21 Drydock Ave Ste 750E Boston, Massachusetts, 02210-4511 United StatesOperating as Absolute Antibody (Concierge message 20230109)

204 Second Avenue Waltham, MA, 02451 United StatesKyinno Biotechnology is a preclinical contract research operation (CRO) dedicated to oncology drug discovery service and customized product development, with a focus on immuno-oncology and next-generation kinase inhibitor discovery. Our strength is the strong R&D team with decades of experience in the pharmaceutical and biotechnology industry in the United States. We have comprehensive development capability to construct stable cell lines engineered in unique and new targets through CRISPR Knock-in/Knock-out technology. Our animal facilities with a capacity of 1,000 cages (5,000 mice)are located in Beijing. We can perform 60 projects at the same time. Our service platforms include: 1. Off-the-shelf stable cell lines More than 3000 engineered cell lines are available (in stock) in our Waltham logistic center (MA, United States). The lead time will be 2~3 business days in the United States and about 2 weeks in Europe. 2. Custom cell line engineering Background cell lines. Over 700 human tumor cells and other animal cells are available for engineering. Technology. CRISPR Knock-in/Knock-out technology (homozygous clone and heterozygous clone) for site-specific integration. Overexpress gene/target using lentivirus vector transfection Standard deliver pool/single clone with validated PCR sequencing/Mycoplasma free/STR/HiBit test/Western Blot (WB) validation/siRNA test. 2. Cell-based assay validation and drug screening(small molecule compound and PROTACs) Cell proliferation assay(cell cytotoxicity assay).3D cell proliferation assay and 2D cell proliferation assay FACS binding assay/FACS internalization assay/ Immunol pathway assay/ ELISA assay ADCC cell-based bioassays/antibody-dependent cellular phagocytosis (ADCP) assays 3. Drug combination (in vivo combination and in vitro combination) integrated with bioinformatics analysis. 4. Pharmacology in vitro and in vivo study service, PK/PD efficacy studies in our ideal immunodeficient models. Hundreds of cell line-derived xenograft (CDX) mouse models are validated and are ready to test new anti-cancer drugs. BaF3 xenograft models Syngeneic models PBMC humanized mouse model Luciferase tumor model IVIS Imaging/Whole blood, spleen, and lymph node analysis/Chemotherapy validation 4. Phage display library and hybridoma technology for antibody drug discovery Humanization and affinity maturation Draggability and immunogenicity evaluation Nanobody Hybridoma services Single B cell sequencing 5. Common light chain technology 6. Cancer cell panel compound profiling and biomarker discovery 7. Mega screening platform HRD Homologous recombination deficiency (HRD) score of the cell lines was calculated and 100 cell lines with high HRD scores were selected for compound screening. Kinase BaF3 cell panel screening. With our gene-editing expertise, KYINNO has constructed over 700 BaF3 cell lines which harbor various hotspot kinase drug targets. Our dedicated cell-based assay team daily handles hundreds of BaF3 cell lines and thousands of test articles. Most of the engineered BaF3 cell lines are suitable for in vivo efficacy studies. By in vitro screening, the compounds showing good potency can be quickly selected for further in vivo efficacy study without any delay in our one-stop service. Target: EGFR family, VEGFR family, FGFR family, EML4, ALK, NTRK family, FLT3 family, ROS1, HER2, HER3, BCR-ABL, cKit, RET, TAM family, KRAS, NRAS, HRAS, IGF1R, TPR-Met, etc. Innovative membrane proteins screening array MPSA-AB5000 The specificity of antibodies, CAR-T cells, and other biologic therapeutics to their binding targets is an important step in the evaluation process of drug development. MPSA-AB5000 is a high-throughput cell-based platform for identifying the targets of antibodies and other ligands that bind to human membrane proteins for determining the specificity and preclinical safety of antibodies, CAR-T cell therapies, ADC, and other biotherapeutics. Here are some key features and benefits of AB5000: Unparalleled Antibody Specificity Screening. Our advanced platform allows for screening a wide range of human membrane proteins, which are critical for accurate specificity assessment. Early Off-Target Screening. The largest collection of human membrane proteins is natively expressed in live cells. You can conveniently determine the specificity and preclinical safety of biotherapeutics. Rapid, Simple, and Highly Sensitive. This cutting-edge technology provides rapid, simple, and highly sensitive results by measuring binding through ADCC via a luciferase reporter cell line. The wash-free strategy reduces false negatives, and signal amplification makes remarkable discrimination. Comprehensive Preclinical Safety Assessment. Our products catalogs: Kinase cell line Immune molecule cell line Gene Editing Cell line Engineered reporter cell lines Luciferase cell line Fluorescence-labeled cell line Drug-resistant cell line Antibody and proteins with fully validated functions in reporter cell lines Isotype control Therapeutic antibody Hybridoma Recombinant protein

204 SECOND AVE WALTHAM, Massachusetts, 02451-1126 United StatesKyinno Biotechnology is a preclinical contract research operation (CRO) dedicated to oncology drug discovery service and customized product development, with a focus on immuno-oncology and next-generation kinase inhibitor discovery. Our strength is the strong R&D team with decades of experience in the pharmaceutical and biotechnology industry in the United States. We have comprehensive development capability to construct stable cell lines engineered in unique and new targets through CRISPR Knock-in/Knock-out technology. Our animal facilities with a capacity of 1,000 cages (5,000 mice)are located in Beijing. We can perform 60 projects at the same time. Our service platforms include: 1. Off-the-shelf stable cell lines More than 3000 engineered cell lines are available (in stock) in our Waltham logistic center (MA, United States). The lead time will be 2~3 business days in the United States and about 2 weeks in Europe. 2. Custom cell line engineering Background cell lines. Over 700 human tumor cells and other animal cells are available for engineering. Technology. CRISPR Knock-in/Knock-out technology (homozygous clone and heterozygous clone) for site-specific integration. Overexpress gene/target using lentivirus vector transfection Standard deliver pool/single clone with validated PCR sequencing/Mycoplasma free/STR/HiBit test/Western Blot (WB) validation/siRNA test. 2. Cell-based assay validation and drug screening(small molecule compound and PROTACs) Cell proliferation assay(cell cytotoxicity assay).3D cell proliferation assay and 2D cell proliferation assay FACS binding assay/FACS internalization assay/ Immunol pathway assay/ ELISA assay ADCC cell-based bioassays/antibody-dependent cellular phagocytosis (ADCP) assays 3. Drug combination (in vivo combination and in vitro combination) integrated with bioinformatics analysis. 4. Pharmacology in vitro and in vivo study service, PK/PD efficacy studies in our ideal immunodeficient models. Hundreds of cell line-derived xenograft (CDX) mouse models are validated and are ready to test new anti-cancer drugs. BaF3 xenograft models Syngeneic models PBMC humanized mouse model Luciferase tumor model IVIS Imaging/Whole blood, spleen, and lymph node analysis/Chemotherapy validation 4. Phage display library and hybridoma technology for antibody drug discovery Humanization and affinity maturation Draggability and immunogenicity evaluation Nanobody Hybridoma services Single B cell sequencing 5. Common light chain technology 6. Cancer cell panel compound profiling and biomarker discovery 7. Mega screening platform HRD Homologous recombination deficiency (HRD) score of the cell lines was calculated and 100 cell lines with high HRD scores were selected for compound screening. Kinase BaF3 cell panel screening. With our gene-editing expertise, KYINNO has constructed over 700 BaF3 cell lines which harbor various hotspot kinase drug targets. Our dedicated cell-based assay team daily handles hundreds of BaF3 cell lines and thousands of test articles. Most of the engineered BaF3 cell lines are suitable for in vivo efficacy studies. By in vitro screening, the compounds showing good potency can be quickly selected for further in vivo efficacy study without any delay in our one-stop service. Target: EGFR family, VEGFR family, FGFR family, EML4, ALK, NTRK family, FLT3 family, ROS1, HER2, HER3, BCR-ABL, cKit, RET, TAM family, KRAS, NRAS, HRAS, IGF1R, TPR-Met, etc. Innovative membrane proteins screening array MPSA-AB5000 The specificity of antibodies, CAR-T cells, and other biologic therapeutics to their binding targets is an important step in the evaluation process of drug development. MPSA-AB5000 is a high-throughput cell-based platform for identifying the targets of antibodies and other ligands that bind to human membrane proteins for determining the specificity and preclinical safety of antibodies, CAR-T cell therapies, ADC, and other biotherapeutics. Here are some key features and benefits of AB5000: Unparalleled Antibody Specificity Screening. Our advanced platform allows for screening a wide range of human membrane proteins, which are critical for accurate specificity assessment. Early Off-Target Screening. The largest collection of human membrane proteins is natively expressed in live cells. You can conveniently determine the specificity and preclinical safety of biotherapeutics. Rapid, Simple, and Highly Sensitive. This cutting-edge technology provides rapid, simple, and highly sensitive results by measuring binding through ADCC via a luciferase reporter cell line. The wash-free strategy reduces false negatives, and signal amplification makes remarkable discrimination. Comprehensive Preclinical Safety Assessment. Our products catalogs: Kinase cell line Immune molecule cell line Gene Editing Cell line Engineered reporter cell lines Luciferase cell line Fluorescence-labeled cell line Drug-resistant cell line Antibody and proteins with fully validated functions in reporter cell lines Isotype control Therapeutic antibody Hybridoma Recombinant protein

Framingham, MA United StatesAmerican International Chemical provides specialty ingredients and diagnostic research services.

One Water Street, Suite A Haverhill, MA 01830 USAActivMed Practices and Research offers clinical research services.

Haverhill, MA United StatesActivMed Practices and Research offers clinical research services.

3 Ave, C Hopkinton, MA 01748 USAAlkras LLC is the OEM CO2 laser company. It offers CO2 lasers of Series AL from 700 to 2500 watts of output power with different modes and wavelengths. The simplicity of technological power developed by Alexander V. Krasnov gives significant cost reduction of lasers compared to any other well-known laser company in the world. The advantages of this technology also include its compact size, efficiency, economical operations, and ease of maintenance. This technology provides a better choice for the consumer to invest their money wisely.

Burlington, MA United States

Worcester, MA United StatesAntigen Targeting Consulting Service provide antibody, immonhistochemistry, ELISA, and amplification services.

1 Innovation Drive Worcester, MA 01605Antigen Targeting Consulting Service provide antibody, immonhistochemistry, ELISA, and amplification services.

225 Turnpike Road Southborough MA 01772Averion International offers clinical trials, trial design, site selection, medical writing, and clinical analysis.

85 Pine Grove St. Needham, MA 02494 USAAbazyme supplies antibodies, conjugates, enzymes, ELISA kits, and cytokines in addition to offering custom antibody and DNA services.

1 Executive Park Drive Newton, MA, 02462 United StatesAllena Pharmaceuticals is developing and commercializing non-systemic protein therapeutics to treat metabolic and orphan diseases, with a particular focus on nephrologic and urologic conditions.

Cambridge, MA United StatesAddgene is a non-profit plasmid repository. We archive and distribute high quality plasmids generated by your colleagues.

One Kendall Sq B7102 Cambridge, MA 02139 USAAddgene is a non-profit plasmid repository. We archive and distribute high quality plasmids generated by your colleagues.

135 Beaver Street Suite 204 Waltham, MA, 02452 United StatesARP American Research Products, Inc is the premier provider for all of your research and diagnostic needs. Based in Massachusetts, ARP has been providing high-quality products to research laboratories in hospitals, universities and biotech firms worldwide since 1994.

489 Common St. Belmont, MA 02478 USAARP American Research Products, Inc is the premier provider for all of your research and diagnostic needs. Based in Massachusetts, ARP has been providing high-quality products to research laboratories in hospitals, universities and biotech firms worldwide since 1994.

185 New Boston Rd Woburn, MA , 01801 United StatesHeadquartered at metro Boston, MA, USA, Aldlab is a leading manufacturer of high quality specialty organic chemicals serving pharmaceutical, biotech and chemical industries all over the world. More than 20 years of synthesis experience enables Aldlab to offer more than 50,000 products, as well as capacity of custom synthesis. If you cannot find a desired compound in our catalog, please send us an inquiry. In addition, Aldlab provides more than 2 million products for screening, and many products are uniquely available through us. As a scientist, the quality of research work you do is only as good as the material you use. That’s why where you get chemical reagents is important. If the quality is not what you expert, it can impair your research, costing your considerable time and money, as well as delay. We kept excellent production records. In past several years, we have completed more than 10000 custom synthesis projects, from mg to bulk scale, with timely delivery. Aldlab has established a manufacture site in Shanghai China for the bulk production, which has been certified with ISO 9001:2008 since 2013. Both of our R&D and manufacture sites have passed several audits from large pharmaceutical companies of Europe and USA. Aldlab has US-based customer service. Our main office, warehouse and research center is located in Boston, MA. Our knowledgeable professional sales team (most of them are chemists from bachelor to Ph.D, they speak the same “language” as you) are ready to provide fast and professional service to our customer. Please contact us when you require: * Compounds those are not listed in our catalog. * A large volume of our products * Manufacturing for your developed products using similar reaction or new synthesis routes * Developing new methods to improve the yield Aldlab philosophy is to enrich people’s better lives by contributing to the advancement of science. Our mission is to meet the needs of research fields in a timely manner by discovering and providing a wide variety of unique chemical reagents. Aldlab moves your science work forward.

35 Flagship Dr. North Andover, Massachusetts, 01845 United StatesAsisChem offers custom synthesis, medicinal chemistry, drug discovery, scale up, process optimization, technology development & tech transfer. AsisChem serves the pharmaceutical and biotechnology industries, academic and industrial laboratories, in the area of new drug research and discovery. We help make the drug discovery process more efficient and cost effective while focusing on quality and reliability.

245 First Street, 18th Floor Cambridge MA 02142 United StatesAsisChem offers custom synthesis, medicinal chemistry, drug discovery, scale up, process optimization, technology development & tech transfer. AsisChem serves the pharmaceutical and biotechnology industries, academic and industrial laboratories, in the area of new drug research and discovery. We help make the drug discovery process more efficient and cost effective while focusing on quality and reliability.

104 Gold Street Agawam, MA 01001High accuracy microbiology, virology and analytical chemistry testing translates into greater product development and manufacturing efficiency, optimizing safety for your product users. You need accurate results-and an accurate understanding of those results-to move your project and what else you should consider moving forward. That’s exactly the kind of service you’ll find when you partner with Accuratus Labs.

91 Hartwell Ave # 1 Lexington, MA 02421-3130 USAAptuit Consulting provides consulting for drug development, nonclinical development, CMC, regulatory affairs, and clinical programs.

4 Hartwell Sreet First Floor, Suite #2 Fall River, MA 02721AccelRx provides clinical research trials for products relating to cognitive function and depression.

281 Albany Street Cambridge, MA, 02139 United StatesAileron Therapeutics, based in Cambridge, Massachusetts, is a biopharmaceutical company developing and advancing a revolutionary class of drugs called Stapled Peptides.

26 Pemberton Rd. Wayland, MA 01778Avaxia Biologics focuses on the development of therapeutic antibodies for oral mucositis, obesity, diabetes, inflammatory bowel disease, and celiac disease.

232 Pond Street Natick, MA, 01760 United StatesAnalgesic Solutions is a hands on team of experts who consult on and conduct clinical trials in the process of bringing pain treatments to market. With hundreds of projects completed and ongoing collaborations with regulatory authorities, Analgesic Solutions is the premier choice for providing assistance and implementation tools for successful pain trials. Mistakes are costly and often you only get one shot at success. Clients come to us when looking to develop and commercialize better treatments for pain. Our team, with Dr. Nathaniel Katz serving as our foremost expert, helps our clients bring their pain solutions to commercial reality.

3G Gill Street Woburn WA 01801 USAAnthill Technologies provides automated high-throughput organic synthesis, chemical development and scale-up, chemical and process engineering.

25 John Road, Canton, 02021 MA, USAArmstrong Pharmaceuticals manufactures specialty aerosol products from a wide array of topical, personal care, and pharmaceutical products.

455 Fortune Blvd Suite 2 Milford, MA, 01757 United StatesAverica Discovery Services, Inc. is an analytical development contract research organization (CRO) with specialized expertise in small molecule analysis and purification. We work with chemistry-driven discovery and development teams to speed drug candidate selection and shorten timelines into early development. Averica was founded in 2007 as a source of chromatography expertise, with a leadership team having extensive experience in pharmaceutical R&D. We began using Supercritical Fluid Chromatography (SFC) technology in chiral and achiral separations, and have expanded to become a provider of a wide variety of chromatography and analytical services. These services include scalable small molecule purification, isolation and identification of impurities, and custom analytical development work. Acquired by Neopharm Labs Inc. in late 2016, Averica is the US laboratory and sales office for its Quebec-based parent. Serving the Life Science industry for 25 years, Neopharm is a full service GMP analytical testing laboratory closely collaborating with pharmaceutical, medical device, natural health, veterinary, and cosmetic clients.

1 Devonshire Place Boston, MA, 02109 United StatesaktaPD is headquartered in Boston with a US office in Raleigh, NC and worldwide branches in Sweden, Canada, and Germany. We are a Life Science industry partner to clients developing new chemical/molecular entities (NCEs/NMEs), biosimilars, biologics, diagnostics, and devices that provides expertise in all facets and phases of product development. aktaPD’s solutions will allow you to expedite the idea to market path by increasing revenue, enhancing quality, assisting with decision-making, shortening timelines, increasing productivity, and decreasing costs.

220 South Pleasant Street Amherst, MA 01002Amherst College is one of the premier liberal arts colleges in the nation, enrolling 1,800 talented, energetic and diverse young men and women. Our open curriculum is one of the boldest, most productive experiments in higher education.

Falmouth, MA, 02536 United StatesAssociates of Cape Cod provides endotoxin testing, environmental removal analysis, and training.

704 Main Street Falmouth MA 02540Associates of Cape Cod provides endotoxin testing, environmental removal analysis, and training.

26 Parkridge Rd Ward Hill, MA 01835 USAAlfa Aesar is a leading manufacturer and supplier of research chemicals, metals and materials for a wide span of applications.

100 Main Street Concord, MA, 01742 United StatesAlopexx Enterprises, LLC was founded in 2011 as an outgrowth of a collaboration that led to the successful development and licensing of an early stage pharmaceutical product.

9 Linnell Circle Billerica, MA 01821-3902 United States of AmericaAST Products, Inc. was founded in 1989 to develop novel surface technologies and coatings. Initially a research based organization, AST now offers medical device products and a line of patented and proprietary coatings for the medical device and specialty materials industries. AST also provides specially engineered plasma reactors and analysis equipment that facilitate the application of its advanced coatings. Headquartered in Billerica, MA, USA, AST operates a 23,000 square foot facility fully equipped with Class 10,000 and Class 100,000 cleanrooms, and advanced analytical and research labs. As an ISO 13485:2003 and ISO 9001:2008 registered, Good Manufacturing Practice (GMP) compliant business, AST can offer contract surface treatment services to companies that require the highest degree of quality from their suppliers.

260 W. Cummings Park Woburn, MA 01801 USAAlphaGene creates platforms which produce validated drug targets leading to drug discovery in the field of neurology and oncology.

100 Cummings Center, Suite 438Q Beverly, MA, 01915 United StatesOverview: Adeptrix Corporation is a research reagent company. The company was established to commercialize a new analytical platform technology termed Bead Assisted Mass Spectrometry (BAMS), for multiplexed targeted protein analysis. Our solution: BAMS combines two common technologies: immunoaffinity capture and mass spectrometry detection. Mass spectrometry is currently a low throughput method because it requires extensive upfront sample fractionation by liquid chromatography (LC-MS). BAMS unique platform couples bead-based immunoassays with MALDI mass spectrometry to achieve both high multiplexing and high throughput capacity. BAMS can quantify total protein abundance, protein isoforms, SNPs and post-translationally modified (PTM) sites to perform in-depth proteomic profiling of biological samples.

100 Cummings Center, Suite 451C Beverly, MA, 01915 United StatesOverview: Adeptrix Corporation is a research reagent company. The company was established to commercialize a new analytical platform technology termed Bead Assisted Mass Spectrometry (BAMS), for multiplexed targeted protein analysis. Our solution: BAMS combines two common technologies: immunoaffinity capture and mass spectrometry detection. Mass spectrometry is currently a low throughput method because it requires extensive upfront sample fractionation by liquid chromatography (LC-MS). BAMS unique platform couples bead-based immunoassays with MALDI mass spectrometry to achieve both high multiplexing and high throughput capacity. BAMS can quantify total protein abundance, protein isoforms, SNPs and post-translationally modified (PTM) sites to perform in-depth proteomic profiling of biological samples.

18 Old Colony Dri Dover, MA, 02030 United StatesDisruptive HEOR boutique with analytic tech platform combined with deep scientific bench featuring many senior PhDs. Licensed inhouse national all payer claims data with concierge support services, covers over 80% of all claims in U.S. with only 3-4 week lag and multichannel (commercial and non-commercial, including Medicare and Medicaid). Proprietary analytics tool and capabilities. Platform is data-agnostic across different channels to accommodate rapid analysis of data from disparate sources such as claims, EMR, clinical trials, surveys, etc. Services and in-house capabilities include both US and global full-service research in HEOR, RWE, Market Access and Commercial Analytics

750 Main St, STE 328 Cambridge, Massachusetts, 02139-3544 United StatesWe have a novel proprietary platform that can print amino acids into custom peptide chains of 250-300, with the ability to use non-natural amino acids and to also print in the D form.

1 Broadway Cambridge, MA, 02142 United StatesAntiverse is an AI biotech company engineering the future of drug discovery. We use machine learning to design antibodies against difficult targets such as GPCRs and ion channels.

100 Campus Drive 6th Floor Marlboro, MA, 01752 United StatesAkoya Biosciences’ history represents the rapid advancement driving the field of multiplexed biomarker analysis and immunofluorescence tissue analysis. Today’s Akoya portfolio spans the spectrum from powerful tools for discovery of important biomarkers to clinical research applications. Akoya Biosciences was founded in 2015 to commercialize the CODEX System to enable ultra-high multiplexing for biomarker discovery. The Phenoptics™ technology was originally conceived and developed by Cambridge Research & Instrumentation, acquired by Caliper in 2010, and subsequently acquired by PerkinElmer in 2011. The Phenoptics™ technology was promptly adopted as the industry standard for multiplexed tissue analysis for translational and clinical research. The partnership between PerkinElmer and Telegraph Hill Partners, announced in November of 2018, created the current Akoya Biosciences through the sale of Phenoptics by PerkinElmer and its incorporation into Akoya. This combined portfolio of complementary CODEX and Phenoptics technologies will continue to fuel groundbreaking advancements in cancer immunology, immunotherapy and a wide range of pathology research. Akoya Biosciences currently offers Phenoptics multiplex IHC panel development and sample staining and analysis as a service through its Contract Research Services (CRS) group.

733 Concord Ave Cambridge, Massachusetts, 02138 United StatesAzenta Life Sciences provides unrivaled sample exploration and management solutions to help our customers accelerate discovery, development, and delivery to bring impactful breakthroughs and therapies to market faster. We are the global leader in automated compound management for drug discovery, biological storage, and sample processing solutions. Azenta understands the importance of sample integrity and provides a comprehensive range of solutions across our leading capabilities of genomic services, sample repository services (SRS), consumables and instruments, data management and informatics, sample sourcing, and automated ultra-cold storage.

200 Summit Drive Burlington, MA, 01803 United StatesAzenta Life Sciences provides unrivaled sample exploration and management solutions to help our customers accelerate discovery, development, and delivery to bring impactful breakthroughs and therapies to market faster. We are the global leader in automated compound management for drug discovery, biological storage, and sample processing solutions. Azenta understands the importance of sample integrity and provides a comprehensive range of solutions across our leading capabilities of genomic services, sample repository services (SRS), consumables and instruments, data management and informatics, sample sourcing, and automated ultra-cold storage.

359 Allston Street Cambridge, Massachusetts, 02139 United StatesAvastus CRO offers support through all stages of preclinical research specializing in rat and mouse models. Our team of talented technicians routinely executes model development, tolerability, biodistribution, PK/PD, and efficacy studies in a variety of model systems. We specialize in models of oncology, immune-oncology, autoimmune diseases, rare genetic diseases, metabolic disorders, inflammation, immunization, CNS, breeding, as well as execute surgical models and have access to humanized and GEM models. Avastus prides itself in its collaborative and flexible approach and is committed to letting your science drive your experiments. No request is too small or large and our team is always ready to help however we can. Similarly, Avastus also offers affordable housing and husbandry services and the use of laboratory space to perform experiments at either of our two newly built locations.

320 Putnam Ave, Cambridge, MA 02139Avastus CRO offers support through all stages of preclinical research specializing in rat and mouse models. Our team of talented technicians routinely executes model development, tolerability, biodistribution, PK/PD, and efficacy studies in a variety of model systems. We specialize in models of oncology, immune-oncology, autoimmune diseases, rare genetic diseases, metabolic disorders, inflammation, immunization, CNS, breeding, as well as execute surgical models and have access to humanized and GEM models. Avastus prides itself in its collaborative and flexible approach and is committed to letting your science drive your experiments. No request is too small or large and our team is always ready to help however we can. Similarly, Avastus also offers affordable housing and husbandry services and the use of laboratory space to perform experiments at either of our two newly built locations.

320 Putnam Avenue Cambridge, MA, 02139 United StatesAvastus CRO offers support through all stages of preclinical research specializing in rat and mouse models. Our team of talented technicians routinely executes model development, tolerability, biodistribution, PK/PD, and efficacy studies in a variety of model systems. We specialize in models of oncology, immune-oncology, autoimmune diseases, rare genetic diseases, metabolic disorders, inflammation, immunization, CNS, breeding, as well as execute surgical models and have access to humanized and GEM models. Avastus prides itself in its collaborative and flexible approach and is committed to letting your science drive your experiments. No request is too small or large and our team is always ready to help however we can. Similarly, Avastus also offers affordable housing and husbandry services and the use of laboratory space to perform experiments at either of our two newly built locations.

42-44 Spinelli Place Cambridge , MA, 02138 United StatesAvastus CRO offers support through all stages of preclinical research specializing in rat and mouse models. Our team of talented technicians routinely executes model development, tolerability, biodistribution, PK/PD, and efficacy studies in a variety of model systems. We specialize in models of oncology, immune-oncology, autoimmune diseases, rare genetic diseases, metabolic disorders, inflammation, immunization, CNS, breeding, as well as execute surgical models and have access to humanized and GEM models. Avastus prides itself in its collaborative and flexible approach and is committed to letting your science drive your experiments. No request is too small or large and our team is always ready to help however we can. Similarly, Avastus also offers affordable housing and husbandry services and the use of laboratory space to perform experiments at either of our two newly built locations.

57 Smith Place Cambridge, MA, 02138 United StatesAvastus CRO offers support through all stages of preclinical research specializing in rat and mouse models. Our team of talented technicians routinely executes model development, tolerability, biodistribution, PK/PD, and efficacy studies in a variety of model systems. We specialize in models of oncology, immune-oncology, autoimmune diseases, rare genetic diseases, metabolic disorders, inflammation, immunization, CNS, breeding, as well as execute surgical models and have access to humanized and GEM models. Avastus prides itself in its collaborative and flexible approach and is committed to letting your science drive your experiments. No request is too small or large and our team is always ready to help however we can. Similarly, Avastus also offers affordable housing and husbandry services and the use of laboratory space to perform experiments at either of our two newly built locations.

222 Maple Avenue Rose Gordon Building, Suite 224 Shrewsbury, MA, 01545 United StatesOur mission is to deliver top-quality histology and pathology services that cater to the needs of both industrial and academic laboratories. Our extensive range of capabilities includes general histology, H&E stains, various special chemical stains, IHC stains, antibody validation, multiplexed IF stains, digital imaging, whole slide scanning, and pathology evaluation/scoring for different diseases or disease models. We are a CLIA-certified laboratory, and our anatomic pathology services are available to clinics and hospitals, as well as clinical trial studies.

P.O. Box 301179 Boston, MA, 02130 United StatesAsymmetrex is a life sciences biotechnology company with a focus on innovating technologies that will advance the potential of perinatal and postnatal tissue stem cells into routine medical practice. Tissue stem cells are found in the bodies of children and adults. They are a minute fraction of the cells (less than 1 per 1000) that make up organs and tissues like the liver, cornea, skin, muscles, hair, brain, bone marrow, and umbilical cord blood. Despite their small fraction, they are responsible for continuously renewing and repairing the body. A long-standing challenge in stem cell biomedicine has been the lack of a means to count tissue stem cells specifically and determine their specific dose for stem cell transplantation therapies. Because tissue stem cells are a minor fraction of tissue cells, even in the best enriched populations, and there are no known biomarkers that recognize tissue stem cells specifically, previously it has not been possible to count therapeutic tissue stem cells. Asymmetrex now offers the AlphaSTEM Test^TM for this purpose. Asymmetrex's AlphaSTEM Test^TM is the first and only technology that provides specific and accurate counting of any human tissue stem cell in complex tissue cell preparations. It can be used to determine the dose of therapeutic tissue stem cells like hematopoietic stem cells and mesenchymal stem cells. It can be use to monitor and optimize tissue stem cell number in manufacturing processes. It can be used to identify agents that affect tissue stem cell function and viability either positively or negatively. In the latter case, the AlphaSTEM Test^TM provides the unique advantage of earlier identification of drug candidates that will fail later in clinical trials or post-marketing because of causing chronic organ failure (e.g., bone marrow or hepatic). This is possible because of the test's ability to detect stem cell-specific toxicity in primary cell cultures of any proliferative human tissue. Tissue stem cell toxicity is a major cause of chronic organ failure by drug candidates.

500 West Boylston Street United States Worcester, Massachusetts, 01606 United StatesAccelerating Translational Research (ATR) offers assay development services in immunology and in vitro pharmacology, including flow cytometry- and ELISA-based assays, cell culture, PK/PD, immunogenicity, antibody phenotyping, screening and efficacy assays, complement assays, kit testing and validation.

500 West Boylston Street, Worcester, MA 01606, USAccelerating Translational Research (ATR) offers assay development services in immunology and in vitro pharmacology, including flow cytometry- and ELISA-based assays, cell culture, PK/PD, immunogenicity, antibody phenotyping, screening and efficacy assays, complement assays, kit testing and validation.

500 West Boylston Street, Worcester, MA 01606, USAccelerating Translational Research (ATR) offers assay development services in immunology and in vitro pharmacology, including flow cytometry- and ELISA-based assays, cell culture, PK/PD, immunogenicity, antibody phenotyping, screening and efficacy assays, complement assays, kit testing and validation.

607 Boylston Street, Suite 384 Boston, MA, 02116 United StatesAlphabioregen is a regenerative medicine-based biotechnology company, which is specialized in providing latest and unique approaches for 3D technologies in tissue culture

200 Westboro Road 201 Westboro Road Grafton, MA, 01536 United StatesBetter human disease models: We use iPSCs to build more relevant models of human disease to expand your understanding and de risk drug development: - Specialist human iPSC CRO - Supporting neurodegenerative / neuroinflammatory drug discovery - Extensive library of donor iPSCs including lines from Alzheimers, ALS, FTD, Parkinsons, Huntingtons - Full services from donor sourcing, line reprogramming, differentiation, end assays and compound screening - Advanced human like models for pre-clinical research and classification At Axol Bioscience, we support your pursuit of more effective, safer therapies. Like you, we believe that having more human relevant disease models will expand scientific knowledge and de risk drug development. We use human iPSCs to achieve this and have been doing so since 2006. We use donated cells from patients and iPSC technology to build physiologically relevant in vitro models. We have a special focus on neurodegenerative diseases like Alzheimer’s disease as well as cardiotoxicity to promote drug safety. When working with candidate compounds or novel therapies, our in vitro platforms give you better earlier stage modeling and safety testing and later stage efficacy evaluation and improved patient selection. With these data comes better insights, helping you de-risk projects, reduce costs, and save time during drug development. At Axol Bioscience, we help your science with better models of human disease. Since our merger, the company is Censo Biotechnologies trading as Axol Bioscience. All invoices and documentation should be addressed to "Censo Biotechnologies trading as Axol Bioscience."

1250 Hancock Street, Suite 120S Quincy, MA, 02169 United StatesFeatured: - GMP-compliant Leukopaks, GMP Bone Marrow, Mobilized Leukopaks, as well as Cryopreserved Leukopak products - Integrated network of HLA-typed donor pools located across the United States, in accordance with IRB, FDA, and AABB - Extensive research-use products and services & class A and B cleanroom capabilities - Bulk (full pak) cell isolations for cell banking or matched samples pre-clinical screening options for early-stage pipeline development Founded in 1998, AllCells is the global leader in the procurement and customization of biologically relevant research and GMP-compliant products and donor management services to support a diversity of life sciences applications. AllCells’ FDA-registered facilities, robust quality framework and proven industry expertise afford the responsiveness, product diversity, quality and regulatory standards required by researchers in life sciences. Our donor facilities - located in California, Massachusetts, Alabama, and Texas - and GMP-compliant cleanroom are strategically located, enabling immediate processing and cryopreservation for unparalleled quality. AllCells provides flexible and scalable solutions to support dynamic, client-specific needs and timelines from inception to commercialization. AllCells – Quality Cells for Quality AllCells also provides Clinical Grade products for further manufacturing of allogeneic cell based therapies. Through our experience in GMP Allogeneic Clinical Grade collections, we have developed a proven approach to delivering the highest level of quality and compliance.

57 Union Street Worcester, MA, 01608 United StatesBiomere is a leading provider of preclinical discovery services specializing in a wide range of therapeutic areas in small and large animals including awake animal MRI (Ekam Imaging). Our commitment is to provide our clients with a level of scientific expertise, quality and customer service unmatched in the industry. Nonclinical capabilities include: pharmacokinetics, lead compound screening, proof of concept, efficacy assessment, pharmacology, mechanism of action, and early lead optimization. Biomere also provides supportive colony maintenance, backup colony support and on site room use agreements.

72 E. Concord St., Room 901 Boston, MA 02118 USABoston University Medical Center Flow Cytometry Core Facility offers flow cytometry and cell sorting services as well as expert consultation for project/experiment planning.

Boston, MA United StatesBoston University Medical Center Flow Cytometry Core Facility offers flow cytometry and cell sorting services as well as expert consultation for project/experiment planning.

330 Brookline Avenue Beth Israel Deaconess Medical Center SL232-The Slosberg Building Boston, MA 02215Equipment Agilent 2200 TapeStation System Covaris E220 Ultra-Sonicator Arcturus XT Laser Capture Microdissection System 7000 Real-Time PCR System 7500 Fast Real-Time PCR System Li-Cor Odyssey System Infrared Imager Services On an hourly fee basis the Core provides: Training on equipment usage- RT-PCR Systems, ArcturusXT, CovarisE220 ArcturusXT LCM usage Consultations on Real-Time PCR Technology and Experimental design Core setup of Real-Time PCR runs Probe/primer design Data analysis Troubleshooting On per sample or per run fee basis the core provides: Real-Time PCR runs Quality and Quantity DNA/RNA sample Bio-analysis Covaris Ultrasonicator sample Shearing Odyssey Infrared Imaging

Simon C. Fireman Research North Building 3rd floor, Room 380E, 99 Brookline Ave, Boston, MA 02115The analysis of high-throughput genomics, proteomics, metabolomics and epigenomics data is the most critical step in systematically understanding pathophysiology of a disease as well as identifying potential biomarkers. The analysis of OMICS data often presents a challenge to translational and basic science researchers. The mission of Bioinformatics and Systems Biology core is to provide expertise and infrastructure in designing, analyses and simulation of high-throughput OMICS data to answer underlying biological questions. The core support analysis of data from many next-generation sequencing assays including transcriptional quantification (RNA-Seq), protein-nucleic acid interactions (ChIP-Seq), global methylation, genotyping or variant analysis through genome sequencing. To support cutting edge research, a special emphasis was made on implementing/developing systems biology frameworks and models for integrative analysis of genomic, epigenomics proteomic, metabolomic, imaging and clinical data to identifying key molecules driving pathophysiology. In addition to analyses support, core also provides resources for data management and high performance computing.

378 Page Street, Stoughton, MA 02072, USABiomedical Technologies (BTI) manufactures life science research products.

3, Blackfan Circle 3rd Floor, room 3068 Boston, MA 02115Our mission is to help physicians treat their patients by bridging science and medicine. To accomplish this objective, we support bench-to-bedside and bedside-to-bench translational and clinical research. We operate in two major areas: Laboratory assays for investigator-initiated clinical and translational trials Process and product development (PPD) of assays and biological reagents to support clinical trials. The TransLab builds on a decade of experience and expertise in clinical trial support, initially as part of the Center for Human Cell Therapy. The laboratory moved to Boston Children's Hospital in 2012. The work performed in the TransLab is SOP-driven, quality and regulatory compliant and properly documented.

3 Preston Court Bedford, MA 01730 781-652-4000Our mission is to provide world class Gene-To-Function services. Our proven teams of drug discovery professionals are passionate about unlocking the therapeutic potential of both genetically- and clinically-validated drug targets, and in developing new therapeutic modalities. We work in partnership with our clients to address the most difficult scientific and business challenges facing drug discovery, and to ultimately enable transformational health care outcomes.

3 Preston Ct United States Bedford, Massachusetts, 01730 United StatesOur mission is to provide world class Gene-To-Function services. Our proven teams of drug discovery professionals are passionate about unlocking the therapeutic potential of both genetically- and clinically-validated drug targets, and in developing new therapeutic modalities. We work in partnership with our clients to address the most difficult scientific and business challenges facing drug discovery, and to ultimately enable transformational health care outcomes.

Middleborough, MA United StatesBrookfield Engineering Laboratories provides viscosity measurement and control equipment and services.

24 Balfoul St Lexington, MA 02421 USABIOTANG is a global full-line distributor of high quality biochemicals, reagents and disposable lab research products, and benchtop equipment for Life Sciences.

GZ 8th Floor 330 Brookline Ave. Boston, MA 02115 CLINICAL RESEARCH COORDINATOR CORE SmallerLarger Clinical Research Coordinator Core Core Summary Partially funded through Harvard Catalyst, the Clinical Research Coordinator Core is available to support and collaborate with investigators and their research teams in all phases of clinical research, providing services that include assisting with the organization, implementation and completion of clinical research studies.

310 North Main Street Unit 6, Mansfield, MA 02048 USABiologics Consulting Group, Inc. (BCG) provides regulatory and product development advice on production of biological, drug and device products.

90 Canal Street Boston, MA, 02114 United StatesBISC Global is a fast growing company active in Bioinformatics and Statistics Consulting. In recent years, the major challenges in biotechnological research have shifted away from generating data and more towards data analysis. It is our goal to address these changing needs and build bridges between the worlds of biology and informatics, mathematics and engineering, young professionals and established experts. (www.biscglobal.com) Recently BISC has been acquired by Excelra, creating an international bioinformatics powerhouse with an industry-leading platform and service offering. (Press release) Excelra is a trusted partner to the world’s top pharmaceutical and biotechnology companies, providing data, insight, and R&D technology services. Its interdisciplinary teams of biocurators, bioinformaticians, data scientists, and engineers deliver harmonized data, optimized analysis pipelines, and advanced applications to accelerate drug discovery and development. (www.excelra.com)

90 Canal St 4th Floor Boston, MA, 02114 United StatesBISC Global is a fast growing company active in Bioinformatics and Statistics Consulting. In recent years, the major challenges in biotechnological research have shifted away from generating data and more towards data analysis. It is our goal to address these changing needs and build bridges between the worlds of biology and informatics, mathematics and engineering, young professionals and established experts. (www.biscglobal.com) Recently BISC has been acquired by Excelra, creating an international bioinformatics powerhouse with an industry-leading platform and service offering. (Press release) Excelra is a trusted partner to the world’s top pharmaceutical and biotechnology companies, providing data, insight, and R&D technology services. Its interdisciplinary teams of biocurators, bioinformaticians, data scientists, and engineers deliver harmonized data, optimized analysis pipelines, and advanced applications to accelerate drug discovery and development. (www.excelra.com)

3 Marshall Drive West Newbury, MA, 01985 United StatesWe design and sell automated lab equipment to Academia, Pharmaceutical, Biotech and Biobank research facilities.

461 Boston Street Topsfield, MA, 01983 United StatesWe design and sell automated lab equipment to Academia, Pharmaceutical, Biotech and Biobank research facilities.

4 Mulliken Way Newburyport, MA, 01950 United StatesWe design and sell automated lab equipment to Academia, Pharmaceutical, Biotech and Biobank research facilities.

360, 2nd Avenue Waltham, Massachusetts, 02451 United StatesBiomodels LLC, a preclinical CRO, specializes in the testing and evaluation of drugs for biotech and pharma companies in a variety of different indications. We provide fast, innovative, and predictive models to assist companies of all sizes in the development of therapeutic measures to combat many disease areas of interest.

360, 2nd Avenue Waltham, Massachusetts, 02451 United StatesBiomodels LLC, a preclinical CRO, specializes in the testing and evaluation of drugs for biotech and pharma companies in a variety of different indications. We provide fast, innovative, and predictive models to assist companies of all sizes in the development of therapeutic measures to combat many disease areas of interest.

300 3rd Ave FL6 Waltham, MA, 02451 United StatesBiocytogen provides one-stop solutions for next-generation drug development, from target to IND application to the global biomedical communities. Powered by its cutting-edge gene editing technologies and state-of-art animal facility, Biocytogen developed a seamlessly integrated platform for efficient antibody drug discovery. The technical teams in Biocytogen support a comprehensive portfolio of products and services, covering in vivo/in vitro preclinical services, animal model generation, fully human antibody (via RenMab™ Mouse), therapeutic antibody discovery services, CMC/CDMO, and regulatory affairs support. Biocytogen collaborates with more than 70% of top 50 pharmaceutical and numerous biotech start-up companies worldwide. Together, we discover innovative medicines for a better, healthier world.

50C Audubon Road Wakefield, MA, 01880 United StatesBiocytogen provides one-stop solutions for next-generation drug development, from target to IND application to the global biomedical communities. Powered by its cutting-edge gene editing technologies and state-of-art animal facility, Biocytogen developed a seamlessly integrated platform for efficient antibody drug discovery. The technical teams in Biocytogen support a comprehensive portfolio of products and services, covering in vivo/in vitro preclinical services, animal model generation, fully human antibody (via RenMab™ Mouse), therapeutic antibody discovery services, CMC/CDMO, and regulatory affairs support. Biocytogen collaborates with more than 70% of top 50 pharmaceutical and numerous biotech start-up companies worldwide. Together, we discover innovative medicines for a better, healthier world.

300 Boston Scientific Way Marlborough, MA 01752-1234The Boston Scientific Corporation (abbreviated BSC) is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a range of interventional medical specialties, including interventional radiology, interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention, electrophysiology, cardiac surgery, vascular surgery, endoscopy, oncology, urology and gynecology. Boston Scientific is primarily known for the development of the Taxus Stent, a drug-eluting stent which is used to open clogged arteries.[3] With the full acquisition of Cameron Health in June 2012, the company also became notable for offering a minimally invasive implantable cardioverter-defibrillator (ICD) which they call the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD).

300 Boston Scientific Way Marlborough, MA, 01752-1234 United StatesThe Boston Scientific Corporation (abbreviated BSC) is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a range of interventional medical specialties, including interventional radiology, interventional cardiology, peripheral interventions, neuromodulation, neurovascular intervention, electrophysiology, cardiac surgery, vascular surgery, endoscopy, oncology, urology and gynecology. Boston Scientific is primarily known for the development of the Taxus Stent, a drug-eluting stent which is used to open clogged arteries.[3] With the full acquisition of Cameron Health in June 2012, the company also became notable for offering a minimally invasive implantable cardioverter-defibrillator (ICD) which they call the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD).

