95 Castle Hall Road Yemassee, SC, 29945 United StatesOverview: Alpha Genesis Inc. provides the highest quality nonhuman primate products and bio-research services world-wide. With a client base that extends across North America, Europe, and Asia, we are dedicated to providing only the best and most cost-effective primate research and development support to the scientific community. The Alpha Genesis Primate Research Center (AGPRC) is the designated Contract Research Organization (CRO) of Alpha Genesis Incorporated (AGI). The AGPRC research team is dedicated to fighting diseases ranging from Alzheimer’s to Zika and seeks to substantially improve human and animal health worldwide. In partnership with government organizations, private foundations, and private industry, AGPRC conducts studies seeking breakthrough discoveries of causes, preventions, treatments and cures. The highly regulated study of nonhuman primates (NHPs) is critically important, as it often precedes clinical trials in humans and cannot be replicated any other way. Primate Research Resources: The Alpha Genesis Primate Research Center is a full-service AAALAC-accredited facility that provides ready access to several thousand macaque primates maintained in our U.S. based facilities. Our domestic SPF primate breeding colonies are unique within the industry and have been used in a wide variety of research applications across all stages of primate development, from pre-natal through juvenile, adolescent, adult, and geriatric. Primate Research Capabilities: The Alpha Genesis Primate Research Center offers an extensive array of contract research capabilities from early discovery and proof-of-concept to developmental toxicology. Research areas include pharmacokinetics, compound screening, vaccine testing, efficacy assessment, pharmacology, and early lead optimization. The Center is a full-service facility that provides primate quarantine, colony maintenance, colony support, primate biological products, and on site use. Alpha Genesis - Your Primate Center of Excellence: Alpha Genesis has helped its customers conduct research projects with nonhuman primates for nearly two decades. When you conduct your research at Alpha Genesis our team will work directly with you to develop your research concept and study design in a cost-efficient and timely manner. Because we conduct our research, and maintain a large inventory of research primates, on site at our AAALAC-accredited facilities located within the U.S. you are guaranteed personalized attention from your own Alpha Genesis Research Advisor and a quick study start. Research areas routinely include: Cardiovascular studies Ocular toxicology Neurotoxicology Bone toxicology Developmental and Reproductive Toxicology (DART) Drug addiction and prevention Digestive processes Human Immunodeficiency Virus (HIV) Body composition Continuous infusion Geriatric models Pharmacokinetics (PK) Vaccine development and testing For further information please email us at info@alphagenesisinc.com

4221 Faber Place Drive, Charleston, South Carolina 29405Alcami offers analytical and formulation services, clinical packaging and distribution, contract manufacturing services and oral drug delivery technologies. It also offers chemical development, salt and polymorph screening, scale up and API manufacturing, including highly potent materials.

1024 Dittman Crt North Augusta, SC, 29842 United StatesAmbioPharm, Inc. (APi) is a full-service peptide manufacturing company headquartered at our North Augusta, South Carolina, USA cGMP production site. Our second cGMP facility in Shanghai, China, performs process development & optimization, and manufactures building blocks, raw materials, and custom peptides at very large scale. Both our cGMP facilities are capable of handling any manufacturing scale required to produce bulk peptides to custom specifications using a wide range of skill sets in both solid and solution-phase chemistry. Our management team has well over 100 years cumulative experience running pilot to commercial scale production. We also perform organic conjugations to small molecules, proteins, toxoids, antifungals, KLH, and PEG.

1024 Dittman Court North Augusta SC 29842AmbioPharm, Inc. (APi) is a full-service peptide manufacturing company headquartered at our North Augusta, South Carolina, USA cGMP production site. Our second cGMP facility in Shanghai, China, performs process development & optimization, and manufactures building blocks, raw materials, and custom peptides at very large scale. Both our cGMP facilities are capable of handling any manufacturing scale required to produce bulk peptides to custom specifications using a wide range of skill sets in both solid and solution-phase chemistry. Our management team has well over 100 years cumulative experience running pilot to commercial scale production. We also perform organic conjugations to small molecules, proteins, toxoids, antifungals, KLH, and PEG.

PO Box 1275 Ladson, SC 29456 USABioAbChem offers recombinant proteins, natural proteins, antibodies, and lab consumables.

13000-F York Highway Charlotte NC 28278Bioskin offers clinical trials, consulting, data management, transdermals, and in vivo testing.

Clemson University, Clemson, SC 29634The Godley-Snell Research Center (GSRC) opened on Clemson University campus in August of 1995 as a centralized animal research facility. GSRC has 22,000 sq. ft. dedicated to maintaining a variety of laboratory animal species used in research and teaching programs at Clemson University; and to providing resources and support services for those programs. GSRC is managed by the Office of Research Services and provides facilities, equipment, caging, and veterinary and technical support to facilitate animal research and teaching programs. GSRC has housing space for large and small laboratory animals, including two suites of individually ventilated isolation cubicles. Facilities and caging are available for housing laboratory rodents, rabbits, chickens, goats, swine, and other species as required. Ventilated cage rack systems and micro isolator cages are available for housing mice. All animal rooms have centrally controlled temperature, humidity, air-flow, pressure differentials, and lighting. Environmental parameters are monitored continuously using a computer controlled monitoring system with dial out alarms. Laboratory animals are procured from pre-approved sources of specific pathogen free animals. Research Services staff includes laboratory animal trained veterinarians and animal care technicians. Animal care staff provides seven day a week animal care and health surveillance. The surgical facility has two large operating rooms, nursing station, sterile prep, recovery room, procedure and surgical prep room, and radiology. Anesthetic delivery and monitoring equipment are available for various animal species. GSRC maintains a biocontainment suite that meets CDC, Animal Biosafety Level 3 criteria. Access to the facility is controlled by an electronic card access system. The suite contains 1000 sq. ft. animal housing space, a controlled environment chamber, laboratory space, and personnel shower/locker. Laboratory equipment includes a Class II B2 biosafety cabinet and a pass-through steam sterilizer. The biocontainment area is maintained under negative pressure differential with 100% fresh air and 100% HEPA filtered exhaust. Animals are maintained in accordance with all animal welfare regulations and federal guidelines to ensure humane care. Clemson University animal research facilities and programs are registered by USDA and have received full accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC).

