Science Park 1 Saarbrücken, Saarland, 66123 GermanyAcross Barriers GmbH was set up with the aim to provide new technologies and services for the pharmaceutical, cosmetics and chemical industries in the research and development sector. In-vitro models of cell and tissue systems serve as the basis for the technology used simulating the transport of substances and formulations across biological barriers. In this process conclusions regarding permeability and absorption can be drawn. The clients of Across Barriers GmbH benefit from such studies in the following fields: - GLP and GMP certified. - Substances not suitable for development can be readily distinguished during the early phases and excluded at this point. - As a result time and financial costs accrued during the development of an active substance can be significantly lowered. - High-cost and ethically problematic animal experiments can also be reduced to a minimum. - In-vitro models permit the classification of formulations that can be administered via new forms, for example inhalation aerosols or transdermal application. In addition they allow mechanistic conclusions on the in-vivo behavior of substances. - Across Barriers has laboratories for biological and radioactive operations - Since 2003 the company has the permission to work with narcotics agents With the “in vitro bioequivalence” concept Across Barriers helps generic companies to avoid or reduce clinical studies Across Barriers supports its customer by answering a deficiency letter on the basis of in vitro studies Across Barriers is in the position to provide methods for classifying substances in accordance with the BCS guidelines regulated by the FDA, consequently offering the possibility of being released of in-vivo bio equivalence and in-vivo bioavailability studies. The use of tissue and cell cultures in the pre-clinic research consequently represents an intelligent and innovative step towards a faster, safer and less expensive development of modern active substances and formulations. Across Barriers develops and distributes validated models in order to secure an advantage in forward-looking technology for its clients.

1 Science Park Saarbrücken, SL, 66123 GermanyAcross Barriers GmbH was set up with the aim to provide new technologies and services for the pharmaceutical, cosmetics and chemical industries in the research and development sector. In-vitro models of cell and tissue systems serve as the basis for the technology used simulating the transport of substances and formulations across biological barriers. In this process conclusions regarding permeability and absorption can be drawn. The clients of Across Barriers GmbH benefit from such studies in the following fields: - GLP and GMP certified. - Substances not suitable for development can be readily distinguished during the early phases and excluded at this point. - As a result time and financial costs accrued during the development of an active substance can be significantly lowered. - High-cost and ethically problematic animal experiments can also be reduced to a minimum. - In-vitro models permit the classification of formulations that can be administered via new forms, for example inhalation aerosols or transdermal application. In addition they allow mechanistic conclusions on the in-vivo behavior of substances. - Across Barriers has laboratories for biological and radioactive operations - Since 2003 the company has the permission to work with narcotics agents With the “in vitro bioequivalence” concept Across Barriers helps generic companies to avoid or reduce clinical studies Across Barriers supports its customer by answering a deficiency letter on the basis of in vitro studies Across Barriers is in the position to provide methods for classifying substances in accordance with the BCS guidelines regulated by the FDA, consequently offering the possibility of being released of in-vivo bio equivalence and in-vivo bioavailability studies. The use of tissue and cell cultures in the pre-clinic research consequently represents an intelligent and innovative step towards a faster, safer and less expensive development of modern active substances and formulations. Across Barriers develops and distributes validated models in order to secure an advantage in forward-looking technology for its clients.

House of BioHealth 29, Rue Henri Koch L-4354 Esch-sur-Alzette LuxembourgATERA is a tissue engineering company specialized in research and development, validation, manufacturing and commercialization of advanced human tissue models to address the growing demand for reliable, cost-effective and high-quality test methods for product evaluation, gradually reducing and replacing animal experimentation, for both industrial safety & efficacy testing as well as medical research.

Kochstrasse 4 Trier, RLP, 54290 GermanyDesign and Communication Studio

Kochstrasse 4 Treir, RLP, 54290 GermanyDesign and Communication Studio

4 Rue Jean-Pierre Brasseur Luxembourg, Luxembourg, 1258 LuxembourgWe are a consulting firm specialised in the fields of Global HEOR, Access and Pricing, informing Access and HTA strategy from early to late stage product development. For launch preparation, we provide integrated team of experts who develop all necessary core deliverables and strategic guidance for successful HTA submissions.

2 Rue du Chateau d'Eau Leideleng, Distrikt Luxemburg, 3364 LuxembourgCogent expedites the secure transfer of large data files between domestic and global locations including the U.S., U.K., Europe, Japan, China, Korea, Singapore, Australia, and Brazil. [NASDAQ: CCOI] Cogent is a Tier 1 Global Internet Service Provider with the most interconnected network in the world – connecting to 6700 networks and 1200 Data Centers in over 200 markets spanning 45 countries. Approximately 21% of the world’s Internet traffic travels our network daily. Our core product offerings include Dedicated Internet Access, Ethernet Point-to-Point, Ethernet VPLS, SDWAN, and Colocation services offered over our award-winning fiber optic, IP data-only network.

