3915 Research Park Drive, Ste A1 Ann Arbor, MI, 48108 United StatesAAPharmaSyn provides medicinal chemistry, process development, SAR, lead optimization and custom organic synthesis services. Are specialties are communication and problem solving. We encourage you to contact us to discuss your chemistry needs.

3985 Research Park Drive Ann Arbor MI 48108AAPharmaSyn provides medicinal chemistry, process development, SAR, lead optimization and custom organic synthesis services. Are specialties are communication and problem solving. We encourage you to contact us to discuss your chemistry needs.

3985 Research Park Dr Ann Arbor, MI, 48108 United StatesAAPharmaSyn provides medicinal chemistry, process development, SAR, lead optimization and custom organic synthesis services. Are specialties are communication and problem solving. We encourage you to contact us to discuss your chemistry needs.

4079 Ramsgate Court Ann Arbor, MI, 48103 United StatesFounded by Lon Grantham and Kjell Johnson, two director-level statisticians previously employed at a large pharmaceutical company, Arbor Analytics, LLC has 40 years of combined professional statistical consulting experience.

339 E Liberty St #210 Ann Arbor , Michigan , 48104 United StatesArborMetrix has deep expertise in both the design and implementation of longitudinal RWE studies executed through clinical data registries for various research, quality improvement, and post-market surveillance initiatives. InsightX, ArborMetrix’s data science platform, allows for efficient aggregation and deep analysis of healthcare data and deploys advanced analytics that deliver credible, trusted insights that lead to results that have a real impact on real people.

179 W. Randall Street, Suite A Coopersville, MI 49404AlliAnce Analytical a full service microbiology and chemical analysis testing laboratory serving the water, food, beverage, forage, cosmetic, automotive and furniture industries. We partner as the technical extension and support of your company, assisting you in achieving your quality standards.

6841 North Rochester Road Suite 100 Rochester Hills, MI 48306BRS provides ISO 17025 accredited microbiological testing services. As well as our routine testing, we also offer microbiological research, special project testing and consulting services. The laboratory was founded in 1986. A privately owned company, the active owner, John W. Wireman, Ph.D., has over 44 years experience in microbiology and the industry.

2105 Pless Dr Brighton, MI 48114-9463 USABrighton Analytical offers environmental and microbiological testing services.

Brighton, MI, 48116 United StatesBrighton Analytical offers environmental and microbiological testing services.

440 Burroughs Street Detroit, MI, 48202 United StatesBioIVT, formerly BioreclamationIVT, is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. And as the world’s premier supplier of ADME-toxicology model systems, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in ELEVATING SCIENCE. For more information about our processes on the regulatory oversight of Human Biological Specimens (HBS), please visit our website, www.bioivt.com, for more information. Specific information related to our quality and ethical assurances can be found here: https://www.bioivt.com/about/quality-assurance/.

UNKNOWNBASF Competence Center Analytics offers chromatography, elemental analysis, spectroscopy, and physicochemical analysis services.

Novi, MI, USABoroPharm specializes in custom synthesis and manufacture of boron containing compounds.

Novi, MI United StatesBoroPharm specializes in custom synthesis and manufacture of boron containing compounds.

528 West Center Dr Portage MI 49024 USABioStat Solutions offers biostatistics, genotyping, gene expression, and pharmacogenomic services.

175 College Street Battle Creek, MI, 49037 United States

1950 Tobsal Court, Warren, MI 48091-1351Biosan Laboratories is an environmental microbiology laboratory that was founded by Dr. Harold Rossmoore in 1973. Our initial microbiology lab was in Ferndale, MI where we remained until 1994. Since we knew many of our lab customers would benefit from the ability to perform microbiology testing on-site, Biosan developed the following bacteria and fungi test kits: the Sani-Check AB for detecting bacteria, the Sani-Check YM for detecting fungi, the Sani-Check SRB kit for detecting anaerobic sulfate reducing bacteria. Microbiological Test Kit Manufacturing Facility In response to our clients’ needs, we developed an agar based detection method known as a dipslide for microbiological testing. In 1994, we moved to a 6400 square foot building in Warren, Michigan and added a 3600 square foot manufacturing area in order to expand our manufacturing capacity. Today our production department is dedicated to making high quality agar dipslides for the microbial testing of a variety of industrial fluids.

Vicksburg, MI, USABridge Organics provides custom synthesis of small molecules, metabolites, analytical impurities, isotope-labeled chemicals and compound libraries.

311 W. Washington Street United States Vicksburg, Mi, 49097 United StatesBridge Organics provides custom synthesis of small molecules, metabolites, analytical impurities, isotope-labeled chemicals and compound libraries.

Portage, MI, USABioSTAT Consultants offers customized statistical services and consultation.

Portage, MI United StatesBioSTAT Consultants offers customized statistical services and consultation.

23169 Michigan Avenue Suite #23101 Dearborn, MI 48124 USABennettBIO offers tissue procurement services.

Kelvinstraat 41bBioIntron focusses on recombinant protein & antibody services, in particular recombinant antibodies. This includes bi-specific and other antibody variants. Next to this we offer scale up expression, antibody humanization, human naïve library, single domain Ab (Alpaca), stable cell line development, catalog proteins and antibodies and OEM reagents for IVD / IHC.

Michigan Life Science & Innovation Corridor 46701 Commerce Center Dr Plymouth MI 48170BioSavita has developed platform yeast (S.cerevisiae) expression platform for accelerated development of antibody fusion proteins, antibodies, difficult to express proteins in other systems and VLP vaccines

BioSavita, Inc. 46701 Commerce Center Dr Plymouth, MI 48170BioSavita has developed platform yeast (S.cerevisiae) expression platform for accelerated development of antibody fusion proteins, antibodies, difficult to express proteins in other systems and VLP vaccines

BioSavita, Inc. 46701 Commerce Center Dr Plymouth, MI 48170BioSavita has developed platform yeast (S.cerevisiae) expression platform for accelerated development of antibody fusion proteins, antibodies, difficult to express proteins in other systems and VLP vaccines

Plymouth, MI, 48170 United StatesBioSavita has developed platform yeast (S.cerevisiae) expression platform for accelerated development of antibody fusion proteins, antibodies, difficult to express proteins in other systems and VLP vaccines

1872 N. Adams Road Rochester Hills, MI 48306 USACell Culture Characterization Service offers cell line identification and characterization by isoenzyme analysis, cytogenetic analysis, and fluorescent in situ hybridization.

1180 East Ellsworth Road Ann Arbor, MI 48108 USACayman Biomedical Research Institute (CaBRI) is a non-profit, tax-exempt organization focused on the study and therapy of rare genetic defects and cancers.

International Partnership for Critical Markers of Disease Suite H1200, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106International Partnership for Critical Markers of Disease (CMOD) organizes symposia and scientists to advance cardiovascular research.

44461 Phoenix Drive Sterling Heights, MI 48314CSZ Testing offers stability testing and accelerated aging services.

Kalamazoo, MI, USACeeTox offers in vitro toxicity screening, HTS, and in vitro assays.

1180 East Ellsworth Road Ann Arbor, Michigan, 48108 United StatesCayman Contract Services provides discovery and preclinical development services to the global pharmaceutical, biotechnology, and academic research markets. Our diverse suite of services leverages a team of over 150 highly skilled scientists with expertise in medicinal chemistry, structure-based drug design (SBDD), in silico/computer-aided drug design (CADD), complex multi-step organic synthesis, analytical chemistry, sample analysis, and custom assay development. We offer a personalized, flexible approach that enables our clients to accelerate their drug discovery and development through a single-source partner, from novel drug design and synthesis to target identification and validation. FOR CATALOG OR BULK CATALOG ORDERS, PLEASE VISIT OUR WEBSITE www.caymanchem.com OR CONTACT sales@caymanchem.com

54943 N. Main Street Mattawan, Michigan, 49071 United StatesCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Recently Charles River acquired Chantest, WIL, MPI, KWS Biotest, Brains On-line, CiTox LAB, Solvo Biotechnology, Distributed Bio, Cognate Bioservices, Cobra Biologics, ViGene, Retrogenix, and SAMDI Tech. To learn more about our unique portfolio and breadth of services, visit www.criver.com, www.solvo.com, www.cognatebioservices.com, www.cobrabio.com, www.retrogenix.com, and www.samditech.com.

UNKNOWNClintegral provides phase II-IV studies in India.

1200 S Franklin St, Mt Pleasant, MI 48859​​​​​​​​​Welcome to Central Michigan University, a nurturing institution that fosters the transformative power of advanced learning. From our roots as a teachers’ college, CMU has grown to offer nationally acclaimed programs in areas ranging from the health professions and engineering to business and communications. Our student and faculty researchers help preserve the earth’s resources, discover new ways to treat diseases, advance innovative ways to improve teaching and learning methods, and much more. Established in 1892, Central Michigan University is among the nation’s 100 largest public universities with more than 20,000 students on its Mount Pleasant campus and another 7,000 enrolled online and at more than 4​0 locations across North America. CMU offers more than 200 academic programs at the undergraduate, master’s, specialist and doctoral levels.

11942 Sara Ann Dr. Dewitt, MI 48820 USACrystallographic Resources offers crystallization services and single crystal X-ray diffraction services.

11942 Sara Ann Drive DeWitt, Michigan, 48820 United StatesCrystallographic Resources offers crystallization services and single crystal X-ray diffraction services.

Big Rapids, MI, 49307 United StatesFor 20 years, we were D. Anderson & Company—a pioneer in patient recruitment and retention for global clinical trials

3100 Walkent Drive NW Grand Rapids, MI 49544For 20 years, we were D. Anderson & Company—a pioneer in patient recruitment and retention for global clinical trials

2245 S. State Street Suite 1100 Ann Arbor, MI 48104Decision Informatics consults life science organizations in decision making, leadership, medicinal chemistry, and software.

P.O. Box 1206 Midland MI 48642 USADow Chemical offers analytical services, clinical trials, manufacturing, cell services, chemistry, and drug services.

334 East Washington Street, Ann Arbor, MI 48104DNA Software provides molecular biology software, structural biology prediction software, software consulting, and nucleic acid services.

0050 CARL BuildingThe Functional Genomics Shared Resource was established as a shared resource for the application of functional genomic technologies to support the research programs of investigators at Duke and beyond. Through investments in genetic and chemical perturbation technologies, we have assembled state-of-the-art reagents and equipment, providing researchers access to genome-wide RNAi reagents and the infrastructure necessary to conduct large-scale functional studies in mammalian cells. Expertise: The facility serves to provide expertise in the development and use of reagents for genetic perturbation, including RNAi, ORF overexpression and CRISPR-CAS9 gene editing platforms. Genetic Reagents: We maintain several human genome RNAi collections for screening: The Qiagen Human genome siRNA library v1.0, the TRC1 lentiviral shRNA library and an MSCV-based retroviral shRNA library. The siRNA library may be screened in arrayed format, subsets of the TRC1 library may be screened in arrayed or pooled format and the MSCV retroviral library is available only in pooled format. We also distribute individual lentiviral shRNA clones from the TRC are available as bacterial glycerol stocks, through our shRNA request system. Chemical Reagents: We have several libraries available for screening, see http://sites.duke.edu/functionalgenomics/screening/ for more details. Genome-wide screens: The Functional Genomics Shared Resource has developed the infrastructure necessary to conduct high-throughput screens, providing automated liquid handlers, cell platers and plate washers. For plate-based quantitative assays, we have the Cellomics high-content screening system, as well as multimodal plate readers. Screens can also be performed in pooled format using a selection-based strategy. Phenotypic assays: The facility offers high-content screening with the Cellomics ArrayScan system, as well as sensitive signal detection with two high-performance multimodal plate readers. All systems are equipped with plate stackers and barcode readers for walk-away functionality and true high-throughput processing.

50 Carl Houghton Lake, MI, 48630 United StatesThe Functional Genomics Shared Resource was established as a shared resource for the application of functional genomic technologies to support the research programs of investigators at Duke and beyond. Through investments in genetic and chemical perturbation technologies, we have assembled state-of-the-art reagents and equipment, providing researchers access to genome-wide RNAi reagents and the infrastructure necessary to conduct large-scale functional studies in mammalian cells. Expertise: The facility serves to provide expertise in the development and use of reagents for genetic perturbation, including RNAi, ORF overexpression and CRISPR-CAS9 gene editing platforms. Genetic Reagents: We maintain several human genome RNAi collections for screening: The Qiagen Human genome siRNA library v1.0, the TRC1 lentiviral shRNA library and an MSCV-based retroviral shRNA library. The siRNA library may be screened in arrayed format, subsets of the TRC1 library may be screened in arrayed or pooled format and the MSCV retroviral library is available only in pooled format. We also distribute individual lentiviral shRNA clones from the TRC are available as bacterial glycerol stocks, through our shRNA request system. Chemical Reagents: We have several libraries available for screening, see http://sites.duke.edu/functionalgenomics/screening/ for more details. Genome-wide screens: The Functional Genomics Shared Resource has developed the infrastructure necessary to conduct high-throughput screens, providing automated liquid handlers, cell platers and plate washers. For plate-based quantitative assays, we have the Cellomics high-content screening system, as well as multimodal plate readers. Screens can also be performed in pooled format using a selection-based strategy. Phenotypic assays: The facility offers high-content screening with the Cellomics ArrayScan system, as well as sensitive signal detection with two high-performance multimodal plate readers. All systems are equipped with plate stackers and barcode readers for walk-away functionality and true high-throughput processing.

2601 Coolidge Rd, Suite 203 East Lansing, MI 48823-6361All laboratories are accredited by the American Association of Blood Banks (AABB). Our home kit testing is identical to the testing of a formal legal test. We are members of many professional trade organizations and have never received a customer complaint (this can be verified). Our website has been thoroughly scrutinized by one of the largest and well known "truth in advertising" trade organizations. We must substantiate every questionable claim made on this website. IMPORTANT - Non reliable and deceptive companies cannot join trade organizations which require truth in advertising. Avoid companies with negative advertising. We offer complete and secure ordering capability online. Low price guarantee. We offer a 100% home test reimbursement if you need a formal court admissible test (see details). We are the only company that makes this offer. Fast, guaranteed same day shipping. All U.S. orders come with a prepaid mailer to return your samples to the lab. We offer more ordering options and shipping capability than the majority of DNA testing companies. All orders are confidential, billed and shipped by D-FWmall.com (no indication of DNA testing). We have been selling home DNA tests on the internet longer than anyone. This is a substantiated claim. Friendly customer service. All calls are immediately answered or returned promptly during normal business hours. A representative is available evenings and weekends to return emergency calls. Fast turnaround time once the lab receives your samples. No waiting 3-6 weeks to complete your results.

32 University Drive East Lansing, MI 48823 USAexeResearch specializes in computational chemistry and biochemistry and offers methods/protocol development, ligand-based design, protein modeling, and structure-based design services.

