Reset Map

383 Results

Clinquest

Rossinistraat 46 Oss, 5344 AK NetherlandsClinquest provides drug development consulting, clinical trial implementation, and safety surveillance overview.

Chemonaut

Delft, The NetherlandsChemonaut offers screening compounds, building blocks, pharmacore moodeling, virtual screening and docking services.

Chemonaut

Delftechpark 26 2628 XH Delft The NetherlandsChemonaut offers screening compounds, building blocks, pharmacore moodeling, virtual screening and docking services.

Crucell

Archimedesweg 4-6 2333 CN LeidenCrucell focuses on research and development of therapeutic proteins and antibodies.

Cytocentrics

Eindhoven, The NetherlandsCytocentrics AG provides cutting-edge solutions to assist drug screening of ion channel targets, especially in early drug profiling and safety pharmacology

Crystallics

Meibergdreef 31 Amsterdam, 1105AZ NetherlandsArdena Amsterdam offers solid form screening/selection, crystal process optimization, and X-Ray Diffraction services.

DDL Diagnostic Laboratory

Visseringlaan 25, 2288ER, Rijswijk, the NetherlandsDDL Diagnostic Laboratory (DDL) is a state-of-the-art laboratory specialized in (molecular) diagnostic testing and assay development. DDL performs advanced molecular diagnostic testing on behalf of pharmaceutical companies and clinical laboratories,supporting Phase II-IV clinical trials. DDL also designs, develops, and validates novel diagnostic assays, which can be tailor-made for specific diagnostic purposes. DDL is based in Rijswijk, the Netherlands, and has a core team of ~75 quality-minded employees with proven scientific and clinical laboratory experience. Therefore, DDL can offer state-of-the-art diagnostic services to its customers, and can provide flexible, creative, and cost-effective diagnostic solutions.

DDL Diagnostic Laboratory

Visseringlaan 25 Rijswijk, 2288ER NetherlandsDDL Diagnostic Laboratory (DDL) is a state-of-the-art laboratory specialized in (molecular) diagnostic testing and assay development. DDL performs advanced molecular diagnostic testing on behalf of pharmaceutical companies and clinical laboratories,supporting Phase II-IV clinical trials. DDL also designs, develops, and validates novel diagnostic assays, which can be tailor-made for specific diagnostic purposes. DDL is based in Rijswijk, the Netherlands, and has a core team of ~75 quality-minded employees with proven scientific and clinical laboratory experience. Therefore, DDL can offer state-of-the-art diagnostic services to its customers, and can provide flexible, creative, and cost-effective diagnostic solutions.

DuSart Pharma

Nijverheidstraat 15 2222 AV Katwijk NetherlandsDuSart Pharma offers research, development, production and distribution of food supplements, nutraceuticals, sports foods, cosmetic products, natural medicines and Medical Devices.

Dorian Regulatory Affairs

Soestdijkerstraatweg 7 1213 VP Hilversum, The NetherlandsDorian Regulatory Affairs specializes in development and registration of pharmaceutical products in Europe.

DSM RESOLVE

22 Urmonderbaan Geleen, LI, 6163 NetherlandsThe border between the earth and sky changes whenever you change your perspective.

Derphartox BV

Rotterdam, ZH, 3015 AA Netherlands

Dishman Pharmaceuticals and Chemicals

Veenendaal, The NetherlandsDishman CRAMS offers development services, kilo supply, cGMP pilot production and full scale cGMP manufacture.

Disphar

Winkelskamp 6 7255 PZ Hengelo (Gld) The NetherlandsDisphar offers services in product development, regulatory affairs, quality assurance and pharmacovigilance.

Disphar

Tolweg 15 3741 LM Baarn The NetherlandsDisphar offers services in product development, regulatory affairs, quality assurance and pharmacovigilance.

Disphar

Baarn, UT NetherlandsDisphar offers services in product development, regulatory affairs, quality assurance and pharmacovigilance.

DSM Pharmaceuticals

Heerlen, NLDSM provides custom manufacturing, cell culture fermentation, purification, formulation, and clinical trials.

DSM Pharmaceuticals

Urmonderbaan 22 6167 RD Geleen The NetherlandsDSM provides custom manufacturing, cell culture fermentation, purification, formulation, and clinical trials.

DSM Pharmaceuticals

Het Overloon 1 6411 TE Heerlen NetherlandsDSM provides custom manufacturing, cell culture fermentation, purification, formulation, and clinical trials.

Arcarios NV

Arcarios BV Dr. Molewaterplein 40 3015 GD RotterdamArcarios is a drug development company dedicated to the discovery and development of innovative products in the field of bone and joint diseases such as osteoporosis and osteoarthritis. Current treatment options are insufficient and indicate an urgent need for disease modifying drugs. The company’s proprietary technology platform allows for the successful development of treatments focussed on restoring cartilage and bone, thereby addressing an important unmet medical need in today’s society. Having two advanced therapeutic programs with a strong technology and IP position, Arcarios is well positioned to capitalize on the market opportunity in the field of osteoarthritis and osteoporosis.

Arcarios NV

40 Doctor Molewaterplein Rotterdam, ZH, 3015 GD NetherlandsArcarios is a drug development company dedicated to the discovery and development of innovative products in the field of bone and joint diseases such as osteoporosis and osteoarthritis. Current treatment options are insufficient and indicate an urgent need for disease modifying drugs. The company’s proprietary technology platform allows for the successful development of treatments focussed on restoring cartilage and bone, thereby addressing an important unmet medical need in today’s society. Having two advanced therapeutic programs with a strong technology and IP position, Arcarios is well positioned to capitalize on the market opportunity in the field of osteoarthritis and osteoporosis.

Da Vinci Laboratory Solutions

10 Caïrostraat Rotterdam, ZH, 3047 BC NetherlandsDa Vinci Laboratory Solutions (DVLS) was established as a laboratory support provider in 2000. Today Da Vinci has become the versatile partner to laboratories by offering chromatographic solutions that address all analytical challenges starting from sample preparation, analysis,reporting, data management up to providing technical support and supplies. Our mission is to boost laboratory efficiency through:Chromatographic solutions of Da Vinci Expertise in GC, LC, MS, TOC, XRF and software development Knowledge of laboratory processes Distributorship of leading suppliers such as Agilent, GERSTEL, LECO, VUV Analytics and XOS Development and manufacturing of innovative solutions As a result of our wide range of solutions and high level of expertise Da Vinci is able to meet all analytical needs. Contact us on your analytical challenges.

Erasmus MC - Center For Biomics

80 Wytemaweg Rotterdam, ZH, 3015 Netherlands

Euretos

Yalelaan 1 Utrecht, Utrecht, 3584 CL NetherlandsEuretos provides contract research services and cloud access to the Euretos AI Platform for disease and drug research. We use AI technologies such as machine reading and learning, to create data driven disease insights into the systems biological, molecular mechanisms that drive phenotypes, disease pathology, toxicity and drug response. These data driven disease insights help researchers to be more effective in fundamental disease research, preclinical discovery & clinical validation of targets, biomarkers and indications. Our machine reading technology interprets and connects hundreds of public databases and millions of scientific publications to provide the largest knowledge base where multi omics data is interlinked to literature, patents, experimental and clinical evidence

EnzyTag

Daelderweg 9 Nuth, HK, 6361 NetherlandsEnzyTag has developed the peptiligase technology. This technology offers an entry into economic manufacturing processes for linear peptide drugs and small proteins. The potential of the peptiligase technology however extends far beyond linear peptides and small proteins, to areas such as macrocyles (cyclotides), antibody-drug conjugates and conjugated dual inhibitors. We wish to explore such opportunities with interested customers and clients.

EnzyTag

Daelderweg 9 Nuth, Choose A State, 6361 HK NetherlandsEnzyTag has developed the peptiligase technology. This technology offers an entry into economic manufacturing processes for linear peptide drugs and small proteins. The potential of the peptiligase technology however extends far beyond linear peptides and small proteins, to areas such as macrocyles (cyclotides), antibody-drug conjugates and conjugated dual inhibitors. We wish to explore such opportunities with interested customers and clients.

Enestia

Klöcknerstraat 1 3930 Hamont-Achel België / BelgiqueEnestia provides both contract manufacturing and contract packaging for healthcare companies.

Eurosequence

Meditech Center L.J. Zielstraweg 1 9713 GX Groningen The NetherlandsEurosequence offers protein sequence analysis, amino acid analysis, protein sequencing, protein identification with mass spectrometry, and peptide synthesis services.

EuroCept

Trap Gans May 1244 RL Ankeveen NetherlandsEuroCept offers medicines, hospital care, medical technology and distribution.

ERASMUS MC - Proteomics Core

Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN RotterdamErasmus MC is committed to a healthy population and excellence in healthcare through research and education.

ERASMUS MC - Proteomics Core

Proteomics Center Erasmus MC Office Ee-679A | Lab Ee-626 Wytemaweg 80 3015 CN RotterdamErasmus MC is committed to a healthy population and excellence in healthcare through research and education.

European Packaging Centre

P.O.Box 713 8440 AS Heerenveen The NetherlandsEuropean Packaging Centre provides pharmaceutical contract-manufacturer and packaging.

ENPICOM

Sint Janssingel 88 s'Hertogenbosch , Noord-Brabant, 5211DA NetherlandsENPICOM is an innovative bioinformatics software engineering company with an outstanding team of over 30 professionals. We provide a cloud based solution that enables any scientist to analyse the immune receptor repertoire. Together with leading experts in the fields of antibody discovery, TCR identification, and vaccine development, ENPICOM has developed the IGX Platform. The IGX Platform empowers life scientists to independently perform complex analyses and focus on what matters most: their research.

Enzyscreen

Wassenaarseweg 72 2333 AL Leiden The NetherlandsEnzyscreen provides custom screening and development of miniaturized growth systems.

Enzyscreen

Leiden, ZH NetherlandsEnzyscreen provides custom screening and development of miniaturized growth systems.

Exploras Agro Development BV

4 Willem Elsschotstraat Dongen, NB, 5103 PM NetherlandsExploras Agro Development has started in 2010 and has transformed to a BV in 2012. The core activities of Exploras Agro Development are the processing of field trials and the offering of services for amongst others the agro chemical industry, fertilizer- and seed companies. Further more agro supply companies, advisory agencies, grower organizations and individual growers can apply to Exploras Agro Development for trials. Exploras Agro Development is specialised in field vegetables, such as cabbage, leek, carrot, lettuce, celery, broad beans, chicory roots, endive, spinach. More over also strawberries belong to the crop parcel. As a result of expension also research in arable crops, flower bulbs and fruitcan be offered. Exploras Agro Development has a GEP and TNG acknowledgement and is competent in processing field trials with agro chemicals. USP’s of Exploras Agro Development are: High quality of field trials: The trials are conducted mostly according to EPPO guidelines and therefore meet the GEP requirements. Furthermore, there is a lot of attention spent on artificial infection to improve the probability of success. Short communication lines with assignment provider: Exploras Agro Development is a cooperative thinker in finding solutions and gives you direct feedback at unsuspected developments before, during and after the process of the trials. Shortly, Exploras Agro Development is working as an extension of the assignment provider. Prompt reporting: Exploras Agro Development guarantees a complete report within two months after finishing your project. The cooperation in field trials is found in reliable field vegetable growers with feeling for research. As many trials as possible will be concentrated at Rinus van de Riet, a grower in Etten-Leur. Rinus takes care of the growing and will assist in the trial activities.

Environ

Willem Arnszlaan 115 3734 EE Den Dolder The NetherlandsA premier global consultancy, Ramboll Environ is trusted by clients to manage their most challenging environmental, health and social issues. We have earned a reputation for technical and scientific excellence, innovation and client service. Our independent science-first approach ensures that our strategic advice is objective and defensible. We apply integrated multidisciplinary services and tailor each solution to our client’s specific needs and challenges.

European Infrastructure for Translational Medicine (EATRIS)

Giovanni Migliaccio, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands

FUJUFILM VisualSonics, Inc.

Joop Geesinkweg 140 1114 AB Amsterdam, The NetherlandsFujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research and is a wholly owned subsidiary of SonoSite, Inc. VisualSonics’ imaging technologies allow researchers at pharmaceutical and biotechnology companies, hospitals and universities to conduct research in cardiovascular, cancer, neurobiology and developmental biology areas. The micro-imaging technologies support research applications that include genetic research, phenotypic studies and drug development. VisualSonics high-frequency micro-imaging and photoacoustic platforms combine high-resolution, real-time in vivo imaging with quantifiable data that have been published in over 850 scientific publications globally.

Farma Research Animal Health

Nijmegan, The NetherlandsFarma Research Animal Health provides in-life phase and bioanalytical phase animal studies, regulatory affairs, and environmental risk assessment.

Future Diagnostics

Nieuweweg 279 Wijchen, 6603 BN The NetherlandsFuture Diagnostics offers diagnostic assays with specialties in anemia, autoimmune, bone metabolism, cardiovascular, diabetes, endocrine, fertility, hematology, infectious disease, and cancer.

Future Diagnostics

Wijchen, GE NetherlandsFuture Diagnostics offers diagnostic assays with specialties in anemia, autoimmune, bone metabolism, cardiovascular, diabetes, endocrine, fertility, hematology, infectious disease, and cancer.

ForTe

Lindenlaan 31c 6584 AC MOLENHOEK (LB) The NetherlandsForTe offers product & formulation technology development for the pharmaceutical, cosmeceutical and food industries.

FeyeCon

Rijnkade 17a 1382 GS Weesp The NetherlandsFeyeCon specializes in using carbon dioxide technologies to support pharmaceutical formulations.

FeyeCon

Weesp, NH NetherlandsFeyeCon specializes in using carbon dioxide technologies to support pharmaceutical formulations.

FOSS NIRSystems

Primulastraat 11 5595 EL Leende The NetherlandsFOSS NIRSystems supplies near-infrared (NIR) spectroscopy analyzers to support process development, raw materials testing, finished product testing, content uniformity testing, process monitoring, end-point determination, fluid bed drying, quality control and stability testing.

Good Biomarker Sciences

Zernikedreef 8 2333 CL Leiden The NetherlandsGood Biomarker Sciences (GBS Leiden) provides fit-for-purpose analytical services. GBS Leiden scientists are specialized in haemostasis, and immunomodulation with a focus on functional assays. We offer scientific and analytical support for clinical trials, population studies and pre-clinical drug development. Our methods provide continuity through pre-clinical and clinical studies to accelerate drug development.

Genome Diagnostics

Utrecht, The NetherlandsGenome Diagnostics offers sequencing software and HLA typing.

Global Pathology Support

Benoordenhoutseweg 23 The Hague, 2596 BA The NetherlandsGlobal Pathology Support focuses on histopathology assessment including histology and immunohistochemistry services.

GenomeScan

1d Plesmanlaan Leiden, ZH, 2333 NetherlandsGenomeScan offers genomic services for the pharmaceutical industry based on genetic profiling using Next Generation Sequencing (NGS) techniques. These services include Patient Stratification strategies using WGS/WES, Trancriptome and and Epigenetic analysis. In addition since 2011 we are ISO 17025 accredited to ensure a guaranteed quality for our portfolio. On top of that we are able to work G(C)LP compliant. We also offer diagnostic genetic tests using NGS techniques. We provide a complete portfolio of the most modern techniques, including: • ExomeScan • (Targeted) panel sequencing : MODYScan, MuscleScan etc. • Transcriptomics • Epigenetics Our fully automated laboratory specializes in whole exome sequencing (WES) including FFPE sequencing and ‘ExomeScan Priority’ (ultra-fast TAT). We offer various inheritable disease panels, or we can create your custom design. The RNAseq services and data-analysis pipelines measure differential expression such as tumor vs. normal DNA. Or you can perform (targeted) methylation sequencing or micro-array analyses. Innovation by our R&D department keeps our services at the forefront of industry. Over 15 years we have been a highly regarded genomic service provider. Our tight collaboration with clinical specialists of the Leiden University MC (LUMC) and Erasmus MC ensures high quality data-interpretation. Both our collaborators have complementary proficiencies so we can provide you with in-depth clinical knowledge and additional products.

GenomeScan

Plesmanlaan 1d Leiden, 2333 BZ NetherlandsGenomeScan offers genomic services for the pharmaceutical industry based on genetic profiling using Next Generation Sequencing (NGS) techniques. These services include Patient Stratification strategies using WGS/WES, Trancriptome and and Epigenetic analysis. In addition since 2011 we are ISO 17025 accredited to ensure a guaranteed quality for our portfolio. On top of that we are able to work G(C)LP compliant. We also offer diagnostic genetic tests using NGS techniques. We provide a complete portfolio of the most modern techniques, including: • ExomeScan • (Targeted) panel sequencing : MODYScan, MuscleScan etc. • Transcriptomics • Epigenetics Our fully automated laboratory specializes in whole exome sequencing (WES) including FFPE sequencing and ‘ExomeScan Priority’ (ultra-fast TAT). We offer various inheritable disease panels, or we can create your custom design. The RNAseq services and data-analysis pipelines measure differential expression such as tumor vs. normal DNA. Or you can perform (targeted) methylation sequencing or micro-array analyses. Innovation by our R&D department keeps our services at the forefront of industry. Over 15 years we have been a highly regarded genomic service provider. Our tight collaboration with clinical specialists of the Leiden University MC (LUMC) and Erasmus MC ensures high quality data-interpretation. Both our collaborators have complementary proficiencies so we can provide you with in-depth clinical knowledge and additional products.

Griffin Discoveries

Griffin Discoveries BV Department of Medicinal Chemistry Room P-246 De Boelelaan 1083 1081 HV Amsterdam The NetherlandsGriffin Discoveries provides screening services, medicinal chemistry, and molecular pharmacology.

Gentaur

5521 Eersel, The NetherlandsGentaur is a supplier of life science research products.

GenScript

Robert Boyleweg 4, Leiden, 2333 CG NetherlandsGenScript is a leading global biotechnology corporation providing gene, peptide, protein, CRISPR, and antibody services to biotech, pharma, and academic partners worldwide. Based on its independent and superior gene synthesis technology, GenScript has become the largest gene synthesis provider worldwide. Building upon the strengths of next-generation semiconductor-based DNA synthesis, GenScript provides precise mutant library services supporting antibody and protein optimization. Additional specialized services for monoclonal antibody development expedite the discovery of high-quality antibodies with broad epitope specificities in a cost-effective manner. GenScript offers a broad range of catalog products, therapeutic and diagnostic supporting materials, and research instruments to provide scientists worldwide with simple, fast, and effective research solutions. Continued innovation and development of capabilities and resources have enabled GenScript’s impressive business expansion. In addition to its original CRO platform, GenScript has established a contract development and manufacturing organization (CDMO), a global cell therapy group, and an industrial synthetic products platform. These collective platforms enable GenScript to provide comprehensive solutions for biologics’ discovery and development, CAR-T cell therapy strategies, and the development of industrial enzymes. By 2020, GenScript’s workforce of over 3,000 employees, with ~30% holding Master’s and/or Ph.D. degrees, were located in subsidiaries, R&D, and manufacturing facilities across the US, Europe, and Asia. Over the past 18 years, GenScript has grown exponentially through partnerships with scientists conducting basic life science research, translational biomedical research, and early-stage pharmaceutical development.

Human Metabolome Technologies (HMT)

21 J.H. Oortweg Leiden, ZH, 2333 CH NetherlandsHMT-America develops and offers mass spectrometry-based metabolic profiling services. Our unique CE-MS and LC-MS platforms provide quantitative and untargeted measurements for primary metabolism and profiling for many types of samples and applications. Based on statistical, multivariate and pathway analyses, our research coordinators support the study design and biological interpretation.

Hubrecht Organoid Technology (HUB)

Yalelaan 62 Utrecht, 3584 CM NetherlandsHubrecht Organoid Technology (HUB) was founded by the Hubrecht Institute, the University Medical Center Utrecht, and the Royal Netherlands Academy of Arts and Sciences (KNAW) to refine organoid development and foster organoid adoption globally. HUB Organoid Technology represents a paradigm-shift that bridges the gap between the lab and the clinic and effectively brings “patients in the lab” for drug discovery and development, preclinical patient stratification, predictive biomarker discovery, personalized medicine, clinical trials, regenerative medicine, and companion diagnostics applications.

Hycult Biotech

Frontstraat 2a 5405 PB Uden The NetherlandsHycult Biotech offers monoclonal and polyclonal antibodies, recombinant proteins, peptides, and ELISA kits.

Hycult Biotech

Uden, NB NetherlandsHycult Biotech offers monoclonal and polyclonal antibodies, recombinant proteins, peptides, and ELISA kits.

HemoLab

Den Dolech2 5612 AZ Eindhoven The NetherlandsHemoLab offers tissue and organ acquisition as well as consulting services.

HLB B.V.

27 Kampsweg Wijster, DR, 9418 PD NetherlandsHLB continually develops new expertise in the field of plant and soil health and applies this knowledge throughout the agri-chain. Our unique combination of research, diagnosis and advice gives us access to a wealth of data and practical knowledge. We translate this knowledge into practical products that have real added value for the client. We specialise in research and recognition of all diseases, plagues and weeds that effect arable crops, flower bulbs, field vegetable crops, tree nurseries and sports fields. An important specialisation in our portfolio is research in the field of quarantine organisms. Our professional quarantine laboratory and our quality assurance system make us unique in this field. HLB aims to contribute to furthering efficient and sustainable agriculture by performing excellent research and practical diagnoses and providing the right advice with demonstrable added value for the agri-chain. The agriculture and horticulture sector holds the key to the challenge of meeting the increasing demand for sustainable food and clean water all over the world. HLB is making its contribution by stimulating efficient and sustainable practices in this sector. We achieve this by conducting in-depth research and providing diagnoses and practical advice with a demonstrable added value for the agri-chain. This is how we make the latest knowledge on sustainability useful and effective for the farmer and horticulturist.

Hemoteq

Würselen, NRW, 52146 GermanyHemoteq is the leading designer and manufacturer of customized coatings for medical devices. Our innovative surface solutions create a sustainable competitive advantage for our clients.

HaemoScan

Stavangerweg 23-23 Groningen, 9723 JC NetherlandsComplement assays are one of the specialties of Haemoscan. Haemoscan aspires efficiency and flexibility and distinguishes itself by offering more than standard testing. We think along with our clients to improve further development.

IATEC

Petersburgweg 9 Amstedarm 1105 NetherlandsIATEC provides clinical trial services, antiviral research, and consulting.

Isogen Life Science

Veldzigt 2a, De Meern, 3454 PW The NetherlandsIsogen Life Science provides a wide range of instruments, reagents and consumables in the areas of cell biology, molecular biology and biochemistry

Innoventis

NetherlandsInnoventis is an independent organization that conducts research into fertilizer, pesticides, biological applications and demo races for national and international manufacturers and suppliers in agriculture, bulbs, outdoor vegetables and crops under glass. Also, research is done to damage caused by wild weather and errors in the application of products.

Ingress Health

Weena 316-318 Rotterdam, 3012 NJ NetherlandsIngress-Health is a fast-growing European health-care consultancy with offices in Wismar, Germany and Rotterdam, Netherlands. We have years of experience and profound knowledge in health economics and outcomes research. Our core services focus on: • Real-World Evidence (RWE) Studies, • Strategic Market Access & Health Policy Communication, • Evidence Synthesis, and • Health-Economic Modelling. At Ingress health, we strongly believe that the future of health technology reimbursement in the EU will be based on flexible pricing systems and or provisional reimbursement with corresponding outcomes-based managed entry schemes and health economic evaluations. This belief is based on trends in digitalization of patient outcomes in clinical practice, the increasing number of drugs approved with conditional market authorization by EMA, and an increase in outcomes based managed entry schemes in the EU. This shift from reimbursement to conditional reimbursement requires a change of mindset in the industry as in the past, when developing Real-World Evidence studies, manufacturers often did not (need to) consider the health economic perspective. Ingress health team also strongly believes that a lot of products are underutilized because clinical trials did not show their value in terms of e.g. reduced side effects, improved quality of life and or compliance. Therefore, Ingress health was founded February 1st 2015. With Ingress health’s combined and integrated health economic and Real-World Evidence expertise and passion for the field, we feel that Ingress health team will be successful in optimizing your products pre and post-marketing value proposition. OUR VALUES Ingress health team is sincerely curious about our clients, the context of the project and about the product. We are thorough in everything we do. Regarding the project, we at Ingress health will consider several different angles before presenting the final result and or approach. Ingress health team is confident that we can produce high quality timely results, as such we do offer project pay per performance schemes. With Ingress health combined Real-World Evidence and health economic expertise, we are confident that we can find the unexplored value of your product.

INTEGREX Research

Kadijk 3 9747 AT GRONINGEN The NetherlandsINTEGREX Research is a combination of long standing contract research experience and seasoned drug discovery expertise obtained in pharmaceutical industry. INTEGREX Research offers Integrated Drug Discovery Service in the range of hit finding up to pre-clinical candidate selection.

IQ Products

Rozenburglaan 13a Groningen, 9727 DL NetherlandsIQ Products supplies reagents and kits in application of flow cytometry, ELISA, hematology, and fluorescence microscopy in addition to offering custom antibody development services.