Luxembourg City, Luxembourg District LuxembourgDiagenics provides in vitro diagnostics and marketing for their cardiology, neurology, and gynecology products and research.

5, rue GOethe L-1637 Luxemburg LuxemburgDiagenics provides in vitro diagnostics and marketing for their cardiology, neurology, and gynecology products and research.

6 rue Dominique Lang L-3505 Dudelange LuxembourgDISTRIBIO is a specialist in Laboratory equipment, particularly DNA sequencers and oligonucleotides synthesizers. Used or new instruments with service and maintenance. The company has 30 years experience in the field of biotechnology.

45 Ave François Clément MONDORF, 5612 LuxembourgDISTRIBIO is a specialist in Laboratory equipment, particularly DNA sequencers and oligonucleotides synthesizers. Used or new instruments with service and maintenance. The company has 30 years experience in the field of biotechnology.

Saarbrücken, SL GermanyElexoPharm offers medicinal chemistry in support of hit identification, hit to lead, and lead optimization services.

Im Stadtwald, Geb. A1 Saarbrücken, 66123 GermanyElexoPharm offers medicinal chemistry in support of hit identification, hit to lead, and lead optimization services.

29 Boulevard du Prince Henri Luxembourg, 1724 LuxembourgEREVAS develops intuitive, data-driven digital solutions to help you generate evidences to improve decision-making : - Web Apps running directly in the browser of any device (laptop, iPad, smartphone) - Health Eco models development: Excel/VBA, R/Shiny, … - Tailored-made solutions

13 Rue du Bois de la Champelle Vandœuvre-lès-Nancy, Grand Est, 54500 FranceETAP-LAB – Preclinical CRO supporting therapeutic innovations for over 35 years. A recognized European preclinical CRO delivering efficient, cost-effective services to pharmaceutical, biotech/medtech, and nutraceutical companies across four key areas of expertise: • BRAINXPLORE – Expert in neurology and CNS disorders with integrated preclinical solutions for neurodegeneration and behavioral pharmacology. ​​ • SKINAXIS – Pharmacology efficacy in dermatology and skin disorders – supporting the development of drugs, regenerative therapies, and medical devices – with a strong track record of successful market launches. • STROK@LLIANCE – Expert in neurovascular diseases and stroke, combining human-based and advanced in vivo models developed in collaboration with PhIND (INSERM-UniCaen) • SYNCROSOME – Cardiovascular & cardiorespiratory pharmacology, with 25+ years of international expertise. We support drug discovery phases ranging from in vitro lead optimization to non-GLP in vivo studies (POC, PK/PD, safety pharmacology), evaluating drug candidates (small molecules, antibodies, biotherapy…), medical devices and nutraceuticals. Our capabilities include advanced in vitro and in vivo models, alternative methods (organ-on-chip, NAMs), analytical services, imaging, and cutting-edge technological platforms. Core services: • In vitro & in vivo studies • PK/PD & non-regulatory safety • Analytical services • Scientific consulting Why partner with ETAP-LAB: • Highly responsive, client-focused approach (CSAT 2024: 100%) • 100+ validated models with optimized study designs • 60–80 projects delivered annually • Skilled team (~45 experts) • Reduced scientific, statistical, and regulatory risks • High translational value data for decision-making • Strong ethics, transparency, and ISO9001-certified quality system

13 rue du Bois de la Champelle Vandoeuvre-lès-Nancy, 54500 FranceETAP-LAB – Preclinical CRO supporting therapeutic innovations for over 35 years. A recognized European preclinical CRO delivering efficient, cost-effective services to pharmaceutical, biotech/medtech, and nutraceutical companies across four key areas of expertise: • BRAINXPLORE – Expert in neurology and CNS disorders with integrated preclinical solutions for neurodegeneration and behavioral pharmacology. ​​ • SKINAXIS – Pharmacology efficacy in dermatology and skin disorders – supporting the development of drugs, regenerative therapies, and medical devices – with a strong track record of successful market launches. • STROK@LLIANCE – Expert in neurovascular diseases and stroke, combining human-based and advanced in vivo models developed in collaboration with PhIND (INSERM-UniCaen) • SYNCROSOME – Cardiovascular & cardiorespiratory pharmacology, with 25+ years of international expertise. We support drug discovery phases ranging from in vitro lead optimization to non-GLP in vivo studies (POC, PK/PD, safety pharmacology), evaluating drug candidates (small molecules, antibodies, biotherapy…), medical devices and nutraceuticals. Our capabilities include advanced in vitro and in vivo models, alternative methods (organ-on-chip, NAMs), analytical services, imaging, and cutting-edge technological platforms. Core services: • In vitro & in vivo studies • PK/PD & non-regulatory safety • Analytical services • Scientific consulting Why partner with ETAP-LAB: • Highly responsive, client-focused approach (CSAT 2024: 100%) • 100+ validated models with optimized study designs • 60–80 projects delivered annually • Skilled team (~45 experts) • Reduced scientific, statistical, and regulatory risks • High translational value data for decision-making • Strong ethics, transparency, and ISO9001-certified quality system