Essen BioScience, Inc. 300 West Morgan Road Ann Arbor, Michigan 48108 USAEssen Bioscience provides ion channel discovery, cardiac safety, and live-cell kinetic assays.

3985 RESEARCH PARK DR ANN ARBOR, MI, 48108 United StatesEversight restores sight and prevents blindness through donation, transplantation and research. The eye bank network provides 8,000+ surgical grafts for transplant and 3,000+ ocular tissues for eye and vision research annually. Eversight research experts procure, process, preserve and distribute human ocular tissue with medical records to meet specific research needs. The Eversight Center for Vision and Eye Banking Research in Cleveland offers in-house R&D services that enable Eversight to serve as a CRO, conducting projects for external partners. Capabilities include ex-vivo drug testing; specular microscopy, light and fluorescence microscopy; slit lamp and OCT imaging; histology; tissue dissection; and RNA/DNA/protein isolation and quantification. Operating in Connecticut, Illinois, Michigan, New Jersey, Ohio and South Korea, Eversight works with surgeons, researchers, academic medical centers and eye banks worldwide

Enzo Life Sciences Inc. – Ann Arbor (formerly Assay Designs Inc.) 5777 Hines Drive Ann Arbor, MI 48108 USAEnzo Life Sciences, Inc. is a recognized leader in labeling and detection technologies across research and diagnostic markets. Our strong portfolio of proteins, antibodies, peptides, small molecules, labeling probes dyes and kits provides life science researchers tools for target identification/validation, high content analysis, gene expression analysis, nucleic acid detection, protein biochemistry and detection, and cellular analysis.

173 Parkland Plaza SUITE C Ann Arbor, MI, 48103 United StatesEyeCRO offers in vivo and eyedrop formulation ophthalmic contract research services.

900 Oakwood St, Ypsilanti, MI 48197Mission : EMU enriches lives in a supportive, intellectually dynamic and diverse community. Our dedicated faculty balance teaching and research to prepare students with relevant skills and real world awareness. We are an institution of opportunity where students learn in and beyond the classroom to benefit the local and global communities. Vision : Eastern Michigan University will be a premier public university recognized for student-centered learning, high quality academic programs and community impact.

3500 N. Martin Luther King Jr. Blvd. Lansing, MI 48906Emergent is dedicated to one simple mission—to protect and enhance life. As a global specialty pharmaceutical company, Emergent offers specialized products to healthcare providers and governments to address medical needs and emerging health threats. Our goal We pursue innovative ways to protect life. Whether it is developing and delivering specialized products that can make life better for millions of adults and children or medical countermeasures that protect the nation against chemical and biological threats, we are passionate in pursuit of our mission—to protect and enhance 50 million lives by 2025. We give highest priority to:​ • Delivering on our commitments to patients, customers and partners • Pursuing innovation in our product portfolio • Developing our employees • Giving back to our communities • Achieving our financial goals

168 Wealthy St. S.W Grand Rapids, MI 49503 USAFormax Manufacturing Corporation offers buffing wheels, polishing compounds, abrasive products and glues in application of lab equipment and other tools.

Grand Rapids, MI United StatesFormax Manufacturing Corporation offers buffing wheels, polishing compounds, abrasive products and glues in application of lab equipment and other tools.

44792 Helm Street Plymouth, MI, 48170 United StatesThe Fraunhofer USA Center for Molecular Biotechnology (FhCMB) is a unique institution conducting translational research in the area of pharmaceutical biotechnology, utilizing cutting-edge technologies to advance products for prevention, diagnosis and treatment of infectious diseases and autoimmune disorders. FhCMB, located in Newark, Delaware, is a division of Fraunhofer USA, Inc, a not-for-profit research organization. FhCMB has assembled a dedicated and expert work force of over ninety full-time employees with extensive experience in research and development, GMP manufacturing, QA/QC, regulatory/clinical affairs and technology transfer. Lead scientists at the Center have published widely on recombinant protein production and are inventors on key enabling patents. FhCMB is located in Newark, Delaware and occupies a 56,000 square foot building containing state-of-the-art laboratories, plant-growth facilities and a 12,000 square foot cGMP pilot production facility with the capacity to make gram quantities of protein products.

1201 S. State Street, Big Rapids, Michigan, USA 49307Some Ferris majors are offered at no other university in Michigan or the United States. More than 180 undergraduate and graduate majors include 2-year degrees that "ladder" into 4-year, Bachelor of Science and Bachelor of Arts degrees, eight master's degrees and Doctorates of Education, Optometry and Pharmacy.

1201 S. State Street Big Rapids, Michigan, 49307 United StatesSome Ferris majors are offered at no other university in Michigan or the United States. More than 180 undergraduate and graduate majors include 2-year degrees that "ladder" into 4-year, Bachelor of Science and Bachelor of Arts degrees, eight master's degrees and Doctorates of Education, Optometry and Pharmacy.

440 Burroughs Street Suite 641 Ann Arbor, MICHIGAN, 48202 United StatesFunctional Fluidics has developed a suite of proprietary flow based assays that measure adhesion & thrombosis in whole blood. We enable our pharmaceutical and academic partners to predict, select, and monitor a variety of emerging and established blood function therapies. We specialize in the development and standardization of clinical blood function assays to assess individual patient response to our partners’ therapies.

3569 Preserve Dr Dexter MI 48130-8402 USAGeneVivo offers custom tailored transgenic animals.

206 South 5th Avenue Ann Arbor, MI, 48104 United StatesOur technology leverages the gene expression of special cells, called cumulus cells. These cells are essential for successful oocyte development, but regularly discarded during the IVF process.

46701 COMMERCE CENTER DRIVE PLYMOUTH, MI, 48170 United StatesGreat Lakes Biologics is a Contract Research Development Organization (CRDO) specializing in the process development of small-scale batches of biologic product candidates used in biopharmaceutical research and development under service contracts. Our Mission is to develop a robust platform capable of rapid process development for vaccines and other biologics in a cost-effective manner. Proprietary yeast strains developed by synthetic biology, protein engineering, and process development are the three key components of GLB’s innovative and unique capabilities for successful execution of contract projects. Our team has a combined experience of well over 100 years in the private and public biotechnology and pharmaceutical industry.

1 Campus Dr. Allendale, Michigan 49401KHS Microscopy Facility Kindschi Hall of Science offers a wide variety of microscopy needs.

1 Campus Drive Allendale Charter Township, MI, 49401 United StatesKHS Microscopy Facility Kindschi Hall of Science offers a wide variety of microscopy needs.

4949 Delemere Ave. Royal Oak, MI 48073 USAGIC Thermodynamics manufactures and offers custom temperature sensors.

Royal Oak, MI United StatesGIC Thermodynamics manufactures and offers custom temperature sensors.

1 Campus Dr. Allendale, Michigan 49401

Ann Arbor, Michigan, USAGLP Quality Consulting provides GLP quality assurance services for the pharmaceutical, biotech and agricultural chemical industries.

1 Campus Dr. Allendale, Michigan 49401Aquarium

St. Joseph, MI, USAGeneGo offers toxicology, analysis of OMICs datasets, genomics, and compound profiling.

2847 Lawrence Stevensville, MI, 49127 United StatesGreat Lakes Scientific is a private, independent testing laboratory offering microbiological, chemical, and nutritional analyses for food and water. We have been offering testing services to food manufacturers and processors since 1983. We are located in Stevensville, Michigan 65 miles east of Chicago in Southwest Lower Michigan.

140 Front Ave SW Suite 3 Grand Rapids, MI 49504Grand River Aseptic Pharmaceutical Packaging offers lyophilization, cold storage, aseptic filling, and manufacturing services.

Eberhard Center 104 301 W. Fulton Grand Rapids, MI 49504Welcome to Psychology at GVSU. Students major in psychology for various reasons, and different sets of courses are likely to be appropriate for students with different goals. Students should plan their studies in consultation with an academic advisor early and throughout their college career. Psychology covers such a broad range of topics that psychologists specialize in many different areas, such as clinical psychology, counseling psychology, developmental psychology, physiological psychology, neuropsychology, industrial-organizational psychology, educational psychology, experimental psychology, cognitive psychology, social psychology, and cross-cultural psychology. The interests and training of the faculty members in the department cover all of these areas, so we are able to offer a wide range of courses in the undergraduate curriculum.

4717 Campus Drive Suite 1800 Kalamazoo, MI 49008 USAGenemarkers is contract research organization that specializes in genomics. Genemarkers provides gene expression and genotyping services for pharmaceutical, biotechnology and personal care companies. Studies are used to support all phases of molecular research, from biomarker discovery to the development of a molecular diagnostic test. Under the auspices of its CLIA lab, the company provides PGX (pharmacogenomics) and genetic testing - enabling physicians with information to guide personalized treatments. PGX testing is used to identify which drugs will work best for an individual patient, reducing trial and error and adverse drug responses. The company is a certified woman owned company (WBENC) and has been recognized as one of the Top 50 Companies to Watch in 2013. Dr. Anna Langerveld, PhD, President and CEO was a semi-finalist in the Edward Lowe Entrepreneur of the Year Award in 2013.

126 E South St Kalamazoo, MI, 49007 United StatesGenemarkers is contract research organization that specializes in genomics. Genemarkers provides gene expression and genotyping services for pharmaceutical, biotechnology and personal care companies. Studies are used to support all phases of molecular research, from biomarker discovery to the development of a molecular diagnostic test. Under the auspices of its CLIA lab, the company provides PGX (pharmacogenomics) and genetic testing - enabling physicians with information to guide personalized treatments. PGX testing is used to identify which drugs will work best for an individual patient, reducing trial and error and adverse drug responses. The company is a certified woman owned company (WBENC) and has been recognized as one of the Top 50 Companies to Watch in 2013. Dr. Anna Langerveld, PhD, President and CEO was a semi-finalist in the Edward Lowe Entrepreneur of the Year Award in 2013.

Lake Michigan Center 740 W. Shoreline Dr. Muskegon, Michigan 49441The Robert B. Annis Water Resources Institute (AWRI) is a multidisciplinary research organization within GVSU's College of Liberal Arts and Sciences (CLAS). AWRI's mission is to integrate research, education, and outreach to enhance and preserve freshwater resources.

775 Technology Drive Suite 100A Ann Arbor, MI 48108 USAGene Codes Corporation offers their proprietary software, Sequencher, to support DNA sequence data analysis.

Ann Arbor, MI United StatesGene Codes Corporation offers their proprietary software, Sequencher, to support DNA sequence data analysis.

4917 Dawn Avenue East Lansing, MI 48823-5691 USAHuntsman is a global manufacturer and marketer of differentiated chemicals. Our operating companies manufacture products for a variety of global industries, including chemicals, plastics, automotive, aviation, textiles, footwear, paints and coatings, construction, technology, agriculture, health care, detergent, personal care, furniture, appliances and packaging. Originally known for pioneering innovations in packaging and, later, for rapid and integrated growth in petrochemicals, Huntsman has approximately 15,000 employees and operates from multiple locations worldwide. The Company had 2015 revenues of over $10 billion.

28044 James Dr. Warren, MI 48092 USAHelix Biological Laboratory offers molecular biology, microbiology, and protein analysis services.

Warren, MI United StatesHelix Biological Laboratory offers molecular biology, microbiology, and protein analysis services.

6088 Main & Mill Streets St Miamiville, OH 45147 USAHill Top Research provides safety testing, efficacy testing, microbiology, and clinical services.

421 Ann Street Northwest Grand Rapids, MI, 49504 United StatesHaviland Products offers commodity chemistry, surface finishing, specialty chemistry, and contract manufacturing services.

PO Box 9000, Holland, Michigan 49422-9000Hope College is a four-year liberal arts college where academic excellence and vibrant Christian faith join together in a supportive and welcoming community. Hope’s campus is nestled in the heart of downtown Holland, just miles from Lake Michigan. We’ve been part of this community for more than 150 years, growing from the 10 students who enrolled in 1862 to more than 3,300 students on campus today. From the beginning, Hope College has looked to the future. Here, historic architecture fits comfortably with world-class facilities: Van Vleck Hall, built in 1857, is just a block from our Pelletron particle accelerator. Our commitment to our Christian heritage (founded in partnership with the Reformed Church in America) points us to the deepest engagement in academics and in life.

310 N. Main Street, Suite 301 Chelsea, MI 48118 USAInternational Discovery Services & Consulting (IDSC) offers pharmacokinetics, pharmacodynamics, toxicokinetics, medicinal chemistry, molecular modeling and in vivo/in vitro research model development.

2833 Alex Drive Ann Arbor MI 48103Integrated Nonclinical Devel. Solns offers toxicology, biotherapeutics, natural products, process improvement, formulations, and study monitoring.

4717 Campus Drive Kalamazoo, MI 49008IONTOX is a health sciences company formed to provide expertise in the area of in vitro toxicology with a mission to build improved methods for predicting human adverse effects from chemical exposure. The company’s innovation greatly enhances current in vitro testing techniques and will dramatically reduce the use of animals for new molecular entity testing.

4717 Campus Drive United States Kalamazoo, MI, 49008 United StatesIONTOX is a health sciences company formed to provide expertise in the area of in vitro toxicology with a mission to build improved methods for predicting human adverse effects from chemical exposure. The company’s innovation greatly enhances current in vitro testing techniques and will dramatically reduce the use of animals for new molecular entity testing.

46430 Peary Court Novi, MI, 48377 United StatesInnovative Research supplies human and animal biologicals, coagulation proteins, antibodies and ELISA kits.

1940 North Stark Road Midland, MI, 48642 United StatesImpact Analytical is a contract testing laboratory supporting all phases of drug development and manufacturing, consumer products, and medical device testing. We offer method development, validation, stability, extractables & leachables, problem solving, unknown identification, release testing, competitive analysis, failure analysis, raw material testing, surfactant analysis, and many other services. We have 30+ years of polymer and chemistry analysis experience. Impact Analytical is a GMP registered, GLP compliant (FDA, EPA), ISO 9001 certified, and DEA licensed. We are routinely audited by the FDA with no findings (483’s). Our customer-focused approach differentiates us in the industry and ensures you receive high quality results that are on-time and on-budget. Please contact us to schedule a facility audit and discuss your next project.

526 Jasper St. Kalamazoo, MI 49007 USAJasper Clinic offers clinical pharmacology services to support medical device, diagnostics, and phase I-IV studies.

2245 South State Street Suite 1100 Ann Arbor, MI 48104 USAJV Biolabs provides the development and utilization of human cell and organ culture, and pre-clinical models.

1456 Glastonbury Rd Ann Arbor, MI, 48103 United StatesJV Biolabs provides the development and utilization of human cell and organ culture, and pre-clinical models.

4646 John R Street Detroit, MI, 48201 United StatesSince 1939, the Detroit VA Healthcare System has been improving the health of the men and women who have so proudly served our nation. In 1996, the medical center moved from its original location in Allen Park, Michigan to the current location in Detroit. Located in the Midtown area of Detroit, it’s our privilege to serve your health care needs in any way we can. Services are available to more than 330,000 Veterans living in Wayne, Oakland, Macomb and St. Clair counties. This population represents approximately forty-four percent of the Veteran population in the lower peninsula of Michigan.