425 Fortune Blvd Milford, MA, 01757 United StatesBoston BioProducts Inc. is a manufacturer and provider of buffers, solutions, media, water, and reagents for life science research and manufacturing. Boston BioProducts supplies various biological buffers and reagents in support of studies in molecular biology, yeast research, immunology, histology, and physiology, bioprocessing, and more.

159 Chestnut St Ashland, MA , 01721 United StatesBoston BioProducts Inc. is a manufacturer and provider of buffers, solutions, media, water, and reagents for life science research and manufacturing. Boston BioProducts supplies various biological buffers and reagents in support of studies in molecular biology, yeast research, immunology, histology, and physiology, bioprocessing, and more.

4 Wellington Street Suite 3 Boston, MA, 02118 United StatesFounded in 2003, Boston Strategic Partners, Inc. is an exclusively healthcare-focused consulting firm with a team of experienced clinical/medical, business, and programming professionals. We take a hands-on approach to maintain quality and value to our clients. Our clients range from Fortune 500 companies to mid-sized organizations to start-ups, venture capital and private equity firms, to government agencies. We serve all life science sectors including pharmaceuticals, biotech, medical devices, clinical diagnostics, and bioinformatics in five practice areas: Business & Clinical Strategy, Health Economics & Outcomes Research, Medical & Technical Communications, Regulatory Strategy and Financial Advisory.

4 Wellington Street Suite 3 Boston, MA, 02118 United StatesFounded in 2003, Boston Strategic Partners, Inc. is an exclusively healthcare-focused consulting firm with a team of experienced clinical/medical, business, and programming professionals. We take a hands-on approach to maintain quality and value to our clients. Our clients range from Fortune 500 companies to mid-sized organizations to start-ups, venture capital and private equity firms, to government agencies. We serve all life science sectors including pharmaceuticals, biotech, medical devices, clinical diagnostics, and bioinformatics in five practice areas: Business & Clinical Strategy, Health Economics & Outcomes Research, Medical & Technical Communications, Regulatory Strategy and Financial Advisory.

PO Box 735 Norwood, MA, 02062 United StatesStandard & Advanced Analyses of NGS Data, RNA-Seq, Pathway, Gene Set Enrichment, SNP, etc. Functional & Computational Omics. Disease & Drug Target Discovery. Precision Medicine.

One Broadway, 14th Floor Cambridge, MA, 02142 United StatesBGI Americas specializes in genomics and proteomics services for research institutes and pharmaceutical companies. Key services are enabled by next-generation sequencing and protein mass spectrometry platforms. The services are offered though BGIA's CAP/CLIA and ISO-certified labs as well as mass spec service center.

One Broadway, 3rd Floor Cambridge, MA, 02142 United StatesBGI Americas specializes in genomics and proteomics services for research institutes and pharmaceutical companies. Key services are enabled by next-generation sequencing and protein mass spectrometry platforms. The services are offered though BGIA's CAP/CLIA and ISO-certified labs as well as mass spec service center.

40 Manning Road Manning Park Billerica, MA, 01821 United StatesBruker Daltonics develops and offers instruments to support mass spectrometry analysis.

120 Washington St, Suite 202 Salem, MA, 01970 United StatesWe are a professional services firm that helps life science companies translate data into biological results through machine learning, bioinformatics, cheminformatics, data infrastructure, data mining, and software and database engineering. We work with a variety of data types including genomic, transcriptomic, proteomic, metabolomic, meta-genomic, DNA-seq, bulk RNA-seq, single-cell RNA-seq, epigenetic, 16s & 18s, clinical, and diagnostic data. Read more about our services at https://bridgeinformatics.com/our-services/. We’ve built a team of bioinformaticians with experience at the bench whose core specialty is understanding and analyzing biological data. Meet our team at https://bridgeinformatics.com/about-us/#team.

1200 Salem St, Suite # 176 Lynnfield, Massachusetts, 01940 United StatesWe are a professional services firm that helps life science companies translate data into biological results through machine learning, bioinformatics, cheminformatics, data infrastructure, data mining, and software and database engineering. We work with a variety of data types including genomic, transcriptomic, proteomic, metabolomic, meta-genomic, DNA-seq, bulk RNA-seq, single-cell RNA-seq, epigenetic, 16s & 18s, clinical, and diagnostic data. Read more about our services at https://bridgeinformatics.com/our-services/. We’ve built a team of bioinformaticians with experience at the bench whose core specialty is understanding and analyzing biological data. Meet our team at https://bridgeinformatics.com/about-us/#team.

1200 Salem St, Suite # 176 Lynnfield, Massachusetts, 01940 United StatesWe are a professional services firm that helps life science companies translate data into biological results through machine learning, bioinformatics, cheminformatics, data infrastructure, data mining, and software and database engineering. We work with a variety of data types including genomic, transcriptomic, proteomic, metabolomic, meta-genomic, DNA-seq, bulk RNA-seq, single-cell RNA-seq, epigenetic, 16s & 18s, clinical, and diagnostic data. Read more about our services at https://bridgeinformatics.com/our-services/. We’ve built a team of bioinformaticians with experience at the bench whose core specialty is understanding and analyzing biological data. Meet our team at https://bridgeinformatics.com/about-us/#team.

1 Broadway 14th floor Cambridge, MA, 02142 United StatesWe are the leading CRO in zebrafish studies thanks to our more than 18 years of experience with this alternative model. During those years we have developed several validated assays on the areas of disease model generation, efficacy and toxicity carried to Pharma, Biotech, Chemical, Cosmetic, Nutraceutical, and Tobacco companies. Apart from our Know-How another of our main values is Audacity because we are experts in listening to our customer's needs to develop tailor-made solutions based on their requirements. Also thanks to our automated and innovative tools, our validated assays are carried out with our High Content Screening (HCS) platform, allowing us to perform fast and cost-effective assays in zebrafish: - Target Validation with Morpholinos or CRISPR/Cas13 - Zebrafish Disease Models: genetic mutations, transgenesis, and chemically induced models. - Toxicity Assays: acute toxicity, neurotoxicity, developmental/teratogenic toxicity, cardiotoxicity, hepatotoxicity, ototoxicity, immunotoxicity, nephrotoxicity, behavior alteration assay. - Ecotoxicity Assays: Algal Microplate toxicity test, Daphnia magna immobilization assay, endocrine disruption assay in zebrafish, and zebrafish larvae acute toxicity assay. - Efficacy Assays: Oncology (angiogenesis inhibition assay, target validation, cancer models generation, xenograft zebrafish embryos), CNS (Neuroprotection, Epilepsy, Parkinson, Alzheimer...), rare diseases, metabolism, immune system, cardiovascular… - Cosmetics: regeneration, melanin quantification, and antioxidant assays.

1 Broadway 14th floor Cambridge, MA, 02142 United StatesWe are the leading CRO in zebrafish studies thanks to our more than 18 years of experience with this alternative model. During those years we have developed several validated assays on the areas of disease model generation, efficacy and toxicity carried to Pharma, Biotech, Chemical, Cosmetic, Nutraceutical, and Tobacco companies. Apart from our Know-How another of our main values is Audacity because we are experts in listening to our customer's needs to develop tailor-made solutions based on their requirements. Also thanks to our automated and innovative tools, our validated assays are carried out with our High Content Screening (HCS) platform, allowing us to perform fast and cost-effective assays in zebrafish: - Target Validation with Morpholinos or CRISPR/Cas13 - Zebrafish Disease Models: genetic mutations, transgenesis, and chemically induced models. - Toxicity Assays: acute toxicity, neurotoxicity, developmental/teratogenic toxicity, cardiotoxicity, hepatotoxicity, ototoxicity, immunotoxicity, nephrotoxicity, behavior alteration assay. - Ecotoxicity Assays: Algal Microplate toxicity test, Daphnia magna immobilization assay, endocrine disruption assay in zebrafish, and zebrafish larvae acute toxicity assay. - Efficacy Assays: Oncology (angiogenesis inhibition assay, target validation, cancer models generation, xenograft zebrafish embryos), CNS (Neuroprotection, Epilepsy, Parkinson, Alzheimer...), rare diseases, metabolism, immune system, cardiovascular… - Cosmetics: regeneration, melanin quantification, and antioxidant assays.

Harvard Catalyst | The Harvard Clinical and Translational Science Center Boston, MA 02215REDCap is a free, secure, web-based application designed to support data capture for research studies. The system was developed by a multi-institutional consortium initiated at Vanderbilt University. Data collection is customized for each study or clinical trial by the research team with guidance from Harvard Catalyst EDC Support Staff. REDCap is designed to comply with HIPAA regulations. REDCap is not 21 CFR Part 11 compliant.

423 Brookline Ave Box 311 Boston, MA, 02215 United StatesAt Biotek Solutions Group, we take pride in being a Veteran-Owned, Pathology-based CRO, specializing in delivering excellence through high-quality, cost-effective, and efficient solutions. Since 2011, we have provided expert support to numerous biopharma companies in the areas of outsourced research, scientific, and pathology CRO needs. We understand that each project is unique, and our services are thoughtfully tailored to meet our client's specific specifications. Our team of experts excels in the following areas: Tissue control slides Tissue control blocks TMA construction Routine histopathology services Frozen sectioning Routine, special, and custom special staining Immunohistochemistry optimizations and validations Immunohistochemistry single and multi-staining TUNEL assay, ISH, CISH, FISH staining Digital Pathology routine slide scanning Digital Pathology immunofluorescence scanning Digital Pathology TMA scanning Pathologist support, annotations, and reporting Technical Director services and protocol development Expert CAP, CLIA, and regulatory consultations

423 Brookline Avenue Box 311 Boston, MA, 02215 United StatesAt Biotek Solutions Group, we take pride in being a Veteran-Owned, Pathology-based CRO, specializing in delivering excellence through high-quality, cost-effective, and efficient solutions. Since 2011, we have provided expert support to numerous biopharma companies in the areas of outsourced research, scientific, and pathology CRO needs. We understand that each project is unique, and our services are thoughtfully tailored to meet our client's specific specifications. Our team of experts excels in the following areas: Tissue control slides Tissue control blocks TMA construction Routine histopathology services Frozen sectioning Routine, special, and custom special staining Immunohistochemistry optimizations and validations Immunohistochemistry single and multi-staining TUNEL assay, ISH, CISH, FISH staining Digital Pathology routine slide scanning Digital Pathology immunofluorescence scanning Digital Pathology TMA scanning Pathologist support, annotations, and reporting Technical Director services and protocol development Expert CAP, CLIA, and regulatory consultations

99 Brookline Ave Boston, MA, 02115 United States

610N Lincoln Street Waltham, MA 02451 USABG Medicine is a life sciences company focused on the discovery, development, and commercialization of novel diagnostic tests based on biomarkers.

2414 Kirkbride Drive Danvers, MA, 01923 United States Bench Discoveries LLC, is a newly formed CRO providing preclinical services to the biotechnology, pharmaceutical and medical device industries developing therapeutics at the discovery stage of development. Our core staff consists of basic researchers with over 60 years’ experience combined and are highly skilled in utilizing animal models which are key to the evaluation of efficacy and safety towards clinical trials. Our widespread collaborations and industry contacts provide us with research tools offered as an external resource in imaging, analytical chemistry, histology and pathology services.

200 Turnpike Road Southborough, MA, 01772 United StatesBrunswick laboratories offers drug candidate analysis, high throughput screening, metabolism studies, assays, and disease models.

50 Prescott Street, Worcester MA 01605Blue Sky’s premium services include vector/gene construction, recombinant protein expression, laboratory-scale fermentation (scale-up bioprocessing), protein purification, assay development, and assay execution (screening).

Worcester, MA United StatesBlue Sky’s premium services include vector/gene construction, recombinant protein expression, laboratory-scale fermentation (scale-up bioprocessing), protein purification, assay development, and assay execution (screening).

300 TradeCenter, Suite 6650 Woburn MA01801 USABatavia Biosciences is a contract development organization for biopharmaceuticals and vaccines with end to end solutions for customers. The mission is to significantly contribute to ease human suffering from disease by improving the success rate in the translation of candidate medicines from discovery to the clinic. Hereto, the company has developed a portfolio of technologies aimed to improve product yield (STEP®, SCOPE®), reduce process development time (SIDUS®, SCOUT®) and increase product stability (SATIRN®). These technologies have amply demonstrated to improve speed and reduce cost in biopharmaceutical development, accelerating the journey from bench to clinic. Batavia Biosciences performs projects for big pharma, biotech, academia and non-profit organizations. The company employs a highly educated staff with many years of experience in DNA cloning, mammalian cell line generation, upstream and downstream process development (mammalian, microbial & insect cell platforms), purification development, product characterization, and clinical manufacturing. As such the company, with laboratories in USA and the Netherlands, is well positioned to take on any challenge associated with the development of complex biological medicines be it proteins, antibodies, vaccines or viral vectors.

37 GRAYSON LANE Newton Lower Falls, MA, 02462 United StatesOur company has developed a seasoned expertise in providing human biomaterials, frozen human tissues, DNA, RNA, as well as providing detailed and continual patient data management. With close proximity to academic and scientific institutions such as Harvard and MIT, our clients can be assured of the most up to date techniques and processes in the industry, including handling of materials such as whole blood, serum, plasma, and FFPE blocks. Our boutique approach to providing these procurement services guarantees that every biospecimen is specifically tailored to each client's needs. This custom service has made us an industry leader in the biotechnology, pharmaceutical, and related research fields. Our clients are assured of the highest quality products and customized service resulting from years of experience with global collection sites on three continents. We utilize our decades of experience on a global basis to provide our customers with a framework of scientific integrity, dedication, innovative spirit, and uncompromising service in providing human biomaterials. At Boston BioSource, our customers receive samples with complete histories and also, upon request, targeted therapy information. Highly experienced company technicians at our human tissue bank collect the samples, and staff physicians provide the histories. Samples are shipped to the United States for quality inspection from our global network of hospitals on three continents before delivery to your facility. In addition to our biorepository and international network, Boston BioSource has unique relationships with major medical centers in the Boston medical community, and a special collaboration with a CAP certified lab.

One Boston Medical Center Place Boston, MA 02118 USABoston Medical Center offers their many areas of therapeutic expertise in research and medical services.

Boston, MA United StatesBoston Medical Center offers their many areas of therapeutic expertise in research and medical services.

61 Binney Street Enders 1050 Boston, MA 02115Children’s Hospital Boston Molecular Genetics Core Facility offers microarray and sequencing services.

Edward Dougherty Department of Biology Brandeis University 415 South Street Waltham, Massachusetts 02454Our Imaging Lab provides instrumentation, training and support for facultiy and students in the acquisition and analysis of data using state of the art imaging equipment. Here researchers have access to equipment including Confocal, Transmitted light and, Epi- Fluorescence Microscopes. Computer work stations are also available with image processing software.

Medford, MA, USABioVolutions provides formulation, drug delivery, stability testing, toxicity testing, and packaging and labeling services.

215 First Street Cambridge, MA, 02142 United StatesBlueprint Medicines is a patient-driven oncology company developing highly selective kinase inhibitors for genomically defined cancer subsets.

MS 033 Brandeis University 415 South Street Waltham, Massachusetts 02453-2728 USAThe Ashton Graybiel Spatial Orientation Laboratory opened at Brandeis University on Oct. 20, 1982, with a two-day symposium on Achieving Manned Orbital Flight, Physiological Changes in Manned Space Flight, the Space Shuttle, and Man's Future in Space. Among the many speakers present were Charles Stark Draper, William E. Thornton, Lawrence Dietlein, Gordon Fullerton, and the Graybiel Lab's director, James Lackner. The generous material, financial and unswerving moral support by Dr. Lawrence F. Dietlein, deputy director of life sciences at NASA's Johnson Space Center, made the Ashton Graybiel Spatial Orientation Laboratory at Brandeis possible. The first experimental devices in the Graybiel Lab in 1982 included a short-arm centrifuge, a z-axis recumbent rotation device, a rotary treadmill enclosed in an optokinetic drum, and a Skylab rotating litter chair. Since the lab's inaugural opening, more than 20 major pieces of equipment have been designed and constructed or acquired for experiments. The largest of the experimental apparatuses in the lab is the 22-foot diameter rotating room, the only facility in the United States that can be used to simulate artificial gravity environments. The rotating room is used extensively and is at the center of many experiments studying the effects artificial force environments have on the neurocontrol of movement, posture, and orientation of the human body. Today, the Ashton Graybiel Spatial Orientation Laboratory comprises more than 20 Brandeis University faculty members, researchers, staff and students drawn from a variety of disciplinary backgrounds and academic and professional experiences.

The Venture Development Center - UMASS 100 Morrissey Blvd, Boston MA 02125-3393 USABIOARRAY Consulting provides breast cancer diagnostics and consulting for microarray discovery and gene expression profiling.

12 Gill Street, Suite 5450 Woburn, MA 01801-1728 USABioProcess Technology Consultants supports process/analytical development, quality and regulatory affairs, manufacturing strategy, and supply chain management.

Center for Life Science, Room 425 3 Blackfan Circle Boston, MA 02115The mass spectrometry, metabolomics and proteomics core at Beth Israel Deaconess Medical Center was established in 2004 led by Dr. John Asara and continues to grow rapidly. We provide excellent proteomics and metabolomics services with low prices and fast turnaround times. We have cutting edge equipment operated at optimal sensitivity and work and publish with world class researchers. We also maintain an active internal cancer proteomics and metabolomics research program with collaborative efforts. Our expertise is in identifying and quantifying protein modifications and dynamic protein-protein interactions in addition to polar metabolomics profiling including metabolic flux analyses. Several different types of mass spectrometers are available for services depending upon your needs including stand-alone linear ion trap for protein identification, hybrid ion trap-high resolution orbitrap for protein quantification and post-translational modification (PTM) mapping, and triple quadrupole mass spectrometers for targeted quantification of metabolites and peptides. We accept samples from anywhere in the world and look forward to helping you and progressing your research to the next level.

116 Templeton Parkway Watertown, MA 02472

Building 76-661 David H. Koch Institute 77 Massachusetts Avenue Cambridge, MA 02139Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

Enders 361 Boston Children’s Hospital 300 Longwood Ave. Boston, MA 02115Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

Enders 361 300 Longwood Ave. Boston, MA, 02115 United StatesOur lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

790 Memorial Drive Cambridge, MA 02139BioAnalytix is a pharmaceutically oriented spin-out from the Barnett Institute of Chemical and Biological Analysis at Northeastern University. Founded in 2012 by thought leaders in biologic drug development, regulatory strategy, and advanced analytics, BioAnalytix works with leading pharmaceutical companies to develop and apply advanced analytic technologies, methods and data in enabling, improving and accelerating biologic therapeutics from development through market.

790 Memorial Drive Cambridge, MA, 02139 United StatesBioAnalytix is a pharmaceutically oriented spin-out from the Barnett Institute of Chemical and Biological Analysis at Northeastern University. Founded in 2012 by thought leaders in biologic drug development, regulatory strategy, and advanced analytics, BioAnalytix works with leading pharmaceutical companies to develop and apply advanced analytic technologies, methods and data in enabling, improving and accelerating biologic therapeutics from development through market.

175 Crossing Boulevard, Suite 100 Framingham, MA 01702

Boston, MA United StatesBoston Area Diabetes Endocrinology Research Center (BADERC) offers its core facilities to support studies in cell biology, morphology, flow cytometry, metabolic physiology, molecular biology, and transgenic models.

Billerica, MA, USABruker Biospin offers analytical magnetic resonance instruments including NMR, preclinical MRI and EPR.

2 Eustis St, Quincy, MA 02170 USABiowit Technologies provides a broad and integrated service and product portfolio including molecular biology, virus packaging (e.g., adenovirus, AAV, lentivirus, retrovirus and baculovirus), protein expression, cell biology, stem cells and transgenic models.

Quincy, MA United StatesBiowit Technologies provides a broad and integrated service and product portfolio including molecular biology, virus packaging (e.g., adenovirus, AAV, lentivirus, retrovirus and baculovirus), protein expression, cell biology, stem cells and transgenic models.

Department of Medicine Beth Israel Deaconess Medical Center Dana Farber/Harvard Cancer Center Harvard Medical School 330 Brookline Avenue, CLS 402 Boston, MA 02115, USAThis facility will work as a resource specializing in preclinical testing in GEMs (genetically engineered mouse models) for investigators with preliminary evidence that an agent or a combination of drugs may target specific components of a cell pathway involved in human disease. Guided by the investigators preliminary results, the preclinical data will allow identification of key cellular components that should be targeted for the most effective treatment. This in turn enables efficient stratification of patients that are most likely to respond to novel agents or combination of therapies on the basis of their own specific genetic makeup. Our approach will streamline the progression from bench to bedside for promising agents, or new combinations of/indications for approved drugs. Accordingly, it will favor collaborations with pharma companies to support the identification of patient subgroups that will be responsive to specific treatments thereby allowing them to get rapid FDA approval for drugs

330 Brookline Avenue Boston, MA 02215Beth Israel Deaconess Medical Center provides flow cytometry, histology, genomic, imaging, microscopy, mass spectrometry, DNA sequencing, PCR, bioinformatics and proteomics services.

Boston, MA United StatesBeth Israel Deaconess Medical Center provides flow cytometry, histology, genomic, imaging, microscopy, mass spectrometry, DNA sequencing, PCR, bioinformatics and proteomics services.

Cambridge Innovation Center, 1 Broadway, 14th Floor Cambridge, MA, 02142 United StatesGreat science and technology sometimes needs a helping hand to catalyze its full potential- someone to guide and work as a member of their team to refine a business and/or operational practice. This is where Biobusiness fits in. Using 2.5 decades of hands-on experience and subject matter expertise combined with a customer-centric strategic approach we focus on helping you decrease the lag to achieving your clinical, research and business outcomes with ease and efficiency.

86 West Street Waltham, MA 02451B&V Testing provides comprehensive clean room testing, clean room certification and controlled environment testing, certification and repair services to the pharmaceutical, biotechnology, research, healthcare and medical device industries. Founded in 1978 and headquartered in the Life Sciences hub of Boston, with service offices in the Mid-Atlantic, B&V has expanded to become the largest provider of cleanroom and controlled environment testing, certification and decontamination services in the Northeast. Through our unwavering commitment to quality and consistent investment in training and accreditation during more than 35 years of continuous operation, B&V has established a national reputation for technical and service excellence.

763 Concord Ave, Cambridge, MA 02138Boston Open Labs offers DNA/RNA oligo synthesis, peptide synthesis, and molecular biology services in addition to supplying peptides, oligonucleotides, and reagents.

767c Concord Ave. Cambridge, MA 02138 USABioSciences Research Associates (BSR Associates) offers assay validation, assay development, cell culture, antibody, protein purification, flow cytometry, and medical device testing services.

19 Erie Drive Natick, MA, 01760 United StatesBoaoPharma offers fine chemicals, peptides, proteins, and antibodies in addition to peptide synthesis, protein expression, and antibody production.

Gryzmish B005 330 Brookline Avenue Boston, MA 02215Provides Services in Electron Microscopy The EM Core at BIDMC provides service, technical assistance, and instrumentation for electron microscopy techniques. Tissue processing for Transmission Electron Microscopy Sectioning for Transmission Electron Microscopy Ultrastructural analysis and image processing

8th Floor - Feldberg and Gryzmish Buildings 330 Brookline Avenue GZ-800 Boston, MA 02215 RESEARCH AND ACADEMIC AFFAIRS Academic Computing Animal Research Facility Clinical Trials Office Committee on Clinical Investigation Conflict of Interest Policy for Research Clinical Research Center Leadership Research Nursing Research Nutrition & Metabolism Services Laboratory Services Project Management Administration Holiday Schedule Contact Information Human Subjects Protection Office Institutional Animal Care and Use Committee Office of Sponsored Programs Research Facilities Office Research Pharmacy Technology Ventures Office SmallerLarger Clinical Research Center The Harvard Catalyst Clinical Research Center at Beth Israel Deaconess Medical Center provides scientists the resources necessary to maximize the efficient translation of results from basic and bench research to human clinical trials and patient care, thus improving patient outcomes. Services available to investigators include: Research Nursing Research Nutrition & Metabolic Services Laboratory Services, including specimen processing and storage Project Management by Clinical Research Coordinators and Research Nurses Clinical Support for Research Study Activities Dedicated Space for Participant Research Visits The Clinical Research Center is part of Harvard Catalyst | The Harvard Clinical and Translational Science Center. This NIH-funded initiative is a large-scale transformative effort across Harvard University, dedicated to improving human health. In addition to services offered through the Harvard Catalyst Clinical Research Center, Harvard Catalyst provides educational opportunities, consultative services, and opportunities for pilot funding of research projects.

167 Worcester Street Suite 211 Wellesley, MA 02481 USABioBridges offers contract staffing and consulting services for strategic planning and implementation of clinical trials.

300 Longwood Ave, Boston MA 02115The Clinical Research Center (CRC) at Boston Children's Hospital is an interdisciplinary, academic and service research center that provides assistance and education to the clinical research community at Children's. Within the Clinical Research Center there are four separate but interrelated cores Design and Analysis Core; Clinical Research Education Core; Development and Operations Core; and Clinical and Translational Study Unit. Clinical research is scientific investigation that is conducted with human subjects or on material of human origin such as tissues, specimens, cognitive phenomena or other data for which an investigator directly interacts with human subjects or for which material can be directly linked to an identifiable, living individual. Clinical research includes patient-oriented, community, and population-based research studies.

300 Longwood Ave, Boston , MA , 02115 United StatesThe Clinical Research Center (CRC) at Boston Children's Hospital is an interdisciplinary, academic and service research center that provides assistance and education to the clinical research community at Children's. Within the Clinical Research Center there are four separate but interrelated cores Design and Analysis Core; Clinical Research Education Core; Development and Operations Core; and Clinical and Translational Study Unit. Clinical research is scientific investigation that is conducted with human subjects or on material of human origin such as tissues, specimens, cognitive phenomena or other data for which an investigator directly interacts with human subjects or for which material can be directly linked to an identifiable, living individual. Clinical research includes patient-oriented, community, and population-based research studies.

Charles A. Dana Research Building, 8th Floor 330 Brookline Avenue Boston, MA 02215The function of the Histology Core is to provide services in paraffin histology for cells and tissues including: Embedding Sectioning Routine staining HISTOLOGY CORE Services Fees Getting Started Related Links Location Contact Us SmallerLarger Histology Core Provides Services in Paraffin Histology The function of the Histology Core is to provide services in paraffin histology for cells and tissues including: Embedding Sectioning Routine staining Fee Structure Work is done on a fee-for-service basis with a graded fee structure. Supplemental funding is provided by BIDMC and the Harvard Digestive Disease Center (HDDC). Priority use and reduced fees are given to investigators with these affiliations. Equipment Equipment in the facility includes: Leica automatic tissue processor Leica Autostainer Leica embedding station Leica paraffin microtomes.

100 Cummings Center Beverly MA 01915 USABio-Boston Contract Laboratories offers disease models, cell culture based assays, cell viability tests, immunohistochemistry, and apoptosis assays.

Beverly, MA United StatesBio-Boston Contract Laboratories offers disease models, cell culture based assays, cell viability tests, immunohistochemistry, and apoptosis assays.

Slosberg-Landay Building 330 Brookline Ave. Boston, MA 02215 ZEBRAFISH CORE SmallerLarger Zebrafish Core Summary The BIDMC Zebrafish Core Facility is is a newly designed 3,000+ fish tank facility, located in the Slosberg-Landay building. It is a state-of-the-art 2,500 sqft facility built by Pentair Aquatic Habitats. The facility is equipped with 48 racks which hold standard sized adult zebrafish tanks, a three rack nursery space for larval fish, and a quarantine space containing two stand-alone housing systems. Wild-type lines are maintained inhouse for shared use. Wet lab space is available for breeding and line maintenance; core staff and facility-associated technicians perform daily feeding. The core includes a dedicated procedure room for embryo manipulation. Since 2011, a full time manager staffs the facility and is available for assistance with access, training and general Zebrafish husbandy questions. All BIDMC Zebrafish Core users must be associated with an IACUC-approved animal protocol.

840 Memorial Drive Cambridge, MA, 02139 United StatesAt bluebird bio, we are leading the way to the industrialization of gene therapy.

RN 194 99 Brookline Ave Boston, MA 02215-5491The Beth Israel Deaconess Transgenic Core Facility opened in October of 1991.The Transgenic Core is a state-of-art facility that produces genetically altered animals. Service: Pronuclear stage zygotes are injected with CRISPR reagents for the purpose of creating knockouts or knockins. We have observed increased efficiency when investigators have purchased all their reagents (Cas9 enzyme, nickase, sgRNA and DNA). In 3 recent (October ’15) knockin projects, utilizing Cas9 nickase and two sgRNA9(s) there were 5/65, 9/73 and 6/59 (founders/pups screened). The source of reagents were: Recombinant Cas9 nickase: PNA bio Inc (www.pnabio.com); catalog number CN01; 50ug/vial. The company also provides Cas9 enzyme (see website for cat #). sgRNA(s): PNA Bio Inc (www.pnabio.com); (sgRNA synthesis service; 50ug lyophilized). No catalog number. Oligo DNA (knockins): IDT (www.idtdna.com) as a 4 nmole Ultramer DNA oligo. For large-fragment knockins, such as ires-cre or GFP fluorescent proteins, a DNA vector containing homologous fragments needs to be constructed and provided by investigators. The reagents are injected in the following concentrations (manufacturer recommendation): Cas 9 (200ng/ul), sgRNA(s) (100ng/ul), DNA (20-60ng/ul). A mix of the reagents totaling 50ul is made and is used for one week. Reagents may be presented to the Core in a lyophilized form or reconstituted in culture grade water with enough aliquots of the Cas 9 and sgRNA to allow the lab to make at least 3 mixes.

100 TradeCenter, Suite G-700 Woburn, MA 01801 USABioss Inc is a leading antibody developer and manufacturer with state of the art technologies offering antibodies, proteins, and ELISA Kits. We have developed over 11,000 primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.

Woburn, MA United StatesBioss Inc is a leading antibody developer and manufacturer with state of the art technologies offering antibodies, proteins, and ELISA Kits. We have developed over 11,000 primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.

400 Trade Center Dr Ste #2990 Woburn, MA, 01801 United StatesBioss Inc is a leading antibody developer and manufacturer with state of the art technologies offering antibodies, proteins, and ELISA Kits. We have developed over 11,000 primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.

400 tradecenter drive suite 2990 Woburn, Massachusetts, 01801 United StatesBioss Inc is a leading antibody developer and manufacturer with state of the art technologies offering antibodies, proteins, and ELISA Kits. We have developed over 11,000 primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.

10P Gill Street Woburn, MA 01801BIOCIUS Life Sciences offers in vitro ADME screening, CYP inhibition, and metabolic stability services.

330 Brookline Avenue, Room ES-OB01 Boston, MA 02215The TCIF at the Beth Israel Deaconess Medical Center (BIDMC) fills a major unmet need at Harvard Medical School and all of Massachusetts, namely, the cGMP manufacture and aseptic fill-finish of non-radioactive and radioactive pharmaceuticals to enable first-in-human trials of novel molecules. Construction of the facility was funded by an ARRA grant from the NIH and was completed in August of 2013. The TCIF is a state-of-the-art 1,400 sq ft facility designed for the cost-efficient, time-efficient, and safe cGMP manufacturing and aseptic fill-finish of novel non-radioactive or radioactive in vivo diagnostic and therapeutic agents for cancer and other diseases.

One Silber Way Boston, MA 02215 USABoston University has multidisciplinary research institutes and centers to support any investigator.

Boston, MA United StatesBoston University has multidisciplinary research institutes and centers to support any investigator.

763E Concord Ave. Cambridge Massachusetts 02138BioAxone is committed to applying a deep understanding of axon regeneration and neuronal signaling pathways to transform the lives of patients afflicted with neurotrauma or neurovascular disorders. Led by a passionate management team augmented by 20 years of pioneering research, the company has identified and is developing a pipeline of drugs focused on nerve repair and regeneration.

Boston Showroom 57 Water St. Watertown, MA 02472BioSurplus is a leading, nationwide provider of pre-owned laboratory equipment to the Life Sciences industry. In addition to offering quality and affordable pre-owned laboratory instruments for start-up labs, mid-sized companies, large pharma and academia, BioSurplus assists all organizations with monetizing surplus equipment through its direct purchase, consignment and/or auction programs. BioSurplus has successfully served the Life Sciences industry for more than ten years and is proud to provide quality and affordable pre-owned lab equipment with exemplary customer service.

245 Constitution Drive Taunton, MA 02780 USABiodirect Inc. carries used laboratory systems and supplies at great discount prices. We also offer laboratory system repairs.

15 Elizabeth Drive Chelmsford, MA, 01824 United States

300 Longwood Ave, Boston MA 02115The Boston Children’s Hospital Viral Core is located on the 13th floor of the Center for Life Science (CLS) building and provides technological resources to academic investigators interested in the development and use of viral based vectors. Currently, it offers custom lentiviral vector production, custom AAV vector production with a variety of serotypes and aliquots of in-stock vector. The Viral Core operates under the direction of Dr. Zhigang He and is managed by Dr. Chen Wang with technical support staff.

Danvers Campus 36 Cherry Hill Drive Danvers MA 01923Beckman Coulter develops, manufactures and markets products that simplify, automate and innovate complex biomedical testing. Our products are making a difference in people’s lives by improving the productivity of medical professionals and scientists, supplying critical information for improving patient health and delivering trusted solutions for research and discovery.

36 Cherry Hill Drive Danvers, MA, 01923 United StatesBeckman Coulter develops, manufactures and markets products that simplify, automate and innovate complex biomedical testing. Our products are making a difference in people’s lives by improving the productivity of medical professionals and scientists, supplying critical information for improving patient health and delivering trusted solutions for research and discovery.

75 Francis Street Boston, MA 02115 USABrigham and Women's Hospital offers anatomic pathology, molecular diagnostic, cytogenetic, and blood banking services.

Boston, MA United StatesBrigham and Women's Hospital offers anatomic pathology, molecular diagnostic, cytogenetic, and blood banking services.

Charles A. Dana Research Building, Room 707A 330 Brookline Avenue Boston, MA 02215The goal of the Small Animal Imaging Core (Longwood Small Animal Imaging Facility) is to provide state-of-the-art small animal imaging services to researchers in the Longwood Medical Area of Harvard Medical School. These services include multi-modality imaging, advanced data analysis, image fusion resources, and a satellite animal facility for longitudinal studies. We have solved the logistical problems of importing animals from other institutions and now have a streamlined system bring animals into the facility. We want to make this a one-stop service for you. Simply bring us the animals, and we will take care of all anesthesia and imaging, and will assist you with data analysis and display. You will leave with all the data you need on a CD, DVD, or USB memory stick. We also have state-of-the art data analysis and fusion facilities to assist you as well.

700 Albany Street Boston, MA, 02118 United States

361 Whitney Ave. Holyoke MA, 01040

Boston, MA United StatesBerg Diagnostics is a Boston based molecular diagnostics company that offers high-throughput omics-based molecular profiling, biomarker validation, and regulated bioanalysis to accelerate development of molecular therapeutics and diagnostics. Armed with the state-of-the-art instrumentation platforms, the company serves to catalyze project end-points in therapeutic and biomarker development.

Boston, MA United StatesChildren’s Hospital Boston Stem Cell Core Facility offers flow cytometry, cell cycle analysis, cell sorting, and cell analysis services.

330 Brookline Avenue, Boston, MA 02215The Research Glasswashing Core is primarily responsible for the cleaning and sterilization of reusable laboratory glassware, reagents, and equipment. This centralized service eliminates the need for individual investigators to maintain space, equipment, and personnel in their own laboratories to handle washing and sterilization. The core provides service to all researcher buildings and is available for an hourly rate.

330 Brookline Avenue, Boston, MA 02215The Preclinical MRI Core at the Beth Israel Deaconess Medical Center offers instrumentation and expertise for a broad range of magnetic resonance imaging and spectroscopy applications for small animals, excised tissue and cell culture studies. We provide fee for service within BIDMC and to outside investigators.

Brigham and Women’s Hospital, Channing Division of Network Medicine 221 Longwood Ave Eugene Braunwald Research Center, 6th Floor Boston, MA 02115The BWH/Harvard Cohorts Biorepository Core manages over 3.2 million biological specimens collected from over 200,000 participants in several large cohort studies. The Core prepares and ships over 60,000 biospecimens annually to collaborating laboratories for analyses evaluating the relationship between biomarkers and chronic disease risk. These cohort studies include: Nurses’ Health Study (NHS) Nurses’ Health Study II (NHSII) Health Professionals Follow-up Study (HPFS) Physician’s Health Study (PHS) Growing Up Today Studies (GUTS/GUTSII) Biospecimens collected from each of these cohorts are being actively utilized in epidemiologic research studies of cancer, cardiovascular disease, and diabetes, among others. The biospecimens from these cohorts are richly enhanced by up to 30 years of health-related behaviors and medical histories, making them a unique and invaluable research resource. Sample types stored in the biorepository include plasma, white blood cells, red blood cells, whole blood, urine, DNA, toenails, hair, stool, and saliva. These samples are an extremely valuable, but finite, resource; thus much effort is put forth to ensure high quality, efficient specimen handling. The goal of the Biorepository is to maximize use of samples in a cost-effective, ethical, state of the art manner.

759 Chestnut Street Springfield, MA 01199The Epidemiology and Biostatistics Research Core (EBRC) supports Baystate faculty, fellows and residents in clinical research and research education. The EBRC has a staff of five epidemiologists with Masters or PhD-level training who have broad expertise in research methods, data analysis, and scientific writing. They have a total of more than 70 years’ experience in clinical research, have published several hundred articles in major scientific journals, and handle more than 200 projects a year. RESEARCH SUPPORT The EBRC collaborates with clinical investigators by: Developing study designs and research protocols, including: Randomization schemes Power analysis and sample size computations Relevant written sections of grants, manuscripts, and presentations Assisting in developing survey instruments Creating databases and data entry schemes in RedCap (Research Electronic Data Capture) Conducting data analyses, including: Linear regression and ANOVA Logistic regression (unconditional, conditional, multinomial, and ordered) Time-to-event analysis, hierarchical linear modeling, analysis of complex survey designs. Meta-analysis Geographic Information Systems (GIS) and spatial analysis

Research North 99 Brookline Ave. Boston, MA 02215The X-ray Crystallography Facility located at 99 Brookline Ave. (Research North) was recently established as a core to serve the needs of investigators in the BIDMC and Harvard Medical School community interested in using structural biology as a tool in their research. The laboratory houses instrumentation consisting of : Micromax 007 X-ray generator R-Axis HTC detector Osmic VariMax HF confocal optics X-Stream 2000 cryogenic device for data collection at 100K A Peak Scientific nitrogen generator Two Olympus microscopes are available for inspecting and photographing crystal trays Two incubators (4ºC - 25ºC) are available for crystallization experiments A Leica Z6 Stereo Microscope with polarizer A Spot Flex 15.2 64 Mp Shifting Pixel Digital Camera TTPLabtech Mosquito nanolitre crystallization robot Supporting computing facilities include several Linux PCs which can be used for data acquisition, analysis and processing.

304 Pleasant St., Watertown, MA 02472

Dana 814 330 Brookline Avenue Boston, MA 02215Provides Services in Confocal microscopy, Light microscopy and immunostaining The function of the Confocal Core is to provide services in confocal microscopy, light microscopy and immunostaining for cells and tissues including: Confocal microscopy Brightfield and fluorescence microscopy Immunoperoxidase and immunofluorescence staining

75 Francis Street Boston, MA, 02115 United StatesThe Pathology Specimen Locator (PSL, formerly known as Virtual Specimen Locator (VSL)) is a Harvard Medical School wide consortium of four major teaching hospitals (BWH, MGH, BIDMC, and CHB) that help in identification and retrieval excess human tissues for research. It is set up as a core in the Dana Farber/Harvard Cancer Center (DF/HCC).

Center for Complex Systems Volen Center 206/MS 013 415 South Street Waltham, MA 02454-9110The Volen National Center for Complex Systems was formed for the purpose of studying the brain and intelligence. The Center is composed of faculty members who specialize in artificial intelligence, cognitive science, and a wide range of topics in neuroscience including experimental psychology, computational neuroscience, and cellular and molecular neurobiology. The Center is an interdisciplinary group with the ability to perform scientific analysis of the brain from the cellular and molecular levels to the cognitive and computational. The Center aims to increase knowledge within each of its individual component disciplines, as well as to foster interactions among the components, giving rise to new scientific initiatives. Interested students should concentrate in one of these component disciplines: biochemistry, biology, chemistry, computer science, linguistics and cognitive science, neuroscience, physics, or psychology.

Waltham, MA, 02453 United StatesThe Volen National Center for Complex Systems was formed for the purpose of studying the brain and intelligence. The Center is composed of faculty members who specialize in artificial intelligence, cognitive science, and a wide range of topics in neuroscience including experimental psychology, computational neuroscience, and cellular and molecular neurobiology. The Center is an interdisciplinary group with the ability to perform scientific analysis of the brain from the cellular and molecular levels to the cognitive and computational. The Center aims to increase knowledge within each of its individual component disciplines, as well as to foster interactions among the components, giving rise to new scientific initiatives. Interested students should concentrate in one of these component disciplines: biochemistry, biology, chemistry, computer science, linguistics and cognitive science, neuroscience, physics, or psychology.

759 Chestnut Street Springfield, MA 01199The Baystate Research Facility (BRF) is a 25,000 square foot facility that includes ample bench space for basic science research, tissue culture, surgical and procedural rooms, BSL-2 room, histology suite, microscopy suite and additional specialty lab space. In addition to research space the BRF has private offices, an open community area, three conference rooms and a reception area. The BRF core team includes individuals trained in laboratory safety, skilled veterinary care, regulatory issues, as well as individuals performing general administrative functions. Types of research being conducted at the BRF include cancer, diabetes, surgical techniques and training, and device/instrument development. LOCAL OVERSIGHT The Institutional Review Board oversees and evaluates all research involving humans The Institutional Animal Care and Use Committee (IACUC) oversees and evaluates all animal care and use and is also responsible for initial and continuing review and approval or all animal use protocols. The IACUC assures USDA and OLAW regulations and national standards are met. The Institutional Biosafety Committee reviews registrations for Recombinant or Synthetic Nucleic Acid Molecules, Pathogens, potential Infectious Agents, Biological Toxins, and Human Clinical Trials that involve the use of these materials as mandated by the National Institutes of Health.

W. M. Keck Institute for Cellular Visualization 415 South Street Waltham, MA 02454The W. M. Keck Institute for Cellular Visualization is located on the 4th floor of the Rosenstiel Basic Medical Sciences Research Center at Brandeis University in Waltham, Massachusetts. Instruments and training are available for faculty, staff, and other lab members across the University. The Institute and EM Facility are under the direction of Dr. Christopher Miller and managed by Mike Rigney.

330 Brookline Avenue, Boston, MA 02215Primary Goals of the MGTP Core: To make MGTP mRNA quantification services available to investigators, and assist them in advancing their research and obtaining grants; To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes, through our primer distribution service.