Clemson, SC 29634A microscopy facility, located on the 3 rd floor of Jordan Hall, houses a number of microscopes for use by researchers. These include a Zeiss Axiovert 135 Fluorescence microscope with green, red and DAPI fluorescence capabilities, a Zeiss Axiovert 25 inverted light microscopy, and a Nikon SMZ800 stereomicroscope. All microscopes are equipped for digital image capture.

Clemson, SC 29634Computer-controlled Cepheid SmartCycler PCR instrumentation is available to perform real-time PCR.

580 East Main Street Spartanburg, SC 29302Since 1889, Converse has been igniting the voices of students through education that prepares them “to see clearly, decide wisely and act justly.” Our women’s college and our graduate programs for men and women launch passionate global citizens whose energy, creativity and competence bring value to their professions and their communities.

Columbia, SC United StatesClinical List America has a nationwide, proprietary medical database that is verified as 100 percent HIPAA compliant.

P.O. Box 6331 Columbia, SC 29260Clinical List America has a nationwide, proprietary medical database that is verified as 100 percent HIPAA compliant.

436 West Palmetto Street, Florence, SC 29501-7124

66 George Street Charleston, SC, 29424 United States

66 George Street Charleston, SC 29424 USA

Clemson University Electron Microscope Facility Clemson Research Park AMRL Building 91 Technology Drive Anderson, SC 29625

Clemson, SC 29634The CUGI BAC/EST Resource Center produces high quality BAC libraries, cDNA libraries, and various types of shotgun libraries. The facility works with plant, animal and microbial genomes. At the present time, CUGI has one of the largest collections of BAC libraries in the world. CUGI also provides fee-based services for robotics (colony picking, re-arraying, colony filter arrays, library storage and clone distribution), sequencing (cDNA, shotgun, BAC-end), physical mapping (BAC fingerprinting, marker hybridization), proteomics and lipidomics (mass spectroscopy, modification, hydrophobicity and shotgun proteomics), and functional genomics (labeling and hybridization, chip reading and statistical analyses).

Clemson, SC 29634Reptile/Amphibian vivarium. 6 x 4 m greenhouse room with floor drain on the roof of Jordan Hall managed by the Biomechanics Lab (R. Blob, PI). Suitable for housing aquatic or terrestrial vertebrates that prefer warm temperatures, including reptiles and many amphibian and fish species.

Clemson, SC 29634This Facility provides histological services for tissue processing, paraffin embedding and sectioning, frozen tissue embedding and sectioning, routine staining and immuno-histochemical detection of antigens. Two electron microscopes and associated equipment for sampler preparation are associated with this Facility. One technician operates the facility.

171 Old Cherry Road, Clemson, SC 29634The Agricultural Service Laboratory provides a variety of analytical agricultural testing. Samples may be submitted through the County Extension Offices or directly to the lab. Each County Extension Office has the supplies needed for submitting samples. Information For: Field and Truck Crops Nursery Growers Home Lawn & Gardens Turfgrasses Livestock Farmers Christmas Trees

66 George Street Charleston, SC 29424 USAThe Grice Marine Laboratory is the marine lab of the College of Charleston and houses academic programs in Marine Biology. The lab supports teaching and research in evolutionary biology, marine biogeography, cellular and molecular biology, benthic ecology, immunology, microbial ecology, phytoplankton ecology, environmental physiology, fish systematics, and invertebrate zoology and other marine sciences. The laboratory is located at Fort Johnson on James Island, South Carolina.

Anderson, SC United StatesCustom Synthesis offers custom synthesis services and supplies specialty chemicals.

1704 Denver Road Anderson, SC 29625 USACustom Synthesis offers custom synthesis services and supplies specialty chemicals.

Clemson, SC 29634Computer-controlled Bio-Tek spectrophotometer (μQuant) and fluorimeter (FLX-800) plate readers are available for spectroscopy needs. In addition, a luminometer has been provided by Turner Biosystems through their grant program.

Clemson, SC, USAThe Clemson University Plant Problem Clinic is a multidisciplinary program which provides diagnoses and management recommendations for plant problems, which include diseases, nematodes, weeds, and insect pests of plants. We also identify insects infesting structures, humans, pets and livestock. The Clinic receives most of its samples from the county Extension offices, and works closely with Clemson University Specialists to provide management recommendations. As a part of Clemson University Regulatory Services, we also help to detect and document new plant diseases and pests in South Carolina.

2260A Peach Orchard Road Sumter, SC 29154 USACustom Analytics offers LC, GC, MS, FTIR, and microbiology services.

1156 Bowman Rd. Mt. Pleasant, SC 29464 USACoastal Carolina Research Center offers clinical research services.

Clemson, SC 29634This facility houses a Zeiss LSM510 with optics for red and green fluorescence, and imaging software for additional image analysis and manipulation.

Greenwood, SC, USACapsugel provides, dosage form development, powder formulation, capsule gels, and filling equipment.

1023 Wappoo Rd Suite 43B Charleston, SC, 29407 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

State Road 496 Union, SC, 29379 United States

1400 caliper oak cir #314 MOUNT PLEASANT , Sc, 29464 United StatesWe combine phd-level scientific knowledge with professional graphic arts design to produce eye-catching self-explanatory scientific images for articles, presentations, proposals, books and much more.

3300 Poinsett Highway Greenville, South Carolina, 29613Our department is located in the Charles H. Townes Science Center. Dedicated in 2008, this $62.5 million facility houses all of the science departments at Furman. You'll find cutting-edge research happening throughout this 200,000-square foot building.