5051 Piehl Road, Ottawa Lake, MI 49267 USAJog A Dog is a manufacturer and distributor of high end treadmills for exercising dogs.

1825 Bailey Ave. Dearborn, Michigan 48124-2488Krasity's Medical & Surgical Supply is a distributor for medical and surgical supplies and equipment.

Dearborn, MI United StatesKrasity's Medical & Surgical Supply is a distributor for medical and surgical supplies and equipment.

4425 Manchester Road Kalamazoo MI 49001 USAKAR Bioanalytical provides kinetic studies, toxicology, method validation, and spectrometry.

P.O. Box 50511 Kalamazoo, MI 49005-0511Our products, derived from natural herbs, spices, vegetables and hops, are translated into easy-to-use liquids ideal for most formulations. These are of the highest quality and consistency available. Kalsec® is the only company whose expertise and resources encompass a full line of natural, innovative products and solutions to meet the challenges faced by food and beverage manufacturers throughout the industry and around the world.

4502 Campus Drive Kalamazoo, MI, 49008 United StatesKalexsyn offers custom synthesis and medicinal chemistry services, stable label synthesis, and process improvement services.

4425 Manchester Road Kalamazoo, MI 49001 USAKAR Laboratories provides analytical services and assists clients in interpretation of data.

Kelly Corporate Headquarters 999 West Big Beaver Road Troy, Michigan (USA) 48084-4782Kelly founded the temporary staffing industry in 1946, and has maintained a leadership position through the years based on a valuable premise: we invest in people.

Troy, MI United StatesKelly founded the temporary staffing industry in 1946, and has maintained a leadership position through the years based on a valuable premise: we invest in people.

3F, Kobe MI R&D Center, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047,JapanKAN Research Institute conducts research with academic research organizations.

1200 Academy Street Kalamazoo Michigan 49006-3295 USAThe mission of Kalamazoo College is to prepare its graduates to better understand, live successfully within, and provide enlightened leadership to a richly diverse and increasingly complex world. Welcome to Kalamazoo College. President Jorge G. Gonzalez President Jorge G. Gonzalez Together in a fellowship in learning, the members of the Kalamazoo College community are developing a model of an educated citizen that combines scholarship, civic engagement, and in-depth living experiences in other countries. As a highly selective, nationally renowned, and internationally oriented four-year college of arts and sciences, Kalamazoo College has developed a tradition of excellence in the fulfillment of this mission. It is located in Kalamazoo, Michigan. Founded in 1833, Kalamazoo College is among the 100 oldest colleges and universities in the nation.

1200 Academy Street Kalamazoo, MI, 49006 United StatesThe mission of Kalamazoo College is to prepare its graduates to better understand, live successfully within, and provide enlightened leadership to a richly diverse and increasingly complex world. Welcome to Kalamazoo College. President Jorge G. Gonzalez President Jorge G. Gonzalez Together in a fellowship in learning, the members of the Kalamazoo College community are developing a model of an educated citizen that combines scholarship, civic engagement, and in-depth living experiences in other countries. As a highly selective, nationally renowned, and internationally oriented four-year college of arts and sciences, Kalamazoo College has developed a tradition of excellence in the fulfillment of this mission. It is located in Kalamazoo, Michigan. Founded in 1833, Kalamazoo College is among the 100 oldest colleges and universities in the nation.

24469 Indoplex Circle Farmington Hills, MI, USA, 48335-2527Labs-Mart focuses on the quick and cost-effective delivery of analyses. Keeping your time constraints in mind, we have developed an exceptional turn-around time to meet your testing needs in a punctual manner. At Labs-Mart, we are proud to offer customer convenience with our comprehensive testing services. Our wide range of analytical testing includes nutraceuticals, herbals, enzymes, microbials, metals, pesticides, dioxins, PCBs, solvent residues, and mycotoxins. We also provide services for full nutritional panels and food analysis. Our facility is Health Canada GMPlicensed and employs state-of-the-art equipment and the most up-to-date testing methodologies in accordance with Health Canada andUSFDA regulations. We are service-oriented professionals whose only business is your testing needs.

24469 Indoplex Circle Farmington Hills, MI, 48335-2527 United StatesLabs-Mart focuses on the quick and cost-effective delivery of analyses. Keeping your time constraints in mind, we have developed an exceptional turn-around time to meet your testing needs in a punctual manner. At Labs-Mart, we are proud to offer customer convenience with our comprehensive testing services. Our wide range of analytical testing includes nutraceuticals, herbals, enzymes, microbials, metals, pesticides, dioxins, PCBs, solvent residues, and mycotoxins. We also provide services for full nutritional panels and food analysis. Our facility is Health Canada GMPlicensed and employs state-of-the-art equipment and the most up-to-date testing methodologies in accordance with Health Canada andUSFDA regulations. We are service-oriented professionals whose only business is your testing needs.

46701 Commerce Center Dr Plymouth, MI, 48170 United StatesLife Magnetics, Inc. has developed a unique nucleic acid separation method with National Science Foundation support. The company is leveraging our deep expertise in life science tools to solve problems, support innovation, and help clients with their molecular work.

2968 Barclay Way Ann Arbor, MI, 48105 United StatesProvide scientific consulting services. My aim is to help others do good science by helping to design and analyze experiments, providing (or helping to find) voice of customer input on product development, editing technical documents or helping to introduce new technologies to your arsenal of tools. I am an experienced molecular and cellular biologist with expertise in product and assay development.

3256 Iron St Burton, MI 48529Landaal Packaging Systems has over 50 years combined experience in contract packaging, and will help you develop the most cost-effective packaging solutions for your specific product. In addition to supplying the necessary high skilled labor and automation to perform the packaging function, we can also source any of the other packaging materials required for your job and manage your entire project, from start to finish.

1400 Townsend Drive Houghton, MI 49931-1295Michigan Technological University is a leading public research university, home to 7,238 students from more than 50 countries around the world. Founded in 1885, the University offers more than 120 undergraduate and graduate degree programs in science, technology, engineering, and mathematics. Our beautiful campus in Michigan’s Upper Peninsula overlooks the Keweenaw Waterway and is just a few miles from Lake Superior.

1400 Townsend Drive Houghton, , MI , 49931-1295 United StatesMichigan Technological University is a leading public research university, home to 7,238 students from more than 50 countries around the world. Founded in 1885, the University offers more than 120 undergraduate and graduate degree programs in science, technology, engineering, and mathematics. Our beautiful campus in Michigan’s Upper Peninsula overlooks the Keweenaw Waterway and is just a few miles from Lake Superior.

440 Burroughs Street Detroit, MI, 48202 United StatesOur inventory includes four million newborn dried blood samples representing nearly every Michigan birth since mid-1984.

2905 Hilton RoadMAS offers analytical testing services.

Ferndale, MI, 48220 United StatesMAS offers analytical testing services.

Canton, MI United StatesMMS Holdings offers clinical research services such as clinical development, regulatory affairs, and pharmacovigilance.

46430 Peary Court, Novi, MI 48377 USAMolecular Innovations supplies researchers worldwide with high quality scientific research products including purified proteins, antibodies and ELISA kits. Our product lines include PAI-1, Renin, Prorenin, Vitronectin, Fibrinogen, Fibronectin, Plasminogen, Plasmin, Antithrombin, and many other interesting targets.

46430 Peary Ct Novi, MI, 48377 United StatesMolecular Innovations supplies researchers worldwide with high quality scientific research products including purified proteins, antibodies and ELISA kits. Our product lines include PAI-1, Renin, Prorenin, Vitronectin, Fibrinogen, Fibronectin, Plasminogen, Plasmin, Antithrombin, and many other interesting targets.

3950 Varsity Drive Ann Arbor, MI, 48108 United StatesMS Bioworks is a state of the art protein mass spectrometry service provider delivering the highest quality data to Industrial and government organizations as well as academic institutions.

7107 Elm Valley DriveMichigan High Throughput Screening Center provides high quality assay development, high throughput screening, and complete data analysis services.

1100 Baker Road, Dexter, MI, 48130-0160 USAMager Scientific provides metallurgical equipment, EM sample preparation, imaging tools, and consumables.

38521 Schoolcraft Road, Livonia, Michigan 48150 USAMcGean offers specialty chemicals, inorganic intermediates, and manufacturing services.

800 Technology Drive Ann Arbor MI 48108 USAMolecular Imaging provides efficacy testing, validation of imaging technology, model development, immunohistochemistry, and flow cytometry.

Michigan State University Research Technology Support Facility, East Lansing, Michigan 48824Michigan State University Research Technology Support Facility provides proteomics, bioinformatics, flow cytometry, purification, and genomic services.

26105 Orchard Lake Road Suite 210 Farmington Hills MI 48334, USAMeelunie is a global supplier of agricultural ingredients.

4717 Campus Drive Kalamazoo MI 49008Micromyx antibacterial, microbiome, and antifungal R&D Services Micromyx is a microbiology services company located in Kalamazoo, Michigan. We conduct a variety of in vitro assays for pharma, biotech, medical device, and animal health companies that are actively engaged in antibacterial and antifungal R&D, as well as microbiome studies. Assays include drug combination, susceptibility testing, time-kill, resistance development, mechanism of action, beta lactamase assays, phage, and many more. Our capabilities include working with anaerobes and microbiome-related studies. We have our own culture collection of >10,000 clinical pathogens obtained from hospitals. In addition, we have written the microbiology section for many INDs and NDAs. We would like to have the opportunity to discuss our capabilities and how we may be able to assist with your projects.

5840 Interface Drive Suite 101 Ann Arbor, MI, 48103 United StatesMYcroarray is a scientist-owned and operated company focused on the manufacturing of custom oligonucleotides. We are a passionate organization determined to deliver high quality, cost-effective molecular biology tools to the genetics research market. We routinely collaborate with our customers and research partners to develop innovative designs and applications for custom synthetic oligos. We welcome the opportunity to develop a custom solution with our technology to help answer your unique research question.

39555 Orchard Hill Place, Suite 600 Novi, MI 48375 USANopras Technologies is a globally recognized management consulting firm which specializes in services to organizations in the pharmaceutical, biotechnology/biologics, medical device/diagnostics and other FDA regulated industries. Our service portfolio covers FDA and foreign regulations/guidelines and spans the full product development life cycle from clinical development through market scrutiny.

620 Lesher PlaceNeogen develops and manufactures ELISA test kits to support forensic drug detection and research.

1210 Pontaluna Rd, Norton Shores, MI 49456For over twenty years, Northern Biomedical Research has collaborated with clients in the basic science, pharmaceutical and biomedical device communities to provide in vivo support in the development of treatments for diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, epilepsy, CNS oncology, lysosomal storage disorders and spinal muscular atrophy. The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential neuropharmaceuticals, evaluating delivery systems and devices, and testing novel surgical and therapeutic protocols. Techniques used provide unprecedented access to the CNS with minimal anatomical or physiological compromise. The results provide quality, precise and repeatable data on an assured basis, while working within a GLP environment. We look forward to discussing and implementing your research objectives.

1210 Pontaluna Rd SPRING LAKE, MI, 49456 United StatesFor over twenty years, Northern Biomedical Research has collaborated with clients in the basic science, pharmaceutical and biomedical device communities to provide in vivo support in the development of treatments for diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, epilepsy, CNS oncology, lysosomal storage disorders and spinal muscular atrophy. The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential neuropharmaceuticals, evaluating delivery systems and devices, and testing novel surgical and therapeutic protocols. Techniques used provide unprecedented access to the CNS with minimal anatomical or physiological compromise. The results provide quality, precise and repeatable data on an assured basis, while working within a GLP environment. We look forward to discussing and implementing your research objectives.

1971 E Beltline Ave NE #204 Grand Rapids, MI, 49525 United StatesNeurocore offers drug development and research for cell and gene therapeutics including cell based assays, assay development, efficacy model development, feasibility studies, histological analysis, and quality assurance.

789 North Dixboro RoadNSF International is an independent, not-for-profit organization that certifies products and writes standards for food, water and consumer goods

Kalamazoo, MI United StatesNephRx focuses on the discovery and development of therapeutic peptides for acute kidney disease and gastrointestinal disorders.

1401 Presque Isle Ave. • Marquette, MI 49855-5301Northern Michigan University, located in Marquette, Michigan, is a dynamic four-year, public, comprehensive university that has grown its reputation based on its award-winning leadership programs, cutting-edge technology initiatives and nationally recognized academic programs. Northern Michigan has a population of about 9,000 undergraduate and graduate students. It offers 147 degree programs, including 25 graduate programs. The university has two semesters per year, a fall and winter semester, and two summer sessions. NMU is one of three Michigan public universities to also serve a community college role for its region, which means the breadth of NMU’s academic programs range from one-year diplomas through a doctorate. NMU began offering its first doctoral program – the Doctor of Nursing Practice – in fall 2014. NMU’s most popular bachelor’s degrees are art and design, nursing, criminal justice, elementary education and biology. The university’s fastest growing academic areas are clinical science, biology, and the geographical and environmental sciences.

1401 Presque Isle Ave. Marquette, , MI , 49855-5301 United StatesNorthern Michigan University, located in Marquette, Michigan, is a dynamic four-year, public, comprehensive university that has grown its reputation based on its award-winning leadership programs, cutting-edge technology initiatives and nationally recognized academic programs. Northern Michigan has a population of about 9,000 undergraduate and graduate students. It offers 147 degree programs, including 25 graduate programs. The university has two semesters per year, a fall and winter semester, and two summer sessions. NMU is one of three Michigan public universities to also serve a community college role for its region, which means the breadth of NMU’s academic programs range from one-year diplomas through a doctorate. NMU began offering its first doctoral program – the Doctor of Nursing Practice – in fall 2014. NMU’s most popular bachelor’s degrees are art and design, nursing, criminal justice, elementary education and biology. The university’s fastest growing academic areas are clinical science, biology, and the geographical and environmental sciences.

4401 Varsity Drive, Suite E, Ann Arbor, MI 48108 USAProtein biomarker discovery, assay development and qualification services. Tests hundreds of CSF/Plasma proteins simultaneously in each sample. More than 100 samples in a week.

5512 Bob White Avenue Kalamazoo, MI, 49009 United StatesOphthy-DS offers ophthalmic model services for macular degeneration, diabetes, uveitis, and dry eye.

2165 Avon Industrial Dr. Rochester Hills MI 48309 USAOxford Biomedical Research offers assay services, EIAs, assay kits, reagents, toxicoproteomics, and metabolomics.