Val Fleuri 23 Luxemburg, 1526 United KingdomEurofins provides integrated services as well as medicinal chemistry, ADME screening, DMPK, in vivo pharmacology, bioanalytical, and safety toxicology services.

Nordstrasse 7 D-66780 Rehlingen, GermanyAfrican Copal Bark CO2-se extract,Ajowain Fruit CO2-se extract (organic), DE-ÖKO-013,Allspice Berries CO2-to extract (organic), Jamaica-Type, DE-ÖKO-013,Allspice Berries CO2-to extract, Jamaica-Type,Amaranth Seed CO2-to extract (organic), DE-ÖKO-013,Angelica Root CO2-se extract,Antimicrobial Blend,Arnica Flower CO2-to extract (organic), 4 % Sesquiterpene lactones, DE-ÖKO-013,Arnica Flower CO2-to extract, 4 % Sesquiterpene lactones,Balm Leaf CO2-se extract (organic), DE-ÖKO-013,Balm Leaf CO2-to extract,Balm Leaf CO2-to extract (organic), DE-ÖKO-013,Basil Leaf CO2-se extract,Black Cumin CO2-to extract (organic), DE-ÖKO-013,Borage Seed CO2-to extract,Borage Seed CO2-to extract (organic), DE-ÖKO-013,Butter CO2-se extract, Cryst. Type,Butter CO2-se extract, Dist. Type,Calamus Root CO2-se extract,Camomile Flower CO2-se extract (integr),Camomile Flower CO2-to extract (integr),Camomile Flower CO2-to extract (organic), DE-ÖKO-013,Caraway CO2-se extract,Caraway CO2-se extract (organic), DE-ÖKO-013,Cardamom CO2-se extract,Cardamom CO2-se extract (organic), DE-ÖKO-013,Cardamom CO2-to extract,Cardamom CO2-to extract (organic), DE-ÖKO-013,Carrot CO2-to extract (organic), with sunflower oil, DE-ÖKO-013,Carrot Seed CO2-se extract,Carrot-Jojoba CO2-to extract (organic), DE-ÖKO-013,Celery Seed CO2-to extract,Chia Seed (Spanish Sage) CO2-to extract (organic), DE-ÖKO-013,Chili CO2-to extract (organic), 3,1 % Capsaicinoids, DE-ÖKO-013,Chili CO2-to extract, 10 % Capsaicinoids,Chili CO2-to extract, 5 % Capsaicinoids,Cinnamon Bark Burmanii CO2-to extract (organic), DE-ÖKO-013,Cinnamon Bark Cassia CO2-to extract,Cinnamon Bark Ceylanicum CO2-se extract,Cinnamon Bark Ceylanicum CO2-se extract (organic), DE-ÖKO-013,Clove Bud CO2-se extract,Clove Bud CO2-se extract (organic), DE-ÖKO-013,Coconut CO2-se extract (organic) DE-ÖKO-013,Coffee CO2-to extract,Coffee CO2-to extract (organic), DE-ÖKO-013,Coriander CO2-se extract,Coriander CO2-to extract (organic), DE-ÖKO-013,Coriander CO2-to extract, 25 % Essent. Oil,Cumin Seed CO2-to extract (organic), DE-ÖKO-013,Curcuma Longa CO2-to extract,Curcuma Longa CO2-to extract (organic), DE-ÖKO-013,Curcuma Xanthorrhiza CO2-se extract,Curcuma Xanthorrhiza CO2-se extract (organic), DE-ÖKO-013,Curcuma Xanthorrhiza CO2-to extract (organic), DE-ÖKO-013,Dill Seed CO2-se extract, Carvone Type,Dill Seed CO2-se extract, Dillapiol Type,Evening Primrose Seed CO2-to extract (organic), DE-ÖKO-013,Fennel CO2-se extract, Bitter Type,Fenugreek Seed CO2-to extract (organic), DE-ÖKO-013,Feverfew CO2-to extract,Flavoxan 14, Rosemary Antioxidant formulation,Flavoxan 25, Rosemary Antioxidant formulation,Frankincense Carteri CO2-se extract,Frankincense Serrata CO2-se extract,Galangal Root CO2-to extract (organic), DE-ÖKO-013,Galbanum CO2-se extract,Garlic CO2-to extract D/E = 50:1,Ginger CO2-extract, powder, 20 % Gingerols,Ginger CO2-se extract,Ginger CO2-to extract,Ginger CO2-to extract (organic), DE-ÖKO-013,Ginger Hot Flavor CO2-to extract,GlucodOX™ Liquid, Guggul-MCT810,Gromwell Root CO2-to extract, standardised and deodorised,Hazelnut CO2-se extract,Hazelnut CO2-se extract (organic), DE-ÖKO-013,Hazelnut CO2-se extract alcohol soluble,Hop CO2-se extract,Hop CO2-to extract,Hop CO2-to extract, flavor reduced, standardised,Juniper Berries CO2-se extract,Kava-Kava Root CO2-to extract, 60 % Kavapyrones,Kiwi Seed CO2-to extract,Lavender Flower CO2-se extract,Lemon Myrtle CO2-se extract (organic), DE-ÖKO-013,Licorice root CO2-to extract with MCT Oil, Variety Uralensis,Lovage Root CO2-se extract,Lovage Root CO2-to extract,Mace