 As a biology student, you'll have the opportunity to work with state-of-the-art equipment in a modern facility. Our space features a number of areas for specialized instruction and undergraduate research: A large greenhouse adjacent to the Townes Science Center that is equipped with a tidal wetland aquatic waste water treatment system A molecular assays core facility with darkroom, that provides instrumentation and expertise to faculty and students in several departments. Aquatic biology laboratory with temperature-controlled aquaria and an indoor stream Controlled-environment laboratory with eight reach-in environmental chambers. An herbarium with more than 20,000 catalogued plant specimens A 1,354 sq. ft. animal facility, overseen by a three faculty and a consulting veterinarian in accordance with the DHHS requirements and approved by the Office of Laboratory Animal Welfare of the NIH. Separate, dedicated rooms for flourescence microscopy and radiosotope work A walk-in cold room Areas for individual and group study Lab space for each of our faculty members

South Carolina 413 Iva, SC, 29655 United StatesThe Biosample Repository Facility (BRF) coordinates the ethical collection, storage, annotation and distribution of human biosamples and associated comprehensive patient and family cancer history data, clinical interventions and lifestyle factors under an Institutional Review Board-approved protocol. We adhere to the International Society for Biological and Environmental Repositories and National Cancer Institute Best Practices for Biospecimen Resources and participate in the NCI Office of Biorepositories and Biospecimen Resources and Biospecimen Research Network. BRF expediates bidirectional flow from lab bench to clinic, and stimulates translational research associated with clinical trials and basic research. We provide tissue-based research services—including tissue microarray construction and immunohistochemistry, automated tissue image analysis and electrochemiluminescent enzyme-linked immunosorbent assay-based biomarker analysis—to support translational and basic research.

4361 Charlotte Highway Lake Wylie, SC, 29710 United States

Charleston, SC, USAGEL Analytics provides impurity identification, degradation studies, and analytical services.

600 Seacoast Parkway Mount Pleasant, South Carolina 29464 USAGenPhar provides biodefense, prophylactic and therapeutic vaccines for the world’s most dangerous viral diseases.

SC United StatesThe ITOR Biorepository Services Department – in conjunction with the Greenville Health System’s surgical oncologists, pathologists and staff – have developed tissue bank sample processing guidelines for frozen tissue, fresh tissue and peripheral blood and include flash freezing in liquid nitrogen within 15 minutes of harvest to maximize cell viability for basic science research. The department has a dedicated staff, including three research nurses and a data coordinator, which facilitate the logistics of tissue handling and submit outcomes data on participating patients. The ITOR Biorepository staff has adopted a universal consent for all patients of the Greenville Health System to have the option of donating excess tissue for research, should they desire. ITOR of GHS has several tissue-based patient initiatives & programs under development and ongoing.

Charleston, SC, USAGEL Laboratories environmental lab services, chemical analysis, and radiochemistry

101 East Wood Street Spartanburg, SC, 29303 United StatesGuardian Research Network is a non-profit, mission-driven consortium that has partnered with community health systems throughout the US to create a centralized longitudinal database of electronic medical record (EMR) data. GRN has developed proprietary query technology and natural language processing (NLP) tools that allow our system to "read" the charts to create customized cohorts of patients for real-world evidence (RWE) analysis, archival specimen collection, and prospective trial/registry matching. GRN's network members treat over 40 million lives. with access to complete medical records - including progress notes, outcomes results, medication history, lab/test results from oncology AND non-oncology encounters within the health system - GRN creates comprehensive HIPPA-compliant datasets that give our customers invaluable insights into health care practices and health outcome. We’ve since grown, impacting and partnering to provide: 1. Health Systems with integrated, harmonized data, refined analytics and precision medicine opportunities using our sophisticated technology. 2. Life Science organizations with clinical development speed and efficiency through discrete trial matches, diagnostic and therapeutic, while empowering clinical researchers with both molecular and clinical specimens 3. Patient access to innovative, targeted and novel therapies via high performing investigational community hospitals

1313-B Ashley River Road Charleston, SC 29407Guild BioSciences provides protein analysis, purification, and profiling services.

Charleston, SC United StatesGuild BioSciences provides protein analysis, purification, and profiling services.

105 A Regency Blvd., Greenville, NC 27834 USAH & A Scientific develops quality software and hardware products for the needs of pharmaceutical and medical device companies.

1100 Dittman Court Beech Island, SC 29842 USAHalocarbon manufactures aliphatic fluorochemicals, inert oils, greases and waxes and inhalation anesthetics and other specialty fluorochemicals.

Beech Island, SC, 29842 United StatesHalocarbon manufactures aliphatic fluorochemicals, inert oils, greases and waxes and inhalation anesthetics and other specialty fluorochemicals.

101 Technology Place Florence SC 29501 USAIrix Pharmaceuticals provides custom raw materials, synthons, standards, discovery support, process development, and manufacturing.

101 Technology Place Florence, SC, 29501 United StatesIrix Pharmaceuticals provides custom raw materials, synthons, standards, discovery support, process development, and manufacturing.

900 West Faris Road, 3rd Floor Greenville, SC 29605 USAInstitute for Translational Oncology Research (ITOR) offers clinical trial and biorepository services.

Greenville, SC United StatesInstitute for Translational Oncology Research (ITOR) offers clinical trial and biorepository services.