Wilson Hall 371 Wilson Boulevard Rochester, Michigan 48309-4486Oakland University's $5.8-million Biomedical Research Support Facility has been providing a high quality environment for animal research since it opened in August of 1999. This 7,500-square foot facility was funded, in part, by a grant from the National Center for Research Resources. The state of the art structure features sixteen environmentally controlled animal housing rooms with an on-line computer control and monitoring system, and centralized cage-washing equipment that provides pass-through sterilization. The surgery area contains two operating suites that offer up to six surgical stations and an operating support room, recovery room, diagnostic lab, and radiological capabilities. Also contained in the facility is a barrier/containment BSL-2 suite for work with animals involving infectious agents. These features support advanced biomedical research at Oakland University by providing the proper space and equipment for the humane care and use of laboratory animals in research. The Biomedical Research Support Facility offers centralized laboratory animal research services that adhere to all applicable laws, standards and policies that govern responsible use of animals in research and education. The Biomedical Research Support Facility is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC), a voluntary accrediting organization that enhances the quality of research, teaching, and testing by promoting humane, responsible animal care and use.

Wilson Hall 371 Wilson Boulevard Rochester,, Michigan, 48309-4486 United StatesOakland University's $5.8-million Biomedical Research Support Facility has been providing a high quality environment for animal research since it opened in August of 1999. This 7,500-square foot facility was funded, in part, by a grant from the National Center for Research Resources. The state of the art structure features sixteen environmentally controlled animal housing rooms with an on-line computer control and monitoring system, and centralized cage-washing equipment that provides pass-through sterilization. The surgery area contains two operating suites that offer up to six surgical stations and an operating support room, recovery room, diagnostic lab, and radiological capabilities. Also contained in the facility is a barrier/containment BSL-2 suite for work with animals involving infectious agents. These features support advanced biomedical research at Oakland University by providing the proper space and equipment for the humane care and use of laboratory animals in research. The Biomedical Research Support Facility offers centralized laboratory animal research services that adhere to all applicable laws, standards and policies that govern responsible use of animals in research and education. The Biomedical Research Support Facility is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC), a voluntary accrediting organization that enhances the quality of research, teaching, and testing by promoting humane, responsible animal care and use.

3985 Research Park Drive Suite 200 Ann Arbor MI 48108Originus provides transient transfection and high throughput assays for drug development and functional genomics.

300 Water Street Allegan, Michigan 49010Perrigo develops, manufactures and distributes over-the-counter and prescription pharmaceuticals, nutritional products, active pharmaceutical ingredients and consumer products.

Perrigo Company Corporate Office 515 Eastern Avenue Allegan, Michigan 49010Perrigo develops, manufactures and distributes over-the-counter and prescription pharmaceuticals, nutritional products, active pharmaceutical ingredients and consumer products.

Allegan, MI, 49010 United StatesPerrigo develops, manufactures and distributes over-the-counter and prescription pharmaceuticals, nutritional products, active pharmaceutical ingredients and consumer products.

2059 North Pound DrivePrecision Medical Technologies provides manufacturing support for orthopedic, spinal, and other medical products.

870 Parkdale Road Rochester, MI 48307We develop, manufacture and distribute quality generic pharmaceuticals across a wide range of therapeutic areas. A subsidiary of Par Pharmaceutical company an Endo International company.

4717 Campus Drive Kalamazoo, MI 49008Proteos is a high-quality contract research organization serving the pharmaceutical, biotechnology, and life science communities. Our mission is to deliver high quality research reagents and data. We offer multiple expression platforms that can be combined with purification services for production of high-quality recombinant proteins and antibodies. All of our processes have been thoroughly validated in-house to ensure delivery of high quality product. With decades of combined experience, our highly skilled scientists are ready to get started on your protein or antibody research project. Proteos is an industry leader in customer-driven project design and implementation. First, we work closely with our customers to develop quotations containing a customized detailed workflow so that you will know each step of your project before the work is even initiated. Second, dedicated project managers monitor the project’s progress and communicate important project details to you in a timely manner. Finally, at project completion, along with the delivery of high quality protein, you will receive a complete technical report detailing the entire project workflow with all associated data.

4717 Campus Drive Kalamazoo, MI, 60143 United StatesProteos is a high-quality contract research organization serving the pharmaceutical, biotechnology, and life science communities. Our mission is to deliver high quality research reagents and data. We offer multiple expression platforms that can be combined with purification services for production of high-quality recombinant proteins and antibodies. All of our processes have been thoroughly validated in-house to ensure delivery of high quality product. With decades of combined experience, our highly skilled scientists are ready to get started on your protein or antibody research project. Proteos is an industry leader in customer-driven project design and implementation. First, we work closely with our customers to develop quotations containing a customized detailed workflow so that you will know each step of your project before the work is even initiated. Second, dedicated project managers monitor the project’s progress and communicate important project details to you in a timely manner. Finally, at project completion, along with the delivery of high quality protein, you will receive a complete technical report detailing the entire project workflow with all associated data.

6710 Quality Way Portage, MI 49002 United StatesPharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services. Drug Development Services • full range of pharmacokinetic and ADME services for IND/NDA • vivarium with skilled technical staff • LC-MS/MS method development and validation • FDA Crystal City guidelines • GLP compliant sample analysis Biochemistry Services • cell-based assays • protein expression o prokaryotic (E.coli) o eukaryotic (mammalian, insect cell/baculovirus) • protein purification • ligand binding assays • isothermal denaturation • enzyme inhibitor characterization and mechanism • fluorescence polarization and other fluorescence based assays • biomarker assays • ELISA • MSD electrochemiluminescence Bioanalytical Services • rapid screening methods • method development and validation • FDA Crystal City • OECD • preclinical pharmacokinetics • PK/PD assessment • toxicokinetic investigations of absorption and clearance • bioavailability/bioequivalence • ocular PK • cassette (n-in-1) dosing and analysis • prodrug and metabolite PK Assays and Assay Development • immunosorbent assays • traditional ELISA (HRP, AP) • ECL (Meso Scale Discovery format) technologies • development of multiplex immunoassays using MSD technology • cell-based assays: signal transduction (eg cAMP) • ligand binding assays • radio-isotope • isothermal denaturation • fluorescence intensity and polarization • enzyme assays and kinetics • inhibitor mechanism and validation • MSD Certification • Human Aβ42 • Human Total Tau Ophthalmic Research Services • pharmacokinetics/ADME • pharmacology and biochemistry • specialized dosing • specialized tissue and fluid collection • precise sample processing and bioanalysis • biomarker assays • MSD electrochemiluminescence • standard ELISA Ocular Efficacy Models • VEGF induced retinal vascular leakage (wet AMD) • blue light damage (dry AMD) • STZ induced diabetic retinopathy • laser induced CNV • LPS induced Uveitis • allergic response

6710 Quality Way Portage, MI, 49002 United StatesPharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services. Drug Development Services • full range of pharmacokinetic and ADME services for IND/NDA • vivarium with skilled technical staff • LC-MS/MS method development and validation • FDA Crystal City guidelines • GLP compliant sample analysis Biochemistry Services • cell-based assays • protein expression o prokaryotic (E.coli) o eukaryotic (mammalian, insect cell/baculovirus) • protein purification • ligand binding assays • isothermal denaturation • enzyme inhibitor characterization and mechanism • fluorescence polarization and other fluorescence based assays • biomarker assays • ELISA • MSD electrochemiluminescence Bioanalytical Services • rapid screening methods • method development and validation • FDA Crystal City • OECD • preclinical pharmacokinetics • PK/PD assessment • toxicokinetic investigations of absorption and clearance • bioavailability/bioequivalence • ocular PK • cassette (n-in-1) dosing and analysis • prodrug and metabolite PK Assays and Assay Development • immunosorbent assays • traditional ELISA (HRP, AP) • ECL (Meso Scale Discovery format) technologies • development of multiplex immunoassays using MSD technology • cell-based assays: signal transduction (eg cAMP) • ligand binding assays • radio-isotope • isothermal denaturation • fluorescence intensity and polarization • enzyme assays and kinetics • inhibitor mechanism and validation • MSD Certification • Human Aβ42 • Human Total Tau Ophthalmic Research Services • pharmacokinetics/ADME • pharmacology and biochemistry • specialized dosing • specialized tissue and fluid collection • precise sample processing and bioanalysis • biomarker assays • MSD electrochemiluminescence • standard ELISA Ocular Efficacy Models • VEGF induced retinal vascular leakage (wet AMD) • blue light damage (dry AMD) • STZ induced diabetic retinopathy • laser induced CNV • LPS induced Uveitis • allergic response

6710 Quality Way Portage MI, 49002PharmOptima’s proven approach to drug discovery and optimization focuses on our ability to maximize your program's success by developing customized solutions for your intellectual property problems and providing the highest quality data in a rapid timeframe to move your compound up the value chain. Founded by scientists with broad expertise and years of pharmaceutical experience, we truly understand the value of solving the complex problems associated with drug development. Our multidisciplinary scientific team consults with you to provide research strategies to optimize your success.

28595 Orchard Lake Road, Ste. 301 Farmington Hills, MI 48334 About us QUEST Research Institute is one of a few multi-specialty, dedicated research sites in the Metro Detroit area. Founded on the desire to bring the local community access to new treatments following strict, FDA guidelines, QUEST has flourished and is now a Preferred Provider with several Pharmaceutical Sponsors and CRO's. Our site includes ten Investigators with extensive research experience in therapy areas such as Internal Medicine, Neurology, Rheumatology, Pain, Vaccines and Women's Health. We offer an in-patient facility and experienced clinical staff to support specialization in complex, early phase clinical research in a variety of diseases, but also participate in later phase trials through Phase IV. Prompt start-up, an experienced staff and strong recruitment and retention strategies are part of every trial we implement. The average tenure of our staff is seven years with all being educated on standard FDA requirements, respect for Volunteer's Rights and ICH/GCP Guidelines. Each research study is carefully planned and conducted to accommodate sponsor expectations and deadlines, while never compromising patient care.

28595 Orchard Lake Road, Ste. 301 Farmington Hills, MI, 48334 United States About us QUEST Research Institute is one of a few multi-specialty, dedicated research sites in the Metro Detroit area. Founded on the desire to bring the local community access to new treatments following strict, FDA guidelines, QUEST has flourished and is now a Preferred Provider with several Pharmaceutical Sponsors and CRO's. Our site includes ten Investigators with extensive research experience in therapy areas such as Internal Medicine, Neurology, Rheumatology, Pain, Vaccines and Women's Health. We offer an in-patient facility and experienced clinical staff to support specialization in complex, early phase clinical research in a variety of diseases, but also participate in later phase trials through Phase IV. Prompt start-up, an experienced staff and strong recruitment and retention strategies are part of every trial we implement. The average tenure of our staff is seven years with all being educated on standard FDA requirements, respect for Volunteer's Rights and ICH/GCP Guidelines. Each research study is carefully planned and conducted to accommodate sponsor expectations and deadlines, while never compromising patient care.

The Old GlassworksQuotient Bioresearch provides bioanalytical, metabolism and radiochemical services.

4488 ChandlerRochem provides chemicals, pharmaceutical products, regulatory services, and internal compliance.

9256 El Dorado Avenue Kalamazoo, MI 49009Research Vibe provides strategic consulting, holistic product development, and research design.

Kalamazoo, MI United StatesResearch Vibe provides strategic consulting, holistic product development, and research design.

2150 Miller Drive, Suite ARMC Pharmaceutical Solutions offers a Bolt On CMC service that allows for product development outsourcing for pharmaceutical development projects within small, medium and large pharmaceutical organizations. RMC has a complete team for CMC development, including technical experts in manufacturing, analytical and formulations sciences, as well as a quality assurance team skilled in internal and external audits and monitoring in GxP environments, as well as the internal responsibilities of a quality unit, such as batch release, training, document control and archival and quality system implementation and management.

4355 Varsity Dr. Ste. ERubicon offers whole genome analysis (WGA), whole transcriptome analysis (WTA ) and whole methylation analysis (WMA) of biospecimens including formalin-fixed tissue, plasma/serum/urine, buccal swabs and single cells.

Ann Arbor, MI United StatesRubicon offers whole genome analysis (WGA), whole transcriptome analysis (WTA ) and whole methylation analysis (WMA) of biospecimens including formalin-fixed tissue, plasma/serum/urine, buccal swabs and single cells.

3005 Boardwalk Drive Ann Arbor, MI, 48108 United StatesRTI Health Solutions is the place you turn when you need substantiated, authoritative evidence and advice. We are scientists first—academically-trained, credentialed researchers who know how and when to apply the appropriate research methodologies to your real-world applications and situations. We care about doing what’s right and what’s relevant, so you can make good, safe, and timely decisions about your pharmaceutical, medical device, or diagnostic products. Full range provider of health economics and outcomes research (HEOR), RWE, market access and pharmacoepidemiology services. Also a niche provider of GI clinical trials. Multinational & Multidisciplinary: A global perspective Located across the US and Europe, our staff have led projects in approximately 70 countries. Their experience is diverse; encompasses economics, public health, psychology, epidemiology, statistics, engineering, and other disciplines; and spans both developed and emerging markets, so we can help you with an array of projects in any region of interest. Expertise: Access to key thought leaders We attract and retain top talent across each of our practice areas, so you always have access to key thought leaders in drug development, commercialization, and safety. Nearly 80% of our researchers hold master's or doctorate degrees. Nearly all are published in their fields, many serve as peer-reviewers and editors for research journals, and several maintain university and industry advisory appointments.

46430 Peary Court Novi, MI, 48377 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

4767 Broadmoor Ave SE, Suite #5 Kentwood, MI, 49512 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

1180 East Ellsworth Road Ann Arbor, MI, 48108 United StatesScientist.com is the world’s largest marketplace for medical research. We help pharmaceutical scientists discover life-saving medicines in less time and at lower cost. Our mission is to make it possible to cure all human disease by 2050. By connecting scientists and enabling them to exchange ideas and transact seamlessly online, Scientist.com is speeding up and reducing the cost of medical research. We were founded in 2007, launched our first research outsourcing marketplace in 2008 and built our first enterprise marketplace for Pfizer in 2009. Today, we operate enterprise marketplaces for 24 of the world’s top 30 pharmaceutical companies, 100+ biotechnology companies and the US National Institutes of Health (NIH).

966 Hungerford AvenueResearch Scientific Services offers maintenance, repair, and sale of mass spectrometers.

301 Michigan Street NE, Suite 580Sequenom sells genetic analysis products that can be used for DNA methylation analysis, SNP genotyping, gene expression analysis, rare mutation profiling, methylation analysis and quantitative gene expression.

Ann Arbor, MI United StatesSoftware Innovations provides VoIP telephone services and software development services.

Unit 6 Regents Drive,SCM Pharma provides small and medium-scale sterile and non-sterile manufacturing, filling, development and packaging services.