Intravacc

9 Antonie van Leeuwenhoeklaan, Bilthoven, UT 3721 MA, NLLooking for a partner to develop or improve your vaccine technology? Intravacc, the Institute for Translational Vaccinology, is an experienced, not-for-profit R&D organization. We optimize vaccines, vaccine processes and vaccine technologies. In our state-of-the-art facilities, our experienced R&D institute takes your discovery up to Phase I/II clinical trials. Furthermore, we share and transfer our knowledge and technologies to public and private partners worldwide and work on collaborative R&D. Laboratory area 3500 m² BSL2, BSL3 & GMP facilities; Animal Research Center; Lab- & pilot-scale production capabilities (using glass, stainless steel, and disposable bioreactor technologies); Upstream Processing (USP) and Downstream Processing (DSP); Experience in bio safety (BSL2) and containment; Advanced analytical capabilities (including: MS, NMR, HPLC, FACS, Biacore, etc.); Design-of-Experiments (DoE) expertise, including scale-up and scale-down models for all unit operations; Mathematical model development & cost-of-goods calculations.

InSight Pathology BV

Chopinlaan 6 5343EM Oss The NetherlandsInSight Pathology is a privately owned company located in the south-east of the Netherlands, offering services related to toxicologic pathology. With more than 30 years of experience in the pharmaceutical and chemical industry, a broad range of challenges in the field of toxicological pathology have been addressed and have strengthened our knowledge, experience, capability and insight. Straightforward studies and interpretations of toxicology issues rarely exist and bespoke solutions are often required. It is therefore a benefit to realize that InSight Pathology has the expertise to support you with these studies, by slide reading and peer reviews on the one hand and consultancy on the other. InSight Pathology can perform slide reading for your studies and the interpretation of findings in these studies. Slide reading for GLP as well as non-GLP studies can be performed. InSight Pathology uses the PathData System for entry and evaluation of pathology data resulting from toxicity and carcinogenicity studies. InSight Pathology has experience in a broad range of studies, varying from short term to carcinogenicity studies, and from studies in rodents (including transgenic animals) to studies in non-human primates, using different routes of administration. In addition, many different compounds and chemicals from a wide range of therapeutic areas have been assessed. Besides slide reading for your studies, InSight Pathology can also coordinate the peer-review process for your studies. InSight Pathology can provide you with advice on all issues related to toxicological pathology. To be able to give valuable advice, experience is key. As said, with more than 30 years of experience in the pharmaceutical and chemical industry a broad range of challenges in toxicological pathology have been faced. With this background, InSight Pathology is confident to be able to advise on the way forward for your project (when pathology is concerned), to advise on follow up activities when certain findings are difficult to interpret or make an overall interpretation of pathology findings over different studies. InSight Pathology could also help you in your Due Diligence preparation, when an in-depth evaluation of the toxicological pathology part is needed.

InSight Pathology BV

6 Chopinlaan Oss, NB, 5343 EM NetherlandsInSight Pathology is a privately owned company located in the south-east of the Netherlands, offering services related to toxicologic pathology. With more than 30 years of experience in the pharmaceutical and chemical industry, a broad range of challenges in the field of toxicological pathology have been addressed and have strengthened our knowledge, experience, capability and insight. Straightforward studies and interpretations of toxicology issues rarely exist and bespoke solutions are often required. It is therefore a benefit to realize that InSight Pathology has the expertise to support you with these studies, by slide reading and peer reviews on the one hand and consultancy on the other. InSight Pathology can perform slide reading for your studies and the interpretation of findings in these studies. Slide reading for GLP as well as non-GLP studies can be performed. InSight Pathology uses the PathData System for entry and evaluation of pathology data resulting from toxicity and carcinogenicity studies. InSight Pathology has experience in a broad range of studies, varying from short term to carcinogenicity studies, and from studies in rodents (including transgenic animals) to studies in non-human primates, using different routes of administration. In addition, many different compounds and chemicals from a wide range of therapeutic areas have been assessed. Besides slide reading for your studies, InSight Pathology can also coordinate the peer-review process for your studies. InSight Pathology can provide you with advice on all issues related to toxicological pathology. To be able to give valuable advice, experience is key. As said, with more than 30 years of experience in the pharmaceutical and chemical industry a broad range of challenges in toxicological pathology have been faced. With this background, InSight Pathology is confident to be able to advise on the way forward for your project (when pathology is concerned), to advise on follow up activities when certain findings are difficult to interpret or make an overall interpretation of pathology findings over different studies. InSight Pathology could also help you in your Due Diligence preparation, when an in-depth evaluation of the toxicological pathology part is needed.

IBIS Technologies B.V.

Pantheon 5 7521 PR Enschede The NetherlandsAt IBIS, we want our customers to achieve the highest level of excellence when performing SPR measurements. To that end, we can provide you with detailed information on the physics of SPR, scientific papers, whitepapers to explain applications, instructional videos and more.

Institute for Risk Assessment Sciences

Utrecht University PO Box 80.177 3508 TD Utrecht The NetherlandsInstitute for Risk Assessment Sciences provides toxicology and epidemiology.

Alpha Packaging International

Bijsterhuizen 1009 NL - 6604 LA Wijchen The NetherlandsAlpha Packaging International offers a wide variety of closures and other packaging materials.

IDEXX

Scorpius 60 Building F Hoofddorp, 2132 LR The NetherlandsIDEXX BioAnalytics is the premier reference lab partner providing central laboratory services (Haematology, Biochemistry, Immunology, Parasitology, Microbiology, etc.) and Point of Care tests to support pharma, biotech, pet food, and academia's clinical (GCP) and preclinical veterinary studies in Europe and North America. In addition, IDEXX BioAnalytics offers expert support in toxicology Histology (GLP). IDEXX BioAnalytics provides quality veterinary research analyzers, which can also be installed to GLP standards, for preclinical and clinical research. IDEXX BioAnalytics 's team has developed nearly all the newest technologies in the field of research animal health monitoring, including all new techniques to help Replace, Reduce and Refine animal testing. IDEXX BioAnalytics provides a biological testing service for independent confirmation of quality, safety, and authenticity of biological materials.

Institute for Biodynamics and Biocomplexity

Utrecht University Padualaan 8, 3584 CH, Utrecht The NetherlandsBiology Imaging Center provides access, support and training in advanced light and fluorescent microscopy techniques for research groups within the department of Biology and also to groups from other institutes within and outside Utrecht.

Institute for Biodynamics and Biocomplexity

C.H. Letschertweg Utrecht, UT, 3545 NetherlandsBiology Imaging Center provides access, support and training in advanced light and fluorescent microscopy techniques for research groups within the department of Biology and also to groups from other institutes within and outside Utrecht.

Interchemie

Metaalweg 8 5804 CG Venray The NetherlandsInterchemie manufactures veterinary products, supplies, pharmaceuticals, drugs and medicines.

Interchemie

Venray, LI NetherlandsInterchemie manufactures veterinary products, supplies, pharmaceuticals, drugs and medicines.

IBL International

Zutphenseweg 55 7418 AH Deventer The NetherlandsIBL International offers reagents, antibodies, and assay kit products for purchase.

IPA (ImmunoPrecise Antibodies)

Life Sciences Incubator Yalelaan 62 Utrecht CM, 3584 NetherlandsProprietary Technologies Developed for Your Success ImmunoPrecise Antibodies (IPA) accelerates therapeutic antibody discovery by offering a full suite of innovative technologies yielding superior candidate diversity and out-performing traditional methods. Immunization: • DNA, protein, peptide, whole cell immunization • Proprietary immunization methods, including rapid protocols • Species include mouse, rat, camelid, rabbit, chicken, goat, more... • Proven success with multiple transgenic species/strains Antibody Discovery: • Expedited discovery through our superior B cell selection technology • Advanced custom and in-house phage library screening • Human and naïve llama libraries (VHH and scFv) available • Rodent and rabbit monoclonal development • State-of-the-art hybridoma generation, including semi-solid media and clone picking Completing the Full Value Chain: • Characterization • Engineering and humanization • Optimization • Bi-specifics development and manufacturing • Recombinant protein manufacturing • Pre-clinical studies

IPA (ImmunoPrecise Antibodies)

Building OP Kloosterstraat 9 Oss, AB, 5349 NetherlandsProprietary Technologies Developed for Your Success ImmunoPrecise Antibodies (IPA) accelerates therapeutic antibody discovery by offering a full suite of innovative technologies yielding superior candidate diversity and out-performing traditional methods. Immunization: • DNA, protein, peptide, whole cell immunization • Proprietary immunization methods, including rapid protocols • Species include mouse, rat, camelid, rabbit, chicken, goat, more... • Proven success with multiple transgenic species/strains Antibody Discovery: • Expedited discovery through our superior B cell selection technology • Advanced custom and in-house phage library screening • Human and naïve llama libraries (VHH and scFv) available • Rodent and rabbit monoclonal development • State-of-the-art hybridoma generation, including semi-solid media and clone picking Completing the Full Value Chain: • Characterization • Engineering and humanization • Optimization • Bi-specifics development and manufacturing • Recombinant protein manufacturing • Pre-clinical studies

ISOTRON NEDERLAND BV

6 De Meerheuvel 's-Hertogenbosch, NB, 5221 EA NetherlandsIsotron Systems supplies advanced industrial automation products and components. This means delivering high tech and knowledge based specific applications and solutions to many industrial branches and market segments.

Julius Clinical

Broederplein 41-43 3703 CD Zeist NetherlandsJulius Clinical is a unique academic research organization (ARO) that combines strong scientific leadership and operational excellence to conduct innovative national and global clinical trials. The Julius Center was itself founded in 1996, after the merger of the UMC’s departments of Epidemiology and Public Health with Clinical Epidemiology. Overall, the centre contains a wealth of expertise in the disciplines of epidemiology, public health, general practice, biostatistics, and medical technology assessment. Since its establishment, the Julius Center has been actively involved in the design, conduct, and reporting of groundbreaking phase IIB-IV clinical trials in Europe, in the fields of cardiovascular disease, infectious disease, oncology, genetics, and mental health.

Kinesis Pharma

Lage Mosten 29Kinesis Pharma provides non-clinical and clinical development, pharmacokinetics, and formulation development.

Keygene

Agro Business Park 90 6708 PW Wageningen The NetherlandsKeygene provides contract research for the plant breeding industry, partnerships, and molecular genetic services.

Kreatech Diagnostics

Vlierweg 20Kreatech Diagnostics provides molecular diagnostics, protein science, array services, labeling services, hybridization, and research products.

Koppert Biological Systems

Veilingweg 14 2651 BE Berkel en Rodenrijs The NetherlandsKoppert Biological Systems contributes to better health of people and the planet. In partnership with nature, we make agriculture healthier, safer and more productive. We provide an integrated system of specialist knowledge and natural, safe solutions that improves crop health, resilience and production.

Kiadis

Entrada 231-234Kiadis provides natural products and clinical trial services.

LAP&P Consultants (Leiden Advanced Pharmacokinetics & Pharmacodynamics)

Archimedesweg 31 Leiden, ZH, 2333 CM NetherlandsLAP&P Consultants provides pharmacokinetics (PK) and pharmacodynamics (PD) modelling and simulation services.

LabVantage

Lichtenauerlaan 102-120LabVantage provides software solutions for laboratory management.

Lucron ELITechGroup

Postbus 100, 6950 AC Dieren, The NetherlandsLucron ELITechGroup offers premium quality diagnostic products and research supplies to laboratories in the entire Benelux area: Belgium, the Netherlands and Luxembourg.

LINGE AGROCONSULTANCY

Oosterhoutsestraat 95 6678 PG Oosterhout (Gld) The NetherlandsLinge Agroconsultancy is an independent consulting company specialised in supporting the registration of both chemical and biological crop protection products. Since 2003, Linge Agroconsultancy acts as an evaluating authority, concerning efficacy, for the Dutch authorisation board. We have the expertise to guide you through the entire registration process of crop protection products. We carry out assignments for both the government and trade and industry. Linge Agroconsultancy takes care of your regulatory needs and provides you with tailor-made advice. We have short lines of communication and work customer-oriented. Confidentiality is, of course, guaranteed.

Lonza

Louis Pasteurweg 1 ROERMOND, 6045 GW NetherlandsLonza provides advanced cell biology and cell engineering solutions that support customers from discovery to the clinic. We provide primary human cells, specialized media, advanced cell culture and transfection tools, supported by best-in-class quality, regulatory and scientific support. We support customers from basic research through preclinical and process development stages of small molecules, biologics, and cell and gene therapy programs in drug discovery and immuno-oncology. This includes immunogenicity prediction and assessment, manufacturability risk assessment and protein re-engineering.

Lonza

Aluminiumstraat 1, Breda, 4823 AL, The NetherlandsLonza provides advanced cell biology and cell engineering solutions that support customers from discovery to the clinic. We provide primary human cells, specialized media, advanced cell culture and transfection tools, supported by best-in-class quality, regulatory and scientific support. We support customers from basic research through preclinical and process development stages of small molecules, biologics, and cell and gene therapy programs in drug discovery and immuno-oncology. This includes immunogenicity prediction and assessment, manufacturability risk assessment and protein re-engineering.

LIPOSOMA research & manufacturing

Meerpaalweg 5 Almere, Noord-Holland, 1332 BB NetherlandsLIPOSOMA is a liposome and nanoparticle service company based in the Netherlands. LIPOSOMA distinguishes itself by providing both high standard R&D services and contract manufacturing. Our team consists of world leading scientists capable of engineering a wide range of liposomes and other lipid based nano particles, containing the most complex compounds. Our services are provided with state of the art equipment, in our laboratories at Science Park Amsterdam and our large scale production facility in Almere. We provide custom formulation services, feasibility studies, preparation, formulation characterization, manufacturing, and quality control. LIPOSOMA has provided a wide variety of services to the pharmaceutical, biotech, life science, chemical, cosmetic, dietary supplement and food industries with our commitment to scientific excellence.

Leiden University Medical Center

Albinusdreef 2 Netherlands Leiden, 2333ZA NetherlandsLeiden University Medical Center offers research services in the fields of malaria, cellular immunology, glycobiology, and epidemiology.

Lumicks B.V.

De Boelelaan 1085, W&N Gebouw, Kamer H226 Nederland Amsterdam, Nederland, 1081 HV NetherlandsLUMICKS is a next-generation life science tools company focused on enabling more efficient research, drug development, bioprocessing, bioproduction quality control, and patient treatment. For the first time ever, our unapparelled solutions can assist research by directly linking structural and ‘omics analysis to functional outcomes at both a molecular and a cellular level. This is achieved by applying and measuring forces around biological interactions, enabling the detailed real-time analysis of underlying biological mechanisms. We have leveraged our deep biophysics expertise to develop differentiated technologies that are designed to drive new and faster innovations. Our products utilize our proprietary dynamic single-molecule (DSM) analysis and cell-binding avidity (CA) analysis technologies.

Leiden University Medical Center Center for Proteomics and Metabolomics

Center for Proteomics and Metabolomics Albinusdreef 2 Leiden, 2333ZA NetherlandsThe Center for Proteomics and Metabolomics (CPM) forms the main expertise center and technology focus area for (clinical) proteomics and metabolomics in the LUMC. The key technologies are liquid separations (liquid chromatography and capillary electrophoresis), gas chromatography, mass spectrometry (MS) and nuclear magnetic resonance (NMR). Our main field of expertise is the application of these technologies in clinical research. The Center houses over 30 state-of-the-art mass spectrometers ranging from triple-quadrupole and ion trap instruments to time-of-flight and Fourier transform mass spectrometers. Most of the instruments are coupled on-line (electrospray ionization, ESI) or off-line (matrix assisted laser desorption/ionization, MALDI) to liquid separations. The MALDI instruments are used for high-throughput screening and imaging mass spectrometry, whereas the ESI mass spectrometers are used in a wide range of proteomics and metabolomics research projects for identification and quantitation of proteins, peptides and small molecules.

Leiden University Medical Center Center for Proteomics and Metabolomics

Zone S3 Albinusdreef 2 2333 ZA Leiden The NetherlandsThe Center for Proteomics and Metabolomics (CPM) forms the main expertise center and technology focus area for (clinical) proteomics and metabolomics in the LUMC. The key technologies are liquid separations (liquid chromatography and capillary electrophoresis), gas chromatography, mass spectrometry (MS) and nuclear magnetic resonance (NMR). Our main field of expertise is the application of these technologies in clinical research. The Center houses over 30 state-of-the-art mass spectrometers ranging from triple-quadrupole and ion trap instruments to time-of-flight and Fourier transform mass spectrometers. Most of the instruments are coupled on-line (electrospray ionization, ESI) or off-line (matrix assisted laser desorption/ionization, MALDI) to liquid separations. The MALDI instruments are used for high-throughput screening and imaging mass spectrometry, whereas the ESI mass spectrometers are used in a wide range of proteomics and metabolomics research projects for identification and quantitation of proteins, peptides and small molecules.

Leiden University Medical Center Center for Proteomics and Metabolomics

Zone S3 Albinusdreef 2 Leiden, 2333 ZA NetherlandsThe Center for Proteomics and Metabolomics (CPM) forms the main expertise center and technology focus area for (clinical) proteomics and metabolomics in the LUMC. The key technologies are liquid separations (liquid chromatography and capillary electrophoresis), gas chromatography, mass spectrometry (MS) and nuclear magnetic resonance (NMR). Our main field of expertise is the application of these technologies in clinical research. The Center houses over 30 state-of-the-art mass spectrometers ranging from triple-quadrupole and ion trap instruments to time-of-flight and Fourier transform mass spectrometers. Most of the instruments are coupled on-line (electrospray ionization, ESI) or off-line (matrix assisted laser desorption/ionization, MALDI) to liquid separations. The MALDI instruments are used for high-throughput screening and imaging mass spectrometry, whereas the ESI mass spectrometers are used in a wide range of proteomics and metabolomics research projects for identification and quantitation of proteins, peptides and small molecules.

Luminex

Krombraak 13-15Luminex provides expression profiling, genomic research, immunodiagnostics, and genetic disease studies. LuminexPLORE Lab is a custom services program that uses industry-leading xMAP technology to offer researchers a competitive edge for scientific breakthroughs. Luminex's team of Applications Scientists are experts in immunoassay and genomic assay development using xMAP and xTAG technologies. Our technologies currently serve a vast community of researchers and scientists with their own custom needs. Whether you are a new assay developer or trying to accelerate your project, LuminexPLORE Lab can help your lab reach its goals faster.

Lambert Instruments BV

5th floor, Leonard Springerlaan 19 9727KB Groningen The NetherlandsLambert Instruments was founded by Bert van Geest in 1992, who wanted to apply his knowledge of image intensifiers. He started to use image intensifiers in CCD cameras that had to be very sensitive to light and that are used in scientific applications. Intensified CCD cameras have been delivered to many institutes that are active in fields like biomedical research, astronomy and experimental physics. Special medical cameras have been developed for the analysis of the vocal cords. Imaging products from other manufacturers have been added to the product range or are integrated in systems for imaging at low light level and/or high-speed. Besides a range of standard products also custom-made products are offered. Our procedure: Analyse your problem Propose possible solutions and options Discuss the difference in price and performance. Create the most effective solution Based on the final specification the order is executed against the agreed price and delivery time. This way you will be assured of a well-defined product that fits budget and planning. According to this procedure many projects have been successfully completed for various customers. Mission Statement Lambert Instruments' mission is to develop, produce and market high-end products for time-resolved imaging at low light levels guided by customer feedback. By continuously watching the latest technological developments and looking for opportunities to apply these in existing and new products, highly qualified people make sure your wishes get the best possible attention. Lambert Instruments is dedicated to development, production and worldwide sales of products for imaging at low light levels. Please do contact us for more information and for advice regarding your imaging needs.

Lambert Instruments BV

5th floor, Leonard Springerlaan 19 Groningen, 9727KB NetherlandsLambert Instruments was founded by Bert van Geest in 1992, who wanted to apply his knowledge of image intensifiers. He started to use image intensifiers in CCD cameras that had to be very sensitive to light and that are used in scientific applications. Intensified CCD cameras have been delivered to many institutes that are active in fields like biomedical research, astronomy and experimental physics. Special medical cameras have been developed for the analysis of the vocal cords. Imaging products from other manufacturers have been added to the product range or are integrated in systems for imaging at low light level and/or high-speed. Besides a range of standard products also custom-made products are offered. Our procedure: Analyse your problem Propose possible solutions and options Discuss the difference in price and performance. Create the most effective solution Based on the final specification the order is executed against the agreed price and delivery time. This way you will be assured of a well-defined product that fits budget and planning. According to this procedure many projects have been successfully completed for various customers. Mission Statement Lambert Instruments' mission is to develop, produce and market high-end products for time-resolved imaging at low light levels guided by customer feedback. By continuously watching the latest technological developments and looking for opportunities to apply these in existing and new products, highly qualified people make sure your wishes get the best possible attention. Lambert Instruments is dedicated to development, production and worldwide sales of products for imaging at low light levels. Please do contact us for more information and for advice regarding your imaging needs.

Leiden University Medical Center - Leiden Genome Technology Center

Albinusdreef 2 Leiden, 2333 ZA NetherlandsThe Leiden Genome Technology Center is the genomics core facility of the Leiden University Medical Center. We offer single-cell and single-molecule sequencing on a fee-for-service basis.

MagnaMedics

Burg. Lemmensstraat 366 6163 JT Geleen (The Netherlands)MagnaMedics offers in vitro diagnostics, medical imaging and drug delivery products.

Mouse Clinic for Cancer and Aging - MCCA

Antonius Deusinglaan 1 9713 AV Groningen The NetherlandsThe aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA will accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases. The MCCA houses three key expertises: A Transgenic facility for efficient derivation, genetic modification and distribution of embryonic stem cell (ESC) lines from GEMMs, and for production of ESC-derived mice. A Mouse Cancer Clinic for preclinical intervention studies and imaging of cancer growth and therapy response in advanced mouse models of human cancer. An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, and for creating a centralized biobank of frozen mouse tissues for aging research. The MCCA is partner of the EC funded Infrafrontier Project for the implementation of a sustainable European research infrastructure for systemic phenotyping, archiving and distribution of mouse models. The MCCA is also the National partner of the European Mouse Mutant Archive (EMMA) for distribution of GEMM-derived ESC lines via the Infrafrontier portal.

Mouse Clinic for Cancer and Aging - MCCA

Plesmanlaan 121 1066 CX Amsterdam The NetherlandsThe aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA will accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases. The MCCA houses three key expertises: A Transgenic facility for efficient derivation, genetic modification and distribution of embryonic stem cell (ESC) lines from GEMMs, and for production of ESC-derived mice. A Mouse Cancer Clinic for preclinical intervention studies and imaging of cancer growth and therapy response in advanced mouse models of human cancer. An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, and for creating a centralized biobank of frozen mouse tissues for aging research. The MCCA is partner of the EC funded Infrafrontier Project for the implementation of a sustainable European research infrastructure for systemic phenotyping, archiving and distribution of mouse models. The MCCA is also the National partner of the European Mouse Mutant Archive (EMMA) for distribution of GEMM-derived ESC lines via the Infrafrontier portal.

Mouse Clinic for Cancer and Aging - MCCA

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsThe aging population in developed countries leads to rapid increase in cancer incidence and other aging-related disorders. To accelerate cancer and aging research and to contribute to the theme of ‘healthy aging’, the Netherlands Cancer Institute (NKI) and the European Research Institute for the Biology of Aging (ERIBA) have established a Mouse Clinic for Cancer and Aging research (MCCA). The MCCA will accelerate the development of genetically engineered mouse models (GEMMs) of human cancer and aging syndromes. These mouse models will be used for developing new therapies against cancer and aging-related diseases. The MCCA houses three key expertises: A Transgenic facility for efficient derivation, genetic modification and distribution of embryonic stem cell (ESC) lines from GEMMs, and for production of ESC-derived mice. A Mouse Cancer Clinic for preclinical intervention studies and imaging of cancer growth and therapy response in advanced mouse models of human cancer. An Aging and Phenotyping Facility for controlled aging and phenotyping studies in different inbred mouse strains and GEMMs, and for creating a centralized biobank of frozen mouse tissues for aging research. The MCCA is partner of the EC funded Infrafrontier Project for the implementation of a sustainable European research infrastructure for systemic phenotyping, archiving and distribution of mouse models. The MCCA is also the National partner of the European Mouse Mutant Archive (EMMA) for distribution of GEMM-derived ESC lines via the Infrafrontier portal.

MolMo Services

Pastorijstraat 11MolMo Services offers targeted library design, high throughput screening, in silico screening, docking, structure based screening, and API services.

Medpace

Rivium Boulevard 102b, 2909 LK Capelle Aan Den IJssel / Rotterdam, NetherlandsMedpace is a Full Service CRO and offers clinical development services including medical writings, biometrics, regulatory affairs and quality assurance. Also offered are Central Lab Services, Bio-Analytical, Biomarker Testing, BioSample Storage and Management, Long-term BioRepository, Core Lab Services, Imaging, and a Phase I Safety Clinic.

Medpace

Rivium Boulevard 102b, 2909 LK Capelle Aan Den IJssel / Rotterdam NetherlandsMedpace is a Full Service CRO and offers clinical development services including medical writings, biometrics, regulatory affairs and quality assurance. Also offered are Central Lab Services, Bio-Analytical, Biomarker Testing, BioSample Storage and Management, Long-term BioRepository, Core Lab Services, Imaging, and a Phase I Safety Clinic.

MPF

MPF bv P.O. Box 570 8440 AN Heerenveen NetherlandsMPF is an independent pharmaceutical contract-manufacturer.

MPF

Appelhof 13 8465 RX Oudehaske NetherlandsMPF is an independent pharmaceutical contract-manufacturer.