101 Main St United States cambridge, MA, 94070 United StatesBC Platforms is a global leader in providing a powerful data and technology platform for personalized medicine and drug development, accelerating the translation of insights into clinical practice. BC Platforms operates the Global Data Partner Network BCRQUEST.com, which provides access and analytics on genomic and clinical cohort data for drug developers currently providing access to over 16m subjects across five continents. Our technology drives the infinite loop between personalized care and research discoveries, leveraging latest science, deep technical expertise, strategic partnerships, and harmonized, diverse data collections. Our high performing platforms enable high throughput genomic data production, flexible data integration, secure data management, efficient analysis and interpretation of molecular and clinical information. Founded in 1997 from an MIT Whitehead project spinoff, the Company has a strong scientific heritage underpinned by over 20 years of working in close collaboration with a network of leading researchers, developers, manufacturers and vendors. BC Platforms has global operations with its headquarters in Zurich, Switzerland, research and development in Espoo, Finland, and sales and marketing in Boston, USA, London, UK and Singapore. For more information, please visit www.bcplatforms.com.

13 Larch Row Wenham, MA, 01984 United States

Boston, MA United StatesBoston Cytometry offers cytometry services in support of drug research and development.

Boston, MA, USABoston Cytometry offers cytometry services in support of drug research and development.

77 Avenue Louis Pasteur Boston, MA 02115Biopolymers Facility of Harvard Medical School provides DNA and RNA purification, genotyping, PCR, oligonucleotide synthesis, and sequencing services.

Boston, MA United StatesBiopolymers Facility of Harvard Medical School provides DNA and RNA purification, genotyping, PCR, oligonucleotide synthesis, and sequencing services.

3 Blackfan Circle 14th Floor (#14066) Boston, MA 02115The promise of using patient-derived neurons to create disease models for drug screening is starting to bear fruit across a variety of neurological disorders vastly underserved by available therapies. New examples of human inducible pluripotent stem cell (iPSC) derived models of neurological disorders have identified a range of disease-relevant phenotypes by using specifically differentiated neuronal sub types, including Alzheimer’s disease, Amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Rett syndrome, and several copy number variants (CNVs) associated with neuropsychiatric disorders and autism. The quality of patient care and research at BCH provides well-studied psychiatric and neurological patient populations that will facilitate additional development of preclinical disease models using iPSCs to support drug screening. The recently formed Translational Neuroscience Center (TNC) at BCH created a Human Neuron Differentiation Service (HNDS) to prepare human neurons for researchers at BCH and the surrounding area using iPSC lines created from well-phenotyped and genotyped patients using optimized protocols for specific neuronal cell types. This service has begun addressing a large unmet need in the research community. The existing Assay Development Screening Facility (ADSF) core facility within the FM Kirby Neurobiology Center at BCH also provides complementary resources in the form of a high-throughput screening instrument to investigators for monitoring functional responses of neurons and other cell types. These paired facilities enable faculty to create neurons, develop assays, and run drug screens for new therapeutic approaches to disease.

Bassine 213, Waltham, Massachusetts 02453-2728The Brandeis University National Center for Behavioral Genomics (NCBG) consists of seven research groups focused on brain function and behavior. The seven lab heads are all distinguished researchers and faculty members in the Brandeis Biology Department. All groups are located in the Shapiro Science Center. The Shapiro Science Center is a new, state-of-the-art structure and a focal point of Brandeis' expansive science complex.

450 South Street Waltham, MA, 02453 United StatesThe Brandeis University National Center for Behavioral Genomics (NCBG) consists of seven research groups focused on brain function and behavior. The seven lab heads are all distinguished researchers and faculty members in the Brandeis Biology Department. All groups are located in the Shapiro Science Center. The Shapiro Science Center is a new, state-of-the-art structure and a focal point of Brandeis' expansive science complex.

100 Cummings Center, Suite 107A Beverly, MA 01915 USABIOBASE Biological Databases offers data collection and analysis, gene expression analysis, pathway modeling, and biological databases.

Cambridge, MA United StatesBiocair provides shipping for scientific materials.

840 Memorial Drive United States Cambridge, MA, 02139 United StatesBoston Biochem offers Ubiquitin Proteasome Pathway products and services and Custom Enzyme Purifications

300 Longwood Ave, Boston MA 02115The assay development and screening facility (ADSF) is located on the 12th floor of the Center for Life Sciences Building situated in the heart of the Longwood Medical community. The core provides investigators with access to cutting edge drug screening and automated lab equipment, a large repository of chemical libraries for identification of novel molecules that can be used to study any biological system of interest. We support assay development for high-throughput screening, provide for the screening of libraries to obtain preliminary data for grant proposals, as well as screening of large libraries for identification of leads for drug discovery and therapeutics. The ADSF is anchored by a Hamamatsu FDSS7000EX kinetic reader, which has the capability of conducting measurements of fluorescence or luminescence in 384 wells at once, with time resolution of up to 40Hz. The equipment allows for measurements of changes in membrane potential and concentration of intracellular ions such as Ca2+ in primary cultures, stem cell-derived or trans-differentiated cells or cell lines in a fast, accurate, parallel fashion. As a counterfoil to the Hamamatsu we have a confocal based high-content screening (HCS) platform, ThermoFisher's Arrayscan XTI. This HCS instrument features a temperature and CO2 controlled live cell chamber to assay your biology over several days. The arrayscan XTI has an integrated liquid handler to administer your substrate of interest, well by well, capturing changes in fluorescence upto 10Hz with an enhanced CCD camera and 7 LED light source using 6 to 1536 well labware. In partnership with another local screening facility we have access to nearly 1,000,000 unique pharmacological entities from a variety of academic and commercial vendors. The core works closely with investigators to develop and initiate large or small scale screens and can direct investigators to resources for further lead development. The core is under the direction of Dr. Mustafa Sahin and managed by Dr. Lee Barrett. Alyssa Grantham is the Core's dedicated Research Assistant. The Core is under the administrative guidance of Amy Weinberg, MHP, CRA, administrator of the IDDRC.

7 Jackson Road Devens, MA 01434 USABionostics offers quality control and calibration solutions to support analytical testing and manufacturing.

Center for Life Science, CLS-0932 330 Brookline Ave Boston, MA 02215Committed to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting. It is continuously expanding with the newest software and machinery for both sort and analysis capabilities of up to 18 flourescent parameters. Our Services The Flow Cytometry Core facility is available to: answer technical questions assist you in setting up flow cytometry experiments assist you with acquiring, analyzing and interpreting your data assist in data presentation and data storage provide training on the four benchtop analyzers and on software

75 Francis Street Boston, MA, 02115 United StatesThe Crimson Biomaterials Collection Core Facility prospectively collects discarded clinical materials matching investigator-defined criteria against available information on clinical samples, including ICD.9 codes and results of clinical laboratory testing. The core provides a web-based software application, called “Crimson” to allow investigators and associated study staff to manage collected sample repositories and associated data.

Boston, MA, 02118 United States

330 Brookline Avenue, Boston, MA 02215The Core helps researchers and quality improvement teams use the vast array of data available in today's healthcare world. As a part of operations, BIDMC collects and stores large amounts of electronic data. We also have an extensive research and quality improvement community. However, high-quality analysis of this data requires iterative refinement of queries and cohort building by experts familiar with both the data and with working with investigators and improvers. The InSIGHT Core provides a translation layer, helping our researchers and QI teams get access to reliable, high quality data in a way they can use it.

107 Avenue Louis Pasteur Boston, MA 02115The mission of the Biomedical Research Informatics Core (BRIC) is to utilize the expertise of BIDMC "informaticians" with backgrounds in medicine, biology, engineering, biostatistics, and computer science to facilitate research at our institution by (a) providing a high level of service and experience in informatics that is difficult for individual laboratories to achieve and maintain, (b) developing the infrastructure required to address common informatics needs of all researchers, and (c) identifying areas in which there can be closer collaboration among life scientists and quantitative scientists. Services BRIC is an informatics unit with a focus on delivering services to BIDMC researchers related to creating and managing HIPAA compliant databases designing and updating attractive internet websites implementing software and web-based applications assisting with the selection and use of data analysis tools developing novel analysis techniques We also help coordinate projects between several other informatics groups including Academic and Research Computing Clinical Data Repository Division of Interdisciplinary Medicine and Biotechnology General Clinical Research Center (GCRC) Genomics Center Media Services

320 Needham Street Suite 150 Newton, Massachusetts 02464 United StatesBBK Worldwide provides investigator and ptient recruitment services.

36 Symphony Road Suite 2A Boston, MA, 02115 United StatesBioEnergetics specializes in mitochondrial respirometry and provides an affordable solution for customers looking to determine the bioenergetic profile of their ex-vivo, in-vitro and in-vivo projects, including mitochondrial toxicity profiles of drug candidates and customized models for bioenergetic profiles using the Seahorse Bioscience XF96 platform.

990 Washington St. Suite 105 Dedham, MA, 02026 United StatesBoca Scientific Incorporated was established in 2002. We bring innovative Biotechnology products from around the world to research labs in the United States and Canada. We are proud to offer a carefully curated selection of leading edge Molecular Biology, Immunology, Cell Biology, and Diagnostics products as well as our freezer storage systems. Our product offering includes a unique selection of research and diagnostic reagents, kits, and laboratory supplies.

800 Washington Street Ziskind 417 Boston, MA, 02111 United States

800 Washington Street Ziskind 417 Boston, MA, 02111 United States

204 2nd Ave. Suite 1 Waltham, MA, 02451 United StatesWith over 20 years of experience in developing custom antibodies, proteins and peptides, we provide comprehensive service programs that cover Antibody Services from antibody development to large scale production; Protein Services from recombinant protein production to downstream Crystallography; Peptide Services from peptide synthesis, labeling, peptide library and GMP peptide.

204 2nd Ave. Suite 1 Waltham, MA, 02451 United StatesWith over 20 years of experience in developing custom antibodies, proteins and peptides, we provide comprehensive service programs that cover Antibody Services from antibody development to large scale production; Protein Services from recombinant protein production to downstream Crystallography; Peptide Services from peptide synthesis, labeling, peptide library and GMP peptide.

1309 BEACON STREET Suite: 300 Brookline, MA, 02446 United StatesBay Biosciences provides high quality human tissue samples and biofluids for research. Bay BioSciences procures hard to find human tissue samples from rare diseases, our product offering covers large spectrum of human tissue and biomaterials for research.

150 Huntington Ave Apt. SDL Boston, MA, 02115 United StatesWe are experts in developing in vitro 3D Human-derived Adipose Tissue and Heart Spheroids and Organoids. Our 3D human models are self-assembled and Matrigel-free, setting us apart from our competitors. Our 3D human models are morpho-functionally validated compared to classic 2D models widespread in drug discovery and development. In addition, we provide consulting in 3D technologies and confocal and high throughput microscope imaging focused on morphological and functional characterization of 3D models. OUR PORTFOLIO FOR ADIPOSE TISSUE INCLUDES: - Models derived from human adult cells. Stromal vascular fraction, SFV of both subcutaneous and visceral fat depots, the latter an exclusive product that sets us apart in the market. - Bonds Bio 3D human Adipose Tissue organoids in the most advanced platform to access mitochondrial respiration (OCR) and glycolysis (ECAR) (3D Seahorse plates - Seahorse, Agilent) ready to treat and read. - 2D-to-3D transition kits containing 96-well plates with 3D progenitor organoids and 96-well plates with 2D progenitor cells in a monolayer to run Bonds Bio Adipose Tissue differentiation protocol in parallel (Subcutaneous or Visceral). This transition kit is for you who need an extra layer of confidence before a complete transition to Bonds Bio 3D human mature organoids. We provide our organoids in 96- and 384-well plates, with individual organoids per well, an outstanding source of unique feature samples for your testing, allowing for mid-to-large scale analysis and compatible with the most common high-throughput systems available in the market. Our models are validated using cells from healthy donors (commercially available now) and Patient-Derived Organoids (PDOs) with samples from different ages, races, BMI index, and diseases (e.g., Type 2 diabetes, cancers). (For more information on our PDO line, contact us). COMING SOON… In addition to the human adult SVF-derived adipose tissue models, we are developing outstanding Adipose Tissue and Heart 3D human models derived from human-induced pluripotent stem cells (hiPSCs). We are now differentiating hiPSCs into subcutaneous, visceral, and beige-like adipocytes to assemble the next generation of Bonds Bio 3D human Adipose Tissue Organoids from hiPSCs. Last but not least, very soon, we will launch our hiPSC-derived Heart spheroids and Heart Organoids for you to test drugs cardiotoxicity and cardiovascular diseases in two outstanding platforms, more sensitive than their 2D peers and less complicated to handle than engineered-heart tissues (EHTs). Your heart will "beat faster" with Bonds Bio 3D Heart models (For more information on our Cardio line, contact us). ABOUT OUR COMPANY The development of human physiologically relevant 3D organoids is made more accessible with Bonds Biosystems. Our Mission is to turn INNOVATIVE science into more accurate and affordable therapies for patients worldwide through In VITRO 3D solutions, envisioning the creation of technologies that accelerate drug development, enhancing new therapies' efficacy to bring new HOPES to humankind, preferably reducing costs and reducing or even avoiding the need for animal models use. If you want to be a part of this revolution of in vitro biology, do not hesitate to contact us at bondsbio.com/contact We are looking forward to helping you to transform your 3D experience!

27 Strathmore Road attn. Bonds Biosystems Natick, 01760 United StatesWe are experts in developing in vitro 3D Human-derived Adipose Tissue and Heart Spheroids and Organoids. Our 3D human models are self-assembled and Matrigel-free, setting us apart from our competitors. Our 3D human models are morpho-functionally validated compared to classic 2D models widespread in drug discovery and development. In addition, we provide consulting in 3D technologies and confocal and high throughput microscope imaging focused on morphological and functional characterization of 3D models. OUR PORTFOLIO FOR ADIPOSE TISSUE INCLUDES: - Models derived from human adult cells. Stromal vascular fraction, SFV of both subcutaneous and visceral fat depots, the latter an exclusive product that sets us apart in the market. - Bonds Bio 3D human Adipose Tissue organoids in the most advanced platform to access mitochondrial respiration (OCR) and glycolysis (ECAR) (3D Seahorse plates - Seahorse, Agilent) ready to treat and read. - 2D-to-3D transition kits containing 96-well plates with 3D progenitor organoids and 96-well plates with 2D progenitor cells in a monolayer to run Bonds Bio Adipose Tissue differentiation protocol in parallel (Subcutaneous or Visceral). This transition kit is for you who need an extra layer of confidence before a complete transition to Bonds Bio 3D human mature organoids. We provide our organoids in 96- and 384-well plates, with individual organoids per well, an outstanding source of unique feature samples for your testing, allowing for mid-to-large scale analysis and compatible with the most common high-throughput systems available in the market. Our models are validated using cells from healthy donors (commercially available now) and Patient-Derived Organoids (PDOs) with samples from different ages, races, BMI index, and diseases (e.g., Type 2 diabetes, cancers). (For more information on our PDO line, contact us). COMING SOON… In addition to the human adult SVF-derived adipose tissue models, we are developing outstanding Adipose Tissue and Heart 3D human models derived from human-induced pluripotent stem cells (hiPSCs). We are now differentiating hiPSCs into subcutaneous, visceral, and beige-like adipocytes to assemble the next generation of Bonds Bio 3D human Adipose Tissue Organoids from hiPSCs. Last but not least, very soon, we will launch our hiPSC-derived Heart spheroids and Heart Organoids for you to test drugs cardiotoxicity and cardiovascular diseases in two outstanding platforms, more sensitive than their 2D peers and less complicated to handle than engineered-heart tissues (EHTs). Your heart will "beat faster" with Bonds Bio 3D Heart models (For more information on our Cardio line, contact us). ABOUT OUR COMPANY The development of human physiologically relevant 3D organoids is made more accessible with Bonds Biosystems. Our Mission is to turn INNOVATIVE science into more accurate and affordable therapies for patients worldwide through In VITRO 3D solutions, envisioning the creation of technologies that accelerate drug development, enhancing new therapies' efficacy to bring new HOPES to humankind, preferably reducing costs and reducing or even avoiding the need for animal models use. If you want to be a part of this revolution of in vitro biology, do not hesitate to contact us at bondsbio.com/contact We are looking forward to helping you to transform your 3D experience!

27 Strathmore Road attn. Bonds Biosystems Natick, 01760 United StatesWe are experts in developing in vitro 3D Human-derived Adipose Tissue and Heart Spheroids and Organoids. Our 3D human models are self-assembled and Matrigel-free, setting us apart from our competitors. Our 3D human models are morpho-functionally validated compared to classic 2D models widespread in drug discovery and development. In addition, we provide consulting in 3D technologies and confocal and high throughput microscope imaging focused on morphological and functional characterization of 3D models. OUR PORTFOLIO FOR ADIPOSE TISSUE INCLUDES: - Models derived from human adult cells. Stromal vascular fraction, SFV of both subcutaneous and visceral fat depots, the latter an exclusive product that sets us apart in the market. - Bonds Bio 3D human Adipose Tissue organoids in the most advanced platform to access mitochondrial respiration (OCR) and glycolysis (ECAR) (3D Seahorse plates - Seahorse, Agilent) ready to treat and read. - 2D-to-3D transition kits containing 96-well plates with 3D progenitor organoids and 96-well plates with 2D progenitor cells in a monolayer to run Bonds Bio Adipose Tissue differentiation protocol in parallel (Subcutaneous or Visceral). This transition kit is for you who need an extra layer of confidence before a complete transition to Bonds Bio 3D human mature organoids. We provide our organoids in 96- and 384-well plates, with individual organoids per well, an outstanding source of unique feature samples for your testing, allowing for mid-to-large scale analysis and compatible with the most common high-throughput systems available in the market. Our models are validated using cells from healthy donors (commercially available now) and Patient-Derived Organoids (PDOs) with samples from different ages, races, BMI index, and diseases (e.g., Type 2 diabetes, cancers). (For more information on our PDO line, contact us). COMING SOON… In addition to the human adult SVF-derived adipose tissue models, we are developing outstanding Adipose Tissue and Heart 3D human models derived from human-induced pluripotent stem cells (hiPSCs). We are now differentiating hiPSCs into subcutaneous, visceral, and beige-like adipocytes to assemble the next generation of Bonds Bio 3D human Adipose Tissue Organoids from hiPSCs. Last but not least, very soon, we will launch our hiPSC-derived Heart spheroids and Heart Organoids for you to test drugs cardiotoxicity and cardiovascular diseases in two outstanding platforms, more sensitive than their 2D peers and less complicated to handle than engineered-heart tissues (EHTs). Your heart will "beat faster" with Bonds Bio 3D Heart models (For more information on our Cardio line, contact us). ABOUT OUR COMPANY The development of human physiologically relevant 3D organoids is made more accessible with Bonds Biosystems. Our Mission is to turn INNOVATIVE science into more accurate and affordable therapies for patients worldwide through In VITRO 3D solutions, envisioning the creation of technologies that accelerate drug development, enhancing new therapies' efficacy to bring new HOPES to humankind, preferably reducing costs and reducing or even avoiding the need for animal models use. If you want to be a part of this revolution of in vitro biology, do not hesitate to contact us at bondsbio.com/contact We are looking forward to helping you to transform your 3D experience!

Zub lane 65 Gardner, MA, 01440 United StatesBiosynth is an innovative global life sciences reagents, custom synthesis, and manufacturing services company that secures the fragment pharma and diagnostic supply chain. With an unrivaled research product portfolio and end-to-end manufacturing services, Biosynth is science-led and customer-focused on solving problems and delivering key reagents at scale and with quality. Our expertise and capability runs across fine chemicals/small molecules, peptides and key biologics all from one trusted partner. We manufacture and source a vast range of chemical and biochemical products, and take pride in delivering products that others cannot. We provide a full range of products and services to support life science research and development, with more than a million products in our research catalog and many hundreds of complex manufacturing service projects. Our small molecule chemistry specialties include enzyme substrates, carbohydrate and nucleoside chemistry, as well as intermediates, APIs and controlled substances. Customers can partner across the full product life cycle with no need to change suppliers, with manufacturing services from the first idea to the finished product, from route scouting and optimization to GMP or ton-scale production at sites across Europe and Asia. Biosynth’s peptide division, based in the US and Europe, has over 40 years of expertise in assisting pharma and diagnostics customers and specializes in custom peptide synthesis from nmol up to multiKg scale. From peptide discovery and lead optimization, including our own CLIPS™ technology to lock peptides into active conformations, to GMP NCEs and neoantigens to cover all your needs. Biosynth has a synergistic offering of critical biological raw materials, including mono- and polyclonal antibody production and our unique epitope mapping service as a platform to support your antibody development, including patent applications. Biosynth’s enzyme products and solutions are at the forefront of biocatalysis and also include custom enzyme development and production. Through the Biosynth group, we also offer the development of antibodies, antigens, and supply of plasma for in vitro diagnostics. *Biosynth and the Biosynth Group includes the previous and associated brands: Carbosynth, vivitide, New England Peptide, Peptides International, Pepscan, Eucodis Bioscience, Aalto Bio Reagents, Fitzgerald Industries International, Cambridge Research Biochemicals (CRB) & Celares For more information please visit our website: https://www.biosynth.com/

12 Michigan Drive Natick, MA, 01760 United StatesBeantown Biotech is a Contract Drug Discovery Research Organization offering Assay Development, High Throughput Screening and Lead Optimization. We offer a wide variety of in vitro and cell-based screening platforms. We promise rigorous science, open honest communication and timely data reporting. We are your laboratory “down-the-hall” and are dedicated to your scientific needs.

700 Technology Park Drive, Suite 204 Billerica, Massachusetts, 01821 United StatesBeantown Biotech is a Contract Drug Discovery Research Organization offering Assay Development, High Throughput Screening and Lead Optimization. We offer a wide variety of in vitro and cell-based screening platforms. We promise rigorous science, open honest communication and timely data reporting. We are your laboratory “down-the-hall” and are dedicated to your scientific needs.

12 Michigan Drive Natick, MA, 01760 United StatesBeantown Biotech is a Contract Drug Discovery Research Organization offering Assay Development, High Throughput Screening and Lead Optimization. We offer a wide variety of in vitro and cell-based screening platforms. We promise rigorous science, open honest communication and timely data reporting. We are your laboratory “down-the-hall” and are dedicated to your scientific needs.

151 Martine Street Fall River MA 02723Boston 3T Biotech is a research company focused on delivering values to biologists in the academia, pharmaceutical and biotechnology industries. We pride ourselves in providing best products and services to our customers so they can focus on fundamental questions in drug discoveries and biology researches. Our office and labs are located at the Entrepreneur and Innovation Center (?), University of Massachusetts, Dartmouth. Our facilities include a cell culture lab, a molecular biology/assay testing lab, freezers, and storage areas. B3T also has access to shared animal facilities at the Umass Dartmouth, other core facilities such as chemical labs and bioprocess labs. We offer free consulting for protein expression strategies and protein engineering designs to meet specific needs. Our goal to facilitate early stage discovery or development projects for protein/antibody therapeutics. Together, we have over 30 years of experiences in servicing therapeutic discovery and antibody development projects. We work with client to focus on the project scope and requirement, and establish deliverables for your discovery or development projects. We only charge for set-up fees if the protein expression was not successful. We have extensive experiences helping client to develop expression strategies and IP positions.

151 Martine St Fall River, MA, 02723 United StatesBoston 3T Biotech is a research company focused on delivering values to biologists in the academia, pharmaceutical and biotechnology industries. We pride ourselves in providing best products and services to our customers so they can focus on fundamental questions in drug discoveries and biology researches. Our office and labs are located at the Entrepreneur and Innovation Center (?), University of Massachusetts, Dartmouth. Our facilities include a cell culture lab, a molecular biology/assay testing lab, freezers, and storage areas. B3T also has access to shared animal facilities at the Umass Dartmouth, other core facilities such as chemical labs and bioprocess labs. We offer free consulting for protein expression strategies and protein engineering designs to meet specific needs. Our goal to facilitate early stage discovery or development projects for protein/antibody therapeutics. Together, we have over 30 years of experiences in servicing therapeutic discovery and antibody development projects. We work with client to focus on the project scope and requirement, and establish deliverables for your discovery or development projects. We only charge for set-up fees if the protein expression was not successful. We have extensive experiences helping client to develop expression strategies and IP positions.

225 Turnpike Road Southborough, MA, 01772 United StatesOur mission is to be a trustable partner to our clients by delivering robust bioprocess solutions on time. BIB is dedicated to building up long-term strategic partnerships with the clients. We value the success of our clients as our success, and stand by our clients along with his way to the success. *Strain & Cell Line Development* BIB provides strain and cell line development services with high throughput technologies to support our clients with accurate and high standard of quality. *Microbial Fermentation & Cell Culture Development* Aiming to achieve high cell density, high titer and high product quality, BIB can quickly develop a robust fermentation or cell culture process to support our clients. *Recovery & Purification Development* With broad experience, BIB provides quick primary recovery and purification process development to meet the requirement of our clients. *Analytical Services* Whether you are looking for assay development or assay support for fermentation, cell culture and purification development, you can always count on BIB as your development partner. *Process Characterization* BIB can provide our customer with a deep understanding of the whole bioprocess through PC study to obtain effective and robust process control strategy. *Materials Supply & Technology Support* BIB offers technology solutions and material supplies to support on-time delivery to our client to enhance the living quality of the patients and their families.

222 Maple Ave. Rose Gordon Building Rm 121 Shrewsbury, Massachusetts, 01545 United StatesBiotech focusing on nanotech for drug delivery

222 Maple Ave. Rose Gordon Building Rm 121 Shrewsbury, Massachusetts, 01545 United StatesBiotech focusing on nanotech for drug delivery

Cambridge, MA United StatesCerulean specializes in nanopharmaceutical services.

Westwood, MA United StatesCompuCyte offers software and technologies to support cytometry services including cell cycle analysis, apoptosis, tissue microarrya analysis, and immunophenotyping.

385 University Avenue Westwood, MA 02090 USACompuCyte offers software and technologies to support cytometry services including cell cycle analysis, apoptosis, tissue microarrya analysis, and immunophenotyping.

675 Massachusetts Ave. Cambridge, MA 02139 USACytel offers clinical research services and software to support clinical trial design and implementation.

460 Totten Pond Road Waltham, MA, 02451 United StatesCytel offers clinical research services and software to support clinical trial design and implementation.

200 Corporate Place, Suite #7 Peabody, MA 01960 USAConVerge Diagnostic Services offers clinical laboratory testing capabilities including cytology, flow cytometry, histology, and clinical pathology.

275 Washington Street Newton, MA, 02458 United States

303 Wyman St. Suite 300 Waltham, Ma, 01742 United States

245 First Street, Suite 1826 Cambridge Massachusetts 02142 USACLC Bio provides bioinformatics and sequencing services.

111 Durfee Street Fall River, MA 02720, USACreapharm-MP5 offers cytotoxics, high potency products, protein, antibody, and manufacturing services.

1100 Winter Street Waltham, MA 02451-1427Cato Research provides clinical trials, regulatory services, pharmacovigilance, CMC, and quality assurance.

177 Huntington Ave Suite 1703 PMB 23928 Boston, MA, 02109 United StatesAt Centaur Labs, we help AI developers make use of healthcare data. Our scalable and high quality data annotation platform continuously measures the accuracy of data annotators, whose annotation quality is motivated by pay-for-performance incentives, and optimized by collective intelligence.

65 Parker Street Unit 11 Newburyport, MA, 01950 United StatesCell Sciences offers recombinant cytokine, cytokine receptors, kinase, phosphatase, ELISA, antibody and assay services.

14 Gill St Woburn, MA, 01801 United StatesCovaris supplies sample prep instruments for DNA Shearing, accessories, and consumables in addition to offering shearing and extraction services.

14 Gill Street Unit H Woburn, MA, 01801 United StatesCovaris supplies sample prep instruments for DNA Shearing, accessories, and consumables in addition to offering shearing and extraction services.

3 Trask Lane United States Danvers, MA, 01923 United StatesDoing good science is important. So is just doing good. Cell Signaling Technology (CST) is a different kind of life sciences company—one founded, owned, and run by active research scientists, with the highest standards of product and service quality, technological innovation, and scientific rigor for over 20 years. We consistently provide fellow scientists around the globe with best-in-class products and services to fuel their quests for discovery. Helping researchers find new solutions is our main mission every day—but it's not our only mission. We're also dedicated to helping identify solutions to other problems facing our world. We believe that all businesses must be responsible and work in partnership with local communities, while seeking to minimize their environmental impact. That's why we joined 1% for the Planet as its first life science member, and have committed to achieving net-zero emissions by 2029. At CST, we believe in the power and promise of science to solve the challenges we face as a global community. We're a company of caring people driven by a devotion to facilitating good science—a company committed to doing the right thing for our Customers, our communities, and our planet.

470 Wildwood Avenue Woburn, MA, 01801 United StatesCephrim Biosciences is a preclinical contract research organization specializing in high quality yet cost-effective pharmacological profiling of small molecule compounds and biologicals in small animal models. We offer pharmacological screening services to help identify lead compounds for future development and preclinical assessment of toxicology and safety. Selected lead compounds can then be analyzed in more sophisticated animal disease models to establish in vivo proof-of-principle. Disease models in the areas of cancer, inflammatory diseases and neurology are currently available for efficacy testing and the analysis of biomarkers. If requested, further optimization of dosing, scheduling, and formulation can also be performed. Cephrim Biosciences’ business model is to provide our clients in the biotech and pharmaceutical industry with access to state-of-the-art pharmacological expertise and pre-clinical testing services. Our mission is to deliver high-quality research results that can be used to assess the potential of each drug for clinical success. We are especially committed to offer our clients a personalized approach to the design of their pharmacological studies, and we work closely with our clients when selecting the optimal animal models and study parameters to ensure that each study delivers the highest value for future decision making. We provide continuous updates for ongoing studies, and take great care to complete studies on time and within the specified budget.

470 WILDWOOD AVE, UNIT 1 United States Woburn, MA, 01801 United StatesCephrim Biosciences is a preclinical contract research organization specializing in high quality yet cost-effective pharmacological profiling of small molecule compounds and biologicals in small animal models. We offer pharmacological screening services to help identify lead compounds for future development and preclinical assessment of toxicology and safety. Selected lead compounds can then be analyzed in more sophisticated animal disease models to establish in vivo proof-of-principle. Disease models in the areas of cancer, inflammatory diseases and neurology are currently available for efficacy testing and the analysis of biomarkers. If requested, further optimization of dosing, scheduling, and formulation can also be performed. Cephrim Biosciences’ business model is to provide our clients in the biotech and pharmaceutical industry with access to state-of-the-art pharmacological expertise and pre-clinical testing services. Our mission is to deliver high-quality research results that can be used to assess the potential of each drug for clinical success. We are especially committed to offer our clients a personalized approach to the design of their pharmacological studies, and we work closely with our clients when selecting the optimal animal models and study parameters to ensure that each study delivers the highest value for future decision making. We provide continuous updates for ongoing studies, and take great care to complete studies on time and within the specified budget.

1900 West Park Drive Suite 280 Westborough, MA, 01581 United StatesBy bringing together modern label-free technology, application development know-how and sophisticated software, Creoptix offers a unique optical biosensor tool for binding kinetics. Engineered around our proprietary Grating-Coupled Interferometry (GCI) technology, the Creoptix WAVEsystem delivers high-quality kinetic data across a broader range of samples than traditional SPR equipment.

501 Boylston Street Boston, MA, 02116 United StatesConcertAI is a global leader in precision oncology, integrating AI technology, and real-world evidence (RWE) software-as-a-service (SAAS) solutions for life science companies, healthcare providers and medical societies. ConcertAI’s mission is to accelerate insights and outcomes for patients through leading real-world data (RWD), AI solutions and scientific expertise for oncology hematology and urology. ConcertAI’s advanced research-grade RWD and analytic technologies support decision-making across drug development, clinical trials, precision oncology, visualization, imaging, clinical decision support and evidence-driven patient care.

1120 Massachusetts Avenue Cambridge, MA, 02138 United StatesConcertAI is a global leader in precision oncology, integrating AI technology, and real-world evidence (RWE) software-as-a-service (SAAS) solutions for life science companies, healthcare providers and medical societies. ConcertAI’s mission is to accelerate insights and outcomes for patients through leading real-world data (RWD), AI solutions and scientific expertise for oncology hematology and urology. ConcertAI’s advanced research-grade RWD and analytic technologies support decision-making across drug development, clinical trials, precision oncology, visualization, imaging, clinical decision support and evidence-driven patient care.

75 Kneeland Street Boston, MA, 02111 United StatesCell Essentials offers cell culture, antibody production, cell line creation, assay development, and peptide synthesis.

1440 Main St Suite 310 Waltham, Massachusetts, 02451 United StatesCorEvitas, LLC is a science-led data intelligence company that provides the life sciences industry with the objective data and clinical insights needed to bring safe, effective treatments to market. We are the built-for-purpose provider of gold-standard real world evidence. Clinical Registries Our patient registries track information about the health status of patients and the care they receive. They bring together large data sets and analyze patterns in treatments and outcomes to inform best practices and treatment decisions. We provide high quality, customized, registry-based post-authorization safety studies and pharmacovigilance reporting activities to address regulatory needs. Patient Powered Registries We work closely with our clients to develop fit-for-purpose, patient-centered, observational registries. Our patient-level datasets can be licensed to leverage directly or linked to other acquired datasets, including claims and EMR, to generate deeper clinical insights. Pregnancy Registries and Studies Fulfill regulatory-mandated pregnancy registries, leveraging robust sample sizes, personalized data collection, access to real-time participants’ data, end-to-end system security protocols, and concierge participant engagement. Conduct observational and large claims-based pregnancy studies. Patient Experience We use a systematic, evidence-based process to help pharmaceutical clients spearhead patient engagement initiatives, including patient communities, long-term patient panels, clinical trial simulation and awareness, surveys, medical communications, and more. Human Biospecimens We pair our deep, rich, longitudinal registry data with select biospecimens for use in the advancement of the molecular understanding of disease and development of novel therapeutics, diagnostics, and prognostic tools. Sample types include DNA/RNA, serum, and plasma from these auto-immune indications: Rheumatoid Arthritis, Multiple Sclerosis, IBD, Psoriasis, Neuromyelitis optica spectrum disorder (NMOSD), Lupus, Ankylosing Spondylitis. Specialty EMR Data CorEvitas’ leading suite of innovative, real-world evidence services utilizes US retinal EMR and US claims data, as well as European and UK primary and secondary care datasets. These resources allow us to provide a wide range of health utilization analytics, market insight, and market access reports, as well as comparator studies across multiple markets.

300 5th Ave Suite 3020 Waltham, MA, 02451 United StatesCorEvitas, LLC is a science-led data intelligence company that provides the life sciences industry with the objective data and clinical insights needed to bring safe, effective treatments to market. We are the built-for-purpose provider of gold-standard real world evidence. Clinical Registries Our patient registries track information about the health status of patients and the care they receive. They bring together large data sets and analyze patterns in treatments and outcomes to inform best practices and treatment decisions. We provide high quality, customized, registry-based post-authorization safety studies and pharmacovigilance reporting activities to address regulatory needs. Patient Powered Registries We work closely with our clients to develop fit-for-purpose, patient-centered, observational registries. Our patient-level datasets can be licensed to leverage directly or linked to other acquired datasets, including claims and EMR, to generate deeper clinical insights. Pregnancy Registries and Studies Fulfill regulatory-mandated pregnancy registries, leveraging robust sample sizes, personalized data collection, access to real-time participants’ data, end-to-end system security protocols, and concierge participant engagement. Conduct observational and large claims-based pregnancy studies. Patient Experience We use a systematic, evidence-based process to help pharmaceutical clients spearhead patient engagement initiatives, including patient communities, long-term patient panels, clinical trial simulation and awareness, surveys, medical communications, and more. Human Biospecimens We pair our deep, rich, longitudinal registry data with select biospecimens for use in the advancement of the molecular understanding of disease and development of novel therapeutics, diagnostics, and prognostic tools. Sample types include DNA/RNA, serum, and plasma from these auto-immune indications: Rheumatoid Arthritis, Multiple Sclerosis, IBD, Psoriasis, Neuromyelitis optica spectrum disorder (NMOSD), Lupus, Ankylosing Spondylitis. Specialty EMR Data CorEvitas’ leading suite of innovative, real-world evidence services utilizes US retinal EMR and US claims data, as well as European and UK primary and secondary care datasets. These resources allow us to provide a wide range of health utilization analytics, market insight, and market access reports, as well as comparator studies across multiple markets.

209 West Central Street Suite 307 Natick, MA, 01760 United StatesCarna Biosciences, a biotechnology company focusing on kinases as the important targets for the development of drugs to treat a variety of diseases, including cancer, inflammation, and neurological disorders, offers a wide range of kinase protein products all developed and manufactured in-house and assay services with extensive kinase targets for your research and development. Our biochemical assay services are boast of delivering highly reproducible quality data by employing only our in-house kinases which have passed our stringent QC and conducting experiments under the thoroughly managed assay system by skilled hands. Our cell-based assays which investigate your compounds’ binding activities generate reliable data utilizing the well-established Promega’s NanoBRET™ technology. In addition to these kinase products and services, our rich experiences, deep knowledge, and know-how in drug discovery targeting kinases will give you unparalleled support which surely helps accelerate your drug discovery. If you are engaged in kinase inhibitor research and development, Carna Biosciences will be your best support partner.

209 W Central St Ste #307 Natick, MA, 01760 United StatesCarna Biosciences, a biotechnology company focusing on kinases as the important targets for the development of drugs to treat a variety of diseases, including cancer, inflammation, and neurological disorders, offers a wide range of kinase protein products all developed and manufactured in-house and assay services with extensive kinase targets for your research and development. Our biochemical assay services are boast of delivering highly reproducible quality data by employing only our in-house kinases which have passed our stringent QC and conducting experiments under the thoroughly managed assay system by skilled hands. Our cell-based assays which investigate your compounds’ binding activities generate reliable data utilizing the well-established Promega’s NanoBRET™ technology. In addition to these kinase products and services, our rich experiences, deep knowledge, and know-how in drug discovery targeting kinases will give you unparalleled support which surely helps accelerate your drug discovery. If you are engaged in kinase inhibitor research and development, Carna Biosciences will be your best support partner.

500 Shire Way Lexington, Massachusetts, 02421 United StatesCBSET offers regulatory consulting, imaging, drug testing, pathology, kinetic models, and morphometric analysis.

205 Lowell Street Wilmington, MA, 01887 United StatesCuriRx Inc is a Contract Research and Product Development Services Company CuriRx offers Bioprocess -upstream up to 40 liter bioreactors and fermentation and downstream purification development High resolution Mass Spectroscopy - CMC characterization- Curilytics. Analytical method development, GMP stability studies, support analytical testing, in-use stability studies, photo-stability, protein characterization, bio chemical and bio physical methods and characterization, GMP testing services Preformulation, Formulation and lyophilization development for small and large molecules, non-viral vectors and viral vectors Injectables-IV, IM, SC, IT, ocular, high concentration antibodies, bi-specific antibodies, peptide, proteins and enzymes, microbiomes Robustness and forced degradation studies Encapsulation, micro and nano formulations Emulsions, micro and nano emulsions

205 Lowell Street Wilmington, MA, 01887 United StatesCuriRx Inc is a Contract Research and Product Development Services Company CuriRx offers Bioprocess -upstream up to 40 liter bioreactors and fermentation and downstream purification development High resolution Mass Spectroscopy - CMC characterization- Curilytics. Analytical method development, GMP stability studies, support analytical testing, in-use stability studies, photo-stability, protein characterization, bio chemical and bio physical methods and characterization, GMP testing services Preformulation, Formulation and lyophilization development for small and large molecules, non-viral vectors and viral vectors Injectables-IV, IM, SC, IT, ocular, high concentration antibodies, bi-specific antibodies, peptide, proteins and enzymes, microbiomes Robustness and forced degradation studies Encapsulation, micro and nano formulations Emulsions, micro and nano emulsions

Woburn, MA United StatesCourtagen Life Sciences provides innovative and disruptive proteomic and genomic products and services to the Life Sciences industry.

12 Gill Street, Suite 3700 Woburn, MA 01801 USACourtagen Life Sciences provides innovative and disruptive proteomic and genomic products and services to the Life Sciences industry.

12 Lagemann Ln, Chilmark, MA 02535The Chilmark Coffee Company is part of a small island community; a collaboration between farmers and fisherman, summer intellectuals and world economic leaders, photographers and painters, poets and stone masons, tradesmen and master craftsmen, elderly and young - All working closely to continue the values and slow pace established generations ago on this glacial moraine in the Atlantic Ocean. People here make things slowly and with pride. They understand and live as part of this unique environment.

Barnstable, MA, 02601 United StatesCape Cod Clinical Research, Inc.(CCCRi) provides auditing, monitoring, and staff development.

Newton, MA, USAClinical Data is a biotechnology company developing early and late stage targeted therapeutics as well as genetic and pharmacogenomic tests that detect serious diseases and help predict drug safety, tolerability and efficacy.

1 College Street Worcester, MA, 01610 United StatesFrom academics and athletics to opportunities for spiritual development, the Holy Cross undergraduate experience is among the best in the nation — preparing students for fulfilling leadership roles in every aspect of life.

1 College Street, Worcester, MA 01610From academics and athletics to opportunities for spiritual development, the Holy Cross undergraduate experience is among the best in the nation — preparing students for fulfilling leadership roles in every aspect of life.

One Kendall Square Suite B2101 Cambridge MA 02139 USACancer Research Technology offers translational development and commercialization with its primary focus on cancer.

39 Spruce Street East Longmeadow, MA 01028Established in 1984, Con-Test, Inc. was founded by Thomas and Kathleen Veratti and provided environmental consulting and testing services to a variety of clients throughout western Massachusetts. Initially, our laboratory testing division was limited to Industrial Hygiene analysis mainly in support of in-house consulting services. But, we rapidly expanded our capabilities to include numerous techniques in air analysis, classical (wet) chemistry, metals, and organics. In 1994, Con-Test was purchased by ATC Associates, Inc. Two years later, the Laboratory Division of the company was purchased by the original owners and became what we are known as today: Con-Test Analytical Laboratory. Con-Test became a privately-owned, independent laboratory and grew enormously to our current state. We are proud to have established a reputation based on quality, integrity, and reliability within the environmental industry. Our dual facilities house over twenty seasoned analysts with exceptional knowledge of their field of work. We have invested millions of dollars in state-of-the-art equipment and are always looking for innovative technological advances that will help us to provide the best services to you. Con-Test provides environmental and industrial hygiene analytical services with full AIHA-LAP, LLC and AIHA-LAP, LLC ELLAP (Environmental Lead) accreditation. We have obtained the nationally recognized NELAP certification and are individually certified in many areas and states by a diverse group of recognized organizations. To learn more about our certifications, please visit our Certifications page. Capabilities Con-Test has the capability for analyzing nearly all water, air, soil and solid materials. Our laboratory currently serves a diverse range of clients with an even larger range of analytical services. We can handle projects from one sample to thousands of samples, and can offer rush services at any time. Our laboratory experts are available for consultations, presentations, technical support and advice. Browse through our website or contact us for more information about our capabilities. What is the Con-Test Difference? Every day, our employees come to work with one focus in mind: our clients. We are here to focus on you and your business, with the goal of making the environment a better place to live. Through building relationships based upon quality and integrity, we believe our clients will understand the benefits of working with an established small business. Our team of professionals is ready at all times to accommodate your demands and needs, while striving for the highest level of professionalism and quality in our work. We go above-and-beyond for our clients every day by providing exceptional technical support, rapid turnaround time, and the desire to help in any way we can. Con-Test welcomes you to learn more about us by looking through our website and contacting us with any questions you may have. Discover the Con-Test Difference. You will be glad you did.