CO2-se extract,Mango Ginger CO2-to extract,Marigold CO2-to extract, < 0,1 % Carotenoides, (NOP-organic cert. by CERES),Marigold Flower CO2-to extract (integr),Marigold Flower CO2-to extract (integr), < 0,1 % Carotenoides,Marigold Flower CO2-to extract (organic), DE-ÖKO-013,Marjoram Leaf CO2-se extract,Massoia Bark CO2-se extract,Millet Seed CO2-to extract (organic), DE-ÖKO-013,Musk Seed CO2-se extract,Myrrh CO2-se extract,Nutmeg CO2-se extract (organic), DE-ÖKO-013,Oregano Leaf CO2-se extract (organic), Phenol Type, DE-ÖKO-013,Oregano Leaf CO2-se extract, Terpineol Type,Oregano Leaf CO2-to extract (organic), Phenol Type, DE-ÖKO-013,Oregano Leaf CO2-to extract, Phenol Type,Orris Root CO2-se extract,Orris Root CO2-se extract, 1 % Irone,Orris Root CO2-se extract, 3 % Irones,Paprika CO2-to extract (organic), 40000 C.U., DE-ÖKO-013,Paprika extract, 80000 C.U.,Paprika extract, water dispersible, 40000 C.U.,Parsley Seed CO2-se extract,Peanut CO2-se extract,Peppermint Leaf CO2-se extract,Pomegranate Seed CO2-to extract,Pomegranate Seed CO2-to extract (organic), DE-ÖKO-013,Raspberry Seeds CO2-to extract, (NOP-organic cert. by CERES),Rhatany Root CO2-to extract, standardised,Rosehip CO2-to extract (organic), DE-ÖKO-013,Rosehip Seed CO2-to extract (organic), DE-ÖKO-013,Rosemary Antioxidant extract (organic), 14 % Diterpene Phenols, DE-ÖKO-013,Rosemary Antioxidant extract (organic), 25 % Diterpene Phenols, DE-ÖKO-013,Rosemary Antioxidant extract, 14 % Diterpene Phenols,Rosemary Antioxidant extract, 25 % Diterpene Phenols,Rosemary Antioxidant extract, powder (organic), 25 % Diterpene Phenols, DE-ÖKO-013,Rosemary Antioxidant extract, powder, 25 % Diterpene Phenols,Rosemary Antioxidant extract, water dispersible, 14 % Diterpene Phenols,Rosemary CO2-se extract,Rosemary CO2-se-plus extract,Rosemary CO2-se-plus extract (organic), DE-ÖKO-013,Rosemary CO2-to extract (organic), Camphor Type, DE-ÖKO-013,Sage Antioxidant extract, 25 % Diterpene phenols,Sage Antioxidant extract, 35 % Diterpene Phenols,Sage Officinalis CO2-se extract,Sage Triloba (syn. Fruticosa) CO2-se extract,Sage Triloba (syn. Fruticosa) CO2-se extract (organic), DE-ÖKO-013,Sage Triloba (syn. Fruticosa) CO2-to extract,Sage Triloba (syn. Fruticosa) CO2-to extract, 5 % Oleanolic/Ursolic acid,Sawpalmetto Berries CO2-to extract,Schisandra Fruit CO2-to extract, Variety Chinensis,Schisandra Fruit CO2-to extract, Variety Sphenanthera,Seabuckthorn Berries CO2-to extract,Seabuckthorn Berries CO2-to extract (organic), DE-ÖKO-013,Seabuckthorn Berries CO2-to extract (organic), DE-ÖKO-013,Seabuckthorn Berries CO2-to extract, (NOP-organic cert. by CERES),Seabuckthorn Pulp CO2-to extract,Seabuckthorn Pulp CO2-to extract (organic), DE-ÖKO-013,Seabuckthorn Pulp CO2-to extract (organic), semi-solid lipids, DE-ÖKO-013,Seabuckthorn Pulp CO2-to extract, < 0,1 % Carotenoides,Seabuckthorn Pulp CO2-to extract, semi-solid lipids,Seabuckthorn Seed CO2-to extract,Soy Germ CO2-to extract (organic), DE-ÖKO-013,St. John's Wort CO2-to extract,St. John's Wort CO2-to extract, 10 % Hyperforins,Star anise CO2-se extract,Star anise CO2-se extract (organic), DE-ÖKO-013,Tagetes Flower CO2-to extract,Thyme CO2-se extract,Thyme CO2-to extract,Usnea Lichen CO2-to extract, water dispersible, 4 % Usnic Acids,Vanilla Planifolia CO2-HA-extract, 2 % Vanillin,Vanilla Planifolia CO2-to extract (organic), 12 % Vanillin, DE-ÖKO-013,Vanilla Planifolia CO2-to extract (organic), 26 % Vanillin, DE-ÖKO-013,Vanilla Planifolia CO2-to extract (organic), 95 % Vanillin, DE-ÖKO-013,Vanilla Planifolia CO2-to extract, 12 % Vanillin,Vanilla Planifolia CO2-to extract, 26 % Vanillin,Vanilla Planifolia CO2-to extract, 95 % Vanillin,Vanilla Tahitensis CO2-to extract,Vanilla Tahitensis CO2-to extract, 60 % origin Tahiti,Wheat bran CO2-to extract (organic), DE-ÖKO-013,