674 S. Wagner Road Ste. 100 Ann Arbor, MI, 48103 United StatesSwift Biosciences develops and commercializes NGS Library Preparation Kits that enable technologies for genomics, translational, and clinical research. Our proprietary technologies expand the range of sample inputs to extend the applications of next-generation sequencing (NGS). Swift Library Kits are designed to maximize data output, provide the most comprehensive coverage available on the market and reduce sequencing costs. Our products are designed to facilitate library normalization and to analyze DNA and RNA samples for applications including Liquid Biopsy (circulating, cell-free DNA), Methylation Sequencing, Whole Genome, Exome and Transcriptome Sequencing as well as Chromatin studies, from low input quantities and from Formalin-Fixed, Paraffin-Embedded samples. The mission of Swift is to provide research tools for long term improvements in the health of individuals and their communities all around the world, specifically in the fight against cancer and understanding the complexities of inherited diseases. The tools developed in our efforts are directly applicable to research in agrigenomics, biotechnology, metagenomics, and the pharmaceutical industry.

100 Michigan St. NESpectrum Health is a not-for-profit health system who offers its medical specialties and laboratory services to support patient care and research.

3250 Plymouth Rd Suite 303 Ann Arbor, MI, 48105 United StatesAdvaita Bioinformatics develops comprehensive bioinformatics tools that bridge the gap between the ability to gather and interpret genomic variants, transcriptomics, proteomics data, and other OMICS data. Our advanced methods and platform provide researchers with the most advanced and secure tools to understand underlying phenomena at a systems biology level while minimizing false positives. Advaita’s HIPAA compliant applications allow users to quickly and intuitively understand expression and variant data and combine various ‘omics data to quickly gain deep biological understanding. Advaita's services span the entire workflow from basic processing of FastQ files to deep interpretation of integrated omics data for subtyping and feature identification. Our scientific staff have a combined 200+ publication with over 10,000 citations. While not exhaustive, here are some of the most common services we provide: • Group Comparisons: one- and two-way ANOVA, t-test, Chi-square test, Categorical Data analysis methods • Unsupervised Learning/ Multivariate Methods: PCA, Hierarchical and k-means Clustering, Gaussian Mixture Models (EM), PINS (proprietary methodology) • Statistical Modeling and Classification: Neural Nets, Support Vector Machines, Decision Trees, Random Forests, Logistic/ LASSO Regression, Linear Regression • Genotype Associations: GWAS • Systems Biology: Topological Algorithms for Ranking Biomolecular Pathways,Gene Ontology Pruning Methods, Agent-Based Modeling, Parameter Sensitivity/Uncertainty Analysis • Functional Interpretation & Analysis: Predicted miRNA Analysis, Gene Ontology Analysis with advanced pruning, Pathway Analysis using “Impact Analysis”, Disease Analysis, Meta-Analysis, Variant Annotation & Prioritization • Omics Data Types: Transcriptomics (microarray, RNASeq, NanoString nCounter), Genomics (WGS, WES, SNP arrays), Proteomics (Mass Spec, Multiplexed Cytokines), Metabolomics • Programming Languages/ Platforms: R, Bioconductor, Python, SQL, Perl, Unix, Java • Clinical/ Biological Domains: Type II Diabetes, Acute Respiratory Distress Syndrome, Pediatric Acute Liver Failure, Trauma/ Hemorrhagic Shock (serum and hepatocytes), Sepsis/ MODS, Ischemia/ Reperfusion, Wound Healing, Tuberculosis, Pre-Eclampsia, Alzheimer’s Disease, Cancer

426 Thompson Street, P.O. Box 1248, Ann Arbor, MI 48104-2321Survey Research Center provides social science research and sample survey data collection.

4560 Danvers Grand Rapids, MI 49512 USASurefil provides filling to personal care and OTC liquids, lotions, creams and gels.

Grand Rapids, MI United StatesSurefil provides filling to personal care and OTC liquids, lotions, creams and gels.

3224 US HWY 41 W, Suite 120Synaptech offers in vivo behavioral testing

Ann Arbor Michigan USAFounded in 1989, Thorlabs has its headquarters in Newton, NJ. This location is also home to our mechanics, optics, fiber, advanced systems technology, and advanced applications teams as well as one of our three distribution warehouses. On-site manufacturing allows us to customize our products quickly and efficiently to meet specialized customer requests. Our technical support team, call center, marketing, and web development teams make their homes in Newton as well, and are dedicated to providing comprehensive customer support and services.

540 Avis Drive, Suite A Ann Arbor MI 48108 USATSRL provides permeability classification, pharmacokinetic modeling and simulation, and formulation scale up services.

Ann Arbor, MI United StatesTSRL provides permeability classification, pharmacokinetic modeling and simulation, and formulation scale up services.

100 Phoenix Drive Ann Arbor, MI 48108At Truven Health Analytics™, our purpose is to make healthcare better — lower costs, improved quality, better results. Simple words. Yet remarkably complex concepts. But that's not stopping us. Or our customers. Every day, we get to work with smart, passionate professionals, from every facet of the industry, as they manage change and implement strategies that will achieve exactly those outcomes. Our customers are healthcare payers and providers. In both the private and public sectors. They're researchers and suppliers. Regulators. Movers and shakers in each piece and part of the healthcare world. With this broad view of healthcare, we're able to see when new challenges are just beginning to emerge. And that's when we begin working on new solutions. Data. We're driven by it. Known for our exacting collection and secure management of data, we've worked with clinical evidence, claims, clinical, and other healthcare data for more than 40 years. We know the challenges to watch for, what to do about them — and how to recognize new ones. Like finding new ways to measure risk for providers who take on more of it, and payers who contract for it. Or integrating data to deliver the solutions today's converging healthcare interests demand. Analytics. Because data alone is just numbers and letters. The need for reliable insights from data demands proven analytics. Our methodologies and algorithms are uniformly trusted across the industry to deliver critical information that leads to confident decisions. Coupled with flexible reporting, integration, and consulting services, our sophisticated analytics enable our customers to make their part of healthcare better, faster. Domain expertise. We have it. We really have walked in our customers' shoes. We've worked in their environments. That level of understanding, plus our leading data management capabilities and advanced analytics, are why our customers turn to us as their partner to deliver quality, reduce costs, and yield greater value in healthcare.

Phadia US Inc. 4169 Commercial Ave. Portage, MI 49002Phadia provides assay development expertise and tests for immunogenicity assessment of biologicals - from R&D to post-market monitoring utilizing 40+ years of expertise in immunology and assay development. Formerly, Swedish-based Phadia Ab, we are now the Immunodiagnostics division of Thermo Fisher Scientific.

The Wellhoff Center 7190 S. Brooklyn Rd. Jackson MI 49201 USATransPharm Preclinical Solutions is an AAALAC accredited and PHS assured facility that offers in vivo and in vitro services for infectious disease research.

7190 S. Brooklyn Rd Jackson, Michigan, 49201 United StatesTransPharm Preclinical Solutions is an AAALAC accredited and PHS assured facility that offers in vivo and in vitro services for infectious disease research.

900 Victors Way Suite 328 Ann Arbor, Michigan, 48108 United StatesA2PG offers model-based drug development consulting services focusing on population pharmacokinetic and pharmacodynamic modeling, and model-based clinical trial simulations.

17336 Michigan 60 Vandalia, MI, 49095 United States

1072 BIRB 2360 Bonisteel Blvd. Ann Arbor, MI 48109-2108The Functional MRI Laboratory is an interdisciplinary unit organized under the University of Michigan Office of Research, (UMOR). The Functional MRI Laboratory is dedicated to supporting research on the structures and functions of the brain that underlie cognitive and affective processes, and research on functional MRI and associated research tools. The Laboratory’s mission is to maintain an environment that will enhance the excellence of research using fMRI and associated technologies by providing a well-equipped physical facility and appropriate intellectual support services for investigators. On the left you will find links to our contact information and will be able to learn more about the faculty, administration, and students associated with our lab.

210 Washtenaw Avenue Ann Arbor, MI, 48109 United StatesThe Center for Structural Biology (CSB), housed in the Life Sciences Institute, is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

109 Zina Pitcher Place Ann Arbor, MI, 48109 United StatesTo provide many modern imaging systems

1500 East Medical Center Drive Ann Arbor, MI, 48109 United StatesTo support translational research studies that evaluate interventions directed at improving health outcomes of people with diabetes,

1600 Huron Parkway Ann Arbor, MI, 48105 United StatesThe Clinical Research Informatics team supports MICHR's mission to enable and enhance clinical and translational research by providing cutting-edge informatics software and services.

210 Washtenaw Avenue Ypsilanti, MI, 48197 United StatesTo provide a full range of crystallographic services ranging from crystallization through structure analysis and homology modeling.

Ann Arbor, MI United StatesUniversity of Michigan Gut Peptide Research Center offers its facilities to support proteomics, molecular biology, cell biology, and in vivo studies.

503 Thompson Street, Ann Arbor, MI, USAUniversity of Michigan offers research in many areas including natural sciences, environment, and biomedical.

Ann Arbor, MI United StatesUniversity of Michigan offers research in many areas including natural sciences, environment, and biomedical.

210 Washtenaw Avenue Ann Arbor, MI, 48109 United StatesTo provide expertise and resources for U-M researchers and others to use modern high-throughput screening (HTS) approaches in tackling basic biology or novel drug discovery projects.

2800 Plymouth Road, B10, G090, Ann Arbor, MI 48109 USAThe in-vivo Animal Core (IVAC) serves as a research resource in support of early, preclinical stage, translational research. Biomedical research has sustained a conceptual shift re-emphasizing translational research. Translation of bench side discoveries is often hampered by a lack of meaningful and predictive preclinical research (animal modeling). The design and interpretation of preclinical studies require specialized expertise which ULAM is now prepared to offer through enhanced facilities, staff and faculty. The IVAC Mission is to excel in project-specific preclinical in-vivo studies. Using University resources and accomplished ULAM professionals specializing in diverse fields, IVAC can optimize the design, execution, interpretation, and reporting of in-vivo studies to guide projects through early translational milestones. Services listed below can be utilized individually or combined as a full service, based on the needs of the investigator.

2800 Plymouth Road Ann Arbor, MI, 48109 United StatesTo create and research health interventions that inspire informed health decisions, broaden access to health information, and advance the field of health communications.

210 Washtenaw Ave. Ann Arbor, MI, 48109 United States

Center Drive Ann Arbor, MI, 48103 United StatesThe Transgenic Facility routinely produces transgenic rats for biomedical research

1150 East Medical Center Drive Ann Arbor, MI, 48109 United StatesThe Epigenomics Core, launched in 2015 as part of the UMMS Office of Research and Medical School's Strategic Research Initiative, provides resources and services to prepare samples for analysis in epigenetic regulation in both genome-wide and locus-specific manners. The Epigenomics Core is the newest member of the Biomedical Research Core Facilities.

1011 North University Avenue Ann Arbor, MI, 48109 United StatesTo support development of new knowledge in oral health science and related fields that will contribute to improved health.

1000 Wall Street Ann Arbor, MI, 48105 United StatesThe Metabolomics Core, part of the BRCF in the Medical School Office of Research, measures concentrations of small molecules in biological samples on a recharge basis.

1150 West Medical Center Drive Ann Arbor, MI, 48109 United StatesThe Proteomics & Peptide Synthesis Core provides access to research services in peptide synthesis, proteomics and protein analysis by mass spectrometry and other techniques

109 Zina Pitcher Place Ann Arbor, MI, 48109 United StatesTo offer state-of-the-art equipment for microscopic imaging, including fluorescence microscopy, as well as scanning and transmission electron microscopy.

1500 East Medical Center Drive Ann Arbor, MI, 48109 United StatesTo provide the clinical staff, resources, and infrastructure necessary to conduct human clinical research protocols at the University of Michigan

339 East Liberty Street Ann Arbor, MI, 48104 United StatesCLASS Laboratory is a national research reference laboratory and unit of The University of Michigan, School of Public Health, Department of Epidemiology.

1500 East Medical Center Drive Ann Arbor, MI, 48109 United StatesTo provide echocardiographic assessment of cardiac performance of both small (mouse, rats and superficial embryonic) and large (rabbit, canine, primates, pigs and sheep) animal models.

Ann Arbor, MI, 48105 United StatesTo provide expertise, advice, training, and equipment for the microscopic and morphometric analysis of biologic samples in support of research focused on diabetes

Ann Arbor, MI, 48109 United Stateskey responsibility of ULAM is to provide guidance for the University’s animal care and use program campus-wide.

4096 - Katz BuildingUniversity of Alberta Institute for Biomolecular Design offers protein identification, digestion, molecular weight determination, hydrolysis, amino acid analysis and peptide synthesis services.

428 Church Street Ann Arbor, MI, 48109 United StatesThe Pharmacokinetics (PK) Core aims to facilitate researchers' efforts to discover new medicines, obtain research funding, file patent applications, and publish academic research findings for both preclinical and clinical pharmacokinetic applications, including lead compound modeling, dose optimization, and clinical trials. In the core's short history, we have studied the preclinical PK and drug metabolism of more than 2000 compounds and have been involved in 18 human clinical PK studies. We have contributed to more than 100 grant applications, which resulted in over $43 million in funding to the University of Michigan. We have provided services to more than 70 U-M labs, and 20 external labs. Our work has resulted in over 30 joint manuscripts, with five patents issued and six pending.

1600 Huron Parkway Building 520- 3352 Ann Arbor, MI, 48109 United StatesThe Pharmacokinetics (PK) Core aims to facilitate researchers' efforts to discover new medicines, obtain research funding, file patent applications, and publish academic research findings for both preclinical and clinical pharmacokinetic applications, including lead compound modeling, dose optimization, and clinical trials. In the core's short history, we have studied the preclinical PK and drug metabolism of more than 2000 compounds and have been involved in 18 human clinical PK studies. We have contributed to more than 100 grant applications, which resulted in over $43 million in funding to the University of Michigan. We have provided services to more than 70 U-M labs, and 20 external labs. Our work has resulted in over 30 joint manuscripts, with five patents issued and six pending.

Building 520, North Campus Research Complex 1600 Huron Parkway Ann Arbor, MI, 48109 United StatesThe Pharmacokinetics (PK) Core aims to facilitate researchers' efforts to discover new medicines, obtain research funding, file patent applications, and publish academic research findings for both preclinical and clinical pharmacokinetic applications, including lead compound modeling, dose optimization, and clinical trials. In the core's short history, we have studied the preclinical PK and drug metabolism of more than 2000 compounds and have been involved in 18 human clinical PK studies. We have contributed to more than 100 grant applications, which resulted in over $43 million in funding to the University of Michigan. We have provided services to more than 70 U-M labs, and 20 external labs. Our work has resulted in over 30 joint manuscripts, with five patents issued and six pending.

930 North University Avenue Ann Arbor, MI, 48109 United StatesTo provide technical services.

1150 East Medical Center Drive Ann Arbor, MI, 48109 United StatesTo offer mass spectrometry services to the University of Michigan Medical School and the research community on a recharge basis

210 Washtenaw AvenueUniversity of Michigan Life Sciences Institute offers chemical genomics, high throughput screening, structural biology, stem cell biology, DNA sequencing, flow cytometry, and NMR services.

