121 Royal Road Keokuk, IA, 52632 United States

2711 S. Loop Dr, Suite 4150 Ames, IA 50010 USAAdvanced Analytical Technologies offers analytical systems in application of analysis of pKa, log P, chiral compounds, oligonucleotide purity, protein separation, nucleic acids, and carbohydrates.

1615 Golden Aspen Drive, Suite 101 Ames IA 50010BioForce Nanosciences provides nanotech tools and services for surface patterning applications such as stem cell differentiation and neural cell guidance assays.

Ames, IA United StatesBioForce Nanosciences provides nanotech tools and services for surface patterning applications such as stem cell differentiation and neural cell guidance assays.

2500 Crosspark Rd W150 Coralville, IA, 52241 United StatesBio::Neos is a technology partner providing full-service custom software development for industrial scientists, healthcare providers, and others creating life-enhancing innovations. As a technology partner, we work with you to fully understand your science and the needed areas of improvement. With the power of collaboration, we can build intuitive platforms that allow science to speak for itself. Together we bridge the gap between science and technology, allowing you to focus on more discoveries and changing the world. We offer a free - no commitment, initial conversation to assess your needs and the solutions we can provide. Feel free to reach out through the contact form on our website or email: info@bioneos.com

323 W. Cherry Street North Liberty IA 52317 USABio-Research Products offers protein purification, characterization, diagnostic reagent components, enzyme production, and contract manufacturing.

North Liberty, IA, 52317 United StatesBio-Research Products offers protein purification, characterization, diagnostic reagent components, enzyme production, and contract manufacturing.

Iowa, 200 Trails Road Eldridge, IA 52748t ChemTreat, we understand that success is centered on demonstrating reliability and earning trust. When customers purchase our products, they’re really buying the peace of mind that comes with knowing a seasoned ChemTreat field engineer has everything under control.

Coralville, IA, USACenter for Biocatalysis and Bioprocessing provides contract fermentation, bioprocessing, and bulk biopharmaceuticals.

2501 Crosspark Road, MTF-Suite C100 Coralville, IA 52241 United States, North AmericaCenter for Biocatalysis and Bioprocessing provides contract fermentation, bioprocessing, and bulk biopharmaceuticals.

Center for Biocatalysis and Bioprocessing The University of Iowa University of Iowa Research Park 2501 Crosspark Road-Suite C100 Coralville, Iowa, 52241-3210 United StatesCenter for Biocatalysis and Bioprocessing provides contract fermentation, bioprocessing, and bulk biopharmaceuticals.

2501 Crosspark Rd. Suite B105 Coralville, IA 52241Cellular Engineering Technologies offers stem cell research, tissue engineering, preclinical drug discovery, and high throughput drug screening.

1205 11th Street Charles City, IA 50616 USACambrex offers a range of specialist drug substance technologies and capabilities including biocatalysis, continuous flow, controlled substances, solid state science, material characterization and highly potent APIs. In addition, Cambrex can support conventional dosage forms including oral solids, semi-solids and liquids and has the expertise to manufacture specialist dosage forms such as modified-release, fixed dose combination, pediatric, bi-layer tablets, stick packs, topicals, controlled substances, sterile and non-sterile ointments.

2865 Stoner Court North Liberty, IA 52317-9157 USACompleWare Corporation provides clinical research services, ECG, spirometry, and monitoring.

838 1st Street NW P.O. Box 74570 Cedar Rapids, IA 52407-4570 USADiamond V is recognized throughout the animal nutrition field as the innovative, scientifically motivated supplier of nutritional fermentation products and feed ingredients.

2507 University Ave. Des Moines, IA 50311

1000 41st Avenue Drive S.W. Cedar Rapids, IA 52404 USADuPont Industrial Biosciences provides products to agricultural, biotechnology, chemical and material science industries.

3200 Grand Ave Des Moines, IA 50312Our Mission To improve lives in our global community by educating diverse groups of highly competent and compassionate osteopathic physicians, health educators, researchers and scholars. Our Vision The College of Osteopathic Medicine will be a leader in innovative medical education, both undergraduate and graduate, by meeting the highest standards of academic and clinical achievement. The College of Osteopathic Medicine will be a cultivator of distinctive educators and students who discover, disseminate, and apply new knowledge. The College of Osteopathic Medicine, through innovative design, will develop methods/processes to educate our students in the pursuit of delivering services that enhance health, wellness and education in our local, national, and global communities. The College of Osteopathic Medicine will engage in and enable research and scholarly activity to advance the knowledge of health care, osteopathic medicine and in the sciences and technologies that will shape medicine, science, and education. The College of Osteopathic Medicine will encourage, enable, and enhance the creation and development of graduate medical education, by lending support, education, and resources to further the goal of creating graduate opportunities in osteopathic medicine.

