics. MP Biomedicals will never rest in our odyssey to remain at the forefront of discovery in the ever-changing biomedical industry.

2-10-3 Nagatacho, Tokyu Capitol Tower Chiyoda-ku, Tokyo, 100-0014 JapanCompany Overview: MRI Research Associates, Inc. MRI Research Associates, Inc. (MRA) is a Japan-based research and consulting firm and a core member of the Mitsubishi Research Institute (MRI) Group. Established in 1984, MRA provides highly specialized research, data analysis, and quantitative modeling services, primarily supporting public-sector policy development and evidence-based decision-making in Japan. As a technical think tank, MRA integrates policy research expertise with advanced data science, statistical analysis, and simulation technologies. The company works closely with central government ministries, local governments, and public institutions, contributing to EBPM (Evidence-Based Policy Making) across a wide range of societal and economic domains. Core Business Areas MRA’s services span multiple interdisciplinary fields, including: Research and consulting services for public policy and social systems Data science and statistical surveys, including the design and operation of official statistics Quantitative analysis and simulation, covering natural and social phenomena Project and program management support (PMO) for large-scale research and public projects. Areas of Expertise The company addresses complex societal challenges in areas such as: National land, regional and urban planning Transportation and infrastructure Healthcare, nursing care, and social welfare Disaster prevention and public safety Energy, environment, and sustainability Demographics, labor markets, and economic forecasting. Position within the MRI Group Within the Mitsubishi Research Institute Group, MRA plays a key role as a technical and analytical backbone for government-oriented think tank activities. It complements MRI’s policy design capabilities by delivering rigorous data handling, modeling, and empirical analysis, thereby supporting the group’s mission of solving complex societal issues through “Think Tank × IT” collaboration.

5-1, Nihonbashi-Kobunacho, Chuo-ku, Tokyo 103-8355, JapanNagase provides resins, enzymes, antibodies, screening, gene expression, and silicone materials.

8-14-5 Ginza Chuo City, Tōkyō-to, 104-0061 JapanNAMSA is a Medical Research Organization (MRO), accelerating product development through integrated laboratory, clinical and consulting services. Driven by our regulatory expertise, NAMSA’s MRO® Approach plays an important role in translational research, applying a unique combination of disciplines—consulting, preclinical, toxicology, microbiology, chemistry, clinical and quality—to move client’s products through the development process, and continue to provide support through commercialization to post-market requirements, anywhere in the world.

1-3-1 Kasumigaseki Chiyoda-ku Tokyo, 100-8921 JapanThe National Institute of Advanced Industrial Science and Technology (AIST), one of the largest public research organizations in Japan, focuses on the creation and practical realization of technologies useful to Japanese industry and society, and on “bridging” the gap between innovative technological seeds and commercialization. For this, AIST is organized into 5 departments and 2 centers that bring together core technologies to exert its comprehensive strength. AIST, as a core and pioneering existence of the national innovation system, has about 2000 researchers doing research and development at 10 research bases across the country, based on the national strategies formulated with the changing environment involving innovation in mind. AIST is also actively building a global network by, for example, signing memorandam of understanding for comprehensive research cooperation (MOUs) with 30 major research institutes around the

1-3-1 Kasumigaseki, Chiyoda-ku, Tokyo 100-8921 JapanThe National Institute of Advanced Industrial Science and Technology (AIST), one of the largest public research organizations in Japan, focuses on the creation and practical realization of technologies useful to Japanese industry and society, and on “bridging” the gap between innovative technological seeds and commercialization. For this, AIST is organized into 5 departments and 2 centers that bring together core technologies to exert its comprehensive strength. AIST, as a core and pioneering existence of the national innovation system, has about 2000 researchers doing research and development at 10 research bases across the country, based on the national strategies formulated with the changing environment involving innovation in mind. AIST is also actively building a global network by, for example, signing memorandam of understanding for comprehensive research cooperation (MOUs) with 30 major research institutes around the

2-5-1 HigashigaokaNational Institute of Sensory Organs focuses on research in vision and hearing impairment.

4-10-9, Takaido-higashi, Suginami-ku, Tokyo 168-0072, JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

4-10-9, Takaido-higashi Suginami-ku Tokyo, 168-0072 JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

6136-4, Ohnogo-machi, Joso-city, Ibaraki-ken 300-2521 JapanNemoto Science, a subsidiary of Nemoto, offers custom synthesis, in vivo/in vitro pharmacokinetic and toxicokinetic analysis, and metabolite identification services.

5-3-13, Mita, Minato-ku Tokyo, JapanNippon Shikizai is a contract cosmetics manufacturing service solution provider.

Hibiya Dai Bldg., 1-2-2 Uchisaiwai-cho, Chiyoda-ku, Tokyo, 100-0011 JapanNIPPON SHOKUBAI is a Japan based CDMO for oligonucleotide and peptide. In addition to wide range of API manufacturing scale, we offer one-stop shop service to accelerate clients' project. As a provider of both technical and logistical solutions, NIPPON SHOKUBAI use our experience and connections to help our clients accelerate their R&D activities and develop effective manufacturing strategies: - Supporting development & commercialization for oligonucleotide and peptide APIs. - Leveraging technology to drive next-generation drug discovery modalities. We have established a system suitable for exploratory research to clinical trials, which enables us to offer a variety of solutions: - Small-scale synthesis for drug efficacy and toxicity evaluation in the drug discovery stage - Contract research on process and testing methods for pilot manufacturing - GMP-compliant API manufacturing for clinical trials Also, we offer a variety of manufacturing scales ranging from a few mg in the exploratory research stage to kg in the late clinical stage. NIPPON SHOKUBAI is a Japanese chemical company which has world-class production capacity of superabsorbent polymer and has supplied many valuable products with its unique organic synthesis technology. We've made successful advancements in health & medicine field by integrating new and conventional technologies. With a wealth of expertise in the development of investigational and commercial drugs, we are now the partner of choice for biotech and pharmaceutical companies.

