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Ana G. Mendez University System - Universidad del Este

Highway 190 Km 1.8 Barrio Sabana Abajo Carolina, PRView It is recognized as one of the greatest universities of academic excellence in Puerto Rico and the world. Mission Eastern University is an institution of higher education that is part of the Ana G. Méndez University System. Dedicated academic and service to promote constructivist learning work, respect for diversity and social justice. Its mission is to promote the integral development of persons to be responsible and caring citizens able to contribute to the sustainable development of their environment, through a socio-humanistic education of excellence; valuing research, internationalization, entrepreneurship, technology, culture and community engagement. Beginning The principles that guide the institution are excellence, innovation, justice, respect, freedom of thought and action, solidarity, equity, integrity and social responsibility.

Ana G. Mendez University System - Universidad del Este

Highway 190 Carolina, Carolina Puerto RicoView It is recognized as one of the greatest universities of academic excellence in Puerto Rico and the world. Mission Eastern University is an institution of higher education that is part of the Ana G. Méndez University System. Dedicated academic and service to promote constructivist learning work, respect for diversity and social justice. Its mission is to promote the integral development of persons to be responsible and caring citizens able to contribute to the sustainable development of their environment, through a socio-humanistic education of excellence; valuing research, internationalization, entrepreneurship, technology, culture and community engagement. Beginning The principles that guide the institution are excellence, innovation, justice, respect, freedom of thought and action, solidarity, equity, integrity and social responsibility.

Bio-Nuclear

3 Ave. Simon Madera San Juan, PR 00924Bio-Nuclear offers equipment and services for clinical studies.

Bio-Nuclear

San Juan, San Juan Puerto RicoBio-Nuclear offers equipment and services for clinical studies.

Center for Quantitative Cytometry

San Juan, Puerto RicoThe Center for Quantitative Cytometry (CQC) has been established as a non-profit organization to help standardize quantitative cytometry analysis.

CDI Laboratories

Guanajibo Research and Innovation Park 4005 Street B, Road 114 Km 1.3 Mayaguez, PR, 00682 United StatesThe CDI mission is to empower research and development in proteomics with proprietary technologies, making possible — today — the protein discoveries of tomorrow. CDI's HuProt™ protein microarrays and related services make it possible to perform rapid and efficient analyses of thousands of protein interactions using minimal amounts of valuable research or clinical samples. The Company's microarray-powered monoclonal antibodies (MAbs] and MAb-related services provide unprecedented levels of specificity. Our system of antibody production is part of the NIH Protein Capture Reagents program and is currently working to produce truly mono-specific antibodies to human transcription factors. CDI has patents in process for technologies to increase high through put analysis of protein-protein interactions as well as high throughput development of antibodies and identification of biomarkers At CDI we believe that partnering with both companies and academic scientists is the path to mutual success. So please contact our business development professionals for possible collaborations or partnerships. The Company has locations in Baltimore, Maryland and in Mayaguez, Puerto Rico.

Eqlab

Bayamón, Bayamón Puerto RicoEnvironmental Quality Laboratories (Eqlab) offers analytical testing of water, hazardous wastes, and raw materials.

Lumur

Ave. Jesus T. Piñero 1434 2nd. FloorLumur provides equipment for sale or rental, calibration services, and maintenance services.

Mutchler Inc.

PO Box 373190 Cayey, PR 00737-3190Mutchler provides a complete range of pharmaceutical excipients and other specialty ingredients to the pharmaceutical industry. We pride ourselves on being a leader in innovative distribution and technical marketing of top quality ingredients and services. We also offer Added Value Services (AVS) for excipients to help build efficiencies into your supply chain. Our AVS include sampling, release testing, repacking, weighing and other specialty requests.

PharmLogic International LLC

1225 Ave Ponce de Leon Suite PH5 San Juan, PR, 00907 United StatesPharmLogic is a big data SaaS and Services firm dedicated to providing solutions to the life science industry by combining best in class cloud-based technology with a global services support model.