100 Barber Avenue Worcester, MA 01606 USACellMosaic specializes in the analysis and purification of biomolecules and their bioconjugates.

63 Great Road Maynard MA 01754 USACHI Scientific provides peptides services, protein expression, antibody production, DNA services, cell culture, and siRNA services.

Two Shaker Road, Suite C200 Shirley, MA 01464 USACELLTREAT Scientific Products offers 3D cell culture and tissue products and equipment.

65 Hayden Avenue Lexington, MA, 02421 United StatesCubist Pharmaceuticals is a bio-pharmaceutical company focused on the research, commercial­ization and creation of pharmaceutical products that address unmet medical needs in the acute care environment.

Cambridge Innovation Center One Broadway, 14th Floor Cambridge, MA 02142In 2011, NASA chose the Center for the Advancement of Science in Space (CASIS) to be the sole manager of the International Space Station U.S. National Laboratory. The mission of CASIS is to maximize use of this unparalleled platform for innovation, which can benefit all humankind and inspire a new generation to look to the stars. The organization has been awarded by NASA the responsibility of inciting the imagination of entrepreneurs and scientists alike, accelerating and facilitating space-based research as well as creating public awareness of National Lab research and making space science more accessible to the world. By carefully selecting research and funding projects, by connecting investors looking for opportunity to scientists with great ideas, and by making access to the station faster and easier, CASIS will drive scientific inquiry toward developing groundbreaking new technologies and products that will tangibly affect our lives.

927 Currant Rd, Fall River, MA USA 02720Exemplar Pharma provides development of nasal and inhalation products.

659 Andover Street Lawrence, MA 01843-1032 USAAfter developing the world’s first rapid test for antibiotics in milk in 1978, Charm Sciences has grown to become a leading global provider of food safety, water quality and environmental diagnostics equipment. Charm’s portfolio includes test kits and systems for antibiotics, mycotoxins, and sanitation/hygiene (ATP). Selling directly and through its network of distributors, Charm products serve the dairy, feed & grain, food & beverage, water, healthcare, environmental, and industrial markets in more than 90 countries. Customers rely on Charm products for excellence in quality, innovation and customer support.

480 Neponset Street Building 7 Canton MA 02021 USAChemic Laboratories is FDA registered and DEA licensed and provides cGMP/GLP analytical testing services including but not limited to the following: methods development and validations, QC testing, bioanalytical services, extractables and leachables testing, ICH stability/storage and organic synthesis and formulations development.

65 Sycamore Rd. Wayland, MA, 01778 United StatesCell Assay Innovations is a CRO that provides biological services related to drug discovery, with a focus on assay development, compound screening, and the detection and profiling of post-translational modifications.

100 Cummings Center, Suite 424J Beverly, MA 01915 USACell Assay Innovations is a CRO that provides biological services related to drug discovery, with a focus on assay development, compound screening, and the detection and profiling of post-translational modifications.

3 Highwood Drive Tewksbury, MA, 01876 United StatesCIL specializes in the development and production of stable (non-radioactive) isotopes and chemical compounds labeled with stable isotopes.

50 Frontage Road Andover MA 01810CIL specializes in the development and production of stable (non-radioactive) isotopes and chemical compounds labeled with stable isotopes.

33 Industrial Way Wilmington, MA, 01887 United StatesChemGenes provides DNA synthesis, DNA sequencing, and analysis.

Agawam, MA United StatesClinical Research Management provides clinical research associates, clinical support, project management, and drug storage.

18 Industrial Rd. Walpole, MA 02081

199 Dexter Avenue Watertown, MA 02472 USACambridge Scientific Products offers laboratory equipment and supplies.

99 Hayden Avenue Lexington, MA, 02421 United StatesConcert Pharmaceuticals is a clinical stage biopharmaceutical company. We apply our extensive knowledge of deuterium chemistry to discover and develop novel small molecule drugs.

Cardiovascular Clinical Studies, Inc. 75 Kneeland Street Boston, MA 02111Cardiovascular Clinical Trials (CCS) provides clinical development, site management, safety reporting, and pharmacoeconomic studies.

Riverside Technology Center 840 Memorial Drive, Suite 101 Cambridge, MA 02139

Charter Preclinical Services Hudson, MA

PO Box 540 Brookline, MA 02446 USAThe Conditas Biotechnology Group is dedicated to the successful, efficient, and cost-effective execution of outsourced projects and programs in discovery, development, and commercialization of small molecules, biologics and bioconjugates.

215 First Street Cambridge, MA, 02142 United StatesConstellation Pharmaceuticals leverages insights from the rapidly expanding field of epigenetics to discover and develop small molecule therapeutics for the treatment of cancer, inflammatory/immunologic disorders and other diseases.

100 CambridgePark Drive Cambridge, MA 02140 USACambridgeSoft offers software for laboratory informatics.

29 Everett Street Holliston, MA 01746 USACold Chain Technologies (CCT) provides insulated thermal packaging solutions that protect the integrity of temperature sensitive products.

One Kendall Square Suite 2203, Bldg 200 Cambridge, MA 02139Cambridge Biolabs (CBL) is your hit-the-ground-running, local, contract research organization serving the Boston Innovation Supercluster from our convenient Kendall Square location. Our clients are start-up biotechnology companies and venture capitalists who need their scientists to get started producing results immediately. We know it can take months to find and build out a lab; our team has been through this many times. CBL now offers wet-bench laboratory space for molecular, cellular and microbiology including a cell culture suite and numerous regional partnerships for in vivo work and specialized core capability. Our team brings experience and expertise to the table that will complement your know-how and ability. Our scientists are ready to start moving your company or investment toward important milestones immediately.

29 Everett Street, Holliston, MA 01746Cold Chain Technologies, Inc. (CCT) is a global leader in the development and delivery of cost-effective insulated thermal packaging solutions that protect the integrity of temperature sensitive products. With more than 45 years of experience in the cold chain, we understand its logistics and applications, its demands and its extremes. When you partner with Cold Chain Technologies, you benefit from: Reliable, cost-effective performance Proven, real world designs Unrivaled engineering expertise Total support of your cold chain needs

950 MAIN STREET, WORCESTER MA 01610 508-793-7711Clark is a university on the cutting edge of higher education. A liberal arts-based research university with a distinguished academic and research pedigree, Clark is redefining higher education for the 21st century — forging robust partnerships that break down boundaries between academia and society, and more deeply attuning students’ learning experiences to the profound changes taking place in the world today. We're a national leader in cultivating an educational environment characterized by collaboration, creativity, intellectual daring, and the capacity and determination to bring about real, transformative global change.

23 Rainin Road Woburn, Massachusetts, 01801 United StatesCreaGen Biosciences offers medicinal chemistry, organic synthesis, exploratory chemistry, lead optimization, structure-based drug design, parallel synthesis, spectroscopy, and scale up.

23 Rainin Road Woburn Massachusettes 01801 USACreaGen Biosciences offers medicinal chemistry, organic synthesis, exploratory chemistry, lead optimization, structure-based drug design, parallel synthesis, spectroscopy, and scale up.

299 WASHINGTON ST Woburn, MA, 01801 United StatesCreaGen Biosciences offers medicinal chemistry, organic synthesis, exploratory chemistry, lead optimization, structure-based drug design, parallel synthesis, spectroscopy, and scale up.

214 Lincoln St. Suite 315 Allston, MA 02134 USAChimerigen Laboratories offers mouse fusion proteins, human fusion proteins, ELISA kits, and monoclonal antibodies for purchase in addition to custom protein production and purification services.

56 Roland Street Boston, MA, 02129 United StatesCambridge Polymer Group, Inc. ("CPG") is a contract research laboratory that specializes in providing polymeric materials services for clients worldwide. Headquartered in Boston, MA, our researchers are experts in a broad range of scientific fields, including chemical, electrical, biomedical and mechanical engineering, materials science, and biology. For over 17 years, we have provided a single source solution for polymeric research. CPG's core competencies include property enhancement, test methodology development, radiation chemistry, rheology, failure analysis and blends formulations. Our work can be found in a range of industries including biomedical, resin manufacturers and processors, consumer products, hydrogels, adhesives, food products, and inks. The services and products we offer range from full service consultation on material development to providing more traditional testing results. We have extensive experience in analysis of medical devices, and assist clients in extraction/leaching studies, aging studies, root cause analysis, and testing for regulatory submission with compliance to ISO, ASTM, and USP standards.

56 Roland St., Suite 310 Boston, MA 02129 USACambridge Polymer Group, Inc. ("CPG") is a contract research laboratory that specializes in providing polymeric materials services for clients worldwide. Headquartered in Boston, MA, our researchers are experts in a broad range of scientific fields, including chemical, electrical, biomedical and mechanical engineering, materials science, and biology. For over 17 years, we have provided a single source solution for polymeric research. CPG's core competencies include property enhancement, test methodology development, radiation chemistry, rheology, failure analysis and blends formulations. Our work can be found in a range of industries including biomedical, resin manufacturers and processors, consumer products, hydrogels, adhesives, food products, and inks. The services and products we offer range from full service consultation on material development to providing more traditional testing results. We have extensive experience in analysis of medical devices, and assist clients in extraction/leaching studies, aging studies, root cause analysis, and testing for regulatory submission with compliance to ISO, ASTM, and USP standards.

101 Federal Street Suite 1900 #10 Boston, MA 02110-1821 USAClinical Research Consulting provides clinical monitoring, project management, and clinical training.

500 Boylston St #1700 Boston, MA, 02116 United StatesCambridge Semantics Inc., The Smart Data Company®, is an enterprise analytics and data management software company. Our software, the Anzo Smart Data Platform®, allows IT departments and their business users to semantically link, analyze and manage diverse data whether internal or external, structured or unstructured, with speed, at big data scale and at the fraction of the implementation costs of using traditional approaches.

500 Boylston Street, Boston, MA 02116, USCambridge Semantics Inc., The Smart Data Company®, is an enterprise analytics and data management software company. Our software, the Anzo Smart Data Platform®, allows IT departments and their business users to semantically link, analyze and manage diverse data whether internal or external, structured or unstructured, with speed, at big data scale and at the fraction of the implementation costs of using traditional approaches.

485 Massachusetts Avenue Suite 300 Cambridge, MA 02139-4018 USACartagenia delivers diagnostic knowledge, systems and services to enable genetic labs and clinicians to perform clinically relevant genetic analyses quickly and efficiently, and offer patients and carers high quality genetic interpretation and counseling.

275 Grove St Ste 2-400 Auburndale, MA, 02466 United StatesCambrY Applied Biosciences is a biotech reagents and services company that specializes in the production of recombinant proteins from mammalian cells, monoclonal/polyclonal antibodies, and immunoassay kits, covering major research fields such as Virology, Oncology, and Immunology. The company also provides DNA services such as gene cloning, DNA synthesis, CRISPR DNA prep, plasmid prep, etc.

200 Clarendon Street Boston, MA, 02116 United StatesCharles River Associates (CRA) is a leading global consulting firm that offers economic, financial, and strategic expertise to major law firms, corporations, accounting firms, and governments around the world.

200 Clarendon Street Boston, MA, 02116 United StatesCharles River Associates (CRA) is a leading global consulting firm that offers economic, financial, and strategic expertise to major law firms, corporations, accounting firms, and governments around the world.

99A Erie Street Cambridge, MA, 02139 United StatesOur solution combines AI pattern recognition and whole-genome sequencing to provide rapid and specific detection of residual disease that is up to 100x more sensitive than competing technologies.

99A Erie Street Cambridge, MA, 02139 United StatesOur solution combines AI pattern recognition and whole-genome sequencing to provide rapid and specific detection of residual disease that is up to 100x more sensitive than competing technologies.

60 Thoreau Street, 294 Concord MA, US Concord, Massachusetts, 01742 United StatesCapeStart helps companies scale their AI innovation through data annotation, machine learning, and software development for the healthcare, telecom, financial services, retail and legal industries. Get a deeper level of secure enterprise AI through CapeStart’s integrated teams of seasoned data annotation, data science, and software development experts. CapeStart delivers custom, end-to-end AI solutions to help crush your business objectives and dominate the competition. No matter the complexity of your requirements, our highly experienced team has likely seen it before, solved it within our enterprise-grade secure infrastructure, and built the template – or can customize a solution just for you. Data scientists and engineers can also take advantage of our off-the-shelf and open source machine learning models and large datasets. Headquartered in Cambridge, MA, CapeStart’s dedicated, integrated team of subject matter and technical experts are located in Nagercoil in the Cape of India, serving 100-plus clients in more than 35 various industries.

1 Grant St Ste 230 Framingham, Massachusetts, 01702 United StatesA contract research organization (CRO) providing antibody discovery, recombinant antibody and protein production, and protein analytics service. Our services are high quality, fast, and affordable, allowing you to focus on your research.

1 Grant St Ste 230 Framingham, Massachusetts, 01702 United StatesA contract research organization (CRO) providing antibody discovery, recombinant antibody and protein production, and protein analytics service. Our services are high quality, fast, and affordable, allowing you to focus on your research.

150 New Boston Street Woburn, MA, 01801 United Statesfast, high quality NMR data acquisition services. 1H, 13C, 31P, 19F, 29Si, 11B, any other NMR active nuclei. 2D COSY, NOESY, HSQC, HMBC, ROESY, solvent suppression, protein-ligand binding studies. Solid state NMR.

150V NEW BOSTON ST Woburn, MA, 01801 United Statesfast, high quality NMR data acquisition services. 1H, 13C, 31P, 19F, 29Si, 11B, any other NMR active nuclei. 2D COSY, NOESY, HSQC, HMBC, ROESY, solvent suppression, protein-ligand binding studies. Solid state NMR.

25R Olympia Avenue Woburn, MA, 01801 United StatesCONTINUUS offers a breakthrough Integrated Continuous Manufacturing (ICM) solution for the manufacturing of small molecule drugs, providing advantages across the entire supply chain.

25R Olympia Avenue Woburn, MA, 01801 United StatesCONTINUUS offers a breakthrough Integrated Continuous Manufacturing (ICM) solution for the manufacturing of small molecule drugs, providing advantages across the entire supply chain.

201 Broadway Suite 301 Cambridge, MA, 02139 United StatesCertara® is the leading provider of decision support technology and consulting services for optimizing drug development and improving health outcomes. The company provides regulatory strategy, model-informed drug development services and technology, and regulatory writing and submission services. We offer a wide range of products, services and solutions that enable our clients to achieve key drug development, regulatory and commercial milestones. Our portfolio spans the discovery, preclinical, clinical and post-marketing phases of drug development, working with 1,200 commercial companies, 250 academic institutions and numerous regulatory agencies around the world.

313 Pleasant Street; 3rd Floor Watertown, MA, 02472 United StatesCyprotex, an Evotec company, has sites at Alderley Park near Macclesfield, UK and in Watertown near Boston, USA. The company has dedicated and highly qualified employees with proven experience in a wide range of specialist techniques acquired across diverse industries. The majority of our clients focus in pharmaceutical research, however, we also support clients in the chemical, cosmetics and personal care, agrichemical and tobacco industries. Cyprotex specialises in in vitro and in silico ADME-Tox services. This includes in vitro ADME screening to support discovery projects, regulatory in vitro ADME and DDI studies during preclinical and clinical development, specialist mechanistic in vitro human and animal toxicity models (e.g. 3D models and MEA electrophysiology) and PBPK/QSAR modelling expertise. As well as supporting clients directly, we have a strong focus on R&D and our scientists regularly present our findings at scientific conferences and through publications. In August 2017, Evotec acquired Aptuit in order to further expand the Group’s capabilities. As well as additional complementary drug discovery capabilities, Aptuit offers full CMC and IND-enabling services allowing the Evotec Group to provide expert support across the value chain from early discovery through to preclinical development and beyond

200 Staples Drive Framingham, MA, 01702 United StatesCyprotex, an Evotec company, has sites at Alderley Park near Macclesfield, UK and in Watertown near Boston, USA. The company has dedicated and highly qualified employees with proven experience in a wide range of specialist techniques acquired across diverse industries. The majority of our clients focus in pharmaceutical research, however, we also support clients in the chemical, cosmetics and personal care, agrichemical and tobacco industries. Cyprotex specialises in in vitro and in silico ADME-Tox services. This includes in vitro ADME screening to support discovery projects, regulatory in vitro ADME and DDI studies during preclinical and clinical development, specialist mechanistic in vitro human and animal toxicity models (e.g. 3D models and MEA electrophysiology) and PBPK/QSAR modelling expertise. As well as supporting clients directly, we have a strong focus on R&D and our scientists regularly present our findings at scientific conferences and through publications. In August 2017, Evotec acquired Aptuit in order to further expand the Group’s capabilities. As well as additional complementary drug discovery capabilities, Aptuit offers full CMC and IND-enabling services allowing the Evotec Group to provide expert support across the value chain from early discovery through to preclinical development and beyond

836 North Street Building 300 Tewksbury, MA, 01876 United States

6 Henshaw St. Woburn, MA, 01801 United States

6 Henshaw Street Woburn, MA, 01801 United States

235 Czeski Road Hardwick , MA, 01037-0356 United StatesOffers custom polyclonal antibody development services in goats, sheep, rabbits, chickens, llamas and alpacas for the research, diagnostic and pharmaceutical industries. Capralogics Inc. is also a supplier of several commercially available novel research antibody products.

235 Czeski Road, PO Box 356 Hardwick MA 01037 USAOffers custom polyclonal antibody development services in goats, sheep, rabbits, chickens, llamas and alpacas for the research, diagnostic and pharmaceutical industries. Capralogics Inc. is also a supplier of several commercially available novel research antibody products.

100 Franklin Suite 702 Boston, MA, 02110 United StatesA company founded on the development and commercialization of 3D Bioprinting products, CELLINK is now a "bioconvergence" company that designs cutting-edge instruments for automation of liquid-handling, single-cell dispensing, and other live-cell processes (imaging, -omics, etc.)

451 D St Suite 900 Boston , MA, 02210 United StatesA company founded on the development and commercialization of 3D Bioprinting products, CELLINK is now a "bioconvergence" company that designs cutting-edge instruments for automation of liquid-handling, single-cell dispensing, and other live-cell processes (imaging, -omics, etc.)

672 Suffolk Street Suite 300 Lowell, MA, 01854 United StatesProduct Offering: Human Immune Cells and Stem Cells -Leukopaks (RUO and GMP-compliant), mobilized leukopaks, mononuclear cells (PBMCs) (normal and irradiated), isolated immune cells, hematopoietic stem cells, antigen-specific T cells, antigens, bone marrow (RUO and GMP-compliant), cord blood, whole blood, plasma, serum, B-LCLs, mouse cells, and CryoStor™ and HypoThermosol™ biopreservation media. -Fresh and cryopreserved material -Offer a wide range of disease-state samples and matching healthy donor samples -Extensive recallable and characterized donor network -Onsite FDA-registered, GMP/GTP-compliant collection centers using IRB-approved protocols and informed consent forms. ACCELERATING YOUR RESEARCH WITH HIGH-QUALITY CELLULAR MATERIAL Charles River Cell Solutions, Inc., formerly (HemaCare and Cellero) is a global leader in the supply and customization of research (RUO) and GMP grade human-derived biological products and services. With 45+ years of experience in supplying blood and apheresis cellular products, Charles River Cell Solutions, Inc. is a leading provider of controlled, consistent, high quality, and purified human biological products and unprocessed cellular material. Our donor center sites, branded as HemaCare Donor Centers, are available coast-to-coast, with locations in California, Washington, Tennessee, and Massachusetts. With on-site FDA-registered, GMP/GTP-compliant collection centers, our scientists and operations staff provide expertise in cell processing and isolation, and superior cold chain management, to meet the specific program needs for autologous and allogeneic cell and gene therapy developers. Combined with Charles River’s greater cell and gene therapy services that include discovery services, research models, safety assessment, CDMO manufacturing, and testing services, our clients are well positioned to advance their cell and gene therapy programs. For more information, please visit https://www.criver.com/products-services/cell-sourcing

12 Gill Street Suite 4850 Woburn, MA, 01801 United StatesCovalX offers a complete solution for the full characterization of biotherapeutics. Our company is a leader in protein interaction analysis by mass spectrometry taking benefits of its unit technology platform (Epitope mapping HDX-MS and XL-MS; aggregation analysis, protein complex stoechiometry, cmpds/target interactions, SPR affinity analysis) . CovalX is offering all the analytical services for the characterization of your biotherapeutics: Denovo sequencing, LC-MS, MALDI-MS, Glycans characterization and the complementary analysis for the preparation of IND subimission following ICH-Q6B guidlines.

Floor 16, 175 Federal St Boston, MA, 02110 United StatesCostello Medical provides scientific support to the healthcare industry in the analysis, interpretation and communication of clinical and health economic data. Our technical expertise spans medical education, advisory boards, value materials, scientific writing, publication planning, evidence development, statistics, health economic modelling and health technology assessment; a full description of what we offer can be found on our website. Due to growing demand across an increasing range of service offerings and geographies, Costello Medical has grown organically since foundation in 2008 to a team of approximately 400 based in Cambridge, London, Manchester, Bristol, Boston and Singapore. Alongside our widening technical and creative capabilities, we remain committed to our core values of high-quality scientific work coupled with excellent customer service at competitive and transparent prices. Our talented team has experience with a variety of leading pharmaceutical companies and a track record of success in a broad range of disease areas.

11 Audubon Road Wakefield, MA, 01880 United StatesCellaria’s in vitro patient- matched cancer cell models are derived directly from patient tumors to reflect the unique nature and complexity of each patient’s disease. Our models are traceable back to initial patient tumor and clinical conditions, simplifying the analysis of patient-specific responses. Also providing stem cell preprogramming.

9 Audubon Road Wakefield, MA, 01880 United StatesCellaria’s in vitro patient- matched cancer cell models are derived directly from patient tumors to reflect the unique nature and complexity of each patient’s disease. Our models are traceable back to initial patient tumor and clinical conditions, simplifying the analysis of patient-specific responses. Also providing stem cell preprogramming.

3 Biotech, One Innovation Drive Worcester, MA, 01605 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

251 Ballardvale Street Wilmington, MA, 01887 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

251 Ballardvale Street Wilmington, MA, 01887 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

334 South Street Shrewsbury, MA, 01545 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

111 Huntington Ave Suite 2600 Boston, MA, 02199 United StatesFor over 75 years, Charles River has provided essential products and services to help pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe, helping to accelerate their research and drug development efforts. With over 90 sites globally, we’re ready to tackle your product’s most unique challenges. Our focus on timeliness and accuracy in every stage of drug development means you can count on us to deliver reliable results – every step of the way. Visit our website to learn more about our portfolio and how we can support your research. www.criver.com

25 New Chardon Street Boston, MA, 02114 United States

40 Maple Ave South Lancaster, MA, 01561 USADaVinci provides animal models, pharmacology, toxicology, efficacy studies, and preclinical testing of medical devices.

539 North Road Westfield, Ma 01085 USADion Label Printing specializes in printing pressure sensitive labels, tags, shrink sleeves, tickets and specialty applications for multiple industries.

450 Brookline Avenue Boston, MA, 02215 United States

26 Ivaloo St Somerville, Massachusetts, 02143 United StatesWe partner with fast-moving biotech and pharmaceutical companies to drive innovation through computational biology. We can be your one-stop shop for experimental design and data analysis. Or we can tailor custom solutions for your biggest challenges. We’ll collaborate with you to solve your biggest bioinformatics challenges hand-in-hand. Our highly trained consultants, all of whom have advanced degrees in the life sciences, work with you to leverage new bioinformatics and statistics techniques that can help you leapfrog the competition. We don’t just hand you the results — we help you understand them. * Actionable insights, not just data * A faster innovation cycle * Bleeding-edge approaches Advising and strategy: From design review to total bioinformatics department replacement, no problem is too small or big. Data analysis: Machine learning, statistical modeling, single-cell RNA-seq, computational chemistry, proteomics, metabolomics, and more. Engineering and infrastructure: Production-grade pipelines, tools, and systems, designed and built to suit your unique needs. Therapeutics-focused activities * Biomarker development * Target ID / Target Validation * Indication expansion / drug repurposing * Mechanism of action evaluation * Patient selection/stratification * Development of best analysis practices for high-throughput data * Target Identification and prioritization * Biomarker Discovery * Patient Selection and Stratification Other Bioinformatics activities * Pipeline design and development * Dashboard and web application builds * Custom analysis development and pipeline builds Genomics and data science technologies * Transcriptomics * Bulk RNAseq * Single-cell RNAseq * sc-ATAC-seq, TCR, cite-seq * Spatial transcriptomics * Multi-modal seq analysis DNA sequencing * WGS, WES * Long-read (pacbio, oxford nanopore) Proteomics Data Science * Machine learning * Statistical modeling * Visualization Structural biology and chemistry * Structural modeling * Docking

500 West Cummings Park Suite 3650 Woburn, MA, 01801 United StatesDigiM is the pioneer in microstructure science. We work closely with pharmaceutical scientists to advance drug development decisions through micro-scale image analysis and forensics. Through microstructure engineering our scientists work hand in hand to identify the best characterization solutions using X-ray micro-CT, X-ray microscopy, and FIB-SEM imaging techniques. Our AI based analysis tools has aided leading pharmaceutical innovators in assessing release performance, drug product quality, formulation decisions, and process optimization.

82 Highland Ave Unit 2 Somerville, MA, 02143 United StatesDropXcell enables biotechs to screen millions of antibodies per day with high throughput droplet-based screens, using capital equipment they already have. We offer a double emulsion platform, training on droplet microfluidics and FACS, as well as hourly or monthly consulting in or out of the lab.

800 District Avenue Suite 600 Burlington, MA, 01803 United StatesDRG is the premier provider of healthcare analytics, data and insight products and services to the worlds leading pharmas, biotech and medical technology companies.

PO Box 1921 Brookline, MA, 02446 United StatesScientific Visualization services. We innovate at the intersection of science, technology, art and learning to create accurate and effective visual context for understanding science. Our team members combine graduate-level training in the life sciences with industry-leading skills in animation, experience design and software development. Our projects include digital textbooks, multimedia for museums, marketing/communication for life sciences companies, science curricula and innovative visualization software tools and training.

210 Broadway Suite 201 Cambridge, MA, 02139 United StatesDesktop Genetics is a UK biotechnology company that imagines and creates intuitive software solutions and high performance assays for genome editing experiments.

34 Robbins Road Arlington, MA, 02476 United StatesDrug Delivery Solutions LLC provides expertise in drug delivery and formulation challenges for small-molecule drugs as well as biomolecules such as RNAs and peptides to early stage and established companies with focus on oncology and inflammation. The services include chemistry, for example syntheses of prodrugs and drug-polymer conjugates as well as solubility enhancement for poorly water soluble APIs. Formulation development includes nanocarriers such as liposomes/polymersomes, micelles, polymeric nanoparticles, LNPs, dendrimers, and emulsions. Drug Delivery Solutions has extensive experience in project management (program development, tasks, timelines, deliverables, budget), external technology evaluation, and IP management (disclosures, patent writing, and responses to office actions).

555 Technology Square Cambridge, MA, 02139 United StatesFrom whiteboard concept to fielded systems, Draper engineers design, develop and deploy advanced technology solutions for the world’s most difficult and important problems. More than a thousand engineers and scientists — experts in fields ranging from GN&C to microfabrication — bring a multidisciplinary advantage to system design. The breadth and depth of our expertise enable us to take on almost any challenge. By building and field-testing working prototypes we accelerate design iterations. We can complete small production runs, license our intellectual property and transition technology for large-volume production. We provide full life-cycle support, including technology refresh. We provide engineering services directly to government, commercial companies, and academia; work on teams as prime contractor or subcontractor, and participate as a collaborator in consortia. As a not-for-profit, we provide unbiased assessments of technology or systems designed or recommended by other organizations — whether custom-designed or commercial-off-the-shelf.

555 Technology Square Cambridge, MA , 02139 United StatesFrom whiteboard concept to fielded systems, Draper engineers design, develop and deploy advanced technology solutions for the world’s most difficult and important problems. More than a thousand engineers and scientists — experts in fields ranging from GN&C to microfabrication — bring a multidisciplinary advantage to system design. The breadth and depth of our expertise enable us to take on almost any challenge. By building and field-testing working prototypes we accelerate design iterations. We can complete small production runs, license our intellectual property and transition technology for large-volume production. We provide full life-cycle support, including technology refresh. We provide engineering services directly to government, commercial companies, and academia; work on teams as prime contractor or subcontractor, and participate as a collaborator in consortia. As a not-for-profit, we provide unbiased assessments of technology or systems designed or recommended by other organizations — whether custom-designed or commercial-off-the-shelf.

Dana-Farber Cancer Institute 450 Brookline Ave Mayer Building, Room 584 Boston, MA 02215We offer state-of-the-art, fully equipped flow cytometry instrumentation in two locations on the DFCI campus.

450 Brookline Avenue Boston, MA, 02215 United StatesWe offer state-of-the-art, fully equipped flow cytometry instrumentation in two locations on the DFCI campus.

197M Boston Post Rd W #243 Marlborough, MA, 01752 United StatesProteins comprise an extremely diverse class of biological macromolecules. They are often unstable when not in their native environments, which can vary considerably. If specific buffer conditions are not maintained proteins may lose activity, aggregate or fall into proteolysis. For this reason it is essential to nominate specific factors that increase the physical and chemical stability of each target protein. For these reasons we provide 7 different testing kits for protein optimization, protein storage, protein quality control , crystallization, fragment screening At Delta Tm Technologies we have developed a series of solution based kits that can be used to define the optimal protein buffer parameters using the Thermal Stability Assay (TSA).

222 Third Street, Suite 3211 Cambridge, MA 02142 USADyad Systems provides project rescue, trial auditing, and regulatory readiness.

160 New Boston Street Woburn, MA 01801 USADiagenics provides in vitro diagnostics and marketing for their cardiology, neurology, and gynecology products and research.

360 Longwood Avenue 43 Martingale Way - Longwood Center, 9th Floor Boston, MA, 02215 United StatesDana-Farber Cancer Institute maintains a variety of resources to support the research and educational activities of Dana-Farber faculty. These core facilities, shared resources, and integrative research centers offer research services to the Boston research community, including academic institutions and industry.

2 Winthrop Terrace United States Wayland, MASSACHUSETTS, 01778 United StatesDZZOM transforms OMICS into intelligence with NETWORK MEDICINE solutions, and makes targeted drug/biomarker R&D cost and time efficient. ZZOM is a biopharma focused network-sciences company. The Company has been incorporated with the mission to further develop and introduces its disruptive Network Medicine platform services throughout the entire life-cycle of drug/biomarker development and production. Our proprietary solutions have been developed based on the scientific concepts and results validated by our academic research partners. Network Medicine Network Medicine is the rapidly developing field, which applies systems/computational biology and network science methods to drug/biomarker development and production. Networks can be used to visualize and analyze a broad range of biological processes, with nodes in the network representing a biological entity (e.g., gene, protein, enzyme, or disease) and edges representing the relationships between entities (e.g., physical interactions, transcriptional activation, correlations in gene expression levels). This holistic approach is used to relate the complete set of macromolecular interactions between the biological entities and their products to diseases.

MA United StatesDZZOM transforms OMICS into intelligence with NETWORK MEDICINE solutions, and makes targeted drug/biomarker R&D cost and time efficient. ZZOM is a biopharma focused network-sciences company. The Company has been incorporated with the mission to further develop and introduces its disruptive Network Medicine platform services throughout the entire life-cycle of drug/biomarker development and production. Our proprietary solutions have been developed based on the scientific concepts and results validated by our academic research partners. Network Medicine Network Medicine is the rapidly developing field, which applies systems/computational biology and network science methods to drug/biomarker development and production. Networks can be used to visualize and analyze a broad range of biological processes, with nodes in the network representing a biological entity (e.g., gene, protein, enzyme, or disease) and edges representing the relationships between entities (e.g., physical interactions, transcriptional activation, correlations in gene expression levels). This holistic approach is used to relate the complete set of macromolecular interactions between the biological entities and their products to diseases.

55 Court Street Suite 330 Boston, MA, 02203 United StatesdoDOC offers easy-to-use features, designed to simplify how your team writes and reviews documentation.

55 Court Street, Suite 330 United States Boston, MA, 02108 United StatesdoDOC offers easy-to-use features, designed to simplify how your team writes and reviews documentation.

888 Worcester Street, Suite 90 Wellesley MA 02482Dragonfly Sciences focuses on the development of biosimilar molecules for monoclonal antibody and soluble receptor drugs.

450 Brookline Avenue Boston, MA, 02215 United States

Jimmy Fund Building, Rm 621, 35 Binney St, Boston, MA

Jimmy Fund Building, Rm 623, 35 Binney St, Boston, MA

450 Brookline Avenue Boston, MA, 02215 United States

Boston, MA United States

450 Brookline Avenue Boston, MA, 02215 United StatesOur goal in establishing a Center for Cancer Computational Biology (CCCB) is to begin to build the infrastructure necessary to address these needs and to establish the research capacity to address the next generation of questions arising from the application of new technologies across the research enterprise in order to keep Dana-Farber at the leading edge of cancer research.

480 Arsenal Street Watertown, MA, 02472 United StatesDicerna Pharmaceuticals is an emerging pharmaceutical company developing RNA interference (RNAi)-based therapeutics against genetically-defined targets in multiple disease areas, including cancer.

Health Communication Core Dana-Farber Cancer Institute 450 Brookline Ave, LW 601 Boston, MA 02215

375 Longwood Avenue Boston, MA, 02215 United States

One International Place, Suite 1400, Boston, MA 02110, USADiamond Pharma Services is a group of companies offering consulting services to support regulatory affairs and product development in the EU and US. Diamond BioPharm Ltd provides consultancy services in European regulatory affairs and product development to the biotech and pharmaceutical industries. The company was founded in 2005 under the leadership of Dr. Maureen Graham (ex. Amgen, MSD, Glaxo & IVAX). The team Dr Graham has established includes those with a broad and varied industry experience and former regulators, offering both breadth and depth of expertise, from which our clients can benefit. Our many years of industry experience and expertise is across a broad range of therapeutic areas and product types (biotechnology including monoclonal antibodies, gene-therapy and new chemical entities - both innovative and generics). The entire team has significant experience and knowledge of European regulatory procedures (national, mutual recognition, decentralised and centralised) and an in-depth awareness of current legislation and industry trends. Diamond BioPharm consultants have extensive experience of assisting clients with regulatory support from early stages of product development through to achievement of marketing authorisations, orphan designations, scientific advice and have also assisted with the maintenance of marketing authorisations through variations, and monitoring and updating of prescribing information. Diamond BioPharm Ltd was awarded TOPRA Innovation Award 2013 for supporting the first gene therapy product approval in Europe. Diamond Pharma Services, Inc. provides consultancy services in US regulatory affairs and product development to the biotech and pharmaceutical industries. The company was founded in 2015 as a subsidiary of Diamond BioPharm Ltd. Diamond Pharma Services, Inc. consultants have extensive experience of assisting clients with regulatory support from early stages of product development and IND initiation through to achievement of marketing authorisations, orphan designations and successful FDA meetings.

450 Brookline Avenue, LW601 Boston, MA 02215

375 Longwood Avenue Boston, MA, 02215 United States

41 Airport Road P.O. Box 39 Westfield, MA 01086-0039

Boston, MA, USADr. Xiang Gao offers consulting services.

1118 Folk Drive Oakwoodland, OR, 02343 United StatesDragon Pharmacology provides research models for various diseases. Dragon Pharmacology is a trusted *TEST* vendor for pharmacological animal models and the Best Service Ever . **Test Company for Demos**

6 Henshaw Street Woburn, MA, 01801 United StatesAsk us about our cell and gene therapy products, including both research and clinical use Discovery Leukopaks. Discovery Life Sciences are the Biospecimen & Biomarker Specialists™. We have the world’s largest biospecimen inventory and procurement network with preeminent multi-omic service laboratories to accelerate precision medicine programs in oncology, immuno-oncology, immunology, inflammation, infectious diseases, and beyond. We are pleased to announce ReachBio is now a part of Discovery Life Sciences. Our biobanks include more than 10 million biospecimens and we have hundreds of clinical sites (Discovery Partners®) that allow researchers to build bespoke study cohorts and seamlessly interrogate them using our CLIA certified, GLP-compliant service laboratories, including our world-renowned Genomic Sequencing and bioinformatics laboratory, HudsonAlpha Discovery, our expert IHC services laboratory that developed the pembrolizumab PD-L1 IHC companion diagnostic prototype, our Proteomic Services labs that offer Olink, Luminex, Seer Proteograph and Mass Spec protein profiling, and our Cell Biology laboratory providing extensive Flow cytometry and single cell RNASeq services with GMP-compliant leukapheresis products for cell therapy development and manufacturing. We are committed to quality and integrity with ISO 13485, GMP- and GCLP-compliant and CLIA-certified labs, stringent IRB and Ethics Committee compliance, and all required approvals and certifications. Navigating US and international personal data protection, drug development and diagnostic development regulations is one of our core competencies.

185 ALEWIFE BROOK PARKWAY SUITE 210 CAMBRIDGE, Massachusetts, 02138 United StatesDECIPHEX ACCELERATES CERTAINTY IN PATHOLOGY SERVICE DELIVERY BY NETWORKING PATHOLOGISTS AND USING ARTIFICIAL INTELLIGENCE TO DRIVE EFFICIENT, HIGH-QUALITY REPORTING. Patholytix is the industry-leading digital pathology workflow & integrated AI platform for Research Pathology. Patholytix is trusted by the leading CROs and pharmaceutical companies for handling high volume drug safety pathology studies, providing a complete GLP-compliant workflow with integrated AI screening capabilities. Diagnexia is an online clinical pathology department that provides on-demand access to remote subspecialty pathologists for primary diagnostics and secondary consult services, supporting the acceleration of diagnostic turnaround times and delivery of the highest quality of patient care.

Canton, MA United StatesEquipnet provides appraisal services, corporate solutions, procurement,and asset sales.

Watertown, MA, USAEnVivo Pharmaceuticals provides drug discovery and development for nervous system disorders.

500 Boylston Street Suite 1600 Boston, MA 02116 USAEnlight Bioscience focuses on pioneering breakthrough innovations for drug discovery and development.

Boston, MA United StatesEnlight Bioscience focuses on pioneering breakthrough innovations for drug discovery and development.

2 Shaker Road, Unit B101 Shirley, MA 01464 USAExalpha Biologicals supplies proliferation/apoptosis assays, enzymes, proteins, ELISA kits, and membrane preparation services.

100 Beaver Street Waltham MA 02453Epitome Biosystems provides biological pathway analysis, drug target validation, cell/tissue profiling, biomarker discovery, and dose response profiling.

Waltham, MA United StatesEpitome Biosystems provides biological pathway analysis, drug target validation, cell/tissue profiling, biomarker discovery, and dose response profiling.

96 South Street, Hopkinton, MA 01748With over 15 years of experience in genetic and epigenetic clinical research, EpigenDx offers high quality products and laboratory services focused on DNA methylation analysis, gene expression profiling, and mutation analysis. Our scientific teams carefully evaluate each project and establish analysis procedures using best fit technologies, including NGS, Pyrosequencing, RT-PCR, digital PCR, and GeneChip Microarray. Our popular services include Line-1 global methylation tests and Foxp3-TSDR analysis for epigenetic immunotherapy. Our GLP compliant and CLIA certified services make us the perfect partner during pre-clinical research and diagnostic test development.

96 South Street United States Hopkinton, MA, 01748 United StatesWith over 15 years of experience in genetic and epigenetic clinical research, EpigenDx offers high quality products and laboratory services focused on DNA methylation analysis, gene expression profiling, and mutation analysis. Our scientific teams carefully evaluate each project and establish analysis procedures using best fit technologies, including NGS, Pyrosequencing, RT-PCR, digital PCR, and GeneChip Microarray. Our popular services include Line-1 global methylation tests and Foxp3-TSDR analysis for epigenetic immunotherapy. Our GLP compliant and CLIA certified services make us the perfect partner during pre-clinical research and diagnostic test development.

245 First Street, 18th Floor Cambridge, MA 02142 USAeMolecules is an eCommerce company that supplies samples to customers all over the world with a strong background in cheminformatics.

Chelmsford, MA, USAElm Hill Labs provides guinea pigs for research.

Chelmsford, MA United StatesElm Hill Labs provides guinea pigs for research.

263 Huntington Ave Suite 346 Boston, MA, 02115 United StatesSince its establishment in 2008, Ekam Imaging has emerged as the undisputed leader in preclinical Magnetic Resonance Imaging. As the only Contract Research Organization (CRO) that conducts MRI scans on conscious and awake subjects, our approach guarantees results that are highly predictive of clinical outcomes. By leveraging the best possible method for ensuring accurate and relevant data, Ekam Imaging is at the forefront of preclinical research, providing our clients with unparalleled insights and expertise. Located in Boston, Ekam Imaging is a hybrid CRO that partners with MR Imaging centers in top universities in the area, this strategic partnership allows us to utilize cutting-edge instrumentation and a highly skilled workforce, enabling us to consistently deliver reliable and high-quality results in a timely manner. At Ekam, our team is led by top scientists in the field, ensuring that our services are conducted to the highest standards of scientific rigor. With our state-of-the-art facilities, experienced staff, and commitment to excellence, Ekam Imaging is the ideal partner for preclinical Magnetic Resonance Imaging research.

Exiqon Inc, 12 Gill Street, Suite 1650, Woburn, MA 01801, USA.Exiqon operates in two business areas: Life Sciences and Diagnostics. Exiqon Life Sciences, a leading provider of flexible solutions for RNA analysis. Exiqon’s research products are used by academia, biotech and pharmaceutical companies around the world to make groundbreaking discoveries about the correlation between gene activity and the development of cancer and other diseases. Exiqon Diagnostics collaborates with pharmaceutical and diagnostic companies to develop novel molecular diagnostic tests for early detection of diseases which can help physicians make treatment decisions based on the tools developed by Exiqon Life Sciences. Exiqon is listed on the NASDAQ Copenhagen.

Woburn, MA United StatesExiqon operates in two business areas: Life Sciences and Diagnostics. Exiqon Life Sciences, a leading provider of flexible solutions for RNA analysis. Exiqon’s research products are used by academia, biotech and pharmaceutical companies around the world to make groundbreaking discoveries about the correlation between gene activity and the development of cancer and other diseases. Exiqon Diagnostics collaborates with pharmaceutical and diagnostic companies to develop novel molecular diagnostic tests for early detection of diseases which can help physicians make treatment decisions based on the tools developed by Exiqon Life Sciences. Exiqon is listed on the NASDAQ Copenhagen.

14 Dundonald Rd United States Belmont, MA, 02478 United StatesScientific Consultant - Experienced Bioinformatician synthesizes knowledge from experiments, big data mining, computation and experience Quickly identify needs and their solutions Deliver reliable, high quality bioinformatics from basic data handling to most sophisticated mining & visualization. Implement efficient computational and experimental pipelines to get a job done Help wet-labs improve processes, quality and turnaround Provide preclinical and clinical statistics support Manage projects, studies, collaborations and resources Deliver toward goals and ensure knowledge transfer Respond quickly and allow maximal flexibility Understand biopharma discovery & development Combine in-depth technology expertise with therapeutic area knowledge

56 Roland Street, Suite 203 Boston, MA 02129Eton Bioscience Inc. is a biotech company specializing in DNA sequencing and oligo synthesis services nationwide. Founded in 2003 in San Diego, California, we have been providing scientists of both academia and industry with a variety of services and products to assist them in research. At Eton we strive to provide only the best through our high quality and reliable services, customer care and competitive pricing. We understand that by developing and utilizing the latest innovative techniques, sustainable practices, and efficiency, we are on the way to becoming the number one DNA sequencing company in the nation. Taking pride in what we do, we deliver science, not words.