2 route de remich Luxembourg Ellange, Choose a State, 5690 LuxembourgGeneCust offers gene synthesis, cloning, DNA array, peptide synthesis, and adenovirus services.

30b rue Dominique Lang L-3505 Dudelange LuxembourgGeneCust offers gene synthesis, cloning, DNA array, peptide synthesis, and adenovirus services.

14 Rue Charlemagne Luxembourg, Luxembourg, 1328 Luxembourg

41 Rue du Brill Sanem, Luxembourg, 4422 LuxembourgInvitrolize is a biotech company from Luxembourg that has developed ALIsens®, a patented human in vitro alveolar model that, for the first time, enables the identification and differentiation of respiratory sensitizers and irritants under realistic air–liquid interface exposure conditions.

JenLab GmbH Science Park 2 Campus D1.2 66123 Saarbrücken

L4-QLeiden University Medical Center offers research services in the fields of malaria, cellular immunology, glycobiology, and epidemiology.

Core Facility Cytometry CRP-Santé CHL Maternité Basement Rm 7 120, route d’Arlon L-1150 LuxembourgThe Flow Cytometry Competence Center (CFC) within the Luxembourg Biomedical Research Resources (LBR2) at CRP-Santé is a shared core resource facility that is available to assist researchers with flow cytometry experimental design, data acquisition, cell sorting, and data analysis. The CFC is an open facility accessible to all scientists at CRP-Santé as well as external researchers. The CFC is equipped with a state-of-the art FACSAria cell sorter and a FACSCanto analyzer. The CFC is available to provide the following expertise (additional flow cytometry techniques not listed here may be implemented upon request): Multicolor analysis, with a maximum of 17 parameters Cell sorting, including single cell sort with variable receptors Side population, apoptosis, and calcium flux detection Cytometry Beads Array (CBA) immunoassay Cell cycle studies Assistance with experimental design and data processing

22 Avenue Foch 54000 Nancy, FranceMerge Healthcare specializes in clinical systems and offers cloud-based solutions for imaging and data analytics.

Industriestr 1b Deutschland Überherrn, Saarland, 66802 GermanyMJR PHARMJET IS A PROVIDER OF ANALYTICAL AND FORMULATION DEVELOPMENT SERVICES FOR PHARMACEUTICALS WITH A SPECIAL FOCUS ON THE LOW SOLUBLE SUBSTANCES. WE ARE YOUR RELIABLE PARTNER FOR DEVELOPMENT OF ALL DOSAGE FORMS INCLUDING SOLID, LIQUID AND SEMI SOLIDS. MJR PHARMJET ENSURES SOLUTION FOR YOUR FORMULATION CHALLENGES WITH INNOVATIVE TECHNOLOGIES, WHERE WE COMBINE OUR EXPERTISE WITH HIGH QUALITY STANDARDS. THANKS TO OUR WIDE RANGE OF SERVICES WE ACCOMPANY THE WHOLE WAY FROM CONCEPTUAL APPROACH OVER DEVELOPMENT TO MANUFACTURING.