Hibiya Dai Bldg., 1-2-2 Uchisaiwai-cho, Chiyoda-ku, Tokyo, Tokyo, 100-0011 JapanNIPPON SHOKUBAI is a Japan based CDMO for oligonucleotide and peptide. In addition to wide range of API manufacturing scale, we offer one-stop shop service to accelerate clients' project. As a provider of both technical and logistical solutions, NIPPON SHOKUBAI use our experience and connections to help our clients accelerate their R&D activities and develop effective manufacturing strategies: - Supporting development & commercialization for oligonucleotide and peptide APIs. - Leveraging technology to drive next-generation drug discovery modalities. We have established a system suitable for exploratory research to clinical trials, which enables us to offer a variety of solutions: - Small-scale synthesis for drug efficacy and toxicity evaluation in the drug discovery stage - Contract research on process and testing methods for pilot manufacturing - GMP-compliant API manufacturing for clinical trials Also, we offer a variety of manufacturing scales ranging from a few mg in the exploratory research stage to kg in the late clinical stage. NIPPON SHOKUBAI is a Japanese chemical company which has world-class production capacity of superabsorbent polymer and has supplied many valuable products with its unique organic synthesis technology. We've made successful advancements in health & medicine field by integrating new and conventional technologies. With a wealth of expertise in the development of investigational and commercial drugs, we are now the partner of choice for biotech and pharmaceutical companies.

8-1, Minamisakae-cho, Kasukabe, Saitama 344-0057, JapanNipro Patch provides transdermal therapeutic preparations and products.

1-10-5, Nihonbashihon-cho, Chuo-ku, Tokyo 103-0023Nissan Chemical offers custom synthesis and manufacturing services.

6F, 1-17-24 Shinkawa, Chuo-ku, Tokyo 104-0033Nitto Medic specializes in manufacturing and selling opthalmic drugs.

Bunshokudan Bldg. 7F Kudanminami 1-4-5 Chiyoda-ku Tokyo 102-0074Novasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

7th building 210, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-0054, JapanNoveltec supports study in disease animal models through software and examination systems.

KBIC#217, 7-7, Shinkawasaki, Saiwai-ku, Kawasaki-shi, Kanagawa 212-0032, JapanOur mission at ORGANOGENIX, Inc., as a leading company of three-dimensional (3D) cell culture technology, is to provide products and technical support to scientists worldwide to bring innovation to life science research, which leads to breakthroughs in drug discovery and achievement of a longevity society. Our 3D Vison Dedication We are dedicated to the further exploration of the 3D cell culture method and through our expertise and products, bring a new perspective to promote innovation in the field of life science. Discovery Our vision, by advancing bioscience research with our 3D model, is to contribute to the creation of novel drugs and medicines, diagnostic technologies and other medical innovations and discoveries. Dream We dream to achieve a healthy society, that our 3D technology contributes to medical research breakthroughs leading to overcome intractable diseases, increase the human health span, and enhance disease preventions.

KBIC#217, 7-7 Shinkawasaki, Saiwai-ku Kawasaki-shi, Kanagawa, 212-0032 JapanOur mission at ORGANOGENIX, Inc., as a leading company of three-dimensional (3D) cell culture technology, is to provide products and technical support to scientists worldwide to bring innovation to life science research, which leads to breakthroughs in drug discovery and achievement of a longevity society. Our 3D Vison Dedication We are dedicated to the further exploration of the 3D cell culture method and through our expertise and products, bring a new perspective to promote innovation in the field of life science. Discovery Our vision, by advancing bioscience research with our 3D model, is to contribute to the creation of novel drugs and medicines, diagnostic technologies and other medical innovations and discoveries. Dream We dream to achieve a healthy society, that our 3D technology contributes to medical research breakthroughs leading to overcome intractable diseases, increase the human health span, and enhance disease preventions.

2-38-5 Nishishimbashi, Minato-ku, Tokyo 105-8433, JapanDevelopment, manufacture and sale of healthcare devices and services ( in vitro diagnostic devices, medical IT solutions, life science devices and services, etc.)

7F Wakamatsu Building, 3-3-6 Nihonbashi Hon-cho, Chuo-ku, Tokyo 103-0023 JapanPatheon is the leading publicly listed provider of drug development and manufacturing services to global pharmaceutical, biotechnology and specialty pharmaceutical companies.

Business Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904Business Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904

3-25-23, Tonomachi, Kawasaki-ku Kawasaki-shi, Kanagawa, 210-0821 JapanBusiness Offices, KOL Building, room 405 Research Labs, KOL Building, 4th floor Komaba Research Campus (Komaba Ⅱ) The University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo JAPAN 153–8904

Tokyo JapanPerseus Proteomics supplies antibodies against proteins and transcription factors involved in vascular inflammation and offers ELISA kits.

4-7-6, Komaba Meguro-ku Tokyo, 153-0041 JapanPerseus Proteomics supplies antibodies against proteins and transcription factors involved in vascular inflammation and offers ELISA kits.

Tokyo JapanPharmaCo-Cell offers in vitro Blood-brain barrier (BBB) model for the drug permeability assay.

Rop 806, Ark Hills Front Tower 2-23-1 Akasaka Toyko, Minato, 107-0052 JapanPHT International is a 32-year-old, woman-owned, minority business headquartered here in Charlotte. We specialize in the supply of fine chemicals and intermediates to industries including cosmetics, personal care, polymers, industrial applications, and pharmaceuticals. Our global supply capabilities include in-house production at our facilities in China, joint ventures in China and India, and partnerships with select manufacturers that provide advanced fine chemical technologies.

