S-cube 104 130-42 Nagasone-cho Kita-ku Sakai-shi, 591-8025 JapanABsize offers formulation services for poorly water-soluble molecules without chemical charge.

10th Floor, The 3rd Fuji Bldg. 1-3-13 Itachibori, Nishi-ku, Osaka, 550-0012Acronet offers toxicology, safety pharmacology studies, virus validation, ADME, and phase I clinical trials.

6-7-6 Minatojima Minamimachi Chuo-ku Kobe 650-0047 JAPANAllied Laboratories provides customized CMC solutions for development phase Pharma project. We support supply chain management for semi-bulk scale API and intermediates required for development stage. Our consulting service covers all aspects of development issues such as regulatory compliance, development strategy, cGMP compliance, bridging medicinal chemistry to process chemistry with global network and experienced team. Allied Laboratories supports whole elements of CMC issues such as cGMP compliances, Analytical development, Process development and manufacturing strategy. Allied represents globally recognized NY based CMC consulting group Rondaxe Pharma Inc. in Japan. Well experienced and responsible Rondaxe team actively supports our client’s project to maximize efficiency from pre-clinical to commercial phase. Utilizing our own laboratory and extended laboratory alliance, we provide tailor made R&D services such as analytical support for imported APIs, preparation of small-scale samples, quality evaluation for customer’s R&D stage projects. Our chemistry is not limited into Pharmaceutical area but also supports specialty chemicals, chemicals for electronics or other advanced materials. Import and export unique lab and plant equipment is our another expertise. If commercial product doesn’t fit your application, we will design and manufacture custom made equipment or machine to fit your specific needs.

6F MF Nishi-Umeda Building 5-1-26 Fukushima, Fukushima-ku Osaka, 553-0003 JapanBBK Worldwide provides investigator and ptient recruitment services.

5-1-3 Miyahara, Yodogawa-ku, Osaka 532-0003, JapanFor 40 years since it founding, BoZo Research Center has undertaken contracts for pre-clinical research and toxicology. We have a long track record of providing excellent customer support in both rat and mice carcinogenicity studies and are proud to be one of Japan’s leading pre-clinical CROs. We take great care to provide our customers with a wide range of services, including tests on new animal species, alternative methods or bio-marker tests, as well as building up integrated support mechanisms to cover all stages of development from drug discovery through to pre-clinical studies. We aim to continue our contributions to a more affluent society by serving as a bridge linking the passion of researchers with the hopes of consumers. BoZo Research Center owns several facilities: The Gotemba and Kannami Laboratories for safety testing in both large and smal animals. The Tokyo Laboratory, one of Japan’s leading centers for genetic toxicity (AMES) tests The Tsukuba Research Institute which offers a wide range of services from the initial stages of development (pharmacology and analytical tests) to safety studies, in various species including miniature pigs.

1-10-27-5F, Edobori Nishi-ku Osaka 550-0002 JapanCLC Bio provides bioinformatics and sequencing services.

Kyoto, Kyoto Prefecture JapanCosMED Pharmaceuticals offers a range of transdermal delivery systems for nervous system disorder,anti-emetic, hormone therapy and other therapeutic areas.

448-5 Kajii-cyo Kamigyo-ku Kyoto 607-0841, JapanCosMED Pharmaceuticals offers a range of transdermal delivery systems for nervous system disorder,anti-emetic, hormone therapy and other therapeutic areas.

Osaka, Osaka Prefecture JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

Mainichi Intecio., 4-5, Umeda 3-chome, Kita-ku, Osaka 530-0001, JapanDaicel Chemical Industries offers API, chiral chromatographic separation, and synthesis services.