1 Industriestraße Überherrn, SL, 66802 GermanyMJR PHARMJET IS A PROVIDER OF ANALYTICAL AND FORMULATION DEVELOPMENT SERVICES FOR PHARMACEUTICALS WITH A SPECIAL FOCUS ON THE LOW SOLUBLE SUBSTANCES. WE ARE YOUR RELIABLE PARTNER FOR DEVELOPMENT OF ALL DOSAGE FORMS INCLUDING SOLID, LIQUID AND SEMI SOLIDS. MJR PHARMJET ENSURES SOLUTION FOR YOUR FORMULATION CHALLENGES WITH INNOVATIVE TECHNOLOGIES, WHERE WE COMBINE OUR EXPERTISE WITH HIGH QUALITY STANDARDS. THANKS TO OUR WIDE RANGE OF SERVICES WE ACCOMPANY THE WHOLE WAY FROM CONCEPTUAL APPROACH OVER DEVELOPMENT TO MANUFACTURING.

Industriestr 1b Überherrn, 66802 GermanyMyBiotech is a CDMO on the fields of Biotechnology and Pharmaceuticals. Biotechnological production is covered with all aspects of upstream and downstream processes focusing on cell disruption with our propriety technology and purification with chromatographic methods such as ion exchange and supercritical fluid chromatography. Biotechnological production of active pharmaceutical ingredients and natural substances is also one of the core aspects of our business. Our products include Algae derived Omega-3 fatty acids, innovative Omega-3 formulations Curcumin, Phycocyanin along with plant derived natural supplements. Pharmaceutical division is specialized on development and technology transfer of nanoparticle and microparticle formulations from concept through development all the way up to GMP manufacturing. We are continuously developing and adapting innovative production methods for GMP manufacturing and processing of particulate systems. We support you with our innovative technologies to bring your project one step closer to success.

Boulevard de la Moselle BP 50 - 54340 Pompey FRANCENovasep provides chiral separations, custom synthesis, manufacturing, generics development, and purification scale-up.

29 Rue Henri Koch Esch-sur-Alzette, 4354 LuxembourgOrganoTherapeutics has the mission to accelerate the development of therapeutics against neurodegeneration. We currently focus on Parkinson’s disease. Our team is convinced that therapeutics targeting complex human diseases - like Parkinson’s - need to be developed using complex human patient-specific models. Our team has developed PD patient-specific cell culture models, organoids and assembloids, that replicate the Parkinson’s pathology and, to an extent, that cannot be found in any other cell culture or animal model. The organoid and assembloid models are IP-protected and have been used in the past 6 years in joint projects with academic and industry partners from Europe, the USA and Japan.

Science Park 2, Saarbrücken, 66123 GermanyPharmacelsus is a GLP certified service provider for analytical services in the area of preclinical and clinical drug research and development and during ecotoxicological studies for chemicals and crop protection products. Pharmacelsus performs highest quality analyses of small molecules, therapeutic peptides, biomarkers and large molecules using latest technology and instrumentation. Furthermore, we conduct complete workflows for in vivo studies in rodents in house (in life part, bioanalysis, metabolite identification and DMPK evaluation). Our portfolio is completed by the performance of in vitro ADMET studies which support early and late research phases during drug development and “next generation” safety assessment studies for cosmetics and chemicals. Responding to our customers’ needs, flexibility in study design and meeting demanding time lines is the strength of the Pharmacelsus team!

1 rue Grandville Nancy, 54000 FrancePROGEPI - PROCESSlab is the centre for technology transfer of the LRGP (Reactions and Chemical Engineering Laboratory), located in ENSIC-Nancy. Since 2007, PROGEPI is integrated in the *ICEEL* institute (a national label given by ANR French Research National Agency) covering the Energy and Environment areas. Since its creation in 2005, PROGEPI has carried out about 600 studies for companies. We have a full-time team, an expertise of laboratories, as well as an access to their whole infrastructure (analytical equipment, test floors, documentation centre, computational equipment, mechanical workshop…).