MiPlaza Materials Analysis

High Tech Campus 11 room p309

MiPlaza Materials Analysis

11 High Tech Campus Eindhoven, NB, 5656 AE Netherlands

MYMETICS BV

21 J.H. Oortweg, Leiden, ZH 2333 CH, NLMYMETICS: THE POWER OF A UNIQUE TECHNOLOGY TO DEVELOP NEXT-GENERATION PROPHYLACTIC VACCINES FOR INFECTIOUS DISEASES Our vaccines are designed to induce protection against early transmission and infection, focusing both on the mucosal immune response as a first-line defense and the systemic humoral (blood) immune response, which, for some pathogens, may be essential for the development of an effective prophylactic vaccine. Our unique approach has resulted in the development of a rich pipeline of 5 vaccine candidates for HIV-1/AIDS, intra nasal Influenza, Malaria, Herpes Simplex Virus (HSV) and the Respiratory Syncytial Virus (RSV) vaccine. Our delivery platform is being validated through partnership with leading pharmaceutical or research organisations, including Astellas Pharma, PATH-MVI and the Bill and Melinda Gates Foundation. Mymetics Corporation (OTCQB: MYMX) is a Swiss based biotechnology company, with a Research Lab in the Netherlands. The company is registered in the US and trades on the OTCQB.

Molecular Modeling and Drug Design (MMDD)

Dr. M.R. de JongeMolecular Modeling and Drug Design (MMDD) is a consultancy and service company with strong expertise in molecular modeling, computational chemistry, classical rational drug design, de novo drug design, and virtual screening.

MAT BioTech B.V.

Handelswei 1 Joure, 8501 XJ NetherlandsWith an LoD of 0.004 EU/ml and batch sizes of up to 2,000 kits, MAT BioTech's Monocyte Activation Test (MAT) kit helps big pharmaceuticals develop and release life changing products, safer than ever before. Our MAT kits are produced, and design controlled, to align with relevant ISO 13485 standards.

MAT BioTech B.V.

Hollandse Kade 32-33 Abcoude, Utrecht, 1391 JM NetherlandsWith an LoD of 0.004 EU/ml and batch sizes of up to 2,000 kits, MAT BioTech's Monocyte Activation Test (MAT) kit helps big pharmaceuticals develop and release life changing products, safer than ever before. Our MAT kits are produced, and design controlled, to align with relevant ISO 13485 standards.

MBF Europe

Nieuwe Plantage 28 Delft, 2611 XJ NetherlandsWe design quantitative imaging software for stereology, neuron reconstruction, and image analysis, integrated with the world’s leading microscope systems, to empower your research. Our development team and staff scientists are actively engaged with leading bioscience researchers, constantly working to refine our products based on your feedback and scientific advances in the field. Whether you are interested in design-based stereology, neuron reconstruction, brain mapping, virtual slides, autoradiography, or worm tracking, you can be confident that our products include the most current protocols available to keep you on the cutting edge with accurate results. Founded as MicroBrightField, Inc. in 1988, we changed our name to MBF Bioscience in 2005, as part of our efforts to demonstrate that our product and service offerings have broadened. While we specialize in neuroscience research, our products are also used extensively in stem cell research, lung, kidney, reproductive, cardiac, and toxicology research. Our software allows you to easily obtain accurate quantitative measurements from microscope images, whether from brightfield, fluorescent, spinning disk, or laser-scanning confocal microscopes, and we back up our products with a support team that is world-renowned for its dedication to keeping customers productive.

Merge Healthcare

De Zaale 11 (Twinning Center) 5612 AJ Eindhoven The NetherlandsMerge Healthcare specializes in clinical systems and offers cloud-based solutions for imaging and data analytics.

Mimetas B.V.

De Limes 7 Oegstgeest, Zuid-Holland, 2342DH NetherlandsMimetas develops human tissue and disease models for better therapies in OrganoPlates®. We all want better medicines, that’s obvious. To make this possible, you need better disease models. They should be fully human and physiologically relevant. Truly informative tools, compatible with compounds and with your high-throughput readout equipment. And of course you need them today, rather than tomorrow. A dream? Not anymore. As true pioneers in organ-on-a-chip biology, MIMETAS is proud to offer high-throughput human tissue and disease models in OrganoPlates®. OrganoPlates® are microfluidic 3D culture plates, supporting up to 96 tissue models on a single plate. OrganoPlates® contain Phaseguides, a proprietary, passive liquid handling technology for membrane-free definition of tissues in microfluidic chambers. OrganoPlates® are based on the industry-standard 384-well plate for full compatibility with liquid handling- and readout equipment. Within the plate, cells are contained in a gel, supporting 3D tissue configurations and cell-cell interactions. A continuous perfusion of media through the plate mimics blood flux and exchange of nutrients, oxygen and metabolites. The plates are versatile, supporting chemical gradients and co-culture conditions. In this way, complex tissue models can be implemented in a straightforward way.

Mimetas B.V.

JH Oortweg 19 Leiden, Zuid-Holland, 2333 CH NetherlandsMimetas develops human tissue and disease models for better therapies in OrganoPlates®. We all want better medicines, that’s obvious. To make this possible, you need better disease models. They should be fully human and physiologically relevant. Truly informative tools, compatible with compounds and with your high-throughput readout equipment. And of course you need them today, rather than tomorrow. A dream? Not anymore. As true pioneers in organ-on-a-chip biology, MIMETAS is proud to offer high-throughput human tissue and disease models in OrganoPlates®. OrganoPlates® are microfluidic 3D culture plates, supporting up to 96 tissue models on a single plate. OrganoPlates® contain Phaseguides, a proprietary, passive liquid handling technology for membrane-free definition of tissues in microfluidic chambers. OrganoPlates® are based on the industry-standard 384-well plate for full compatibility with liquid handling- and readout equipment. Within the plate, cells are contained in a gel, supporting 3D tissue configurations and cell-cell interactions. A continuous perfusion of media through the plate mimics blood flux and exchange of nutrients, oxygen and metabolites. The plates are versatile, supporting chemical gradients and co-culture conditions. In this way, complex tissue models can be implemented in a straightforward way.

Microbome Diagnostics

Troubadour Borch 59 3992 BE Houten NetherlandsMicrobiome is a company that specializes in the field of innovative molecular microbiological detection techniques for infectious diseases and specializes in the development and implementation of molecular analyzes for complex microbial niches.

Macrogen Europe B.V.

Meibergdreef 31 Amsterdam, 1105 AZ NetherlandsMacrogen, a leading company in precision medicine and biotechnology, was established on June 5, 1997 based on the Genomic Medicine Institute of the Seoul National University College of Medicine. In February 2000, Macrogen became the first ever bio venture in Korea to be listed on the KOSDAQ. Since then, Macrogen has continued to be actively engaged in R&D fields of genetic and genomic analyses. Today, Macrogen has become a global expert in genomic analysis and a leader in Korean biotechnology, working closely with over 18,000 research clients across 153 countries worldwide. In addition to providing services to clients all over the world, Macrogen contributes to the advancement of bioindustries through a wide range of R&D and CSR activities.

Macrogen Europe B.V.

Meibergdreef 57 Amsterdam, 1105BA NetherlandsMacrogen, a leading company in precision medicine and biotechnology, was established on June 5, 1997 based on the Genomic Medicine Institute of the Seoul National University College of Medicine. In February 2000, Macrogen became the first ever bio venture in Korea to be listed on the KOSDAQ. Since then, Macrogen has continued to be actively engaged in R&D fields of genetic and genomic analyses. Today, Macrogen has become a global expert in genomic analysis and a leader in Korean biotechnology, working closely with over 18,000 research clients across 153 countries worldwide. In addition to providing services to clients all over the world, Macrogen contributes to the advancement of bioindustries through a wide range of R&D and CSR activities.

Macrogen Europe B.V.

Meibergdreef 31, 1105 AZ Amsterdam Amsterdam, ---, 1105 NetherlandsMacrogen, a leading company in precision medicine and biotechnology, was established on June 5, 1997 based on the Genomic Medicine Institute of the Seoul National University College of Medicine. In February 2000, Macrogen became the first ever bio venture in Korea to be listed on the KOSDAQ. Since then, Macrogen has continued to be actively engaged in R&D fields of genetic and genomic analyses. Today, Macrogen has become a global expert in genomic analysis and a leader in Korean biotechnology, working closely with over 18,000 research clients across 153 countries worldwide. In addition to providing services to clients all over the world, Macrogen contributes to the advancement of bioindustries through a wide range of R&D and CSR activities.

MAT Research

J.H. Oortweg 21 LEIDEN, Zuid-Holland, 2333 CH NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

MAT Research

Zeeburgerpad 5 Amsterdam, AH, 1018 NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

MAT Research

Zeeburgerpad 5 Amsterdam, AH, 1018 NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

MAT Research

Zeeburgerpad 5 Amsterdam, AH, 1018 NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

MAT Research

Zeeburgerpad 5 Amsterdam, AH, 1018 NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

MAT Research

Zeeburgerpad 5 Amsterdam, Noord Holland, 1018AH NetherlandsNext-generation Monocyte Activation Test (MAT) for pyrogen and endotoxin technology and services. Our MAT uses cryopreserved (pooled or single donor) PBMC for both the highest sensitivity (LoD of 0.004 EU/ml) and robustness, ensuring reliability in the field. We deliver preconfigured kits, independent components, and bespoke custom production of MAT tests. Our in-house science consulting department can also support research and optimizing the MAT for your product. Our MAT kits are designed and produced in alignment with ISO 9001:2015 standard for use in ISO13485 environments.

Meelunie

Vinoly Tower, 18th Floor Claude Debussylaan 40 1082 MD AmsterdamMeelunie is a global supplier of agricultural ingredients.

Netherlands Metabolomics Centre

Catharijnesingel 54 3511 GC Utrecht The NetherlandsThe Netherlands Metabolomics Centre (NMC) brings together the vast knowledge and extensive expertise of the Dutch genomics and life sciences community to develop the technologies that will meet these demands. Through active community building and collaboration within the field, the NMC functions as a liaison between groups developing and applying metabolomics technology, actively promoting the transfer of knowledge and technology in the field of metabolomics through a network of committed partners. Together, the NMC team confronts the challenges of metabolomics research and develop the tools and strategies needed most by the Dutch and international research community. NMC works closely together with the Dutch Techcentre for Life Sciences, combining metabolomics with other life sciences technologies and bio-informatics to provide biological insights resulting from integrated life sciences approaches.

Netherlands Brain Bank (duplicate)

De Nederlandse Hersenbank Meibergdreef 47 1105 BA Amsterdam The NetherlandsNetherlands Brain Bank (NBB) is a non-profit organization that collects human brain tissue for neurological and psychiatric research.

Netherlands Cancer Institute (NKI) Digital Microscopy Facility

Plesmanlaan 121 1066 CX AmsterdamThe Digital microscopy facility is a broad, high level, light microscopy facility. It gives general microscopy support and provides access to advanced microscopes to all researchers in the Institute. At present the facility harbors nine microscopes, each with its own special functionality and together forming a complementary set of instruments. The facility has three operators (2.4 fte). Equipment and Applications The equipment consists of four confocals, four wide-field microscopes and a TIRF setup. All microscopes are of course suited to "manually" capture images of fixed or living samples. Except one, they are all fully motorized and well equipped for automated, un-attended image acquisition. Three confocals, two wide-field microscopes and the TIRF setup are equipped with home build 37 °C, 5% CO2 incubation chambers around the microscope, providing accurately controlled stable conditions, essential for demanding time-lapse studies. Four of these (two confocals, one wide-field system and the TIRF) are also equipped with a hardware autofocus system which can correct for focus drift in time. Unlike a software autofocus it does not require images to be taken and hence does not function at the expense of bleaching and photo-damage. All in all, the combination of the tightly controlled home build live-cell systems and the hardware autofocus greatly increases the chance of successful live-cell imaging, especially in case of long time-lapses at multiple positions.

Netherlands Cancer Institute (NKI) Digital Microscopy Facility

Plesmanlaan 121 Amsterdam, 1066 CX United StatesThe Digital microscopy facility is a broad, high level, light microscopy facility. It gives general microscopy support and provides access to advanced microscopes to all researchers in the Institute. At present the facility harbors nine microscopes, each with its own special functionality and together forming a complementary set of instruments. The facility has three operators (2.4 fte). Equipment and Applications The equipment consists of four confocals, four wide-field microscopes and a TIRF setup. All microscopes are of course suited to "manually" capture images of fixed or living samples. Except one, they are all fully motorized and well equipped for automated, un-attended image acquisition. Three confocals, two wide-field microscopes and the TIRF setup are equipped with home build 37 °C, 5% CO2 incubation chambers around the microscope, providing accurately controlled stable conditions, essential for demanding time-lapse studies. Four of these (two confocals, one wide-field system and the TIRF) are also equipped with a hardware autofocus system which can correct for focus drift in time. Unlike a software autofocus it does not require images to be taken and hence does not function at the expense of bleaching and photo-damage. All in all, the combination of the tightly controlled home build live-cell systems and the hardware autofocus greatly increases the chance of successful live-cell imaging, especially in case of long time-lapses at multiple positions.

NIZO Food Research BV

2 Kernhemseweg Ede, GE, 6718 ZB NetherlandsGood food needs good science. NIZO food research is a leading global center in proteins, bacteria, and processing. We are an independent company and one of the most advanced contract research centers in the world. We bring the latest food technologies to life in our own food grade processing plant. Our passion is to make better foods and to be an incubator of innovation. Our customers value their gains in sustainability, cost effectiveness and speed to market. - See more at: http://www.nizo.com/about-nizo/nizo-in-short/#sthash.Hnks5ozU.dpuf

Netherlands Cancer Institute (NKI) Peptide Facility

Plesmanlaan 121 1066 CX AmsterdamSince 1988 we have a facility in the Netherlands Cancer Institute to synthesize peptides for researchers in our institute outside. We use Fmoc-solid phase chemistry and in our facility we have three robots (a Prelude syntheziser and two Syro synthesizers). One of the Syro's can synthesize 48 peptides simultaneously. The other robot can synthesize in one run 3 times 96 peptides in small amounts (2 to 4 µmol) for screening purposes. The Prelude is used for larger amounts of peptides. Peptides are routinely synthesized in the range of 5-100 amino acids; in an amount of 2-200 µmol (larger amounts are possible). All peptides are analyzed by LCMS and if needed purified by RP-HPLC. For analytical purposes the peptide facility has a Waters liquid chromatography electro spray mass spectrometer at its disposal. More than 5,000 peptides are synthesized annually. Besides "straight forward" peptides we can also synthesize special peptides with unnatural amino acids, ubiquitin and its derivatives, biotinylated-, acetylated-, phosphorylated peptides, peptides with a side chain, custom dye labeled and UV cleavable peptides. All other options can be discussed. Please contact us if you want to know more.

Netherlands Cancer Institute (NKI) Peptide Facility

Plesmanlaan 121 Amsterdam, 1066 CX United StatesSince 1988 we have a facility in the Netherlands Cancer Institute to synthesize peptides for researchers in our institute outside. We use Fmoc-solid phase chemistry and in our facility we have three robots (a Prelude syntheziser and two Syro synthesizers). One of the Syro's can synthesize 48 peptides simultaneously. The other robot can synthesize in one run 3 times 96 peptides in small amounts (2 to 4 µmol) for screening purposes. The Prelude is used for larger amounts of peptides. Peptides are routinely synthesized in the range of 5-100 amino acids; in an amount of 2-200 µmol (larger amounts are possible). All peptides are analyzed by LCMS and if needed purified by RP-HPLC. For analytical purposes the peptide facility has a Waters liquid chromatography electro spray mass spectrometer at its disposal. More than 5,000 peptides are synthesized annually. Besides "straight forward" peptides we can also synthesize special peptides with unnatural amino acids, ubiquitin and its derivatives, biotinylated-, acetylated-, phosphorylated peptides, peptides with a side chain, custom dye labeled and UV cleavable peptides. All other options can be discussed. Please contact us if you want to know more.

Netherlands Cancer Institute (NKI) Biostatistics Center

Plesmanlaan 121 1066 CX AmsterdamBiostatistics is a key component of biomedical research and is essential for the interpretation of study results. Statistical techniques inform, among others, about the experimental design, treatment plan, evaluation of a new versus a standard treatment, and identify prognostic factors. The Biostatistics Center provides statistical expertise to researchers and doctors on diverse topics from all areas of observational and experimental biomedical cancer research. This involves developing and implementing statistical approaches to cover a wide range of topics including the design and analysis of epidemiologic studies and clinical trials, the identification of prognostic and predictive biomarkers, sample size calculations, risk prediction, as well as animal and in vitro experiments. In the recent past, the Biostatistics Center has been involved in, among others, prediction of hearing loss after cisplatin-based chemoradiation in patients with locally advanced head-and-neck cancer, biomarker-based treatment of breast cancer with adjuvant tamoxifen, comparison of platforms for array comparative genomic hybridization (aCGH) to identify breast cancers with a BRCA-like copy number profile, and dysphagia and trismus after concomitant chemo-Intensity-Modulated Radiation Therapy (chemo-IMRT) in advanced head and neck cancer. Moreover, the Biostatistics Center is closely involved with several international epidemiological studies on cancer incidence and exposure to chemicals and radiation, and it offers the annual Basic Medical Statistics Course.

Netherlands Cancer Institute (NKI) Biostatistics Center

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsBiostatistics is a key component of biomedical research and is essential for the interpretation of study results. Statistical techniques inform, among others, about the experimental design, treatment plan, evaluation of a new versus a standard treatment, and identify prognostic factors. The Biostatistics Center provides statistical expertise to researchers and doctors on diverse topics from all areas of observational and experimental biomedical cancer research. This involves developing and implementing statistical approaches to cover a wide range of topics including the design and analysis of epidemiologic studies and clinical trials, the identification of prognostic and predictive biomarkers, sample size calculations, risk prediction, as well as animal and in vitro experiments. In the recent past, the Biostatistics Center has been involved in, among others, prediction of hearing loss after cisplatin-based chemoradiation in patients with locally advanced head-and-neck cancer, biomarker-based treatment of breast cancer with adjuvant tamoxifen, comparison of platforms for array comparative genomic hybridization (aCGH) to identify breast cancers with a BRCA-like copy number profile, and dysphagia and trismus after concomitant chemo-Intensity-Modulated Radiation Therapy (chemo-IMRT) in advanced head and neck cancer. Moreover, the Biostatistics Center is closely involved with several international epidemiological studies on cancer incidence and exposure to chemicals and radiation, and it offers the annual Basic Medical Statistics Course.

Netherlands Cancer Institute (NKI) Molecular Pathology & Biobanking Core Facility

Plesmanlaan 121 1066 CX AmsterdamIn recent years, the need for controlling the 'secondary use' of human biospecimens for research purposes at the NKI became more apparent. To ensure human material is used properly and efficiently, especially in the case of scarce, valuable samples, a facility for use of NKI biobank materials was desired. Therefore, in 2011, the Core Facility Molecular Pathology & Biobanking (CFMPB) was founded. The CFMPB facilitates the use of NKI biobank materials for translational research. For all research projects, in which the use of NKI biobank materials is proposed, the Core Facility has to be contacted by the researcher. The CFMPB confirms that the Translational Research Board approves the usage of the material, does the sample handling (logistics), generates derivative biospecimen samples, and stores scientific results. Currently the facility's resources consist of a team of dedicated (lab) staff, dedicated lab space and equipment, and an in-house developed application and request tool.

Netherlands Cancer Institute (NKI) Molecular Pathology & Biobanking Core Facility

Plesmanlaan 121 Amsterdams, 1066 CX NetherlandsIn recent years, the need for controlling the 'secondary use' of human biospecimens for research purposes at the NKI became more apparent. To ensure human material is used properly and efficiently, especially in the case of scarce, valuable samples, a facility for use of NKI biobank materials was desired. Therefore, in 2011, the Core Facility Molecular Pathology & Biobanking (CFMPB) was founded. The CFMPB facilitates the use of NKI biobank materials for translational research. For all research projects, in which the use of NKI biobank materials is proposed, the Core Facility has to be contacted by the researcher. The CFMPB confirms that the Translational Research Board approves the usage of the material, does the sample handling (logistics), generates derivative biospecimen samples, and stores scientific results. Currently the facility's resources consist of a team of dedicated (lab) staff, dedicated lab space and equipment, and an in-house developed application and request tool.

Netherlands Cancer Institute (NKI) Carcinogen Laboratory

Plesmanlaan 121 1066 CX AmsterdamIn cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions. The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods. Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

Netherlands Cancer Institute (NKI) Carcinogen Laboratory

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsIn cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions. The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods. Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

NNZ

Aarhusweg 1 9723 JJ Groningen The NetherlandsNNZ is a multinational company owned and run by the family Boot since 1922. Its employees create packaging solutions for their clients in the fresh produce and industrial market. NNZ has the ambition to become a market driven company with the direct goal of creating packaging solutions for its partners through a worldwide network in both the agricultural-and industrial sector.

Netherlands Cancer Institute (NKI) Protein Facility

Plesmanlaan 121 1066 CX AmsterdamThe Protein facility of the Netherlands Cancer Institute started its activities in 2008 and shares lab space and equipment with the structural biology groups of Anastassis Perrakis and Titia Sixma at the Division of Biochemistry (B8). The facility offers an excellent infrastructure for biochemical, biophysical and structural biology experiments and contributes to a variety of research projects. Projects can be submitted to the facility (see contact details below) and will be discussed in terms of costs and feasibility before initiation of the project. Projects are classified as short-term (less than 3 days of work) and long-term (more than 3 days of work). For long-term projects hands-on assistance from the applicant is required. The activities of the facility can be subdivided into different categories. Construct design and cloning Protein production Protein purification Antibody production Biophysical characterization Crystallization screening Mass spectrometry

Netherlands Cancer Institute (NKI) Protein Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsThe Protein facility of the Netherlands Cancer Institute started its activities in 2008 and shares lab space and equipment with the structural biology groups of Anastassis Perrakis and Titia Sixma at the Division of Biochemistry (B8). The facility offers an excellent infrastructure for biochemical, biophysical and structural biology experiments and contributes to a variety of research projects. Projects can be submitted to the facility (see contact details below) and will be discussed in terms of costs and feasibility before initiation of the project. Projects are classified as short-term (less than 3 days of work) and long-term (more than 3 days of work). For long-term projects hands-on assistance from the applicant is required. The activities of the facility can be subdivided into different categories. Construct design and cloning Protein production Protein purification Antibody production Biophysical characterization Crystallization screening Mass spectrometry

Nutricia Research

Uppsalalaan 12 Utrecht Science Park 3584 CT Utrecht The NetherlandsPregnant and lactating women, infants, elderly and patients of all ages with special nutritional needs deserve nutritional support. Nutricia Research uses life science, food science, technology and the drive and expertise of over 600 employees to deliver nutritional products to those with special needs. Nutricia Research is the global R&D organisation behind Early Life Nutrition and Advanced Medical Nutrition, divisions of Danone, sharing its global mission to deliver health through food to as many people as possible. Our research and innovation areas have evolved, but we still begin with insights into nutrients and their role in optimal health, and build on that knowledge to tailor solutions for nutritional needs throughout the lifespan of our target populations.

Nutricia Research

Uppsalalaan 12 Utrecht Science Park Utrecht, 3584 CT NetherlandsPregnant and lactating women, infants, elderly and patients of all ages with special nutritional needs deserve nutritional support. Nutricia Research uses life science, food science, technology and the drive and expertise of over 600 employees to deliver nutritional products to those with special needs. Nutricia Research is the global R&D organisation behind Early Life Nutrition and Advanced Medical Nutrition, divisions of Danone, sharing its global mission to deliver health through food to as many people as possible. Our research and innovation areas have evolved, but we still begin with insights into nutrients and their role in optimal health, and build on that knowledge to tailor solutions for nutritional needs throughout the lifespan of our target populations.

Noldus Information Technology

Nieuwe Kanaal 5, 6709 PA WageningenNoldus Information Technology develops software and technology in the application of tracking animal behavior.

Nordic Immunology

Langendijk 25 Eindhoven, 5652 AX The NetherlandsNordic Immunology supplies basic immuno­logical reagents including antisera, antibodies, immuno­conju­gates, purified proteins, controls and calibrators.

Nutacon

Tuinderij 25, Postbus 94, 2450 AB Leimuiden The NetherlandsNutacon provides laboratory equipment and reagents.

NTRC

Pivot Park, RE1210, Molenstraat 110, 5342 CC Oss, The Netherlands

Netherlands Cancer Institute (NKI) Bioanalytical Laboratory for the Pharmacy

MC Slotervaart (2nd floor, B-wing) Louwesweg 6 1066 EC Amsterdam The NetherlandsThe strategic location of the GLP-certified laboratory close to the clinical research units of the Netherlands Cancer Institute facilitates the support of clinical studies with anticancer drugs with time-critical samples to be analysed (rapid turnaround times for dose escalation studies and therapeutic drug monitoring) and of mass balance studies preventing the shipment of radioactive samples. The co-located clinical research units enables innovative working collaboration with clinicians, efficient analysis and faster progress of clinical studies leading to a reduction in the costs. Know-how Our bioanalytical group is comprised of specialists with over 25 years of experience in bioanalysis, cooperation with sponsors and clinics. Our employees are specialised in the development of bioanalytical methods for complex anticancer drugs. We offer validated methods for the quantification of anticancer drugs that are ready for use, including ultra-sensitive methods down to lower limits of quantification of pg/mL in body fluids and methods for the quantification of anticancer drugs in other matrices (PBMCs, tumour tissues and DNA).