Pace Analytical Life Sciences

Ó Calle C Calle B & C San Germán, San Germán, 00683 Puerto RicoPace Analytical Life Sciences (PLS) provides CDMO / CRO services to help improve human health by supporting the Pharmaceutical / Biopharmaceutical / Biologics innovators - to support Pharmaceutical Drug Development, Pharmaceutical Manufacturing, and Biopharmaceutical / Biologics manufacturing. Our teams have world-class expertise with small molecule, biologic, oligonucleotide and hybrid products: • Characterize new therapeutic molecules (preformulation) • Synthetic small molecules, • Biologics such as proteins, peptides, antibodies, antibody drug conjugates • Gene therapies such as oligonucleotides • Formulation development • Lyophilization process development • Spray-drying , Hot-Melt Extrusion (HME), Nano-milling • Phase-appropriate analytical development • Test Article Preparation • Clinical Trial Materials (CTM) - Sterile & non-Sterile dosages through Phase 2 • Clinical Packaging Full service, cGMP-compliant, Chemistry and Microbiology contract laboratory services. As an FDA-registered, GMP contract laboratory services provider, we help to ensure the quality of marketed pharmaceutical products by providing chemistry and microbiology services: • Facility Environmental Monitoring • Raw Materials Clearance Programs • Finished Product Testing • Method Development and Validation • In-process & Finished Product Testing • ICH Stability Storage & Testing • Reference Standards Programs • Extractable / Leachable studies • Dissolution drug release, • Elemental metals, • Microbiology Testing Services • Microbial limits, • Sterility Pace Analytical Life Sciences (PLS) provides services to help improve human health. We provide contract product development to help bring new therapies to market and contract laboratory services to ensure the purity, potency, safety, efficacy, and shelf life of pharmaceutical and medical products.

Pharmalex

30 Calle Padial Caguas, Caguas, 00725 Puerto RicoPharmaLex is a leading provider of specialized services for the pharma, biotech and medical device industries. We guide you from early strategic planning activities and non-clinical requirements through clinical development, regulatory submission processes and post-approval / maintenance post-launch activities. Our experts use technology-enabled solutions to support you through the entire product lifecycle. We deliver exceptional results — going above and beyond the standard to deliver tailor-made solutions worldwide.

Ponce Health Sciences University School of Medicine

388 ZONA IND. REPARADA 2 PONCE , 00716-2347 Puerto RicoPonce Health Sciences University is dedicated to providing the highest quality graduate medical education programs available. This goal, in addition to the university’s research and health services programs, continues a 37 year tradition of enhancing our profession and contributing to our community. Recognized both in Puerto Rico and abroad for educational service and research achievements, the university continues its focus in the disciplines of Medicine, Clinical Psychology, Biomedical Sciences and Public Health. To meet future challenges in the healthcare industry, the university is launching an innovative selection of masters and certificate programs specifically designed to fill service gaps within the profession and enhance the healthcare community with highly trained practitioners. Our commitment to educational excellence is an underlying value that leads the university to seek and recruit not only outstanding faculty but also outstanding students. By combining expanded academic and professional educational offerings in a cooperative and intimate learning environment, the Ponce Health Sciences University continues to graduate highly competent healthcare professionals dedicated to their community and the expanding future needs of their profession.

Patheon

State Road 670 Km. 2.7 Manatí, Peurto Rico 00674Patheon is the leading publicly listed provider of drug development and manufacturing services to global pharmaceutical, biotechnology and specialty pharmaceutical companies.

Pharma-Bio Serv Inc.

Dorado Industrial Zone Lot 14 Street 1 Dorado Puerto RicoSince our inception over twenty years ago, we have focused on developing a technical, administrative, and human resources infrastructure with a single purpose: to provide integrated quality, productivity and compliance services to highly-regulated manufacturers throughout the globe. To meet the needs of the times, we have integrated our services to make certain that all the compliance, risk-management, knowledge-management, and workforce needs of our global partners are addressed in ways that provide the desired operational and compliance result.

Randox

PO Box 29029 San Juan, PR 00929-0029Randox Laboratories, through its business units, offer diagnostic services, life science reagents, biomarker testing services, antibody/drug assay development, and toxicology services.