4 rue Jean Pierre Brasseur Luxembourg, L-1258 LuxembourgPutnam, an Inizio Advisory company, is a leading scientific and strategic consulting partner that helps the global life science community make confident decisions, build value, and bring life-changing innovations to clinicians and patients. For more than 30 years, our rigorous, bespoke approach and globally diverse team have delivered unrivalled depth across therapeutic areas, business functions, geographic markets, health care sectors, and technology platforms to maximize the human impact and commercial success of client innovations. Bridging science & strategy our purpose is to help the global life science community make confident decisions, build value, and bring life-changing innovations to clinicians and patients. We’re serving all the top 20 global biopharmaceutical companies, small and mid-sized biopharmas, emerging biotechs, and private equity and venture capital firms. We operate under three main practice areas. - Value, Pricing & Access Practice Area (build value and navigate the payer landscape to drive patient access and commercial success): value, pricing & access strategy | HEOR evidence generation | evidence synthesis & RWE generation Combining rigorous science, payer, and health care system expertise, thorough strategic framing and analytics, and an ethos to pioneer, Putnam supports clients in evidence generation, HTA navigation, pricing and access strategy, payer and channel contracting, and distribution strategy. We deliver expertise across scientific and commercial domains, delivering a collaborative and bespoke approach to maximize patient access and the commercial success of client innovations. Complementary expertise from PHMR, SmartAnalyst and Creativ-Ceutical was brought together and are now part of Putnam VPA. - Commercial Practice Area (commercialize with confidence to create a real, lasting impact): portfolio, licensing & development | commercialization & growth | data strategy & analytics Putnam provides commercial advisory solutions across the product development and commercialization lifecycle. Grounded in scientific and strategic excellence and delivered by experts with deep therapeutic area expertise, our solutions help maximize the commercial success of your products and portfolio to ensure the greatest clinical impact to patients. - Medical & Scientific Affairs Practice Area (elevate the impact of your medical and scientific innovation): asset development | launch strategy |digital health & omnichannel strategy Putnam provides world-class thought partnership and solutions that enhance the business impact of medical and scientific affairs. Cantered on deep vertical expertise paired with a pioneering ethos and large-scale data capabilities, we support teams across a wide range of needs, including asset development, launch strategy, and digital health and omnichannel strategy. What sets us apart? - Scientific and strategic excellence - Rigorous, bespoke approach - Global life science experts In Putnam we believe, that to create real, lasting change on human health, we must bring out the best in our people, in every way and at every level. Both to our clients and to our employees, we offer a boutique-firm feel inside a global enterprise, opening the door to limitless opportunities.

Comotorstr. 2, Industriestr. 1B Deutschland Überherrn, Saarland, D-66802 GermanyQUASAAR: EFFICIENCY + INNOVATION = QUALITY Quasaar is your experienced and reliable partner for all aspects of product development, quality control, stability studies, analytical services, GMP-support and product optimization and product rescue. Our competences are focused on the highly regulated pharmaceutical and life science area (GMP). But healthcare, consumer care and food sectors also benefit from Quasaar's own service profile. A high level of experience in the regulated and technical environment as well as a comprehensive competence network guarantee high quality and constant innovation. We accompany you through the lifecycle of your product and support you with analytical services, clinical trials, market launch and long-term marketing of your product. On our campus in Überherrn we offer 5.000 sqm of ultramodern state-of-the-art laboratories, an innovative and large-volume stability center and a unique development area. There we will initially provide an inspiring and efficient work environment for up to 50 highly qualified employees. Through a tailor-made outsourcing concept, we are establishing ourselves as a top partner in the pharmaceutical and lifescience industry. We rely on long-term cooperation with our customers in order to successfully position their products on the market. Only the combination of motivated, competent employees, state-of-the-art equipment and new technologies makes this possible. Therefore, the most important goal is the sustained establishment and expansion of a highly qualified employee base. Our mission is to create a work environment characterized by a high degree of innovation and social strength. Together with our scientific partners and partner companies, we create structures and processes for the economic implementation of our activities. This allows the latest technologies to be tested and applied in a practical manner. In cooperation with our excellence partners, we also invest in process optimization and lean management. After all, quality is made possible only by efficient processes and innovative methods. Quality Control: Excipients / API / Finished Products Analytics and QC to the highest level – applied to finished pharmaceuticals, medicinal products, ingredients and excipients Stability/Ageing Studies: 500 m3 to 2000 m3 ICH-Climates Stability studies and climate storage projects in large variety Technology Transfer Methods transfer, risk analysis and robustness investigations, seamless transfer from development stages into the regulated GMP environment Optimization / Validation / Transfer of analytical Methods Many cutting edge – methods including when dealing with all kind of particulate systems GMP-Support: Qualification / Validation / Consulting GMP-consulting and training aligned to your daily work. Product Rescue: Re-formulation & Optimization Optimization and reformulation of critical formulations based on QC-meta-data or development data

132 Rue Andre Bisiaux Maxeville, 54320 FranceWhen renting medical devices at Quipment TM, you not only get your investigator sites equipped on time. You also get leading-edge tools to pilot your study equipment like never before. Quipment is setting new standards in equipment rental and management. With Quipsite®, the most integrated platform on the market, Quipment brings a unique technology that allows its customers to deploy and manage study equipment with unparalleled efficiency.