Detroit, MI, 48201 United StatesTo provide state-of-the-art technology for characterization of protein identity, modification and differential expression and to serve as a resource for training, education and consultation for proteomic applications to MDRC members.

1137 Catherine Street Ann Arbor, MI, 48109 United StatesTo enhance understanding of the function of molecules, cells, tissues and organisms with an emphasis on their relation to human biology and medicine

1500 East Medical Center Drive Ann Arbor, MI, 48109 United StatesTo provide technical support and training of investigators developing or performing intervention and other geriatric research projects examining the aging phenotype and outcomes research.

1011 North University Avenue Ann Arbor, MI, 48109 United StatesTo provide histological services using standard histological techniques. The core specializes in sectioning of hard (demineralized) tissues.

930 N. University Ann Arbor,, MI, 48109-1055 United StatesThe Walter lab leverages tools from chemical biology, analytical chemistry, biophysics, biochemistry, molecular biology, cell biology, and bioinformatics to define and unleash the powers of RNA biology and DNA nanotechnology. RNA is a magical molecule that both started life and sustains it today. Over 75% of our genome encodes highly conserved non-coding RNA molecules, compared with only <2% that encodes proteins. How this RNA machinery broadly guides cellular function – through the maintenance, processing and regulated expression of all genetic information – is still poorly understood. For an inspiring read on the prospects of RNA research, please check out this Paper. By comparison, DNA is better understood as the genetic blueprint of life, but recently its utility has dramatically expanded as a scaffold for nanodevices and nanorobots, heralding a modern materials science.

Ann Arbor, MI United StatesUniversity of Michigan Medical School Biomedical Research Core Facilities provides DNA sequencing, flow cytometry, protein synthesis and analysis services.

Ann Arbor, MI United StatesThe University of Michigan Biomedical Research Core Facilities (BRCF), part of the Medical School Office of Research, is a collection of centralized labs and services offering state-of-the-art instruments and resources to faculty and staff.

333 Bostwick Ave N.E. Grand Rapids, MI 49503The Confocal Microscopy and Quantitative Imaging Core provides optical imaging services for Van Andel Research Institute (VARI) and collaborating institutions. Its goal is to serve the VARI community with state-of-the-art imaging resources to address a broad variety of research questions, as well as offering the expertise to train researchers to use these resources effectively.

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAThe Flow Cytometry Core is dedicated to providing high quality, comprehensive cytometry services. Guidance in assay development by core personnel enables investigators to implement most flow cytometric assays. Diligent equipment maintenance ensures reliable performance in data generation and robust sorting capacity. Once trained, investigators may acquire/analyze their own data or they may choose to have core personnel perform the service for them (excluding sample preparation or pre-analytic work). The core provides training for independent operation of all equipment except the MoFlo Astrios. Consultations and unassisted data analysis are free of charge.

46701 Commerce Center Dr Plymouth, MI, 48170 United StatesVelesco provides analytical method development and validation, drug formulation services, and early stage clinical supplies.

2215 Fuller Rd Ann Arbor, MI 48105Since 1953, VA Ann Arbor Healthcare System (VAAAHS) has provided state-of-the-art healthcare services to the men and women who have so proudly served our nation. We consider it our privilege to serve your healthcare needs in any way we can. More than 65,000 Veterans living in a 15-county area of Michigan and Northwest Ohio utilized the VAAAHS in fiscal year 2015. The main hospital campus located in Ann Arbor serves as a referral center for specialty care and operates 109 acute care beds and 40 Community Living Center (extended care) beds. More than 800,000 outpatient visits were made at our facilities in fiscal year 2015; there were more than 5,000 inpatient episodes of care provided in the hospital and extended care center.

26105 Orchard Lake Road Suite 311 Farmington Hills, MI 48334 USAVectech Pharmaceutical Consultants provides scientific and engineering services to the pharmaceutical, biotechnology and medical device industries.

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAVARI’s Pathology and Biorepository Core integrates anatomic pathology expertise with biorepository and biospecimen science for assisting investigator research. The Pathology and Biorepository Core builds upon historical strengths in standard histology, microscopy, and biobanking, along with novel technologies to test and apply best practices in biospecimen science. This focus on pathology provides complementary emphasis on high-quality biospecimens and interpretable results with which to validate experimental models and extend them to clinical samples, thereby advancing the Institute’s mission. The Pathology and Biorepository Core is led by Core Director Dr. Scott Jewell, who has extensive expertise in experimental pathology, immunology, and biobanking, and Associate Director of the Pathology and Biorepository Core Dr. Galen Hostetter, a board-certified pathologist. They have ongoing studies on the effects of preanalytical variables in tissue collection and transport that affect the integrity of downstream analytes. The assessment of oncogenes and immunomodulators in tumor tissues and the application of genomic and epigenomic assays for biospecimens are among the services that the core provides. The VARI Biorepository is nationally and internationally recognized, serving as the NCI Comprehensive Biospecimen Resource for the Cancer Human Biobank (caHUB) and providing biorepository services for the Multiple Myeloma Research Foundation.

333 Bostwick Ave N.E. Grand Rapids, MI 49503The mission of the Vivarium and Transgenics Core is to develop, provide, and support high quality mouse modeling services for VARI investigators, collaborators, and the greater research community. The VARI Vivarium is a state-of-the-art facility that includes a high containment barrier. All procedures are conducted according to the National Institutes of Health’s Guide for the Care and Use of Laboratory Animals. VARI is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. The staff provides rederivation, surgery, dissection, necropsy, breeding, weaning, tail biopsies, sperm and embryo cryopreservation, animal data management, and health-status monitoring. Transgenic mouse models are produced on request for project-specific needs. The Vivarium and Transgenics Core is led by Director Bryn Eagleson, who has extensive experience in lab animal science and transgenic technology. The core is committed to the highest of quality in animal standards and care as well as providing strong, dedicated support for the research community. The Vivarium’s staff understands how important providing excellent animal care is to producing quality research. Please acknowledge VARI’s Vivarium and Transgenics Core in publications using the following wording or similar: We thank Van Andel Research Institute’s Vivarium and Transgenics Core for its contributions to this work.

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAThe mission of the Vivarium and Transgenics Core is to develop, provide, and support high quality mouse modeling services for VARI investigators, collaborators, and the greater research community. The VARI Vivarium is a state-of-the-art facility that includes a high containment barrier. All procedures are conducted according to the National Institutes of Health’s Guide for the Care and Use of Laboratory Animals. VARI is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. The staff provides rederivation, surgery, dissection, necropsy, breeding, weaning, tail biopsies, sperm and embryo cryopreservation, animal data management, and health-status monitoring. Transgenic mouse models are produced on request for project-specific needs. The Vivarium and Transgenics Core is led by Director Bryn Eagleson, who has extensive experience in lab animal science and transgenic technology. The core is committed to the highest of quality in animal standards and care as well as providing strong, dedicated support for the research community. The Vivarium’s staff understands how important providing excellent animal care is to producing quality research. Please acknowledge VARI’s Vivarium and Transgenics Core in publications using the following wording or similar: We thank Van Andel Research Institute’s Vivarium and Transgenics Core for its contributions to this work.

333 Bostwick Ave N.E. Grand Rapids, MI 49503VARI’s Pathology and Biorepository Core integrates anatomic pathology expertise with biorepository and biospecimen science for assisting investigator research. The Pathology and Biorepository Core builds upon historical strengths in standard histology, microscopy, and biobanking, along with novel technologies to test and apply best practices in biospecimen science. This focus on pathology provides complementary emphasis on high-quality biospecimens and interpretable results with which to validate experimental models and extend them to clinical samples, thereby advancing the Institute’s mission. The Pathology and Biorepository Core is led by Core Director Dr. Scott Jewell, who has extensive expertise in experimental pathology, immunology, and biobanking, and Associate Director of the Pathology and Biorepository Core Dr. Galen Hostetter, a board-certified pathologist. They have ongoing studies on the effects of preanalytical variables in tissue collection and transport that affect the integrity of downstream analytes. The assessment of oncogenes and immunomodulators in tumor tissues and the application of genomic and epigenomic assays for biospecimens are among the services that the core provides. The VARI Biorepository is nationally and internationally recognized, serving as the NCI Comprehensive Biospecimen Resource for the Cancer Human Biobank (caHUB) and providing biorepository services for the Multiple Myeloma Research Foundation.

333 Bostwick Ave N.E. Grand Rapids, MI 49503The Bioinformatics and Biostatistics Core provides efficient, high quality computational and statistical expertise for Van Andel Research Institute laboratories and external organizations in the analysis and interpretation of data. The core maintains sequencing pipelines for processing and analyzing genomic data sets, develops custom tools and applications for quantitative image analysis, provides access to a variety of proprietary and open-source resources, and oversees the maintenance and development of high-performance computing capabilities. Services include: Statistical consulting Experimental design Research proposal development Sample size determination Randomization procedures Manuscript preparation and data deposition Genomic variant detection and annotation Transcript/isoform differential expression DNA copy number determination Systems-level analysis such as gene-set and network-based analysis Analysis, interpretation, and presentation of small and large data sets Time-series data Tumor growth Drug response Custom application and tool development

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAThe Small Animal Imaging Facility (SAIF) at Van Andel Research Institute (VARI) provides multiple imaging and image analysis tools for use with biologic specimens and rodents. The core’s imaging capabilities include digital X-ray, high-resolution micro computed tomography (CT), micro single photon emission computed tomography (SPECT), micro positron emission tomography (PET), micro-ultrasound, and an optical imager for in vivo bioluminescence and fluorescence imaging. SAIF is committed to developing advanced capabilities with state-of-the-art imaging modalities to fulfill the needs of VARI’s biomedical research community. SAIF’s research interests include the development of next-generation imaging probes for tumor detection and of imaging technologies that can offer anatomic and functional information to biomedical investigators. Imaging is used in modern medicine to diagnose and monitor disease progression. In recent years, small animal imaging has been increasingly recognized as an important facet of preclinical and translational research. This emerging field focuses on using non-invasive means to visualize the anatomic structures and physiologic activity in small research animals, primarily in rats and mice. Observing disease physiology and novel phenotypes in an intact, living system is one of the most significant advantages of imaging. In vivo imaging helps reduce the number of animals needed to acquire data and achieve results, thus reducing animal use and its associated costs, especially those linked to genetically engineered mice. Innumerable data points can be collected from the same animal, therefore more accurately mimicking a clinical study.

333 Bostwick Ave N.E. Grand Rapids, MI 49503The Small Animal Imaging Facility (SAIF) at Van Andel Research Institute (VARI) provides multiple imaging and image analysis tools for use with biologic specimens and rodents. The core’s imaging capabilities include digital X-ray, high-resolution micro computed tomography (CT), micro single photon emission computed tomography (SPECT), micro positron emission tomography (PET), micro-ultrasound, and an optical imager for in vivo bioluminescence and fluorescence imaging. SAIF is committed to developing advanced capabilities with state-of-the-art imaging modalities to fulfill the needs of VARI’s biomedical research community. SAIF’s research interests include the development of next-generation imaging probes for tumor detection and of imaging technologies that can offer anatomic and functional information to biomedical investigators. Imaging is used in modern medicine to diagnose and monitor disease progression. In recent years, small animal imaging has been increasingly recognized as an important facet of preclinical and translational research. This emerging field focuses on using non-invasive means to visualize the anatomic structures and physiologic activity in small research animals, primarily in rats and mice. Observing disease physiology and novel phenotypes in an intact, living system is one of the most significant advantages of imaging. In vivo imaging helps reduce the number of animals needed to acquire data and achieve results, thus reducing animal use and its associated costs, especially those linked to genetically engineered mice. Innumerable data points can be collected from the same animal, therefore more accurately mimicking a clinical study.

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAThe Bioinformatics and Biostatistics Core provides efficient, high quality computational and statistical expertise for Van Andel Research Institute laboratories and external organizations in the analysis and interpretation of data. The core maintains sequencing pipelines for processing and analyzing genomic data sets, develops custom tools and applications for quantitative image analysis, provides access to a variety of proprietary and open-source resources, and oversees the maintenance and development of high-performance computing capabilities. Services include: * Statistical consulting * Experimental design ** Research proposal development ** Sample size determination ** Randomization procedures * Manuscript preparation and data deposition * Genomic variant detection and annotation * Transcript/isoform differential expression * DNA copy number determination * Systems-level analysis such as gene-set and network-based analysis * Analysis, interpretation, and presentation of small and large data sets ** Time-series data ** Tumor growth ** Drug response * Custom application and tool development

333 Bostwick Ave N.E. Grand Rapids, MI 49503 USAThe Confocal Microscopy and Quantitative Imaging Core provides optical imaging services for Van Andel Research Institute (VARI) and collaborating institutions. Its goal is to serve the VARI community with state-of-the-art imaging resources to address a broad variety of research questions, as well as offering the expertise to train researchers to use these resources effectively.

333 Bostwick Ave N.E., Grand Rapids, MI 49503Van Andel Institute provides tissue, pathology, animal imaging, antibody, flow cyometry, cytogenetics, proteomics, microarray, sequencing, transgenic mouse, and xenotransplantation services.

430 Chemistry Bldg. 410 W. Warren Ave. Detroit, MI 48202 USAWayne State University School of Medicine Lipidomics Core Facility offers lipid profiling services.