2-7-11 Shimotakaido Suginami-ku Tokyo, Japan 168-0073Plexera provides label-free screening services on the high-throughput PlexArray HT screening platform, providing flexibility in project size and experimental design.

Nippon Roper, K. K. Sakurai Building 2-8-19 Fukagawa, Kotu-Ku Tokyo 135-0033, JAPAN Princeton Instruments (PI) designs and manufactures high-performance CCD, ICCD, EMCCD, emICCD, and InGaAs cameras; spectrographs; and optics-based solutions for the scientific research, industrial imaging, and OEM communities. We take pride in partnering with our customers to solve their most challenging problems in unique, innovative ways. PI operates as a unit of Roper Technologies, a diversified growth company and a constituent of the S&P 500, Fortune 1000, and Russell 1000 indices. Roper provides engineered products and solutions for global niche markets, including water, energy, transportation, medical, education, and SaaS-based information networks. Princeton Instruments has two U.S. manufacturing facilities, one located in New Jersey (Trenton) and one in Massachusetts (Acton). Our worldwide sales and service organizations in Germany, France, the United Kingdom, Japan, China, and Singapore provide sales support and discuss application requirements in addition to being your local contacts for order processing and service. Capabilities: Princeton Instruments possesses core technological capabilities in several key areas: Scientific Imaging: High-performance CCD, ICCD, EMCCD, emICCD, and InGaAs cameras for an expansive range of applications, including astronomy, BEC, combustion, PIV, single-molecule imaging, surface and materials analysis, PSP, and nanotechnology. Spectroscopy: A wide selection of state-of-the-art CCD cameras, spectrographs, monochromators, and integrated systems for Raman, LIBS, absorption, fluorescence, NIR/SWIR, and luminescence spectroscopy. X-ray Imaging: Advanced scientific-grade CCD cameras for x-ray applications such as EUV, lithography, XRS, plasma, diffraction, microscopy, and tomography. Optics & Coatings:

Daiichi Enoki Bldg. 4F 5-3-1, Toranomon, Minato-ku, Tokyo 105-0001 JapanProPharma Partners provides a broad range of advisory and consulting services to biotechnology and pharmaceutical industries.

Chiba Univ. Innovation Plaza, 1-8-15 Inohana, Chuo-ku, Chiba-shi, Chiba 260-0856, Japan.The goal of ProteinExpress, an R & D oriented company, is to become an important base for proteomics and, as its core business, conduct drug discovery research in the post-genome era. This is possible by making the best use of its fully comprehensive protein expression technology. ProteinExpress focuses its business on exploring and validating seeds of novel drugs as a genome-based drug discovery company. Our business is based on recombinant DNA technology for effective protein production. Genome-based Drug Seed Development Projects Genome-based Drug Discovery Project - Targeting genes for drug discovery - Identifying target proteins by proteomics - Validating drug seeds KIAA Project - Producing antibodies as a proteome analysis tool - Proteomics with the utilization of antibodies

Room 5108, Annex Building, AIST Tokyo Waterfront,2-4-7 Aomi Koto-ku, Tokyo, 1350064 JapanProteobridge contributes to the elucidation of the pathogenesis of autoimmune diseases and the creation of new diagnostic methods. We continue to promote research on autoantibodies and autoimmune diseases in collaboration with physicians and researchers around the world by utilizing our unique protein array technology. - Overview of our Service HuPEX® is a contract service specializing in comprehensive antibody profiling against human proteins (over 13,000 proteins). The service enables large-scale analysis of antibodies present in serum, plasma, or purified antibody samples, providing systematic profiling of antibody reactivity to human proteins. Website https://proteo-bridge.co.jp/en/service/hupex/ -Applications This service supports a wide range of research applications, including: Biomarker discovery Antigen identification Disease monitoring Comparative analysis before and after treatment Specificity verification of drug candidate antibodies

TokyoQuanticate offers clinical research services including data management, statistical consultancy/programming/analysis, medical writing, and pharmacovigilance.

KDX Shin-yokohama 381 Bldg. 9F 3-8-11 Shin-yokohama, Kohoku-ku Yokohama, Kanagawa, 222-0033 JapanREPROCELL IMPROVING HUMAN HEALTH THROUGH BIOMEDICAL INNOVATION AND DISCOVERY. REPROCELL is dedicated to providing researchers with single-source solutions for the advancement of stem cell and human tissue research in drug discovery and regenerative medicine. With facilities in the USA, Europe, and Japan, our services are available to our clients worldwide. REPROCELL brands include: BIOPTA • Predictive safety, efficacy and ADME assays in human (and animal) fresh functional tissues for drug development BIOSERVE • Extensive biorepository of human tissue samples from a wide range of patients including COVID-19 • Large network of clinical sites for prospective sample collection • Molecular genomic services STEMGENT • iPSC reprogramming services with RNA reprogramming systems • Clinical GMP iPSC Services • Differentiation services into neurons and other cell types • CRISPR-SNIPER gene editing services

MetLife Shin-yokohama Bldg. 9F, 3-8-11, Shin-yokohama, Kohoku-ku, Yokohama,, Kanagawa, 2220033 JapanREPROCELL IMPROVING HUMAN HEALTH THROUGH BIOMEDICAL INNOVATION AND DISCOVERY. REPROCELL is dedicated to providing researchers with single source solutions for the advancement of stem cell and human tissue research in drug discovery and regenerative medicine. With facilities in the USA, Europe, and Japan, our services are available to our clients worldwide.

Tokyo, Tokyo JapanReqMed provides drug development and pharmaceutical consulting.

Mitsui-Life Bldg. 1-7-23 Morino, Machida-City, Tokyo 194-0022, JapanReqMed provides drug development and pharmaceutical consulting.

Central2, 1-1-1, Umezono, Tsukuba, Ibaraki, 305-8568 JapanResearch Center for Med. Glycoscience offers sugar chain profiling, biomarkers, and diagnostics for drug development.