3200 Grand Ave Des Moines, IA, 50312 United StatesOur Mission To improve lives in our global community by educating diverse groups of highly competent and compassionate osteopathic physicians, health educators, researchers and scholars. Our Vision The College of Osteopathic Medicine will be a leader in innovative medical education, both undergraduate and graduate, by meeting the highest standards of academic and clinical achievement. The College of Osteopathic Medicine will be a cultivator of distinctive educators and students who discover, disseminate, and apply new knowledge. The College of Osteopathic Medicine, through innovative design, will develop methods/processes to educate our students in the pursuit of delivering services that enhance health, wellness and education in our local, national, and global communities. The College of Osteopathic Medicine will engage in and enable research and scholarly activity to advance the knowledge of health care, osteopathic medicine and in the sciences and technologies that will shape medicine, science, and education. The College of Osteopathic Medicine will encourage, enable, and enhance the creation and development of graduate medical education, by lending support, education, and resources to further the goal of creating graduate opportunities in osteopathic medicine.

800 New York Ave. • Des Moines, IA 50313Des Moines Cold Storage is one of the Midwest's largest and most respected refrigeration and processing companies. Our reputation and experience come from over 100 years of serving our clients' precise business needs. Of course, over the past century we’ve learned a lot about keeping our customers satisfied. While our most basic services involve only the simple refrigeration, freezing, and storage of your products in our custom-built warehouses, our team at Des Moines Cold Storage prides itself on our specially crafted service packages. In the modern world of complex logistics and precise timetables, there are no two clients whose needs are exactly the same. These companies often have to choose from large service packages that either don't meet all their needs or require them to buy services they won't use. Not at Des Moines Cold Storage. We precisely tailor our services to meet the needs of our customers with a high level of efficiency, safety, and timeliness. Going even beyond that, we are able to maintain and train any specialized workforce that might be needed, as well as training for and operating of any specialty equipment. Coupled with our highly accessible and ideally located warehouses, there are no logistical needs we can't fill. In short, you get exactly what you need, when you need it. Over the last 100 years, Des Moines Cold Storage has built its unparalleled reputation on a set of core values that we refuse to compromise. These values represent the soul of what it is that we do here at Des Moines Cold Storage and the kind of consideration we give to every product in our warehouses. We are proud of our level of service and experience in this industry and are committed to bringing this service and experience into every facet of our customer-side interactions.

2811 Mt. Pleasant Street Burlington, IA 52601 USADoran & Ward Printing provide printing and packaging services.

West Burlington, IA United StatesDoran & Ward Printing provide printing and packaging services.

5105 Wolff Road Dubuque, IA, 52002 United StatesFounded in 1978 and owned by approximately 1,500 dairy producers across Illinois, Iowa, Minnesota and Wisconsin. Dairy Lab Services continues to test a large volume of samples for DHIA as well as commercial accounts within that service area. Yet, we retain our commitment to detail, accuracy, confidentiality and service to members and customers alike.

3200 Grand Ave Des Moines, IA 50312Mission To improve lives in our global community by educating diverse groups of highly competent and compassionate health professionals. Vision Des Moines University will be: The leader in innovative health education that promotes lifelong learning A cultivator of distinctive faculty and student researchers who discover and disseminate new knowledge A provider of high-quality patient care and educational experiences dedicated to improving health and wellness A policy consultant and resource for those engaged in healthy community transformation

Sioux Center, IA, 51250 United StatesExemplar Genetics offers custom disease model development and production of genetically engineered miniature pig models of human diseases for preclinical research.

P.O. Box 198 Sioux Center, IA 51250 USAExemplar Genetics offers custom disease model development and production of genetically engineered miniature pig models of human diseases for preclinical research.

PO Box 198 United States Sioux Center, IA, 51250 United StatesExemplar Genetics offers custom disease model development and production of genetically engineered miniature pig models of human diseases for preclinical research.

675 44th Street Marion, IA 52302 U.S.AFreund-Vector is a global service provider and manufacturer of granulating, coating and drying equipment.

1115 8th Avenue, Grinnell, IA 50112Founded in 1846, Grinnell College is a private, coed, residential liberal arts and sciences college located in Grinnell, Iowa. We confer bachelor of arts degrees in 26 major fields and offer individualized curriculum planning and advising. Independent majors are possible.