Minatojima-minamimachi 5-5-2, Chuo-ku Kobe, 650-0047, JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

1-4-29 Kunijima Higashi-Yodogawa-ku, Osaka 533-0024 JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

Yodogawa Ward, Osaka Prefecture JapanHamari Chemicals is specialized in the manufacture of APIs and pharmaceutical intermediates, food additives, amino acid derivatives, nutritional ingredients, peptide, cosmetic substances, dietary supplements

Osaka, JapanHokkaido System Science provides DNA, microarray, protein, and gene related services

2, Miyanohigashi, Kisshoin Minami-Ku, Kyoto 601-8510 JapanHORIBA provides an extensive array of instruments and systems for applications ranging from automotive R&D, process and environmental monitoring, in-vitro medical diagnostics, semiconductor manufacturing and metrology, to a broad range of scientific R&D and QC measurements.

Nishiwaki, JapanInCROM offers clinical research services including first in human studies, PK/PD studies, and data management.

3-5-7 Kawara-machi Osaka, Osaka, 542-0076 JapanINTAGE Healthcare is a leading healthcare marketing intelligence and evidence provider headquartered in Japan. We provide comprehensive pre-launch and post-launch support to meet the full range of healthcare information needs through real-world data analytics, post-marketing surveillance, and marketing research. We combine our deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

5-16-26 Minami-Suita, Suita, Osaka 564-0043, JapanJCL Bioassay USA is a highly dedicated and responsive bioanalytical Contract Research Organization (CRO) for small and large molecule bioanalysis. We partner with our clients throughout the discovery and development process to identify and develop life-changing therapies. With JCL, you can trust that you will receive reliable and timely assay results so you can make informed drug development decisions.

17-18 Nakahata-cho, Nishiwaki, Hyogo 677-0032, JapanJCL Bioassay USA is a highly dedicated and responsive bioanalytical Contract Research Organization (CRO) for small and large molecule bioanalysis. We partner with our clients throughout the discovery and development process to identify and develop life-changing therapies. With JCL, you can trust that you will receive reliable and timely assay results so you can make informed drug development decisions.

7-6-8 Saito-Asagi, Ibaraki Osaka 567-0085, JAPANJCRB Cell Bank (Japanese Collection of Research Bioresources Cell Bank) supplies and distributes cell lines and tissues.

2-1-20, kukuchi Nishimach Amagasaki-shi, Hyogo, 661-0978 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

Nishinokyo Nishigekkocho 40 Nakagyo-ku Kyoto-shi, Kyoto, 604-8423 JapanKAC is committed to make contributions to the advancement of sciences and the promotion of human welfare. KAC provide Laboratory Reagents and Materials for Bioresearch. https://www.saibou.jp/en/reagents/ Block Ace powder: Block Ace powder is prepared from milk protein and is a novel blocking agent for immunology experiments. Since milk protein contains many hydrophobic groups, it shows high affinity to plastic and membrane filters. Therefore, compared with conventional blocking agents such as bovine serum albumin (BSA), it is suitable for blocking nonspecific binding of antigens or antibodies when conducting Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA) and an immunoblotting method. https://www.saibou.jp/en/reagents/related/block_ace/ Mycoplasma removal agent (MC-210): Mycoplasma removal agent (MC-210) is a mycoplasma removal agent for cell culture and protects precious cultured cells for research from mycoplasma contamination. This agent demonstrates high removal effects against a common contaminant, i.e., mycoplasma orale. https://www.saibou.jp/en/reagents/related/mc210/ TC Protector: TC protector is a cell cryoprotective agent that does not contain any animal-derived components nor proteins and is chemically defined. It can be used in cells requiring serum addition, those without serum, and cells without proteins.It is suitable for cell line cells and normal cells as well as ES cells, adult stem cells, and human iPS cells. It is not viscous and does not form bubbles. Thus, it is excellent in usability. https://www.saibou.jp/en/reagents/related/tcp/

53-6 Jinbo, Koka-cho Koka City, Shiga, 520-3404 Japan

4-31, 2-chome, Kyutaro-machi Chuo-ku, Osaka 541-8581 JapanKURABO supplies various laboratory instruments and reagents for assays and cell culture while offering custom peptide synthesis, antibody production, and microarray analysis services.