Shonan Health Innovation Park, 2-26-1, Muraoka-Higashi Fujisawa, Kanagawa, 251-8555 JapanRicoh Biosciences (formerly Elixirgen Scientific), established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● Custom Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Differentiated Cell Supply : Ricoh Biosciences delivers high-quality, fully characterized iPSC-derived cells through rigorously validated differentiation protocols. Our cells are ready for research and preclinical applications, providing researchers with reliable, reproducible results for their most critical studies. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

2-26-1, Muraoka-higashi, Shonan-iPark Fujisawa-city, Kanagawa, 2518555 JapanRicoh Biosciences (formerly Elixirgen Scientific), established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● Custom Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Differentiated Cell Supply : Ricoh Biosciences delivers high-quality, fully characterized iPSC-derived cells through rigorously validated differentiation protocols. Our cells are ready for research and preclinical applications, providing researchers with reliable, reproducible results for their most critical studies. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

Rm 409, Life Innovation Center 3-25-22, Tonomachi, Kawasaki-ku Kawasaki, Kanagawa, 210-0821 JapanRicoh Biosciences (formerly Elixirgen Scientific), established in 2016, is a Maryland-based biotechnology firm specializing in iPSC-related technology. Our mission is to dedicate ourselves to quality, innovation, and collaboration, which drives the development of cutting-edge discoveries and therapies through the power of iPSC technology. We are focused on: ● Custom Cell Type Development Partnership: Engage in a strategic partnership focused on creating clinically relevant and functional cells. These cells find applications in neurodegenerative drug screening and cell therapy, contributing to the evolution of medical solutions. ●Differentiated Cell Supply : Ricoh Biosciences delivers high-quality, fully characterized iPSC-derived cells through rigorously validated differentiation protocols. Our cells are ready for research and preclinical applications, providing researchers with reliable, reproducible results for their most critical studies. ●Translational Research Partnership with Patient-Derived Disease Model: Collaborate with us in translational research, benefitting from disease panel assays tailored to your specific needs. Our expertise extends to diseases such as Alzheimer's, Parkinson's, rare diseases and regenerative medicine.

Rigaku Corporation 3-9-12, Matsubara-cho Akishima-shi Tokyo, 196-8666 JapanRigaku offers services for electron diffraction crystallography exclusively. Rigaku is furthermore a market-leading manufacturer of instruments for electron diffraction crystallography and x-ray crystallography, x-ray diffraction, x-ray spectrometry, semiconductor metrology, automation, and cryogenics.

4-14-4, Sendagaya, Shibuya-Ku,Rigaku offers services for electron diffraction crystallography exclusively. Rigaku is furthermore a market-leading manufacturer of instruments for electron diffraction crystallography and x-ray crystallography, x-ray diffraction, x-ray spectrometry, semiconductor metrology, automation, and cryogenics.

1-7-22 Suehiro-cho, Tsurumi-ku Yokohama 230-0045 Japan

2-1 Hirosawa Wako, Saitama, 351-0198 Japan

Cell Engineering Division / RIKEN BioResource Center 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, JapanThe RIKEN BioResource Center (BRC) is a non-profit institution funded by the Japanese Government. We have been engaging in collection, preservation and distribution of bioresources, with the aim to support research and development in the field of life sciences. We provide bioresources to scientists not only in Japan but also throughout the world with minimum fees that is solely reimburse for preparation and handling costs of the requested bioresources. To continue the smooth distribution of bioresources for overseas organizations, it has become necessary to send bioresources prepaid. We sincerely hope that this change will not cause any inconvenience our users. We very much appreciate your understanding and cooperation, and are looking forward to receiving your requests for our bioresources.

, Tsukuba Tsukuba-shi, Ibaraki-ken 305-0074, JPOur division was established in 1987 as the RIKEN Gene Bank. When the RIKEN BioResource Center was established in 2001, the bank was recognized as Gene Engineering Division. Since 2002, the Division has been selected as a core facility of DNA resources by National BioResource Project funded by the Ministry of Education, Culture, Sports, Science and Technology, Japan for collection, quality control, preservation and distribution of genetic materials of human, animal and microbe origin.

3-1-1 Koyadai Tsukuba Ibaraki, 305-0074 JapanOur division was established in 1987 as the RIKEN Gene Bank. When the RIKEN BioResource Center was established in 2001, the bank was recognized as Gene Engineering Division. Since 2002, the Division has been selected as a core facility of DNA resources by National BioResource Project funded by the Ministry of Education, Culture, Sports, Science and Technology, Japan for collection, quality control, preservation and distribution of genetic materials of human, animal and microbe origin.

5-1-17 Sakurajosui Setagaya-ku, Tokyo 156-0045 JapanROW2 Technologies specializes in synthetic organic chemistry, cheminformatics, and chemical knowledge bases.

NihonBashi Core Bldg, Chuou-ku NihonBashi Horidome-Chou 2-8-4, Tokyo, JapanRUNDO-CRONOVA offers clinical trial management, statistics services, regulatory affairs, and consulting.

38 MoroyamaSaitama Medical University focuses on research with departments in molecular biology, biochemistry, pharmacology, immunology, and microbiology.

DF Kasumigaseki Place,3-6-7 Kasumigaseki Chiyoda-ku, Tokyo 100-0013 JAPANSCETI Bioscience offers immunoassays, proteins, DNA, antibodies, cell culture products and services.

13F Marunouchi Trust Tower North 1-8-1 Marunouchi Chiyoda-ku, Tokyo, 100-0005 JapanSchrodinger provides visualization / simulation scientific software as well as Technology / Modeling services for Life sciences and Materials science customers globally.