1075 Foster Road Iowa City, IA, 52245 United States When you work with Genezen, we remove the hassles associated with contract work in an academic institution. Our team works with you from early vector design all the way through to producing clinical grade vector. Come to us with your viral vector and testing needs and we will put you with the dedicated experts to move your project forward and ensure you are ready for regulatory scrutiny. We manufacture your vectors in cGMP compliant manufacturing facilities using documented, time tested processes. Additionally we’re able to provide testing services, in dedicated vector testing labs, for your vector and clinical trial samples. All testing is QA reviewed and certificates of analysis are issued for your records. We are also able to compile your clinical trial testing data for periodic reporting, as needed. Just ask, we are here to support you.

2711 South Loop Drive, Suite 4400 Ames, IA 50010 USAHeartland Assays offers a wide variety of analytical services including (but not limited to): Vitamin D, Vitamin D metabolites, Vitamin D binding protein, Vitamins A and E, 3-methylhistidine (3MH), physiological amino acids, β-hydroxy-β-methylbutyrate (HMB), curcumin and curcumin metabolites, hormones, , and protein assays. We strive to achieve the highest quality lab standards and continue to meet the needs of our growing customer base.

Ames, Iowa, 50010Heartland Assays offers a wide variety of analytical services including (but not limited to): Vitamin D, Vitamin D metabolites, Vitamin D binding protein, Vitamins A and E, 3-methylhistidine (3MH), physiological amino acids, β-hydroxy-β-methylbutyrate (HMB), curcumin and curcumin metabolites, hormones, , and protein assays. We strive to achieve the highest quality lab standards and continue to meet the needs of our growing customer base.

0122 Molecular Biology Building, Ames, IA USA new tool for scientific research called the Nano eNablerTM from BioForce Nanosciences, Inc. is available for use in the Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy of the Institute for Combinatorial Discovery. The Nano eNablerTM system is a multifunctional surface patterning platform for dispensing attoliter to femtoliter volumes of biomolecules, nanoparticles and other liquids onto a wide variety of surfaces. The system prints spots and lines from 1 to 60 microns with a 100msec printing cycle, 20 nm stage resolution, 50 mm XY travel and multiplexing ability. This new technology is being applied to a variety of research fields, and the whole spectrum of application of this technology is still being explored. Printable Materials Compatible Surfaces Cell Patterning Biosensor Functionalization Small Volume Biomolecular Assays

2437 Pammel Drive Ames, IA, 50011 United StatesA new tool for scientific research called the Nano eNablerTM from BioForce Nanosciences, Inc. is available for use in the Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy of the Institute for Combinatorial Discovery. The Nano eNablerTM system is a multifunctional surface patterning platform for dispensing attoliter to femtoliter volumes of biomolecules, nanoparticles and other liquids onto a wide variety of surfaces. The system prints spots and lines from 1 to 60 microns with a 100msec printing cycle, 20 nm stage resolution, 50 mm XY travel and multiplexing ability. This new technology is being applied to a variety of research fields, and the whole spectrum of application of this technology is still being explored. Printable Materials Compatible Surfaces Cell Patterning Biosensor Functionalization Small Volume Biomolecular Assays

2610 Beardshear Hall, Ames, IA 50011-2036Three atomic force microscopes are available for use in the Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy of the Institute for Combinatorial Discovery. Digital Instruments DimensionTM 3000 Scanning Probe Microscope The Dimension 3000 scanning probe microscope (SPM) brings together all SPM techniques in a single platform and handles a wide range of sample sizes and types. A rigid, low vibration construction of the Dimension 3000 SPM ensures the highest quality images and measurements. Samples up to eight inches in diameter can be scanned in ambient air or fluids using the Dimension 3000 SPM. The Dimension 3000 SPM requires little or no sample preparation, and the simple vacuum mounting system allows easy and convenient setup. Superior linearity and resolution in all three dimensions are obtained, even for large samples. Integrated top-view video optics with motorized zoom and 1.5 µm optical resolution help identify areas of interest for detailed scanning quickly and easily. Changing scanning techniques, for example from AFM to STM, requires no tools. The NanoScope IIIa system controller is a main part of the SPM system, providing the software and electronics that drive the microscope. Digital tracking and feedback control insure accuracy and speed at all scan sizes and positions on the sample.