Netherlands Cancer Institute (NKI) Bioanalytical Laboratory for the Pharmacy

MC Slotervaart (2nd floor, B-wing) Louwesweg 6 Amsterdam, 1066 EC NetherlandsThe strategic location of the GLP-certified laboratory close to the clinical research units of the Netherlands Cancer Institute facilitates the support of clinical studies with anticancer drugs with time-critical samples to be analysed (rapid turnaround times for dose escalation studies and therapeutic drug monitoring) and of mass balance studies preventing the shipment of radioactive samples. The co-located clinical research units enables innovative working collaboration with clinicians, efficient analysis and faster progress of clinical studies leading to a reduction in the costs. Know-how Our bioanalytical group is comprised of specialists with over 25 years of experience in bioanalysis, cooperation with sponsors and clinics. Our employees are specialised in the development of bioanalytical methods for complex anticancer drugs. We offer validated methods for the quantification of anticancer drugs that are ready for use, including ultra-sensitive methods down to lower limits of quantification of pg/mL in body fluids and methods for the quantification of anticancer drugs in other matrices (PBMCs, tumour tissues and DNA).

Netherlands Cancer Institute (NKI) Sequencing Core Facility

Plesmanlaan 121 1066 CX AmsterdamSequencing Since 1999 the Netherlands Cancer Institute facilitates the Sequence Core where DNA sequencing and fragment analysis for research and diagnostic purposes is done. The 3730 DNA Analyzer with 48 capillaries and the 3500xL Genetic Analyzer with 24 capillaries (both Life technologies) are used for analyzing DNA samples. Both systems are based on polymer capillary electrophorese, with a maximum of 1,000 base read length. The reagent used for sequencing is BigDyeTerminator V3.1/V1.1. The BDT sequencing reaction has to be performed by users themselves. The Sequence Core Facility will purify and analyze the samples on one of the sequencers. Beside DNA sequencing it is also possible to analyze PCR-products with Fragment analysis. The length of PCR-products is determined using a fluorescent labeled primer. The Sequence Core Facility has a throughput of 110.000 samples a year. Within 24 hours, 90 percent of the samples is analyzed. The sequence data is available on a central server and will be stored after 6 months. Mass spectrometer The Mass-Array system by Agena Bioscience is a detection platform utilizing mass spectrometry to accurately measure PCR-derived amplicons. It combines the benefits of a multiplexed primer extension reaction with MALDI-TOF mass spectrometry to characterize genotypes. The system is ideal for panels from 10 to 400 single nucleotide polymorphisms. Workflow Primers for PCR and single base extension for the SNP of interest are designed with the assay software. DNA is provided by the user and will be processed by the Sequence Core Facility: Amplification of the region of interest with PCR Purification and single base extension Dispensing PCR-products on SpectroCHIP MALDI-TOF Mass spectrometer Analysis. This entire workflow can be completed in two days. Options - Custom made assay design Panel for the clinical DNA-diagnostics laboratory (70 hotspot mutations in AKT, BRAF, DDR2, EGFR, KRAS, MEK1, NRAS, PIK3CA) Your own panel for SNP/mutation detection - Pre-designed panels Oncocarta: This panel includes more than 230 somatic mutations across 19 oncogenes. Melacarta: This panel is designed specifically for metastatic melanoma profiling and offers 70 somatic mutations in 20 oncogenes. Lungcarta: This panel provides a highly sensitive panel for evaluating more than 250 somatic mutations in 26 genes for targeted profiling in non-small cell lung cancer (NSCLC). GyneCarta: This panel is designed for epithelial ovarian, cervical and endometrial cancer profiling. ColoCarta: This panel is designed for metastatic colorectal cancer.

Netherlands Cancer Institute (NKI) Sequencing Core Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsSequencing Since 1999 the Netherlands Cancer Institute facilitates the Sequence Core where DNA sequencing and fragment analysis for research and diagnostic purposes is done. The 3730 DNA Analyzer with 48 capillaries and the 3500xL Genetic Analyzer with 24 capillaries (both Life technologies) are used for analyzing DNA samples. Both systems are based on polymer capillary electrophorese, with a maximum of 1,000 base read length. The reagent used for sequencing is BigDyeTerminator V3.1/V1.1. The BDT sequencing reaction has to be performed by users themselves. The Sequence Core Facility will purify and analyze the samples on one of the sequencers. Beside DNA sequencing it is also possible to analyze PCR-products with Fragment analysis. The length of PCR-products is determined using a fluorescent labeled primer. The Sequence Core Facility has a throughput of 110.000 samples a year. Within 24 hours, 90 percent of the samples is analyzed. The sequence data is available on a central server and will be stored after 6 months. Mass spectrometer The Mass-Array system by Agena Bioscience is a detection platform utilizing mass spectrometry to accurately measure PCR-derived amplicons. It combines the benefits of a multiplexed primer extension reaction with MALDI-TOF mass spectrometry to characterize genotypes. The system is ideal for panels from 10 to 400 single nucleotide polymorphisms. Workflow Primers for PCR and single base extension for the SNP of interest are designed with the assay software. DNA is provided by the user and will be processed by the Sequence Core Facility: Amplification of the region of interest with PCR Purification and single base extension Dispensing PCR-products on SpectroCHIP MALDI-TOF Mass spectrometer Analysis. This entire workflow can be completed in two days. Options - Custom made assay design Panel for the clinical DNA-diagnostics laboratory (70 hotspot mutations in AKT, BRAF, DDR2, EGFR, KRAS, MEK1, NRAS, PIK3CA) Your own panel for SNP/mutation detection - Pre-designed panels Oncocarta: This panel includes more than 230 somatic mutations across 19 oncogenes. Melacarta: This panel is designed specifically for metastatic melanoma profiling and offers 70 somatic mutations in 20 oncogenes. Lungcarta: This panel provides a highly sensitive panel for evaluating more than 250 somatic mutations in 26 genes for targeted profiling in non-small cell lung cancer (NSCLC). GyneCarta: This panel is designed for epithelial ovarian, cervical and endometrial cancer profiling. ColoCarta: This panel is designed for metastatic colorectal cancer.

Netherlands Cancer Institute (NKI) Flow Cytometry Facility

Plesmanlaan 121 1066 CX AmsterdamFlow cytometry is a laser based, biophysical technology used for cell counting, sorting, and biomarker detection. Cells are suspended in a stream of fluid and passed by an electronic detection apparatus. It allows simultaneous multi-parametric analysis of the physical and/or chemical characteristics of up to thousands of cells per second. Based on the characteristics cells can also be sorted with high precision allowing subsequent experiments with well-defined cell populations. The Netherlands Cancer Institute has a Flow cytometry facility with several analyzers and two sorters. The two operators maintain the equipment, give advice and training and perform sorting experiments. Activities and services Researchers are offered hands-on training to learn the principles of flow cytometry and to operate the analysers themselves. The analysers are available to trained users 24/7. The ability to measure multiple parameters on individual cells is the most powerful aspect of flow cytometry. This allows flow cytometry to be used for a wide range of applications. Among the most common applications at the Netherlands Cancer Insitute are immune phenotyping with up to 18 colours, apoptosis assays using annexin V, cell cycle analysis, and analysis of cells expressing one or more fluorescent proteins. Lots of other applications are used and new applications are set up by the operators together with the researchers. Through close cooperation of fluidics, laser technology and electronics it is possible to separate specific cells out of a cell suspension using the sorters at the facility. We are capable of sorting up to 16 colours into 6 fractions or into multiwall plates. We can also sorting into microwell slides. The development of these cells was followed under a confocal microscope at the digital microscopy facility. Equipment There are currently six flow cytometry analysers and two high speed cell sorters in the facility. BD LSRII with 5 lasers (488 nm, 355 nm, 405 nm, 561 nm and 635 nm) and 18 fluorescence detectors BD Fortessa with 4 lasers (488 nm, 405 nm, 561 nm and 635 nm) and 15 fluorescence detectors equipped with a HTS-loader for sampling out of a multiwell plate Two Becton Dickinson FACSCalibur analysers, one of which is capable of sampling out of a multiwell plate, with 2 lasers (488 nm, 635nm) and 4 fluorescence detectors Beckman Coulter Cyan, 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectors BD FacsArray, 2 lasers (532 nm and 635) and 4 fluorescence detectors capable of sampling out of a 96-wells plate BD FacsAria Sorter with 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectors for high speed 4-way bulk sorting and single cell deposition sorting. Beckman Coulter Moflo Astrios 4 lasers (488nm, 405 nm, 561 nm

Netherlands Cancer Institute (NKI) Flow Cytometry Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsFlow cytometry is a laser based, biophysical technology used for cell counting, sorting, and biomarker detection. Cells are suspended in a stream of fluid and passed by an electronic detection apparatus. It allows simultaneous multi-parametric analysis of the physical and/or chemical characteristics of up to thousands of cells per second. Based on the characteristics cells can also be sorted with high precision allowing subsequent experiments with well-defined cell populations. The Netherlands Cancer Institute has a Flow cytometry facility with several analyzers and two sorters. The two operators maintain the equipment, give advice and training and perform sorting experiments. Activities and services Researchers are offered hands-on training to learn the principles of flow cytometry and to operate the analysers themselves. The analysers are available to trained users 24/7. The ability to measure multiple parameters on individual cells is the most powerful aspect of flow cytometry. This allows flow cytometry to be used for a wide range of applications. Among the most common applications at the Netherlands Cancer Insitute are immune phenotyping with up to 18 colours, apoptosis assays using annexin V, cell cycle analysis, and analysis of cells expressing one or more fluorescent proteins. Lots of other applications are used and new applications are set up by the operators together with the researchers. Through close cooperation of fluidics, laser technology and electronics it is possible to separate specific cells out of a cell suspension using the sorters at the facility. We are capable of sorting up to 16 colours into 6 fractions or into multiwall plates. We can also sorting into microwell slides. The development of these cells was followed under a confocal microscope at the digital microscopy facility. Equipment There are currently six flow cytometry analysers and two high speed cell sorters in the facility. BD LSRII with 5 lasers (488 nm, 355 nm, 405 nm, 561 nm and 635 nm) and 18 fluorescence detectors BD Fortessa with 4 lasers (488 nm, 405 nm, 561 nm and 635 nm) and 15 fluorescence detectors equipped with a HTS-loader for sampling out of a multiwell plate Two Becton Dickinson FACSCalibur analysers, one of which is capable of sampling out of a multiwell plate, with 2 lasers (488 nm, 635nm) and 4 fluorescence detectors Beckman Coulter Cyan, 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectors BD FacsArray, 2 lasers (532 nm and 635) and 4 fluorescence detectors capable of sampling out of a 96-wells plate BD FacsAria Sorter with 3 lasers (488nm, 405 nm,633 nm) and 9 fluorescence detectors for high speed 4-way bulk sorting and single cell deposition sorting. Beckman Coulter Moflo Astrios 4 lasers (488nm, 405 nm, 561 nm

Netherlands Cancer Institute (NKI) Genomics Core Facility

Plesmanlaan 121 1066 CX AmsterdamNext generation sequencing, also sometimes called deep sequencing, is our core business. We have a team of over 10 people, both wet lab technicians and bioinformaticians, to support the research and the clinical application of this technology using multiple Illumina HiSeq2000 and MiSeq machines. The applications for this technology are widespread, still growing and are common practice in the institute. Every aspect of the deep sequencing process is supported by the GCF that, as a facility, has a large body of experience and knowledge. The facility has been using Illumina technology from the early onset of the NGS development in 2009 and therefore we are now in a position to support the users with clear advice as to how the experiment should be designed to increase the success rate of the experiment. We are open to suggestions and are flexible in the way users want to have their samples analyzed with regard to sequence depth and numbers of libraries that are pooled in multiplexed experiments. The facility is set up according to a fee-for-service model where the material and chemistry cost prize is the main factor that determines the fee, this makes our support very affordable compared to external service providers. Facility users can provide cells or tissues as starting material but we also work with purified RNA or DNA as well as ready to sequence DNA libraries. All the necessary equipment for the preparation of sequence libraries and the associated quality control steps are in house. For some applications, like RNAseq, the demand is so high that we run the sample preparation in 96-wells format using PE SciClone robotic pipetting systems. The bulk of the experiments are performed using validated Illumina protocols and kits, but extensive experience has made it possible to either adapt, or develop new protocols for creating sequencing libraries. This is often done in close collaboration with the end user. New developments are closely followed and can be implemented relatively quickly. The data generated by the sequencing machines is stored on a central server system and analyzed by the facilities bioinformaticians. All data can also be made directly available to the user in the desired format. We have pipelines for demultiplexing the data, the alignment of the reads to genomes of choice and experiment specific downstream analysis. We can provide the results in tabular or graphical formats or prepare them for visualization in genome viewers like IGV (http://www.broad.mit.edu/igv/). We also host licenses for third party software solutions for analysis like Ingenuity and Nexus. Equipment HiSeq2000 (2x), MiSeq, cBot, Perkin Elmer NGSx Sciclone Workstation, Covaris, Agilent BioAnalyzer, Perkin Elmer-Gx system, Biomek Fx, Agilent Scanner, Illumina Beadarray Reader, Tecan Hybstations, Nimblegen Hybstation, MicroGrid Printrobot.

Netherlands Cancer Institute (NKI) Genomics Core Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsNext generation sequencing, also sometimes called deep sequencing, is our core business. We have a team of over 10 people, both wet lab technicians and bioinformaticians, to support the research and the clinical application of this technology using multiple Illumina HiSeq2000 and MiSeq machines. The applications for this technology are widespread, still growing and are common practice in the institute. Every aspect of the deep sequencing process is supported by the GCF that, as a facility, has a large body of experience and knowledge. The facility has been using Illumina technology from the early onset of the NGS development in 2009 and therefore we are now in a position to support the users with clear advice as to how the experiment should be designed to increase the success rate of the experiment. We are open to suggestions and are flexible in the way users want to have their samples analyzed with regard to sequence depth and numbers of libraries that are pooled in multiplexed experiments. The facility is set up according to a fee-for-service model where the material and chemistry cost prize is the main factor that determines the fee, this makes our support very affordable compared to external service providers. Facility users can provide cells or tissues as starting material but we also work with purified RNA or DNA as well as ready to sequence DNA libraries. All the necessary equipment for the preparation of sequence libraries and the associated quality control steps are in house. For some applications, like RNAseq, the demand is so high that we run the sample preparation in 96-wells format using PE SciClone robotic pipetting systems. The bulk of the experiments are performed using validated Illumina protocols and kits, but extensive experience has made it possible to either adapt, or develop new protocols for creating sequencing libraries. This is often done in close collaboration with the end user. New developments are closely followed and can be implemented relatively quickly. The data generated by the sequencing machines is stored on a central server system and analyzed by the facilities bioinformaticians. All data can also be made directly available to the user in the desired format. We have pipelines for demultiplexing the data, the alignment of the reads to genomes of choice and experiment specific downstream analysis. We can provide the results in tabular or graphical formats or prepare them for visualization in genome viewers like IGV (http://www.broad.mit.edu/igv/). We also host licenses for third party software solutions for analysis like Ingenuity and Nexus. Equipment HiSeq2000 (2x), MiSeq, cBot, Perkin Elmer NGSx Sciclone Workstation, Covaris, Agilent BioAnalyzer, Perkin Elmer-Gx system, Biomek Fx, Agilent Scanner, Illumina Beadarray Reader, Tecan Hybstations, Nimblegen Hybstation, MicroGrid Printrobot.

Netherlands Cancer Institute (NKI) Mouse Clinic - Intervention Unit

Plesmanlaan 121 1066 CX AmsterdamIn recent years the NKI has made major investments to establish and further develop a dedicated Mouse Cancer Clinic for therapeutic intervention studies using mouse models of human cancer. Various novel approaches to treat cancer have already been tested in the Mouse Cancer Clinic. The design of the experiments is guided by both novel insights from basic research and clinical demands. Over the past years the maximum tolerable dose and anti-cancer efficacy of various anti-cancer agents that are frequently used in the clinic such as taxanes, topoisomerase I or II inhibitors, platinum drugs, or DNA alkylating agents have been benchmarked for several mouse cancer models. In close collaboration with pharmaceutical companies and academic partners several novel anti-cancer agents that are eligible for clinical trials have been or are being tested in our advanced mouse models. This includes targeted inhibitors of pathways involved in tumor cell proliferation, cell death or DNA repair. Moreover, new generation compounds that represent optimized versions of already existing drugs are investigated. The main reason why patients with disseminated cancer die is resistance or tolerance to systemic treatment. Therefore, one focus of the Intervention Unit is to understand mechanisms of drug resistance and to identity therapeutic approaches that circumvent or reverse resistance. Another central handicap in clinical oncology is the lack of predictive markers, since many patients only suffer from the side effects of an unsuccessful treatment. Hence, a major goal of the Intervention Unit is to use mouse models to identify biomarkers that predict the response of tumors before treatment is started. In addition to systemic therapies, we are also investigating locoregional applications of drugs, surgery or radiation. The identification and treatment of tumors is greatly facilitated by dedicated systems for state-of-the-art imaging and image-guided radiation therapy of small animals. Preclinical imaging systems are essential for accurate measurement of tumor growth, metastasis formation and therapy response in mouse models of human cancer. For this purpose, a dedicated Imaging Unit has been realized within the Mouse Clinic. The goal of this unit is to carry out attractive research that addresses relevant questions encountered by clinical imaging of cancer patients. This Unit includes a NanoSPECT/CT system (Bioscan) for combined single-photon emission computed tomography (SPECT) and computed tomography (CT) imaging, as well as IVIS systems (Caliper Corp.) for bioluminescence and fluorescence imaging. These systems are frequently used to measure drug responses of mouse models of breast, lung or brain cancer and to monitor metastasis formation. Due to the generous support of the Netherlands Organisation for Scientific Research, we will upgrade our present equipment in the coming months, and invest also in magnetic resonance imaging (MRI) and positron-emission tomography (PET). In sum, the Mouse Cancer Clinic aims to provide a controlled environment with state-of-the-art infrastructure for testing of therapeutic approaches that may subsequently be applied to cancer patients.

Netherlands Cancer Institute (NKI) Mouse Clinic - Intervention Unit

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsIn recent years the NKI has made major investments to establish and further develop a dedicated Mouse Cancer Clinic for therapeutic intervention studies using mouse models of human cancer. Various novel approaches to treat cancer have already been tested in the Mouse Cancer Clinic. The design of the experiments is guided by both novel insights from basic research and clinical demands. Over the past years the maximum tolerable dose and anti-cancer efficacy of various anti-cancer agents that are frequently used in the clinic such as taxanes, topoisomerase I or II inhibitors, platinum drugs, or DNA alkylating agents have been benchmarked for several mouse cancer models. In close collaboration with pharmaceutical companies and academic partners several novel anti-cancer agents that are eligible for clinical trials have been or are being tested in our advanced mouse models. This includes targeted inhibitors of pathways involved in tumor cell proliferation, cell death or DNA repair. Moreover, new generation compounds that represent optimized versions of already existing drugs are investigated. The main reason why patients with disseminated cancer die is resistance or tolerance to systemic treatment. Therefore, one focus of the Intervention Unit is to understand mechanisms of drug resistance and to identity therapeutic approaches that circumvent or reverse resistance. Another central handicap in clinical oncology is the lack of predictive markers, since many patients only suffer from the side effects of an unsuccessful treatment. Hence, a major goal of the Intervention Unit is to use mouse models to identify biomarkers that predict the response of tumors before treatment is started. In addition to systemic therapies, we are also investigating locoregional applications of drugs, surgery or radiation. The identification and treatment of tumors is greatly facilitated by dedicated systems for state-of-the-art imaging and image-guided radiation therapy of small animals. Preclinical imaging systems are essential for accurate measurement of tumor growth, metastasis formation and therapy response in mouse models of human cancer. For this purpose, a dedicated Imaging Unit has been realized within the Mouse Clinic. The goal of this unit is to carry out attractive research that addresses relevant questions encountered by clinical imaging of cancer patients. This Unit includes a NanoSPECT/CT system (Bioscan) for combined single-photon emission computed tomography (SPECT) and computed tomography (CT) imaging, as well as IVIS systems (Caliper Corp.) for bioluminescence and fluorescence imaging. These systems are frequently used to measure drug responses of mouse models of breast, lung or brain cancer and to monitor metastasis formation. Due to the generous support of the Netherlands Organisation for Scientific Research, we will upgrade our present equipment in the coming months, and invest also in magnetic resonance imaging (MRI) and positron-emission tomography (PET). In sum, the Mouse Cancer Clinic aims to provide a controlled environment with state-of-the-art infrastructure for testing of therapeutic approaches that may subsequently be applied to cancer patients.

New Brunswick Scientific

Kerkenbos 1101, 6546 BC NijmegenNew Brunswick Scientific offers optimization, cell expertise, computer-controlled strategies, and media formulation.

Ncardia

Galileiweg 8 Leiden, BD, 2333 NetherlandsThe business objective of Ncardia lies in the area of pre-clinical biotechnology, specifically in the development and production of stem cell-derived cell types (e.g. cardiac & neuronal cells) and cell-based assays that enable drug development. These innovative and proprietary cell types and assays accelerate and improve drug candidate selection, lower costs and thus increase overall drug development efficiency.

Ncardia

Galileiweg 8 Leiden, BD2333 NetherlandsThe business objective of Ncardia lies in the area of pre-clinical biotechnology, specifically in the development and production of stem cell-derived cell types (e.g. cardiac & neuronal cells) and cell-based assays that enable drug development. These innovative and proprietary cell types and assays accelerate and improve drug candidate selection, lower costs and thus increase overall drug development efficiency.

Netherlands Cancer Institute (NKI) Electron Microscope Facility

Plesmanlaan 121 1066 CX AmsterdamThe Electron Microscope (EM) facility enables researchers at the Netherlands Cancer Institute to look at cellular structures and protein complexes at high magnification. The dedicated EM operator performs the sample preparation and acquisition of data. The EM-lab is located at the NKI, location B6. Here all the preparation of the samples and sectioning with the ultramicrotomes is done. Since September of 2015 the facility makes use of the electron microscopes at the AMC.

Netherlands Cancer Institute (NKI) Electron Microscope Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsThe Electron Microscope (EM) facility enables researchers at the Netherlands Cancer Institute to look at cellular structures and protein complexes at high magnification. The dedicated EM operator performs the sample preparation and acquisition of data. The EM-lab is located at the NKI, location B6. Here all the preparation of the samples and sectioning with the ultramicrotomes is done. Since September of 2015 the facility makes use of the electron microscopes at the AMC.

Netherlands Cancer Institute (NKI) Proteomics Facility

Plesmanlaan 121 1066 CX AmsterdamThe Facility provides assessment of protein composition of a variety of samples. Preferably, researchers first discuss with us the project(s) they have coming up, in order to design the optimal experimental setup allowing successful analysis by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS). For quantitative proteomics experiments, stable isotope labeling at the peptide or protein level can be considered. After performing the experiment, researchers hand in their samples, which we process further for LC-MS/MS. Sample processing involves protein extraction, reduction, alkylation, proteolytic digestion, (optional) multiplex stable isotope labeling and desalting. Finally, peptides are separated by nanoflow reversed-phase liquid chromatography, and analyzed by tandem mass spectrometry. After mass spectrometry analysis, MS/MS spectra are processed with dedicated software to yield protein identification (and quantification, if applicable). Results are exported as Excel workbook and shared with the researcher. Limited bioinformatics analysis can be discussed for further data interpretation. What we take: cell pellets or cell lysates; protein fractions; immunoaffinity beads or eluates from immunoprecipitations; SDS-PAGE gels*. Other sample types? Come and discuss the possibilities! *We prefer to run SDS-PAGE gels ourselves and cut gel bands here at the Facility, so if you're interested in analyzing specific bands, we'd like you to provide protein samples rather than a gel. What we offer: Quantitative & Qualitative (full) proteome analysis; Phosphoproteome analysis; Ubiquitinated proteome analysis Other requests? Come and discuss the possibilities! Targeted protein quantitation (parallel reaction monitoring). Internal projects are on a collaborative basis and free of charge, fitting within the capacity and scope of the facility. However, certain expensive reagents (kits, antibodies etc.) may have to be purchased by the researcher.

Netherlands Cancer Institute (NKI) Proteomics Facility

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsThe Facility provides assessment of protein composition of a variety of samples. Preferably, researchers first discuss with us the project(s) they have coming up, in order to design the optimal experimental setup allowing successful analysis by liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS). For quantitative proteomics experiments, stable isotope labeling at the peptide or protein level can be considered. After performing the experiment, researchers hand in their samples, which we process further for LC-MS/MS. Sample processing involves protein extraction, reduction, alkylation, proteolytic digestion, (optional) multiplex stable isotope labeling and desalting. Finally, peptides are separated by nanoflow reversed-phase liquid chromatography, and analyzed by tandem mass spectrometry. After mass spectrometry analysis, MS/MS spectra are processed with dedicated software to yield protein identification (and quantification, if applicable). Results are exported as Excel workbook and shared with the researcher. Limited bioinformatics analysis can be discussed for further data interpretation. What we take: cell pellets or cell lysates; protein fractions; immunoaffinity beads or eluates from immunoprecipitations; SDS-PAGE gels*. Other sample types? Come and discuss the possibilities! *We prefer to run SDS-PAGE gels ourselves and cut gel bands here at the Facility, so if you're interested in analyzing specific bands, we'd like you to provide protein samples rather than a gel. What we offer: Quantitative & Qualitative (full) proteome analysis; Phosphoproteome analysis; Ubiquitinated proteome analysis Other requests? Come and discuss the possibilities! Targeted protein quantitation (parallel reaction monitoring). Internal projects are on a collaborative basis and free of charge, fitting within the capacity and scope of the facility. However, certain expensive reagents (kits, antibodies etc.) may have to be purchased by the researcher.