Sartorius Stedim Biotech

Validation Lab Laboratory Road 128, Intersection 376 Yauco, 00698 Puerto RicoSartorius Stedim BioOutsource Ltd. is a leading provider of contract testing services to the global biopharmaceutical and biotechnology industries. BioOutsource has operations in both Europe and the USA, with testing laboratories in Glasgow, UK, and Cambridge, MA, USA. BioOutsource was founded in 2007 and was acquired by Sartorius Stedim Biotech in 2015. We are accredited for cGMP, GLP and GCP and provide contract testing services to assess the quality and safety of biologic drugs and vaccines including: A range of off-the-shelf assays for biosimilar characterization and comparability Biosafety testing of cell banks and bulk harvest as well as cell line stability and lot release At Sartorius, we don’t just perform contract testing services; we are committed to delivering service excellence, with an in-house R&D department, we are constantly adding to our existing portfolio of services to address market demands. Our innovative approach and client management model ensure’s projects are managed efficiently, cost-effectively and delivered on-time.

Sartorius Stedim Biotech

Road 128, Intersection 368 Bo Susua Boja, Susua Industrial Park Yauco, Puerto Rico, 00698 United StatesSartorius Stedim BioOutsource Ltd. is a leading provider of contract testing services to the global biopharmaceutical and biotechnology industries. BioOutsource has operations in both Europe and the USA, with testing laboratories in Glasgow, UK, and Cambridge, MA, USA. BioOutsource was founded in 2007 and was acquired by Sartorius Stedim Biotech in 2015. We are accredited for cGMP, GLP and GCP and provide contract testing services to assess the quality and safety of biologic drugs and vaccines including: A range of off-the-shelf assays for biosimilar characterization and comparability Biosafety testing of cell banks and bulk harvest as well as cell line stability and lot release At Sartorius, we don’t just perform contract testing services; we are committed to delivering service excellence, with an in-house R&D department, we are constantly adding to our existing portfolio of services to address market demands. Our innovative approach and client management model ensure’s projects are managed efficiently, cost-effectively and delivered on-time.

Universidad Central Del Caribe SoM IBRO Protein and Nucleic Acid Core Facility

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center unifies a multi-institutional group of researchers focused on glial cell investigation and oriented to disorders originated by or related to glial cell function and pathology. The center represents scientific research groups from UCC, UPR and Interamerican University (Bayamon). At UCC there is a large group of researchers from the basic sciences departments who share interrelated research interests in neuroglial cell physiology, molecular biology, biochemistry, pharmacology and biophysics. The Center has developed a core facility named The Innovative Glial Technology Core: which provides new techniques to investigate glial cell functions. This is necessary because glial cells (the “silent brain”) do not generate spikes. Instead, glial signaling in brain is through molecular and ionic mechanisms inside of the glial syncitium and between glial and neurons. The signaling avenues use a wide variety of molecules which can be detected with the help of new techniques developed and installed by the core. In addition, the Center uses common core facilities, such as the Common Instrumentation Area, the Optical Imaging Facility and the Protein and Nucleic Acid Core Facility, Behavioral Testing Facility and the Neuronal Glial Culture Facility which provide services to Center members.

Universidad Central Del Caribe SoM IBRO The Innovative Glial Technology Core

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center unifies a multi-institutional group of researchers focused on glial cell investigation and oriented to disorders originated by or related to glial cell function and pathology. The center represents scientific research groups from UCC, UPR and Interamerican University (Bayamon). At UCC there is a large group of researchers from the basic sciences departments who share interrelated research interests in neuroglial cell physiology, molecular biology, biochemistry, pharmacology and biophysics. The Center has developed a core facility named The Innovative Glial Technology Core: which provides new techniques to investigate glial cell functions. This is necessary because glial cells (the “silent brain”) do not generate spikes. Instead, glial signaling in brain is through molecular and ionic mechanisms inside of the glial syncitium and between glial and neurons. The signaling avenues use a wide variety of molecules which can be detected with the help of new techniques developed and installed by the core. In addition, the Center uses common core facilities, such as the Common Instrumentation Area, the Optical Imaging Facility and the Protein and Nucleic Acid Core Facility, Behavioral Testing Facility and the Neuronal Glial Culture Facility which provide services to Center members.