515 Morrill Road Ames, IA, 50011 United StatesThree atomic force microscopes are available for use in the Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy of the Institute for Combinatorial Discovery. Digital Instruments DimensionTM 3000 Scanning Probe Microscope The Dimension 3000 scanning probe microscope (SPM) brings together all SPM techniques in a single platform and handles a wide range of sample sizes and types. A rigid, low vibration construction of the Dimension 3000 SPM ensures the highest quality images and measurements. Samples up to eight inches in diameter can be scanned in ambient air or fluids using the Dimension 3000 SPM. The Dimension 3000 SPM requires little or no sample preparation, and the simple vacuum mounting system allows easy and convenient setup. Superior linearity and resolution in all three dimensions are obtained, even for large samples. Integrated top-view video optics with motorized zoom and 1.5 µm optical resolution help identify areas of interest for detailed scanning quickly and easily. Changing scanning techniques, for example from AFM to STM, requires no tools. The NanoScope IIIa system controller is a main part of the SPM system, providing the software and electronics that drive the microscope. Digital tracking and feedback control insure accuracy and speed at all scan sizes and positions on the sample.

1234 Hach Hall, Ames, Iowa 50011-3111The mission of the Chemical Instrumentation Facility (CIF) is to provide analytical instrumentation services and consultation in the areas of Nuclear Magnetic Resonance, Mass Spectrometry, X-Ray Diffraction, Spectrophotometry, and other related areas. These services include operation, training, purchase, and assistance in experimental planning and data interpretation as it pertains to the facility instrumentation. CIF is administered by the Chemistry Department, but exists to support chemical research campus-wide. We typically work with graduate students and other researchers. The primary focus is training students to use our instruments to further their research. In limited cases, we will run samples for researchers. We also assist other academic institutions and Iowa businesses. Fees are charged for use of the instrumentation. ISU Research Park affiliated companies are charged at the external rate.

2438 Pammel Drive Ames, IA, 50011 United StatesThe mission of the Chemical Instrumentation Facility (CIF) is to provide analytical instrumentation services and consultation in the areas of Nuclear Magnetic Resonance, Mass Spectrometry, X-Ray Diffraction, Spectrophotometry, and other related areas. These services include operation, training, purchase, and assistance in experimental planning and data interpretation as it pertains to the facility instrumentation. CIF is administered by the Chemistry Department, but exists to support chemical research campus-wide. We typically work with graduate students and other researchers. The primary focus is training students to use our instruments to further their research. In limited cases, we will run samples for researchers. We also assist other academic institutions and Iowa businesses. Fees are charged for use of the instrumentation. ISU Research Park affiliated companies are charged at the external rate.

0122 Molecular Biology Building Iowa State University Ames, USThe Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy located in the Molecular Biology Building provides an atmosphere for the development of interdisciplinary research between the life and physical sciences. Researchers can use the instrumentation housed in the laboratory to perform optical and scanning force imaging of their samples. Work space is available for students working on projects in the laboratory. In addition, the Carver Lab has a fully equipped cell culture facility and a data processing center where experiments can be analyzed and the results copied onto CDs for use in researchers’ home laboratories.

2437 Pammel Drive Ames, IA, 50011 United StatesThe Roy J. Carver Laboratory for Ultrahigh Resolution Biological Microscopy located in the Molecular Biology Building provides an atmosphere for the development of interdisciplinary research between the life and physical sciences. Researchers can use the instrumentation housed in the laboratory to perform optical and scanning force imaging of their samples. Work space is available for students working on projects in the laboratory. In addition, the Carver Lab has a fully equipped cell culture facility and a data processing center where experiments can be analyzed and the results copied onto CDs for use in researchers’ home laboratories.

2610 Beardshear Hall, Ames, IA 50011-2036The Biomolecular Nuclear Magnetic Resonance (NMR) Facility is supported by the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology. The facility currently operates Bruker Avance II 700 and Avance III 800 spectrometers, each capable of performing a broad range of modern multi-nuclear, multi-dimensional NMR experiments on biomolecules. The 700 is equipped with a 5 mm H/C/N cryoprobe, a 5 mm H/C/BB conventional probe and a 3.2 mm H/BBX/BBY-MAS solids probe. The 800 is equipped with a 5 mm H/C/N cryoprobe, a 5 mm H/C/BB conventional probe and 3.2 mm H/C/N-P and H/C/D solids probes. The facility has computational resources for processing and analyzing NMR data and obtaining molecular structures. The facility provides consultation on the application of NMR to solve research problems. NMR data can be acquired and interpreted as an analytical service. Projects larger in scope can be pursued on a collaborative basis. In the latter case, the facility will provide training and guidance for researchers to operate instruments and interpret data.