13F Marunouchi Trust Tower North 1-8-1 Marunouchi Chiyoda-ku, Tokyo, 100-0005 JapanSchrodinger provides visualization / simulation scientific software as well as Technology / Modeling services for Life sciences and Materials science customers globally.

Kanagawa Science Park East 502 3-2-1 Sakado, Takatsu-ku, Kawasaki-shi Kanagawa 213-0012, JapanSCIVAX specializes in 3D cell culture, cancer drug screening, and nanoimprint prototyping.

Kanagawa Science Park East Kawasaki, Kanagawa JapanSCIVAX specializes in 3D cell culture, cancer drug screening, and nanoimprint prototyping.

Fujisawa, Kanagawa Prefecture, 251-0012 JapanWe provide two services for successful discovery of small molecule drugs using our Binder Selection Technology. 1. Compound screening We select the compound that binds to the target from the compound library* using our technology. All proteins are targeted. Membrane proteins are used without solubilization. * We use the compound library owned by Takeda Pharmaceutical Company Limited. 2. Target identification We select the protein that binds to the compound from the protein library with one protein per well using the binder selection technology. Membrane proteins can also be examined. Chemical modification of compounds and proteins is unnecessary. This service makes protein identification easier.

26-1, Muraoka-Higashi 2-Chome Fujisawa, Kanagawa, 251-0012 JapanWe provide two services for successful discovery of small molecule drugs using our Binder Selection Technology. 1. Compound screening We select the compound that binds to the target from the compound library* using our technology. All proteins are targeted. Membrane proteins are used without solubilization. * We use the compound library owned by Takeda Pharmaceutical Company Limited. 2. Target identification We select the protein that binds to the compound from the protein library with one protein per well using the binder selection technology. Membrane proteins can also be examined. Chemical modification of compounds and proteins is unnecessary. This service makes protein identification easier.

Tokyo JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

6-1, Marunouchi 1-chome, Chiyoda-ku Tokyo 100-0005, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

1253, Tateno 3-chome, Higashiyamato-shi Tokyo 207-0021, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

3-1, Kurihama 7-chome, Yokosuka-shi Kanagawa 239-0831, JapanSeikagaku offers pharmaceuticals and medical devices specifically related to glycoconjugates.

3. Kanda-Nishikicho 1-chome, Chiyoda-ku, Tokyo 101-8448, JapanShimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

Guranderu Mizonokuchi 706 1-chome-19-11 Mizonokuchi Kawasaki City, Kanagawa, 2130001 JapanSino Biological is a global leader in recombinant protein and antibody production and CRO services for life sciences research and drug development. Its facilities include the Center for Bioprocessing (C4B) in Houston, Texas, which specializes in mammalian cell-based protein and antibody production, and SignalChem Biotech (SCB) in Vancouver, Canada, focusing on kinase-related reagents, stable cell line development, and therapeutic discovery. With a U.S. office providing localized support, Sino Biological ensures innovative, high-quality solutions for global academic and industrial clients.

4th Floor, Dai2 Nagai Building 4-4-13 Nihonbashihoncho Chuo-ku, Tokyo 103-0023 Japan

Tokyo, Tokyo Japan

2-16-1 Minami-Kamata Ota Tokyo, 1440035 JapanSMC Laboratories has been supporting nonclinical pharmacology research for almost 10 years, with over 700 clients globally. It is our proprietary STAM™ mice that has made us a leading CRO in the NASH-HCC research field. In addition to our strong expertise in liver research, SMC Laboratories has accumulated know-how in various experimental conditions associated with NASH, such as metabolic disorders, diabetes, inflammation, fibrosis and cancer, and expanded our service to various other organs and diseases, including pulmonary fibrosis, systemic sclerosis, and chronic kidney disease.

Tokyo, Tokyo JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Fuchinobehoncho 5 - 14 - 12, Sagamihara-City,Kanagawa JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Nippon Bldg., 2 - 6 - 2 Ohtemachi, Chiyoda-Ku,Tokyo JapanSogo Pharmaceutical offers pharmaceuticals, cosmetics, chemicals and custom synthesis.

Nishi Shinbashi 1Chome Kawate Bill 8F 801 1-5-8, Nishi Shinbashi, Minato-Ku, Tokyo 105-0003 JapanSongwon is the second largest manufacturer of polymer stabilizers in the world. Our vision is to be Salient in Additives and become the supplier of choice for polymer additives through our continued commitment to providing better quality, better service and better value to our customers. We are firmly focused on delivering growth by anticipating the needs and desires of our customers and by aspiring to be a leading example in additives technology development.

4-20-1, Koishikawa, Bunkyo-ku, Tokyo, 112-0002, JapanSO-TI provides an online search service of patent databases in the USA and Japan.

RBM Kyobashi Bldg. 3-4-8 Hatchobori Chuo-ku, Tokyo, 104-0032 JapanSRD Co., Ltd. was established in 1989 as a company that specializes in supporting clinical research and development including data management, site selection, study monitoring, statistical analysis, regulatory consulting, and medical writing. Since then, we have provided support services for many clinical trials and have broadly consulted on development and regulatory applications for pharmaceuticals as well as medical devices, quasi-drugs and specified health foods. In response to changes in pharmaceutical development trend, we have built our track record as support specialist for research and development of unmet medical needs and new, highly challenging drugs. Although we are an independent and middle sized CRO, by making full use of our mobility and a wide network of information which can be compared to other competitors in the industry, we are confident that we have a system for providing services with reliable quality in any area and for responding to the diverse needs and requirements of our clients. The basic principles in providing our services are as follows: ・We execute our duties faithfully as a partner who shares the client’s perspective. ・We seek mutual growth and development with our clients by assisting with the achievement of their aspirations and fulfillment of their potential through support of their development initiatives. SRD Group is providing not only full CRO service, but also providng full SMO ervice in Japan and Vietnam so that we have capabilities to manage, operate, and complete your product development in Japan 2015, SRD established Asia Clinical Trial Support Alliance consisted with CROs and SMOs called CSIA (Clinical Service in Asia) in Asian region including Japan, China, Korea, Taiwan, and Vietnam for worldwide pharmaceutical companies and other regional CROs. CSIA is consisted with top ranked 8 companies form above countries and region, and looking for local independent CROs and SMOs to have a partnership in Asian region for our customers to support entire clinical trial in Asia. CSIA web site is now updating especially for Korea part, but please refer to the details of CSIA through web site (http://www.cro-srd.co.jp/csia/en/). We look forward to your continued support and partnership.