Campus A1.1 Saarbrücken, 66123 GermanySciVii Labs is a recently established GLP-certified contract research organisation that works closely with HIPS (Helmholtz Institute for Pharmaceutical Research in Saarland). Our team comprises highly specialised veterinarians and scientists, collectively offering a broad range of knowledge and extensive experience in pharmacology, toxicology, cell biology, analytics and regulatory requirements. We are pleased to offer services to pharmaceutical and chemical companies, particularly in the areas of in vivo efficacy and toxicity studies. Our core competencies in animal model quality, 3Rs animal welfare and model standardisation guarantee that you will receive the highest quality and most reliable models for your questions. We provide expert advice and comprehensive services throughout the entire process to support our customers. We assist with planning studies and carry out sampling (blood and tissue collection) according to high-quality standards. We can take over the analysis or, in close consultation with you, organise an analysis with a third-party provider. We also provide full documentation, compile results and prepare reports in co-operation with our clients.

Starterzentrum 1, Geb. A1 Saarbrücken, 66123 GermanySciVii Labs is a recently established GLP-certified contract research organisation that works closely with HIPS (Helmholtz Institute for Pharmaceutical Research in Saarland). Our team comprises highly specialised veterinarians and scientists, collectively offering a broad range of knowledge and extensive experience in pharmacology, toxicology, cell biology, analytics and regulatory requirements. We are pleased to offer services to pharmaceutical and chemical companies, particularly in the areas of in vivo efficacy and toxicity studies. Our core competencies in animal model quality, 3Rs animal welfare and model standardisation guarantee that you will receive the highest quality and most reliable models for your questions. We provide expert advice and comprehensive services throughout the entire process to support our customers. We assist with planning studies and carry out sampling (blood and tissue collection) according to high-quality standards. We can take over the analysis or, in close consultation with you, organise an analysis with a third-party provider. We also provide full documentation, compile results and prepare reports in co-operation with our clients.

Champigneulles, Grand Est FranceSeparex provides supercritical and high pressure technology applications and systems.

Institut Polytechnique National de Lorraine 2 avenue de la Forêt des Haye 54500 Vandœuvre-lès-Nancy, FranceProviding clients with acutely induced phenotypic models of proteopathic neurodegenerative diseases, accelerating drug discovery of symptomatic and disease-modifying therapeutics.

24-30, rue Lionnois 54000 Nancy, FranceProviding clients with acutely induced phenotypic models of proteopathic neurodegenerative diseases, accelerating drug discovery of symptomatic and disease-modifying therapeutics.

53 Boulevard Royal Luxembourg, Luxembourg, 2449 LuxembourgAt Ypso-Facto, we develop and optimize (bio)processes. We combine industrial experience and scientific expertise with a complementary know-how in (bio)chemistry, process engineering and software development to offer technology enabled services and proprietary software in upstream and downstream. We provide two complementary approaches: - Comprehensive software suite for the development, evaluation, and simulation of (bio)processes including: process modeling and simulation, data capture, data analysis, mass balances, techno-economic analysis - Scientific and technical consulting including: mechanistic modeling, simulation, and expertise for improving yield and productivity, reaching target performances, bringing process understanding and solving technical and scientific challenges.

19 Avenue Foch Nancy, Grand Est, 54000 FranceAt Ypso-Facto, we develop and optimize (bio)processes. We combine industrial experience and scientific expertise with a complementary know-how in (bio)chemistry, process engineering and software development to offer technology enabled services and proprietary software in upstream and downstream. We provide two complementary approaches: - Comprehensive software suite for the development, evaluation, and simulation of (bio)processes including: process modeling and simulation, data capture, data analysis, mass balances, techno-economic analysis - Scientific and technical consulting including: mechanistic modeling, simulation, and expertise for improving yield and productivity, reaching target performances, bringing process understanding and solving technical and scientific challenges.

2 Rue Josy Welter Walferdange, Luxembourg, 7256 LuxembourgAt Ypso-Facto, we develop and optimize (bio)processes. We combine industrial experience and scientific expertise with a complementary know-how in (bio)chemistry, process engineering and software development to offer technology enabled services and proprietary software in upstream and downstream. We provide two complementary approaches: - Comprehensive software suite for the development, evaluation, and simulation of (bio)processes including: process modeling and simulation, data capture, data analysis, mass balances, techno-economic analysis - Scientific and technical consulting including: mechanistic modeling, simulation, and expertise for improving yield and productivity, reaching target performances, bringing process understanding and solving technical and scientific challenges.