515 Morrill Road Ames, IA, 50011 United StatesThe Biomolecular Nuclear Magnetic Resonance (NMR) Facility is supported by the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology. The facility currently operates Bruker Avance II 700 and Avance III 800 spectrometers, each capable of performing a broad range of modern multi-nuclear, multi-dimensional NMR experiments on biomolecules. The 700 is equipped with a 5 mm H/C/N cryoprobe, a 5 mm H/C/BB conventional probe and a 3.2 mm H/BBX/BBY-MAS solids probe. The 800 is equipped with a 5 mm H/C/N cryoprobe, a 5 mm H/C/BB conventional probe and 3.2 mm H/C/N-P and H/C/D solids probes. The facility has computational resources for processing and analyzing NMR data and obtaining molecular structures. The facility provides consultation on the application of NMR to solve research problems. NMR data can be acquired and interpreted as an analytical service. Projects larger in scope can be pursued on a collaborative basis. In the latter case, the facility will provide training and guidance for researchers to operate instruments and interpret data.

2610 Beardshear Hall, Ames, IA 50011-2036The Comparative Pathology Core Service (CPC) provides pathology support services and consultation for investigators working with animal models of human and animal diseases. The veterinary pathologists in the CPC provide gross and microscopic tissue examination, and clinical pathology evaluation. In addition, the core can develop and implement ancillary techniques which include immunohistochemical methods, RNAscope (in situ hybridization), fluorescence microscopy, morphometry and photomicroscopy. CPC costs are based on histopathology lab services and pathologists’ effort. More detailed information can be obtained by contacting the CPC.

515 Morrill Road Ames, IA, 50011 United StatesThe Comparative Pathology Core Service (CPC) provides pathology support services and consultation for investigators working with animal models of human and animal diseases. The veterinary pathologists in the CPC provide gross and microscopic tissue examination, and clinical pathology evaluation. In addition, the core can develop and implement ancillary techniques which include immunohistochemical methods, RNAscope (in situ hybridization), fluorescence microscopy, morphometry and photomicroscopy. CPC costs are based on histopathology lab services and pathologists’ effort. More detailed information can be obtained by contacting the CPC.

1270 Kildee HallThe facility provides a variety of services to individuals who wish to utilize transgenic animals as part of their research program. The facility maintains equipment necessary for the creation of transgenic animals via microinjection or somatic cell nuclear transfer and is available to life science researchers for technical service and for training of a limited number of individuals. All work to be performed in this facility must be scheduled with the professor-in-charge, as the facility is not staffed full-time. Equipment housed in the facility includes two microinjection workstations, micropipette pullers, a microforge, stereo-zoom microscope and CO2 incubator. Additional supporting equipment located in nearby laboratories to which access may be granted includes a heated microcentrifuge, tri-gas incubators, stereo-zoom microscopes, inverted microscope, biosafety cabinet, osmometer, pH meter, embryo freezing machine, cell fusion machine, gel electrophoresis equipment and UV transilluminator.

2610 Beardshear Hall, Ames, IA 50011-2036The facility provides a variety of services to individuals who wish to utilize transgenic animals as part of their research program. The facility maintains equipment necessary for the creation of transgenic animals via microinjection or somatic cell nuclear transfer and is available to life science researchers for technical service and for training of a limited number of individuals. All work to be performed in this facility must be scheduled with the professor-in-charge, as the facility is not staffed full-time. Equipment housed in the facility includes two microinjection workstations, micropipette pullers, a microforge, stereo-zoom microscope and CO2 incubator. Additional supporting equipment located in nearby laboratories to which access may be granted includes a heated microcentrifuge, tri-gas incubators, stereo-zoom microscopes, inverted microscope, biosafety cabinet, osmometer, pH meter, embryo freezing machine, cell fusion machine, gel electrophoresis equipment and UV transilluminator.

515 Morrill Road Ames, IA, 50011 United StatesThe facility provides a variety of services to individuals who wish to utilize transgenic animals as part of their research program. The facility maintains equipment necessary for the creation of transgenic animals via microinjection or somatic cell nuclear transfer and is available to life science researchers for technical service and for training of a limited number of individuals. All work to be performed in this facility must be scheduled with the professor-in-charge, as the facility is not staffed full-time. Equipment housed in the facility includes two microinjection workstations, micropipette pullers, a microforge, stereo-zoom microscope and CO2 incubator. Additional supporting equipment located in nearby laboratories to which access may be granted includes a heated microcentrifuge, tri-gas incubators, stereo-zoom microscopes, inverted microscope, biosafety cabinet, osmometer, pH meter, embryo freezing machine, cell fusion machine, gel electrophoresis equipment and UV transilluminator.