53 Kawahara-cho, Shogoin, Sakyo-ku Kyoto , 606-8507 JapanTo serve as the world-first core institute dedicated to leading iPS cell research.

10F, Shin-Osaka Brick Bldg, 6-1 Miyahara 1-chome, Yodogawa-ku Osaka, Japan, 532-0003 JapanLinical is a public, mid-sized Contract Research Organization headquartered in Japan with a significant presence across all major markets including North America, Europe, and Asia-Pacific. Linical provides the full spectrum of drug development services from early stage to large-scale, multinational studies. Our areas of focus include Phase I-IV studies in oncology, neurology & psychiatry, immunology & vaccine, and endocrinology & metabolic diseases.

10F, Shin-Osaka Brick Bldg, 6-1 Miyahara 1-chome, Yodogawa-ku Osaka, 532-0003 JapanLinical is a public, mid-sized Contract Research Organization headquartered in Japan with a significant presence across all major markets including North America, Europe, and Asia-Pacific. Linical provides the full spectrum of drug development services from early stage to large-scale, multinational studies. Our areas of focus include Phase I-IV studies in oncology, neurology & psychiatry, immunology & vaccine, and endocrinology & metabolic diseases.

Kyoto-University Katsura Venture Plaza 1-36 Goryo-Ohara Nishikyo, Kyoto, 615-8425 JapanMiCAN technologies has developed a standardized and ready-to-use human dendritic cells from iPSC for various assays or developing therapeutics/vaccines.

7-7-20 Asagi,Saito Ibaraki city, osaka, 567-0085 Japanmass spectrometry imaging service We, Miruion CO., LTD., are a venture company established by Osaka University that provides total solutions related to "mass spectrometry imaging," an innovative analysis method that makes unknown distributions known. The most critical step that determines the results of an analysis is sample preparation. Dr. Shimma, who is our CTO, has performed over 1000 pretreatments over the past 15 years. Make use of the abundant know-how to carry out the optimum pretreatment for the properties of the sample. In addition, we offer consulting services for analysis of various samples and interpretation of analysis data, depending on the customer's needs. Please feel free to contact us for samples that are difficult to analyze elsewhere. It is possible to perform MSI of all substances such as plants, insects, foods as well as animal cells. Of course, analysis of cosmetics using 3D skin model can also be performed.

Senri Life Science Center Bldg.17F 1-4-2 Shinsenri Higashimachi, Toyonaka Osaka, 560-0082 JapanSince its foundation in 1970, Nagano Science has become the largest provider of services and products for pharmaceutical storage stability testing in Japan. Today all top ten pharmaceutical manufacturers and contract research organizations (CROs) in Japan trust Nagano Science products and services. More than 80% of all Japanese pharmaceutical companies are using our products and services. In addition to storage stability testing chambers, we also provide off-site stability storage space for pharmaceutical products to conduct ICH and GMP compliant storage stability testing. Our facility fulfils all criteria to international inspection and auditing requirements. Using Nagano Science for sample storage results in substantial cost-savings compared to investing in owned storage chambers and related space and / or equipment.

1-1-17 Shinmachi, Nishi-ku, Osaka City, Osaka 550-8668, JapanNagase provides resins, enzymes, antibodies, screening, gene expression, and silicone materials.

Nippon Seika Building 4-9 Bingomachi 2-chome, Chuo-ku, Osaka 541-0051 JapanNippon Fine Chemical offers manufacturing of fine chemicals, cosmetic products and industrial chemical products.