Netherlands Cancer Institute (NKI) Mouse Clinic - Imaging Unit

Plesmanlaan 121 1066 CX AmsterdamMedical Imaging using different techniques. Instruments: Bruker Biospec 7T MRI Albira PET/CT MILabs USPECT/CT Bruker ICON 1T MRI PerkinElmer IVIS Spectrum

Netherlands Cancer Institute (NKI) Mouse Clinic - Imaging Unit

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsMedical Imaging using different techniques. Instruments: Bruker Biospec 7T MRI Albira PET/CT MILabs USPECT/CT Bruker ICON 1T MRI PerkinElmer IVIS Spectrum

Netherlands Cancer Institute (NKI) Radionuclides Centre

Plesmanlaan 121 1066 CX AmsterdamIn cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions. The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods. Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

Netherlands Cancer Institute (NKI) Radionuclides Centre

Plesmanlaan 121 Amsterdam, 1066 CX NetherlandsIn cancer research we use a lot of dangerous compounds. The carcinogen lab is a research facility where carcinogenic, mutagenic and reprotoxic compounds can be stored and were these compounds can be handled under special safety conditions. The carcinogen laboratory is mainly used to prepare solutions using chemicals in a powder form. The chemicals can be weighted in a fume hood, dissolved and then taken out of the carcinogen laboratory for use in experiments. The lab is under-pressured, has a higher than normal ventilation fold and is equipped with two safety hoods. Researchers can get instructions on how to work with carcinogens and about safety aspects. The instructions and the information is given by one of the supervisors of this facility. They also make sure everything is working properly and is kept clean and tidy.

Orbiscope Powered by Polyscope

Prins de Lignestraat 28 --- Geleen, ---, 6161 CZ NetherlandsOrbiscope® Powered by Polyscope® Taking SMA® one step further Our goal is to inspire and assist you to push your application’s boundaries to the next level, utilizing styrene-maleic anhydride (SMA) copolymers and/or their derivatives. Besides offering commercial and experimental SMA-based copolymers for your research needs, we also aim to support your development efforts. SMA® Poly(styrene-maleic anhydride) copolymers (SMA®) are a highly versatile copolymer class, containing both hydrophobic moieties (styrene) and reactive, functionalizable moieties (anhydride). The properties of the base polymer are determined by the ratio of styrene to maleic anhydride and by the molecular weight. SMA® native resins are amorphous thermoplastic polymers that are very transparent and exhibit high heat resistance and dimensional stability. SMALP® Styrene-maleic anhydride (SMA) copolymers are used as a detergent-free approach for membrane protein solubilization, isolation and cell membranes and subsequent characterization in downstream methods. SMA copolymers have proven their value in the solubilization, purification, and characterization of a variety of membrane proteins, as described in over 200 scientific articles including comprehensive review articles. The usage of SMA copolymers for these applications is protected by patents for which Polyscope has liscences.

OYC Europe

Groothandelsgebouw Conradstraat 18 Rotterdam, 3013 AP The NetherlandsOYC Europe, a wholly owned subsidiary of Oriental Yeast Co., Ltd. (OYC Japan), supplies biochemical products such as enzymes, coenzymes (co-factors), monoclonal/polyclonal antibodies, recombinant proteins and superior quality liquid stable chemistry reagents.

OYC Europe

Rotterdam, ZH NetherlandsOYC Europe, a wholly owned subsidiary of Oriental Yeast Co., Ltd. (OYC Japan), supplies biochemical products such as enzymes, coenzymes (co-factors), monoclonal/polyclonal antibodies, recombinant proteins and superior quality liquid stable chemistry reagents.

OPEN Health

Marten Meesweg 107 Rotterdam, ZH, 3068AV NetherlandsOPEN Health brings together deep scientific knowledge, global understanding, and broad specialist expertise to support our clients in improving health outcomes and patient wellbeing. Our journey began with a vision to improve the lives of patients worldwide. This vision has become a reality with the integration of experts from Pharmerit International and Peloton Advantage to create a new unique entity equipped to be a global leader in HEOR and medical communications. We are united as one flexible organization, harnessing the power of the collective to solve complex challenges. Being built from cohesive partnerships across a range of specialist sectors gives us the ability to approach opportunities from fresh perspectives, creating solutions and innovations for market access and medical communications that are informed by the experience and knowledge of the many. Our global team of experts — many with PhD or PharmD degrees — work strategically alongside our client partners in Medical Affairs, Health Economics and Outcomes Research (HEOR), Market Access, and Commercial teams across a wide range of therapy areas. OPEN Health – Established as many. United as one.

OctoPlus

Zernikedreef 12 2333 CL Leiden The NetherlandsOctoPlus provides formulation of active ingredients for all common forms of administration.

OctoPlus

Leiden, ZH NetherlandsOctoPlus provides formulation of active ingredients for all common forms of administration.

Occams

Malandolaan 10 Amstelveen, NH, 1187 HE NetherlandsOccams provides high-quality strategic services to clients in the pharmaceutical industry. Using mathematical modelling and simulation, relationships between administered drug amounts, resulting drug concentrations and their pharmacodynamic effects can be described and investigated in patient populations. We derive our name from the heuristic principle known as Occam’s razor, attributed to the Franciscan friar William of Ockham (1287-1347): when multiple explanations are equally capable of describing the outcome, the least complex solution is preferred. This strategy produces stable and robust models that are easier to communicate and to apply to the questions that matter.

Ocimum Biosolutions

Lagedijk, Noord 18Ocimum offers gene and microRNA expression profiling, SNP genotyping, copy number analysis, DMET, gene sequencing, biomarker discovery and molecular diagnostic services and software development.

Onno Jongerius Consult

26 Begijnenhof Molenhoek, LI, 6584 CW NetherlandsOnno Jongerius Consult BV ( “Jongerius Consult”) is specialised in chemicals legislation; focussing on how to organise Chemical Regulatory Compliance (CRC) efficiently and effectively within a company in its supply chain. Jongerius Consult offers strategic and practical support of high quality to the various stakeholders working to an efficient and successful implementation of the chemicals management processes to deal with the European chemicals legislation within a company, industry sector or supply chain. The core is currently formed by the REACH Regulation (EC) 1907/2006 and the CLP regulation (EC) 1272/2008. In parallel, we offer Chemical Regulatory Compliance (CRC) support to frontrunner companies / industry sectors that have to deal with new chemical regulatory requirements or are confronted with conflicting regulatory requirements from different chemicals legislations in the European Union. We are appreciated for our fast understanding of the critical points and ‘out of the box’ thinking coming to practical solutions in connection to the existing chemicals management processes and information systems.

Proeftuin Zwaagdijk

Tolweg 13 1681 ND Zwaagdijk-Oost

Particle Sizing Systems

Waterman 182Particle Sizing Systems offers particle size analyzers, potential analyzers, classification and homogenization, and stability analyzers.

PamGene

Wolvenhoek 10 'S-HERTOGENBOSCH, 5211 HH NetherlandsBuilding on 15 years of experience, PamGene has developed a unique technology making real-time measurement and understanding of kinase activity possible. Our multiplex, functional kinase activity profiling technology reveals the bigger picture of cellular signaling and provides mechanistic insights needed to fully understand diseases and cell alterations. We offer Contract Research Services tailored to your needs and research questions in the areas: Kinase inhibitor selectivity profiling Pathway elucidation Drug-target interaction Target discovery and identification Biochemical identification Biomarker discovery and identification The benefits our technology brings to your research • Wide coverage – 340 Phosphosites are used to cover the majority of the Kinome. • Kinase activity-based – Direct inhibitor effects on kinases can be measured. • Sensitive – Only small amounts of protein input (0.5 to 5 μg per array) are required, thus making the assay more sensitive than alternative approaches. • No specific antibodies – The quality of the data is not dependent on the specificity of phospho-antibodies since specificity is derived from the 340 phosphosites. • Full-length kinases – We can measure kinase activity of full-length proteins from lysates of several cell lines and tissues, not offered by other recombinant-based kinase activity assays. PamChip Kinome coverage Based on current online knowledge, we compiled a com-prehensive, integrated database of potential kinases that are linked to the peptides on the PamChips. This corresponds to ~350 unique kinases in literature, covering the majority of the Kinome.

PamGene

10 Wolvenhoek 's-Hertogenbosch, NB, 5211 HH NetherlandsBuilding on 15 years of experience, PamGene has developed a unique technology making real-time measurement and understanding of kinase activity possible. Our multiplex, functional kinase activity profiling technology reveals the bigger picture of cellular signaling and provides mechanistic insights needed to fully understand diseases and cell alterations. We offer Contract Research Services tailored to your needs and research questions in the areas: Kinase inhibitor selectivity profiling Pathway elucidation Drug-target interaction Target discovery and identification Biochemical identification Biomarker discovery and identification The benefits our technology brings to your research • Wide coverage – 340 Phosphosites are used to cover the majority of the Kinome. • Kinase activity-based – Direct inhibitor effects on kinases can be measured. • Sensitive – Only small amounts of protein input (0.5 to 5 μg per array) are required, thus making the assay more sensitive than alternative approaches. • No specific antibodies – The quality of the data is not dependent on the specificity of phospho-antibodies since specificity is derived from the 340 phosphosites. • Full-length kinases – We can measure kinase activity of full-length proteins from lysates of several cell lines and tissues, not offered by other recombinant-based kinase activity assays. PamChip Kinome coverage Based on current online knowledge, we compiled a com-prehensive, integrated database of potential kinases that are linked to the peptides on the PamChips. This corresponds to ~350 unique kinases in literature, covering the majority of the Kinome.

Pepscan Presto

Zuidersluisweg 2 Lelystad , 8243 RC NetherlandsPepscan is the all-in-one peptide service provider, building on 25 years of experience in advancing and applying peptide expertise to facilitate clients in the development and (GMP) production of peptides. - Peptide discovery - Unique service for de novo discovery of the best peptide binders for your target protein of interest - Peptide lead optimization - Increasing peptide drug potency and improving pharmacokinetic properties through lead optimization of linear and CLIPS-constrained peptides - Clinical and R&D peptide synthesis - Combining smart peptide science and flexible manufacturing capabilities conform GMP - Personalized peptides for neoantigen vaccines - Robust timelines, extensive knowledge and experience and redundant set-up in our all-in-one facility make us the reliable personalized peptide supplier - Epitope mapping - Defining linear, conformational and discontinuous epitopes: accurate and cost-effective At its end-to-end facility in Lelystad, the Netherlands, Pepscan offers a range of patented technologies, phage display capabilities, a lead-optimization array platform, and production facilities for R&D- to GMP-grade peptides, including libraries and neoantigen vaccines. Among its patents is the CLIPS technology, which locks peptides into active conformations. With its epitope mapping service platform, Pepscan also supports biotech companies in developing their antibody pipelines. The underlying protein mimicry platform delivers binding insights, even in cases where other technologies, such as linear, fall short. For more information please visit our website: www.pepscan.com

Pepscope B.V.

8 Padualaan Utrecht, UT, 3584 CH NetherlandsPEPSCOPE's core product is QuantaKinome(tm), a groundbreaking, targeted MS-based technology for profiling the network activity of endogenous protein kinases in human tissues, patient samples and in vitro samples. Pepscope is a Dutch biotech company providing tailored, in-depth kinome and protein profiling. We use a combination of novel technologies to measure protein activities, including protein kinases. Protein kinases are key cell regulators, associated with multiple diseases. Using cutting-edge Mass Spectrometry technologies, we generate unique information about kinase activities in cells and tissues. With these insights, we aim to accelerate drug development and enable patient individualized therapy selection. In addition, we develop diagnostic tools to improve cancer treatment and early detection of breast cancer, glioblastoma, colon cancer, and others. Our solutions comprise: - QuantaKinome(tm) - Targeted, multiplexed kinase activity profiling assays - Phosphoproteomics - allowing simultaneous quantification of thousands of phosphopeptides and phosphopeptides in a single experiment on state-of-the-art mass spec equipment. Through our collaboration with the Utrecht University - Group of Prof. M. Altelaar and A. Heck, and Erasmus Medical Center in Rotterdam – Departments of Theo Luider (Neurology), Sieger Leenstra (Neurosurgery), Maikel Peppelenbosch (MDL) – as well as with industry partners we continuously advance our capabilities and competencies in mass spectrometry-based proteomics and kinome profiling technologies. Therefore, we have the ability to deliver unrivaled comprehensiveness and data quality for the analysis of cells and tissue samples.

Pharmaceutical Product Development (PPD)

Bornweg 12c 6721 AH Bennekom The NetherlandsPPD offers central lab services, bioanalytical services, biomarker discovery services, assay development services, cGMP analytical services, CMC consulting, and pharmacology services.

PickCell Laboratories

Kruislaan 406PickCell Laboratories provide peptide, antibody, and hybridoma services.

PRISNA

P.O.Box 506 Oostvoorne, 3233 ZK The NetherlandsPRISNA (Product Isolation from Nature), a consortium of several independent Dutch companies and the department of Pharmacognosy at the Leiden University, offers natural product libraries, LC-MS analysis, NMR analysis, supercritical technologies, and Centrifugal Partition Chromatography.

Parexel

Herman Heijermansweg 20Parexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

PHARMO Institute

Van Deventerlaan 30-40 3528 AE Utrecht The NetherlandsFounded in 1999, PHARMO is an independent research organisation dedicated to the study of epidemiology, drug utilisation, drug safety, health outcomes, and utilisation of healthcare resources. PHARMO developed and maintains a large and high quality Database Network and works closely with (inter)national medical universities and European databases. Through its studies with longitudinal and real world patient data, the PHARMO Institute contributes to risk management and outcomes research and provides solutions for decision-makers in market access, health economics and health outcomes domains. Our mission is to achieve greater insights into the real world of healthcare, through the collection and expert analysis of patient-centric information.

Plich Advisory

Strawinskylaan 3051 Floor 4 Amsterdam, Select, 1077ZX Netherlands

Partners 4 Access

Boslaan 18 Hilversum, Netherlands, 1217 CV NetherlandsPartners4Access are experts in orphan drug, cell and gene therapy access, partnering with the biotechnology industry to support launches worldwide. Our services focus on four key areas: Evidence Mitigation Solutions, Value Communications, Route to Market & Pricing and Access Performance. As one of the only consultancies with comprehensive experience in cell and gene therapies, P4A are excellently placed to help clients successfully achieve access. Through various media initiatives, P4A are able to inform and shape the conversation around orphan drugs. The team at P4A believe in striking an equilibrium in the rare disease world. That means helping drive access to the most appropriate treatments for patients and physicians, a fair return on investment for manufacturers at an affordable proposition for payers.

Partners 4 Access

Boslaan 18 Boslaan 18 Hilversum, Netherlands, 1217 CV NetherlandsPartners4Access are experts in orphan drug, cell and gene therapy access, partnering with the biotechnology industry to support launches worldwide. Our services focus on four key areas: Evidence Mitigation Solutions, Value Communications, Route to Market & Pricing and Access Performance. As one of the only consultancies with comprehensive experience in cell and gene therapies, P4A are excellently placed to help clients successfully achieve access. Through various media initiatives, P4A are able to inform and shape the conversation around orphan drugs. The team at P4A believe in striking an equilibrium in the rare disease world. That means helping drive access to the most appropriate treatments for patients and physicians, a fair return on investment for manufacturers at an affordable proposition for payers.

Partners 4 Access

Boslaan 18 Boslaan 18 Hilversum, Netherlands, 1217 CV NetherlandsPartners4Access are experts in orphan drug, cell and gene therapy access, partnering with the biotechnology industry to support launches worldwide. Our services focus on four key areas: Evidence Mitigation Solutions, Value Communications, Route to Market & Pricing and Access Performance. As one of the only consultancies with comprehensive experience in cell and gene therapies, P4A are excellently placed to help clients successfully achieve access. Through various media initiatives, P4A are able to inform and shape the conversation around orphan drugs. The team at P4A believe in striking an equilibrium in the rare disease world. That means helping drive access to the most appropriate treatments for patients and physicians, a fair return on investment for manufacturers at an affordable proposition for payers.

Precision Medicine Lab

Industrielaan 63 Oss, Noord-brabant, 5349AE NetherlandsPrecision Medicine Lab is a Dutch life sciences company active in the field of identification of drug-like molecules from natural sources and is focusing its discovery and drug-development activities in the field of nuclear receptors which represent one of the most important targets for therapeutic drug development. The company uses its novel co-activator and co-repressor and nuclear receptor activity lab-on-a-chip (NAPing) platform to identify and optimize novel drugs affecting nuclear receptors.

Pyxis Discovery

Delftechpark 26Pyxis Discovery offers compound librariers, fragment libraries, medicinal chemistry, and protease screening.

PlantResearch BV

11 Stelvenseweg Made, NB, 4921 PL NetherlandsPlantResearch BV is an independent, privately owned research company that specializes in the development and testing of growing media, fertilizers and plant bio-stimulants for both conventional and organic horticulture. The majority of our clients are companies that wish to develop or improve products or application methods for the EU and world markets. Our research is both fundamental and practical, undertaken in our purpose built greenhouse facilities and modern laboratory. The main focus of our work is the development and testing of growing media, (organic) fertilizers as well as growth enhancing products and technologies. In addition to the development of new products PlantResearch can also assists its clients in registering their products with relevant certifying agencies worldwide.

PRA Health Sciences

Westerbrink 3At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

PRA Health Sciences

Berkenweg 1At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

PRA Health Sciences

Stationsweg 163At PRA Health Sciences, providing innovative solutions for our clients is what we do. But innovation just for the sake of innovation isn’t why we do it. Side-by-side with our clients, we strive to move drug discovery forward, to help them develop life-saving and life- improving drugs. We help change people’s lives for the better every single day. It’s who we are. Innovating to help people is at the heart of our process, but it’s even more than that. It’s also our privilege.

PET Power

Hermelijnweg Etten-Leur, NB, 4877 AE NetherlandsPET Power supplies bottles and jars and also provides appropriate lids and decorations.

Pivot Park Screening Centre

Kloosterstraat 9 5349 AB Oss The NetherlandsPivot Park Screening Centre (PPSC) is a high-quality CRO and your optimal partner in early drug discovery. At PPSC we provide drug discovery services in the fields of assay development, lab automation, Ultra-High-Throughput Screening (uHTS) and hit-to-lead biological profiling, in order to find novel leads for drug development. PPSC was the first CRO offering mass spectrometry readout in 1536-well plates uHTS campaigns and has ample experience in uHTS Mass Spectrometry campaigns. Besides our MS capabilities, we also have multiple read-out options online, enabling flexibility to deliver the best QHL for our customers. Our customers use our compound library (~310K compounds) or we can use their library (we can store 2,5 Mio compounds online). Our state-of-the-art facility enables us to deliver up to 300K data points per day: we combine high speed with high quality.

Pivot Park Screening Centre

Kloosterstraat 9 Oss, 5349AB NetherlandsPivot Park Screening Centre (PPSC) is a high-quality CRO and your optimal partner in early drug discovery. At PPSC we provide drug discovery services in the fields of assay development, lab automation, Ultra-High-Throughput Screening (uHTS) and hit-to-lead biological profiling, in order to find novel leads for drug development. PPSC was the first CRO offering mass spectrometry readout in 1536-well plates uHTS campaigns and has ample experience in uHTS Mass Spectrometry campaigns. Besides our MS capabilities, we also have multiple read-out options online, enabling flexibility to deliver the best QHL for our customers. Our customers use our compound library (~310K compounds) or we can use their library (we can store 2,5 Mio compounds online). Our state-of-the-art facility enables us to deliver up to 300K data points per day: we combine high speed with high quality.

QM Diagnostics

Transistorweg 5 Nijmegen, 6534AT NetherlandsHealth monitoring of small laboratory animals used for biomedical research.

QVQ

1 Yalelaan Utrecht, UT, 3584 CL NetherlandsQVQ aims at supplying single domain antibody services to research groups and companies providing the smallest, fastest and most effective antibody based research, therapeutic or imaging agents in the market. In collaboration with our customer, we provide services according to their specific requirements. In tailor-made projects with a high level of interaction with the customer, we develop a perfectly suited imaging agent.

QVQ

1 Yalelaan Utrecht, UT, 3584 CL NetherlandsQVQ aims at supplying single domain antibody services to research groups and companies providing the smallest, fastest and most effective antibody based research, therapeutic or imaging agents in the market. In collaboration with our customer, we provide services according to their specific requirements. In tailor-made projects with a high level of interaction with the customer, we develop a perfectly suited imaging agent.

QVQ

Yalelaan 1 Androclus building Utrecht, UT, 3584 CL NetherlandsQVQ aims at supplying single domain antibody services to research groups and companies providing the smallest, fastest and most effective antibody based research, therapeutic or imaging agents in the market. In collaboration with our customer, we provide services according to their specific requirements. In tailor-made projects with a high level of interaction with the customer, we develop a perfectly suited imaging agent.

Quest Pharmaceutical Services

Petrus Campersingel 123QPS provides bioanalytical LC/MS/MS services, immunoanalytical services, biomarker discovery services, and in vitro and in vivo ADME services.

QPS

Petrus Campersingel 123 Groningen, The Netherlands 9713 AGCustom-Built Research Services with remarkable flexibility, agility and speed. Contact QPS today! QPS is a global contract research organization (CRO) delivering the highest grade of discovery, preclinical, and clinical drug development services. Since 1995, QPS has rapidly expanded from a tiny bioanalysis shop to a full-service CRO with 1100+ employees in the US, Europe, Asia. Today, it offers expanded pharmaceutical contract Research & Development services with special expertise in Neuropharmacology, Toxicology, DMPK, Bioanalysis, Translational Medicine, as well as Clinical Trials and Clinical Research Services. Through continual enhancements in capacities and resources, QPS stands tall in its commitment to deliver superior quality, skilled performance and trusted service to its valued customers. In 2020, QPS celebrates 25 years in business, adding CLIA-certified and GLP-compliant laboratories ready to provide coronavirus testing assays and support coronavirus vaccine and therapy programs.

QVQ Holding BV

Yalelaan 1 Androclus building Utrecht, UT, 3584 CL NetherlandsQVQ contributes to the accurate and sensitive detection of diseases in the early stages by providing top quality validated Imaging and Research Agents based on their C-direct labelled single domain antibodies from camelids (professionally called functionalized VHH). To become a supplier of top-end market products, QVQ closely works together with top academic and industrial groups and actively stimulates research in these areas.

QuickZyme Biosciences

Zernikedreef 9QuickZyme Biosciences, a provider of research materials and preclinical assay services, offers unique products and services with added value in the field of matrix related proteins, enzymes and assays.

QuickZyme Biosciences

Zernikedreef 9 Leiden, 2333 CK NetherlandsQuickZyme Biosciences, a provider of research materials and preclinical assay services, offers unique products and services with added value in the field of matrix related proteins, enzymes and assays.

RIVM National Institute of Public Health

Bilthoven, UT NetherlandsRijksinstituut voor Volksgezondheid en Milieu (RIVM) or the National Institute of Public Health focuses on research.

Radboud University Nijmegen Centre for Molecular and Biomolecular Informatics

6500 HC NijmegenRadboud University Nijmegen Centre for Molecular and Biomolecular Informatics provides synthesis planning, visualization tools, modeling and computation chemistry services.

R C Hartelust BV

112B Kapelmeesterlaan Tilburg, NB, 5049 NL Netherlands

Radboud University Nijmegen Medical Centre

10 Geert Grooteplein Zuid, Nijmegen, GE 6525 GA, NLThe Radboud university medical center advances human knowledge by conducting biomedical, translational and clinical research in order to improve wellbeing. Our key strength is medical life sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboud university medical center is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine. The Radboud university medical center focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Radboud University Nijmegen Medical Centre

6525 GA Nijmegen Geert Grooteplein , zuid 10 NetherlandsThe Radboud university medical center advances human knowledge by conducting biomedical, translational and clinical research in order to improve wellbeing. Our key strength is medical life sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The Radboud university medical center is therefore uniquely positioned in the emerging Euregio and Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalised medicine. The Radboud university medical center focuses on scientific health challenges of today, with an eye on emerging diseases of the future.

Rijk Zwaan

9 Eerste Kruisweg Fijnaart, NB, 4793 RS NetherlandsRijk Zwaan develops vegetable varieties and sells the seeds produced from them, which places us right at the start of the food chain. Market position In the worldwide market of vegetable seeds, Rijk Zwaan is at the fifth place with a turnover of over 350 million euros. Every year, we invest 30% of our turnover in R&D.

ServiceXS

Plesmanlaan 1dServiceXS is an ISO17025 accredited laboratory providing Next-Gen Sequencing, genotyping, methylation and microarray services.

Swammerdam Institute for Life Sciences

University of Amsterdam Centre for Advanced Microscopy building III, room 2.11 Kruislaan 316 SM Amsterdam 1098 The NetherlandsSwammerdam Institute for Life Sciences offers optical microscopy for scientific research.

SynCon International

Amsterdam, the NetherlandsSynCon International offers clinical research services including feasibility analysis, site identification, patient recruitment, data management, and clinical monitoring.

Signifix

Professor Bronkhorstlaan 10 building 48 Bilthoven, 3723 MB The NetherlandsSignifix offers quality assurance/control and regulatory affairs expertise.

Sinensis Life Sciences

Archimedesweg 23 Leiden, 2333 CM The NetherlandsSinensis Life Sciences is an independent provider of laboratory testing and manufacturing services to the international life sciences market. Sinensis’ services range from (bio)chemical and microbiological quality control testing of pharmaceutical raw materials to finished dosage forms, thereby covering release, stability and validation studies. Method development departments can develop custom test methods from scratch or based on client methods.

Sinensis Life Sciences

Leiden, ZH NetherlandsSinensis Life Sciences is an independent provider of laboratory testing and manufacturing services to the international life sciences market. Sinensis’ services range from (bio)chemical and microbiological quality control testing of pharmaceutical raw materials to finished dosage forms, thereby covering release, stability and validation studies. Method development departments can develop custom test methods from scratch or based on client methods.