1327 U Avenue, Boone, IowaThe BioCentury Research Farm (BCRF) is the first-in-the-nation integrated research and demonstration facility dedicated to biomass production and processing. It is located seven miles west of the Iowa State University campus on U.S. Highway 30. The BCRF offers opportunities for large pilot and pre-commercial scale research in biomass feedstock production, harvest, transport, storage, preparation, processing and laboratory testing. Field plots for crop production trials, field equipment modification and testing facilities, biomass storage facilities and biomass conversion facilities are available for internal and external users. The biomass processing facility houses three 2,700-square-foot pilot plant processing trains which house biochemical thermochemical processing systems, four laboratories totaling 2,100 square feet, and over 1,400 square feet of office space. The BCRF also has 4,200 square feet of dry biomass feedstock storage and 420 square feet of cold storage.

1327 U Avenue Boone, IA, 50036 United StatesThe BioCentury Research Farm (BCRF) is the first-in-the-nation integrated research and demonstration facility dedicated to biomass production and processing. It is located seven miles west of the Iowa State University campus on U.S. Highway 30. The BCRF offers opportunities for large pilot and pre-commercial scale research in biomass feedstock production, harvest, transport, storage, preparation, processing and laboratory testing. Field plots for crop production trials, field equipment modification and testing facilities, biomass storage facilities and biomass conversion facilities are available for internal and external users. The biomass processing facility houses three 2,700-square-foot pilot plant processing trains which house biochemical thermochemical processing systems, four laboratories totaling 2,100 square feet, and over 1,400 square feet of office space. The BCRF also has 4,200 square feet of dry biomass feedstock storage and 420 square feet of cold storage.

0124 Molecular Biology Building, Iowa State University Iowa, USThe mission of the W.M. Keck Metabolomics Research Laboratory (MRL) is to provide researchers services that enable the high-throughput chemical analysis of metabolites and metabolism. The MRL is equipped with a variety of state-of-the-art analytical instruments that provide researchers with analytical flexibility to analyze a diverse set of metabolites with a variety of chemical and physical properties. The MRL has the capacity to conduct these types of analyses on a 24-hour a day, 7-days a week basis. The establishment of the MRL was made possible by a grant from the W.M. Keck Foundation.

2437 Pammel Drive Ames, IA, 50011 United StatesThe mission of the W.M. Keck Metabolomics Research Laboratory (MRL) is to provide researchers services that enable the high-throughput chemical analysis of metabolites and metabolism. The MRL is equipped with a variety of state-of-the-art analytical instruments that provide researchers with analytical flexibility to analyze a diverse set of metabolites with a variety of chemical and physical properties. The MRL has the capacity to conduct these types of analyses on a 24-hour a day, 7-days a week basis. The establishment of the MRL was made possible by a grant from the W.M. Keck Foundation.

Peosta, IAIBI manufactures electrophoresis equipment, reagents, and other laboratory tools

Peosta, IA, 52068 United StatesIBI manufactures electrophoresis equipment, reagents, and other laboratory tools

109 Seed Science Building Ames, IA, 50011 United StatesThe Iowa State University Seed Testing Laboratory prides itself on offering the most up-to-date and comprehensive services available in the seed-testing industry. Certified seed technologists and analysts with over 157 years of collective experience routinely perform traditional seed tests (warm germs, cold tests, accelerated aging, purity, noxious-weed exam, seed health, etc.) as well as trait tests (herbicide bioassay, ELISA, PCR, and IEF). With more than100 years of excellence in seed testing and customer service, you can rest assured that your samples are in good hands at the ISU Seed Testing Lab.

502 East 9th Street Des Moines, IA, 50319 United StatesThe Food Laboratory is responsible for the testing of meat products produced at locker plants throughout Iowa.

2610 Beardshear Hall, Ames, IA 50011-2036The Fermentation Facility is designed to help researchers develop new fermentation technologies and products and to provide benchtop- and pilot-scale fermentation equipment. The facility has equipment for scaling up the production of industrially important chemicals, chemical feedstocks, genetically modified organisms, and enzymes. The facility gives researchers access to state-of the-art equipment and expertise in the areas of microbial fermentation and product recovery. The Fermentation Facility is a partnership between the Center for Crops Utilization Research, Office of Biotechnology, College of Agriculture and Life Sciences, Department of Food Science and Human Nutrition, Department of Chemical and Biological Engineering, and Bioeconomy Institute.

502 East 9th Street Des Moines, IA, 50319 United StatesThe Dairy Laboratory helps regulate the dairy industry in Iowa by ensuring the safety of the milk supply and keeping the state in compliance with regulations allowing the shipment of milk across state lines.