Kogin Bldg., 4-1-1 Koraibashi, Chuo-ku Osaka, 541-0043 JapanNIPPON SHOKUBAI is a Japan based CDMO for oligonucleotide and peptide. In addition to wide range of API manufacturing scale, we offer one-stop shop service to accelerate clients' project. As a provider of both technical and logistical solutions, NIPPON SHOKUBAI use our experience and connections to help our clients accelerate their R&D activities and develop effective manufacturing strategies: - Supporting development & commercialization for oligonucleotide and peptide APIs. - Leveraging technology to drive next-generation drug discovery modalities. We have established a system suitable for exploratory research to clinical trials, which enables us to offer a variety of solutions: - Small-scale synthesis for drug efficacy and toxicity evaluation in the drug discovery stage - Contract research on process and testing methods for pilot manufacturing - GMP-compliant API manufacturing for clinical trials Also, we offer a variety of manufacturing scales ranging from a few mg in the exploratory research stage to kg in the late clinical stage. NIPPON SHOKUBAI is a Japanese chemical company which has world-class production capacity of superabsorbent polymer and has supplied many valuable products with its unique organic synthesis technology. We've made successful advancements in health & medicine field by integrating new and conventional technologies. With a wealth of expertise in the development of investigational and commercial drugs, we are now the partner of choice for biotech and pharmaceutical companies.

5-8 Nishi Otabi-cho, Suita Osaka, 564-0034 JapanNIPPON SHOKUBAI is a Japan based CDMO for oligonucleotide and peptide. In addition to wide range of API manufacturing scale, we offer one-stop shop service to accelerate clients' project. As a provider of both technical and logistical solutions, NIPPON SHOKUBAI use our experience and connections to help our clients accelerate their R&D activities and develop effective manufacturing strategies: - Supporting development & commercialization for oligonucleotide and peptide APIs. - Leveraging technology to drive next-generation drug discovery modalities. We have established a system suitable for exploratory research to clinical trials, which enables us to offer a variety of solutions: - Small-scale synthesis for drug efficacy and toxicity evaluation in the drug discovery stage - Contract research on process and testing methods for pilot manufacturing - GMP-compliant API manufacturing for clinical trials Also, we offer a variety of manufacturing scales ranging from a few mg in the exploratory research stage to kg in the late clinical stage. NIPPON SHOKUBAI is a Japanese chemical company which has world-class production capacity of superabsorbent polymer and has supplied many valuable products with its unique organic synthesis technology. We've made successful advancements in health & medicine field by integrating new and conventional technologies. With a wealth of expertise in the development of investigational and commercial drugs, we are now the partner of choice for biotech and pharmaceutical companies.

UKAWA555 MINAKUCHI KOKA, SHIGA, 528-0052 JapanNISSEI BILIS CO., LTD. is the preclinical CRO in Koka-city, Shiga, Japan. Since established in 1973, we have studied on variety of modalities, such as pharmaceuticals, medical devices and regenerative medicine products.Particularly, we specialize in the pharmacology study, and we established many disease models induced by drugs or surgical operation for studying such these diseases. Although the numbers of employees are approximately 60 and the scale is small as CRO, we have high technical skills.You will be satisfied our attentive service that the large-scale CRO could not handle.

1-1-2, Shimohozumi, Ibaraki, Osaka, 567-8680 JapanNitto is a high-performance materials manufacturer. Since its founding in 1918, it has been providing a wide range of products and services globally. These include optical materials such as polarizing films used in display devices, circuit boards, industrial tapes, and medical-related products, all developed based on its eight core technologies. Guided by the brand slogan “Innovation for Customers,” Nitto strives to create essential values for the world and contribute to a sustainable global environment and a prosperous human society.

1-1-33, Sumiyoshihigashi-machi, Higashinada-ku, Kobe, Hyogo, 658-0052, JapanNoveltec supports study in disease animal models through software and examination systems.

Higashiosaka, Osaka Prefecture, 577-0066 JapanOsaka Seiyaku manufactures and sells pharmaceuticals, quasi drugs, hygiene products and cosmetics.

No. 4, No. 2, 3-chome, Higashi-Osaka Takaidahondori, JapanOsaka Seiyaku manufactures and sells pharmaceuticals, quasi drugs, hygiene products and cosmetics.

Yamadaoka 2-2, Suita, Osaka, JapanOsaka University Department of Ophthalmology focuses on research in the field of ocular disease.