4100 John R Detroit, Michigan 48201The mission of the Proteomics Core is to enhance the research productivity of KCI members by providing the equipment and trained personnel necessary for analysis of cellular proteome composition, protein modification, protein quantitation and protein interaction. Core Services Available Protein identification using nano-LC/MS/MS instruments Protein quantitation using spectral counting or stable isotope labeling with data acquired on Orbitrap Fusion or Orbitrap QExactive mass spectrometers Targeted protein quantitation using and the Multiple Reaction Monitoring strategy using the TSQ Vantage MS system Proteomic profiling using two-dimensional chromatographic separations or MuDPIT technologies Analysis of post translational modifications using nano-LC/MS/MS with fragmentation by ETD, HCD or CID Robotic protein digestion using the Genomic Solutions Investigator ProGest Protein interaction and protease activity analysis by fluorescence polarization measurement using the Beacon 2000 fluorescence polarization system or the Tecan Polarion microplate reader Fluorescence measurement using a QM-6 spectrofluorometer equipped for simultaneous dual emission recording and with removable dual emission polarizers all controlled by software on an accompanying work station Data Analysis using Mascot, Sequest, MaxQuant, X!tandem and Peaks algorithms with data compilation and secondary analysis using Scaffold. Instrumentation Thermo Fisher Orbitrap Fusion MS system with ETD and the Easy-LC nano-LC/MS/MS system. Proteome profiling, protein identification, protein quantitation by spectral counting, isobaric tags and SILAC as well as post translational modification identification and position localization. Thermo Fisher Q-Exactive Orbitrap MS system with Easy-LC nano-LC/MS/MS system. Proteome profiling, protein identification, protein quantitation by spectral counting, isobaric tags and SILAC. Thermo Fisher TSQ Vantage triple quadrupole nano-LC/MS/MS system. Protein quantitation by SRM and MRM. Thermo Finnegan LTQ-XL Linear Ion Trap nano-LC/MS/MS with ETD. Protein identification and post translational modification identification and position localization. MS Data Analysis using Sequest, PEAKS and X! Tandem algorithms on a two dual core processor work station with 4 terabyte raid 0 array for data storage and Scaffold for data secondary analysis and presentation. MS Data Analysis using Mascot with distiller and the quantitation package on a dedicated four x four core processor work station with 4 terabyte raid 0 array for data storage and Scaffold for data secondary analysis and presentation. Advion TriVersa nanospray source for fraction collection with continuous nanospray infusion from 96 or 384 well plates. The TriVersa is used with the LTQ-XL. Advion Nanomate 100 nanospray source for continuous infusion from 96 or 384 well plates. The nanomate is used with the TSQ Vantage. Genomic Solutions Investigator ProGest robot for automated digestion of up to 96 samples. Pathway Guide, Ingenuity Systems Software, GeneXplain and Genomatix software packages for data analysis are available to us through the Wayne State Applied Genomics Technology Center

4100 John R Detroit, Michigan, 48201 United StatesThe mission of the Proteomics Core is to enhance the research productivity of KCI members by providing the equipment and trained personnel necessary for analysis of cellular proteome composition, protein modification, protein quantitation and protein interaction. Core Services Available Protein identification using nano-LC/MS/MS instruments Protein quantitation using spectral counting or stable isotope labeling with data acquired on Orbitrap Fusion or Orbitrap QExactive mass spectrometers Targeted protein quantitation using and the Multiple Reaction Monitoring strategy using the TSQ Vantage MS system Proteomic profiling using two-dimensional chromatographic separations or MuDPIT technologies Analysis of post translational modifications using nano-LC/MS/MS with fragmentation by ETD, HCD or CID Robotic protein digestion using the Genomic Solutions Investigator ProGest Protein interaction and protease activity analysis by fluorescence polarization measurement using the Beacon 2000 fluorescence polarization system or the Tecan Polarion microplate reader Fluorescence measurement using a QM-6 spectrofluorometer equipped for simultaneous dual emission recording and with removable dual emission polarizers all controlled by software on an accompanying work station Data Analysis using Mascot, Sequest, MaxQuant, X!tandem and Peaks algorithms with data compilation and secondary analysis using Scaffold. Instrumentation Thermo Fisher Orbitrap Fusion MS system with ETD and the Easy-LC nano-LC/MS/MS system. Proteome profiling, protein identification, protein quantitation by spectral counting, isobaric tags and SILAC as well as post translational modification identification and position localization. Thermo Fisher Q-Exactive Orbitrap MS system with Easy-LC nano-LC/MS/MS system. Proteome profiling, protein identification, protein quantitation by spectral counting, isobaric tags and SILAC. Thermo Fisher TSQ Vantage triple quadrupole nano-LC/MS/MS system. Protein quantitation by SRM and MRM. Thermo Finnegan LTQ-XL Linear Ion Trap nano-LC/MS/MS with ETD. Protein identification and post translational modification identification and position localization. MS Data Analysis using Sequest, PEAKS and X! Tandem algorithms on a two dual core processor work station with 4 terabyte raid 0 array for data storage and Scaffold for data secondary analysis and presentation. MS Data Analysis using Mascot with distiller and the quantitation package on a dedicated four x four core processor work station with 4 terabyte raid 0 array for data storage and Scaffold for data secondary analysis and presentation. Advion TriVersa nanospray source for fraction collection with continuous nanospray infusion from 96 or 384 well plates. The TriVersa is used with the LTQ-XL. Advion Nanomate 100 nanospray source for continuous infusion from 96 or 384 well plates. The nanomate is used with the TSQ Vantage. Genomic Solutions Investigator ProGest robot for automated digestion of up to 96 samples. Pathway Guide, Ingenuity Systems Software, GeneXplain and Genomatix software packages for data analysis are available to us through the Wayne State Applied Genomics Technology Center

540 E. Canfield St.Wayne State University Michigan Proteome Consortium provides yeast two hybrid screening services

300 West Textile Road Ann Arbor, Michigan 48108

4100 John R Detroit, Michigan 48201The mission of the Microscopy, Imaging & Cytometry Resources (MICR) core is to enhance the peer reviewed funded research activities of WSU investigators whose research requires microscopy, imaging resources, flow cytometry, histology and related techniques. Core Services Available Confocal Microscopy, including both point scanning (Zeiss LSM 510, Zeiss LSM 410, Zeiss LSM 780, Leica TCS SP5) and spinning disk (Perkin Elmer UltraView) technologies. Multiphoton Microscopy, including Second Harmonic Generation imaging Fluorescent Microscopy Conventional, widefield epifluorescence (Zeiss ApoTome) Optical sectioning using Structured Illumination (Zeiss ApoTome) In vivo small animal imaging In vivo small animal Positron Emission Tomography (PET) imaging In vivo small animal Single Photon Emission Computed Tomography (SPECT/CT) imaging In vivo small animal X-Ray imaging In vivo small animal white light, fluorescence and bioluminescence imaging (Carestream In Vivo Xtreme, Carestream MS FX PRO) Long-term, live cell imaging. All confocal microscopes are outfitted with live cell imaging chambers to control CO2 flow, temperature and humidity Advanced Image Analysis, including 3D and 4D image reconstruction and quantitative measurements Cell analysis for data acquired using the benchtop cytometers and the FACSDiVa. These services range from simple one-color analysis of the cell cycle to multi-color, multi-laser analysis requiring expert knowledge of machine setup and color compensation Cell sorting (operator driven), using the FACSDiVa. The DiVa sorts up to 20,000 cells/second in a single or two-way sort or can deposit cells in wells of a variety of microwell plates using its automated cell deposition unit Cytometry Data analysis, using any of three offline workstations in the Hudson Webber Cancer Research Center (HWCRC) or one in the Prentis Cancer Research Building that provides access to licensed Cellquest, DiVa and FlowJo software for basic analysis and programs such as Modfit for cell cycle analysis. The researcher can undertake analysis after suitable training, or Core personnel will provide the service Expert consultation, including advide on the choice of application and experimental design -- contact us here Training is provided for every new user as well as refresher training for more experienced users, and workshops are provided, as announced On site support for use of equipment

4100 John R Detroit, Michigan, 48201 United StatesThe mission of the Microscopy, Imaging & Cytometry Resources (MICR) core is to enhance the peer reviewed funded research activities of WSU investigators whose research requires microscopy, imaging resources, flow cytometry, histology and related techniques. Core Services Available Confocal Microscopy, including both point scanning (Zeiss LSM 510, Zeiss LSM 410, Zeiss LSM 780, Leica TCS SP5) and spinning disk (Perkin Elmer UltraView) technologies. Multiphoton Microscopy, including Second Harmonic Generation imaging Fluorescent Microscopy Conventional, widefield epifluorescence (Zeiss ApoTome) Optical sectioning using Structured Illumination (Zeiss ApoTome) In vivo small animal imaging In vivo small animal Positron Emission Tomography (PET) imaging In vivo small animal Single Photon Emission Computed Tomography (SPECT/CT) imaging In vivo small animal X-Ray imaging In vivo small animal white light, fluorescence and bioluminescence imaging (Carestream In Vivo Xtreme, Carestream MS FX PRO) Long-term, live cell imaging. All confocal microscopes are outfitted with live cell imaging chambers to control CO2 flow, temperature and humidity Advanced Image Analysis, including 3D and 4D image reconstruction and quantitative measurements Cell analysis for data acquired using the benchtop cytometers and the FACSDiVa. These services range from simple one-color analysis of the cell cycle to multi-color, multi-laser analysis requiring expert knowledge of machine setup and color compensation Cell sorting (operator driven), using the FACSDiVa. The DiVa sorts up to 20,000 cells/second in a single or two-way sort or can deposit cells in wells of a variety of microwell plates using its automated cell deposition unit Cytometry Data analysis, using any of three offline workstations in the Hudson Webber Cancer Research Center (HWCRC) or one in the Prentis Cancer Research Building that provides access to licensed Cellquest, DiVa and FlowJo software for basic analysis and programs such as Modfit for cell cycle analysis. The researcher can undertake analysis after suitable training, or Core personnel will provide the service Expert consultation, including advide on the choice of application and experimental design -- contact us here Training is provided for every new user as well as refresher training for more experienced users, and workshops are provided, as announced On site support for use of equipment

4100 John R Detroit, Michigan 48201The Biostatistics Core is a resource for Cancer Center investigators in clinical, laboratory, population studies and prevention research. It is the objective of the Biostatistics Core to provide expertise in statistical science to ensure scientific rigor in study design, statistical analysis, and interpretation of cancer research data. Specifically, members of the Core: Develop experimental designs for clinical, laboratory, intervention, and observational studies Conduct statistical analyses and collaborate on interpretation of results Write statistical reports and make statistical presentations Provide statistical expertise in writing grant proposals and manuscripts Provide instruction in biostatistics to cancer researchers in journal clubs, seminar series and grand rounds presentations Evaluate new and conventional statistical methodology for applicability to cancer research projects and apply or adapt the methods as required Core biostatisticians collaborate with Cancer Center investigators in framing testable questions, devising experimental plans that make efficient use of experimental materials, patient populations and community participants. They ensure that there is sufficient statistical power to answer the research questions and that due consideration is given to issues of measurement, unbiased and efficient sample selection, unbiased assessment of outcomes, adequate follow-up and other details of implementation. They provide expertise on efficient collection and management of cancer research data and devise quality control procedures to ensure the validity and completeness of those data. During the planning stages of a study, the statistician devises an analysis plan consistent with the experimental design. Following the initial statistical analysis, the statistician evaluates the conformity of the data to the statistical assumptions, assesses the adequacy of the fit of the statistical model, investigates the effects of outlying or missing data points and assesses the sensitivity of the results to the presence of these observations. When conventional methods prove inadequate, conventional methods are modified or new methods applied. Statisticians are responsible for writing the Statistical Considerations sections of grant proposals and clinical protocols. They select and describe the statistical methods, write the results sections of manuscripts and collaborate on interpreting the results for collaborative projects.

4100 John R Detroit, Michigan, 48201 United StatesThe Biostatistics Core is a resource for Cancer Center investigators in clinical, laboratory, population studies and prevention research. It is the objective of the Biostatistics Core to provide expertise in statistical science to ensure scientific rigor in study design, statistical analysis, and interpretation of cancer research data. Specifically, members of the Core: Develop experimental designs for clinical, laboratory, intervention, and observational studies Conduct statistical analyses and collaborate on interpretation of results Write statistical reports and make statistical presentations Provide statistical expertise in writing grant proposals and manuscripts Provide instruction in biostatistics to cancer researchers in journal clubs, seminar series and grand rounds presentations Evaluate new and conventional statistical methodology for applicability to cancer research projects and apply or adapt the methods as required Core biostatisticians collaborate with Cancer Center investigators in framing testable questions, devising experimental plans that make efficient use of experimental materials, patient populations and community participants. They ensure that there is sufficient statistical power to answer the research questions and that due consideration is given to issues of measurement, unbiased and efficient sample selection, unbiased assessment of outcomes, adequate follow-up and other details of implementation. They provide expertise on efficient collection and management of cancer research data and devise quality control procedures to ensure the validity and completeness of those data. During the planning stages of a study, the statistician devises an analysis plan consistent with the experimental design. Following the initial statistical analysis, the statistician evaluates the conformity of the data to the statistical assumptions, assesses the adequacy of the fit of the statistical model, investigates the effects of outlying or missing data points and assesses the sensitivity of the results to the presence of these observations. When conventional methods prove inadequate, conventional methods are modified or new methods applied. Statisticians are responsible for writing the Statistical Considerations sections of grant proposals and clinical protocols. They select and describe the statistical methods, write the results sections of manuscripts and collaborate on interpreting the results for collaborative projects.

275 East HancockWayne State University School of Medicine Applied Genomics Technology Center (AGTC) provides DNA and RNA isolation, genotyping, sequencing, and microarry services.

4100 John R Detroit, Michigan 48201Mission of the Core The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by Distributing cancer models developed at Karmanos Cancer Institute Conducting in vivo testing of novel therapeutics Assisting investigators in many aspects of small animal research AMTEC interfaces with appropriate cores for follow-up sample analysis. Core Services Available Cancer Models Developed in KCI Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples. BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel - 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2 Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series in vivo Testing of Novel Therapeutics Pre-clinical testing of experimental therapeutics Generate documents for publication, grant/contract application and intellectual property application Generate new drug resistant or genetically targeted tumor lines Generate new xenograft models from human tissues Assist Investigators in All Aspects of Small Animal Research Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies Breeding and genotyping of genetically modified animals Small animal whole body Irradiation, surgery, tissue collection Train lab personnel for specialized techniques Provide consultation to generate genetically modified mouse strains

4100 John R Detroit, Michigan, 48201 United StatesMission of the Core The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by Distributing cancer models developed at Karmanos Cancer Institute Conducting in vivo testing of novel therapeutics Assisting investigators in many aspects of small animal research AMTEC interfaces with appropriate cores for follow-up sample analysis. Core Services Available Cancer Models Developed in KCI Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples. BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel - 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2 Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series in vivo Testing of Novel Therapeutics Pre-clinical testing of experimental therapeutics Generate documents for publication, grant/contract application and intellectual property application Generate new drug resistant or genetically targeted tumor lines Generate new xenograft models from human tissues Assist Investigators in All Aspects of Small Animal Research Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies Breeding and genotyping of genetically modified animals Small animal whole body Irradiation, surgery, tissue collection Train lab personnel for specialized techniques Provide consultation to generate genetically modified mouse strains

4100 John R Detroit, Michigan 48201The objectives of the Biobanking and Correlative Sciences (BCS) Core are to make available our expertise in the development and implementation of preclinical studies available to investigators, to facilitate the translation of novel therapeutics from bench to beside, and to perform pharmacodynamic endpoint studies for clinical trials. Additionally, the BCS will provide an organized, central biorepository of a diverse selection of high-quality human tissue specimens such as fresh, frozen, and paraffin embedded tissues that meet the best practices of the NCI for quality biospecimens for cancer research.

4100 John R Detroit, Michigan, 48201 United StatesThe objectives of the Biobanking and Correlative Sciences (BCS) Core are to make available our expertise in the development and implementation of preclinical studies available to investigators, to facilitate the translation of novel therapeutics from bench to beside, and to perform pharmacodynamic endpoint studies for clinical trials. Additionally, the BCS will provide an organized, central biorepository of a diverse selection of high-quality human tissue specimens such as fresh, frozen, and paraffin embedded tissues that meet the best practices of the NCI for quality biospecimens for cancer research.