480 Arsenal Street Watertown, MA, 02472 United StatesEmber Therapeutics is a product-focused company harnessing breakthroughs in brown fat biology to revolutionize the treatment of metabolic disease.

1 Broadway Cambridge Cambridge Innovation Center Cambridge, MA, 02142 United StatesEra7 Bioinformatics is a company that provides services of NGS illumina and PacBio sequencing and bioinformatics analysis focused on bacterial genomics, metagenomics and trancriptomics. We also provide Inmmunogenomics services sequencing and analyzing TCR and BCR repertoires.

430 Bedford Street Suite 300 Lexington Office Park Lexington, MA 02420Evidera was formed in 2013 when Symphony Technology Group (STG), a private equity firm focused on technology and services, acquired the health economics (HE), outcomes research (OR), market access, epidemiology and data analytics practices of United BioSource Corporation (UBC), a wholly owned subsidiary of Express Scripts Holding Company. Evidera has over 30 year of leadership and experience and its legacy brands include MEDTAP, Caro Research, Abt Bio-Pharmaceutical Solutions, MetaWorks, Total Healthcare Group and Archimedes. Evidera’s 300 researchers and consultants have expertise working in all developed and many developing countries. U.S. headquarters in Bethesda, MD (Washington, D.C.) European headquarters in London Primary offices in Boston, Budapest, Harrisburg, Montreal, San Francisco and Seattle

Andover, MA, USAEisai Research Institute (ERI) provides drug research, drug development, clinical trials, and drug discovery.

Andover, MA United StatesEisai Research Institute (ERI) provides drug research, drug development, clinical trials, and drug discovery.

101 Billerica Avenue Building 4, Suite 103 North Billerica, MA 01862 USAEurofins EAG Materials Science, LLC has a long history, dating back to the birth of the company in 1978 in California, as Charles Evans & Associates. Over the years we have expanded from a single location offering SIMS only to having over 200 employees offering over 30 different services via 14 locations in 8 different countries. The original focus of the company was supporting semiconductor manufacturing but now we also work with multiple further industries beyond semiconductors, including: solar/PV, lighting, photonics, energy storage, aerospace & defense, medical devices, raw materials, glass, polymers and plastics and consumer products. EAG's analytical expertise is what enables us to help our clients to meet their goals. Our on-demand analytical testing services can help streamline R&D, solve urgent problems during manufacturing and help resolve materials related issues in the global supply chain, both within and between organizations.

278 Mile Hill Road Boylston, MA 01505 USAEastwoods Consulting advises companies on the commercialization of life science technologies.

200 Springs Road Bedford, MA 01730Bedford VAMC has a full continuum of mental health programming, including a number of nationally known exemplars in the areas of Vocational Services, Peer Services, Homeless Services and outpatient Mental Health services. Programming is organized around a "recovery oriented" treatment philosophy, and the Mental Health Service Line is a national leader in psychosocial rehabilitation, research and education.

200 Springs Road Bedford, MA, 01730 United StatesBedford VAMC has a full continuum of mental health programming, including a number of nationally known exemplars in the areas of Vocational Services, Peer Services, Homeless Services and outpatient Mental Health services. Programming is organized around a "recovery oriented" treatment philosophy, and the Mental Health Service Line is a national leader in psychosocial rehabilitation, research and education.

40 Warren Street, 3rd Floor Boston, MA, 02129, USAEstern Medical provides clinical research services, Phase I-IV support, recruitment, and medical writing.

Boston, MA United StatesEstern Medical provides clinical research services, Phase I-IV support, recruitment, and medical writing.

140 Hale Street Haverhill, MA, 01830 United StatesEmbryotech Laboratories is an ISO-17025 accredited test laboratory providing services to the assisted reproductive technologies industry and laboratories, providing quality control assays including: Mouse Embryo Assay that is used for toxicity and functionality testing of raw materials, media, labware, disposables and any device which may come into contact with gametes or embryos. Also offering endotoxin testing via Limulus Amebocyte Lysate Assay: Kinetic Turbidimetric quantitative and Gel-Clot qualitative testing. Embryotech Laboratories is also a provider of several human sperm assays. In addition, it is the leader in supplying all stages of fresh and cryopreserved mouse embryos as well as hamster ova.

1 Technology Place Rockland, MA, 02370 United StatesEMD Serono has more than 30 trials in our global clinical pipeline, focused on developing innovative therapies for cancer and neurodegenerative diseases such as multiple sclerosis and Parkinson's disease.

500 Arsenal Street Watertown, MA 02472Enanta Pharmaceuticals is a research and development-focused biotechnology company that uses its robust chemistry-driven approach and drug discovery capabilities to create small molecule drugs for viral infections and liver diseases. Enanta’s research and development is currently focused on four disease targets: Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), Non-alcoholic Steatohepatitis (NASH) and Respiratory Syncytial Virus (RSV). Enanta has developed novel protease inhibitors and NS5A inhibitors that are members of the direct-acting-antiviral (DAA) inhibitor classes designed for use against the hepatitis C virus (HCV). Enanta’s protease inhibitors, developed through its collaboration with AbbVie, include paritaprevir, which is contained in AbbVie’s marketed DAA regimens for HCV, and ABT-493, Enanta’s second protease inhibitor which AbbVie is developing in phase 3 studies in combination with ABT-530, AbbVie’s NS5A inhibitor. Enanta has also discovered a cyclophilin inhibitor, EDP-494, a novel host-targeting mechanism for HCV, which is now in a phase 1 clinical development.

266 Second Ave Suite 200 Waltham, MA, 02451 United StatesExosome Diagnostics, Inc. is pioneering the field of biofluid-based medical diagnostics in areas intended to augment surgical biopsy techniques.

275 Grove Street Suite 2-101 Newton, MA 02466Empiriko is a biotechnology company that designs game-changing solutions for drug discovery, development and patient treatment. Empiriko’s unique biomimetic platform – Biomimiks™ – closely mimics the oxidative function of the liver by incorporating chemical catalysts, biological processes and computational modeling. The power of these “chemosynthetic livers” is that they quickly and precisely predict the liver’s metabolic reactions to drugs – accelerating drug development, uncovering safety issues, decreasing time and cost, and reducing animal testing. With Biomimiks™: Research scientists can reduce the attrition of new chemical entities (NCEs) by conducting early metabolism studies, generating quantitative measures of toxicity and reducing the necessity of animal experimentation. Clinicians can analyze metabolic patterns to assess drug-to-drug interactions and the safety and efficacy associated with adding a new drug to a patient’s drug regimen. Pharmaceutical companies can rapidly propel advances in drug discovery and clinical development while introducing new and more efficacious compounds, cutting costs and reducing compound attrition. Empiriko’s Biomimiks™ platform is designed to include components that can be shared across the entire drug life cycle, ensuring that new applications can be easily developed and deployed. This powerful technology provides the speed, stability and scalability needed to support ongoing pre-clinical iteration and to design safer and more effective drugs cost-effectively.

55 Cambridge Parkway Cambridge, MA, 02142 United StatesEdimer will deliver a significant and durable improvement in the health and quality of life to future generations affected by the rare genetic disorder, X-linked Hypohidrotic Ectodermal Dysplasia (XLHED)

100 Beaver Street Waltham, MA 02453Eyegate Pharmaceuticals focuses on the formulation and development of ocular drug delivery.

400 The Fenway Boston, MA 02115Emmanuel College (EC) is a coeducational Roman Catholic liberal arts college located in Boston, Massachusetts. The college was founded by the Sisters of Notre Dame de Namur as the first women's Catholic college in New England. In 2001, the College officially became a coeducational institution.

325 Vassar Street Suite 2B Cambridge, MA 02139 USAEpizyme provides epigenetics, cell differentiation, histone modifying enzymes, and protein expression.

22 Alpha Road Chelmsford MA 01824Esa Biosciences offers metabolomics and clinical lab services, stability and degradation studies, redox profiling and electrochemically assisted ionization LC/MS services.

One Beacon Street, 15th Floor Boston, MA, 02108 United StatesWe collaborate with the world’s leading pharma, biotech and academic organisations to lower the risks and time frames in disease research and preclinical drug discovery Euretos provides a unique combination of predictive computational disease models and direct access to our AI-integrated knowledge base of biomolecular databases, literature and patents to evaluate predictions and findings. This empowers scientists to draw their own, evidence based, conclusions and develop data-driven insights into human disease biology. Our ready-to-use applications and capabilities enable taking a data-driven approach to: Target Discovery - Novel target predictions to improve preclinical pipeline performance in all therapeutic areas Indication Selection - Novel disease association predictions to expand indications of existing drugs Target Evaluation - Accelerate assessment of target candidates from in-house discovery and in-licensing

767C Concord Ave Cambridge, Massachusetts, 02138 United StatesEutropics is a biomarker discovery and clinical diagnostics, CLIA laboratory in Cambridge, MA. We provide a variety of ELISA and flow cytometry-based CLIA testing, including flow cytometry based functional and static assays that assess cancer patient biopsied cells for drug sensitivities We also provide ELISA based testing for serum markers including Human Anti-Mouse Antibodies (HAMA) including HAMAs against radionuclide antibody conjugates (RACs) for instance, Alpha-particle Therapies (TAT). Eutropics holds a radioactivity license to process biopsies from patients being treated with such therapies. Our core capability lies in providing novel clinical diagnostic test platform that recognizes apoptotic potential of biopsied cancer cells, for instance Bcl-2 protein family dependencies. The information indicates the likelihood of patient response and can be used in selecting patients for clinical trials. Our approach to assessing "BCL2 dependencies" using novel "PRIMAB" antibodies that measure the function of the Bcl-2 protein family. . The PRIMABS selectively bind to specific Bcl-2 family protein complexes. Readouts are detected on flow cytometry or IHC. . The complexes are known to correlate to cancer cell responsiveness to a wide range of apoptosis-inducing therapies, including BH3 mimetics. CLIA technical and clinical validation of PRIMAB based or other biomarker tests are performed at Eutropics. Patient sample processing of fresh or viably frozen patient samples on flow cytometry and ELISA platforms is available. IHC services are also available.

767C Concord Ave Cambridge, Massachusetts, 02138 United StatesEutropics is a biomarker discovery and clinical diagnostics, CLIA laboratory in Cambridge, MA. We provide a variety of ELISA and flow cytometry-based CLIA testing, including flow cytometry based functional and static assays that assess cancer patient biopsied cells for drug sensitivities We also provide ELISA based testing for serum markers including Human Anti-Mouse Antibodies (HAMA) including HAMAs against radionuclide antibody conjugates (RACs) for instance, Alpha-particle Therapies (TAT). Eutropics holds a radioactivity license to process biopsies from patients being treated with such therapies. Our core capability lies in providing novel clinical diagnostic test platform that recognizes apoptotic potential of biopsied cancer cells, for instance Bcl-2 protein family dependencies. The information indicates the likelihood of patient response and can be used in selecting patients for clinical trials. Our approach to assessing "BCL2 dependencies" using novel "PRIMAB" antibodies that measure the function of the Bcl-2 protein family. . The PRIMABS selectively bind to specific Bcl-2 family protein complexes. Readouts are detected on flow cytometry or IHC. . The complexes are known to correlate to cancer cell responsiveness to a wide range of apoptosis-inducing therapies, including BH3 mimetics. CLIA technical and clinical validation of PRIMAB based or other biomarker tests are performed at Eutropics. Patient sample processing of fresh or viably frozen patient samples on flow cytometry and ELISA platforms is available. IHC services are also available.

57 Smith Pl Cambridge, MA, 02138 United StatesWe provide custom protein production, biochemical assay development, and DEL optimization

81 Hartwell Ave Suite 240 Lexington, MA, 02421 United States

27 Strathmore Rd Natick, Massachusetts, 01760 United StatesEverCell Bio is your premium stem cell partner. You can expect customized solutions leveraging innovative technology, our comprehensive service platform, and combined 30+ years of stem cell experience. EverCell Bio offers three categories of services to meet all of your stem cell needs. 1. Human cell services: reprogramming, gene modification, differentiation, human cell culture, cell banking, and custom characterization 2. Product services: product testing, comparative evaluation, and quality control and assurance 3. Support services: technical support, scientific consultations, on-site support, and stem cell training All services are delivered with the highest quality and consistency technically possible.

210 Broadway #201 Cambridge, MA 02139 USAEmulate, Inc. is a private company that creates living products for understanding how diseases, medicines, chemicals, and foods affect human health. By setting a new standard for recreating true-to-life human biology, Emulate is advancing product innovation, design, and safety across a range of applications in drug development, agriculture, cosmetics, chemical-based consumer products, and personalized health. *Organs- on-a-chip* Brain colon-intenstine Duodenum Kidney Liver Lung *Landmark Publication Validates Organ-on-a-Chip Technology for Predictive Toxicology* In a landmark study published in Communications Medicine, part of Nature Portfolio, researchers measured how effective the Emulate human Liver-Chip is at predicting human response to toxic drugs compared to animal and hepatic spheroid models. The results were staggering: the Emulate human Liver-Chip was able to correctly identify 87% of drugs that caused drug-induced liver injury to patients despite passing through animal testing.

618 Cambridge Street Cambridge, MA, 02141 United StatesFractal Therapeutics specializes in leveraging focused model-based analyses to quickly and efficiently advance drug discovery and development projects. We do this using parsimonious fit-for-purpose models based on preclinical and early-clinical data, that provide clear direction for experimental design and strategic decision-making, within very short timelines. We are drug development scientists, skilled at using model-based approaches as a means to an end. Our team has spent many years working together in Big Pharma, learning what works and what doesn’t in model-based drug development. Our scientists can work collaboratively with you to design optimal experiments that are focused narrowly on the critical path to the first-in-human trials, and to help you make the right design choices to advance your molecule quickly and cost-efficiently to the right decisions.

20 North Avenue Burlington, MA 01803For over two decades, the development of complex software-intensive and electromechanical products and systems has been our focus. It's also our passion. We thrive on shouldering and solving the business and technical challenges that keep our clients up at night. There's no reason for all of us to be up all night. Working with clients in some of the most highly regulated and rapidly evolving INDUSTRIES, Foliage offers a comprehensive suite of consulting and development SERVICES that will launch your concepts from the drawing board to the marketplace. Find out why Foliage has become a trusted partner to so many leading brands and successful start-ups. We can give your company a distinct advantage in today's fiercely competitive marketplace.

790 Memorial Drive Cambridge, MA 02139 USAForma Therapeutics offers high throughput screening and cell based screening services to support target identification and assay development.

200 Dexter Ave Suite 140 MA - Massachusetts, MA, 02472 United StatesLife Sciences tools company. Two products: large scale single cell expression profiling kits and very low sample input targeted DNA preparation kits (easily customized for cancer monitor and tissue bank mining).

15 Palmer St. Suite A WATERTOWN, MA, 02472 United StatesLife Sciences tools company. Two products: large scale single cell expression profiling kits and very low sample input targeted DNA preparation kits (easily customized for cancer monitor and tissue bank mining).

201 Dexter Avenue Suite A Watertown, MA, 02472 United StatesLife Sciences tools company. Two products: large scale single cell expression profiling kits and very low sample input targeted DNA preparation kits (easily customized for cancer monitor and tissue bank mining).

Waltham, MA, USAFinnBrit Consulting provides consulting services for due diligence, formulation, drug development, and quality assurance.

60 Prescott St Worcester, MA, 01605 United StatesFornax Biotech is a US biotechnology company focused on the customized solutions on next-generation sequencing (NGS), bioinformatics, and RNA-related services, as well as assay development to facilitate drug discovery and academic research.

60 Prescott St Worcester, MA, 01605 United StatesFornax Biotech is a US biotechnology company focused on the customized solutions on next-generation sequencing (NGS), bioinformatics, and RNA-related services, as well as assay development to facilitate drug discovery and academic research.

150 Second Street Cambridge, MA, 02141 United StatesFoundation Medicine is leading a transformation in cancer care, where each patient’s treatment is informed by a deep understanding of the molecular changes that contribute to their disease. We are currently collaborating with more than 20 biotech and pharmaceutical companies, as well as numerous academic medical centers, to help accelerate the development of new targeted therapies. Utilizing our molecular information platform, we enable better selection of drug candidates, a better understanding of mechanisms of sensitivity or resistance, more efficient clinical trial design and faster patient recruitment into clinical trials. Ultimately, we believe these partnerships will accelerate the delivery of safe, effective targeted therapies available for patients with cancer.

38 Wareham Street Boston, MA, 02118 United StatesFlaskworks offers dendritic cell and macrophage generation from PBMCs, bone marrow, and other sources such as CD34+ cells. We can source human as well as animal blood. Culture protocols can be customized based on client needs and we can ship frozen cells to our clients. We can also perform cell separation in a donor/animal specific manner, e.g. extract monocytes from PBMCs to differentiate into dendritic cells or macrophages and then ship remaining PBMCs (or purified subpopulations) and dendritic cells/macrophages back to client in cryopreserved form. We are located in Boston and offer fast delivery to Boston-area clients. We also serve clients all over the US and internationally.

10 Forge Park Franklin, MA 02038 USAFisher Bioservices offers biorepository and biobanking services, clinical trial sample management, specimen processing, DNA/RNA extraction, and PCR/QPCR services including WGA PCR, cell therapy storage and logistics, and biologic API transport, storage and handling.

1254 Main St. Waltham, MA 02451 USAFormulatrix provides protein crystallization automation solutions and develop liquid handlers.

30 Sudbury Road, Suite 1A North Acton, MA 01720 USAFitzgerald Industries International provides over 20,000 highly purified Monoclonal and Polyclonal Antibodies, purified Antigens, ELISA Kits and Specialty Research Products.

Canton, MA, 02021 United StatesFirst Immuno-Consulting LLC, is dedicated to providing market intelligence and strategic planning consulting services. Our services will help prepare companies for opportunities to improve the organization's position within life science markets and achieve financial growth. We look beyond the common practice of incorporating general vendor exhibits as part of business development strategies. Targeted visibility and market research are key factors. Our work is driven by a clear understanding of the value of a targeted business development solution that is client-centered.

Bay Drive Canton, MA, 02021 United StatesFirst Immuno-Consulting LLC, is dedicated to providing market intelligence and strategic planning consulting services. Our services will help prepare companies for opportunities to improve the organization's position within life science markets and achieve financial growth. We look beyond the common practice of incorporating general vendor exhibits as part of business development strategies. Targeted visibility and market research are key factors. Our work is driven by a clear understanding of the value of a targeted business development solution that is client-centered.

200 Boston Avenue Suite 1850 Medford MA 02155 USAFebit BioMed provides expression profiling, biochip design, gene sequence capture, and synthetic genes.

Boston, MA USAFermentöme has developed a patent-pending technology that will commercialize a novel micro-fermentation platform that enables the culture of the vast majority of previously uncultivable microbial strains from biological or environmental samples.

245 First Street Cambridge, MA 02142 USAForsyth Institute maintains specialty Core Services that provide specialized equipment and expertise for its investigators and, on a fee-for-service basis, to researchers from other institutions.

Cambridge, MA United StatesForsyth Institute maintains specialty Core Services that provide specialized equipment and expertise for its investigators and, on a fee-for-service basis, to researchers from other institutions.

One Kendall Square Building 1400W, 3rd Floor Cambridge, MA 02139 USAFirefly BioWorks, Inc. has developed a customizable microRNA detection platform for rapid profiling of diverse biological samples.

Cambridge, MA United StatesFirefly BioWorks, Inc. has developed a customizable microRNA detection platform for rapid profiling of diverse biological samples.

203 Crescent Street Waltham, MA, 02453 United StatesTo liberate patients, empower physicians, and lower health care costs by developing device-based solutions to chronic diseases.

200 Bulfinch Drive Andover, MA 01810Formatech offers preformulation, formulation development, lyophilization, cell culture, fermentation, peptide and antibody purification, stability testing, and manufacturing services.

Andover, MA United StatesFormatech offers preformulation, formulation development, lyophilization, cell culture, fermentation, peptide and antibody purification, stability testing, and manufacturing services.

536 Frank Smith Rd Longmeadow, Massachusetts, 01106 United StatesFortelinea develops tissue tracking and management software for research and pharmaceutical labs.

1440 Main Street, Suite 300 Waltham, MA, 02451 United StatesFortis partners with diagnostics and life sciences companies to design, validate, and manufacture solutions to solve your complex development problems. At Fortis, we understand the impact scientific discovery has on society and how it affects people and human health. Therefore, we think about the effect your work has on the world every single day. Great products are everywhere. Yet, somewhere between the rapid advancement of science and technology, our industry lost something important. We lost the ease of connecting and the simplicity of getting the answers you need, when you need them. We are committed to developing reagents of the highest quality standards so your work continues with maximum integrity. But this is just our first step. Our products are backed by strong and knowledgeable customer and technical support. So, whether you prefer a digital self-service experience or connecting with us live, we promise reliable, responsive services to collaboratively support your success. It is our promise to ensure that every click, every purchase, and every interaction with Fortis brings you one step closer to discovery and -together- brings us one step closer to a healthier world. Powered by our brands: Bethyl Laboratories, nanoComposix, Empirical Bioscience, Arista Biologicals, Abcore, iPOC

1440 Main Street Waltham, MA, 02451 United StatesFortis partners with diagnostics and life sciences companies to design, validate, and manufacture solutions to solve your complex development problems. At Fortis, we understand the impact scientific discovery has on society and how it affects people and human health. Therefore, we think about the effect your work has on the world every single day. Great products are everywhere. Yet, somewhere between the rapid advancement of science and technology, our industry lost something important. We lost the ease of connecting and the simplicity of getting the answers you need, when you need them. We are committed to developing reagents of the highest quality standards so your work continues with maximum integrity. But this is just our first step. Our products are backed by strong and knowledgeable customer and technical support. So, whether you prefer a digital self-service experience or connecting with us live, we promise reliable, responsive services to collaboratively support your success. It is our promise to ensure that every click, every purchase, and every interaction with Fortis brings you one step closer to discovery and -together- brings us one step closer to a healthier world. Powered by our brands: Bethyl Laboratories, nanoComposix, Empirical Bioscience, Arista Biologicals, Abcore, iPOC

1700 West Park Drive, Suite 260 Westborough, MA 01581 USAGenomeQuest provides large-scale genomic software applications.

Cambridge, MA United StatesGenstruct offers knowledge assembly models, biomarkers, and systems biology.

3400 Computer Drive Westborough, MA 01581Genzyme Genetics offers immunophenotyping, oncology testing, and reproductive testing services.

500 Kendall Street Cambridge, MA 02142Genzyme Genetics offers immunophenotyping, oncology testing, and reproductive testing services.

Cambridge, MA United StatesGenzyme Genetics offers immunophenotyping, oncology testing, and reproductive testing services.

738 Main Street, Suite 390 Waltham, MA 02451-0616 USAGraffinity offers fragment based drug discovery and lead development including technologies in chemical microarrays, fragment screening, SPR label free imaging of protein ligand interactions, and computational chemistry.

245 First Street Suite 100 Cambridge, MA, 02142 United StatesG&L utilizes decades of experience and a wealth of Subject Matter Expertise in Regulatory Affairs, Quality Assurance and Clinical Development to design and deliver solutions to the biggest challenges faced by global healthcare today. G&L’s reputation for designing and delivering highly effective solutions to the biggest challenges in global healthcare and our commitment to ensuring that our clients’ specific requirements are always met have seen the company experience phenomenal growth since our establishment in 2016. This has been accompanied by increased global client demand for the provision of additional services and solutions that utilize our Regulatory Affairs, Quality Assurance and Clinical Development knowledge and experience to give them a competitive edge. In response, our core services, while committed to Regulatory Affairs, Quality Assurance and Clinical Development, have expanded accordingly. From product development and submissions to company-wide change management, G&L Healthcare Advisors is proud to design, implement, and maintain high-quality, results-focused outcomes for everyone with whom we work.

90 Canal St Suite 120 Boston, Massachusetts, 02114 United StatesGenuity Science is on a mission to improve lives through genomics. We partner with drug discovery companies to accelerate their insight into the most difficult-to-treat diseases. Leveraging whole genome sequence and rich clinical data, we identify and validate novel drug targets and drug response biomarkers. Genuity Science is headquartered in Boston, Massachusetts, USA with offices in Dublin, Ireland, and Reykjavik, Iceland. Services include population-scale, disease-specific data sourcing, high-quality sequencing, robust statistical analysis, and software tools for analyzing large datasets and artificial intelligence (AI). The company operates advanced CAP-accredited genomics laboratories in Dublin, Ireland, and is deeply committed to data stewardship and data governance across its global offices. For more information, visit us at www.genuitysci.com.

2-F Gill Street Woburn , MA, 01801 United StatesGenuity Science is on a mission to improve lives through genomics. We partner with drug discovery companies to accelerate their insight into the most difficult-to-treat diseases. Leveraging whole genome sequence and rich clinical data, we identify and validate novel drug targets and drug response biomarkers. Genuity Science is headquartered in Boston, Massachusetts, USA with offices in Dublin, Ireland, and Reykjavik, Iceland. Services include population-scale, disease-specific data sourcing, high-quality sequencing, robust statistical analysis, and software tools for analyzing large datasets and artificial intelligence (AI). The company operates advanced CAP-accredited genomics laboratories in Dublin, Ireland, and is deeply committed to data stewardship and data governance across its global offices. For more information, visit us at www.genuitysci.com.

4 Technology Way Salem, Massachusetts, 01970 United StatesGenoskin is a biotech company with research facilities in Toulouse, France, and Boston (USA). The company specializes in first-in-human data generation for the biotech, pharma as well as cosmetic and consumer goods industry. Genoskin has developed the world’s first ex vivo platform to test the toxicity and efficacy of drug candidates, including biologics or small molecules, that are administered by intradermal or subcutaneous injections. Leveraged by artificial intelligence and machine learning, Genoskin's human skin platforms generate actionable human data ahead of clinical trials to significantly reduce the costs, duration and risks inherent in drug development To do so, we use patented technologies to bio-stabilize, in a functional survival state, discarded human skin tissue obtained from plastic procedures. Our living and immunocompetent ex vivo human skin models are closest to what can be seen during clinical trials and are a reliable alternative to animal testing.

258 Harvard Str #352 Brookline, MA, 02446 United StatesYour one stop solution for all your machine learning & bio-informatics needs. Relevant projects: Topic 1: “Clustering Single-cell data (10X) from differentiating cell lines for differentiation Biomarker’s identification” Analyzed both client single-cell (10X) data and public (Drop-seq) single-cell data for differentiating cell lines. Performed data QC, across platform integration, and post-clustering collection of differentially expressed genes, and expression maps. Specifications of the different biomarkers. Topic 2: “Assessing quality and biological relevance of DNA Methylation” Analyzed both Illumina EPIC DNA methylation array and Reduced representation bisulfite sequence (RRBS) data sets at methylation mapping, quality control assessment and analysis with differential methylation (DM) of many different genome regions. Topic 3: “Applied polypharmacology” Develop and test methods of applied system pharmacology to analysis of an invitro characterization of a complete “drug to target” specificity map for a set of unspecific inhibitors and an in vivo phenotypic assay of a subset of these drugs. Construction of cocktails of drugs specific to some kinases using the “drug to target” specificity map. Topic 4: “Comprehensive characterization of protein dynamics” Developing quantitative machine learning methods to compute the synthesis and degradations rates including the confidence intervals which allow to deeper explore the functional subgroups of proteins and their properties. Performing clustering of protein dynamic patterns and gene enrichment analysis corresponding to these clusters allow to identify the transition point from the morphogenesis to organogenesis. Topic 5: “Genome Analysis” Developing computational tools (with web interface) for the comprehensive redundancy analysis for proteomes using various state-of-the-art numerical algorithms for sequence homology detection and specification of putative functions assigned to genes in unstudied organisms. In addition, performed a Bayesian confidence interval assignment in quantitative proteomics. Topic 6: “Machine Learning in protein analysis” Developing of a suitable predictive model assessing the effect of amino acid changes on a protein and its behavior. Report of data characteristics affecting the binding properties of proteins. Implemented predictive approach towards the impact on binding properties. Developing and implementing computational tools that assist in automating and streamlining structural protein screening.

9 Appleton Street Unit.405 Boston, MA, 02116 United StatesGL Biochem is an internationally well-recognized peptide reagent, custom peptide, and antibody manufacturing company with a 450,000 sq ft headquarter based in Shanghai and a total of 5 global manufacturing sites and 2 R&D centers worldwide, having more than 1500 staff including top professionals with strong Biotech industry background. GL Biochem is able to provide high-quality, value-added, and high-tech peptide-related products through strong and diverse capability, and more than 13 years’ excellent management experience and economy of scale. Peptide reagents and building blocks  Peptide coupling reagents: BOP reagent, HBTU, HOBt, TBTU  Fmoc-amino acids, Boc-Amino Acids, Z-Amino Acids  Protecting reagents: Fmoc-Cl, Fmoc-OSu  Linkers for solid-phase synthesis: HMP linker, DHP linker, Rink amide linker  Unusual amino acids: Homo-tyrosine, DL-m-tyrosine, Nal, Pal, 4-Cl-Phe-OH  Generic Peptide: Octreotide...  cGMP Peptide Custom services  Custom Organic Synthesis  Custom Peptide Synthesis  Custom antibody service  Contract Research/Manufacture  Full-Time Employee

196 Broadway Cambridge, MA, 02139 United StatesGNS Healthcare’s Subpopulation tool allows biopharma to run a complete trial dataset and quickly identify predictive biomarkers to select patients with a high probability of treatment benefit in a follow-up trial. It also prioritizes prognostic biomarkers that identify disease drivers that when perturbed show a change in the outcome of interest. The GNS Subpopulation tool: • Identifies a set of predictive response biomarkers • Determines confounding variables and removes them from analysis • Allows the user to optimize the set of biomarkers by varying cut- points and the ability to visualize the impact on the corresponding hazard ratios and information on the biomarker prevalence • Prioritizes prognostic biomarkers to identify disease drivers The Subpopulation tool eliminates the time-consuming current methods of biomarker selection, allowing scientists to explore all potential biomarkers and select the most relevant predictive biomarkers for a trial. The tool accelerates the process of preparing for later phase trials by reducing biomarker discovery from months to weeks. The REFS Advantage The REFS causal machine learning platform can be an integral part of your subpopulation identification process by: • Using retrospective analysis to generate biomarker hypotheses • Identifying predictive biomarkers to enrich patients in clinical studies • Using data to understand disease progression and treatment impact • Performing interim analysis to refine biomarker choice and adjust trials • Employing causal models to improve clinical trial analysis • Continuously validating and improving causal models using

350 Third Street Suite 2011 Cambridge, MA, 02142 United StatesGemedy's technologies enables organizations to strengthen their strategic positions by using machine learning and data science software to detect hidden networks and pathways in biological systems. The Gemedy SKEIN tool visualizes any uncovered networks of influence and provides recommendations for either leveraging or counteracting those networks.

840 Memorial Drive Fifth Floor Cambridge, MA 02139 USAGen9 is the premier next-generation gene synthesis company focused on high-quality, high-throughput, automated production of DNA constructs. As a scalable high-throughput gene synthesis process that delivers clonal, sequence-perfect constructs from 300 to 10,000bp at the lowest cost, there are certain guidelines that Gen9 provides to take advantage of the technology. The minimum order quantity is 20,000 bp. Gen9 provides DNA constructs, dried down, in 1 microgram quantities on 96-well plates. Gen9's philosophy is order more constructs up front, so that you are more likely to get the end products that you need faster. Build more each round of the design-build-test cycle to reduce the number of cycles and shorten project time overall.

840 Memorial Drive United States Cambridge, Massachusetts, 02139 United StatesGen9 is the premier next-generation gene synthesis company focused on high-quality, high-throughput, automated production of DNA constructs. As a scalable high-throughput gene synthesis process that delivers clonal, sequence-perfect constructs from 300 to 10,000bp at the lowest cost, there are certain guidelines that Gen9 provides to take advantage of the technology. The minimum order quantity is 20,000 bp. Gen9 provides DNA constructs, dried down, in 1 microgram quantities on 96-well plates. Gen9's philosophy is order more constructs up front, so that you are more likely to get the end products that you need faster. Build more each round of the design-build-test cycle to reduce the number of cycles and shorten project time overall.

164 Fredette St, Gardner, MA 01440Garlock Printing & Converting Corp. is committed to producing a safe, legally compliant, quality product that meets our customers’ expectations. This is achieved through our quality systems and processes, our employees’ high level of expertise, and by a dedication to continuous improvement and training.

500 Kendall Street Cambridge, MA 02142 USAGenzyme specializes on creating pharmaceutical products to treat rare diseases and multiple sclerosis.

Newton, MA, USAGeny Research offers regulatory affairs, drug registration, screening, compound efficacy, and drug studies.

Boston, MA, USAGenetix, now part of Molecular Devices, offers screening, genetic services, reagents, imaging, and lab materials.

Cambridge, MA, USAGGA Software offers software development services.

100 Acorn Park Drive Cambridge, MA, 02140 United StatesGenocea Biosciences is harnessing the power of T cell immunity to develop the next generation of vaccines.

One Innovation Drive Worcester, MA 01605 USAGLSynthesis offers custom organic synthesis, computer aided drug design, in vivo/in vitro testing, and fine chemical/reagent products and services.

50C Audubon Road Wakefield, MA 01880Neuroscience discovery and development are undergoing dramatic change. Late stage clinical failures have forced the field to reevaluate the tools and hypotheses which have been used to design and develop drugs for central nervous system (CNS) disorders for the past 25 years. A number of key challenges have been identified: Complex CNS diseases, which are caused by the interplay between many genes and pathways, are unlikely to be effectively treated using drugs which target a single protein. The battery of standardized laboratory rodent models of behavior is far from optimal in predicting human clinical outcomes. Clinical trials of CNS drugs are hampered by the lack of objective measures of disease state and drug effects. At Galenea, we believe that each of these significant challenges can be addressed by a focus on synaptic transmission — the means by which signals are transmitted from neuron to neuron and across dense networks in the brain. Dysfunctions in synaptic transmission are key elements in Alzheimer's disease (AD), Parkinson's disease, Huntington's disease, epilepsy, bipolar depression, schizophrenia, autism spectrum disorders, and traumatic brain injury. And in neurodegenerative disorders such as AD, changes at the synapse appear very early in the disease.

One Kendall Square Building 200 Suite 3 Cambridge, MA 02139 USAGenometry is a platform-technology company founded by a multidisciplinary team of genome scientists to commercialize a revolutionary genome-wide high-throughput low-cost gene-expression profiling method (L1000) for next-generation pharmaceutical discovery applications.

24 Denby Rd, Suite 217 Boston, MA 02134 USAHMT-America develops and offers mass spectrometry-based metabolic profiling services. Our unique CE-MS and LC-MS platforms provide quantitative and untargeted measurements for primary metabolism and profiling for many types of samples and applications. Based on statistical, multivariate and pathway analyses, our research coordinators support the study design and biological interpretation.

24 Denby Road Suite 217 Boston, MA, 02134 United StatesHMT-America develops and offers mass spectrometry-based metabolic profiling services. Our unique CE-MS and LC-MS platforms provide quantitative and untargeted measurements for primary metabolism and profiling for many types of samples and applications. Based on statistical, multivariate and pathway analyses, our research coordinators support the study design and biological interpretation.

100 Cummings center Suite 360B Beverly, MA, 01915 United StatesHepatochem is a C-H Activation technology company that clients engage for (a) rapid, single-step synthesis of metabolites [Phase I: N/S-oxidation, N/O-demethylation, hydroxylation, formylation; and, Phase II: Glucuronidation] in up to 100 mg quantities (b) rapid analoging [C-H to C-F, C-OMe, C-OH, and/or C-Me] of late stage lead(s) to help address DMPK liabilities or explore SAR. Hepatochem also sells 'fully functionalized' chemistry kits that scientists can use to screen in their own labs for (a) best conditions to synthesize metabolite of interest, (b) Suzuki coupling, (c) Stille coupling, (d) Buchwald coupling, and (e) amide coupling.

100 Cummings Center, Suite 424J Beverly, MA 01915Hepatochem is a C-H Activation technology company that clients engage for (a) rapid, single-step synthesis of metabolites [Phase I: N/S-oxidation, N/O-demethylation, hydroxylation, formylation; and, Phase II: Glucuronidation] in up to 100 mg quantities (b) rapid analoging [C-H to C-F, C-OMe, C-OH, and/or C-Me] of late stage lead(s) to help address DMPK liabilities or explore SAR. Hepatochem also sells 'fully functionalized' chemistry kits that scientists can use to screen in their own labs for (a) best conditions to synthesize metabolite of interest, (b) Suzuki coupling, (c) Stille coupling, (d) Buchwald coupling, and (e) amide coupling.

100 Cummings Center, Suite 424J Beverly, MA 01915Hepatochem is a C-H Activation technology company that clients engage for (a) rapid, single-step synthesis of metabolites [Phase I: N/S-oxidation, N/O-demethylation, hydroxylation, formylation; and, Phase II: Glucuronidation] in up to 100 mg quantities (b) rapid analoging [C-H to C-F, C-OMe, C-OH, and/or C-Me] of late stage lead(s) to help address DMPK liabilities or explore SAR. Hepatochem also sells 'fully functionalized' chemistry kits that scientists can use to screen in their own labs for (a) best conditions to synthesize metabolite of interest, (b) Suzuki coupling, (c) Stille coupling, (d) Buchwald coupling, and (e) amide coupling.

100 Cummings Center Suite 424J Beverly, MA, 01915 United StatesHepatochem is a C-H Activation technology company that clients engage for (a) rapid, single-step synthesis of metabolites [Phase I: N/S-oxidation, N/O-demethylation, hydroxylation, formylation; and, Phase II: Glucuronidation] in up to 100 mg quantities (b) rapid analoging [C-H to C-F, C-OMe, C-OH, and/or C-Me] of late stage lead(s) to help address DMPK liabilities or explore SAR. Hepatochem also sells 'fully functionalized' chemistry kits that scientists can use to screen in their own labs for (a) best conditions to synthesize metabolite of interest, (b) Suzuki coupling, (c) Stille coupling, (d) Buchwald coupling, and (e) amide coupling.

450-C Donald Lynch Blvd Marlborough, MA, 01752 United StatesStageBio provides necropsy, histology, veterinary pathology evaluation, immunohistochemistry, neuropathology, medical device, morphometry, whole slide scanning and archiving outsourcing support to the drug discovery companies. We work with a variety of species including: hamsters, mice, rats, ferrets, guinea pigs, rabbits, dogs, pigs, sheep and non-human primates.

450 Donald Lynch Blvd Suite C Marlborough, MA, 01752 United StatesStageBio provides necropsy, histology, veterinary pathology evaluation, immunohistochemistry, neuropathology, medical device, morphometry, whole slide scanning and archiving outsourcing support to the drug discovery companies. We work with a variety of species including: hamsters, mice, rats, ferrets, guinea pigs, rabbits, dogs, pigs, sheep and non-human primates.

Cambridge, MA, USAHybrigenics Services is a complete service provider of cutting-edge technologies dedicated to the study of proteins and their interactions in 35+ organisms and any research thematic. We offer three main lines of services: • Interactions Discovery: ULTImate Y2H™ to discover novel protein-protein interactions in various tissues/cell types o Several adapted versions allow to identify interactions with transmembrane proteins, DNA and RNA o Associated services: Interaction Domain Mapping, Low binders, super binders • Drug Discovery Services (Adapted from ULTImate Y2H) o Target deconvolution: ULTImate YChemH™ to identify on- and off-targets of small bioactive molecules - mechanism of action, polypharmacology, drug repositioning, prediction of toxicity o Protein-protein interactions induced by molecular glues (protein stabilization, targeted protein degradation) • Nanobody® (or Synthetic Antibodies, VHH) to select and validate high-affinity single-domain antibodies (Hybribody™) - for IF, ELISA, high-resolution microscopy, video-microscopy, target inhibition applications but also for diagnosis and therapeutic purposes Our optimized screening platform in yeast enables the identification of the protein partners of proteins, DNA sequences, RNA and small molecules of therapeutic interest. Highly complex protein domain libraries, prepared from any cell type or tissue, are screened to saturation to identify partners and their interacting domains using a transcriptional read-out. Sophisticated bioinformatics analysis allows to attribute confidence scores to each interaction. With more than 3,200 academic and industrial customers from over 40 countries, Hybrigenics Services is internationally recognized. Among our services, our yeast two-hybrid screening technology, ULTImate Y2H, is extensively used in many research projects. The results obtained at Hybrigenics have been quoted in more than 480 scientific publications to date. Hybribody offers single-domain antibody selection and validation services. We handle the in vitro selection of antibodies against your protein from a fully synthetic humanized VHH library by an optimized Phage Display technology. VHHs have the advantages of being very small (15 kDa), affine and stable molecules. We validate the selected VHHs for in vitro and in vivo applications (ELISA, IF, Intrabody…). We can also fuse the VHH with Fc fragments from the species of your choice to deliver fully functional recombinant antibodies. In addition, Hybrigenics Services provides optimization of nanobodies coming from the Llama using yeast display technology. Nanobody® is a trademark of Ablynx.

940 Winter St Waltham, MA, 02451 United StatesSingle-cell genomic platform for the collection, storage, and profiling of clinical samples.

649 Massachusetts Avenue Cambridge, MA, 02139 United States

649 Massachusetts Ave, Suite 6 United States Cambridge, MA, 02139 United States

Cambrigbe, MAThe Harvard Brain Tissue Resource Center has been established at McLean Hospital as a centralized resource for the collection and distribution of human brain specimens for brain research. Research over the past decade has shown that the study of human brain tissue is essential to increasing our understanding of how the nervous system functions. Most recently, postmortem human brain research has played a significant role in the development of a genetic test for Huntington's disease as well as a treatment for Parkinson's disease. Similarly, neurochemical and anatomical studies focusing on the biological nature of the severe mental illnesses are now emerging and bringing forth new hope for understanding the underlying brain mechanisms responsible for psychosis and other symptoms associated with these debilitating brain disorders. In order to perform research into the neurological or psychiatric disorders, it is vital to collect normal control tissue as well.

104 Mt. Auburn Street, 3rd Floor Cambridge, MA 02138

25 Shattuck Street Boston, MA 02115 USAHarvard Medical School Systems Biology Flow Cytometry Facility offers flow cytometry and cell sorting training and services.

45 Moulton Street Cambridge, MA, 02138 United StatesHydra Biosciences, a biopharmaceutical company based in Cambridge, Massachusetts, develops novel drugs to treat pain, inflammation, anxiety and other diseases using its expertise in novel ion channels.

Confocal Imaging Core Beth Israel Deaconess Medical Center Dana 814 330 Brookline Avenue Boston, MA 02215 The function of the Confocal Core is to provide services in confocal microscopy, light microscopy and immunostaining for cells and tissues.

Boston, MA, 02215 United States The function of the Confocal Core is to provide services in confocal microscopy, light microscopy and immunostaining for cells and tissues.