Osaka, Osaka Prefecture JapanOsaka University Department of Ophthalmology focuses on research in the field of ocular disease.

2nd Fl. IFReC Research Building, Osaka University 3-1 Yamadaoka, Suita, 565-0871, Osaka, JapanOsaka University Immunology Frontier Research Center (IFReC), directed by Prof. Shizuo Akira, was selected by the Japanese Ministry of Education, Culture, Sports, Science, and Technology as one of the nation's five exclusive World Premier International (WPI) Research Centers. Since the WPI program was established in 2007, IFReC has engaged in high-level research that is expected to make it an internationally renowned research center in the field of immunology. Immunology explores the mechanisms that protect the body against various pathogens such as bacteria and viruses. Because the immune system is essential for eliminating infectious pathogens from the body, its malfunction gives rise to various immune disorders including allergies, cancers, autoimmune diseases, and allograft rejection during transplantation. The scientific aim of IFReC is to contribute to a more comprehensive understanding of the dynamics of the immune system by employing not only traditional immunology experiments, but also a variety of imaging and bioinformatics technologies. In order to accomplish this goal, IFReC has recruited a diverse team of imaging and informatics scientists. These efforts will enable immunologists to directly track the dynamic behavior of immune cells and their cell-to-cell networks in order to clarify how immune cells respond to pathogens and cancers in vivo.

2nd Fl. IFReC Research Building, Osaka University 3-1 Yamadaoka, Suita Osaka, 565-0871 JapanOsaka University Immunology Frontier Research Center (IFReC), directed by Prof. Shizuo Akira, was selected by the Japanese Ministry of Education, Culture, Sports, Science, and Technology as one of the nation's five exclusive World Premier International (WPI) Research Centers. Since the WPI program was established in 2007, IFReC has engaged in high-level research that is expected to make it an internationally renowned research center in the field of immunology. Immunology explores the mechanisms that protect the body against various pathogens such as bacteria and viruses. Because the immune system is essential for eliminating infectious pathogens from the body, its malfunction gives rise to various immune disorders including allergies, cancers, autoimmune diseases, and allograft rejection during transplantation. The scientific aim of IFReC is to contribute to a more comprehensive understanding of the dynamics of the immune system by employing not only traditional immunology experiments, but also a variety of imaging and bioinformatics technologies. In order to accomplish this goal, IFReC has recruited a diverse team of imaging and informatics scientists. These efforts will enable immunologists to directly track the dynamic behavior of immune cells and their cell-to-cell networks in order to clarify how immune cells respond to pathogens and cancers in vivo.

6-104 Majima Fukuju-cho, Hashima City, Gifu, 501-6251 JapanOYC Americas is committed to supporting human healthcare innovation within the clinical diagnostic, pharmaceutical, nutraceutical, food, and functional food industries through the marketing of yeast fermentation and distribution of its by-products. Our goal is to provide value to research & development, manufacturing, and marketing by supplying unique raw materials, food ingredients, and ingredient technologies developed by our parent company, Oriental Yeast Co., Ltd. of Japan and their associated partnerships. We strive to meet the regulatory demands of the human health and nutrition industry with products developed through scientific research and clinical support. Our business partnerships are earned and maintained through our long-term commitment to quality, service, and dedication to the science of human health.

2-5-1, Mishima Settsu, Osaka, 566-0022 JapanContract Development and Manufacturing Organization for peptides and oligonucleotides

大阪府箕面市如意谷4-6-9-704 大阪, 5620011 Japan

大阪府茨木市彩都あさぎ7－6－8 大阪, 567-0085 Japan

Kyoto, Kyoto, 602-8482 JapanReal World Data co., Ltd. deals with RWD database. RWD database has over 19 million patients from 170 medical faculties in Japan. RWD database is the only database in Japan that contains electronic medical record(EMR) data source. We supply the data and its analytics that represents Japanese medical situation.