730 Columbia Hwy N Estill, SC, 29918 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

110 Centrum Dr. Irmo, SC, 29063 United StatesIMCS designs develops, manufactures, and distributes next-generation recombinant proteins and chromatography consumables to clinical and forensic toxicology, academic research facilities, US Federal Government agencies, and health science companies in North America, Europe, and Asia.  The company has two product lines: IMCSzyme® and IMCStips®. The industry-disrupting IMCSzyme is a genetically modified enzyme primarily used by clinical, forensic, and pain care laboratories for the drug screening and analysis of urine and other biological samples. IMCStips are advanced micro-chromatrography products centered around patented dispersive solid-phase extraction (dSPE) technology that contain loosely packed resin for faster biochemical purification processes. IMCStips are utilized by academic laboratories and health science companies for purifying new proteins, antibodies and enzymes, as part of drug target discovery and validation, drug development, drug screening, and drug manufacturing.  Recently, IMCS was awarded NIH SBIR funds to manufacture various glycosyltransferases to leverage its advanced manufacturing and research capabilities to expand synthesis of glycosphingolipids and sialoglycans. This expansion provides IMCS with new product lines and enables it to manufacture affordable, critically needed biological reagents that were not previously available to the scientific community.

119 Anderson HallKansas State University Integrated Genomics Facility provides high throughput screening, DNA and RNA quality control, microarray, and sequencing services.

2. North Main Street Greenville, SC, 29601 United StatesKiyatec specializes in providing advanced, 3D cell-based assays and diagnostics with superior physiologic relevance for more accurate ex vivo prediction of patient response to drugs. Kiyatec’s Greenville, South Carolina offices and labs are located in the heart of downtown, and closely collaborate with the Institute for Translational Oncology Research (ITOR) Clinical Research Unit on the main campus of the Greenville Health System, the 13th largest public hospital system in the United States. Kiyatec utilizes primary sourced cells and tissues directly from patients, to provide valuable data and insight to meet the needs of the pharmaceutical, biotechnology and healthcare industries. This information is becoming more vital, as Kiyatec is working to close the translational gap from preclinical to clinical by utilizing immunoassays, imaging, and other analytical capabilities on careful designed, proprietary spheroids. Kiyatec is continuing to develop robust phenotypic cell-based cancer diagnostics using viable tumor biopsies to assess patient-specific response to available therapeutic agents. By leveraging Kiyatec’s specialized expertise and clinical connectivity, we add significant value to our clients’ preclinical, adaptive or co-clinical trials, and post-approval small molecule and biologic programs. Our technologies and methods provide more accurate simulation of phenomenon inherent within the living systems of the human body. Accurate modeling of these dynamic conditions creates opportunity for enhanced diagnostics and advanced medical treatments that will benefit society through the resulting improvements in healthcare and its associated costs.

2. North Main Street Greenville, SC, 29601 United StatesKiyatec specializes in providing advanced, 3D cell-based assays and diagnostics with superior physiologic relevance for more accurate ex vivo prediction of patient response to drugs. Kiyatec’s Greenville, South Carolina offices and labs are located in the heart of downtown, and closely collaborate with the Institute for Translational Oncology Research (ITOR) Clinical Research Unit on the main campus of the Greenville Health System, the 13th largest public hospital system in the United States. Kiyatec utilizes primary sourced cells and tissues directly from patients, to provide valuable data and insight to meet the needs of the pharmaceutical, biotechnology and healthcare industries. This information is becoming more vital, as Kiyatec is working to close the translational gap from preclinical to clinical by utilizing immunoassays, imaging, and other analytical capabilities on careful designed, proprietary spheroids. Kiyatec is continuing to develop robust phenotypic cell-based cancer diagnostics using viable tumor biopsies to assess patient-specific response to available therapeutic agents. By leveraging Kiyatec’s specialized expertise and clinical connectivity, we add significant value to our clients’ preclinical, adaptive or co-clinical trials, and post-approval small molecule and biologic programs. Our technologies and methods provide more accurate simulation of phenomenon inherent within the living systems of the human body. Accurate modeling of these dynamic conditions creates opportunity for enhanced diagnostics and advanced medical treatments that will benefit society through the resulting improvements in healthcare and its associated costs.

900-B West Faris RoadKiyatec specializes in providing advanced, 3D cell-based assays and diagnostics with superior physiologic relevance for more accurate ex vivo prediction of patient response to drugs. Kiyatec’s Greenville, South Carolina offices and labs are located in the heart of downtown, and closely collaborate with the Institute for Translational Oncology Research (ITOR) Clinical Research Unit on the main campus of the Greenville Health System, the 13th largest public hospital system in the United States. Kiyatec utilizes primary sourced cells and tissues directly from patients, to provide valuable data and insight to meet the needs of the pharmaceutical, biotechnology and healthcare industries. This information is becoming more vital, as Kiyatec is working to close the translational gap from preclinical to clinical by utilizing immunoassays, imaging, and other analytical capabilities on careful designed, proprietary spheroids. Kiyatec is continuing to develop robust phenotypic cell-based cancer diagnostics using viable tumor biopsies to assess patient-specific response to available therapeutic agents. By leveraging Kiyatec’s specialized expertise and clinical connectivity, we add significant value to our clients’ preclinical, adaptive or co-clinical trials, and post-approval small molecule and biologic programs. Our technologies and methods provide more accurate simulation of phenomenon inherent within the living systems of the human body. Accurate modeling of these dynamic conditions creates opportunity for enhanced diagnostics and advanced medical treatments that will benefit society through the resulting improvements in healthcare and its associated costs.

900-B West Faris Road Greenville, SC, 29605 United StatesKiyatec specializes in providing advanced, 3D cell-based assays and diagnostics with superior physiologic relevance for more accurate ex vivo prediction of patient response to drugs. Kiyatec’s Greenville, South Carolina offices and labs are located in the heart of downtown, and closely collaborate with the Institute for Translational Oncology Research (ITOR) Clinical Research Unit on the main campus of the Greenville Health System, the 13th largest public hospital system in the United States. Kiyatec utilizes primary sourced cells and tissues directly from patients, to provide valuable data and insight to meet the needs of the pharmaceutical, biotechnology and healthcare industries. This information is becoming more vital, as Kiyatec is working to close the translational gap from preclinical to clinical by utilizing immunoassays, imaging, and other analytical capabilities on careful designed, proprietary spheroids. Kiyatec is continuing to develop robust phenotypic cell-based cancer diagnostics using viable tumor biopsies to assess patient-specific response to available therapeutic agents. By leveraging Kiyatec’s specialized expertise and clinical connectivity, we add significant value to our clients’ preclinical, adaptive or co-clinical trials, and post-approval small molecule and biologic programs. Our technologies and methods provide more accurate simulation of phenomenon inherent within the living systems of the human body. Accurate modeling of these dynamic conditions creates opportunity for enhanced diagnostics and advanced medical treatments that will benefit society through the resulting improvements in healthcare and its associated costs.