New Research Building Room 336 77 Avenue Louis Pasteur Boston, MA 02115 USAHarvard Medical School's Drosophila RNAi Screening Center (DRSC) offers RNAi screening, Drosophila cell culture, RNAi libraries, and dsRNA synthesis services.

Boston, MA United StatesHarvard Medical School's Drosophila RNAi Screening Center (DRSC) offers RNAi screening, Drosophila cell culture, RNAi libraries, and dsRNA synthesis services.

930-W Commonwealth Avenue Boston, MA 02215 USAHarvard Clinical Research Institute offers clinical research services including biostatistics, data management, project management, trial design, and ECG analysis services.

One Cambridge Center Cambridge, MA 02142-1612 USAHammer and Company is a business education and research firm that focuses on cutting-edge issues in operations, organization, and management.

Goldenson Building 323 220 Longwood Avenue Boston, MA 02115The Harvard Medical School EM Facility is a fee-for-service core facility open to researchers in the HMS Quadrangle and the Longwood Medical area. The Facility provides services and supervision in Transmission Electron Microscopy.

220 Longwood Avenue Goldenson building 323 Boston, MA, 02115 United StatesThe Harvard Medical School EM Facility is a fee-for-service core facility open to researchers in the HMS Quadrangle and the Longwood Medical area. The Facility provides services and supervision in Transmission Electron Microscopy.

Boston, MA United StatesThe Biopolymers Facility is a non-profit technology service center in the Department of Genetics at Harvard Medical School. The investigators at Harvard Medical School make up the primary client base of the BPF. Through the University's partnerships with surrounding hospitals and research organizations we also serve labs throughout the entire Longwood Medical Area (LMA). While the majority of our users are from the LMA we also serve labs at schools, universities and biotechnology companies from all across the world.

118 Main St Store Front Webster, MA - MASSACHUSETTS, 01570 United StatesHistologistics offers histology, immunohistochemistry, and microscopy services.

12 Oxford Street Cambridge, MA, 02138

84 October Hill Road Holliston, MA, 01746 United States

One Kendall Square, Building 200 Cambridge MA 02139 USAHelicos BioSciences provides genetic analysis kits, image analysis, and gene services.

7 Divinity Avenue Cambridge, MA, 02138 United States

60 Oxford St 4th Floor, Suite 403 Cambridge, MA 02138The Wyss (pronounced "Veese") Institute for Biologically Inspired Engineering uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Tufts University, and Boston University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs. By emulating Nature's principles for self-organizing and self-regulating, Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and new start-ups.

665 Huntington Ave Building 1, Room 1301 Boston, MA 02115 USAHarvard School of Public Health - National institute of Environmental Health Sciences (NIEHS) offers its core facilities to provide biological analysis, environmental genomics, environmental analysis, and biostatistics/bioinformatics services.

1380 Soldiers Field Road Boston, MA, 02135 United StatesHumedica is the clinical intelligence company that powers health care providers and life sciences organizations to make better-informed, more confident decisions by transforming unconnected data from multiple sources into real-world insights.

266 Summer Street Boston, MA, 02210 United StatesA company with a culture of great ideas and close collaboration and passion to always do what is right for our clients. We have been assembling the strongest life science consulting team in the business for more than two decades. Attracting the best people is a product of thought leadership, but also of culture.

10 Shattuck Street, Boston, MA 02115Harvard Catalyst provides bioinformatics, cell culture manipulation, imaging, genetics, DNA synthesis and sequencing, histology, microarray, antibody, peptide, crystallography, PCR, RNAi screening, stem cells, transgenics, and viral services.

114 16th Street Boston, MA, 02129 United StatesThe Harvard NeuroDiscovery Center is a pioneering biomedical research group focused on ending suffering from neurodegenerative diseases

100 Barber Avenue Worcester, MA 01606 USAHypromatrix offers antibody arrays, antibodies, protein-protein interaction screening, gene cloning/expression, and protein purification services.

84 October Hill Road Holliston, MA, 01746 United StatesHarvard Apparatus provides syringe pumps, ventilators, amplifiers, and glassware.

Flow Cytometry Core Beth Israel Deaconess Medical Center Center for Life Science, CLS-0932 330 Brookline Ave Boston, MA 02215Committed to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting.

Boston, MA, 02215 United StatesCommitted to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting.

240 Longwood Avenue Boston, MA 02115 USAHarvard Department of Cell Biology focuses on research and offers its microscopy and mass spectrometry facilities.

3 Woodland Road First Floor Stoneham, MA 02180

3 Woodland Road Stoneham, MA, 02180 United States

Lawrence, MA, USAHooke Laboratories is a fast-growing biotechnology service and product company in Lawrence, Massachusetts, USA. We were founded by immunologist Suzana Marusic, M.D., Ph.D. in 2007. The company is named after Robert Hooke, F.R.S. (1635-1703), the world's first professional scientist and discoverer of the cell. We have three complementary lines of business supporting in vivo and ex vivo research worldwide. Hooke Laboratories is a full-service pre-clinical CRO specializing in rodent models of inflammation and autoimmune diseases. Our CRO customers include leading international pharmas, venture-funded biotechs, universities and small startups. Our product customers are even more diverse and include university, foundation, and commercial scientists in more than 40 different countries. Our product business offers potency-characterized emulsion kits, antigens, tissues, and reagents to researchers worldwide. As of early 2019, Hooke products have been cited in over 400 peer-reviewed scientific publications (and growing!). We have most recently expanded our offerings to include ex vivo services – extending our capabilities in histology, immunohistochemistry, cytokine analysis and flow cytometry more broadly to the research community. Hooke Laboratories is always interested in offering new products and running new projects, within our expertise, that will help advance research - contact us to discuss your needs!

439 South Union Street Lawrence, MA, 01843 United StatesHooke Laboratories is a fast-growing biotechnology service and product company in Lawrence, Massachusetts, USA. We were founded by immunologist Suzana Marusic, M.D., Ph.D. in 2007. The company is named after Robert Hooke, F.R.S. (1635-1703), the world's first professional scientist and discoverer of the cell. We have three complementary lines of business supporting in vivo and ex vivo research worldwide. Hooke Laboratories is a full-service pre-clinical CRO specializing in rodent models of inflammation and autoimmune diseases. Our CRO customers include leading international pharmas, venture-funded biotechs, universities and small startups. Our product customers are even more diverse and include university, foundation, and commercial scientists in more than 40 different countries. Our product business offers potency-characterized emulsion kits, antigens, tissues, and reagents to researchers worldwide. As of early 2019, Hooke products have been cited in over 400 peer-reviewed scientific publications (and growing!). We have most recently expanded our offerings to include ex vivo services – extending our capabilities in histology, immunohistochemistry, cytokine analysis and flow cytometry more broadly to the research community. Hooke Laboratories is always interested in offering new products and running new projects, within our expertise, that will help advance research - contact us to discuss your needs!

Horizon Discovery Inc. 245 First Street, Third Floor Cambridge, MA 02142 U.S.ABuilt upon decades of experience engineering cell lines, RNA synthesis, and bioinformatic design, we have created a unique portfolio of reagents and services that empower researchers to push their work forward with data generated from cell models. Horizon is leveraging its technological expertise to provide cell engineering tools and services to its customers in three key areas of the therapeutic ecosystem: basic research, drug discovery and development and therapeutic applications. Some of our central services include: • Screening & Cell line engineering services: tools and services that are designed to improve the outcome of drug discovery and development • BioProduction cell lines: engineered CHO cell lines that are designed to enable efficient biologics manufacturing Horizon’s customers include biopharmaceutical and diagnostics companies, contract research and manufacturing organizations and academic researchers across the globe. Horizon sells its tools and services to more than 2,000 unique customers in over 60 countries, including to 19 of the 20 largest biopharmaceutical companies by revenue. On the contract research front, Horizon’s service group supports researchers with cell line engineering, functional genomic screening, high-throughput immuno-oncology assays, compound profiling, drug combination screening, using CRISPR, or siRNA for a variety of cell-based assays.

450 Bedford Street Lexington, MA 02420 USA-Single Source for a vast network of sample and data access -Remnant Biospecimens -Consented biobanked specimens -Custom collections -Blood and blood derivatives -Tissue - fresh, frozen, viable, FFPE -NGS Tissue and biofluids -Cells -Vast clinical Data

450 Bedford Street, Suite 1010 United States Lexington, Massachusetts, 02420 United States-Single Source for a vast network of sample and data access -Remnant Biospecimens -Consented biobanked specimens -Custom collections -Blood and blood derivatives -Tissue - fresh, frozen, viable, FFPE -NGS Tissue and biofluids -Cells -Vast clinical Data

Ten Post Office Square, Floor 8, Boston, MA 02109

60 Hampshire Street Cambridge MA 2139 USAIdenix provides discovery and development of drugs for viral and infection diseases such as Hepatitis C and HIV.

Cambridge, MA United StatesIdenix provides discovery and development of drugs for viral and infection diseases such as Hepatitis C and HIV.

43 Vassar Street, Cambridge, MA 02139, USThe Laboratory for Computational and Statistical Learning (LCSL) is the result of a collaborative agreement between the Istituto Italiano di Tecnologia and the Massachusetts Institute of Technology. Our aim is to advance the frontiers of learning theory and machine learning, while building algorithmic tools for the analysis of complex systems and high dimensional data. Our approach blends well established concepts and methods from computer science, statistics and signal processing with modern results in (high dimensional) probability, into new computational tools for statistical inference. Our goal is to channel theory and algorithms into new applications including smarter technologies and sophisticated engines for inference from high-dimensional data/signals. The ultimate objective of the lab is a future generation of intelligent technologies.

MIT Bldg. 46-5155 43 Vassar Street Cambridge, MA United StatesThe Laboratory for Computational and Statistical Learning (LCSL) is the result of a collaborative agreement between the Istituto Italiano di Tecnologia and the Massachusetts Institute of Technology. Our aim is to advance the frontiers of learning theory and machine learning, while building algorithmic tools for the analysis of complex systems and high dimensional data. Our approach blends well established concepts and methods from computer science, statistics and signal processing with modern results in (high dimensional) probability, into new computational tools for statistical inference. Our goal is to channel theory and algorithms into new applications including smarter technologies and sophisticated engines for inference from high-dimensional data/signals. The ultimate objective of the lab is a future generation of intelligent technologies.

34 Bear Hill Rd. Waltham, MA 02451 USAIntelligent Bio-Systems develops and offers their proprietary DNA sequencing instrument, the MaxSeq high throughput sequencing by synthesis system.

410 Great Road Littleton, MA 01460 USAIntegral BioSystems specializes in drug delivery and drug development services.

Littleton, MA United StatesIntegral BioSystems specializes in drug delivery and drug development services.

830 Winter Street Waltham , MA, 02451-1477 United States

210 Broadway Cambridge, MA, 02139 United StatesMRI based biomarkers for Neuro-Inflammation, Demyelination/Remyelination and Axonal death. We process diffusion MRI images to assess white matter and connectivity as part of neurodegenerative diseases and brain research. We can provide endpoints such as neuro-inflammation based on MRI, white matter volume and other advanced tractography and tractometry tools. We are the right team for MRI studies that involve white matter neuro-inflammation, degeneration and demyelination/remyelination. Our services are based on image processing with automated software and we also offer imaging site qualification and training, imaging protocol design, image analysis and statistics.

Waltham, MA, USAInnoCentive is a portal that enables scientists, engineers, professionals and entrepreneurs to collaborate to deliver solutions to real problems.

39 Grant St. #400 Framingham, MA, 01702 United StatesIQ Proteomics was founded in 2015 with a goal to provide uncompromising quantitative proteomic services and applications. Our founders have over 15 years of combined specialized quantitative proteomics expertise.

840 Memorial Drive Cambridge , MA , 02139 United StatesIQ Proteomics was founded in 2015 with a goal to provide uncompromising quantitative proteomic services and applications. Our founders have over 15 years of combined specialized quantitative proteomics expertise.

115 4th Ave Needham, MA, 02494 United StatesHeadquartered in Needham, MA, Invicro, a subsidiary of REALM IDx, was founded in 2008 with the mission of improving the role and function of imaging in translational drug discovery and development. Today, Invicro’s multi-disciplinary team provides solutions to pharmaceutical and biotech companies across all stages of the drug development pipeline (Preclinical through Phase 0-IV), all imaging modalities and all therapeutic areas. Invicro’s quantitative biomarker services, pathology solutions, advanced analytics and AI tools, and clinical operational services are backed by Invicro’s industry-leading software informatics platforms, VivoQuant® and iPACS®, as well as their pioneering IQ Analytics Platform, which includes Amyloid-IQ, Tau-IQ and DaT-IQ. Invicro operates out of nine global laboratories, clinics and sites within the United States in Massachusetts, Michigan, California, Connecticut and globally in the United Kingdom, India, Japan and China. Learn more by visiting www.invicro.com

4 TECHNOLOGY WAY Salem, Massachusetts, 01970 United StatesiHisto seeks to promote affordable and quality experiments for all laboratory and research purposes. We strive to grow and create an accessible business for all of your histopathology needs. Our goal is to meet client expectations and to exceed them to the fullest extent.

21C Olympia Ave Woburn, MA, 01801 United StatesiHisto seeks to promote affordable and quality experiments for all laboratory and research purposes. We strive to grow and create an accessible business for all of your histopathology needs. Our goal is to meet client expectations and to exceed them to the fullest extent.

Branch Office: One Broadway, 14th Floor, Cambridge, MA 02142Integrated Resource Inc (IRI) is a nimble and efficient Clinical Research Organization (CRO) committed to provide comprehensive clinical research solutions to Pharmaceutical, Biotechnology and Medical device companies. We specialize in End to End Clinical Trial Management services for early phase (Phase I & II) or late phase (Phase III & IV) of drug development. Integrated Resources is committed to deliver Timely and Quality services being most cost effective service partner with Wide Spread Global Network and associated partners to support the hassle free project execution. We operate in best compliance with Good Clinical Practice, Good Manufacturing Practices, US FDA Code of Federal Regulations, EU Directives and other regulatory guidelines.

One Broadway, 14th Floor, Cambridge, MA 02142 USAIntegrated Resource Inc (IRI) is a nimble and efficient Clinical Research Organization (CRO) committed to provide comprehensive clinical research solutions to Pharmaceutical, Biotechnology and Medical device companies. We specialize in End to End Clinical Trial Management services for early phase (Phase I & II) or late phase (Phase III & IV) of drug development. Integrated Resources is committed to deliver Timely and Quality services being most cost effective service partner with Wide Spread Global Network and associated partners to support the hassle free project execution. We operate in best compliance with Good Clinical Practice, Good Manufacturing Practices, US FDA Code of Federal Regulations, EU Directives and other regulatory guidelines.

32 Whitman Bailey Dr Auburn, Massachusetts, 01501 United StatesTrial Insights, a digital reporting solution that simplifies data produced through clinical trial, biomarker and medical diagnostic studies into an intuitive and user-friendly dashboard. The first of its kind, Trial Insights curates publicly available data nightly from information hubs such as clinicaltrials.gov and customizes it to fit a researcher or research organization’s specific project needs. “Trial Insights offers researchers an easy way to navigate the complexity of clinical trials information," said Ron Ranauro, Founder of Incite Advisors.“Since Trial Insights’ content is digitally curated, researchers can continuously keep track of the evolving landscape of drugs, diseases, sponsors, investigators and medical devices important to their work.” As the velocity, variety and veracity of data available on sites like clinicaltrials.gov continues to increase, the ability to curate it becomes more valuable to different audiences. With the advancement of personalized medicine, it is important to make the data accessible to the health care and patient communities. Information found on the Trial Insights platform can help guide decision making across the pharmaceutical, biotechnology and contract research organization industries as clinical trial data is a primary information source for competitive intelligence, research planning and clinical study planning.

26 Forest Street Marlborough, MA, 01752 United StatesImmunovia’s innovative multiplexing technology (IMMrayTM) uses a single drop of serum to simultaneously measure 400+ biomarkers and provide condensed diagnostic-, prognostic- and predictive biomarker signatures. The company Immunovia has been a listed company since 2015, with shares (as IMMNOV), traded on Nasdaq First North in Stockholm and now heading for the Nasdaq Stockholm main-list (Q1 2018). The company has 40+ employees, is headquartered in Lund, Sweden; and is currently setting up reference labs in both Lund, Sweden, and Boston, USA. Technology IMMray™ is a versatile and robust platform technology for performing clinical serum proteomics, developed and optimized over 17 years at Lund University/Create Health. In contrast to genomics microarray technologies (e.g. NGS) that measure the potential risk of a future disease/drug (Rx) response, IMMray™ multiplexes the patient serum proteome and assesses the actual current state of the disease/treatment response. The arrays are developed from a proprietary set (currently 970) recombinant single chain fragment variant (scFV) antibodies from our own phage-display library and are able to detect changes in immuno-regulatory factors, cytokines, enzymes, complement proteins, innate factors, and cancer associated proteins. Diagnostic workflow IMMray™ is optimized for routine diagnostic lab workflows with three day’s turnaround time (TAT) from patient sample received to test report. Disease areas IMMrayTM has shown its applicability within two main disease areas – oncology (pancreatic) and autoimmune s (rheumatoid arthritis, Systemic Lupus Erythematosus, vasculitis, Sjogrens Syndrome). The key advantages, using IMMrayTM includes the ability to work with serum samples as opposed to biopsies, and, the achievement of very high clinical sensitivities and specificities to successfully differentiate between phenotypically similar indications. Our pharma offerings For our pharma partners, we design Customized Discovery Chips and IMMray™ CDx Test solutions for patient cohort dichotomization. After an initial survey of our 400+ serum biomarkers, we use our proprietary bioinformatics tools to derive a specific condensed signature/algorithm of 5-35 proteins capable of differentiating patients into sub-cohorts. This enables patient selection with sensitivities and specificities above 95%. Initially, IMMray™ product testing will be performed through our reference laboratories in Lund, Sweden and Boston, USA.

100 Cummings Center 100 Cummings Center, suite 451C Beverly, MA, 01915 United StatesINOVOTION is a biotech company which offers you a unique in vivo technology dedicated to oncology efficacy studies and early toxicity evaluations. Our Fast, Sensitive, Reliable and Affordable assay will save you time and money, to give you a clear competitive advantage. This breaking-thought technology, based on chick embryo, provides early analysis of your treatments before the classical preclinical stages. By eliminating low-value molecules early, INOVOTION accelerates your drug discovery process, increases your R&D productivity and reduces its costs. It’s rapid Go/No Go decision with multi-cancer screening capacities. This next generation of in vivo efficacy and toxicity tests covers fours main aspects: - EFFICACY assays for your anti-cancer treatments - EARLY TOXICITY assays for your drug candidates - TARGET VALIDATION in oncology - MULTI-CANCER SCREENING to (re)positioning your treatment We help chemists and biologists from companies and universities to validate a target and develop treatments by getting them through in vivo evaluation, while staying within their budget. These accessible efficacy and toxicity assays open really new perspectives of screening for wide variety of project researches.

Wakefield, MA, USAInterchem provides regulatory support, contracting expertise, custom intermediates and APIs.

Walpole, MA United StatesIridium Biosciences provides corporate and scientific management.

51 Sawyer Rd., Ste. 200 Waltham, MA 02453 United StatesInverness Medical provides biomarker discovery, women's health products, infectious disease, and diagnostic product manufacturing.

700 Nickerson Road Marlborough, MA 01752 USAIQuum provides equipment for the extraction of information from biological samples.

Marlborough, MA United StatesIQuum provides equipment for the extraction of information from biological samples.

Pittsfield, MA, 01201 United StatesIntertek Plastics Technology Laboratories provides mechanical, rheological, electrical, and optical testing for plastics.

3 Forbes Road Lexington, MA 02421ImmuneXcite is a privately held biotech company based in Lexington, Mass., that is developing the next generation of immune-activating, anti-tumor biotherapeutics against a wide range of cancers. The company’s near-term business objective is to select a lead program within its discovery pipeline and then advance this program into the clinic by early 2018. Given the potential breadth of the company’s technology, its intention is to leverage the strength of the mAbXcite platform with a select group of biopharmaceutical partners. In 2015, ImmuneXcite established undisclosed early-stage collaborations with two of the leading biopharmaceutical companies in the immuno-oncology space.

825 University Ave, Norwood, MA, 02062-2643, US

P.O. Box 414525 Boston, MA, USA 02241-4525IBC Life Sciences leads expert-led conferences for pharmaceutical, biotechnology, academics and government organizations with a specialization in antibodies, oligonucleotides, proteins/peptides and vaccines.

Boston, MA, USAICCB-Longwood offers RNAi screening, library, imaging and PCR services.

Boston, MA United StatesICCB-Longwood offers RNAi screening, library, imaging and PCR services.

1 Presidential Way, Suite 104 Woburn, MA 01801 USAImmunoDiagnostics supplies recombinant proteins, antibodies, immunoassay kits, and other conjugated products.

7 New Lancaster Road, Leominster • MA USA 01453IMA Non-Pharma sector includes divisions and companies that are recognised as leaders within their individual markets: Tea & Herbs Division for packaging tea, herbs and coffee in filter bags and pods; Gima SpA for packaging tea and coffee in capsules, chewing gum and sweets in innovative packs, and for the high level of assembly technology; FillShape Srl for filling in stand-up pouches; Gima TT Srl for smart and flexible packaging technologies; Corazza SpA specialised in lines for soup cubes, butter and processed cheese in various formats; BFB Division with its wide range of end of line machines; and Revisioni Industriali Srl for perfectly overhauled second-hand machines.

405 Waltham Street Lexington, MA02421 USADespite tremendous progress in basic science, there have been no new breakthroughs in the treatment of many CNS diseases. CNS quantitative systems pharmacology is based on the realization that human pathology is driven by a network imbalance rather than deficits at a single target or gene. Computer-based modeling of biophysically realistic neuronal network circuits calibrated with human imaging and clinical data is a translational tool to assess the outcome of therapeutic interventions in complex brain circuits. The company provides insights into the systemic behavior at each R&D stage in high impact decision processes. We provide model based decision support and knowledge support from target validation to personalized medicine for Schizophrenia (PANSS Total, PANSS Negative, Cognitive Impairment) Antipsychotic-induced side effects (Extra-pyramidal symptoms, Akathisia, Prolactin increase) Alzheimer's disease (Cognition, Neuropsychiatric symptoms and Beta-amyloid dynamics) Parkinson's disease (Rigidity-bradykinesia, Tremor, L-DOPA induced dyskinesia) Our modeling addresses the following key questions Target validation Clinical candidate selection Support rationally designed multipharmacology drug discovery projects Rational support for combination therapy Clinical biomarker selection for functional target engagement Dosing guidance Clinical study design especially with comedications and genotypes Competitive analysis Clinical responder analysis

301 Binney Street Cambridge, MA, 02142 United StatesIronwood is committed to the art and science of making medicines.

33 Hayden Avenue 2nd Floor Lexington, Massachusetts 02421 USAInotek Pharmaceuticals produces products to address the unmet medical needs in significant diseases of the eye.

Lexington, MA United StatesInotek Pharmaceuticals produces products to address the unmet medical needs in significant diseases of the eye.

Wellman Center for Photomedicine Massachusetts General Hospital 50 Blossom St., BAR 818 Boston, MA 02114We develop technologies using photons to probe life sciences, visualize health, and treat diseases. In turn, we use biological matters to control light and create new living optical functions. Taking multidisciplinary approaches, this research spans a wide spectrum from satisfying our intellectual curiosity to solving real-world problems. The Bio-Optics Lab Harvard University, Harvard Medical School Wellman Center for Photomedicine, Massachusetts General Hospital Harvard-MIT Health Sciences and Technology

Partners Research Building Wellman Center for Photomedicine 65 Landsdowne St. UP-525 Cambridge, MA 02139We develop technologies using photons to probe life sciences, visualize health, and treat diseases. In turn, we use biological matters to control light and create new living optical functions. Taking multidisciplinary approaches, this research spans a wide spectrum from satisfying our intellectual curiosity to solving real-world problems. The Bio-Optics Lab Harvard University, Harvard Medical School Wellman Center for Photomedicine, Massachusetts General Hospital Harvard-MIT Health Sciences and Technology

258 Main Street, Suite 202 Milford, MA 01757International Chemistry Testing, Inc. (“ICT”) is a premier independent laboratory that provides unique chemistry services for life science, food and dietary supplements, cosmetics, biotechnology and pharmaceutical industries. We specialize in the areas where competitors cannot handle due to our in-depth of knowledge and breadth of experience. Our specialities include botanical ingredient authentication, phyto-bioactivities , polyphenol chemistry and free radical chemistry. Botanical reference materials and customer assay development are also part of the portfolio of our services.

258 Main Street, Suite 202 Milford, MA, 01757 United StatesInternational Chemistry Testing, Inc. (“ICT”) is a premier independent laboratory that provides unique chemistry services for life science, food and dietary supplements, cosmetics, biotechnology and pharmaceutical industries. We specialize in the areas where competitors cannot handle due to our in-depth of knowledge and breadth of experience. Our specialities include botanical ingredient authentication, phyto-bioactivities , polyphenol chemistry and free radical chemistry. Botanical reference materials and customer assay development are also part of the portfolio of our services.

135 Beaver Street Waltham, MA 02452Interleukin Genetics, Inc. is a genetics-based personalized health company that develops genetic tests for use in the emerging personalized health market. Our vision is to build a leading personalized health and wellness company. We believe that the science of applied genetics can empower physicians and dentists to improve management of chronic diseases, and empower individuals to personalize their own health. In some diseases, such as osteoarthritis, our tests provide valuable information to assist in drug development. We currently have two primary focus areas to our business. The first is personalized health, which is focused on providing genetic information to physicians, dentists, and in some cases consumers. The second is a research and development effort focused on developing genetic tests linked to a partner's products for marketing and sales into medical and dental channels. Both areas contribute toward our overall mission of providing products that can help individuals improve and maintain their health through preventive measures. We plan to pursue improving personalized healthcare for patients by: processing genetic risk assessment tests in our CLIA-certified lab or in labs of sub licensees for ourselves or for partners; and distributing existing and developing new genetic tests for use in multiple indications, countries and demographics.

198 Tremont St. Boston MA 2116 USAIgan Biosciences develops treatment for IgA nephropathy.

10 Maguire Road Lexington, MA, 02421 United StatesImprivata enhances care delivery by providing fast,secure access to patient information.

26 Parkridge RdJohnson Matthey Pharma Services offers synthetic route design, API and intermediate production, process validation, and manufacturing.

70 Flagship DriveJohnson Matthey Pharma Services offers synthetic route design, API and intermediate production, process validation, and manufacturing.

200 Gilbert Street Mansfield, MA, 02048 United StatesJordi Labs was founded in 1980 to provide the highest quality analytical services and polymer-based HPLC columns in the industry. It is our goal to help our customers overcome their analytical challenges by providing excellent service, products and personal assistance from our highly trained staff. Customers in nearly all industries worldwide are currently using our analytical lab services and GPC column products. Analytical Services: Jordi Labs provides contract analytical services with a special emphasis on chemical identification and liquid chromatography products. The service laboratory at Jordi Labs provides extensive and specialized analytical testing of APIs, polymers, additives and other small molecules. We specialize in Extractable & Leachable studies for Medical Devices, Pharmaceutical packaging and Food Package migration testing. Additional services include method development, preparative HPLC, training seminars, depositions and consulting. Products Today, Jordi services over 1,000 accounts worldwide.

200 Gilbert Street Mansfield, MA, 02048 United StatesJordi Labs was founded in 1980 to provide the highest quality analytical services and polymer-based HPLC columns in the industry. It is our goal to help our customers overcome their analytical challenges by providing excellent service, products and personal assistance from our highly trained staff. Customers in nearly all industries worldwide are currently using our analytical lab services and GPC column products. Analytical Services: Jordi Labs provides contract analytical services with a special emphasis on chemical identification and liquid chromatography products. The service laboratory at Jordi Labs provides extensive and specialized analytical testing of APIs, polymers, additives and other small molecules. We specialize in Extractable & Leachable studies for Medical Devices, Pharmaceutical packaging and Food Package migration testing. Additional services include method development, preparative HPLC, training seminars, depositions and consulting. Products Today, Jordi services over 1,000 accounts worldwide.

One Joslin Place Boston, MA 02215 USAJoslin Flow Cytometry Core of the Joslin Diabetes Center offers cell sorting and flow cytometry services.

Boston, MA United StatesJoslin Flow Cytometry Core of the Joslin Diabetes Center offers cell sorting and flow cytometry services.

One Joslin Place, Boston, MA 02215oslin Diabetes Center is world-renowned for its deep expertise in diabetes treatment and research. Joslin is dedicated to finding a cure for diabetes and ensuring that people with diabetes live long, healthy lives. We develop and disseminate innovative patient therapies and scientific discoveries throughout the world. Joslin is an independent, non-profit institution affiliated with Harvard Medical School, and one of only 11 NIH-designated Diabetes Research Centers in the U.S.

33 Arch Street, Boston, MA 02110, United StatesScientific innovation mixed with pragmatism, our approach is very straightforward. Finding the right solution for our client is our passion. Throughout all of our processes, be it research, development, clinical trial manufacturing or consultancy, our intent is to always provide the best service. High end science-led innovation, GMP capability or basic drug manufacturing, we’ll advise the right route for your project. If you don’t need it, we will tell you. Using a multidisciplinary approach, our streamlined services and focus on scientific rigour and quality ensure your product will progress to clinical trials quickly and safely even for difficult drug development projects. We support a range of pharmaceutical companies from biotechs to leading drug developers. Our people, our processes and our awareness of adaptive technologies drive our business. We welcome challenges because we love finding solutions.

1030 Massachusetts Avenue Cambridge, MA, 02138 United StatesJounce's approach is broad by design – the company's proprietary product engine enables the exploration of multiple mechanisms of action through a broad spectrum of targets.

299 Washington Street Woburn, MA, 01801 United StatesPreclinical drug testing platform integrating Organ-on-Chip (OoC) technologies and computational biology to optimize lead selection and clinical trial design. Javelin Biotech offers the Liver Tissue Chip platform for sale, allowing customers to run studies in their own facilities. In addition, Javelin works with clients to develop new MPS tissue models and protocols for new Contexts of Use. Engage Javelin to develop new human tissue assays for safety, efficacy, and mechanism of action studies. Computational biology and Machine Learning algorithms translate experimental results into predictions that impact IND submissions and clinical trial designs. Tissue Chip models include: liver, gut, and kidney for DMPK, PB/PK, toxicity, drug-drug interaction (DDI), mechanism of action, and other tests. Javelin is able to test small molecules, biologics, and immuno-therapies. Pharmacovigilance. Contact Javelin Biotech to discuss studies that will grow your insight and understanding of your lead candidates and build confidence as you decide which compounds to advance through development, which to further develop, and which to abandon.

299 Washington Street WOBURN, Massachusetts, 01801 United StatesPreclinical drug testing platform integrating Organ-on-Chip (OoC) technologies and computational biology to optimize lead selection and clinical trial design. Javelin Biotech offers the Liver Tissue Chip platform for sale, allowing customers to run studies in their own facilities. In addition, Javelin works with clients to develop new MPS tissue models and protocols for new Contexts of Use. Engage Javelin to develop new human tissue assays for safety, efficacy, and mechanism of action studies. Computational biology and Machine Learning algorithms translate experimental results into predictions that impact IND submissions and clinical trial designs. Tissue Chip models include: liver, gut, and kidney for DMPK, PB/PK, toxicity, drug-drug interaction (DDI), mechanism of action, and other tests. Javelin is able to test small molecules, biologics, and immuno-therapies. Pharmacovigilance. Contact Javelin Biotech to discuss studies that will grow your insight and understanding of your lead candidates and build confidence as you decide which compounds to advance through development, which to further develop, and which to abandon.

500 Main Street Kendall Square Cambridge, MA USAThe David H. Koch Institute for Integrative Cancer Research at MIT focuses on research and offers flow cytometry, transgenics, imaging, histology, microarray, and microscopy services through the Swanson Biotechnology Center.

60 Hickory Dr Waltham, MA, 02451 United StatesWe are a quality-focused biotechnology company dedicated to enhancing the latest therapeutic technologies, including cell therapies, gene editing, immunotechnology, and vaccines through custom and GMP reagents.

60 Hickory Dr Waltham, MA, 02451 United StatesWe are a quality-focused biotechnology company dedicated to enhancing the latest therapeutic technologies, including cell therapies, gene editing, immunotechnology, and vaccines through custom and GMP reagents.

75 Arlington Street Suite 500 Boston, MA, 02116

36 Dartmouth Street, Suite 304Kollodis BioSciences offers a variety of biofunctionalized mussel adhesive proteins for your research and development needs.

Malden, MA United StatesKollodis BioSciences offers a variety of biofunctionalized mussel adhesive proteins for your research and development needs.

Koch Institute at MIT 77 Massachusetts Avenue Cambridge, Building 76-189B, MA 02139,

200 5th Avenue Waltham, MA, 02451 United States

21 Alpha Road, Suite D Chelmsford, MA 01824 USAKrueger Food Laboratories, Inc. (KFL) is an independent food testing and consulting laboratory, incorporated since 1984 in the Commonwealth of Massachusetts. KFL is a full service analytical testing laboratory and is the leader in fruit juice and flavor analysis. Our routine services include nutritional labeling analysis, authenticity evaluation of fruit juice products, flavorings, beverages and sweeteners, microbiology, regulatory support and expert witness assistance.

135 Beaver Street Waltham, MA, 02452 United StatesKala's therapies have unique properties to penetrate mucosal barriers for unprecedented efficacy.

955 Mass. Ave., # 305 Cambridge MA 2139 USAKARD Scientific provides pharmacology, drug development, disease modeling, biomarkers, and histo-immunochemistry.

350 lincoln street Suite 2216 Hingham, MA 02043karmadata is a collection of the world's healthcare data, all standardized, linked, and accessible in one place.

Hingham, MA United Stateskarmadata is a collection of the world's healthcare data, all standardized, linked, and accessible in one place.

29 Newbury Street Suite 301 Boston, MA, 02116 United StatesKibur Medical closes the translational gap with a proprietary, in vivo pathology-driven technology that brings the laboratory to the patient, enabling drug developers to accelerate and make better choices in their development programs to increase clinical success and allowing clinicians to select therapies that improve patient outcomes.

75 Kneeland Street 14th floor Boston, MA, 02111 United StatesKibur Medical closes the translational gap with a proprietary, in vivo pathology-driven technology that brings the laboratory to the patient, enabling drug developers to accelerate and make better choices in their development programs to increase clinical success and allowing clinicians to select therapies that improve patient outcomes.

75 Kneeland Street 14th floor Boston, MA, 02111 United StatesKibur Medical closes the translational gap with a proprietary, in vivo pathology-driven technology that brings the laboratory to the patient, enabling drug developers to accelerate and make better choices in their development programs to increase clinical success and allowing clinicians to select therapies that improve patient outcomes.

210 Broadway. Suite 201 Cambridge, MA, 02139 United StatesUtilizing automation & versatile synthesis, kbDNA provides research laboratories in early-to-late phase discovery with synthetic bioreagents specific to their target objectives.

533 Bolivar Street, 6th floorLouisiana Gene Therapy conducts research in the areas of stem cells, virology, infectious disease, and gene therapy.

# 2, Survey No. 08Lotus Labs offers clinical research services such as regulatory services, clinical trials, quality assurance, and bioanalytical research.

Phoenix Park D106 2 Shaker Road Shirley, MA 01464 LEX Company offers consulting services in chemical R&D area. The company research labs can provide custom synthetic services, including kilo scale, for rare amino acids, peptides, semi-synthetic natural products and bio-conjugates. We accept projects in the natural products chemistry area, focused on the discovery of bio-active compounds in plant extracts and on their synthetic modifications for pharmaceutical purposes. We collaborate with top biological laboratories to discover new antiviral and anticancer compounds.

1035 Cambridge St Ste 16C Cambridge, MA, 02144 United StatesLifeCanvas Technologies is a biotech startup founded by MIT Professor Kwanghun Chung, a pioneer in the field of tissue clearing (see CLARITY, SWITCH, MAP, SHIELD, and eFLASH). From pre-formulated reagents and turn-key devices to full-service sample handling, our pipeline is the world’s only end-to-end solution for processing whole organs from preservation to analysis. Reach out today to speak to one of our expert scientists about how our 3D histology, imaging, & analysis solutions can accelerate your research and expedite new discoveries.

1035 Cambridge Street Suite 9 Cambridge, MA, 02141 United StatesLifeCanvas Technologies is a biotech startup founded by MIT Professor Kwanghun Chung, a pioneer in the field of tissue clearing (see CLARITY, SWITCH, MAP, SHIELD, and eFLASH). From pre-formulated reagents and turn-key devices to full-service sample handling, our pipeline is the world’s only end-to-end solution for processing whole organs from preservation to analysis. Reach out today to speak to one of our expert scientists about how our 3D histology, imaging, & analysis solutions can accelerate your research and expedite new discoveries.

1035 Cambridge Street Suite 9 Cambridge, MA, 02141 United StatesLifeCanvas Technologies is a biotech startup founded by MIT Professor Kwanghun Chung, a pioneer in the field of tissue clearing (see CLARITY, SWITCH, MAP, SHIELD, and eFLASH). From pre-formulated reagents and turn-key devices to full-service sample handling, our pipeline is the world’s only end-to-end solution for processing whole organs from preservation to analysis. Reach out today to speak to one of our expert scientists about how our 3D histology, imaging, & analysis solutions can accelerate your research and expedite new discoveries.

35 South Street Hopkinton, MA, 01748 United StatesLakePharma, now part of Curia, is the leading US-based biologics contract research, development, and manufacturing organization (CRDMO). The company has developed a range of technologies and capabilities in antibody discovery, protein engineering, cell line development, process optimization, and GMP manufacturing. With comprehensive technologies, integrated platforms, and five facilities located in key biopharma hubs on both the East and West Coast, LakePharma enables and supports the discovery and development of the biologics of tomorrow.

50 Prescott Street, Worcester, MA 01605, USLakePharma, now part of Curia, is the leading US-based biologics contract research, development, and manufacturing organization (CRDMO). The company has developed a range of technologies and capabilities in antibody discovery, protein engineering, cell line development, process optimization, and GMP manufacturing. With comprehensive technologies, integrated platforms, and five facilities located in key biopharma hubs on both the East and West Coast, LakePharma enables and supports the discovery and development of the biologics of tomorrow.

722 Main Street Boylston, MA, 01505 United StatesAn independent analytical testing laboratory which has served the metals and materials industry for over forty years and has attracted and retained customers from throughout the world.

800 South Street Suite 100 Waltham, MA, 02453 United StatesLUMICKS is a next-generation life science tools company focused on enabling more efficient research, drug development, bioprocessing, bioproduction quality control, and patient treatment. For the first time ever, our unapparelled solutions can assist research by directly linking structural and ‘omics analysis to functional outcomes at both a molecular and a cellular level. This is achieved by applying and measuring forces around biological interactions, enabling the detailed real-time analysis of underlying biological mechanisms. We have leveraged our deep biophysics expertise to develop differentiated technologies that are designed to drive new and faster innovations. Our products utilize our proprietary dynamic single-molecule (DSM) analysis and cell-binding avidity (CA) analysis technologies.

70 Shawmut Road Canton, MA 02021Lapuck Laboratories, Inc. provides food testing services to various memebers of the food industry including food processors, food retailers and food service establishments. Lapuck Laboratories' microbiologist and chemists use the latest FDA, APHA, AOAC, and FDA/USDA approved ELISA methods in analyzing such foods as meat, poultry , seafood, produce, bakery, and dairy products. We also specialize in microbial limit testing of nutritional supplements using USP methods. Lapuck Laboratories Project Managers work with food industry clients and assist them in establishing a testing program that best suits the client's need for in-house quality control and/or regulatory compliance with the most cost-effective approach.

85 Bolton StreetLigon Discovery discovers and develops innovative human medicines targeting important therapeutic needs.

Cambridge, MA United StatesLigon Discovery discovers and develops innovative human medicines targeting important therapeutic needs.

Boston, MA 02116 USAThe Laboratory for the Identification and Characterization of Unknown Substances (LICHUS) provides high quality chemical testing and consulting services. We use proven analytical chemistry methodologies to determine the chemical structure and composition of samples provided by our clients.

10 Burke Drive Brockton, MA 02301 USALyne specializes in the manufacture of oral liquids, powders, semi-solids, tablets and liquid unit-dose packaging.

165 New Boston Street Woburn, MA 01801 USALC Laboratories manufactures and providers small-molecule reagents.

Woburn, MA United StatesLC Laboratories manufactures and providers small-molecule reagents.

200 River’s Edge Drive, Medford, Massachusetts, 02155 USALabthink International, Inc. is a global enterprise that provides professional quality control solutions for packaging materials and products.

200 Rivers Edge Drive Medford, MA, 02155 United StatesLabthink International, Inc. is a global enterprise that provides professional quality control solutions for packaging materials and products.

1 Broadway 14th Floor Cambridge, Massachusetts, 02142 United StatesLikarda is a cell therapy and delivery R&D company with expertise in cell-based products. We have developed a number of innovations in this area over the years and are moving many in our pipeline to the clinic as therapeutics in addition to growing our platform. Likarda’s foundational technology is based on cell encapsulation and delivery in hydrogels using our patented Core-Shell Spherification(TM) (CSS) system. Unlike technologies that utilize alginate or modify alginate (which is basically a bandaid for a temporary solution), Likarda utilizes readily available and biocompatible hydrogel materials such as hyaluronic acid, PEG, and a number of other chemistries to microencapsulate cells. These hydrogels are already being used and successful in wound healing, cosmetics, as dermal fillers, and in join viscosupplements. This can produce superior biocompatible cell-based treatments by either: (1) Durable: coating the cells in an immunoprotective barrier for injection/transplant for long-term treatments, or; (2) Degradable: injectable cell therapies in a slow-release, degradable formulation enabling localized cell release over time and increased efficacy. CSS if versatile, enabling both durable and degradable versions, and can be applied to several cell therapy indications for pets and humans. Likarda also has expertise in hydrogels in other formats as well. Our team has experience with chemistries of these materials and how to modify them in both microencapsulants and as bulk hydrogels to fit your needs.

22 Laurel St. Leominster, MA , 01453 United StatesLandrau Scientific Innovations LLC is a pre-clinical contract research organization offering a full spectrum of chemistry, manufacturing and control (CMC) services for drug development. Our core competencies include drug formulation and analysis. LSI operates a full state-of-the-art solid dose facility that can support accelerated development of tablet and coated formulations. Our capabilities range from from feasibility studies to production scale batches. We provide comprehensive services in analysis, due diligence, and the design of IP strategies that will enable the launch of programs focused on new drug delivery technologies and drug reformulations.

11 Penobscot Dr Natick, MA, 01760 United StatesLee Herman Consulting offers computational chemistry and cheminformatics consulting and solutions.

One Broadway Cambridge, MA 02142 (USA)Lipomed provides reference standards and pharmaceuticals for the treatment of rare diseases.

1050 Winter Street, Suite 2300 Waltham, MA, 02451 United States

28 Exeter Street, Suite 301Label Independent provides label-free assay development, kinase profiling, and GPCR screening.

Boston, MA United StatesLabel Independent provides label-free assay development, kinase profiling, and GPCR screening.

75 State Street 19th Floor Boston, MA 02109 USAL.E.K. provides industry expertise and consulting services for strategic advice, mergers, shareholder value management, operations, marketing and sales.