5F, G-4(A-7), ATC Bldg, ITM Mune, Nankou-Kita2-1-10, Suminoe-Ku, Osaka, JapanRUNDO-CRONOVA offers clinical trial management, statistics services, regulatory affairs, and consulting.

Kyoto, JapanSanyo Chemical Industries, Ltd. manufactures and sells chemical products in Japan and internationally. The company offers superabsorbent polymers, surfactants for hair care products and detergents, base materials for cosmetics and pharmaceuticals, antibacterial agents, EIA diagnostic reagents, potting resins for artificial kidneys, pressure-sensitive adhesives, and hot melt adhesives; and raw materials for polyurethane foam, polyurethane beads for powder slush molding, lubricating oil and fuel oil additives, base materials for synthetic lubricants, water-soluble cutting fluids, halogen-free cleaning agents, and paste resin for design models. It also provides agents for synthetic fiber production and fiberglass, chemicals for carbon fibers, polyurethane for artificial/synthetic leather production and precision grinding, and modifiers for synthetic fibers; and intermediates for polymerization toners/toner resins, electrolytes for aluminum electrolytic and electric double-layer capacitors, cleaning agents for hard disks manufacturing process, processing agents for semiconductors, and photo-acid generators. In addition, the company offers polymer flocculants for industrial wastewater treatment, polyurethane for heat insulating materials, slurry agents, coat-type permeable waterproof material, and reactive hot-melt adhesives; and permanent antistatic agents, pigment dispersants, resin and rheology modifiers, UV/EB curing resins, base materials for polyurethane elastomer, paint resins, defoaming agents, chemical boards for models, emulsifiers for emulsion polymerization, epoxy resin curing agents and accelerators, and polyurethane catalysts. Further, it is involved in general trucking, insurance and travel agency, and real estate businesses; and sells living ware products. The company was formerly known as Sanyo Chemical Industry Co. and changed its name to Sanyo Chemical Industries, Ltd. in 1966. The company was founded in 1949 and is headquartered in Kyoto, Japan.

Kannonji Kashihara City, Nara Prefecture 〒 634-8567 JapanSATO YAKUHIN KOGYO offers contract pharmaceutical proessing, over-the-counter medication, bulk pharmaceuticals, medicinal products and ethical drugs.

2-5-8,Hirano-machi Chuo-ku, Osaka JapanThe characters that comprise Senju's company name in the Japanese language are "千(Sen)" and "寿(Ju)" which literally mean "thousand" and "bringing happiness", respectively. Senju, bringing much (a thousand) happiness, has an objective that we bring a "happiness" to the people associated with Senju through the development of original pharmaceutical products for the care of the five senses (eye, ear, nose, throat and skin), that improve the joy of living. This is our management principle, "Good Company". Furthermore, we strongly believe that Senju should be a trustworthy and essential company by putting ourselves into the other person's shoes and acting under the company concept of "If I were you".

, Chūō-ku, Ōsaka-fu 541-0046, JPThe characters that comprise Senju's company name in the Japanese language are "千(Sen)" and "寿(Ju)" which literally mean "thousand" and "bringing happiness", respectively. Senju, bringing much (a thousand) happiness, has an objective that we bring a "happiness" to the people associated with Senju through the development of original pharmaceutical products for the care of the five senses (eye, ear, nose, throat and skin), that improve the joy of living. This is our management principle, "Good Company". Furthermore, we strongly believe that Senju should be a trustworthy and essential company by putting ourselves into the other person's shoes and acting under the company concept of "If I were you".