Seed Processing Holland BV

P.O. Box 32, 1600 AA Enkhuizen, The NetherlandsMission Statement “ To supply worldwide vegetable and flower seed companies with high quality and safe seed processing equipment and installations which give an added value to seeds and the process efficiency ” Welcome to Seed Processing Holland B.V. Based in Enkhuizen, Seed Processing Holland was founded in the year 1967 and has specialised in the manufacture of machinery and equipment for the seed processing industry. Seed processing Holland Inc. Seed Processing Holland (SPH) has expand its activities by opening up its Seed Processing Holland Inc. (SPH) Sales Office in the US in 2014. SPH recognizes the importance of the North American seed market and it has always been our wish to enhance our service level to this region by having a direct presence. We believe in the high value of working side by side with customers and this new US platform will enable SPH to do so and bring the right solutions to any seed processing and packaging need. Jeffrey runs the SPH office in the US.

Seed Processing Holland BV

Enkhuizenstraat Arnhem, GE, 6843 NetherlandsMission Statement “ To supply worldwide vegetable and flower seed companies with high quality and safe seed processing equipment and installations which give an added value to seeds and the process efficiency ” Welcome to Seed Processing Holland B.V. Based in Enkhuizen, Seed Processing Holland was founded in the year 1967 and has specialised in the manufacture of machinery and equipment for the seed processing industry. Seed processing Holland Inc. Seed Processing Holland (SPH) has expand its activities by opening up its Seed Processing Holland Inc. (SPH) Sales Office in the US in 2014. SPH recognizes the importance of the North American seed market and it has always been our wish to enhance our service level to this region by having a direct presence. We believe in the high value of working side by side with customers and this new US platform will enable SPH to do so and bring the right solutions to any seed processing and packaging need. Jeffrey runs the SPH office in the US.

SACHEM

Van Voordenpark 15SACHEM provides compound synthesis, reagents, catalysts, and chemical services.

Synexa Life Sciences

107 Regus Building 32 Mendelweg Leiden Bioscience Park Leiden, 2333CS NetherlandsSynexa is a global leader in biomarker and bioanalytical science, with deep expertise in the immunological underpinning of health and disease. We offer a comprehensive range of analytical and advisory services to clients comprising the identification, development, validation, analysis and interpretation of biomarker and bioanalytical readouts in translational and clinical research. Our developing global network of labs serve our client base of primarily Biotech and Pharma companies, either directly or via a CRO. We are dedicated to providing quality, clinically relevant solutions, and all activities across all our sites are performed in compliance with GCLP which incorporate the relevant GCP/GLP guidelines, under the guidance and watchful eyes of our Quality Assurance team.

Sylphium Life Sciences

Duurswoldlaan 22Sylphium Life Sciences offers DNA fragment subcloning, synthesis, PCR, modification, and cytochrome P450 expertise services.

Sylphium Life Sciences

Groningen, GR NetherlandsSylphium Life Sciences offers DNA fragment subcloning, synthesis, PCR, modification, and cytochrome P450 expertise services.

Symeres

Vliesvenweg 1 Weert, 6002 NM NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Symeres

Vliesvenweg 1 Weert, 6002 NM NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Symeres

Vliesvenweg 1 Weert, 6002 NM NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Symeres

Kerkenbos 1013 Nijmegen, 6546 NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Symeres

Kadijk Groningen, 9747 AT NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Symeres

Kerkenbos 1013 Nijmegen, 6546 BB NetherlandsSymeres, formerly MercachemSyncom, is the leading mid-sized European contract research organization offering innovative chemistry, medicinal chemistry, ADME/tox, PK, early process research services, and GMP production to accelerate the drug discovery and development process in a flexible and cost-effective way. Symeres also offers integrated drug-discovery services from hit to clinic via multiple-platform strategic alliances under a single MSA. Working for many pharmaceutical and biotech companies throughout the world, Symeres is recognized for its high-quality products and services and its unprecedented problem-solving capabilities. Symeres is the result of the fusion of four leading European contract research organizations. We have around 500 scientists at six locations (Groningen, Nijmegen, & Weert in the Netherlands, Prague in the Czech Republic, Oulu in Finland and Södertälje in Sweden)

Synthon B.V.

Microweg 22, 6545 CM Nijmegen, NetherlandsSynthon is a company committed to delivering affordable medicines through innovative science.

SynCo Bio Partners

Paasheuvelweg 30SynCo Bio Partners offers process development, microbial production, mammalian cell based production, and API synthesis services.

SMS-oncology

Science Park 406 Amsterdam, 1098 XH The NetherlandsSMS-oncology offers clinical research services to support clinical development of oncology therapeutics.

SkylineDx BV

Lichtenauerlaan 40 Rotterdam, Rotterdam, 3062ME NetherlandsSkylineDx is a biotechnology company, focused on research & development of molecular diagnostics in oncology and inflammatory diseases. The company is headquartered in Rotterdam (the Netherlands) and complemented with a field medical and scientific affairs team in the US and a CAP/CLIA certified laboratory in San Diego (California). SkylineDx uses its expertise to bridge the gap between academically discovered gene expression signatures and commercially available diagnostic products with high clinical utility, assisting healthcare professionals in accurately determining the type or status of disease or predict a patient’s response to treatment. Based on test results, healthcare professionals can tailor the treatment approach to the individual patient.

SkylineDx BV

Lichtenauerlaan 40 Rotterdam, Rotterdam, 3062ME NetherlandsSkylineDx is a biotechnology company, focused on research & development of molecular diagnostics in oncology and inflammatory diseases. The company is headquartered in Rotterdam (the Netherlands) and complemented with a field medical and scientific affairs team in the US and a CAP/CLIA certified laboratory in San Diego (California). SkylineDx uses its expertise to bridge the gap between academically discovered gene expression signatures and commercially available diagnostic products with high clinical utility, assisting healthcare professionals in accurately determining the type or status of disease or predict a patient’s response to treatment. Based on test results, healthcare professionals can tailor the treatment approach to the individual patient.

Single Cell Discoveries B.V.

Uppsalalaan 8 Utrecht, UT, 3584 CT NetherlandsSingle Cell Discoveries is your all-in-one CRO for single-cell sequencing. We focus on single-cell RNA sequencing only, so we we are the go-to partner for all your single-cell projects. With different single-cell) technologies in our portfolio, we always have a solution that suits your requirements. In our full-service model, we always include preliminary data analysis for our projects. Upon request, our PhD-level bioinformatics team can provide additional data analysis services that meet your custom requirements. Contact us to learn about the technologies we offer and how we can help you can accelerate your research. Technology portfolio: 10x Genomics High-throughput single-cell gene expression or single-cell immune profiling. Effortlessly analyze thousands of single cells per sample, for a low cost per cell. Available 10x Genomics services are: Single Cell Gene Expression and Single Cell Immune Profiling. SORT-seq SORT-seq is a cost-effective single-cell transcriptomics technology based on FACS sorting and 384-well plates. SORT-seq is a partially robotized version of the CEL-seq2 protocol. VASA-seq VASA-seq is a brand-new technology for full-length, total RNA sequencing at single-cell level. Like SORT-seq, VASA-seq is based on FACS sorting and 384-well cell capture plates.

Shimadzu

Australielaan 14Shimadzu offers analytical technology, laboratory instruments, testing machines, and scales.

Synvolux Therapeutics

L.J.Zielstraweg 1 9713 GX Groningen The NetherlandsSynvolux Therapeutics provide scientists with transfection reagents.

Synvolux Therapeutics

Groningen, GR NetherlandsSynvolux Therapeutics provide scientists with transfection reagents.

Sensus

Borchwerf 3 Roosendaal, 4704 RG NetherlandsSensus specializes in the production of Frutafit inulin and Frualose oligofructose.

Sylics

1081 HV, Amsterdam, The NetherlandsSylics provides in vivo neuroscience research solutions for preclinical testing of new therapies of CNS and muscle diseases. Please visit our website for a comprehensive list of mouse models and analyses services. The goal of Sylics’ preclinical CRO activities is to produce conclusive and reproducible results in a transparent way, while ensuring animal use and care according to European standards. Our experienced scientific team invests time in understanding our customer’s needs and provides input based on strong preclinical research expertise. Over the last 15+ years, we provided efficacy studies in our mouse and rat models to biotech, academic, top 10 big pharma, and food industry clients.

Sylics

VU Campus, W&N building Tav. Maarten Loos, Room B559 De Boelelaan 1085 Amsterdam, North Holland, 1081HV NetherlandsSylics provides in vivo neuroscience research solutions for preclinical testing of new therapies of CNS and muscle diseases. Please visit our website for a comprehensive list of mouse models and analyses services. The goal of Sylics’ preclinical CRO activities is to produce conclusive and reproducible results in a transparent way, while ensuring animal use and care according to European standards. Our experienced scientific team invests time in understanding our customer’s needs and provides input based on strong preclinical research expertise. Over the last 15+ years, we provided efficacy studies in our mouse and rat models to biotech, academic, top 10 big pharma, and food industry clients.

Sylics

PSP campus, Building D6, Postbox 86 Antonie van Leeuwenhoeklaan 9-13 Bilthoven, UT, 3721 MA NetherlandsSylics provides in vivo neuroscience research solutions for preclinical testing of new therapies of CNS and muscle diseases. Please visit our website for a comprehensive list of mouse models and analyses services. The goal of Sylics’ preclinical CRO activities is to produce conclusive and reproducible results in a transparent way, while ensuring animal use and care according to European standards. Our experienced scientific team invests time in understanding our customer’s needs and provides input based on strong preclinical research expertise. Over the last 15+ years, we provided efficacy studies in our mouse and rat models to biotech, academic, top 10 big pharma, and food industry clients.

Sylics

Amsterdam, NH NetherlandsSylics provides in vivo neuroscience research solutions for preclinical testing of new therapies of CNS and muscle diseases. Please visit our website for a comprehensive list of mouse models and analyses services. The goal of Sylics’ preclinical CRO activities is to produce conclusive and reproducible results in a transparent way, while ensuring animal use and care according to European standards. Our experienced scientific team invests time in understanding our customer’s needs and provides input based on strong preclinical research expertise. Over the last 15+ years, we provided efficacy studies in our mouse and rat models to biotech, academic, top 10 big pharma, and food industry clients.

Spinnovation

Toernooiveld 1, Mercator III Nijmegen, 6525 ED The NetherlandsSpinnovation offers high resolution NMR and MS services to support structure elucidation, impurity profiling, metabolite identification, and target-ligand interaction studies.

Spinnovation

Nijmegen, GE NetherlandsSpinnovation offers high resolution NMR and MS services to support structure elucidation, impurity profiling, metabolite identification, and target-ligand interaction studies.

Specs

Kluyverweg 6 2629HT Delft, The NetherlandsSpecs offers compound management services, compound libraries, contract research, custom synthesis,cheminformatics, compound sourcing, building blocks and natural products.

Specs

Bleiswijkseweg 55 Zoetermeer, 2712 PB NetherlandsSpecs offers compound management services, compound libraries, contract research, custom synthesis,cheminformatics, compound sourcing, building blocks and natural products.

Sanbio

Frontstraat 2c 5405 PB Uden The NetherlandsSanbio B.V., based in Uden (the Netherlands) and established in 1978, is an independent supplier of life science products for research and diagnostics in the Benelux and represents a large number of innovative international companies. Sanbio is also manufacturer and developer of antibodies and antibody-related products of its own brand Monosan, suitable for basic and applied life sciences projects. Our strong reputation is built on our aim to serve our customers with the highest level of service and support.

Shanghai Medicilon

Kelvinstraat 41b Wijchen, GLD, 6601 HH NetherlandsAt Medicilon, we are dedicated to help our clients develop their research and discovery programs from a burst of ideas all the way through the Investigational New Drug (IND) filing phase. Our services span across medicinal chemistry, biology, API, CMC, formulation, and preclinical studies. We provide flexible business models, including stand-alone Fee For Services (FFS) and fully integrated FTE services. In addition, our facilities are GLP/GMP compliant and AAALAC accredited. All study reports can be presented in SEND format, supporting dual filing of IND applications in the US, EU, and China.

Sanquin

Plesmanlaan 125Sanquin offers blood testing and immunodiagnostic services.

Sanquin

Plesmanlaan 125 Amsterdam, North Holland, 1066CX NetherlandsSanquin offers blood testing and immunodiagnostic services.

Sanquin

Plesmanlaan 125 Amsterdam, 1066 CX NetherlandsSanquin offers blood testing and immunodiagnostic services.

Tagworks Pharmaceuticals BV

c/o Radboud University Medical Center Department of Nuclear Medicine and Radiology (route 766) P.O. Box 9101 Nijmegen, 6500 HB Netherlandsagworks Pharmaceuticals is a privately held pharmaceutical company based in Eindhoven, The Netherlands, focused on the in vivo assembly and actuation of diagnostic and therapeutic antibody conjugates. Founded in 2011, Tagworks is a spin-out of Royal Philips Electronics, and originates from Philips’ molecular imaging expertise. The Company is located at the High Tech Campus in the Center for Imaging Research and Education (CIRE), which is a shared life science facility between Philips, the Technical University Eindhoven, and third parties. The >2000 m2 infrastructure at CIRE, supported by dedicated scientists and technicians, includes organic and protein chemistry, molecular and cell biology, radiochemistry, and imaging labs. In addition, the Company works with several CRO partners.

Taiwan Liposome Company, Ltd. (TLC)

19 J.H. Oortweg Leiden, ZH, 2333 NetherlandsTaiwan Liposome Company (TLC) is a biopharmaceutical company focused on the research, development and commercialization of innovative pharmaceutical products based on its proprietary drug delivery technologies. Our strengths lie in lipid-based formulation and scale-up for parenteral drugs using micelles and nanoparticles to optimize the pharmacokinetics of drugs for better efficacy and lower toxicity, and thus prolong the product lifecycle of branded drugs. Vision TLC is dedicated to maximizing the benefits of medications for patients and improving their quality of life through constantly advancing our technology & know-how. Mission TLC strives to become a global leading biopharmaceutical company, to contribute more towards making a difference in the healthcare industry and make Taiwan biotechnology industry visible in the global arena.

Triskelion BV

Reactorweg 47A Utrecht, 3542AD NetherlandsTRISKELION fully supports this vision by offering testing and consultancy services to clients in the pharmaceutical, food, feed and (agro)chemical industries. Together, we drive our mission to improve human, animal and environmental health by “contributing to safe and sustainably-produced food, pharmaceutical and (agro)chemical products.” TRISKELION has unique capabilities when it comes to applying the necessary interdisciplinary and cross-sectorial approach. With our technical expertise, highly knowledgeable teams and bespoke solutions, we’re able to fully utilize our capabilities in determining the properties of any food, pharmaceutical or (agro)chemical product. We’re able to support you with knowledge and consultancy on appropriate legislation and regulations, as well as best practices in GLP and GMP processes.

Triskelion BV

P.O. Box 844, 3700 AV Zeist, The Netherlands.TRISKELION fully supports this vision by offering testing and consultancy services to clients in the pharmaceutical, food, feed and (agro)chemical industries. Together, we drive our mission to improve human, animal and environmental health by “contributing to safe and sustainably-produced food, pharmaceutical and (agro)chemical products.” TRISKELION has unique capabilities when it comes to applying the necessary interdisciplinary and cross-sectorial approach. With our technical expertise, highly knowledgeable teams and bespoke solutions, we’re able to fully utilize our capabilities in determining the properties of any food, pharmaceutical or (agro)chemical product. We’re able to support you with knowledge and consultancy on appropriate legislation and regulations, as well as best practices in GLP and GMP processes.

Triskelion BV

Utrechtseweg 48, 3704 HE ZeistTRISKELION fully supports this vision by offering testing and consultancy services to clients in the pharmaceutical, food, feed and (agro)chemical industries. Together, we drive our mission to improve human, animal and environmental health by “contributing to safe and sustainably-produced food, pharmaceutical and (agro)chemical products.” TRISKELION has unique capabilities when it comes to applying the necessary interdisciplinary and cross-sectorial approach. With our technical expertise, highly knowledgeable teams and bespoke solutions, we’re able to fully utilize our capabilities in determining the properties of any food, pharmaceutical or (agro)chemical product. We’re able to support you with knowledge and consultancy on appropriate legislation and regulations, as well as best practices in GLP and GMP processes.

Theorem Clinical Research

Fazantlaan 23 5613 CB Eindhoven NetherlandsTheorem Clinical Research offers full service clinical research solutions including DM, biostatistics, programming including CDISC, PM, clinical operations, and regulatory affairs.

Telstar Life Science Solutions

Kuipersweg 37Telstar Life Science Solutions designs, manufactures, sell and support of high technology equipment solutions for the pharmaceutical, biotech and related industries

Telesis Pharma BV

Hofstraat 22 - 9712 JC Groningen, The NetherlandsTelesis Pharma BV is a pharmaceutical company working on the processes and chemistry of drugs. We are developing improved drug synthesis to reduce costs significantly while maintaining the high quality standards. This way we help our customers offer highly competitive drug products and therefore contribute to the accessibility of medicine to all.

Telesis Pharma BV

Hofstraat 22 - 9712 JC Groningen NetherlandsTelesis Pharma BV is a pharmaceutical company working on the processes and chemistry of drugs. We are developing improved drug synthesis to reduce costs significantly while maintaining the high quality standards. This way we help our customers offer highly competitive drug products and therefore contribute to the accessibility of medicine to all.

The Hyve

The Hyve (Het Nieuwe Kantoor) Arthur van Schendelstraat 650 3511 MJ Utrecht The NetherlandsThe Hyve is a young, innovative and fast growing company with a mix of software engineers, bioinformaticians and data scientists. We focus on developing web applications that visualize large amounts of biological and clinical data. We work together with pharmaceutical companies, hospitals, universities and IT companies for a shared solution for data integration and visualization. We are dedicated to support scientists in life sciences and healthcare R&D with open source software, open data and open standards. We are highly motivated to find the solution for your next problem. We want companies in the life sciences sector to leverage open source software already available to improve the methods of research. Our ultimate goal is enhance the quality and impact of biology by enabling scientist to publish their bioinformatics data.

The Hyve

The Hyve (Het Nieuwe Kantoor) Arthur van Schendelstraat 650 Utrecht, 3511 MJ NetherlandsThe Hyve is a young, innovative and fast growing company with a mix of software engineers, bioinformaticians and data scientists. We focus on developing web applications that visualize large amounts of biological and clinical data. We work together with pharmaceutical companies, hospitals, universities and IT companies for a shared solution for data integration and visualization. We are dedicated to support scientists in life sciences and healthcare R&D with open source software, open data and open standards. We are highly motivated to find the solution for your next problem. We want companies in the life sciences sector to leverage open source software already available to improve the methods of research. Our ultimate goal is enhance the quality and impact of biology by enabling scientist to publish their bioinformatics data.

Toxys

De Limes 7 Oegstgeest, Zuid-Holland, 2342 DH NetherlandsToxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. Toxys exclusively offers the ToxTracker assay, our state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the genotoxic properties of pharmaceutical compounds and chemicals. ToxTracker can contribute to a mechanism-based, animal-free, cancer hazard and risk assessment of chemicals. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes of action and a number of non-genotoxic modes of action, such as oxidative stress and protein damage. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays. Toxys also offers ToxTracker ACE (Aneugen Clastogen Evaluation) being an extended version of ToxTracker assay and includes direct discrimination between an aneugenic and a clastogenic mode-of-action of genotoxic compounds. Based on our (scientific) expertise Toxys has developed ReproTracker. ReproTracker® is a state-of-the-art in vitro assay to visualise the key events during early embryonic development that allows for a reliable assessment of developmental toxicity hazards of new drugs and chemicals. ReproTracker® is a human induced pluripotent stem cell (hiPSC)-based assay that assesses key events during stem cell differentiation. The assay is able to identify compounds that interfere with early embryonic development. In 2020 TubulinTracker was launched. TubulinTracker is a novel in vitro assay using GFP-tagged Tubulin, that allows the direct visualisation of the microtubules using either live cell microscopy to follow the dynamics during the cell cycle or flow cytometry. The assay can be applied to study the effects of compounds on microtubule stability as well as assess the effect on the cell cycle progression and induction of aneuploidy. TubulinTracker can discriminate between Tubulin stabilising and Tubulin destabilising substances and provides more insight into the cause of aneuploidy upon exposure. In 2021 we licensed in technology that formed the basis of ToxProfiler, an assay for mechanistic toxicity testing. ToxProfiler is a unique New Approach Method (NAM) that can be applied to accurately quantify the cellular stress responses induced by chemicals. The assay can be applied to reveal the toxicological mode-of-action (MoA) of novel medicines, (agro)chemicals, cosmetics and food ingredients. ToxProfiler consists of 7 genetically engineered HepG2 cell lines. Each cell line contains a specific fluorescent reporter that is associated with a specific cellular stress response pathway. All fluorescent reporters are expressed at physiological levels and reflect the endogenous cellular stress responses. Automated live-cell confocal microscopy and image segmentation pipelines are applied to generate a toxicological fingerprint for each compound representing the cellular stress responses that are activated upon exposure. ToxProfiler is particularly applicable for early chemical safety testing by providing insight into the toxic MoA of compounds, as well as read-across, adverse outcome pathway (AOP) and weight-of-evidence (WoE) approaches.

Toxys

Robert Boyleweg 4 Leiden, 2333 CG NetherlandsToxys is a Dutch biotech company that provides innovative in vitro toxicity screening solutions to rapidly identify hazardous and potential carcinogenic properties of novel compounds during the early phases of product and drug development. Toxys exclusively offers the ToxTracker assay, our state-of-the-art stem cell-based reporter assay that provides mechanistic insights into the genotoxic properties of pharmaceutical compounds and chemicals. ToxTracker can contribute to a mechanism-based, animal-free, cancer hazard and risk assessment of chemicals. ToxTracker can be particularly useful in an Adverse Outcome Pathway (AOP) approach for both genotoxic and non-genotoxic carcinogens by revealing genotoxic modes of action and a number of non-genotoxic modes of action, such as oxidative stress and protein damage. We often combine our unique ToxTracker assay with a range of extended protocols and additional assays to unravel the underlying mechanism of genotoxicity and predict the outcomes in the regulatory in vitro and in vivo genotoxicity assays. Toxys also offers ToxTracker ACE (Aneugen Clastogen Evaluation) being an extended version of ToxTracker assay and includes direct discrimination between an aneugenic and a clastogenic mode-of-action of genotoxic compounds. Based on our (scientific) expertise Toxys has developed ReproTracker. ReproTracker® is a state-of-the-art in vitro assay to visualise the key events during early embryonic development that allows for a reliable assessment of developmental toxicity hazards of new drugs and chemicals. ReproTracker® is a human induced pluripotent stem cell (hiPSC)-based assay that assesses key events during stem cell differentiation. The assay is able to identify compounds that interfere with early embryonic development. In 2020 TubulinTracker was launched. TubulinTracker is a novel in vitro assay using GFP-tagged Tubulin, that allows the direct visualisation of the microtubules using either live cell microscopy to follow the dynamics during the cell cycle or flow cytometry. The assay can be applied to study the effects of compounds on microtubule stability as well as assess the effect on the cell cycle progression and induction of aneuploidy. TubulinTracker can discriminate between Tubulin stabilising and Tubulin destabilising substances and provides more insight into the cause of aneuploidy upon exposure. In 2021 we licensed in technology that formed the basis of ToxProfiler, an assay for mechanistic toxicity testing. ToxProfiler is a unique New Approach Method (NAM) that can be applied to accurately quantify the cellular stress responses induced by chemicals. The assay can be applied to reveal the toxicological mode-of-action (MoA) of novel medicines, (agro)chemicals, cosmetics and food ingredients. ToxProfiler consists of 7 genetically engineered HepG2 cell lines. Each cell line contains a specific fluorescent reporter that is associated with a specific cellular stress response pathway. All fluorescent reporters are expressed at physiological levels and reflect the endogenous cellular stress responses. Automated live-cell confocal microscopy and image segmentation pipelines are applied to generate a toxicological fingerprint for each compound representing the cellular stress responses that are activated upon exposure. ToxProfiler is particularly applicable for early chemical safety testing by providing insight into the toxic MoA of compounds, as well as read-across, adverse outcome pathway (AOP) and weight-of-evidence (WoE) approaches.

Utrecht University

Utrecht, UT NetherlandsUtrecht University performs academic research.

University Medical Center Utrecht

100 Heidelberglaan Utrecht, UT, 3584 CX NetherlandsCare, research and education are the three mainstays of UMC Utrecht. These mainstays are inextricably intertwined in our ongoing efforts to improve people's health. Leading scientific research, groundbreaking innovation and collaboration with patients and other interested parties form the basis of our first-rate healthcare. UMC Utrecht is quick and eager to put improvements into practice. High-quality education guarantees the influx of new talent required to maintain and strengthen our position at the forefront of healthcare.

University Medical Center Groningen

Hanzeplein 1 Groningen, 9713 GZ NetherlandsThe University Medical Center Groningen (UMCG) was established in 2005 as a joint activity of the University of Groningen and the Academic Hospital Groningen (AZG). At present, the UMCG is one of the largest hospitals in the Netherlands and the largest employer in the Northern Netherlands. More than 10,000 employees provide patient care, are involved in medical education and perform cutting-edge scientific research, focused on ‘healthy and active ageing’. Research and education at the UMCG are funded through the University of Groningen, and the Faculty of Medical Sciences functions as an integral part of the University. The Dean of the Faculty of Medicine is appointed by the Board of the University and is a member of the Board of Directors of the UMCG. More than 3,400 students of the University of Groningen study Medicine, Dentistry or Human Movement Sciences, while more than 340 physicians are doing their specialty training at the state of the art facilities of the UMCG. Patients attend the UMCG for basic care but also for very specialist diagnoses, examination or treatment. All patients from the Northern Netherlands with complicated or unusual disorders are eventually referred to the UMCG. Good quality care is always based on the latest information, and is provided by the best doctors and nurses. Together with the support staff, every day we work on achieving a single common goal: building the future of health.