Universidad Central Del Caribe SoM Center for Addiction Studies

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center for Addiction Studies (know as CEA for its initial in Spanish) was establish with the purpose of expanding scientific knowledge on substance abuse, HIV/AIDS and related topics. The objectives of the center are 1) To estimate the prevalence of drug use, abuse and dependence in the Puerto Rican population. 2) Describe the patterns of drug use and associated factors, 3) Examine the relationship between substance abuse and other physical and mental health conditions. The center aims to provide empirical knowledge as the base for the preparation of health professionals that provide substance abuse and drug treatment services. The center also maintains scientific databases that serve as reference for public policy making. Research Projects: •HIV Risks and Transitions to Injection Among Non-IDUs •HIV Risk Behaviors in Preparation of Injectable Drugs •Puerto Rico Drug Abuse Research Development Program •Risky Families Embedded in Risky Environments

Universidad Central Del Caribe SoM IBRO Neuronal Glial Culture Facility

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center unifies a multi-institutional group of researchers focused on glial cell investigation and oriented to disorders originated by or related to glial cell function and pathology. The center represents scientific research groups from UCC, UPR and Interamerican University (Bayamon). At UCC there is a large group of researchers from the basic sciences departments who share interrelated research interests in neuroglial cell physiology, molecular biology, biochemistry, pharmacology and biophysics. The Center has developed a core facility named The Innovative Glial Technology Core: which provides new techniques to investigate glial cell functions. This is necessary because glial cells (the “silent brain”) do not generate spikes. Instead, glial signaling in brain is through molecular and ionic mechanisms inside of the glial syncitium and between glial and neurons. The signaling avenues use a wide variety of molecules which can be detected with the help of new techniques developed and installed by the core. In addition, the Center uses common core facilities, such as the Common Instrumentation Area, the Optical Imaging Facility and the Protein and Nucleic Acid Core Facility, Behavioral Testing Facility and the Neuronal Glial Culture Facility which provide services to Center members.

Universidad Central Del Caribe SoM Neuroscience Research Center

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe primary mission of the Neuroscience Research Center is to foster and conduct science of the highest caliber that advances the understanding of brain function and diseases that affect the nervous system. The Center maintains a quality research environment highly conducive to productive and clinically-oriented basic research focused on Neuroscience. The Center’s scientists share common interests in understanding the biology of neurological disorders and work toward the shared goal of ultimately developing novel methods of diagnosis and treatment of the disorders. The Center originally named Center for Molecular and Behavioral Neuroscience (CMBN) was established in 1990 for the purpose of promoting neuroscience research in Puerto Rico and organized as an inter-institutional association of neuroscientists with headquarters at the UCC. Currently, composed of 17 scientists from four Puerto Rican universities, in addiction to associate and student members. Close to 20 research projects address issues ranging from the basic mechanism(s) of cocaine addiction, excitotoxicity and neuroprotection, to ion channel function and signal transduction pathways. This center also organizes the Puerto Rico Neurosciences Conference, held annually since 1992. Research Projects: •Noradrenergic modulation of glutamate transmission in the prefrontal cortex in cocaine sensitization. •Characterization of the cembranoid binding site on the nicotinic acetylcholine receptor. •Behavioral sensitization to nicotine-relevance to neuroprotection. •Cembranoids and RNA’s: New Tools to Study Receptors. •The Structure of the ionotropic acetylcholine receptor from Torpedo californica.