4100 John R Detroit, Michigan 48201The mission of the Pharmacology Core is to provide state-of-the-art analytical technology and a broad range of pharmacology expertise to enable evaluation of critical pharmacological endpoints in clinical trials and preclinical studies. Core Services Available The Pharmacology Core offers the following services based on fee-for-service: Biospecimen Processing service provides a centralized resource for the acquisition, processing, and shipment of patient samples including blood, plasma, urine, peripheral blood mononuclear cell (PBMC), bone marrow, and tissue samples. All biospecimens are collected from patients who provided informed consent following an Institutional Review Board approved protocol. Specimen handling, processing, and shipment are in compliance with good laboratory practice (GLP) procedures, approved standard operating procedures, and regulatory requirements to ensure sample integrity and quality. A secure database that includes detailed information on the acquisition, processing, distribution of the samples along with related clinical data is maintained. Bioanalysis service provides development, validation, and implementation of analytical methods using high or ultra-high performance liquid chromatography (HPLC or UPLC) coupled with tandem mass spectrometer (LC-MS/MS), ultraviolet, photodiode array, or fluorescence detector for quantitative measurement of drugs, metabolites, and endogenous compounds in biological samples (e.g., biofluid, tissue, or cell culture samples). Method validation is provided based on the United States Food and Drug Administration Guidance for Bioanalytical Method Validation to ensure that a particular method is specific, sensitive, reliable, reproducible, and suitable for the intended analytical use. Rigorous quality assurance and quality control are provided for measurements of clinical and preclinical samples. LC-MS/MS based targeted metabolomics aims to measure predefined groups of metabolites that are involved in major metabolic pathways including carbohydrate, protein, and lipid metabolism, etc (Table 1). We strive to provide GLP-quality analytical service at competitive prices, and regularly customize assays to meet investigators’ needs. Our services spans from initial consultation for study design and sample collection, sample preparation, instrumental analysis, to final data analysis and interpretation.

4100 John R Detroit, Michigan, 48201 United StatesThe mission of the Pharmacology Core is to provide state-of-the-art analytical technology and a broad range of pharmacology expertise to enable evaluation of critical pharmacological endpoints in clinical trials and preclinical studies. Core Services Available The Pharmacology Core offers the following services based on fee-for-service: Biospecimen Processing service provides a centralized resource for the acquisition, processing, and shipment of patient samples including blood, plasma, urine, peripheral blood mononuclear cell (PBMC), bone marrow, and tissue samples. All biospecimens are collected from patients who provided informed consent following an Institutional Review Board approved protocol. Specimen handling, processing, and shipment are in compliance with good laboratory practice (GLP) procedures, approved standard operating procedures, and regulatory requirements to ensure sample integrity and quality. A secure database that includes detailed information on the acquisition, processing, distribution of the samples along with related clinical data is maintained. Bioanalysis service provides development, validation, and implementation of analytical methods using high or ultra-high performance liquid chromatography (HPLC or UPLC) coupled with tandem mass spectrometer (LC-MS/MS), ultraviolet, photodiode array, or fluorescence detector for quantitative measurement of drugs, metabolites, and endogenous compounds in biological samples (e.g., biofluid, tissue, or cell culture samples). Method validation is provided based on the United States Food and Drug Administration Guidance for Bioanalytical Method Validation to ensure that a particular method is specific, sensitive, reliable, reproducible, and suitable for the intended analytical use. Rigorous quality assurance and quality control are provided for measurements of clinical and preclinical samples. LC-MS/MS based targeted metabolomics aims to measure predefined groups of metabolites that are involved in major metabolic pathways including carbohydrate, protein, and lipid metabolism, etc (Table 1). We strive to provide GLP-quality analytical service at competitive prices, and regularly customize assays to meet investigators’ needs. Our services spans from initial consultation for study design and sample collection, sample preparation, instrumental analysis, to final data analysis and interpretation.

1726 Knollcrest Circle SE Grand Rapids, MI, 49546-4403 United StatesThe West Michigan Regional Laboratory (WMRL) is an AAALAC accredited, state of the art research and teaching facility, designed to administer the highest quality and humane care for animals used for research. Services WMRL provides a variety of services for instructors and researchers, including: quality animal care—365 days a year housing suitable for a variety of species, from mice to sheep surgical skill training utilizing human cadaveric specimens training available including regulatory compliance, animal handling, and surgical skills licensed veterinary technicians (LVTs) to assist in surgical and non-surgical procedures two large, well equipped surgical suites state of the art laparoscopic and orthopedic instrumentation, along with extensive surgical instrumentation imaging capabilities including ultrasound and C-Arm conference room/class room, catering, and special event coordination

4100 John R Detroit, Michigan 48201The Epidemiology Research Core (ERC) mission is to support population-based research by accessing metropolitan Detroit cancer cases and cancer registry data for use in approved research. The ERC provides epidemiology expertise and collaborates with researchers conducting investigations in cancer prevention, etiology, treatment and outcomes. This type of population-based cancer research is made possible by ERC accessing this data on behalf of researchers, which ensures confidentiality. Core Services Available Consultation. Consultation and collaborative research expertise focused on study design, proposal development, IRB applications, and interpretation of population-based local and national SEER data. Rapid Case Ascertainment. Rapid identification and ascertainment of eligible study participants, requiring review of all pathology reports indicating a cancer diagnosis at approximately 60 metropolitan area hospitals, clinics, pathology laboratories and radiation therapy facilities and rapid collection of patient demographic information. This speeds up case identification for population-based studies, with most cases identified within one to two months of diagnosis. Control Identification. Identification of population-based control groups for case-control study designs via random digit dialing, Centers for Medicaid and Medicare Services (CMS) records, Department of Motor Vehicles (DMV) records, and other mechanisms. Recruitment and Interviewing Support. Oversight and support of study participant recruitment and data collection via telephone, mailed and in-person interviews. Collection and Abstraction of Medical Records. Collection of medical records and abstracting of study-specific data which are not available in the MDCSS registry. Biospecimen Collection. Collection of biologic specimens, including blood, buccal cells, saliva and tumor blocks, from study participants and/or diagnosing hospitals including KCI and non-KCI facilities. Collection from KCI facilities is coordinated with the Biorepository Core. Database Query. Response to requests for population-based data requiring query of the MDCSS and/or the national SEER Limited-Use data files and SEER-Medicare files for descriptive analyses. Database Linkage. Linkage of outside data sources to MDCSS data for the collection of patient demographics, treatment and survival data.

4100 John R Detroit, Michigan, 48201 United StatesThe Epidemiology Research Core (ERC) mission is to support population-based research by accessing metropolitan Detroit cancer cases and cancer registry data for use in approved research. The ERC provides epidemiology expertise and collaborates with researchers conducting investigations in cancer prevention, etiology, treatment and outcomes. This type of population-based cancer research is made possible by ERC accessing this data on behalf of researchers, which ensures confidentiality. Core Services Available Consultation. Consultation and collaborative research expertise focused on study design, proposal development, IRB applications, and interpretation of population-based local and national SEER data. Rapid Case Ascertainment. Rapid identification and ascertainment of eligible study participants, requiring review of all pathology reports indicating a cancer diagnosis at approximately 60 metropolitan area hospitals, clinics, pathology laboratories and radiation therapy facilities and rapid collection of patient demographic information. This speeds up case identification for population-based studies, with most cases identified within one to two months of diagnosis. Control Identification. Identification of population-based control groups for case-control study designs via random digit dialing, Centers for Medicaid and Medicare Services (CMS) records, Department of Motor Vehicles (DMV) records, and other mechanisms. Recruitment and Interviewing Support. Oversight and support of study participant recruitment and data collection via telephone, mailed and in-person interviews. Collection and Abstraction of Medical Records. Collection of medical records and abstracting of study-specific data which are not available in the MDCSS registry. Biospecimen Collection. Collection of biologic specimens, including blood, buccal cells, saliva and tumor blocks, from study participants and/or diagnosing hospitals including KCI and non-KCI facilities. Collection from KCI facilities is coordinated with the Biorepository Core. Database Query. Response to requests for population-based data requiring query of the MDCSS and/or the national SEER Limited-Use data files and SEER-Medicare files for descriptive analyses. Database Linkage. Linkage of outside data sources to MDCSS data for the collection of patient demographics, treatment and survival data.

4100 John R Detroit, Michigan 48201The Behavioral and Field Research Core (BFRC) is designed to facilitate the integration of communication and behavioral research across KCI’s Programs, including studies involving epidemiology, cancer prevention, clinical and developmental therapeutics, palliative care, and genetics. The Core translates research findings from the behavioral sciences into formats that are useful to investigators trying to understand the impact of human behavior on the clinical or research problem at hand. Core Services Available Project Design Consultation Project Management Operations

4100 John R Detroit, Michigan, 48201 United StatesThe Behavioral and Field Research Core (BFRC) is designed to facilitate the integration of communication and behavioral research across KCI’s Programs, including studies involving epidemiology, cancer prevention, clinical and developmental therapeutics, palliative care, and genetics. The Core translates research findings from the behavioral sciences into formats that are useful to investigators trying to understand the impact of human behavior on the clinical or research problem at hand. Core Services Available Project Design Consultation Project Management Operations

275 East HancockWayne State University School of Medicine Center for Molecular Medicine and Genetics (Finley Lab) provides high throughput cloning, yeast and E. coli screening services.

Kalamazoo, MI, 49008-5200 United StatesWestern Michigan University is a national research university enrolling nearly 24,000 students from across the United States and 100 other countries. Founded in 1903, it is a learner-centered, discovery-driven and globally engaged public university that stands out among America’s more than 4,600 higher education institutions.

275 East HancockWayne State University School of Medicine Immunology and Microbiology Department focuses on research for viral infections, bacterial infections, and autoimmune diseases.

3301 Sutton Road Adrian, MI 49221-9397 United StatesWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

Rm 1525-1527, Wing A,Wincon Theracells Biotechnologies provides disease modeling, immunohistochemistry, histological analysis, and microscopic imaging services.

45145 W. 12 Mile Road United States Novi, MICHIGAN, 48377 United StatesXperiential is in an independent analytical testing laboratory based in Novi Michigan. We take on chemical analysis problems from the routine to the most complex. Our state-of-the-art instrument portfolio, coupled with the vast expertise of our scientists and technicians, means we bring value-added consultant services to solve product and process challenges. Let us know what analytical services you need. If for any reason we cannot perform the required services, we will try to recommend another laboratory to contact. We will always do our best to help. That’s our “No Xceptions” customer promise.

18655 Krause Street Riverview, Michigan 48193 USAAsh Stevens offers comprehensive small-molecule drug substance development and cGMP manufacturing services.

Riverview, MI United StatesAsh Stevens offers comprehensive small-molecule drug substance development and cGMP manufacturing services.

24350 Indoplex, Farmington Hills, MI 48335

1514 Eisenhower Place Ann Arbor, MI 48108-3284, USAArbor Assays builds the highest quality detection and immunoassay products for clinically important biomolecules. We build robust immunoassay and enzyme activity kits to quantitate biomolecules in biological matrices, provide custom assay testing services, and offer world-class customer support.

1514 Eisenhower Pl. Ann Arbor, Michigan, 48108 United StatesArbor Assays builds the highest quality detection and immunoassay products for clinically important biomolecules. We build robust immunoassay and enzyme activity kits to quantitate biomolecules in biological matrices, provide custom assay testing services, and offer world-class customer support.

2255 S. Industrial Hwy. Ann Arbor MI 48104 USA

459 Hughes Drive Traverse City, MI 49686Accutest Research Laboratories offers clinical trials, method development, pharmacokinetic analysis, BA/BE studies, and herbal medicine screening.

6859 Quality Way Portage, MI 49002Eurofins AvTech Labs offers a range of analytical and bioanalytical services including in vitro ADME assays, in vivo PK, bioanalysis, immunoassay development and biomarker ID and GMP method development.

574 South Wagner Road Suite 5 Ann Arbor , MI, 48103 United StatesA2IDEA, LLC is a computational biology and bioinformatics contract research organization. We fill the needs of individual researchers in cost-effective, customized analyses within rapid timeframes. We’re a diverse group of researchers. There is no hierarchy to our company. We all do our individual part to ensure our customers gain the insights they need in their data in combination with public data. Our co-founders have Ph.D.’s in the following fields: Cancer Pharmacology, Genetics, Bioinformatics, Computational Physics, and Computer Science. Most of us have been in the lab generating diverse high-throughput data. These experiences allow us to bring even more expertise to the bioinformatic tools we construct and use. But even more important is our motivation. We want to help biomedical researchers obtain, analyze, and summarize big ‘omics’ data. We strive to help researchers visualize, discover and develop the next cancer therapeutic. We expect to always provide customized analyses based on the individual research question. A2IDEA, LLC prides itself on listening intently to the customer research questions, providing accurate analyses and delivering reproducible research that is easily understood to non-bioinformaticians.

4840 Venture Drive United States Ann Arbor, MI, 48108 United StatesAvomeen Analytical Services - Advanced Product Testing & Formulation Development: Avomeen’s fully integrated pharmaceutical product development laboratory is FDA-registered, DEA-Licensed (Schedule I-V), cGMP-Compliant, and ISO/IEC 17025-Accredited. Two-Thirds of our staff are Ph.D. chemists who work from our state-of-the-art facility and specialize at solving the complex problems that arise during the drug development process. Avomeen offers a wide range of services for pharmaceutical manufacturing and drug development companies. Our services include API, excipient, contaminant, and drug product testing as well as formulation, process development and drug product manufacturing. From developing and validating complicated methods, producing clinical supplies, to the identification of a complex degradation product, our experienced team can solve your complex pharmaceutical problem. Industries Served: Pharmaceuticals/Supplements Consumer Products Polymers/Plastics Paints/Coatings Cosmetic & Topical Products

674 S. Wagner Rd Suite 30 Ann Arbor, Michigan, 48103 United StatesAkadeum has created the next generation of cell isolation. Our Buoyancy Activated Cell Separation (BACS™) microbubble technology uses microscopic microbubbles to capture target cells and quickly and gently float them to the surface of a liquid sample for removal. After removal, the significantly cleaned up sample of highly pure cells can be used to perform downstream testing and analysis, such as PCR, flow cytometry, and cell culture. Ready to elevate your research?! Please check out our portfolio of ready-to-use kits: Red Blood Cell Depletion T Cell Isolation B Cell Isolation Streptavidin Products At Akadeum, we strive to disrupt the status quo user experience to improve your workflow. In parallel, the company is also establishing business-to-business partnerships for applications in diagnostics, cell therapy, and bioprocessing. Should you wish to consider a partnership with Akadeum, please reach out to info@akadeum.com. *Discount does not apply to fees. Offer valid on orders placed through May 31, 2021. Discounts are only valid in the United States. Other conditions or restrictions may apply.