411 University Ridge Suite A Greenville, SC 29601 USALab21 is a specialist diagnostic company offering fully accredited clinical trial support services and a full range of product and Companion Diagnostics development, manufacture and commercialisation capabilities.

173 Ashley Avenue Building CRI Room 505c Charleston, SC, 29425 United StatesMUSC Lipidomics Shared Resource The Lipidomics Shared Resource at MUSC represents expertise specializing in sphingolipid biology, providing services to the Medical University of South Carolina and institutions or industries throughout the world. The Lipidomics Shared Resource is composed of analytical and synthetic units providing expertise, synthetic compounds/standards, and analytical methodology (LC-MS/MS and SFC-MS/MS) to enhance an understanding of the role of bioactive lipids in disease pathology. Overview: The Lipidomics Shared Resource builds on the unique expertise of key personnel in sphingolipid chemistry, analysis, and biology providing intellectual and physical resources to enhance the understanding of bioactive sphingolipids and lipids in signal transduction and cell regulation. Sphingolipids are recognized as key components regulating fundamental cell biology processes regulating transmembrane signaling. Diversity of bioactive sphingolipids and their interconnected metabolism provide a network of pathways. Key sphingolipid metabolites are: ceramides (Cer), sphingosine (Sph), sphingosine 1-phosphate (S1P), and ceramide 1-phosphate (Cer1P). Services & Expertise: The Lipidomics Shared Resource is designed to support research in lipidomics by providing advanced methodology and expertise for both synthesis and analysis of bioactive lipids in a cost-effective manner, with a focus on several key areas: - Providing qualitative and quantitative analysis of >300 sphingolipids using high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) technologies. - Providing analytical method development of new lipid components. - Providing and developing synthetic lipid tools/standards, including functionalized and fluorescent ceramides, 17C-sphingolipids; or synthetic lipid analogs, including organelle-targeted sphingolipids. - Mentoring investigators in the understanding of lipid biology through lipid chemistry, experimental design, selection of lipids of interest, and interpretation of the analytical data. Services: The Analytical Unit provides sample preparation/lipid extraction, data normalization measurements (levels of inorganic phosphate/sample), and lipid analysis based on High-Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) or Supercritical Fluid Chromatography-tandem Mass Spectrometry (SFC-MS/MS) approaches. The core provides both qualitative (compound identification) and quantitative mass spectral analysis of key lipids from various biological materials (cells, tissues, serum, blood, etc) with assays to measure over 300 different sphingolipid, DAG components, and Free Fatty Acids at a basic metabolic level. Analytical Units: 1. Sph/S1P/Cer Sphingoid bases (Sphingosine [Sph]& Dihydro-Sphingosine [dhSph]) Sphingoid base-1- Phosphates (S1P & dhS1P), Ceramide molecular species (Cn-Cer) This is the most basic analysis, covering 18 different molecular species 2. dhCer Dihydro-Ceramide molecular species 3. Hexosyl-Cer Hexosylceramide (Glucosyl/Galactosyl-Ceramide) molecular species 4. Lactosyl-Cer Lactosyl-Ceramide molecular species 5. SM Sphingomyelin molecular species 6. DAG Diacyl-Glycerol molecular species 7. α-OH-Cers (2’OH-Cer) Alpha-Hydroxy-Ceramide molecular species 8. Cer-1P Ceramide 1-Phosphate molecular species 9. PhytoSph/PhytoCer Phytosphinghosine, Phytosphingosine-1-Phosphate and Phytoceramide molecular species 10. α-OH-PhytoCer Alpha-Hydroxy-Phytoceramide molecular species 11. 17CSph/S1P/Cer 17C-Sphingoid bases, 17C-Sphingoid base-1- Phosphates and 17C-Ceramide molecular species 12. dh17CSph/S1P/Cer 17C-Dihydro-Sphingoid bases, 17C-Dihydro-Sphingoid base-1- Phosphates and 17C-Dihydro-Ceramide molecular species 13. Glu/Gal-Cer by SFC Glucosylceramide and Galactosylceramide species separated by SFC-MS/MS 14. 1-Deoxy-Sph/Cer 1-Deoxy-Sphingoid bases, 1-Deoxy-Ceramide molecular species 15. 1-Deoxy-dhCer 1-Deoxy-dihydro-Ceramide molecular species 16. Free Fatty Acids FFA molecular species C12- to C26- saturated and monounsaturated species 17. Special Request available upon consultation Analytical Approach: Quantitative analyses of sphingolipids, are based on eight-point calibration curves generated for each target analyte. The synthetic standards along with a set of internal standards are spiked into an artificial matrix, they are then subjected to an identical extraction procedure as the biological samples. These extracted standards are then analyzed by the HPLC/MS/MS or SFC/MS/MS system operating in positive multiple reaction-monitoring (MRM) mode employing a gradient elution. Plotting the analyte/internal standard peak area ratios against analyte concentrations generates the analyte specific calibration curves. Any lipid with no authentic standards is quantitated using the calibration curve of its closest counterpart. Publication Acknowledgement: “Supported in part by the Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313 and P30 GM103339)”.

280 VANCE ROADMidwest Scientific provides research tools, products, kits, and equipment.

171 Ashley AvenueMedical University of South Carolina Proteogenomics Facility offers surface plasmon resonance, DNA array, and bioinformatics services.