6, Kitahara, Tsukuba, Ibaraki, 300-3266, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

9-1, Kitasode, Sodegaura, Chiba, 299-0266, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Sumitomo Fudosan Hongo Building, 3-22-5, Hongo, Bunkyo-ku, Tokyo, 113-0033, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Tokyo Sumitomo Twin Building (East), 27-1, Shinkawa 2-chome, Chuo-ku, Tokyo 104-8260, JapanSumitomo Chemical Europe is the European Sales & Marketing office of Sumitomo Chemical Co. Ltd.. Our office is responsible for the sales & marketing of regulatory starting materials, GMP intermediates, and API in Europe and the United States . We are the leading Japanese CDMO for small molecules and high-purity long oligonucleotides (100mer - 200mer+) with unmatched service and reliability.

104-8260 JapanSumitomo Chemical Europe is the European Sales & Marketing office of Sumitomo Chemical Co. Ltd.. Our office is responsible for the sales & marketing of regulatory starting materials, GMP intermediates, and API in Europe and the United States . We are the leading Japanese CDMO for small molecules and high-purity long oligonucleotides (100mer - 200mer+) with unmatched service and reliability.

Hulic Kudan Building 1-13-5 Kudan Kita, Chiyoda-ku, Tokyo 102-0073, JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

2008-2 Wada Tama-city Tama-city, Tokyo, 206-0001 Japan

Minato Mirai Grand Central Tower 7F　 4-6-2, Minatomirai, Nishi-ku Yokohama, Kanagawa, 2208561 Japan

Fuju Bldg. 5-30-9 Shiba, Minatku Tokyo, Japan, 108-0014 Japan

2-5 Nihonbashi-honcho 2-Chome, Chuo-ku, Tokyo, 103-0023 JapanTeikoku Seiyaku offers development, manufacturing and sales of medicated and medically related supplies.

4321, Uchimoriya-machi Joso-shi, Ibaraki, 303-0043 JapanThe Institute of Environmental Toxicology (IET) in Ibaraki, Japan is a reputable research organization specializing in conducting comprehensive toxicology studies that has supported the registration of agrochemicals for over 50 years. IET collaborates with clients to evaluate the safety of their products. Extensive testing is available, including toxicity studies (e.g. acute oral toxicity, 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, and 4-week immunotoxicity studies), eco-tox, metabolism studies (in soil, water, crops) and residue studies (in soil, water, crops). IET is AAALAC accredited and conducts research to Good Laboratory Practice (GLP) standards, showcasing our commitment to thorough research and ensuring consumer safety.

Uchimoriya machi 4321 Mitsukaido shi, 303 Ibaraki JapanThe Institute of Environmental Toxicology (IET) in Ibaraki, Japan is a reputable research organization specializing in conducting comprehensive toxicology studies that has supported the registration of agrochemicals for over 50 years. IET collaborates with clients to evaluate the safety of their products. Extensive testing is available, including toxicity studies (e.g. acute oral toxicity, 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, and 4-week immunotoxicity studies), eco-tox, metabolism studies (in soil, water, crops) and residue studies (in soil, water, crops). IET is AAALAC accredited and conducts research to Good Laboratory Practice (GLP) standards, showcasing our commitment to thorough research and ensuring consumer safety.

Dogenzaka Square Suite 503, Floor 5, 5-18 Shibuya-Ku, Tokyo, JapanTheorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

Tokyo, Tokyo JapanTheravalues Corporation provides nuclear receptor analysis and proteomics analysis services.

University of Tokyo Entrepreneur Plaza 7-3-1 Hongo Tokyo, Bunkyo-ku, 113-0033 JapanThinkCyte, founded in 2016 and headquartered in Tokyo, Japan, is a biotechnology company developing innovative products for life science research, diagnostics, and therapeutic discovery & development using integrated multidisciplinary technologies (microfluidics, advanced optics, and machine learning). The company has pioneered Ghost Cytometry, a proprietary image-based high-throughput label-free cell sorting technology initially published in Science in 2018. In June 2019, the company was selected for J-Startup by the Ministry of Economy, Trade and Industry of Japan. ThinkCyte is developing commercially available instruments for the life science R&D market and also engages in collaborative research with leading biopharmaceutical companies, clinical research centers, and academic institutes. For more information, please visit our website (https://thinkcyte.com).

Higashi Ikebukuro Tokyo 170-0013 JapanFounded in 1989, Thorlabs has its headquarters in Newton, NJ. This location is also home to our mechanics, optics, fiber, advanced systems technology, and advanced applications teams as well as one of our three distribution warehouses. On-site manufacturing allows us to customize our products quickly and efficiently to meet specialized customer requests. Our technical support team, call center, marketing, and web development teams make their homes in Newton as well, and are dedicated to providing comprehensive customer support and services.

Tokyo JapanTMRC specializes in the development of anti-cancer products.

1-10-11, Hamamatsucho, Minato-ku, Tokyo 105-0013, JAPANTMRC specializes in the development of anti-cancer products.

Tokyo, Tokyo JapanToa Pharmaceutical specialize in supplying bacterial probiotics.

2-1-11, Sasazuka, Shibuya, Tokyo 151-0073, JapanToa Pharmaceutical specialize in supplying bacterial probiotics.