Iowa State University Ames, IA USThe Microscopy and NanoImaging Facility (MNIF) of the Office of Biotechnology provides a variety of instrumentation, technical assistance, consultation and training to individuals and groups of life sciences and biotechnology researchers who want to use photomacrography, light microscopy, scanning and transmission electron microscopy, cryopreservation, cytochemistry, autoradiography, tomography, x-ray microanalysis and image analysis. In addition to the round-the-clock open hours, the MNIF carries out service work for both on- and off-campus researchers. The director and assistant scientist of the MNIF are available for consultation and individual help. Electron Microscopy Light Microscopy Specialized Rooms Cryostat

Ames, IA, 50011 United StatesThe Microscopy and NanoImaging Facility (MNIF) of the Office of Biotechnology provides a variety of instrumentation, technical assistance, consultation and training to individuals and groups of life sciences and biotechnology researchers who want to use photomacrography, light microscopy, scanning and transmission electron microscopy, cryopreservation, cytochemistry, autoradiography, tomography, x-ray microanalysis and image analysis. In addition to the round-the-clock open hours, the MNIF carries out service work for both on- and off-campus researchers. The director and assistant scientist of the MNIF are available for consultation and individual help. Electron Microscopy Light Microscopy Specialized Rooms Cryostat

2055 Gilman Hall (Keck Lab) Iowa State University Iowa, USThe W. M. Keck Laboratory for the Fabrication of Microminiaturized Analytical Instrumentation (Keck Lab) of the Institute for Combinatorial Discovery provides the ISU and industrial communities with access to state-of-the-art microfabrication technologies. With its approximately 1,000 square feet of class 10/100 clean rooms, the Keck Laboratory supports all phases of microfabrication and its use in fields ranging from analytical chemistry to cell biology. Drawing from affiliates across campus and its resident support staff, expertise in micromechanics, microfluidics, microchip arrays, biology, chemistry, physics and microelectronics can be integrated in translating research ideas into experimental reality. Research capabilities in the laboratory include developing microanalysis systems, chip-scale chromatography, microelectrode assemblies, biochips and cell culture platforms. The laboratory also houses equipment for optical lithography, wet and dry chemical etching and thin film deposition. Analysis and testing equipment, computer workstations and drying and vacuum annealing ovens also are available.

2610 Beardshear Hall, Ames, IA 50011-2036The Atmospheric Air Quality Laboratory, of the Department of Agricultural and Biosystems Engineering, is situated in the new Sukup Hall and serves as a focal point for collaborative research and training in the area of air quality engineering and livestock odor. The laboratory specializes in development and testing of odor and gaseous emissions mitigation technology, continuous air quality monitoring, environmental analysis, quantification of organic compounds with gas chromatography and mass spectrometry, and simultaneous chemical and olfactometry analyses. Livestock odor and gaseous emissions mitigation Air quality monitoring for odor, gases, particulate matter and greenhouse gases at livestock operations Wine flavor, aroma and nutraceuticals Multidimensional GC-MS-olfactometry Solid phase microextraction (SPME) Non-destructive in vivo sampling and analysis of volatiles Biofuels analyses

515 Morrill Road Ames, IA, 50011 United StatesThe Atmospheric Air Quality Laboratory, of the Department of Agricultural and Biosystems Engineering, is situated in the new Sukup Hall and serves as a focal point for collaborative research and training in the area of air quality engineering and livestock odor. The laboratory specializes in development and testing of odor and gaseous emissions mitigation technology, continuous air quality monitoring, environmental analysis, quantification of organic compounds with gas chromatography and mass spectrometry, and simultaneous chemical and olfactometry analyses. Livestock odor and gaseous emissions mitigation Air quality monitoring for odor, gases, particulate matter and greenhouse gases at livestock operations Wine flavor, aroma and nutraceuticals Multidimensional GC-MS-olfactometry Solid phase microextraction (SPME) Non-destructive in vivo sampling and analysis of volatiles Biofuels analyses