Utrecht University National Single Crystal Service Facility

Utrecht University, Padualaan 8, 3584 CH Utrecht, The NetherlandsUtrecht University National Single Crystal Service Facility provides crystal structure determination services.

University of Groningen

7 Nijenborgh Groningen, GR, 9747 AG NetherlandsThe University of Groningen (legal entity) on behalf of the Electron Microscopy Unit (service provider) offers academic research collaboration and facility service jobs. The electron microscopy unit (hereinafter the Academic Core Facility / Labaratory) established 2017) headed by Cristina Paulino is located at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) in the Faculty of Science and Engineering of the University of Groningen. PLEASE NOTE: The Electron Microscopy Unit is the only department of the University working via this platform. Electron microscopy services include: negative stain and cryo-EM screening of samples and high-resolution data acquisition, image processing and consulting. The facility offers sample preparation tools, several screening TEMs (CM12, CM120, Tecnai 20), and a dedicated high-end Talos Arctica cryo-TEM equipped with an auto-loader, K2 summit DDD camera, energy filter and a phase plate and includes automated data recording software and on-the-fly data quality assessments tools. The group is specialised in the high-resolution determination of small membrane protein structures by single-particle cryo-EM.

University of Groningen

5 Broerstraat Groningen, GR, 9712 CP NetherlandsThe University of Groningen (legal entity) on behalf of the Electron Microscopy Unit (service provider) offers academic research collaboration and facility service jobs. The electron microscopy unit (hereinafter the Academic Core Facility / Labaratory) established 2017) headed by Cristina Paulino is located at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) in the Faculty of Science and Engineering of the University of Groningen. PLEASE NOTE: The Electron Microscopy Unit is the only department of the University working via this platform. Electron microscopy services include: negative stain and cryo-EM screening of samples and high-resolution data acquisition, image processing and consulting. The facility offers sample preparation tools, several screening TEMs (CM12, CM120, Tecnai 20), and a dedicated high-end Talos Arctica cryo-TEM equipped with an auto-loader, K2 summit DDD camera, energy filter and a phase plate and includes automated data recording software and on-the-fly data quality assessments tools. The group is specialised in the high-resolution determination of small membrane protein structures by single-particle cryo-EM.

UbiQ

Henriette Bosmansstraat 11UbiQ develops and commercializes ubiquitinated polypeptides and offers advanced high throughput assay reagents for drug discovery in the ubiquitin field.

U-CyTech

Yalelaan 48 Utrecht, 3584 CM The NetherlandsU-CyTech develops and manufactures a wide range of innovative cytokine ELISA, ELISPOT and Fluorospot systems for human, monkey and rodent use.

VU University Amsterdam, Department of Physics and Astronomy

Faculty of Sciences De Boelelaan 1081 NL-1081 HV Amsterdam The NetherlandsOur department consists of 25 research staff members, 4 (fte) teaching staff members, 6 technicians (exclusive the mechanical and electronic workshops), 75 postdocs and PhD students, and 350 students that follow bachelor and master degrees in Physics, Medical Natural Sciences and Science, Business and Innovation. Our research is organized in five research groups: Biophotonics & Medical Imaging Physics of Living Systems Biophysics / Physics of Energy Atoms, Molecules & Lasers Astro-Particle Physics Our department hosts a Physical Practica & Didactics group, responsible for the training of experimental skills of undergraduate students and the development of new didactical methods.

VU University Amsterdam, Department of Physics and Astronomy

1105 De Boelelaan Amsterdam, NH, 1081 HV NetherlandsOur department consists of 25 research staff members, 4 (fte) teaching staff members, 6 technicians (exclusive the mechanical and electronic workshops), 75 postdocs and PhD students, and 350 students that follow bachelor and master degrees in Physics, Medical Natural Sciences and Science, Business and Innovation. Our research is organized in five research groups: Biophotonics & Medical Imaging Physics of Living Systems Biophysics / Physics of Energy Atoms, Molecules & Lasers Astro-Particle Physics Our department hosts a Physical Practica & Didactics group, responsible for the training of experimental skills of undergraduate students and the development of new didactical methods.

Van Loon Chemical Innovations

408 Science Park Amsterdam, NH, 1098 XH NetherlandsVan Loon Chemical Innovations (VLCI) provides valuable and innovative R&D services to the formulation industry, on a project-by-project basis. By combining knowledge, experience and High Throughput, we boost development processes and improve properties of polymers, coatings, personal & beauty care, household and pharmaceutical products. VLCI has its own proven concept: Various products introduced onto the market up to 5 times faster, allowing our customers to save costs on R&D projects.

Virtual Proteins

High Tech Campus 9 Eindhoven 5656 AE The NetherlandsVirtual Proteins provides imaging and simulation services.

VU University Amsterdam - LaserLaB Amsterdam

LaserLaB VU University Amsterdam De Boelelaan 1081 1081 HV Amsterdam, The NetherlandsThe mission of LaserLaB Amsterdam is groundbreaking scientific research based on the interaction of light with matter, spanning from the research on atoms and molecules to the investigation of living cells and tissue and sustainable energy sources. Within LaserLaB, research is conducted in close collaboration between physicists, chemists, biologists and physicians. LaserLaB Amsterdam is hosted at the VU University, with participating research groups at the UvA, AMC and VUmc. LaserLaB is a founding partner of the new imaging center VU University medical imaging center. LaserLaB Amsterdam is part of LASERLAB-Europe, an Integrated Infrastructure Initiative of the European Union, forming a consortium of the 27 major laser centers in Europe. The discovery of the laser, 50 years ago, gave scientists access to beams of light of extremely high intensity and very short duration. The laser has become an unique tool for the research into the foundation of nature and life, such as photosynthesis, protein dynamics, chemical reactions and constants of nature. The research within LaserLaB is organized around the dominating societal needs, Human Health and Energy. Some 100 scientists are involved in laser-oriented scientific research of applied and fundamental nature. The increasing demand for health and longevity requires a better understanding of the basic processes of life. The LaserLaB research is focused on the development and application of novel optical methods, techniques and instruments to study the interaction between proteins, DNA, cells and tissue. This knowledge will lead to innovative diagnostic and therapeutic techniques. Energy production will play a crucial role in our future. The process of photosynthesis in plants serves as an example for renewable energy production. By studying this process, it is possible to develop more efficient solar cells or biofuels. The laser has made it possible to study the structure of living materials and matter and the chemical and physical processes that take place within them. The LaserLab will serve as a powerful multidisciplinary educational faculty, especially for national and international (Master's) students and will have a unique position in Europe.

VU University Amsterdam - LaserLaB Amsterdam

1105 De Boelelaan Amsterdam, NH, 1081 HV NetherlandsThe mission of LaserLaB Amsterdam is groundbreaking scientific research based on the interaction of light with matter, spanning from the research on atoms and molecules to the investigation of living cells and tissue and sustainable energy sources. Within LaserLaB, research is conducted in close collaboration between physicists, chemists, biologists and physicians. LaserLaB Amsterdam is hosted at the VU University, with participating research groups at the UvA, AMC and VUmc. LaserLaB is a founding partner of the new imaging center VU University medical imaging center. LaserLaB Amsterdam is part of LASERLAB-Europe, an Integrated Infrastructure Initiative of the European Union, forming a consortium of the 27 major laser centers in Europe. The discovery of the laser, 50 years ago, gave scientists access to beams of light of extremely high intensity and very short duration. The laser has become an unique tool for the research into the foundation of nature and life, such as photosynthesis, protein dynamics, chemical reactions and constants of nature. The research within LaserLaB is organized around the dominating societal needs, Human Health and Energy. Some 100 scientists are involved in laser-oriented scientific research of applied and fundamental nature. The increasing demand for health and longevity requires a better understanding of the basic processes of life. The LaserLaB research is focused on the development and application of novel optical methods, techniques and instruments to study the interaction between proteins, DNA, cells and tissue. This knowledge will lead to innovative diagnostic and therapeutic techniques. Energy production will play a crucial role in our future. The process of photosynthesis in plants serves as an example for renewable energy production. By studying this process, it is possible to develop more efficient solar cells or biofuels. The laser has made it possible to study the structure of living materials and matter and the chemical and physical processes that take place within them. The LaserLab will serve as a powerful multidisciplinary educational faculty, especially for national and international (Master's) students and will have a unique position in Europe.

Vivomicx BV

53 H.W. Mesdagstraat Groningen, GR, 9718 HD NetherlandsIsolation of cells from tissue sections. We developed a well validated protocol for analysing gene expression profiles in subsets of cells in complex tissues from animal and human origin. Using laser dissection microscopy, we isolate predestined cells from tissue sections and subject their RNA to quantitative RT-PCR analysis. It provides a unique way to unmask the molecular control of cell behaviour in different compartments of healthy and diseased tissues. Also, the effects of therapeutic intervention can be analysed at the molecular level in the cells you are interested in.

Viroclinics

Room Ee-1989 3015 GE Roterdam The NetherlandsViroclinics provides diagnostic testing, preclinical services, and research in virology and other related areas.

Van Iperen International

24 Smidsweg Westmaas, ZH, 3273 LK NetherlandsVan Iperen International can rely on the best expertise there is in the fertilizer sector. Not only do we belong to a business group with a respectable background and history, we are also connected to a network of serious knowledge. That is part of the reason why we can help your business grow. We know how to produce fertilizers, how to use them, and how to distribute them. And we would like to share this with you. Erik van den Bergh, our Managing Director, explains who we are and what our strengths are.

VU University Amsterdam, Department for Physics and Astronomy Biophysics of Photosynthesis/Energy

Amsterdam, NH, 1081 HV NetherlandsThe Biophysics group uses advanced optical spectroscopy and microscopy to obtain fundamental knowledge on the relation between the structure, function and dynamics of proteins and other biological molecules, both in single proteins and in supramolecular aggregates. Photosynthesis Photosynthesis converts energy from light into biological energy and is essential for all life on Earth. For successful operation it requires an integration of (sub-)picosecond photophysical and photochemical processes with developmental and regulatory processes that take place over much longer timescales. Understanding the basic principles that nature exploits in its solar energy converters is of utmost importance to develop new technologies for the production of clean and sustainable energy. We study photosynthesis by a variety of advanced laser-spectroscopic and microscopic techniques, also within the framework of a European Initial Training Network. Photoactive proteins, signal transduction and enzymes Molecular processes at the basis of the action of proteins involve the transfer of electrons, protons, hydrogen or hydride atoms, which are coupled to the motion of (charged) molecular groups. Signal transduction proteins convert the event of absorption of a photon in a signal that can be sensed by other proteins. We study these events with ultrafast transient absorption spectroscopy in the visible and mid-infrared spectral regions. Mathematically based analysis of multidimensional data is an important tool in the process of converting experimental data into biophysical knowledge

VU University Amsterdam, Department for Physics and Astronomy Biophysics of Photosynthesis/Energy

Department of Physics and Astronomy VU University - Faculty of Sciences De Boelelaan 1081 Amsterdam, NL-1081 HV NetherlandsThe Biophysics group uses advanced optical spectroscopy and microscopy to obtain fundamental knowledge on the relation between the structure, function and dynamics of proteins and other biological molecules, both in single proteins and in supramolecular aggregates. Photosynthesis Photosynthesis converts energy from light into biological energy and is essential for all life on Earth. For successful operation it requires an integration of (sub-)picosecond photophysical and photochemical processes with developmental and regulatory processes that take place over much longer timescales. Understanding the basic principles that nature exploits in its solar energy converters is of utmost importance to develop new technologies for the production of clean and sustainable energy. We study photosynthesis by a variety of advanced laser-spectroscopic and microscopic techniques, also within the framework of a European Initial Training Network. Photoactive proteins, signal transduction and enzymes Molecular processes at the basis of the action of proteins involve the transfer of electrons, protons, hydrogen or hydride atoms, which are coupled to the motion of (charged) molecular groups. Signal transduction proteins convert the event of absorption of a photon in a signal that can be sensed by other proteins. We study these events with ultrafast transient absorption spectroscopy in the visible and mid-infrared spectral regions. Mathematically based analysis of multidimensional data is an important tool in the process of converting experimental data into biophysical knowledge

VU University Amsterdam Tumor Genome Analysis Core

1117 De Boelelaan Amsterdam, NH, 1081 HV NetherlandsThe Microarray Core Facility (MAF) of the VU University Medical Center/ Cancer Center Amsterdam is involved in a wide spectrum of (inter-) national cancer research and clinical genetics projects.

Wildlife International

Waterstraat 5 7201 HM Zutphen The NetherlandsWildlife International offers analytical chemistry, aquatic and avian toxicology, histopathology, and biodegradation services.

Wageningen Bioveterinary Research

Houtribweg 39Wageningen Bioveterinary Research collaborates with public and private partners to safeguard public and animal health through prevention, eradication and control of animal diseases. Wageningen Bioveterinary Research (WBVR) is part of Wageningen University & Research. We are an independent research institute and as a Contract Research Organization (CRO) we offer effective solutions to issues of public and private clients.

Wacker

Heiligeweg 166 1561 DM Krommenie NetherlandsWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Xendo Drug Development

Bio Science Park, Archimedesweg 17, 2333 CM Leiden, The NetherlandsXendo Drug Development offers bioanalytical, in vitro drug metabolism, pharmacokinetic, and pharmacodynamic services.

Xendo Drug Development

Bio Science Park, ABC building, Niels Bohrweg 11-13, 2333 CA Leiden, The NetherlandsXendo Drug Development offers bioanalytical, in vitro drug metabolism, pharmacokinetic, and pharmacodynamic services.

Yale Pharmaceutical Research Institute

Rotterdam, The NetherlandsYale Pharmaceutical Research Institute offers drug discovery and design, combinatorial chemistry, organic synthesis, ADME testing, pharmacological models, and toxicity services.

ZoBio BV

Postbus 9502 Leiden 2300RA The NetherlandsZoBio is offering an integrated fragment-based drug discovery engine based on orthogonal technologies and 16 years of experience. Located in the Netherlands, ZoBio delivers the right small molecule for your target by combining its expertise in protein sciences, biophysical and biochemical assays, structural biology and medicinal chemistry.

ZoBio BV

J.H. Oortweg Leiden, ZH, 2333 CH NetherlandsZoBio is offering an integrated fragment-based drug discovery engine based on orthogonal technologies and 16 years of experience. Located in the Netherlands, ZoBio delivers the right small molecule for your target by combining its expertise in protein sciences, biophysical and biochemical assays, structural biology and medicinal chemistry.

Aptalis

Amsterdam, The NetherlandsAptalis provides controlled drug release, dosage form, bioavailability enhancement, and drug targeting.

AkzoNobel Polymer Chemicals

Akzo Nobel Polymer Chemicals B.V. Stationsstraat 77 3811 MH Amersfoort P.O. Box 247 3800 AE Amersfoort The NetherlandsAkzo Nobel Polymer Chemicals offers custom synthesis, manufacturing, and APIs.

Axon Medchem

Postbus 770 Groningen, 9700 AT The NetherlandsAxon Medchem offers custom synthesis, organic analysis, and medicinal chemistry services.

Asinex

H.J.E. Wenckebachweg 6V15 MYPUP ARZTH ECHGCB Amsterdam, NH, 1096AN NetherlandsAsinex provides chemical library design, compound resupply, along with hit expansion and lead optimization services.

Abbexa Ltd.

Leiden Bio Science Park Mendelweg 32 Leiden, 2333 CS NetherlandsAbbexa is based at the World renowned Cambridge Science Park, in Cambridge, UK. We are a supplier and distributor of biological tools for the life science, pharmaceutical development and biotechnology sectors. We provide the scientific community with primary antibodies, secondary antibodies, proteins, ELISA kits and enzymes as well as other kits and tools for use in research. Working with various laboratories across the World, we aim to develop relevant, high quality, tested products for the biomedical research market. Abbexa is a dedicated worldwide antibody supplier and protein supplier. Whether you are carrying out academic research, pharmaceutical research, disease research or other biological research, our monoclonal antibodies, polyclonal antibodies, proteins and biological reagents are designed to facilitate your research. We appreciate that sometimes it is hard to find the right antibody to match your needs, and we therefore offer a custom protein, peptide and antibody production pipeline. Abbexa is committed to providing scientists and researchers with the best customer experience and high quality products. We want to provide you with the best support available, which is why we guarantee customer satisfaction. If you are unhappy with the performance of your product we will offer you an immediate replacement or refund. Please have a look at our quality guarantee for further details. We are constantly striving to improve in everything we do, so please do get in touch with any comments regarding the website, service, products, or anything else.

A-ware Food Group

3e Industrieweg 5c 3411 MD Lopik The NetherlandsWe are a family business that specializes inthe maturation, cutting, wrapping, storage, transportation, and sale of cheese and other foodproductsin climate-controlled conditions. Our ambition is to become the most valued chain partner in the European food and agriculturesector, but we are also constantly extending our horizons beyond Europe. Core objective and core values A-ware Food Group is a family business with a passion for cheese. We aim to provide our customers with optimal serviceby offering custom-made solutions. In other words, the best possible – A-quality – service. Our smart and pro-active approach to business means that you can count on usfor an excellent price-quality ratio. The customer is central in everything we do. Applying our flexible approach, wejoin forces with the customer to find tailor-made solutions that deliver optimal results. At the same time, we are constantly improving our service and working on innovations to keep a step ahead of the customer’s needs and market trends. That way, we can continue to guarantee that our customers get the very best services. We invest in the well-being and development of our personnel. Enthusiastic and skilledworkers are a key contributory factor to our high-quality services.

Albert Einstein College of Medicine YU In Vivo Imaging System Core

Ullman 1005The IVIS facility provides access to the the Caliper Life Sciences IVIS Spectrum in vivo imaging system that enables longitudinal three dimensional intravital imaging of animals or tissue expressing bioluminescent (e.g. Firefly luciferase) or far red fluorescent probes. Einstein investigators have used the system to follow tumor growth, tumor metastasis and progression of infectious diseases. The facility is housed within BSL2 animal space. Please note that investigators planning to use the facility for imaging of whole animals must have their experimental protocol approved by the Animal Institute prior to any experiments being conducted. Services In vivo imaging of small animals Bioluminescence imaging (luciferase) of whole animals Far red fluorescence imaging of whole animals

ABL

w.a. scholtenstraat 7 PO Box 232 Assen, 9400 AE The NetherlandsABL (Analytisch Biochemisch Laboratorium) supports clinical trials and pre-clinical drug development studies through its bioanalytical and clinical services.

ABL

Assen, DR NetherlandsABL (Analytisch Biochemisch Laboratorium) supports clinical trials and pre-clinical drug development studies through its bioanalytical and clinical services.

Avantium Technologies

Zekeringstraat 29 1014 BV Amsterdam Amsterdam 1014 NetherlandAvantium specializes in crystallization and solid state pharmaceutical chemistry of small molecules.

Avantium Technologies

Amsterdam, NH NetherlandsAvantium specializes in crystallization and solid state pharmaceutical chemistry of small molecules.

Aegisto

Holland

Acatris

6 Röntgenweg Bunschoten-Spakenburg, UT, 3752 LJ NetherlandsAcatris has an excellent reputation as a supplier to the food processing industry. Acatris ingredients, services and solutions contribute to the production of high quality food, often extending well beyond the repacking of the end product. Acatris offers its customers a wide range of single ingredients (including its Acsoli® product line) and Pectacon® stabiliser systems. Besides thousands of single ingredients and blends, we can also offer an extensive package of processing services, including blending, delumping, grinding, repacking and sieving of raw materials.

AcroMetrix

Jan Steenstraat 1 1816 CT Alkmaar The NetherlandsAcroMetrix offers immunoassays, bloodscreening, dilution, and matrix production.

A4 Lifesciences

Admiraal Trompstraat 8 4702VA, Roosendaal NederlandOur vision is to “deliver affinity ligands based on either DNA, peptides or mixed mode to your targets in less than a week”. We intend to establish a great impact on development speed in therapeutics, diagnostis and separation of biomolecules creating biomarkers in a couple of days. A4 has started an internal program for making custom purfication “resins”. However the company will support anyone in the field of separations with product and business development. We believe that creating strong networks will increase our value to customers and accelerate the realization of our vision. Jacques Clemens B.Sc., owner of A4 combines practical experiences in R&D (immunology) and international sales+management of bio-separation solutions. He worked as sales director for Amersham Pharmacia Biotech (GE Healthcare) and Pall Lifesciences and as vice president for Asahi Kasei Bioprocess selling chromatography, filtration and virus removal applications plus engineering solutions for the same. Most of these projects were highly customised, differing significantly for each client. Jacques founded A4 in 2013 to explore the potential of aptamers replacing antibodies and has built a solid network to deliver affinity products for various purposes.

A4 Lifesciences

8 Admiraal Trompstraat Roosendaal, NB, 4702 VA NetherlandsOur vision is to “deliver affinity ligands based on either DNA, peptides or mixed mode to your targets in less than a week”. We intend to establish a great impact on development speed in therapeutics, diagnostis and separation of biomolecules creating biomarkers in a couple of days. A4 has started an internal program for making custom purfication “resins”. However the company will support anyone in the field of separations with product and business development. We believe that creating strong networks will increase our value to customers and accelerate the realization of our vision. Jacques Clemens B.Sc., owner of A4 combines practical experiences in R&D (immunology) and international sales+management of bio-separation solutions. He worked as sales director for Amersham Pharmacia Biotech (GE Healthcare) and Pall Lifesciences and as vice president for Asahi Kasei Bioprocess selling chromatography, filtration and virus removal applications plus engineering solutions for the same. Most of these projects were highly customised, differing significantly for each client. Jacques founded A4 in 2013 to explore the potential of aptamers replacing antibodies and has built a solid network to deliver affinity products for various purposes.

Abundnz

Trasmolenlaan 5 Woerden, UT, 3447GZ NetherlandsImmundnz, together with its sister company Abundnz, offers advanced in vitro, immunology and (bio)analytical support for biotechnology and diagnostics industries and life sciences research worldwide. A range of solutions are available to our clients. Our services include preclinical immunology research, in vitro research and the characterization and bioanalysis of innovative medicines such as peptide and protein drugs, oligonucleotides and nanomedicines. Due to our experience and track record, you can rely on us as your solid partner in in vitro, immunology and (bio)analytical support for your projects.

Atlant Innov

Koornmarkt, 52 Delft, Zuid-Holland, 2611 EH NetherlandsWe are performing biocatalysis reactions in order to produce a wide variety of chemicals from bulk to pharmaceutical industries. Our uniqueness is based on the use of enzyme and especially perxoygenases and photodecarboxylases.

AkzoNobel Functional Chemicals

Akzo Nobel Head Office Strawinskylaan 2555 1077 ZZ Amsterdam NetherlandsAkzoNobel Functional Chemicals offers chemical intermediates, performance chemicals and end-use consumer products.

AkzoNobel Functional Chemicals

Amsterdam, NH NetherlandsAkzoNobel Functional Chemicals offers chemical intermediates, performance chemicals and end-use consumer products.

Aurion

Binnenhaven 5 Wageningen, PD 6709 The NetherlandsAurion offers custom labeling and supplies immunogold reagents.

Aurion

Wageningen, GE NetherlandsAurion offers custom labeling and supplies immunogold reagents.

Agro Research International B.V.

5 Koeleweg Oldebroek, GE, 8096 RL NetherlandsAgro Research International B.V. is a contract research organization located in the Netherlands. The main areas of expertise and services include trials with agrochemicals, biological products, fertilizers and nutrients. Trials are performed on major field crops, in- and outdoor vegetable crops, ornamental crops and trees and shrubs. Agro Research International B.V. is GEP (Good Experimental Practice) and GLP (Good Laboratory Practice) certified. Field trial studies for registration, demonstration and research & development are conducted via strict quality standards and on a fully confidential basis.

ACE Pharmaceuticals

P.O. BOX 1262 NL-3890 BB Zeewolde The NetherlandsACE Pharmaceuticals offers medical need products and the manufacturing, packaging and supply of clinical trial material.