37 Birch Street Milford, MA, 01757 United StatesLGC is a global manufacturer and distributor of high-quality certified reference materials, research chemicals (TRC), genomics solutions, proficiency testing, and analytical testing services. We employ our 180 years of scientific heritage, cutting-edge expertise in measurement science and track record of innovation to progress research & development and improve outcomes across pharmaceuticals, diagnostics, food, environment, industry and consumer products. Our products and services stand out, producing to the highest quality, continually adapting to changing regulation, and providing expert support and documentation to help ensure the accuracy of your analytical results. LGC. Science for a safer world. We serve as the UK’s National Measurement Institute for chemical and bioanalytical measurements. Meet our brands: - TRC TRC offers 150,000+ research chemicals, with a large inventory readily available globally. Discover our wide range of bioactive small molecules, stable isotope labelled & controlled substances to advance your research. - AXIO Proficiency Testing AXIO Proficiency Testing is a global provider of proficiency testing schemes. We support over 13,000 laboratories, with over 2,700 proficiency tests, in over 165 countries worldwide, to meet their regulatory and accreditation requirements. - Dr Ehrenstorfer Dr Ehrenstorfer provides a comprehensive range of high-quality reference materials. Over 50% of the portfolio is accredited to ISO 17034, with 14,000+ reference materials available. - LGC Industrial LGC Industrial offers innovative & agile measurement tools for a safe global infrastructure. Combining VHG, ARMI, MBH & Paragon Scientific, we deliver a wide range of petrochemical, metal, mining, powder & physical reference materials. - Mikromol Mikromol offers a portfolio of 7,000+ high-quality accredited pharmaceutical API, impurity & excipient reference standards, >95% ready to ship alongside market leading COAs. We also provide RMs management services & custom manufacturing. - Clinical Diagnostics LGC Clinical Diagnostics develops and manufactures a comprehensive portfolio of catalogue and custom-developed diagnostic quality solutions, biological and reagent component materials for the extended life sciences industry. - LGC Genomics LGC Genomics offers a custom DNA sequencing service. It is comprised of Biosearch Technologies & LGC Axolabs. i) Biosearch Technologies offers GMP and RUO Oligonucleotides, Molecular biology reagents, NGS kits and enzymes, Oligo synthesis reagents and instruments, PCR reagents and instruments, and sample prep reagents and instruments. ii) LGC Axolabs offers a unique services portfolio for the development of nucleic acid therapeutics and nucleic acid-based medicines.

97 South Street, Hopkinton, MA, 01748 USALonza provides advanced cell biology and cell engineering solutions that support customers from discovery to the clinic. We provide primary human cells, specialized media, advanced cell culture and transfection tools, supported by best-in-class quality, regulatory and scientific support. We support customers from basic research through preclinical and process development stages of small molecules, biologics, and cell and gene therapy programs in drug discovery and immuno-oncology. This includes immunogenicity prediction and assessment, manufacturability risk assessment and protein re-engineering.

49 CRAGMORE RD Newton, MASSACHUSETTS, 02464-1008 United StatesService contract organization for cell and tissue biomechanical measurements

49 CRAGMORE RD Newton, MASSACHUSETTS, 02464-1008 United StatesService contract organization for cell and tissue biomechanical measurements

Richard B. Simches Research Center 185 Cambridge Street Boston, MA 02114

185 Cambridge StreetMassachusetts General Hospital Hock Lab focuses on research of transcription factors in blood development and leukemia.

4 H Constitution Way Woburn, MA 01801 USAMBL International provides microarrays, gels, cell cycle indicators, antibodies.

9 Cambridge Center, Rm 325, Cambridge, MA - 02142Whitehead Institute Genome Technology Core provides microarray, expression analysis, screening and sequencing services.

9 Cambridge Center, room 351 Cambridge, MA 02142Recent research in cancer biology, aging, microbial pathogenesis, and many other areas has revealed a key role for small molecule and lipid metabolites. The Metabolite Profiling Core Facility was established in 2013 to support studies in this rapidly developing field. Due to the extreme chemical diversity of small molecule and lipid metabolites – which greatly exceeds that of proteins and nucleic acids – the facility operates on a collaborative model in which experimental design, sample preparation, data collection, and data analysis are tailored to each study. We serve the Whitehead as well as the larger MIT community and external collaborators. The facility is operated by Elizaveta (Lisa) Freinkman, Ph.D., who assists researchers with experimental design and sample preparation strategies, performs LC/MS experiments, and analyzes data, in addition to developing new analytical techniques for metabolites that are not adequately measured by our existing methods. Also, a full-time technician, Tenzin Kunchok, performs routine instrument maintenance and sample preparation, and also assists with facility operations. The faculty advisor for the facility is Prof. David M. Sabatini, M.D., Ph.D.

9 Cambridge Center Cambridge, MA, 02142 United StatesRecent research in cancer biology, aging, microbial pathogenesis, and many other areas has revealed a key role for small molecule and lipid metabolites. The Metabolite Profiling Core Facility was established in 2013 to support studies in this rapidly developing field. Due to the extreme chemical diversity of small molecule and lipid metabolites – which greatly exceeds that of proteins and nucleic acids – the facility operates on a collaborative model in which experimental design, sample preparation, data collection, and data analysis are tailored to each study. We serve the Whitehead as well as the larger MIT community and external collaborators. The facility is operated by Elizaveta (Lisa) Freinkman, Ph.D., who assists researchers with experimental design and sample preparation strategies, performs LC/MS experiments, and analyzes data, in addition to developing new analytical techniques for metabolites that are not adequately measured by our existing methods. Also, a full-time technician, Tenzin Kunchok, performs routine instrument maintenance and sample preparation, and also assists with facility operations. The faculty advisor for the facility is Prof. David M. Sabatini, M.D., Ph.D.

S-402, South Block,MakroCare is a clinical research organization and offers late phase studies, quality assurance, regulatory affairs, clinical monitoring and data management.

800 Technology Center Drive, Stoughton, MA, 02072 USAMedical Specialties Distributors (MSD) provides site infusion, total enterprise solutions, equipment rental, and national distribution.

Room 447 Whitehead Institute 9 Cambridge Center, Cambridge, MassachusettsThe W.M. Keck Biological Imaging Facility is located in room 447 of the Whitehead Institute at Nine Cambridge Center, Cambridge Massachusetts. The facility is managed by microscopist Nicki Watson and directed by Whitehead member Iain Cheeseman. The facility provides scientists with the equipment and training necessary to generate and interpret microscopic images. In addition to serving Whitehead and MIT, the facility is open to the local research community.

9 Cambridge Center Cambridge, MA, 02142 United StatesThe W.M. Keck Biological Imaging Facility is located in room 447 of the Whitehead Institute at Nine Cambridge Center, Cambridge Massachusetts. The facility is managed by microscopist Nicki Watson and directed by Whitehead member Iain Cheeseman. The facility provides scientists with the equipment and training necessary to generate and interpret microscopic images. In addition to serving Whitehead and MIT, the facility is open to the local research community.

210 Broadway Cambridge, MA, 02139 United StatesMtoZ Biolabs is an international contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.

155 Federal Street, Suite 700 Boston, MA, 02110 United StatesMtoZ Biolabs is an international contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.

One Mifflin Place, Suite 400 Cambridge, MA, 02138 United StatesMaratech NMR Solutions is a contract research organization that partners with Biotech and Pharmaceutical companies to advance drug discovery programs through the use of Nuclear Magnetic Resonance, NMR.

66 taylor rd acton, MA, 01720 United StatesMaratech NMR Solutions is a contract research organization that partners with Biotech and Pharmaceutical companies to advance drug discovery programs through the use of Nuclear Magnetic Resonance, NMR.

100 Barber Ave.Microbac Laboratories, Inc. is a full-service contract laboratory (cGMP and GLP) offering: Microbiology, Analytical Chemistry,and Virology testing. Other tests: Stability, Environmental Monitoring, and Elemental Analysis. Industries serviced: Pharmaceutical, Biotech, Generics, Cosmetics, and OTC. Microbac will work as the contracted laboratory supporting laboratory testing services in preparation for filing the IND - NDA, BLA and ANDA Submissions.

17 Briden Street Worcester, MA, 01605 United StatesMicrogradient Fluidics LLC develops custom microfluidic and spectroscopic instrumentation for quantifying protein stability, binding and kinetics. Among the services we offer are time-resolved fluorescence, time-resolved anisotropy, fluorescence correlation spectroscopy which are coupled to automated microfluidic and microplate systems. We also specialize in custom data analysis software for global analysis of kinetics, binding and stability.

45 Prospect St Cambridge, MA, 02139 United StatesMD Biosciences Neuro is a preclinical and translational contract research organization (CRO) offering services for drug development in the field of neurology and pain research. We understand that finding a trust-worthy preclinical partner is a top priority for drug developers and believe that you should have confidence in the partner you choose. That's why we are dedicated to providing each client valued expertise and advice, experience for flawless execution, and flexibility to meet the needs of rapidly changing requirements. With a presence in the innovation hubs of Cambridge, Massachusetts and with state of the art laboratories in Israel, our team is dedicated to building collaborative programs and creating lasting partnerships in the biotechnology community. Newly built in 2021, our 20,000 square feet CNS research facility was purpose-built for translational CNS research and boasts dedicated wings for rodent research, translational pig research, and in vitro biomarker research. Each wing contains custom housing facilities along with expertly designed surgical suites, treatment rooms, and behavioral suites that minimize environmental stress factors that can impact CNS and pain studies.

200 Homer Avenue Ashland MA 01721 USAMatTek provides tissue engineering, tissue equivalents, safety assessment, and target organ research.

200 Homer Ave Ashland, MA, 01721 United StatesMatTek provides tissue engineering, tissue equivalents, safety assessment, and target organ research.

Ashland, MA United StatesMatTek provides tissue engineering, tissue equivalents, safety assessment, and target organ research.

1354 Hancock StreetMouse Specifics provides ECG, imaging, and heart perfusion systems for rats mice, and guinea pigs.

Quincy, MA United StatesMouse Specifics provides ECG, imaging, and heart perfusion systems for rats mice, and guinea pigs.

7 Lenora Street Worcester, MA, 01607 United StatesSince 1985, MHS has been offering a comprehensive range of histological techniques to fit all individual needs. Whether it's an occasional H&E stained slide or multiple daily specimens, no request is ever considered too small or too large. All histologists at MHS are either ASCP certified or eligible and offer decades of combined experience in all phases of histopathological theory, practice and technique. Many of the slides produced at MHS have been reproduced in numerous publications and texts seen throughout the world. We follow all GLP (Good Laboratory Practice) guidelines as outlined by the FDA. Our clinical lab is a fully equipped diagnostic and research facility which is staffed by well-trained professionals and headed by a licensed medical technician. We are certified by the USDA-APHIS for foreign animal disease testing in specific areas. In addition to all specie diagnostic testing, we have participated in various research contracts including projects analyzing mouse, rat, reptile, avian, non-human primate and amphibian blood/serum samples. With many years of experience, we have the expertise and experience to investigate, create and implement new ideas and/or procedures.

7 Lenora Street Worcester, MA, 01607 United StatesSince 1985, MHS has been offering a comprehensive range of histological techniques to fit all individual needs. Whether it's an occasional H&E stained slide or multiple daily specimens, no request is ever considered too small or too large. All histologists at MHS are either ASCP certified or eligible and offer decades of combined experience in all phases of histopathological theory, practice and technique. Many of the slides produced at MHS have been reproduced in numerous publications and texts seen throughout the world. We follow all GLP (Good Laboratory Practice) guidelines as outlined by the FDA. Our clinical lab is a fully equipped diagnostic and research facility which is staffed by well-trained professionals and headed by a licensed medical technician. We are certified by the USDA-APHIS for foreign animal disease testing in specific areas. In addition to all specie diagnostic testing, we have participated in various research contracts including projects analyzing mouse, rat, reptile, avian, non-human primate and amphibian blood/serum samples. With many years of experience, we have the expertise and experience to investigate, create and implement new ideas and/or procedures.

7 Lenora Street United States Worcester, Massachusetts, 01607 United StatesSince 1985, MHS has been offering a comprehensive range of histological techniques to fit all individual needs. Whether it's an occasional H&E stained slide or multiple daily specimens, no request is ever considered too small or too large. All histologists at MHS are either ASCP certified or eligible and offer decades of combined experience in all phases of histopathological theory, practice and technique. Many of the slides produced at MHS have been reproduced in numerous publications and texts seen throughout the world. We follow all GLP (Good Laboratory Practice) guidelines as outlined by the FDA. Our clinical lab is a fully equipped diagnostic and research facility which is staffed by well-trained professionals and headed by a licensed medical technician. We are certified by the USDA-APHIS for foreign animal disease testing in specific areas. In addition to all specie diagnostic testing, we have participated in various research contracts including projects analyzing mouse, rat, reptile, avian, non-human primate and amphibian blood/serum samples. With many years of experience, we have the expertise and experience to investigate, create and implement new ideas and/or procedures.

16 Tech Circle Suite 204 Natick, MA, 01760 United StatesMB Biosciences is a life science company specializing in cell–based Products and Services both in vitro and in vivo; We provide Liver-specific and Hepatocytes-based Products and Services: we provide human, rat and mouse hepatocytes in suspension; ready-to-use hepatocytes in multiple plate format; 3D hepatocytes spheroid and liver organoid ; hepatocytes culture medium which maintain primary hepatocytes alive up to 4 weeks in vitro. We offer perfusion and hepatocytes isolation services from WT Mouse and Rat, transgenic and various disease mouse models; We also provide various Hepatic assays services; We provide genotoxicity and mutagenicity analyses -AMES, Genomic deletion, micronucleus assays with best price and quickest turn around time; We offer Permeability-based products and services (intestinal, airway, BBB, T84, Caco2, MDR1-MDCK, Calu3); Drug-drug interaction services (CYP and UGP induction and inhibition); We offer In vivo PK and PD study; In vivo xenografts tumor model services and Biomarker discovery. MB Biosciences is committed to providing the highest quality products and services with a shortest turnaround time.

55 Fruit StreetMassachusetts General Hospital Luster Lab offers transgenic mice and mouse disease models for asthma, atopic dermatitis, arthritis, lupus, transplant rejection, atheroslerosis, malaria, influenza, HIV and toxoplasmosis.

185 Alewife Brook Parkway, #410 Cambridge, MA 02138 U.S.A.Mind the Byte is a bioinformatics company that develops and provides software for computational drug discovery using Big Data and Machine Learning (AI) approaches. We work with partners on a consultancy basis or offer an easy to use Software as a Service (SaaS) package to allow clients to apply the High-performance computing platform on a flexible pay-per-use basis without investment in hardware or software licenses. Mind the Byte has developed a versatile set of applications using cloud computing which lowers the entry barrier to the technology, e.g. i) virtual profiling methods to facilitate the identification of targets and mechanisms of action of phenotypic screening hits or natural products with reported activity ii) virtual screening methods to identify compounds acting on a specific target by mining internal or commercial compound libraries, to expand hit or lead series and to conduct repurposing of known drugs. iii) MtBDock - a fully integrated docking protocol reducing the amount of false positives by incorporation of all prosthetic groups and conformational minimization iv) SmartDock - an experimentally validated docking protocol with further improved performance based on machine learning of PDB target-ligand interactions Mind the Byte is an Amazon Web Services technology partner - a seal of quality that has only been awarded to five companies in this sector – to ensure security and reliability. The company was founded in 2011 by Alfons Nonell-Canals, a specialist in computer-aided drug design and in large-scale chemical and biological analyses, and has since expanded with an experienced staff.

100 Bridge StreetMedical Isotopes offers custom synthesis services in addition to providing stable isotope chemicals and metal isotopes.

55 Fruit Street, Boston, MA 02114

122 Charlton StreetMoritex provides semiconductor manufacturing, imaging systems, electronic equipment, information technology, and laboratory automation.

55 Fruit Street Boston, MA, 02114 United StatesMassachusetts General Hospital, in addition to providing health care, conducts translational and clinical research.

Boston, MA United StatesMassachusetts General Hospital Imaging provides imaging services.

675 West Kendall Street Cambridge, MA, 02142 United StatesMomenta is a leader in the analysis, characterization, and design of complex pharmaceutical products.

243 Charles Street Boston, MA 02114Our Mission Massachusetts Eye and Ear is a specialty hospital dedicated to excellence in the care of disorders that affect the eye, ear, nose, throat, and adjacent regions of the head and neck. Mass. Eye and Ear provides primary care and serves as a referral center for outpatient and inpatient medical and surgical care. In conjunction with Harvard Medical School, Mass. Eye and Ear is committed to the education of future health care professionals, as well as the education of the public concerning the prevention, diagnosis, and treatment of the diseases in its specialties and concerning the rehabilitation of patients handicapped by these diseases. In order to provide the highest quality of contemporary care and even better care in the future, Mass. Eye and Ear conducts laboratory and clinical research in its areas of specialty. Mass. Eye and Ear recognizes its obligation to serve as a source of excellence in patient care, teaching, and research in Massachusetts, the United States, and the world. Our Vision Massachusetts Eye and Ear will be the preeminent world-wide source of advances and leaders in preserving and restoring vision, hearing, balance and voice, as well as in curing disorders of the head and neck. We will achieve this vision through our mission: Providing exceptional clinical care Conducting cutting-edge translational and bench research Teaching tomorrow’s leaders and today’s medical community Our Values Quality Patient Care. In every decision we make, we will ensure that our primary focus is on the delivery of the highest quality of patient care possible and that we will continue to work to improve what is possible for patients everywhere. Service Excellence. We want to make access to the care we provide easier for a wider range of patients, expanding our range by forging new relationships and alliances. We want our patients, physicians, researchers and employees to have the best experience possible in a healthcare environment, respecting the unique needs and goals of all.

160 New Boston Street Woburn, MA, 01801Millenium Research Laboratory provides bioanalytical, stability, chemistry, and formulation services.

55 Fruit StreetMassachusetts General Hospital Molecular Profiling Laboratory provides bioinformatics, nucleic acid characterization, DNA microarray, PCR, and RNAi knockdown services.

Boston, MA United StatesMassachusetts General Hospital Molecular Profiling Laboratory provides bioinformatics, nucleic acid characterization, DNA microarray, PCR, and RNAi knockdown services.

104 Gold Street Agawam MA 01001-3807MicroTest Laboratories provides provides analytical chemistry testing, medical device testing, pharmaceutical testing, contract manufacturing, and virology/biosafety services.

Agawam, MA United StatesMicroTest Laboratories provides provides analytical chemistry testing, medical device testing, pharmaceutical testing, contract manufacturing, and virology/biosafety services.

84 October Hill Road Holliston, MA 01746 USAMaia Scientific develops instrumentation and software for high information content screening in addition to providing expertise in high throughput assay development.

55 Fruit Street Boston, MA 02114Welcome to the Research Institute Research at Mass General is conducted with the support and guidance of the Mass General Research Institute. Our Mission The Research Institute is built on a culture of excellence, compassion and groundbreaking scientific achievement.

55 Fruit Street Boston, , MA , 02114 United StatesWelcome to the Research Institute Research at Mass General is conducted with the support and guidance of the Mass General Research Institute. Our Mission The Research Institute is built on a culture of excellence, compassion and groundbreaking scientific achievement.

Boston, MA United StatesMassachusetts General Hospital Genetic Animal Models Core offers IBD research and murine models of IBD.

Matrix Science Inc 225 Franklin Street 26th Floor Boston, MA 02110 USAYou are welcome to submit searches to this free Mascot Server. Searches of MS/MS data are limited to 1200 spectra and some functions, such as no enzyme searches, are unavailable. Automated searching of batches of files is not permitted. If you want to automate search submission, perform large searches, search additional sequence databases, or customise the modifications, quantitation methods, etc., you’ll need to license your own, in-house copy of Mascot Server.

Boston, MA United StatesYou are welcome to submit searches to this free Mascot Server. Searches of MS/MS data are limited to 1200 spectra and some functions, such as no enzyme searches, are unavailable. Automated searching of batches of files is not permitted. If you want to automate search submission, perform large searches, search additional sequence databases, or customise the modifications, quantitation methods, etc., you’ll need to license your own, in-house copy of Mascot Server.

1 Orange Street Unit 4 Newburyport, MA , 01950 United States

99 Hayden Ave., Suite 210 Lexington, MA 02421 USAMedChem Partners specializes in medicinal chemistry and offers custom synthesis, strategic planning, and hit/lead optimization services.

Lexington, MA United StatesMedChem Partners specializes in medicinal chemistry and offers custom synthesis, strategic planning, and hit/lead optimization services.

Room 323 Whitehead Institute for Biomedical Research Nine Cambridge Center Cambridge MA 02142The Whitehead Proteomics Core Facility provides proteomics resources to Whitehead and MIT community as well as other institutions. We utilize high resolution mass spectrometry and liquid chromatography for protein identification, comparative proteomics and quantitative proteomics as well as the identification of post-translational modifications. The facility is run by Eric Spooner and is located in Rm327 of the Whitehead Institute at Nine Cambridge Center, Cambridge, Massachusetts. (617-324-1805) Our technology uses "bottom-up" proteomics technology where proteins are digested with trypsin and the resulting peptides are chromatographicly separated and analyzed by tandem mass spectrometry on an Orbitrap Elite mass spectrometer. Protein identification and quantitative information are obtained through using database search engines and species specific databases. The results are presented in a spreadsheet format using commercially available viewers. The facility performs both quantitative proteomics analysis, post translational modification identification and simple protein identifications. We work with both gel-based and solution-based samples, perform two dimensional chromatographic separations, and stable isotope labeling methods including SILAC, TMT and iTRAQ.

Cambridge Center Cambridge, MA, 02142 United StatesThe Whitehead Proteomics Core Facility provides proteomics resources to Whitehead and MIT community as well as other institutions. We utilize high resolution mass spectrometry and liquid chromatography for protein identification, comparative proteomics and quantitative proteomics as well as the identification of post-translational modifications. The facility is run by Eric Spooner and is located in Rm327 of the Whitehead Institute at Nine Cambridge Center, Cambridge, Massachusetts. (617-324-1805) Our technology uses "bottom-up" proteomics technology where proteins are digested with trypsin and the resulting peptides are chromatographicly separated and analyzed by tandem mass spectrometry on an Orbitrap Elite mass spectrometer. Protein identification and quantitative information are obtained through using database search engines and species specific databases. The results are presented in a spreadsheet format using commercially available viewers. The facility performs both quantitative proteomics analysis, post translational modification identification and simple protein identifications. We work with both gel-based and solution-based samples, perform two dimensional chromatographic separations, and stable isotope labeling methods including SILAC, TMT and iTRAQ.

One Kendall Square, Suite B7201 Cambridge, MA 02139Systems Biology at Merrimack integrates the fields of biology, computing and engineering

Cambridge, MA United StatesSystems Biology at Merrimack integrates the fields of biology, computing and engineering

2 Tech Drive Suite 201 Andover, MA, 01810 United StatesAt MKS, our technology enables the future and our innovations have helped shape the direction of industries. Our people are experienced and creative problem solvers who collaborate with customers to find solutions. MKS Instruments, Inc is the worldwide leader in technology solutions for the markets we serve. We make the instruments, subsystems and process control solutions that enable our customers to measure, control, power, monitor and analyze the critical parameters of the advanced processes that they manage.

187 Billerica Road Chelmsford, MA 01824 USAMicroVision Labs providers microscopy consulting services.

25 First Street Cambridge, MA 02141 USAManta Product Development provides full range product development services.

460 Walk Hill Street Boston, MA 02126 USAUniversity of Massachusetts Medical School is a non-profit academic institution that has 40+ Research Core Facilities open to outside academic and industry customers.

University of Massachusetts Medical School 55 Lake Avenue N Worcester, MA, 01655 United StatesUniversity of Massachusetts Medical School is a non-profit academic institution that has 40+ Research Core Facilities open to outside academic and industry customers.

19 Foster Street Worcester, MA 01608-1715Brilliance Begins at Massachusetts College of Pharmacy and Health Sciences Massachusetts College of Pharmacy and Health Sciences (MCPHS University) has a legacy built on the pursuit of excellence in healthcare education. We take pride in our history, but are motivated by a curiosity about the future. We commit to training professionals for the future of the exciting, ever-expanding healthcare industry and helping them achieve their career goals. Our students, alumni, and faculty have impacted countless disciplines across the healthcare world and beyond through their proactive efforts.

179 Longwood Avenue Boston, MA 02115-5896Brilliance Begins at Massachusetts College of Pharmacy and Health Sciences Massachusetts College of Pharmacy and Health Sciences (MCPHS University) has a legacy built on the pursuit of excellence in healthcare education. We take pride in our history, but are motivated by a curiosity about the future. We commit to training professionals for the future of the exciting, ever-expanding healthcare industry and helping them achieve their career goals. Our students, alumni, and faculty have impacted countless disciplines across the healthcare world and beyond through their proactive efforts.

179 Longwood Avenue Boston, , MA , 02115-5896 United StatesBrilliance Begins at Massachusetts College of Pharmacy and Health Sciences Massachusetts College of Pharmacy and Health Sciences (MCPHS University) has a legacy built on the pursuit of excellence in healthcare education. We take pride in our history, but are motivated by a curiosity about the future. We commit to training professionals for the future of the exciting, ever-expanding healthcare industry and helping them achieve their career goals. Our students, alumni, and faculty have impacted countless disciplines across the healthcare world and beyond through their proactive efforts.

518 Pleasant Street Northampton, MA , 01060 United StatesMolmeX Scientific, Inc. is a distributor of specialized scientific instrumentation with a high level of expertise and long history in the development of commercial Small Angle X-ray Scattering (SAXS). Our goal is simply to offer the best customer-specific solutions, whether complete systems, or components like source, optics, slits and detectors. Molmex provides installation and service for its product line and an appropriate level of customization so customers can meet their experimental challenges. Under the SAXSLAB label, Molmex manufactures its own Ultra Small Angle Scattering (USAXS) instruments.

114 16th Street Room 1239 Charlestown, Massachusetts 02129The Facility The NIH BMRC is located within the newly renovated state-of-the-art 80,000 sq. ft. research facility in Building 114 at MGH East in Charlestown, adjacent to the MGH's major research facility in Building 149 (1 million sq. ft.). Other functions on the first floor that are accessible by BMRC are a conference room for 400 people that can be partitioned into 3 smaller units (equipped with full spectrum of video and conference amenities), 3 meeting rooms, a kitchen, and a fully equipped animal facility. The building also houses Center for Aging, Genetics and Neurodegeneration; Pediatric Gastroenterology and Nutrition; Mucosal Immunology; Pediatric Surgery; and Cardiovascular Research. The BMRC occupies fully-equipped 5,000 sq. ft. space on the first floor, and an additional space of 2,000 sq. ft immediately above on the second floor. Office space includes principal investigator offices, administrative staff section, computer facility, and fellows' offices. Laboratory space is organized into four sections: (1) microsystems technology laboratory consisting of an 800 sq. ft. Class 1000 cleanroom with a complete set of MEMS equipment, 100 sq. ft. gowning area (Class 10,000), 400 sq. ft. soft lithography area, and 100 sq. ft. service chase; (2) tissue culture facility; (3) wet lab space including chemical fume hoods; (4) microscopy facility. An additional 6,600 sq. ft. of space in Building 149 is currently being renovated to provide a collaborative space to be shared between the BMRC and the MGH Cancer Center.

114 16th Street Room 1239 Charlestown, Massachusetts, 02129 United StatesThe Facility The NIH BMRC is located within the newly renovated state-of-the-art 80,000 sq. ft. research facility in Building 114 at MGH East in Charlestown, adjacent to the MGH's major research facility in Building 149 (1 million sq. ft.). Other functions on the first floor that are accessible by BMRC are a conference room for 400 people that can be partitioned into 3 smaller units (equipped with full spectrum of video and conference amenities), 3 meeting rooms, a kitchen, and a fully equipped animal facility. The building also houses Center for Aging, Genetics and Neurodegeneration; Pediatric Gastroenterology and Nutrition; Mucosal Immunology; Pediatric Surgery; and Cardiovascular Research. The BMRC occupies fully-equipped 5,000 sq. ft. space on the first floor, and an additional space of 2,000 sq. ft immediately above on the second floor. Office space includes principal investigator offices, administrative staff section, computer facility, and fellows' offices. Laboratory space is organized into four sections: (1) microsystems technology laboratory consisting of an 800 sq. ft. Class 1000 cleanroom with a complete set of MEMS equipment, 100 sq. ft. gowning area (Class 10,000), 400 sq. ft. soft lithography area, and 100 sq. ft. service chase; (2) tissue culture facility; (3) wet lab space including chemical fume hoods; (4) microscopy facility. An additional 6,600 sq. ft. of space in Building 149 is currently being renovated to provide a collaborative space to be shared between the BMRC and the MGH Cancer Center.

27 Lomar Park Pepperell, MA, 01463 United StatesMasy’s biorepository offers secure cGMP storage at precisely-controlled conditions. Masy's continuously-monitored biorepository facility securely stores clinical study samples, vaccines, drug compounds, production stock, medical devices, and other biologic products under precisely-controlled temperature and humidity requirements, from controlled room storage through cryogenic freezing, ensuring the integrity of these valuable materials. Off-site cGMP biorepository storage allows you to free up your valuable laboratory and production space for new projects. Let our experienced team of biorepository professionals manage your materials, and remove the burden of inventory oversight and chamber monitoring and maintenance. Masy BioServices can also perform stability testing at all standard ICH setpoints, execute custom stability testing protocols, and perform accelerated aging studies, verifying the useful life of your products with confidence.

10 Lomar Park Pepperell, MA, 01463 United StatesMasy’s biorepository offers secure cGMP storage at precisely-controlled conditions. Masy's continuously-monitored biorepository facility securely stores clinical study samples, vaccines, drug compounds, production stock, medical devices, and other biologic products under precisely-controlled temperature and humidity requirements, from controlled room storage through cryogenic freezing, ensuring the integrity of these valuable materials. Off-site cGMP biorepository storage allows you to free up your valuable laboratory and production space for new projects. Let our experienced team of biorepository professionals manage your materials, and remove the burden of inventory oversight and chamber monitoring and maintenance. Masy BioServices can also perform stability testing at all standard ICH setpoints, execute custom stability testing protocols, and perform accelerated aging studies, verifying the useful life of your products with confidence.

38 Sidney Street, Suite 100, Cambridge , MA , 02139 United States

116 Will Drive Canton, MA, 02021 United StatesBorn in the hotbed of life science innovation, Marvelgent is dedicated to distribute innovative, high quality, cost-effective reagents to academia, and pharmaceutical and diagnostic industries. We work closely with our customers to provide comprehensive solutions to accelerate their research. Marvelgent chooses the best suppliers of quality, reliability and price. We partner with our suppliers to provide detailed product information, responsive customer supports, and reliably delivery. This is our commitment to our customers' success. It ensures our customers use the right products to save their precious time and money in their research and product development.

50 College Street South Hadley, Massachusetts 01075In 1837, Mary Lyon did the unthinkable. She founded the Mount Holyoke Female Seminary, which later became Mount Holyoke College—the first of the Seven Sisters. Radical moves for a woman wearing a bonnet. In doing so, she forever changed the landscape of higher education—not just for women in South Hadley, Massachusetts, but for women around the world. She built a place where women could develop their intellects, hone the power of their voices, and cultivate courage. These days, change is all around us, happening at a pace too fast to measure. And while Mary Lyon couldn’t have foreseen a digitally connected world, she did understand that a woman would need to be agile, creative, and brave to live the life she wanted. Her vision still drives Mount Holyoke. Mary Lyon once issued a challenge to the women who would follow her: “Go forward, attempt great things, accomplish great things.” She did. You will.

50 College Street South Hadley, , Massachusetts , 01075 United StatesIn 1837, Mary Lyon did the unthinkable. She founded the Mount Holyoke Female Seminary, which later became Mount Holyoke College—the first of the Seven Sisters. Radical moves for a woman wearing a bonnet. In doing so, she forever changed the landscape of higher education—not just for women in South Hadley, Massachusetts, but for women around the world. She built a place where women could develop their intellects, hone the power of their voices, and cultivate courage. These days, change is all around us, happening at a pace too fast to measure. And while Mary Lyon couldn’t have foreseen a digitally connected world, she did understand that a woman would need to be agile, creative, and brave to live the life she wanted. Her vision still drives Mount Holyoke. Mary Lyon once issued a challenge to the women who would follow her: “Go forward, attempt great things, accomplish great things.” She did. You will.

Nine Cambridge Center Cambridge, MA 02142The core provides consultation and collaboration, training and education, and software in the areas of bioinformatics and graphics.

9 Cambridge Center Cambridge, MA, 02142 United StatesThe core provides consultation and collaboration, training and education, and software in the areas of bioinformatics and graphics.

840 Memorial Drive Cambridge, MA, 02139 United StatesMersana engineers novel drug conjugates that maximize the potential of new and established therapeutic classes.

462 Washington St P.O. Box 2151 Woburn , MA, 01888 United StatesMedChem Imaging, Inc. (MCI) is a contract research organization that specializes in the chemistry of non-radioactive and radioactive compounds for molecular imaging. Our team helps design radiotracers which provide information about target abundance, occupancy, dose response, as well as the time course of tumor uptake or brain penetration. MCI can also provide molecules radiolabeled with 3H, 11C, 18F, radioiodines or radiometals.

462 Washington St P.O. Box 2151 Woburn , MA, 01888 United StatesMedChem Imaging, Inc. (MCI) is a contract research organization that specializes in the chemistry of non-radioactive and radioactive compounds for molecular imaging. Our team helps design radiotracers which provide information about target abundance, occupancy, dose response, as well as the time course of tumor uptake or brain penetration. MCI can also provide molecules radiolabeled with 3H, 11C, 18F, radioiodines or radiometals.

33 Arch St. Floor 15 Boston, MA, 02110 United StatesMedasource is a national healthcare and life sciences professional services organization. We support the Pharmaceutical, Biotechnology, and Medical Device industries by providing medical, scientific, and analytical expertise and consulting services. Our robust consultant network and active sourcing model is built to support critical functions across R&D, Medical Affairs, and Regulatory.

451 D st STE 707 Boston, MA, 02210 United StatesRapid manufacturer of peptides

77 Warren St Building 3 Brighton, MA 02135 USAProMedica Clinical Research Center (CRC) specializes in phase I-IIa clinical research.

33 Nagog Park Acton, MA, 01720 United StatesAt Microbiology Research Associates Inc. (MRA), our goal is to provide our customers with the highest level of quality microbiological testing service as possible. We know that the quality of our work builds trust and we strive to meet the highest standards of quality to meet and exceed industry and regulatory demands. MRA, an Analytical Lab Group portfolio company, is an industry leader and dedicated to providing personalized microbiology consulting, research and testing services to the pharmaceutical, cosmetic, medical device, biotechnology and health care industries. MRA offers same day testing and continues to be the leader in on-site environmental monitoring of hospital compounding pharmacies in New England. MRA also has a state of the art ISO 5 cleanroom with isolator to meet the needs of all our customers. MRA is an FDA (No# 1000148174) and DEA (No# RM0490932) registered laboratory. For inquiries please contact: Kelly Hagen Director of Business Development 203.685.7919 kelly@mra-bact.com Microbiology Research Associates, Inc. 33 Nagog Park Acton, MA 01720

33 Nagog Park Acton, MA, 01720 United StatesAt Microbiology Research Associates Inc. (MRA), our goal is to provide our customers with the highest level of quality microbiological testing service as possible. We know that the quality of our work builds trust and we strive to meet the highest standards of quality to meet and exceed industry and regulatory demands. MRA, an Analytical Lab Group portfolio company, is an industry leader and dedicated to providing personalized microbiology consulting, research and testing services to the pharmaceutical, cosmetic, medical device, biotechnology and health care industries. MRA offers same day testing and continues to be the leader in on-site environmental monitoring of hospital compounding pharmacies in New England. MRA also has a state of the art ISO 5 cleanroom with isolator to meet the needs of all our customers. MRA is an FDA (No# 1000148174) and DEA (No# RM0490932) registered laboratory. For inquiries please contact: Kelly Hagen Director of Business Development 203.685.7919 kelly@mra-bact.com Microbiology Research Associates, Inc. 33 Nagog Park Acton, MA 01720

One Davol Square Suite 200MicroTissues Inc. is a privately held company advancing technologies and applications of 3D cell culture. The company’s products stand above the rest because they are designed to create more natural and more reliable 3D cell culture environments based on cell-to-cell interactions in convenient and consistent formats that generate high content information. The company’s lead line of products, the 3D Petri Dish®, is serving the needs of researchers in a wide range of areas including cancer research, stem cell biology, toxicity testing, developmental biology, drug discovery, regenerative medicine and tissue engineering. In addition to products for basic research, MicroTissues Inc. is using its platform technology to pursue applications in drug discovery and cell therapy.

9 Galen Street Watertown MA 2472 USANew England Research Institutes provides regulatory affairs, clinical monitoring, quality control, biostatistics, and data infrastructure.

22 Westminster Street Somerville MA 02144-1630 USANeuromorphometrics offers anatomical measurements of the brain with MRI for research, drug trials, and clinical medicine.

424 Beacon Street Boston, MA 02115The New England College of Optometry (NECO) prepares the next generation of eye care providers, educators, and innovators through a rigorous curriculum and extensive clinical experiences. NECO graduates compassionate and skilled optometrists prepared to practice in diverse settings. Located in the heart of Boston, the College is a small, independent graduate institution that currently enrolls students from 34 states and 8 countries. At New College of Optometry, we educate students for careers in eye care delivery, research, and education. We challenge students to think creatively about vision and sight and to contribute to the future of the field. In doing so, we provide quality optometric care to more than 150,000 individuals annually and serve the community through a network of health care organizations and access to vision screenings.

424 Beacon Street Boston, MA, 02115 United StatesThe New England College of Optometry (NECO) prepares the next generation of eye care providers, educators, and innovators through a rigorous curriculum and extensive clinical experiences. NECO graduates compassionate and skilled optometrists prepared to practice in diverse settings. Located in the heart of Boston, the College is a small, independent graduate institution that currently enrolls students from 34 states and 8 countries. At New College of Optometry, we educate students for careers in eye care delivery, research, and education. We challenge students to think creatively about vision and sight and to contribute to the future of the field. In doing so, we provide quality optometric care to more than 150,000 individuals annually and serve the community through a network of health care organizations and access to vision screenings.

Binney Street Cambridge, MA, 02139 United StatesNinePoint Medical brings together experts in medical device development, imaging, optical technology, engineering, and medicine.

52 Dragon CT STE 3B Woburn, MA, 01801 United StatesNovaBioAssays LLC is a Greater Boston-based contract research organization (CRO) specialized in providing innovative mass spectrometric (MS) solutions to facilitate drug discovery and development. We offer a full suite of mass spectrometry services for quantitative and qualitative analysis of proteins and small molecules.

Suite#400 Woburn, MA, 01801 United StatesNovatein Biosciences is a rapidly growing biological reagents company specializing in the production and supply of immunoassay kits, reagents and proteins to researchers worldwide. We supply more than 10,000 different types of proteins and antibodies, and have one of the richest supplies of validated ELISA kits. In addition, we function as a contract research organization (CRO) assisting our clients in protein/ antibody production and immunoassay development and setup. As a manufacturer of reliable ELISA kits, our scientists are experts in performing and troubleshooting different types of sandwich assays including ELISAs. Our laboratory in Woburn, MA is equipped with BSL2 cabinet, CO2 incubator, shakers, incubator-shakers, ELISA plate washer, ELISA plate reader, protein spotter, array imager, FRET and alphascreen plate reader, qPCR cycler, gel documentation system, freezers, refrigerators, fume hoods, centrifuges, pH meter, western blot apparatus, PCR machine, FPLC/HPLC instrument, microscope etc. Our mission is to accelerate R&D by providing high quality reagents and timely services.

59 Apsley St Hudson, MA, 01749 United StatesNovatein Biosciences is a rapidly growing biological reagents company specializing in the production and supply of immunoassay kits, reagents and proteins to researchers worldwide. We supply more than 10,000 different types of proteins and antibodies, and have one of the richest supplies of validated ELISA kits. In addition, we function as a contract research organization (CRO) assisting our clients in protein/ antibody production and immunoassay development and setup. As a manufacturer of reliable ELISA kits, our scientists are experts in performing and troubleshooting different types of sandwich assays including ELISAs. Our laboratory in Woburn, MA is equipped with BSL2 cabinet, CO2 incubator, shakers, incubator-shakers, ELISA plate washer, ELISA plate reader, protein spotter, array imager, FRET and alphascreen plate reader, qPCR cycler, gel documentation system, freezers, refrigerators, fume hoods, centrifuges, pH meter, western blot apparatus, PCR machine, FPLC/HPLC instrument, microscope etc. Our mission is to accelerate R&D by providing high quality reagents and timely services.

66 Herrick Road North Andover, MA, 01845 United StatesNegotiumBio's mission is to help clients develop options. Our specialty is supporting the development of your contract manufacturing network both to support near-term development needs, and longer-term commercialization. Our approach is based on enriching your teams' decision making process through thorough market knowledge, cost-modeling, agreement strategy and negotiations, as well as post-deal relationship management. Our team can support most technical outsourcing categories globally - drug substance/products, devices, CDx partnerships, GMP materials purchasing strategy, lab supplies/services and others. We're experienced in most drug modalities - including small/large molecule, cellular and gene therapies (vectors, CRISPR proteins, CAR-T, TCR, stem cell therapies, etc.).

5 Fortune Dr. Billerica, MA, 01821 United StatesNeoSome Life Sciences is a science driven Contract Research Organization. Our goal is to provide individualized service to support your research through all stages of drug discovery from proof of concept research to IND enabling studies. Our staff is experienced in performing drug efficacy evaluations in several animal models of human disease. We assist clients on the appropriate selection of animal disease models, study design, and bioanalytical assays to best fit your research goals. We pride ourselves on our personalized service focusing on scientific research.

3 Forbes Road Lexington, MA 02421 USANeoSome Life Sciences is a science driven Contract Research Organization. Our goal is to provide individualized service to support your research through all stages of drug discovery from proof of concept research to IND enabling studies. Our staff is experienced in performing drug efficacy evaluations in several animal models of human disease. We assist clients on the appropriate selection of animal disease models, study design, and bioanalytical assays to best fit your research goals. We pride ourselves on our personalized service focusing on scientific research.

3 Forbes Road Lexington, MA, 02421 United StatesNeoSome Life Sciences is a science driven Contract Research Organization. Our goal is to provide individualized service to support your research through all stages of drug discovery from proof of concept research to IND enabling studies. Our staff is experienced in performing drug efficacy evaluations in several animal models of human disease. We assist clients on the appropriate selection of animal disease models, study design, and bioanalytical assays to best fit your research goals. We pride ourselves on our personalized service focusing on scientific research.

4C Gill St Woburn, MA, 01801 United StatesSince 2007, NIS has been a trail-blazing CRO providing cryo-EM services. Diverse skill sets and state-of-the art technology, including more transmission electron microscopes than any provider in North America, help NIS make cryo-EM imaging and analysis accessible to companies of all sizes, and to teams across the drug discovery pipeline. As Thermo Fisher Scientific's recommended provider of cryo-EM in North America, we help our clients accelerate the development of new and life changing therapeutics. Service Areas: • Nanoparticle Characterization - including cryo-TEM imaging, particle morphology assessment and sizing, 3D reconstruction and tomography. Data is collected on our Tecnai T12 and Glacios transmission electron microscopes. • Structural Biology - including negative stain, cryo-EM sample prep and grid screening, high resolution Cryo-EM data collection and processing. Data is collected on our in-house Glacios and Titan Krios transmission electron microscopes. For all services, we offer rapid turn-around times for all deliverables, all-digital data and remote access via a secure web-based portal.