, Chūō-ku, Ōsaka-fu 541-0045, JPUnder our Company Policy to "supply the best possible medicine to protect the health and wellbeing of the patients we serve," it is our mission as the Shionogi Group to deliver medical products creating a higher level of satisfaction to patients and their families for improved quality of life (QOL). To achieve this goal, we are constantly engaged in the research, development, manufacturing, and marketing activities of medical products, with a focus on prescription drugs. In fulfill our goal, we have set out the following Shionogi efforts: Venture into the field of cutting-edge medical technologies and be active as a research-driven pharmaceutical company. Establish production systems that ensure a stable supply of high-quality products that can be used with confidence. Provide in a timely and accurate manner, through healthcare providers, the information necessary to use our products appropriately. To further serve patients worldwide, we carry out these activities domestically and globally and are committed to making our business efforts to expand our business more actively. Meanwhile, Shionogi is also aware of how essential compliance in business activities is in the light of ensuring the sustainability and advancement of the company itself. We are thoroughly devoted to the ethical conduct required for an enterprise and a member of society, not to mention complying with laws and regulations. In addition, to ensure fair and efficient management, Shionogi has structured a highly operational framework and systems that allow for a swift response to changes in the management environment. As members of the Shionogi Group spread across the globe, we are committed to maintaining high ethical standards and transparency as we face all challenges head on. Through these efforts, we aim to be a company that is trusted by all stakeholders, including shareholders, business partners, and society, as well as patients, their families, and healthcare providers. We also pursue to stay a company where all employees can take on challenges with pride and a strong sense of purpose. We would like to thank you for your interest in our company and our products and your continued support will be greatly appreciated.

1-8, Doshomachi 3-chome Chuo-ku, Osaka, 541-0045 JapanUnder our Company Policy to "supply the best possible medicine to protect the health and wellbeing of the patients we serve," it is our mission as the Shionogi Group to deliver medical products creating a higher level of satisfaction to patients and their families for improved quality of life (QOL). To achieve this goal, we are constantly engaged in the research, development, manufacturing, and marketing activities of medical products, with a focus on prescription drugs. In fulfill our goal, we have set out the following Shionogi efforts: Venture into the field of cutting-edge medical technologies and be active as a research-driven pharmaceutical company. Establish production systems that ensure a stable supply of high-quality products that can be used with confidence. Provide in a timely and accurate manner, through healthcare providers, the information necessary to use our products appropriately. To further serve patients worldwide, we carry out these activities domestically and globally and are committed to making our business efforts to expand our business more actively. Meanwhile, Shionogi is also aware of how essential compliance in business activities is in the light of ensuring the sustainability and advancement of the company itself. We are thoroughly devoted to the ethical conduct required for an enterprise and a member of society, not to mention complying with laws and regulations. In addition, to ensure fair and efficient management, Shionogi has structured a highly operational framework and systems that allow for a swift response to changes in the management environment. As members of the Shionogi Group spread across the globe, we are committed to maintaining high ethical standards and transparency as we face all challenges head on. Through these efforts, we aim to be a company that is trusted by all stakeholders, including shareholders, business partners, and society, as well as patients, their families, and healthcare providers. We also pursue to stay a company where all employees can take on challenges with pride and a strong sense of purpose. We would like to thank you for your interest in our company and our products and your continued support will be greatly appreciated.

1-135, Kasugade-Naka 3-chome, Konohana-ku, Osaka 554-0022, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Sumika Fudosan Yokobori Building, 6-17, Koraibashi 4-chome, Chuo-ku, Osaka, 541-0043, JapanSumika Chemical Analysis Service (SCAS) provides regulatory services, REACH consulting, chemical registration, and MSDS services.

Osaka, Osaka Prefecture JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

The Sumitomo Building 4-5-33 Kitahama, Chuo-ku, Osaka 541-0041, JapanSumitomo Seika offers absorbent polymers, functional chemicals, fine chemicals, gases and engineering.