Charleston, SC United StatesMedical University of South Carolina Proteogenomics Facility offers surface plasmon resonance, DNA array, and bioinformatics services.

3471 River Hills DriveMeridian Life Science provides antibody and antigen production, assay development, process development, and cGMP manufacturing.

15 North Kings Road, Greenville, SC 29605New Life Chemical offers chemicals for purchase.

Greenville, SC United StatesNew Life Chemical offers chemicals for purchase.

65 Society StreetNCGS Laboratories offers clinical phase I to phase IV research services such as regulatory, quality assurance, clinical data management, and investigator recruitment.

Charleston, SC United StatesNCGS Laboratories offers clinical phase I to phase IV research services such as regulatory, quality assurance, clinical data management, and investigator recruitment.

S.C.F. 60 IInd Floor,NanoBio Services is a contract pharmaceutical manufacturer that provides pharmaceutical and bioservices.

530 Fairview Avenue NOur Mission is to Map the Universe of Biology. Improving the human condition is what fuels our passion for finding new ways of enabling scientific exploration. As a company, we strive to create end-to-end solutions that are simpler, easier, faster and more relevant to today’s life science challenges. As the pioneer in the field of spatial biology, NanoString enables scientists across the globe to envision molecular interactions in three dimensions with three different systems, the nCounter® Analysis System, the GeoMx® Digital Spatial Profiler (DSP) and the CosMx™ Spatial Molecular Imager (SMI) platform. As a result, scientists can see the multiomic expression of genes and proteins in the natural context of tissue structure. Since our founding in 2003, we have earned a reputation as a respected, trusted pioneer of innovative technologies that support our customers in their relentless pursuit of answers. Our products are based on a novel digital molecular barcoding technology invented at the Institute for Systems Biology (ISB) in Seattle under the direction of Dr. Leroy Hood. In 2008, we launched the nCounter Analysis System and began international sales operations with its first multiplexed assays for gene expression analysis. Since commercial launch, the nCounter platform has been cited in more than 4,600 peer-reviewed publications. Our first spatial platform, GeoMx DSP, was launched in 2019, enabling highly multiplexed spatial profiling of RNA and protein targets in various sample types, including challenging Formalin-Fixed, Paraffin-Embedded (FFPE) tissue. The unique combination of high-plex and high-throughput spatial profiling allows researchers to rapidly and quantitatively assess the biological implications of heterogeneity within tissues and has resulted in over 60 peer-reviewed publications to date. Continued investment in innovation has produced a robust product pipeline including the Spatial Molecular Imager that will provide highly sensitive, sub-cellular imaging of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact tissue samples. This new platform complements the high-plex, high throughput GeoMx DSP and together, these platforms will span the continuum of spatial biology applications and will serve the needs of both discovery and translational researchers. With our technologies, our customers continue to extend our understanding of biology to answer previously unsolvable questions with consistent, reliable results. However, NanoString is much more than innovative products. The secret sauce to the company’s success is our people, who are committed to excellence and dedicated to catalyzing the next biological revolution. Collectively, we live our corporate values of ambition, grit, ingenuity, authenticity, and customers every day…and never stop asking “What if?” Follow us on LinkedIn: @NanoString Technologies, Inc. Follow us on X/Twitter: @@nanostringtech Like us on Facebook: @NanoStringTechnologies Subscribe to our YouTube channel: @NanoStringTech

1741 Old Dunbar Road West Columbia SC 29172 USAOakwood Products provides custom organic synthesis services.

West Columbia, SC, 29169 United StatesOakwood Products provides custom organic synthesis services.

104 Berkeley Square LanePRN Pharmaceutical Research Network offers phase IV clinical research studies as well as study design, site selection, site monitoring, data management and corporate financing.

7001 St. Andrews Rd. Suite 333 Columbia, SC 29212 USAProHisto supplies primary and secondary antibodies in addition to buffers, kits, and counterstains in application of immunohistochemistry and immunofluorescence.

52 Technology Drive Anderson, SC 29625Poly-Med provides biomedical polymeric materials for medical applications, consulting services and contract manufacturing.

51 Technology Drive Anderson, SC 29625 USAPoly-Med provides biomedical polymeric materials for medical applications, consulting services and contract manufacturing.

900b West Faris Road Greenville, SC, 29605 United StatesPurilogics is a leading developer of high performance membrane adsorbers for biologics purification. We provide Purexa™ series of membrane adsorber products, including Protein A membrane, mRNA affinity membrane, weak anion-exchange membrane, and multimodal anion-exchange membrane, hydrophobic interaction chromatography membrane, and other affinity membrane. Compared to resin based columns, Purexa™ membrane products enable purification at much faster speed.

221 Cooper Lane Easley, SC, 29642 United StatesParimer Scientific is a Contract Development and Manufacturing Organization (CDMO) that specializes in the development of small-molecule drugs. Located in South Carolina USA, Parimer provides support to its clients for API development from the developmental phase through clinical trials and into kilo-scale cGMP production. Parimer is particularly adept at supporting new chemical entities (NCEs) and unique chemical challenges. As a small company ourselves, we offer unmatched agility and drive. Despite being founded as recently as 2018, Parimer has already grown to support over 30 emerging biotechnology companies. When you partner with Parimer, you will have access to the cell phone numbers of the owner of the company and your project manager, so you can call them anytime. Parimer operates as an extension of your operations, meaning that it becomes a part of your company where employees may be viewed as 1099 contractors.

Mount Pleasant, SC United StatesRyan Scientific provides and distributes chemical compounds from various vendors for purchase.