1000 Technology Park Drive Suite B Billerica, MA, 01821 United StatesAt Nuclera, our mission is to better human health by making proteins accessible. We believe that providing rapid access to high-quality, soluble, active proteins at the benchtop will allow researchers to accelerate their protein projects. Fail fast, succeed faster. Our eProtein Discovery™ system automates construct screening for the best soluble expression and purification yields of different proteins in under 24 hours. From there, protein scale-up happens the next day (up to the mg scale) right on the benchtop - delivering reliable protein in-hand in less than 48 hours. Nuclera’s technology integrates cell-free protein synthesis and digital microfluidics on smart cartridges, allowing rapid progress on protein projects through a benchtop, automated, high-throughput protein access system. Founded in 2013 by PhD students at the University of Cambridge, the company now has a presence in Cambridge, UK and Boston, MA employing over 100 employees.

22 Strathmore Road Suite 355 Natick, MA, 01760 United StatesNona Biosciences is a subsidiary of Harbour BioMed. Leveraging our proprietary Harbour Mice® H2L2 and HCAb fully human antibody transgenic mice technologies, Nona is committed to providing a total solution for therapeutic antibody discovery, engineering, and development for academics, biotech startups to biopharma giants. The HCAb platform produces human Vh single domain antibodies, providing multiple advantages for bispecific or multispecific antibody engineering in the ADC, mRNA, and CAR therapy technology areas.

22 Strathmore Road Suite 355 Natick, MA, 01760 United StatesNona Biosciences is a subsidiary of Harbour BioMed. Leveraging our proprietary Harbour Mice® H2L2 and HCAb fully human antibody transgenic mice technologies, Nona is committed to providing a total solution for therapeutic antibody discovery, engineering, and development for academics, biotech startups to biopharma giants. The HCAb platform produces human Vh single domain antibodies, providing multiple advantages for bispecific or multispecific antibody engineering in the ADC, mRNA, and CAR therapy technology areas.

24 Denby Road, Suite 116 Boston, Massachusetts, 02134 United StatesAt NovoVita, we offer comprehensive pathology solutions for drug discovery. Our services range from R&D, translational, and clinical up through phase 3 trials and we specialize in pharmacodynamic studies and clinical biomarker development. The equipment in our CLIA certified lab, has the latest cutting-edge technology including fully automated Ventana and Leica IHC platforms which are capable of multiplex and special genomic studies. Ask us for a quote today!

275 Grove Street Suite 2-400 Newton, MA, 02466 United StatesNovaseek Research specializes in data-driven biospecimen sourcing. Access to all biofluids from: -clinical chemistry -microbiology -heamatology with clinical results and advanced insight into clinical indications Using our proprietary CDNR platform, Novaseek mines real-time clinical data in the EMR to select immediately available remnant biospecimens from patients that match even the most complex requirements. Serial specimens, such as pre and post treatment cases, may also be requested. Customers can view, search, and download available clinical data (including longitudinal data) for each case including:  Current ICD10 diagnosis, medical history, and problem list  Medication lists  Chemo, radiation, and other treatment data  Results of laboratory testing  Narratives such as pathology, consult, and radiology reports Specimen types include blood, plasma, serum, urine, stool, peritoneal, and other fluids as well as slides, smears, and paraffin blocks/FFPE specimens.

28 Lothrop Street Newton, MA, 02460 United StatesNovaseek Research specializes in data-driven biospecimen sourcing. Access to all biofluids from: -clinical chemistry -microbiology -heamatology with clinical results and advanced insight into clinical indications Using our proprietary CDNR platform, Novaseek mines real-time clinical data in the EMR to select immediately available remnant biospecimens from patients that match even the most complex requirements. Serial specimens, such as pre and post treatment cases, may also be requested. Customers can view, search, and download available clinical data (including longitudinal data) for each case including:  Current ICD10 diagnosis, medical history, and problem list  Medication lists  Chemo, radiation, and other treatment data  Results of laboratory testing  Narratives such as pathology, consult, and radiology reports Specimen types include blood, plasma, serum, urine, stool, peritoneal, and other fluids as well as slides, smears, and paraffin blocks/FFPE specimens.

1380 Soldiers Field Road Boston, MA, 02135 United StatesNanoView provides exosome and extracellular vesicle characterization utilizing its proprietary ExoView Platform which enables multi-parametric and high-throughput single particle analysis.

910 Boston Turnpike Road Shrewsbury MA 01545 USANovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

25 First Street Cambridge, MA, 02141 United StatesNimbus Discovery is applying advances in computer-based drug discovery to unlock fundamental biological pathways.

245 First St, 18th Floor Cambridge, Massachusetts 02142NeoBioScience offers peptide synthesis, gene synthesis, genotyping, mutagenesis, monoclonal antibodies, polyclonal antibodies, custom synthesis, and cell based assay services.

Cambridge, MA United StatesNeoBioScience offers peptide synthesis, gene synthesis, genotyping, mutagenesis, monoclonal antibodies, polyclonal antibodies, custom synthesis, and cell based assay services.

One Concord Farms 490 Virginia Road Concord MA 01742Our Philosophy We're passionate about transforming people's lives, educating and empowering them on how to live more healthily through the power of nature. Our Vision To be a world leader of natural health and beauty, enabling people to live more healthily. Our Mission To improve the quality of people's lives by sharing our expertise and encouraging a more natural, holistic way of health, beauty, and well-being. Our Core Values Effectiveness Our formulations must benefit mind, body, and well-being, use potent herbs, oils, and extracts, and meet our own incredibly high standards of efficacy. Environment We are proud to be the first UK retailer to be certified CarbonNeutral®. Our belief in sustainability means we use only the wild, organic, and natural ingredients nature can afford to give. We avoid polluting, toxic, or harmful substances, and we don't over-package. Empowerment By listening to our customers and staff, and through sharing our knowledge, we can inspire and empower people to live more healthily and enjoy greater well-being.

One Concord Farms 490 Virginia Road Concord , MA , 01742 United StatesOur Philosophy We're passionate about transforming people's lives, educating and empowering them on how to live more healthily through the power of nature. Our Vision To be a world leader of natural health and beauty, enabling people to live more healthily. Our Mission To improve the quality of people's lives by sharing our expertise and encouraging a more natural, holistic way of health, beauty, and well-being. Our Core Values Effectiveness Our formulations must benefit mind, body, and well-being, use potent herbs, oils, and extracts, and meet our own incredibly high standards of efficacy. Environment We are proud to be the first UK retailer to be certified CarbonNeutral®. Our belief in sustainability means we use only the wild, organic, and natural ingredients nature can afford to give. We avoid polluting, toxic, or harmful substances, and we don't over-package. Empowerment By listening to our customers and staff, and through sharing our knowledge, we can inspire and empower people to live more healthily and enjoy greater well-being.

880 Winter Street Waltham, MA, 02451 United StatesNKT based therapeutics targeting NKT cells to treat sickle cell disease, autoimmune and inflammatory diseases, cancer, and asthma.

Attleboro, MA, USANoldus Information Technology develops software and technology in the application of tracking animal behavior.

360 Huntington Avenue Boston, MA 02115-5000 Center for Translational NeuroImagingThe Center for Translational NeuroImaging (CTNI) is located on Northeastern University’s campus adjacent to the Longwood Medical area. The Center’s mission is to provide services to the academic community interested in the areas of animal modeling and drug testing to aid in the diagnosis and treatment of CNS diseases. The CTNI develops proprietary technology and applications in the fields of magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), positron emission tomography (PET) and x-ray computed tomography (CT) to enhance preclinical research programs. The Center is committed to training the next generation of imaging scientists to meet the needs of the pharmaceutical and biotechnology industries.

12 Mill StNucleics offers automated DNA sequencing services, reagents, and DNA sequencing software.

101 Blanchard RoadNext Advance provides products that automate mundance tasks, such as rockers, syringes, and gel processors.

500 West Cummings Park, Suite 4550 Woburn, MA, 01801 United StatesNextcea Performs Drug Efficacy and Safety Assessments using Advanced LC-MS/MS Platforms

600 West Cummings Park, #6375Nextcea Performs Drug Efficacy and Safety Assessments using Advanced LC-MS/MS Platforms

Woburn, MA United StatesNextcea Performs Drug Efficacy and Safety Assessments using Advanced LC-MS/MS Platforms

245 First Street Cambridge, MA, 02142 United StatesR&D SERVICES NeoScientific is a dynamic and growing provider of high quality biology research reagents, tools, and custom services. PEPTIDE SYNTHESIS Custom Peptide Synthesis Peptide Library Peptide Modification GMP Peptide GlycoPeptides Peptide Nucleic Acids CUSTOM PROTEINS Bacterial Expression Yeast Expression Baculovirus Expression Mammalian Expression Scale Up Manufacture ANTIBODY SERVICES 45-Day mAb Polyclonal Antibodies Monoclonal Antibodies PO4-specific Antibodies Antibody 2.0: MassAb GENE & CELL ENGINEER Gene Synthesis Sub-Cloning Mutagenesis Primary Cells Isolation Cell-Based Assays Lentivirus Packaging Service Stable Cell Line

245 1st St., 18F Cambridge, MA, 02142 United StatesR&D SERVICES NeoScientific is a dynamic and growing provider of high quality biology research reagents, tools, and custom services. PEPTIDE SYNTHESIS Custom Peptide Synthesis Peptide Library Peptide Modification GMP Peptide GlycoPeptides Peptide Nucleic Acids CUSTOM PROTEINS Bacterial Expression Yeast Expression Baculovirus Expression Mammalian Expression Scale Up Manufacture ANTIBODY SERVICES 45-Day mAb Polyclonal Antibodies Monoclonal Antibodies PO4-specific Antibodies Antibody 2.0: MassAb GENE & CELL ENGINEER Gene Synthesis Sub-Cloning Mutagenesis Primary Cells Isolation Cell-Based Assays Lentivirus Packaging Service Stable Cell Line

36 Finnell Drive, Weymouth MA 02188Nereus Life Science (NLS) offers preclinical expertise performing FIRST-IN-ANIMAL and PROOF-OF-CONCEPT studies using translational models of human diseases. NLS aims to capitalize on methods that increase technical efficiency, particularly with animal husbandry practices, to reduce overhead and thereby our client's costs.

Weymouth, MA United StatesNereus Life Science (NLS) offers preclinical expertise performing FIRST-IN-ANIMAL and PROOF-OF-CONCEPT studies using translational models of human diseases. NLS aims to capitalize on methods that increase technical efficiency, particularly with animal husbandry practices, to reduce overhead and thereby our client's costs.

105 South St. Pittsfield MA 1201 USANuclea Biotechnologies offers gene signatures, assays, cancer cell lines, and studies for inflammation and oncology.

Pittsfield, MA, 01201 United StatesNuclea Biotechnologies offers gene signatures, assays, cancer cell lines, and studies for inflammation and oncology.

196 Boston Ave., Suite 2100 Medford, MA , 02155 United States

360 Merrimack Street, Building 9, Lawrence, MA, 01843 USANexcelom Biosciences provides cell counters, hemacytometers, and micro-ruled cover slips

Lawrence, MA United StatesNexcelom Biosciences provides cell counters, hemacytometers, and micro-ruled cover slips

100 Cummings Center, Suite 424J Beverly, MA 01915 USANew England PharmAssociates (NEPA) provides business solutions for both virtual and traditional 'bricks & mortar' companies in the pharmaceutical and life science sector.

410 Great Rd., Suite 4-2-2 Littleton, MA 01460 USANeo-Advent is a pre-clinical contract research organization specializing in drug formulation and bioanalytical development.

410 Great Rd. Suite 6-2-13 Littleton, MA, 01460 United StatesNeo-Advent is a pre-clinical contract research organization specializing in drug formulation and bioanalytical development.

320 Putnam Ave Cambridge, MA 02139 USAOur mission is to provide the highest-quality preclinical efficacy contract services for Central Nervous System (CNS), vascular and other diseases for our clients, including biotech and pharmaceutical companies, as well as academic investigators. We have extensive experience and expertise in preclinical modelling of CNS and vascular diseases, as well as a thorough understanding of all aspects of the drug development pathway. We possess special expertise in small animal surgery, drug delivery methods, and behavioral assessment methods. We provide high-level technical proficiency, as well as expert assistance in the planning, analysis and interpretation of preclinical efficacy studies. We're open, collaborative, and flexible with your needs.

320 Putnam Avenue Cambridge, MA, 02139 United StatesOur mission is to provide the highest-quality preclinical efficacy contract services for Central Nervous System (CNS), vascular and other diseases for our clients, including biotech and pharmaceutical companies, as well as academic investigators. We have extensive experience and expertise in preclinical modelling of CNS and vascular diseases, as well as a thorough understanding of all aspects of the drug development pathway. We possess special expertise in small animal surgery, drug delivery methods, and behavioral assessment methods. We provide high-level technical proficiency, as well as expert assistance in the planning, analysis and interpretation of preclinical efficacy studies. We're open, collaborative, and flexible with your needs.

129 Mill Street, Suite 11Northeast Laboratories provides services in pharmaceuticals, food, water, wastewater and indoor air quality.

Central Wharf Boston, MA 02110-3399The New England Aquarium, which opened in 1969, is a global leader in ocean exploration and marine conservation. The Aquarium is one of the premier visitor attractions in Boston, with over 1.3 million visitors a year, and a major public education resource. Vision and Mission The Aquarium is redefining what it means to be an aquarium: combining education, entertainment and action to address the most challenging problems facing the ocean. Through a wide variety of educational programs and conservation initiatives, we make a lasting impact globally.

Waltham, MA United StatesNova Biomedical develops and manufactures biosensor technology and analyzers.

21 Erie Street Cambridge , MA, 02139 United StatesThe Nikon BioImaging Lab in Cambridge, Massachusetts (USA) provides contract research services for microscope-based imaging and analysis to the biotech, pharma, and larger research communities. We are more than a core facility – our full-service capabilities include not only access to cutting-edge microscopy instrumentation and software, but also the services of expert biologists and microscopists, who are available to provide quality cell culture, sample preparation, data acquisition, and data analysis services. Leveraging our expertise in optics, image acquisition, and image analysis, Nikon Instruments is able to offer a wide range of solutions for live cell imaging and quality control in the stem cell and regenerative medicine industry including Contract Imaging Services. All work is charged on a simple per hour basis to ensure accessibility for all types of customers. Unlike other imaging facilities, the Nikon BioImaging Lab offers full-service cell culture capabilities – our experienced staff is equipped to handle cell thawing, maintenance, expansion, differentiation, and other essential operations. Nikon BioImaging Lab is even equipped to handle many higher-level cell culture procedures, such as the generation of stable cell lines. Nikon Instruments Inc. is a world leader in the development and manufacture of optical and digital imaging technology for biomedical applications. Now in its 104th year, Nikon provides complete optical systems that offer optimal versatility, performance and productivity. Cutting-edge instruments include microscopes, digital imaging products and software. Nikon Instruments is one of the microscopy and digital imaging arms of Nikon Inc., the world leader in digital imaging, precision optics and photo imaging technology. Nikon microscope systems help to expedite discovery to treatment.

113 Cedar Street Suite S-7 Milford MA 1757Omega PharmServices provides DMPK, dissolution studies, formulation development, chromatography, and spectrometry.

70 Bartzak Dr Holliston, Massachusetts, 01746 United StatesOligo Factory is a leader in DNA/RNA oligonucleotide synthesis at scale. We utilize innovative synthesis technology and production techniques along with exceptional customer service to meet the research community’s need for mid- to large-scale (25mg to kg+) oligo synthesis.

120 Jeffrey Ave. Holliston MA 1746 USAOligo Factory is a leader in DNA/RNA oligonucleotide synthesis at scale. We utilize innovative synthesis technology and production techniques along with exceptional customer service to meet the research community’s need for mid- to large-scale (25mg to kg+) oligo synthesis.

130 Turner St. Building 2, Suite 230 Waltham, MA, 02453 United StatesOlink Proteomics provides the most efficient tool available for high-multiplex, targeted human protein biomarker discovery, development and validation with high-throughput analysis, exceptional data quality, and minimal sample consumption. Olink's innovative technology uses DNA-coupled antibody pairs that provide dual recognition with a digital readout for exceptional readout specificity.

240 Salem Street Woburn, MA 10801 USAOrganix., a Massachusetts, USA based corporation, (www.organixinc.com) established in 1986, is an internationally recognized provider of Contract Research in Synthetic Organic and Medicinal Chemistry. Organix owns and operates a state-of-the-art facility in Woburn, MA staffed by Ph.D. level scientists who conduct chemistry of any complexity. We provide Custom Synthesis of Molecules in all Structural Classes, Design and Synthesis of New Chemical Entities, Structure Activity Relationship Studies, Hit-to-Lead Studies, Development and Optimization of Synthetic Procedures and Design and Synthesis of Drug Conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release an NCE in situ.

240 Salem St. Woburn, MA 01801 USAOrganix., a Massachusetts, USA based corporation, (www.organixinc.com) established in 1986, is an internationally recognized provider of Contract Research in Synthetic Organic and Medicinal Chemistry. Organix owns and operates a state-of-the-art facility in Woburn, MA staffed by Ph.D. level scientists who conduct chemistry of any complexity. We provide Custom Synthesis of Molecules in all Structural Classes, Design and Synthesis of New Chemical Entities, Structure Activity Relationship Studies, Hit-to-Lead Studies, Development and Optimization of Synthetic Procedures and Design and Synthesis of Drug Conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release an NCE in situ.

Organix, Inc. 240 Salem Street Woburn, MA, 01801 United StatesOrganix., a Massachusetts, USA based corporation, (www.organixinc.com) established in 1986, is an internationally recognized provider of Contract Research in Synthetic Organic and Medicinal Chemistry. Organix owns and operates a state-of-the-art facility in Woburn, MA staffed by Ph.D. level scientists who conduct chemistry of any complexity. We provide Custom Synthesis of Molecules in all Structural Classes, Design and Synthesis of New Chemical Entities, Structure Activity Relationship Studies, Hit-to-Lead Studies, Development and Optimization of Synthetic Procedures and Design and Synthesis of Drug Conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release an NCE in situ.

61 Moulton Street Cambridge, MA , 02138 United StatesOMAPiX is a spatial omics data company. We provide best-in-class spatial omics and data analytics services to our academic, Pharma, and biotech clients. OMAPiX is composed of industry experts in spatial omics. We provide end-to-end services using the spatial transcriptomics platforms from Vizgen (MERSCOPE) and Resolve Biosciences (Molecular Cartography). We provide spatial proteomics services using Ultivue platform. End-to-end Spatial Omics Services Description a. Front-end Scientific project consultation Technology consultation and guidance towards choosing the right technology based on the scientific question and experimental conditions Sample validation and standardisation Custom panel design b. Sample processing c. Data Analysis QC of spatial data Cell segmentation (per-pixel, machine learning or molecular coordinate-based) Identification of different cell-types using clustering methods Integration with imaging data (IHC, smFISH, H&E stains), Visium and scRNAseq data Integration of different spatial technologies (Xenium, CosMx, MERSCOPE, spatial proteomics) Spatial analysis (coexpression analysis, network analysis, cell-cell communication, microenvironment analysis) Technologies available Spatial Transcriptomics o Vizgen MERSCOPE – MERFISH Technology Single-cell and subcellular resolution highly multiplexed spatial transcriptomics Upto 500 genes, custom and pre-defined gene panels, possibility to perform additional antibody stainings (upto 6) Sample Types: Fresh Frozen, FFPE Species: any o Resolve Biosciences – Molecular Cartography Single-cell and subcellular resolution highly multiplexed spatial transcriptomics Up to 100 genes, custom panels, highly sensitive and specific Sample Types: Fresh Frozen, FFPE Species: any Spatial Proteomics o Ultivue Single-cell multiplexed spatially resolved proteomics Fixed and custom panels Upto 4-Plex and 8-Plex validated panels for tumour profiling. Sample Type: FFPE Species: mouse and human What you could use OMAPiX services for: Academic Research o tissue atlasing o basic and clinical research Pharma and Biotech o Therapeutic area agnostic Immuno-oncology Neurological diseases Infectious diseases Rare diseases o Across clinical development Target identification Target Validation Hit to Lead Lead Optimisation o Preclinical studies – biomarkers, safety, and Tox studies o Clinical Ph I and II – to test safety and early PoC; assess novel biomarkers of response, identify top indications for late stage development Ph III – Verify safety/efficacy profile; identify new indications / line expansions o Biomarker discovery o Cell and Gene Therapy - Assess biodistribution of the genetic payload - Assess cellular response - Assess target engagement, cellular/tissue specificity - Assess cellular toxicity - MoA - Research questions such as mechanism of responders and non-responders, T-cell exhaustion etc.

One Gateway Center 300 Washington Street, Suite 410 Newton, MA, 02458 United StatesOPEN Health brings together deep scientific knowledge, global understanding, and broad specialist expertise to support our clients in improving health outcomes and patient wellbeing. Our journey began with a vision to improve the lives of patients worldwide. This vision has become a reality with the integration of experts from Pharmerit International and Peloton Advantage to create a new unique entity equipped to be a global leader in HEOR and medical communications. We are united as one flexible organization, harnessing the power of the collective to solve complex challenges. Being built from cohesive partnerships across a range of specialist sectors gives us the ability to approach opportunities from fresh perspectives, creating solutions and innovations for market access and medical communications that are informed by the experience and knowledge of the many. Our global team of experts — many with PhD or PharmD degrees — work strategically alongside our client partners in Medical Affairs, Health Economics and Outcomes Research (HEOR), Market Access, and Commercial teams across a wide range of therapy areas. OPEN Health – Established as many. United as one.

201 Washington Street 201 Washington St. Boston, MA, 02108 United StatesOakLabs GmbH is a privately held company founded in 2011 to deliver most advanced R&D solutions by the combination of highly efficient detection methods with their in-silico modeling processes thus shortening long lasting R&D efforts at materially reduced expenses. OakLabs' team of biologists, chemists, mathematicians, quantum physicists and biostatisticians has extensive experience supporting successful research and discovery projects. OakLabs offers comprehensive services and contract research for industrial and academic research in the fields of biomarker discovery, gene expression analysis, advanced biocomputing, and development of software. Our core technologies integrate multidisciplinary excellence in: * Speciality lab services for gene expression analysis scalable to any type and size of project: * Machine learning for the discovery of advanced biomarker signatures for prognostics, diagnostics and prediction. * Software development compliant to relevant FDA regulations. * Our customers can expect services at predefined costs and fast delivery times due to an efficient integration of biocomputing and superior modeling. Research & Discovery We support your Research & Discovery projects with advances solutions for identification of informative biomarkers from any type of molecule using advanced machine learning algorithms. Our outstanding technology for genome-wide and pathway-focussed gene expression analysis provides exceptional data even from single cells and FFPE material. Development & Validation * Identification of novel biomarker with enhanced specificity and sensitivity * Reduction of sample numbers associated with tremendous savings due to machine learning algorithms * Improved planning security with reliable prediction of sample number * Efficient streamlining of the marker set towards required sensitivity and specificity * Superior speciality lab services for nucleic acid type biomarkers Transition to market OakLabs develops an IEC 62304 & FDA compliant software solution required to run your diagnostic test in diagnostic laboratories. Our team of expertise can also assist you with developing nucleic acid type testings.

n/a Cambridge, MA, 02114 United StatesOzgene provides genetically engineered mouse model services including the following: proprietary goGermline™ embryos, consulting/planning, design, development, breeding, characterization and phenotyping of genetically engineered mouse models.

n/a Cambridge, MA, 02114 United StatesOzgene provides genetically engineered mouse model services including the following: proprietary goGermline™ embryos, consulting/planning, design, development, breeding, characterization and phenotyping of genetically engineered mouse models.

800 Boylston Street, Ste 1410 United States Boston, MA, 02199 United States

35 South Street Hopkinton, MA 01748 USAOlympus Biotech offers preclinical to commercial-scale production of mammalian cell culture products.

34A Elm Street Pepperell, MA 01463Oak Hill Farm, located in Pepperell, MA, is situated on 17+ tranquil acres in a picturesque location at the end of a private drive. Conveniently located near the town center, the facility is easily accessed from Routes 111, 113, and 119. We provide personal care, catering to the specific needs of your horse, including unlimited, high quality hay; Poulin grains fed 3x per day; abundant shavings; individual turnout; a resident barn manager; and night checks. We welcome boarders of all levels and focus, from the recreational rider to the serious competitor. Our boarders include dressage riders, instructors, and trainers through Grand Prix as well as nationally-ranked competitors in reining.

68 West Street Southbridge, MA 01550 USAOptimum Technologies specializes in the development of biomedical devices that use light to sense, image, diagnose, and treat.

300 Brickstone Square Andover, MA, 01810 United StatesOra supports drug development for ocular diseases with consulting as well as compound synthesis, formulation development, analytical testing, and manufacturing services.

100 Acorn Park Drive, Cambridge, MA 02140 USAOncogene Science focuses on diagnostics for cancer and oncogenes.

One Broadway, Cambridge, MA 02142, USAOmixon’s mission is to help clinical, diagnostic and research labs to adopt NGS (Next Generation Sequencing) for the benefit of patients, by providing accurate and validated end-to-end NGS solutions, including both assays and software.

2 Shaker Road Shirley, MA, 01464 United StatesOxford Lasers provides laser micromachining and high speed imaging systems and subcontract services.

401 Edgewater Place Suite 300 Wakefield, MA, 01880-6208 United StatesDISTINCTIVE ADVANTAGES APPLICATION ・Artificially designed viral vector and plasmid construction ・Amplification of long DNA and sequences difficult to amplify by PCR ・Alternative to time-consuming and laborious E. coli cloning ・Recombinant phage production ・Efficient cloning of any DNA sequence, including repeat, cytotoxic and GC-rich sequences ・The amplification products can be used directly for E. coli transformation, etc. TECHNOLOGY OriCiro Cell-Free Cloning System is an innovative tool enabling cell-free assembly and amplification of circular DNA molecules without E. coli transformation and culture. This product can not only streamline your workflow dramatically but also widen the scope of your genetic engineering techniques. This product is composed of OriCiro Assembly Kit and OriCiro Amp Kit and designed to produce the maximum effect when used in combination although each kit can be used independently.

401 Edgewater Place Suite 300 Wakefield, MA, 01880-6208 United StatesDISTINCTIVE ADVANTAGES APPLICATION ・Artificially designed viral vector and plasmid construction ・Amplification of long DNA and sequences difficult to amplify by PCR ・Alternative to time-consuming and laborious E. coli cloning ・Recombinant phage production ・Efficient cloning of any DNA sequence, including repeat, cytotoxic and GC-rich sequences ・The amplification products can be used directly for E. coli transformation, etc. TECHNOLOGY OriCiro Cell-Free Cloning System is an innovative tool enabling cell-free assembly and amplification of circular DNA molecules without E. coli transformation and culture. This product can not only streamline your workflow dramatically but also widen the scope of your genetic engineering techniques. This product is composed of OriCiro Assembly Kit and OriCiro Amp Kit and designed to produce the maximum effect when used in combination although each kit can be used independently.

One Broadway, 14th Floor Cambridge, , MA , 02142 United StatesOncimmune, a global leader in biomarker services is focused on antibody (autoantibody) biomarker profiling in immuno-oncology, autoimmune and infectious diseases. Through its ImmunoINSIGHTS™ technology platform, the company provides insights to discover and validate novel biomarkers, improve treatment responses and adverse event (irAE) prediction, patient screening and diagnostic accuracy. Oncimmune is headquartered in the UK with operations in Germany, UK and USA.

99 Hayden Avenue Lexington, MA, 02421 United StatesPulmatrix is a clinical stage biotechnology company with an inhaled dry powder platform advancing a new generation of inhaled therapeutics.

1700 District Avenue Burlington, MA, 01803 United StatesPharmaLex is a leading provider of specialized services for the pharma, biotech and medical device industries. We guide you from early strategic planning activities and non-clinical requirements through clinical development, regulatory submission processes and post-approval / maintenance post-launch activities. Our experts use technology-enabled solutions to support you through the entire product lifecycle. We deliver exceptional results — going above and beyond the standard to deliver tailor-made solutions worldwide.

1 Presidential Way Suite 109 Woburn, MA, 01801 United StatesPharmaLex is a leading provider of specialized services for the pharma, biotech and medical device industries. We guide you from early strategic planning activities and non-clinical requirements through clinical development, regulatory submission processes and post-approval / maintenance post-launch activities. Our experts use technology-enabled solutions to support you through the entire product lifecycle. We deliver exceptional results — going above and beyond the standard to deliver tailor-made solutions worldwide.

10 Rogers Street Unit 1A Cambridge, MA, 02142 United StatesPsomagen, Inc. is a trusted contract research organization offering multiomics approaches to research and clinical customers. Our CLIA-certified, CAP-accredited US labs offer highly specialized multi-omics services anchored by our next generation sequencing (NGS) and 3rd Generation (nanopore, HiFi SMRT) portfolio. This includes options in genomics, transcriptomics, epigenomics, metagenomics, bioinformatics, and proteomics. We stay on the cutting edge of biotechnology by partnering with major players in the omics space, including 10x Genomics, Olink Proteomics, Illumina, and Pacific Biosciences. We frequently re-evaluate our customers' needs by adding new platforms and capabilities to our offerings.

200 Technology SquarePsomagen, Inc. is a trusted contract research organization offering multiomics approaches to research and clinical customers. Our CLIA-certified, CAP-accredited US labs offer highly specialized multi-omics services anchored by our next generation sequencing (NGS) and 3rd Generation (nanopore, HiFi SMRT) portfolio. This includes options in genomics, transcriptomics, epigenomics, metagenomics, bioinformatics, and proteomics. We stay on the cutting edge of biotechnology by partnering with major players in the omics space, including 10x Genomics, Olink Proteomics, Illumina, and Pacific Biosciences. We frequently re-evaluate our customers' needs by adding new platforms and capabilities to our offerings.

725 Concord Avenue Cambridge, MA 02138 USAPROMETRIKA offers expertise in data management, biostatistics and medical writing.

Boston, MABlending your drug discovery needs with our scientific expertise to deliver timely pre-clinical research excellence.

12 Cabot Road Suite 12 A&T Woburn, Massachusetts, 01801 United StatesAbsorption Systems is a nonclinical CRO emphasizing the most highly relevant physiological models to further research accuracy from post-discovery through post-market surveillance. We partner with you to overcome ADMET barrier in the development of drugs and devices to improve human outcomes. Our research covers in vivo, ex vivo, in vitro from R&D through commercial GMP. Absorption Systems, ACF Division provides analytical support for in vivo and ex vivo gene therapies, cell therapies and immunotherapies, CAR-T, T-Cell - in vitro cell based potency assay development, in vivo biodistribution, toxicology and efficacy. ACF provides GMP-compliant gene/cell therapy commercial potency release testing at its FDA/MHRA inspected facility.

19 Presidential Way Woburn, MA, 01801 United StatesPace Analytical Life Sciences (PLS) provides CDMO / CRO services to help improve human health by supporting the Pharmaceutical / Biopharmaceutical / Biologics innovators - to support Pharmaceutical Drug Development, Pharmaceutical Manufacturing, and Biopharmaceutical / Biologics manufacturing. Our teams have world-class expertise with small molecule, biologic, oligonucleotide and hybrid products: • Characterize new therapeutic molecules (preformulation) • Synthetic small molecules, • Biologics such as proteins, peptides, antibodies, antibody drug conjugates • Gene therapies such as oligonucleotides • Formulation development • Lyophilization process development • Spray-drying , Hot-Melt Extrusion (HME), Nano-milling • Phase-appropriate analytical development • Test Article Preparation • Clinical Trial Materials (CTM) - Sterile & non-Sterile dosages through Phase 2 • Clinical Packaging Full service, cGMP-compliant, Chemistry and Microbiology contract laboratory services. As an FDA-registered, GMP contract laboratory services provider, we help to ensure the quality of marketed pharmaceutical products by providing chemistry and microbiology services: • Facility Environmental Monitoring • Raw Materials Clearance Programs • Finished Product Testing • Method Development and Validation • In-process & Finished Product Testing • ICH Stability Storage & Testing • Reference Standards Programs • Extractable / Leachable studies • Dissolution drug release, • Elemental metals, • Microbiology Testing Services • Microbial limits, • Sterility Pace Analytical Life Sciences (PLS) provides services to help improve human health. We provide contract product development to help bring new therapies to market and contract laboratory services to ensure the purity, potency, safety, efficacy, and shelf life of pharmaceutical and medical products.

101 Tremont St Boston, MA 02108Precision for Medicine supports the discovery, development, clinical trial work, and implementation of biomarkers essential for targeting patients more precisely and effectively. This dynamic new field requires novel services that aren’t currently offered by traditional research organizations. We provide an uncommon array of talent, products and services to enable our pharmaceutical and life sciences clients to take advantage of new advancements in science and stay ahead of regulatory changes. Our team encompasses scientists, clinical trial experts and technical specialists that support our trailblazing clients through: A state-of-the-art biorepository and laboratory Biomarker identification through analysis of ’omics and clinical data A comprehensive approach to companion diagnostic product development Fully integrated and global clinical trial capabilities

ProMedDx, LLC 10 Commerce Way Norton, MA, 02766 United StatesPrecision for Medicine supports the discovery, development, clinical trial work, and implementation of biomarkers essential for targeting patients more precisely and effectively. This dynamic new field requires novel services that aren’t currently offered by traditional research organizations. We provide an uncommon array of talent, products and services to enable our pharmaceutical and life sciences clients to take advantage of new advancements in science and stay ahead of regulatory changes. Our team encompasses scientists, clinical trial experts and technical specialists that support our trailblazing clients through: A state-of-the-art biorepository and laboratory Biomarker identification through analysis of ’omics and clinical data A comprehensive approach to companion diagnostic product development Fully integrated and global clinical trial capabilities

10 Commerce Way Norton, MA, 02766 United StatesPrecision for Medicine supports the discovery, development, clinical trial work, and implementation of biomarkers essential for targeting patients more precisely and effectively. This dynamic new field requires novel services that aren’t currently offered by traditional research organizations. We provide an uncommon array of talent, products and services to enable our pharmaceutical and life sciences clients to take advantage of new advancements in science and stay ahead of regulatory changes. Our team encompasses scientists, clinical trial experts and technical specialists that support our trailblazing clients through: A state-of-the-art biorepository and laboratory Biomarker identification through analysis of ’omics and clinical data A comprehensive approach to companion diagnostic product development Fully integrated and global clinical trial capabilities

10 Commerce Way Norton, MA, 02766 United StatesPrecision for Medicine supports the discovery, development, clinical trial work, and implementation of biomarkers essential for targeting patients more precisely and effectively. This dynamic new field requires novel services that aren’t currently offered by traditional research organizations. We provide an uncommon array of talent, products and services to enable our pharmaceutical and life sciences clients to take advantage of new advancements in science and stay ahead of regulatory changes. Our team encompasses scientists, clinical trial experts and technical specialists that support our trailblazing clients through: A state-of-the-art biorepository and laboratory Biomarker identification through analysis of ’omics and clinical data A comprehensive approach to companion diagnostic product development Fully integrated and global clinical trial capabilities

1 Broadway Cambridge, MA, 02142 United StatesProteros Biostructures offers proteins, screening services, assay development, structure optimization, drug discovery, and crystallography.

10 Powers Street Leominster, MA 01453 USAFounded in 2003, PolyOrg is a Massachusetts-based biotechnology company that specializes in the manufacturing of specialty chemical products used in the life science industry. In addition to offering our 350+ catalog products, we help our customers develop new products, improve existing products, and transition their existing products from research to manufacturing. We perform contract research, process development, custom synthesis, and manufacturing for clients in various science industries. The catalog compounds we offer fall into the following categories: acids, acid derivatives, amidites, amines, amino acids, amino acid derivatives, anhydrides, aromatics, aziridines, biotinylated compounds, carbohydrates, chlorinated compounds, coumarins, disulfides, fine chemicals, fluorescent compounds, halogenated compounds, heterocycles, indoles, isocyanides, linkers, long chain linkers, napthyridines, nitrile, nucleobase, nucleosides, nucleoside reagents, oligonucleotide reagents, phosphates, phosphonates, phosphoramidites, PNA Backbone, PNA Intermediates/Reagents, PNA Monomers, purine, pyrenes, pyrmidines, reagents, silyl compounds, succinates, sulfonyl compounds, sulfurizing reagent, thiazoles. PolyOrg, Inc. is also the smart choice for custom organic synthesis. We assist many life science, pharmaceutical, and biotech companies along with research universities in all of their custom organic synthesis work. As you can see from our catalog, our chemists have a wide ranging knowledge in the organic and medical chemistry fields. We have successfully completed over 2000+ custom synthesis projects over the last 15 years.

4 Burlington Woods Drive Burlington, MA, MA 01803 United States Analytical Excellence — Enabling Tomorrow’s Therapeutics ProtaGene is a world-leading CRO partner for the biopharmaceutical and cell and gene therapy industries. From research through product commercialization, we provide the most advanced, integrated, and complete protein and gene analytic capabilities and packages for biologic therapeutics as well as cell and gene therapy platforms. Our deep history of analytical leadership in protein-based therapeutics stems from the merger of Protagen Protein Services in Europe and BioAnalytix in the US. In 2021, GeneWerk’s unique capabilities in vector safety, integration site analysis, and bioinformatics were added to our portfolio, establishing ProtaGene. Our combined protein- and gene-based analytical platforms make it the leading analytic service provider across the biopharmaceutical and cell and gene therapy development spaces. The organization operates four sites in Europe and North America and works in advanced therapeutic platforms with leading biopharmaceutical and gene therapy companies worldwide. 25 years of market experience and the comprehensive spectrum of validated analytical methods ensure the highest quality for customers in the pharmaceutical, biotech and life science industry.

790 Memorial Drive Cambridge, MA, 02139 United States Analytical Excellence — Enabling Tomorrow’s Therapeutics ProtaGene is a world-leading CRO partner for the biopharmaceutical and cell and gene therapy industries. From research through product commercialization, we provide the most advanced, integrated, and complete protein and gene analytic capabilities and packages for biologic therapeutics as well as cell and gene therapy platforms. Our deep history of analytical leadership in protein-based therapeutics stems from the merger of Protagen Protein Services in Europe and BioAnalytix in the US. In 2021, GeneWerk’s unique capabilities in vector safety, integration site analysis, and bioinformatics were added to our portfolio, establishing ProtaGene. Our combined protein- and gene-based analytical platforms make it the leading analytic service provider across the biopharmaceutical and cell and gene therapy development spaces. The organization operates four sites in Europe and North America and works in advanced therapeutic platforms with leading biopharmaceutical and gene therapy companies worldwide. 25 years of market experience and the comprehensive spectrum of validated analytical methods ensure the highest quality for customers in the pharmaceutical, biotech and life science industry.

3 Federal St. Suite 300 Billerica, MA, 01821 United StatesMomentum Biotechnologies (“formerly known as PureHoney Technologies”) is a specialized mass spectrometry services provider and discovery partner to clients in the fields of pharma, biopharma, biotech, gene therapy and toxicology. Our core team of scientists and engineers have been working together since 2000 when they built the RapidFire technology (acquired by Agilent in 2011) and have been serving clients using RapidFire-MS since 2004. Since then, we have continued to combine cutting-edge mass spectrometry technology and creative problem solving to address our clients’ toughest assay challenges. We are the leading provider of solution phase Affinity Selection Mass Spectrometry (ASMS) for RNA and protein targets. We help clients identify leads for novel mechanisms of action such as protein degradation/molecular glues, protein-protein interaction disruption (ASMS), and irreversible binding (Covalent Screening). We offer functional screens on RapidFire-MS, potency assays, and biomarker quantification and can additionally support Cell and Gene Therapy applications through ICP-MS analysis. As scientists, our goal is to accelerate the design-build-test cycle for our clients’ therapeutics. Clients will speak with a PhD from the first phone call to customize assay solutions for their projects. We pride ourselves on rapid turnaround of the highest quality data, thus maintaining the momentum of our clients’ projects.

17 Briden Street #309 WORCESTER, MA, 01605 United StatesPackGene is a world-leading CDMO company focus on providing end-to-end gene therapy solutions. Founded in 2014, PackGene now has offices in Guangzhou (CN), Houston (US) and Zurich (CH). PackGene provides economical, reliable, and scalable AAV viral vector, plasmid DNA, and mRNA production to support programs from early-stage drug discovery, preclinical development to IND enabling and clinical studies. Our proprietary π-Alpha™ 293 AAV High-yield Platform uses uniquely designed RC plasmid in the triple-plasmid transfection system to increase AAV production by 3 to 8 fold. PackGene's mission is to accelerate gene therapy product development by providing an integrated one-stop solution including plasmid, viral vector, fill-finish and QC analytical services for the gene therapy industry.

1 Innovation DR Biotech3 #420 Worcester, Massachusetts, 01605 United StatesPackGene is a world-leading CDMO company focus on providing end-to-end gene therapy solutions. Founded in 2014, PackGene now has offices in Guangzhou (CN), Houston (US) and Zurich (CH). PackGene provides economical, reliable, and scalable AAV viral vector, plasmid DNA, and mRNA production to support programs from early-stage drug discovery, preclinical development to IND enabling and clinical studies. Our proprietary π-Alpha™ 293 AAV High-yield Platform uses uniquely designed RC plasmid in the triple-plasmid transfection system to increase AAV production by 3 to 8 fold. PackGene's mission is to accelerate gene therapy product development by providing an integrated one-stop solution including plasmid, viral vector, fill-finish and QC analytical services for the gene therapy industry.

177 Huntington Avenue, 17th Floor Boston, Massachusetts, 02115 United StatesSince 2014 ProRelix Research has been supporting our clients with outstanding clinical research services. The successful growth of ProRelix Research has been achieved by putting high quality and client focus at the heart of everything we do. We leverage our experience and expertise at the early stages of discussions with our clients to freely advise them on the optimal project plan. We then reach decision with each client on the scope of service, timelines and budget. ProRelix Research then commits to deliver those services on time and within budget – according to our End-to-End Guarantee. Our commitment to guaranteed delivery is unique in the clinical research environment which is otherwise notable for the routine occurrence of delays and cost overruns. Acting through Pharmaceutical, Medical Device Research teams, and with a comprehensive portfolio of services, we offer a flexible approach to ensure ProRelix Research optimally support the unique needs of each client. This could mean providing regulatory consultancy to a small company at the early stages of development programme, through to provision of full services to a company performing an international mega trial to support registration of their product. Whatever the size and scope of the project, each receives the same level of attention to detail and commitment to delivery of a high quality service within budget and to timelines agreed.

2 Dundee Park, Mailbox 76 United States Andover, MA, 01810 United States We provide expertise specific to your development program on a variable cost and on-demand basis or as a permanent employee. Our virtual bench of “precision medicine athletes” provide a natural extension of your existing operations in a flexible and unbundled fashion, increasing enterprise value within your product portfolio. Let us help you successfully develop superior, targeted therapies to improve patients outcomes. Experts in Collaborative Strategies for Precision Medicine Development™

METROPOLIS CENTERParexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.

900 Chelmsford StreetParexel provides bioequivalence studies as well as clinical services across Phase I to Phase III of drug development including dose escalation, drug-drug interaction, biomarkers, first-in-man studies, ADME, imaging, and clinical research services.