1-Chome, Nishi-KU Kōbe-shi, Hyōgo-ken, 651-2241 JapanSysmex Inostics, a subsidiary of Sysmex Corporation, is a global leader in liquid biopsy clinical testing committed to improving the lives of patients with cancer. Our pioneering technologies, such as the gold-standard OncoBEAM (BEAMing) digital PCR and NGS-based SafeSEQ, deliver unparalleled high sensitivity for detection of tumor molecular alterations in blood and other sample types. We are a trusted partner to leading pharmaceutical companies, advancing their efforts to bring the most effective personalized cancer therapies and solutions to global markets. Sysmex Inostics´ three main areas of focus are: • BioPharma liquid biopsy testing & services • CDx/IVD development • Patient testing services (US only) Our Capabilities: • Custom Biomarker Assay Development • Global footprint of GCP/CLIA certified laboratories • Analytical and Clinical Validation • Global Regulatory Registration/Approval • cGMP Manufacturing • Full Service Clinical Trial Project Management • Companion Diagnostic (CDx) Kit Development and Commercialization

Ibaraki-shi, Ōsaka-fu, 567-0054 JapanTaisei Kako Co., Ltd manufactures the products made by some materials such as plastic, aluminum, glass for Pharmaceutical product, Medical products and Cosmetic products.

180 Umekoji, Inokuma, Shimogyo-ku,Kyoto, 600-8686, JapanTakii was established in 1835, starting as a seed store, dealing seeds of local Kyoto vegetable. Mr. Jisaburo Takii who was known as a hardworking and reliable farmer, started to produce and to distribute quality seed, which was the very beginning of Takii. Kyoto was an old capital and various kinds of vegetables from other areas were gathered and presented to the Imperial family and for many head’s of temples. Thus Kyoto has become one of the cradles of seed industry in Japan. In 1920, Takii started to export seed overseas, and after 1926 established its International Division. After WWII, Takii has been developing quality seed, creating new distribution networks and new ways of promotion, causing it to be recognized as one of the leading companies in the seed industry.

600-8686 JapanTakii was established in 1835, starting as a seed store, dealing seeds of local Kyoto vegetable. Mr. Jisaburo Takii who was known as a hardworking and reliable farmer, started to produce and to distribute quality seed, which was the very beginning of Takii. Kyoto was an old capital and various kinds of vegetables from other areas were gathered and presented to the Imperial family and for many head’s of temples. Thus Kyoto has become one of the cradles of seed industry in Japan. In 1920, Takii started to export seed overseas, and after 1926 established its International Division. After WWII, Takii has been developing quality seed, creating new distribution networks and new ways of promotion, causing it to be recognized as one of the leading companies in the seed industry.

4-1 Fushimimachi 4-chome, Chuo-ku, Osaka 541-0044, JapanTeikoku Seiyaku offers development, manufacturing and sales of medicated and medically related supplies.

4-4-9, Kouraibashi, Chuo-ku, Osaka 541-0043, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

1-8, Kasumi, Yokkaichi, Mie 510-8540, JapanTosoh offers ceramic materials, fine chemicals, fluoro compounds, organic intermediates, and polymer products and services.

Lab 1 Science Road Osaka, Oasaka, 12345 JapanTriage Pharmaceuticals is the industry leading global biotechnology organization across the Best Service Ever categories, operating in over 50 facilitates operating in over 15 countries. Our expert team is passionate about our role in building comprehensive _world-class_ solutions that best enables Triage to improve and expedite your pipeline - with laser focus on customer service and delivering results. Our service portfolio includes the earliest stages of drug discovery through clinical trials, and our philosophy is to be a trusted partner with you and your organization to determine the optimal solutions based on your objectives and KPIs. We are the world's leading premier CRO, and fully accredited in a variety of scientific disciplines. Our expertise include: * Next Generation Sequencing * Human Biological Sample Provisioning and Analysis

1-8-34 Oyodonaka, Kita-kuTrimGen specializes in developing innovative molecular assays to provide laboratories with advanced, cost effective tests and services. Using proprietary technologies, we offer unique assays for FFPE tissue DNA/RNA extraction as well as highly sensitive mutation and pathogen detection. Our STA technology has been widely applied to detect multiple mutations in the EGFR pathway including KRAS, BRAF, PIK3CA and other oncogenic mutations.

Nomura-fudosan Yotsubashi Bldg. 8F 1-4-4 Awaza Nishi-ku, Osaka-shi Osaka-fu 550-0011 JapanWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.