Ardena

W.A. Scholtenstraat 7 Assen, Drenthe, 9403 AJ NetherlandsArdena is your reliable partner to navigate your small molecule through drug development into the clinic. We make, analyse and file your investigational drug. We offer an integrated services platform to reduce the timeline from initial idea to first-in-human (FIH) clinical verification. We reduce the risk, time and cost to bring your drug to the clinics and market. Take advantage of phase appropriate development and dedicated project management. GMP manufacturing services for clinical trials Phase 1 and Phase 3 clinical trials Drug substance and drug product development ICH stability studies Clinical packaging / labeling / supply services Bio-analytical services

Ardena

Kloosterstraat 9 Oss, Noord-Brabant, 5349 AB NetherlandsArdena is your reliable partner to navigate your small molecule through drug development into the clinic. We make, analyse and file your investigational drug. We offer an integrated services platform to reduce the timeline from initial idea to first-in-human (FIH) clinical verification. We reduce the risk, time and cost to bring your drug to the clinics and market. Take advantage of phase appropriate development and dedicated project management. GMP manufacturing services for clinical trials Phase 1 and Phase 3 clinical trials Drug substance and drug product development ICH stability studies Clinical packaging / labeling / supply services Bio-analytical services

Ardena

W.A. Scholtenstraat 7 Assen, Noord-Holland, 9403 AJ NetherlandsArdena is your reliable partner to navigate your small molecule through drug development into the clinic. We make, analyse and file your investigational drug. We offer an integrated services platform to reduce the timeline from initial idea to first-in-human (FIH) clinical verification. We reduce the risk, time and cost to bring your drug to the clinics and market. Take advantage of phase appropriate development and dedicated project management. GMP manufacturing services for clinical trials Phase 1 and Phase 3 clinical trials Drug substance and drug product development ICH stability studies Clinical packaging / labeling / supply services Bio-analytical services

Ardena

Meibergdreef 31 Amsterdam, Noord-Holland, 1105 AZ NetherlandsArdena is your reliable partner to navigate your small molecule through drug development into the clinic. We make, analyse and file your investigational drug. We offer an integrated services platform to reduce the timeline from initial idea to first-in-human (FIH) clinical verification. We reduce the risk, time and cost to bring your drug to the clinics and market. Take advantage of phase appropriate development and dedicated project management. GMP manufacturing services for clinical trials Phase 1 and Phase 3 clinical trials Drug substance and drug product development ICH stability studies Clinical packaging / labeling / supply services Bio-analytical services

Ardena

Meibergdreef 31 Amsterdam, Noord-Holland, 1105 AZ NetherlandsArdena is your reliable partner to navigate your small molecule through drug development into the clinic. We make, analyse and file your investigational drug. We offer an integrated services platform to reduce the timeline from initial idea to first-in-human (FIH) clinical verification. We reduce the risk, time and cost to bring your drug to the clinics and market. Take advantage of phase appropriate development and dedicated project management. GMP manufacturing services for clinical trials Phase 1 and Phase 3 clinical trials Drug substance and drug product development ICH stability studies Clinical packaging / labeling / supply services Bio-analytical services

Asc Academics

Prof. Enno Dirk Wiersmastraat 5 Groningen, 9713GH NetherlandsAsc Academics is a global market access and health economics consultancy that combines academic rigour, business insights, and creativity to uncover the economic and societal value of healthcare innovations. We provide comprehensive health economic and outcomes research (HEOR) services and strategic market access expertise across a range of therapeutic areas and indications for stakeholders in the private and public sectors.

Asc Academics

Prof. Enno Dirk Wiersmastraat 5 Groningen, 9713GH NetherlandsAsc Academics is a global market access and health economics consultancy that combines academic rigour, business insights, and creativity to uncover the economic and societal value of healthcare innovations. We provide comprehensive health economic and outcomes research (HEOR) services and strategic market access expertise across a range of therapeutic areas and indications for stakeholders in the private and public sectors.

Annogen

Science Park 406 Amsterdam, 1098XH NetherlandsWe perform functional genome annotation on an unprecedented scale using our unique SuRE technology. Our screening services enable the identification of regulatory DNA elements as well as the mutations in these elements that define traits and diseases in humans, plants and animals. The SuRE method is in essence a strategy to analyze millions of DNA elements for their activity as promoters or enhancers in a single experiment. By analyzing ~300 million DNA elements of ~300bp length, an entire human genome can be analyzed exhaustively at an approximate 30 fold coverage. The only required input is DNA and once a SuRE library is established it can analyzed and compared to other DNA sources in the controlled environment of any transfectable cell type. Thus, without the requirement of invasive biopsies, any genome of interest can be analyzed in relevant cell types and under relevant (e.g. stimulatory) conditions. For further reading please see this publication: https://rdcu.be/bH2xl. Recently we (through Gen-X BV) closed an exclusive deal with uniQure for the gene therapy field underpinning the interest and added value of our platform. With the newly incorporated spin out company Annogen we commercialize our proprietary technology outside the gene therapy field focusing on cell therapy and other applications. A short overview: SuRE™ technology - Functional Annotation of the Non-coding Genome: Identification of 1. regulatory DNA elements 2. mutations in these elements that define traits and diseases in humans, plants and animals. Applied for 1. cell therapy (cell and tissue specific -inducible- regulatory elements) 2. drug discovery (>95% of disease-protective and –causative variants lie in regulatory DNA) 3. patient-drug response (identifying non-coding variants to predict differential drug responses)

BioClinica

Schipholweg 117 2316 XC Leiden The NetherlandsBioClinica offers imaging services.

Biomedical Primate Research Center (BPRC)

161 Lange Kleiweg Rijswijk, ZH, 2288 GJ NetherlandsDisease causes misery and large numbers of deaths in human populations worldwide. For many common deadly diseases there is still a desperate need for effective medicines. BPRC is a scientific research institute that exists to perform vital research that contributes to the identification and development of these new medicines. BPRC is committed to using non-human primates for this critical research only where there are no suitable alternatives. Research is also required to identify and develop alternatives to the use of non-human primates. BPRC has an active and expanding programme to develop alternatives following the principles of reduction, refinement and replacement Corporal social responsibility (CSR) has a high priority at BPRC. The BPRC is e.g. certified for responsible environmental policy (ISO 14001/2004) and is international recognized for animal welfare policy (AAALAC).

Bioceros

Remco M. Brandt / Yalelaan 46 / 3584 CM Utrecht / The NetherlandsBioceros provides generation of cell lines, transfection of CHO cells, preclinical manufacturing, characterization of products, and in vivo studies.

BioDetection Systems

Science Park 406 1098 XH Amsterdam The Netherlands

Biorizon

Green Chemistry Campus Plasticslaan 1 - Port 1 4612 PX Bergen op Zoom The NetherlandsBiorizon is a Shared Research Center with an initial focus on technology development for the production of functionalized biobased aromatics for performance materials, chemicals & coatings. Biorizon is anticipating the expected growing shortage of aromatics from the petrochemical industry and the widely shared ambition to green the chemical industry. Our goal is to be a leading European Center for functionalized biobased aromatics within 3 years and to be in the global top 3 within 5 years. This way the participating companies will get the best results possible!

BioXpert BV

Landerd Campus Nistelrooise Baan 35374 RE SchaijkThe NetherlandsWe at BioXpert are experts in laboratory animal science and services to in vivo research in the life sciences. We are specialised in listening to your demands and translating them into a tailor made solution for you. We offer a wide range of services, so that we can help you with any aspect in your in vivo research. We can do this in in our own lab and animal facilities or on site.

BioXpert BV

Nistelrooise Baan 3, Schaijk, 5374 RE NetherlandsWe at BioXpert are experts in laboratory animal science and services to in vivo research in the life sciences. We are specialised in listening to your demands and translating them into a tailor made solution for you. We offer a wide range of services, so that we can help you with any aspect in your in vivo research. We can do this in in our own lab and animal facilities or on site.

BAC

Huizerstraatweg 28 1411 GP Naarden The NetherlandsBAC discovers, develops and manufactures affinity ligands and affinity purification products.

BaseClear

Galileiweg 4 Leiden, Leiden, 2333 BD NetherlandsGENOMICS EXPERTISE AND CONSULTANCY TO ACCELERATE THE UNDERSTANDING AND USE OF MICROORGANISMS Microbiome analysis: Genomics expertise and consultancy to support your industrial microbiome application Regulatory affairs: Consultancy for genomics-based characterisation as required for EFSA or FDA claims Microbiological Quality Control: Rapid testing services for microbiological quality control laboratories

BaseClear

Sylviusweg 74 Leiden, Leiden, 2333CC NetherlandsGENOMICS EXPERTISE AND CONSULTANCY TO ACCELERATE THE UNDERSTANDING AND USE OF MICROORGANISMS Microbiome analysis: Genomics expertise and consultancy to support your industrial microbiome application Regulatory affairs: Consultancy for genomics-based characterisation as required for EFSA or FDA claims Microbiological Quality Control: Rapid testing services for microbiological quality control laboratories

BIRD Engineering

Westfrankelandsedijk 1 3115 HG Schiedam NetherlandsBIRD Engineering offers strain development, fermentation technology and sample production.

Biolegio

Biolegio B.V. Lagelandseweg 56 6545 CG Nijmegen The NetherlandsBiolegio offers custom Oligonucleotide synthesis services. Founded in 1996, DNA synthesis has been at the core of our business for more than 20 years. Our product offering includes standard DNA & RNA Oligos through to highly specialised Oligos incorporating any commercially available modification. We specialise in the provision of long Oligos and our unrivalled coupling efficiency during long synthesis enables us to offer high quality longmer Oligos with an appreciable yield of full length material up to 300 bases in length. With satisfied customers throughout the world our Oligos are used daily in a diverse range of applications including DNA sequencing, NGS, PCR, qPCR, target enrichment, SNP detection, synthetic biology, gene expression, gene silencing and more. Our manufacturing facility is ISO 9001:2008 and ISO 13485:2003 certified, ensuring high quality, reliable and safe products as a result of strong product quality and manufacturing procedures and an ongoing development of our quality management system. As a small business we pride ourselves on our service and customer satisfaction, for example with our dispensing & packaging service you can have your Oligos delivered in any format, quantity, concentration or combination.

Biolegio

Biolegio B.V. Lagelandseweg 56 Nijmegen, 6545 CG NetherlandsBiolegio offers custom Oligonucleotide synthesis services. Founded in 1996, DNA synthesis has been at the core of our business for more than 20 years. Our product offering includes standard DNA & RNA Oligos through to highly specialised Oligos incorporating any commercially available modification. We specialise in the provision of long Oligos and our unrivalled coupling efficiency during long synthesis enables us to offer high quality longmer Oligos with an appreciable yield of full length material up to 300 bases in length. With satisfied customers throughout the world our Oligos are used daily in a diverse range of applications including DNA sequencing, NGS, PCR, qPCR, target enrichment, SNP detection, synthetic biology, gene expression, gene silencing and more. Our manufacturing facility is ISO 9001:2008 and ISO 13485:2003 certified, ensuring high quality, reliable and safe products as a result of strong product quality and manufacturing procedures and an ongoing development of our quality management system. As a small business we pride ourselves on our service and customer satisfaction, for example with our dispensing & packaging service you can have your Oligos delivered in any format, quantity, concentration or combination.

Bio-Prodict BV

Robert Boyleweg 4 Leiden, Zuid-Holland, 2311TA Netherlands

Bio-Prodict BV

54e Nieuwe Marktstraat Nijmegen, GE, 6511 AA Netherlands

Biomedical Primate Research Centre - duplicate

Postbox 3306 Rijswijk, 2280 GH The NetherlandsBiomedical Primate Research Centre focuses on research and offers primate models for the testing of therapeutics for malaria, tuberculosis, hepatitis C, HIV/AIDS, and automimmune diseases.

Biomedical Primate Research Centre - duplicate

Rijswijk, ZH NetherlandsBiomedical Primate Research Centre focuses on research and offers primate models for the testing of therapeutics for malaria, tuberculosis, hepatitis C, HIV/AIDS, and automimmune diseases.

BioVisible

L.J.Zielstraweg 1 Groningen, 9713 GX The NetherlandsBioVisible offers a unique analysis service for the evaluation of the effects of probiotics and prebiotics on Gut microflora using FISH (fluorescence in situ hybridization), (T)DGGE ((Temperature)Denaturing Gradient Gel Electrophoresis) and/or Real-time PCR.

Batavia Biosciences

Bioscience Park Leiden Zernikedreef 9 Leiden, CK 2333 The NetherlandsBatavia Biosciences is a contract development organization for biopharmaceuticals and vaccines with end to end solutions for customers. The mission is to significantly contribute to ease human suffering from disease by improving the success rate in the translation of candidate medicines from discovery to the clinic. Hereto, the company has developed a portfolio of technologies aimed to improve product yield (STEP®, SCOPE®), reduce process development time (SIDUS®, SCOUT®) and increase product stability (SATIRN®). These technologies have amply demonstrated to improve speed and reduce cost in biopharmaceutical development, accelerating the journey from bench to clinic. Batavia Biosciences performs projects for big pharma, biotech, academia and non-profit organizations. The company employs a highly educated staff with many years of experience in DNA cloning, mammalian cell line generation, upstream and downstream process development (mammalian, microbial & insect cell platforms), purification development, product characterization, and clinical manufacturing. As such the company, with laboratories in USA and the Netherlands, is well positioned to take on any challenge associated with the development of complex biological medicines be it proteins, antibodies, vaccines or viral vectors.

Batavia Biosciences

Zernikedreef 16 Leiden, 2333 CL NetherlandsBatavia Biosciences is a contract development organization for biopharmaceuticals and vaccines with end to end solutions for customers. The mission is to significantly contribute to ease human suffering from disease by improving the success rate in the translation of candidate medicines from discovery to the clinic. Hereto, the company has developed a portfolio of technologies aimed to improve product yield (STEP®, SCOPE®), reduce process development time (SIDUS®, SCOUT®) and increase product stability (SATIRN®). These technologies have amply demonstrated to improve speed and reduce cost in biopharmaceutical development, accelerating the journey from bench to clinic. Batavia Biosciences performs projects for big pharma, biotech, academia and non-profit organizations. The company employs a highly educated staff with many years of experience in DNA cloning, mammalian cell line generation, upstream and downstream process development (mammalian, microbial & insect cell platforms), purification development, product characterization, and clinical manufacturing. As such the company, with laboratories in USA and the Netherlands, is well positioned to take on any challenge associated with the development of complex biological medicines be it proteins, antibodies, vaccines or viral vectors.

Chiesi farmaceutici

Lange Kleiweg 52 J - 2288 GK Rijswijk - the NetherlandsChiesi farmaceutici offers drug development, drug discovery, and clinical trials.

Core Laboratories

Amsterdam, The Netherlands

Cambridge Major Laboratories

NK Weert, The NetherlandsCambridge Major Laboratories provides custom synthesis, GMP manufacturing, analytical method development, ICH stability studies, and route scouting.

Clondalkin Group

Ito Tower, 9th Floor, Gustav Mahlerplein 68, 1082 MA Amsterdam, The Netherlands

CENTRE FOR HUMAN DRUG RESEARCH

Centre for Human Drug Research Zernikedreef 8 2333 CL Leiden The NetherlandsCentre for Human Drug Research provides a full spectrum of early stage clinical pharmacology services.

CENTRE FOR HUMAN DRUG RESEARCH

8 Zernikedreef Leiden, ZH, 2333 CL NetherlandsCentre for Human Drug Research provides a full spectrum of early stage clinical pharmacology services.

Cogent Communications

Benelux, Ukraine, CIS Countries Halfweg, NH, 1165 MK NetherlandsCogent expedites the secure transfer of large data files between domestic and global locations including the U.S., U.K., Europe, Japan, China, Korea, Singapore, Australia, and Brazil. [NASDAQ: CCOI] Cogent is a Tier 1 Global Internet Service Provider with the most interconnected network in the world – connecting to 6700 networks and 1200 Data Centers in over 200 markets spanning 45 countries. Approximately 21% of the world’s Internet traffic travels our network daily. Our core product offerings include Dedicated Internet Access, Ethernet Point-to-Point, Ethernet VPLS, SDWAN, and Colocation services offered over our award-winning fiber optic, IP data-only network.

Cell Signaling Technology

Einsteinweg 5 N Leiden, 2333CC NetherlandsFounded by research scientists in 1999, Cell Signaling Technology (CST) is a family-owned company focused on applied systems biology research, and especially cancer. We believe you have the right to expect more reliable results from your antibodies and reagents so our scientists produce, validate and support all our antibodies in-house. Cell Signaling Technology is able to provide target validation services, biomarker discovery services, phospho-specific antibody design services and patient stratification services.

Cell Signaling Technology

Dellaertweg 9b 2316 WZ Leiden, 2316 NetherlandsFounded by research scientists in 1999, Cell Signaling Technology (CST) is a family-owned company focused on applied systems biology research, and especially cancer. We believe you have the right to expect more reliable results from your antibodies and reagents so our scientists produce, validate and support all our antibodies in-house. Cell Signaling Technology is able to provide target validation services, biomarker discovery services, phospho-specific antibody design services and patient stratification services.

Charles River Laboratories

Darwinweg 24 Leiden, Nederlands, 2333CR NetherlandsCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Chantest, WIL, MPI, KWS Biotest, Brains On-line, CiTox LAB, Solvo Biotechnology, Distributed Bio, Cognate Bioservices, Cobra Biologics, ViGene, and Retrogenix. To learn more about our unique portfolio and breadth of services, visit www.criver.com, www.solvo.com, www.cognatebioservices.com, www.cobrabio.com and www.retrogenix.com

Charles River Laboratories

Darwinweg 24 Leiden, 2333CR NetherlandsCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Chantest, WIL, MPI, KWS Biotest, Brains On-line, CiTox LAB, Solvo Biotechnology, Distributed Bio, Cognate Bioservices, Cobra Biologics, ViGene, and Retrogenix. To learn more about our unique portfolio and breadth of services, visit www.criver.com, www.solvo.com, www.cognatebioservices.com, www.cobrabio.com and www.retrogenix.com

Charles River Laboratories

De Mudden 16 Groningen, 9747 AW NetherlandsCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Chantest, WIL, MPI, KWS Biotest, Brains On-line, CiTox LAB, Solvo Biotechnology, Distributed Bio, Cognate Bioservices, Cobra Biologics, ViGene, and Retrogenix. To learn more about our unique portfolio and breadth of services, visit www.criver.com, www.solvo.com, www.cognatebioservices.com, www.cobrabio.com and www.retrogenix.com

Charles River Laboratories

Hambakenwetering 7 Hertogenbosch, 5231 DD's NetherlandsCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Chantest, WIL, MPI, KWS Biotest, Brains On-line, CiTox LAB, Solvo Biotechnology, Distributed Bio, Cognate Bioservices, Cobra Biologics, ViGene, and Retrogenix. To learn more about our unique portfolio and breadth of services, visit www.criver.com, www.solvo.com, www.cognatebioservices.com, www.cobrabio.com and www.retrogenix.com

CERGENTIS BV

62 Yalelaan Utrecht, UT, 3584 NetherlandsCergentis is a genomics-focused biotechnology company that developed the patented Targeted Locus Amplification (TLA) technology, a widely published Next Generation Sequencing (NGS)-based enrichment strategy. Thanks to its unique resolution and unmatched capabilities, TLA offers unique advantages in the quality control of advanced genetic engineering. Our TLA-based genetic solutions can be applied to determine: • All sequence changes resulting from targeted genome editing. • All vector integration sites. • Structural changes in the host genome surrounding vector integration sites. • Single nucleotide variants in a vector sequence. • Structural changes in a vector sequence. • Co-integration of backbone or contaminating E.coli sequences Cergentis has established itself as the go-to partner for the characterization of genetically engineered cell lines, cell and gene therapy products and animal models for the global biopharmaceutical industry and leading research institutes. We develop and sell services and in-house solutions for targeted and complete sequencing of (trans)genes and gene editing events and provide services for the support in R&D in these fields. Our expertise lies in the analysis of (complex) genetic engineering projects in various organisms and sample types, including CHO, human cell lines (T cells, HEK293, HeLa, etc.) and transgenic animals (mice, rats, goats, pigs, etc.). TLA data is widely used in the selection and characterization of genetically engineered cell lines and animals and has been widely used in support of >70 peer-reviewed publications. TLA obsoletes the use of southern blot and FISH, yielding NGS-based data at a fraction of the turnaround time and costs. Moreover, Cergentis studies are performed and reported to be acceptable for regulatory filings in accordance with FDA and EMA requirements (CTD module 3.2.S.2.3.) and have been used in both early (IND) and late stage (BLA) dossiers. It is our mission to improve the quality of genetic research: supporting biopharmaceutical R&D will accelerate the development of new treatments with better outcomes for patients all over the world.

CERGENTIS BV

Yalelaan 62 Utrecht, 3584 CM NetherlandsCergentis is a genomics-focused biotechnology company that developed the patented Targeted Locus Amplification (TLA) technology, a widely published Next Generation Sequencing (NGS)-based enrichment strategy. Thanks to its unique resolution and unmatched capabilities, TLA offers unique advantages in the quality control of advanced genetic engineering. Our TLA-based genetic solutions can be applied to determine: • All sequence changes resulting from targeted genome editing. • All vector integration sites. • Structural changes in the host genome surrounding vector integration sites. • Single nucleotide variants in a vector sequence. • Structural changes in a vector sequence. • Co-integration of backbone or contaminating E.coli sequences Cergentis has established itself as the go-to partner for the characterization of genetically engineered cell lines, cell and gene therapy products and animal models for the global biopharmaceutical industry and leading research institutes. We develop and sell services and in-house solutions for targeted and complete sequencing of (trans)genes and gene editing events and provide services for the support in R&D in these fields. Our expertise lies in the analysis of (complex) genetic engineering projects in various organisms and sample types, including CHO, human cell lines (T cells, HEK293, HeLa, etc.) and transgenic animals (mice, rats, goats, pigs, etc.). TLA data is widely used in the selection and characterization of genetically engineered cell lines and animals and has been widely used in support of >70 peer-reviewed publications. TLA obsoletes the use of southern blot and FISH, yielding NGS-based data at a fraction of the turnaround time and costs. Moreover, Cergentis studies are performed and reported to be acceptable for regulatory filings in accordance with FDA and EMA requirements (CTD module 3.2.S.2.3.) and have been used in both early (IND) and late stage (BLA) dossiers. It is our mission to improve the quality of genetic research: supporting biopharmaceutical R&D will accelerate the development of new treatments with better outcomes for patients all over the world.

Corning Life Sciences

12 Fogostraat Fogostraat 12 Amsterdam, NH, 1060 LJ NetherlandsCorning Life Sciences offers a variety of in vitro ADME Gentest® branded products and contract research services covering drug metabolism and drug interactions. These products and services support Enzyme Induction, Enzyme Inhibition, Metabolic Stability, Reaction Phenotyping, Protein Binding, Permeability and Drug Transport and other applications.

Corning Life Sciences

Fogostraat 12 Amsterdam, 1060 LJ Netherlands c/o Corning Switzerland GmbH D4 Platz 10 Root, 6039 SwitzerlandCorning Life Sciences offers a variety of in vitro ADME Gentest® branded products and contract research services covering drug metabolism and drug interactions. These products and services support Enzyme Induction, Enzyme Inhibition, Metabolic Stability, Reaction Phenotyping, Protein Binding, Permeability and Drug Transport and other applications.

Corning Life Sciences

Corning Life Sciences BV: Ute Vespermann 12 Fogostraat, Fogostraat 12 Amsterdam, NH, 1060 LJ Netherlands Corning Switzerland GmbH D4 Platz 10 Root, 6039 SwitzerlandCorning Life Sciences offers a variety of in vitro ADME Gentest® branded products and contract research services covering drug metabolism and drug interactions. These products and services support Enzyme Induction, Enzyme Inhibition, Metabolic Stability, Reaction Phenotyping, Protein Binding, Permeability and Drug Transport and other applications.

CARDIOLABORATE

Moreelsepark 1, 3511 EP Utrecht NetherlandsCARDIOLABORATE is an inter-academic science broker that stimulates public-private collaborations in the field of cardiovascular biomarkers in the Netherlands. CARDIOLABORATE has the ambition to build new public-private collaborations in the field of cardiovascular biomarkers by revealing a portfolio of facilities and unique opportunities in (pre)-clinical research that will accelerate biomarker discovery and assay development and validation, and generates more revenues for the Dutch players in this arena.

Cardialysis

Westblaak 92, entrance B, 3012 KM Rotterdam The NetherlandsCardialysis offers cardiovascular imaging and clinical trial services.

Crown Bioscience, Inc.

Yalelaan 42 Utrecht, 3584 CM NetherlandsCrown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) providing discovery, preclinical and translational platforms to advance oncology, immuno-oncology, and immune-mediated inflammatory diseases. Known for their high quality and expansive in vivo, in vitro and ex vivo preclinical models, they partner with their clients to quantify the efficacy and pharmacological profile of their drug candidate before they move into the clinic. The company is the only preclinical CRO to provide tumor organoid services utilizing HUB technology and has the world’s largest commercially available PDX collection. Additionally, further services available in the areas of high content imaging and a 3D Ex Vivo Patient Tissue Platform, provide greater insights into complex disease pathophysiology. A range of biomarker analysis and applied genomics services are also available to optimize therapeutic benefit. Crown Bioscience helps to deliver superior drug candidates to ensure that patients get the right treatment at the right time. Founded in 2006, Crown Bioscience has nine facilities in the US, Europe, and Asia. Find out more: www.crownbio.com

Crown Bioscience, Inc.

J.H. Oortweg 21 Leiden, 2333 CH NetherlandsCrown Bioscience, a JSR Life Sciences company, is a global contract research organization (CRO) providing discovery, preclinical and translational platforms to advance oncology, immuno-oncology, and immune-mediated inflammatory diseases. Known for their high quality and expansive in vivo, in vitro and ex vivo preclinical models, they partner with their clients to quantify the efficacy and pharmacological profile of their drug candidate before they move into the clinic. The company is the only preclinical CRO to provide tumor organoid services utilizing HUB technology and has the world’s largest commercially available PDX collection. Additionally, further services available in the areas of high content imaging and a 3D Ex Vivo Patient Tissue Platform, provide greater insights into complex disease pathophysiology. A range of biomarker analysis and applied genomics services are also available to optimize therapeutic benefit. Crown Bioscience helps to deliver superior drug candidates to ensure that patients get the right treatment at the right time. Founded in 2006, Crown Bioscience has nine facilities in the US, Europe, and Asia. Find out more: www.crownbio.com

Chiralix

Toernooiveld 100 Nijmegen, 6525 EC The NetherlandsChiralix specializes in chiral organic synthesis, chiral drug-like building blocks, and custom synthesis services.