109 Bee Street Charleston, SC 29401The Ralph H. Johnson VA Medical Center, opened in 1966, consists of one primary, secondary, and tertiary care facility located in Charleston, SC, serving over 67,000 Veterans in 21 counties, encompassing more than 15,000 square miles. Charleston VAMC is a 149 authorized bed tertiary care teaching hospital with 20 operating nursing home care beds, and is dedicated to providing the highest quality of patient care and services to Veterans along the South Carolina and Georgia coasts. The full range of inpatient and outpatient care is provided including Medical and Surgical Intensive Care, and Medical/Surgical. The Ralph H. Johnson VA Medical Center provides comprehensive health care through primary care, tertiary care, and long-term care in areas of medicine, surgery, psychiatry, physical medicine and rehabilitation, neurology, women's health and dentistry. Specialty services include Cardiothoracic Surgery, Neurosurgery, Orthopedics, Mental Health programs for PTSD, Substance Use Disorders, Military Sexual Trauma, Cardiology, Oncology, Nephrology, Pulmonary and Geriatrics. The VAMC includes five Community Based Outpatient Clinics (CBOC) located in Beaufort, Goose Creek and Myrtle Beach, South Carolina, and Savannah and Hinesville, Georgia, as well as an annex in North Charleston. The Ralph H. Johnson VA Medical Center also supports three Vet Centers located in Charleston and Myrtle Beach, South Carolina, and Savannah, Georgia.

109 Bee Street Charleston, SC, 29401 United StatesThe Ralph H. Johnson VA Medical Center, opened in 1966, consists of one primary, secondary, and tertiary care facility located in Charleston, SC, serving over 67,000 Veterans in 21 counties, encompassing more than 15,000 square miles. Charleston VAMC is a 149 authorized bed tertiary care teaching hospital with 20 operating nursing home care beds, and is dedicated to providing the highest quality of patient care and services to Veterans along the South Carolina and Georgia coasts. The full range of inpatient and outpatient care is provided including Medical and Surgical Intensive Care, and Medical/Surgical. The Ralph H. Johnson VA Medical Center provides comprehensive health care through primary care, tertiary care, and long-term care in areas of medicine, surgery, psychiatry, physical medicine and rehabilitation, neurology, women's health and dentistry. Specialty services include Cardiothoracic Surgery, Neurosurgery, Orthopedics, Mental Health programs for PTSD, Substance Use Disorders, Military Sexual Trauma, Cardiology, Oncology, Nephrology, Pulmonary and Geriatrics. The VAMC includes five Community Based Outpatient Clinics (CBOC) located in Beaufort, Goose Creek and Myrtle Beach, South Carolina, and Savannah and Hinesville, Georgia, as well as an annex in North Charleston. The Ralph H. Johnson VA Medical Center also supports three Vet Centers located in Charleston and Myrtle Beach, South Carolina, and Savannah, Georgia.

1657 East Greenville StreetRadiant Research offers phase I-IV clinical research services including project management, quality assurance, biostatistics, and clinical monitoring with expertise in dermatology, endocrinology, infectious disease, and metabolism.

411 University Ridge, Suite A Greenville, SC 29601 USASelah Genomics is a clinical diagnostic specialist supporting healthcare providers and the pharmaceutical industry with advanced molecular and genomic diagnostic services.

101 East Wood Street Spartanburg, SC 29303

421 Chalk Bed Road Graniteville, SC, 29829 United StatesThe Hollings Cancer Center (HCC) Biorepository & Tissue Analysis (BTA) Shared Resource provides investigators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource comprises several integrated components, e.g., biospecimen and data repository, customized and readily available tissue microarrays (TMAs), laser capture microdissection (LCM), matrix-assisted laser desorption/ionization (MALDI) tissue imaging, and research pathology services such as histologic analysis of fixed, frozen, and stained tissues and analysis of experimental results.

110 Walnut Lane North Augusta, SC, 29860 United StatesWe have supplied our customers with Top-notch laboratory glassware products and service for over 35 years. We are Quality: Southeastern Lab Apparatous, Inc.(SLA) manufactures and repairs top quality laboratory scientific glassware for chemical, industrial, environmental research and educational laboratories. From the simple to the sophisticated in glassblowing, SLA is equipped yo handle your needs

7475 W. Main StreetSafisis offers fermentation, purification, solvent extraction, and manufacturing services.

Columbia, SC, 29208 United States

6 Medical Park Road Columbia, SC, 29203 United States

96 Jonathan Lucas Street Charleston, SC, 29425 United StatesThe SCTR Research Nexus Laboratory processes biological specimens, provides nucleic acid extraction services, offers a variety of ELISA protocols, and has the ability to develop and customize protocols to fit individual investigator needs. The Biorepository processes and stores biological specimens collected by investigators under IRB-approved protocols. Samples can be retrieved for research purposes for IRB-approved studies. Sample types available include: plasma, DNA and urine.

1483 Tobias Gadson Blvd. Suite 201 Charleston, SC 29407 USAVitrologic specializes in the collection of human biologicals for manufacturing, research and development in allergy, infectious disease, coagulation, oncology, rheumatology, hematology and gastroenterology.

645 Meeting St., Suite 2 Charleston, SC 29403 USAVaxyGen Assay Services provides custom assay services, immunoassays, and database services in support of biopharmaceutical and vaccine development.

5208 Calhoun Memorial Highway Suite C Easley, SC, 29640 United StatesKUR Research has developed the largest and most geographically diverse, *infectious disease biobank*. Our *biobank* is focused on delivering large medical and pharmaceutical companies with a variety of *human biological specimens*. By purchasing samples directly from KUR Research, the companies we service can avoid the lengthy process of procuring samples through a clinical trial. Vexillum currently holds numerous *infectious disease* biospecimens including *SARS-CoV-2*, *Influenza A*, and *Influenza B*. Our diverse site list allows us to easily collect *healthy control* samples for all your *research and development* needs. Not finding what you need in our banked specimens? Vexillum can easily begin a *biospecimen collection* to accommodate your specific needs. Our collection sites are *IRB approved* and ready to collect immediately. Vexillum protocol allows for the collection of various *Human Biospecimens* including *saliva*, *whole blood*, *serum*, *plasma*, *vaginal swabs*, *anterior nasal swabs*, *nasopharyngeal swabs*, *urine* and many more. Our largest project has been the prospective collection of 1000 donors suspected of Acute Upper Respiratory Infestion. The method for this collection was a combination of an all-comers collection and an enriched patient population utilizing standard of care rapid antigen testing. This project was completed in 90 days. To date, the participating sites have been the associated KUR urgent care centers and multidisciplinary private practices. All samples available for purchase are collected by trained and delegated clinical research staff utilizing an *IRB approved* protocol for specimen procurement. Each donor signs *IRB approved Informed Consent* prior to donation. Let us know how we can support your *research*, Vexillum is *making progress possible*.