Bunkyō-ku, Tōkyō-to, 113-0034 Japan

Tokyo Research Laboratory 2743-1, Hayakawa, Ayase, Kanagawa 252-1123, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

3-8-2 Shiba, Minato-KuTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

2-1 Nihonbashi-Odenmacho Chuo-ku, Tokyo, 1030011 Japan■About Trans Chromosomics Our company was founded in 2014 to put the research outcomes of basic chromosome researches over 40 years into practical use. The beginning of the application of the chromosomal engineering research to medicine was the development of human mono chromosome library and the chromosome transfer technology. In the 1990's, we succeeded in developing the first fully human antibody-producing mouse in the world through collaboration research with Kirin Brewery Co., Ltd. (present Kyowa Hakko Kirin Co., Ltd.). This result has opened up a new era of antibody drugs. In the next 20 years, the foundation of artificial chromosome engineering technology has been completed, and many state-of-the-art platforms are being constructed for drug discovery to combat intractable diseases. Through extensive use of these technologies, we will strive to reach out, even a day earlier, to patients who suffer from intractable diseases. ■Our Mission We contribute to people's living and health by applying innovative chromosome engineering technology developed by Tottori University (Japan) to medical treatment and drug discovering widely. ■Our Business: Research and development and commissioned research of pharmaceuticals by utilizing chromosome engineering technology - Development of humanized model mice & rats - Fully human antibody producing mice (TC-mAb mouse) - Humanized ADME model mice & rats (Tc-huADME Model) - Humanized genetic rare disease model mice & rats - Down Syndrome mouse/rat model (A model animal with human chromosome 21 introduced) - Contract studies - Discovery of fully human antibodies - Pharmacokinetic study using humanized ADME model mice & rats 　- Animal production of above trans-chromosomic mice & rats ____________________________________________________________________________ ■Our Key Technology: Artificial Chromosome Vector The artificial chromosome is a vector having a minimal function and structure as a chromosome by removing the gene region from a natural human or mouse chromosome. It is possible to introduce Mb size giant genes and multiple genes. The artificial chromosome is maintained stably in the cell and is transmitted from the parent to children in mouse and rat. The artificial chromosome vector is not inserted into the chromosome of the host but exists independently within the cell nucleus. Since it can carry various genes, it functions as a high-performance remote controller that issues commands to cells. Examples of practical applications include fully human antibody-producing animals, rare disease animal models, and cells / animals for functional evaluation. ■Fully Human Antibodies Producing Mouse: TC-mAb mouse We established a new generation of human Ab producing Tc mice (TC-mAb mice), which stably maintain a mouse-derived engineered chromosome containing the entire human Ig heavy and kappa chain loci in a mouse Ig knockout background. Comprehensive, high-throughput DNA sequencing revealed that the human Ig repertoire, including variable gene use, was well recapitulated in TC-mAb mice. Despite slightly altered B cell development and a delayed immune response, immunized TC-mAb mice exhibited more subsets of antigen-specific plasmablast and plasma cells compared with wild-type mice, leading to high efficiency hybridoma production. Thus, TC-mAb mice offer a valuable platform to obtain fully human therapeutic Abs and to elucidate the regulation of human Ig repertoire formation. [Contract studies] - Animal production of above trans-chromosomic mice & rats - Custom fully human antibody development using TC-mAb mouse. - We can refer you to our company’s partner. ■Humanized ADME Model Mouse & Rats: Tc-huADME Model In order to solve the problem of animal species differences found in research and development, human pharmacokinetic-related gene was introduced into experimental animals with artificial chromosome vector. Since it is introduced with gene regulatory region induced, it reproduces timing specific and tissue specific expressions in mouse / rat. These animals are useful for predicting human-specific pharmacokinetics, enzyme induction / inhibition tests, and analysis of drug-drug interactions. In addition to supplying animals as collaborative research, we also conduct contract tests from drug administration to sampling. - A model animal in which a pharmacokinetic-related gene cluster is humanized. - Physiological gene expression confirmed in all tissues. - Breeding by mating is possible. [TC-huADME model lines] - hCYP3A-Tc, mCyp3a KO(CYP3A5*3) mouse - hCYP3A-Tc, mCyp3a KO(CYP3A5*1) mouse - hCYP3A-Tc, rCyp3a KO rat - hCYP3A-Tc, mCyp3a KO, hPXR KI mouse - hUGT2-Tc, mUgt2 KO mouse / rat - hMDR1-Tc, mMdr1a/1b KO mouse [Contract pharmacokinetic (PK/TK) studies] In pharmacokinetic (PK/TK) study at our company's partner, temporal blood collection will be conducted after test substance is administered to the animal.Generally, plasma or serum will be separated and delivered in a frozen state. We can also collect urine and feces and dissect for tissue sampling. - Non-GLP study : Conducted by our company. - GLP study : We request our partner company (SHIN NIPPON BIOMEDICAL LABORATORIES, LTD. (SNBL)). ■HepG2 Cell for stable expression of 4CYPs+POR HepG2 cell: TC-HepG2 HepG2 cells, a cell line derived from human liver cancer, have been used as an alternative model of the liver for many years. However, since expression of drug metabolism-related genes (mainly CYP) is remarkably low, and it is considered difficult to use them as a substitute for human primary hepatocytes. We have overcome this problem with artificial chromosome vector connected to four CYPs (CYP2C9, CYP2C19, CYP2D6, CYP3A4) and POR and provide cells showing high CYP activity. [Applications of TC-HepG2 cell] - Inhibition test / drug interaction test - Research of hepatotoxicity - High content screening ■Down Syndrome mouse/rat model: Evaluation of anxiety-like behavior　 A model animal with human chromosome 21 introduced. The animal is useful for; - Phenotypic analysis of higher brain dysfunction etc. - Evaluation of drugs for ameliorating symptoms. - Drug discovery by identifying causative genes. - Drug repositioning search Please refer to the attached PDF for details.