Universidad Central Del Caribe SoM Retrovirus Research Center

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Retrovirus Research Center is a multidisciplinary research center for the study of HIV/AIDS and other Retroviruses. The center promotes the study of HIV infection as a multidisciplinary research arena in which the clinical features, immunological, and virological elements and the psychological and behavioral parameters need to be integrated into a coherent research strategy. The center brings together a coalition of multidisciplinary researchers whose interest is to describe and understand key elements that play a role in the progression and/or expression of HIV infection according to an ecological view of the problem. Research Projects: •HIV/AIDS Data Core: Studies the natural history of AIDS disease among the Puerto Rican population. •HCV Risk Reduction Intervention as Secondary Co-Morbidity Prevention •ASUMA: A Supportive Model for HIV Risk Reduction in Early Adolescents

University of Puerto Rico - Translational Proteomics Core

San Juan, 00931 Puerto Rico

Universidad Central Del Caribe SoM Cellular and Molecular Biology Center

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Cellular and Molecular Biology Center is an interdisciplinary group of researchers from all of the basic sciences departments at our Institution who share common and interrelated research interests in cell and molecular biology. The Center coordinates two core facilities, the Optical Imaging Facility and the Protein and DNA Core Facility, which offer services to Center members and the general scientific community. The Center also coordinates seminars, workshops and an Annual Retreat for UCC researchers, where conceptual and technical advances in cell and molecular biology are presented and demonstrated by distinguished visiting scientists and commercial instrumentation representatives. Center researchers mainly work in the areas of signal transduction and functional genomics. Research Projects: •Oxidative DNA Damage and Oxysterol-induced Apoptosis •Membrane cholesterol and lipid-protein interaction alters the AChR function •Glial polyamine regulation of the neuronal-glial network •Functional role of potassium channels in astrocytes •Regulation of Kir channels in retinal cells •Mechanisms of immunosuppression in modeled microgravity •Norepinephrine and cocaine sensitization. •Repair of AP sites and aging in S. cerevisia •NPY and Nucleotides Signaling in Vascular Endothelial Cells •Structure-Function Relationship of Muscarinic Toxin MT7 •Non genomic action of thyroid hormones in the amphibian neuromuscular junction

Universidad Central Del Caribe SoM IBRO Optical Imaging Facility

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center unifies a multi-institutional group of researchers focused on glial cell investigation and oriented to disorders originated by or related to glial cell function and pathology. The center represents scientific research groups from UCC, UPR and Interamerican University (Bayamon). At UCC there is a large group of researchers from the basic sciences departments who share interrelated research interests in neuroglial cell physiology, molecular biology, biochemistry, pharmacology and biophysics. The Center has developed a core facility named The Innovative Glial Technology Core: which provides new techniques to investigate glial cell functions. This is necessary because glial cells (the “silent brain”) do not generate spikes. Instead, glial signaling in brain is through molecular and ionic mechanisms inside of the glial syncitium and between glial and neurons. The signaling avenues use a wide variety of molecules which can be detected with the help of new techniques developed and installed by the core. In addition, the Center uses common core facilities, such as the Common Instrumentation Area, the Optical Imaging Facility and the Protein and Nucleic Acid Core Facility, Behavioral Testing Facility and the Neuronal Glial Culture Facility which provide services to Center members.

Universidad Central Del Caribe SoM IBRO Behavioral Testing Facility

PO BOX 60327 Bayamon, 00960-6032 Puerto RicoThe Center unifies a multi-institutional group of researchers focused on glial cell investigation and oriented to disorders originated by or related to glial cell function and pathology. The center represents scientific research groups from UCC, UPR and Interamerican University (Bayamon). At UCC there is a large group of researchers from the basic sciences departments who share interrelated research interests in neuroglial cell physiology, molecular biology, biochemistry, pharmacology and biophysics. The Center has developed a core facility named The Innovative Glial Technology Core: which provides new techniques to investigate glial cell functions. This is necessary because glial cells (the “silent brain”) do not generate spikes. Instead, glial signaling in brain is through molecular and ionic mechanisms inside of the glial syncitium and between glial and neurons. The signaling avenues use a wide variety of molecules which can be detected with the help of new techniques developed and installed by the core. In addition, the Center uses common core facilities, such as the Common Instrumentation Area, the Optical Imaging Facility and the Protein and Nucleic Acid Core Facility, Behavioral Testing Facility and the Neuronal Glial Culture Facility which provide services to Center members.