429 North Church Street Spartanburg, SC, 29303-3663 United StatesWofford College, established in 1854, is an independent liberal arts college located in Spartanburg, S.C. It offers bachelor’s degrees in 25 major fields of study, and is well known for its programs leading to graduate and professional studies (medicine and other health professions, law, commerce, and advanced graduate study across academic disciplines). The college is committed to providing superior students an undergraduate education defined by excellence, engagement and transformation.

2114 Larry Jeffers RoadWeylChem offers API, intermediates, chiral building blocks, custom synthesis and manufacturing services.

503 Robert Grant AvenueWalter Reed Army Institute of Research (WRAIR) focuses on research in malaria and HIV while offering its pilot bioproduction facility to produce and develop vaccines.

6439 Garners Ferry Road Columbia, SC 29209The William Jennings Bryan Dorn VA Medical Center (VAMC) opened in 1932 at its current location. Dorn VAMC has 204 skilled nursing beds, which includes acute medical, surgical, psychiatric, and long-term care. The hospital provides primary, secondary, and some tertiary care. In Fiscal Year (FY) 2013, Dorn VAMC gained 2.8 percent in enrolled patients. In FY 2013, there were a total of 75,813 unique patients including 6,381 female Veterans and 15,829 Veterans from the OIF/OEF/OND period of service. In FY 13, there were 936,424 outpatient visits and 5,005 inpatients treated. The Dorn VAMC provides outpatient care through seven Community Based Outpatient Clinics (CBOC) located in South Carolina in the Upstate, Midlands and Pee Dee areas of South Carolina. The seven CBOCs are located in Anderson, Florence, Greenville, Rock Hill, Orangeburg, Spartanburg and Sumter. All clinics with the exception of Rock Hill are VA employee staffed. The Rock Hill CBOC opened on July 2, 2012, and we opened a new Greenville VA Outpatient Clinic in August 2013. All clinics have a mental health component available.

6439 Garners Ferry Road Columbus, SC, 29209 United StatesThe William Jennings Bryan Dorn VA Medical Center (VAMC) opened in 1932 at its current location. Dorn VAMC has 204 skilled nursing beds, which includes acute medical, surgical, psychiatric, and long-term care. The hospital provides primary, secondary, and some tertiary care. In Fiscal Year (FY) 2013, Dorn VAMC gained 2.8 percent in enrolled patients. In FY 2013, there were a total of 75,813 unique patients including 6,381 female Veterans and 15,829 Veterans from the OIF/OEF/OND period of service. In FY 13, there were 936,424 outpatient visits and 5,005 inpatients treated. The Dorn VAMC provides outpatient care through seven Community Based Outpatient Clinics (CBOC) located in South Carolina in the Upstate, Midlands and Pee Dee areas of South Carolina. The seven CBOCs are located in Anderson, Florence, Greenville, Rock Hill, Orangeburg, Spartanburg and Sumter. All clinics with the exception of Rock Hill are VA employee staffed. The Rock Hill CBOC opened on July 2, 2012, and we opened a new Greenville VA Outpatient Clinic in August 2013. All clinics have a mental health component available.

95 Castle Hall Road P.O. Box 557 Yemassee SC 29945AGI provides domestic-bred and imported rhesus and cynomolgus macaques as well as their biological products (tissue, whole blood serum, plasma, PBMCs etc. We also provide contract research and laboratory services. Contract research areas include pharmacokinetics, compound screening, vaccine testing, efficacy assessment, pharmacology, and early lead optimization. The Center is a full-service facility that provides primate quarantine, colony maintenance, colony support, primate biological products and on site use.

2395 Cains Mill Road Sumter, South Carolina 29154.AAnalytical & Regulatory Chemistry (ARC) is a laboratory that provides analytical, regulatory and formulation services to companies worldwide. Operating under stringent quality assuarnce, our processes assure regulatory compliance with U.S. Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Good Laboratory Practices (GLP). ARC is a privately owned laboratory located in Sumter, South Carolina. The lab has a long history of providing a fast, efficient process for obtaining EPA registrations. The facility has been GLP-compliant since 1998, conducting product-chemistry studies and other EPA-related research projects for more than 20 clients.

3526 Centre Circle Fort Mill, SC, 29715 United StatesAtlantic Sweetener offers supply chain management of food and pharmaceutical ingredients,

1800 Innovation Point Fort Mill, SC, 29715 United StatesFor more than 25 years, life science companies have turned to Xcenda’s leading team of value experts, transforming evidence, policy insights, and market intelligence into effective global market access strategies. Founded in the application of health outcomes and reimbursement, Xcenda, a part of AmerisourceBergen, is a premier consultancy helping clients effectively navigate today’s complex healthcare landscape. Our bench of diverse experts shares a passion to help you deliver the most distinctive body of evidence that demonstrates your value story. We strategically execute on actionable insights and differentiating data. We create innovative communications, models and tools so stakeholders understand not only what you’ve created, but why. It’s our goal to help prove the inherent worth of your products and services, maximize patient access, and enhance your overall brand performance. Trust in our committed team so you can focus on what matters most—helping patients gain access to your brand. Learn more at Xcenda.com.