Japan Tokyo, Tokyo JapanTriage Pharmaceuticals is the industry leading global biotechnology organization across the Best Service Ever categories, operating in over 50 facilitates operating in over 15 countries. Our expert team is passionate about our role in building comprehensive _world-class_ solutions that best enables Triage to improve and expedite your pipeline - with laser focus on customer service and delivering results. Our service portfolio includes the earliest stages of drug discovery through clinical trials, and our philosophy is to be a trusted partner with you and your organization to determine the optimal solutions based on your objectives and KPIs. We are the world's leading premier CRO, and fully accredited in a variety of scientific disciplines. Our expertise include: * Next Generation Sequencing * Human Biological Sample Provisioning and Analysis

3-8-3 Nihonbashi Honcho Chuo Ku, Tokyo, 1030023 JapanTriage Pharmaceuticals is the industry leading global biotechnology organization across the Best Service Ever categories, operating in over 50 facilitates operating in over 15 countries. Our expert team is passionate about our role in building comprehensive _world-class_ solutions that best enables Triage to improve and expedite your pipeline - with laser focus on customer service and delivering results. Our service portfolio includes the earliest stages of drug discovery through clinical trials, and our philosophy is to be a trusted partner with you and your organization to determine the optimal solutions based on your objectives and KPIs. We are the world's leading premier CRO, and fully accredited in a variety of scientific disciplines. Our expertise include: * Next Generation Sequencing * Human Biological Sample Provisioning and Analysis

Aoyama Place Canada 1F Place Canada,7-3-37 Akasaka, Minato-ku, Tokyo 107-0052, JapanAt Truven Health Analytics™, our purpose is to make healthcare better — lower costs, improved quality, better results. Simple words. Yet remarkably complex concepts. But that's not stopping us. Or our customers. Every day, we get to work with smart, passionate professionals, from every facet of the industry, as they manage change and implement strategies that will achieve exactly those outcomes. Our customers are healthcare payers and providers. In both the private and public sectors. They're researchers and suppliers. Regulators. Movers and shakers in each piece and part of the healthcare world. With this broad view of healthcare, we're able to see when new challenges are just beginning to emerge. And that's when we begin working on new solutions. Data. We're driven by it. Known for our exacting collection and secure management of data, we've worked with clinical evidence, claims, clinical, and other healthcare data for more than 40 years. We know the challenges to watch for, what to do about them — and how to recognize new ones. Like finding new ways to measure risk for providers who take on more of it, and payers who contract for it. Or integrating data to deliver the solutions today's converging healthcare interests demand. Analytics. Because data alone is just numbers and letters. The need for reliable insights from data demands proven analytics. Our methodologies and algorithms are uniformly trusted across the industry to deliver critical information that leads to confident decisions. Coupled with flexible reporting, integration, and consulting services, our sophisticated analytics enable our customers to make their part of healthcare better, faster. Domain expertise. We have it. We really have walked in our customers' shoes. We've worked in their environments. That level of understanding, plus our leading data management capabilities and advanced analytics, are why our customers turn to us as their partner to deliver quality, reduce costs, and yield greater value in healthcare.

Seavans North Bldg., 1-2-1, Shibaura, Minato-Ku, Tokyo 105-8449 JapanUbe Industries offers chemicals, plastics, pharmaceuticals, APIs, construction products and machinery.

67-2 Kashiwa, Kashiwa, Chiba 277-0005 JapanUnitech provides animal experiments, transgenic mice creation, recombination services, and genetic services.

Tsukuba-shi, Ibaraki-ken, 305-0006 Japan

Sanno Park Tower, Level 4 2-11-1 Nagata-cho, Chiyoda-ku Tokyo, Tokyo, 100-6104 JapanVista Health is a global value-based healthcare agency. We offer strategic consulting and tech-enabled solutions to our clients across all corners of healthcare, building lasting, meaningful partnerships with payers, providers, patients and industry players.

3-11-12, Hatchobori Daiki Bldg. 7F Chuo-Ku, Tokyo 104-0032 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

2-9 Kanda Nishikicho Chiyoda-ku, Tokyo 101-0054 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Nippon Building 6F, 2-6-2 Otemachi, Chiyoda-ku, Tokyo 100-0004 JapanWe offer contract research services ranging from data management and documentation support to statistical analysis and related application software development. We also dispatch researchers and developers to various institutions on a contract basis.

Tokyo, JAPAN 1410021Wholesale Group International (WGI) specializes in the supply of food technology and packaging product solutions. Through an associated business, (Total Scientific Solutions), WGI delivers nutritional, food technology and packaging consultancy to small, medium and multinational food manufacturers, and food distributors in Australia and also Japan. We specialize in the implementation of oxygen absorbers and an assortment of other absorbers (eg. CO2 releasing/ absorbing) in food products to extend shelf-life; Superior quality to traditional oxygen-absorbing satchel, reducing preservative use in food products. Our customers have specific quality assurance requirements (eg., WQA, BRC, ISO22000: HACCP, SQF2000) We can also assist in the selection of scientific testing and laboratory equipment for your food company in-house testing lab.

Selon Building 7F, 11-7 Shinsen-cho Shibuya-ku, Tokyo, 1500045 JapanDevelopment and management of the veterinary community website “Vetpeer” Providing product development, marketing, and sales support services to veterinary medical companies and organizations Offering comprehensive consulting services for development, market launch, and marketing to veterinary medical companies and organizations Development and management of information services for pet owners and livestock farmers Operation of a job placement service for veterinarians Sales of products for animal hospitals such as veterinary supplements, uniforms, and books Manufacturing and sales of medical devices for animals