1184 Molecular Biology Bldg, 2437 Pammel Drive, Ames, Iowa 50011-1079The DNA Facility of the Iowa State University Office of Biotechnology provides research support services for investigators within academia, industry, and government. The Iowa State University DNA Facility is committed to providing quality service in a consistently rapid, dependable, and economical fashion. Services provided: Genomic DNA Sequencing RNA Sequencing Sanger DNA Sequencing Oligonucleotide Synthesis Fluorescent Genotyping Primer Walking Quantitative & Digital PCR Nucleic Acid Sizing & Quantification 96-Well Plasmid Preparation Plant Tissue Grinding Instrumentation: Illumina HiSeq 2500 & MiSeq Pacific Biosciences PacBio RS II Two Applied Biosystems 3730xl DNA Analyzers BioAutomation MerMade-192 DNA Synthesizer Eight Perkin-Elmer Thermal Cyclers Applied Biosystems StepOnePlus Fluidigm BioMark HD Certiprep GenoGrinder 2000 Agilent 2100 Bioanalyzer AATI Fragment Analyzer The Iowa State University DNA Facility's OnCore online ordering and tracking system allows clients to place orders, track progress of orders, and receive results from the Facility's server 24 hours a day. Once your order is placed, simply print out a copy of your tracking number and mail it with your samples to our facility. When your samples have been processed, you will receive an e-mail notifying you that your data is ready for downloading. Typical turnaround for most of our services is within 2 business days. The Iowa State University DNA Facility is located on the ground floor (Room 1190) of the Molecular Biology Building on Iowa State University's central campus. We are open Monday through Friday 7:30 am to 5 pm to address any questions that you may have concerning your order.

2437 Pammel Drive Ames, IA, 50011 United StatesThe DNA Facility of the Iowa State University Office of Biotechnology provides research support services for investigators within academia, industry, and government. The Iowa State University DNA Facility is committed to providing quality service in a consistently rapid, dependable, and economical fashion. Services provided: Genomic DNA Sequencing RNA Sequencing Sanger DNA Sequencing Oligonucleotide Synthesis Fluorescent Genotyping Primer Walking Quantitative & Digital PCR Nucleic Acid Sizing & Quantification 96-Well Plasmid Preparation Plant Tissue Grinding Instrumentation: Illumina HiSeq 2500 & MiSeq Pacific Biosciences PacBio RS II Two Applied Biosystems 3730xl DNA Analyzers BioAutomation MerMade-192 DNA Synthesizer Eight Perkin-Elmer Thermal Cyclers Applied Biosystems StepOnePlus Fluidigm BioMark HD Certiprep GenoGrinder 2000 Agilent 2100 Bioanalyzer AATI Fragment Analyzer The Iowa State University DNA Facility's OnCore online ordering and tracking system allows clients to place orders, track progress of orders, and receive results from the Facility's server 24 hours a day. Once your order is placed, simply print out a copy of your tracking number and mail it with your samples to our facility. When your samples have been processed, you will receive an e-mail notifying you that your data is ready for downloading. Typical turnaround for most of our services is within 2 business days. The Iowa State University DNA Facility is located on the ground floor (Room 1190) of the Molecular Biology Building on Iowa State University's central campus. We are open Monday through Friday 7:30 am to 5 pm to address any questions that you may have concerning your order.

1800 Christensen Drive Ames , IA , 50011-1134 United StatesThe depth of expertise found in Iowa State University’s Lloyd Veterinary Medical Center is not found anywhere else in the state. We provide the clinical services of highly skilled specialists in the diagnosis and treatment of large and small animal diseases. The medical center provides specialists in anesthesiology, cardiology, dermatology, internal medicine, neurology, oncology, ophthalmology, radiology, reproduction, sports medicine and surgery who can assist in solving difficult medical problems, resulting in a comprehensive therapeutic environment.

2025 Roy J. Carver Co-Laboratory, Iowa State University 1111 WOI Road, Ames, Iowa 50011-1085The Genomic Technologies Facility (GTF), part of the Center for Plant Genomics, provides expertise and equipment to conduct high-throughput research. Our services and equipment include: Next Generation Sequencing Services Ion Torrent™ Proton sequencing Illumina MiSeq sequencing Customized NGS library construction High Throughput Nucleic Acid Manipulation Qiagen BioSprint 96 high-throughput DNA/RNA extraction system Eppendorf AF2200 Plate Reader (absorbance and fluorescence based quantification) Lyophilization and Tissue Grinding PCR Instruments Two MJ Research 384 well 4 block DNA engine tetrads Two Applied Biosystems 384 well 2 block Gene Amp PCR Two RealTime thermocyclers Roche Lightcycler 480 Stratagene Mx4000 Miscellaneous Services and Instruments Single SNP genotyping Blue Pippin and E-gel size selection systems Agilent Bioanalyzer Eppendorf epMotion M5073 liquid handling system

2405 Kooser Drive Ames, IA 50011-3020The Materials Preparation Center (MPC) is a U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering Specialized Research Center located at the Ames Laboratory. MPC is recognized world-wide by the research community for its unique capabilities in preparation, purification, single crystal growth and characterization of rare earth metals, alkaline-earth metals and refractory metal materials. MPC operations are partially supported by the Materials Sciences and Engineering Division as a part of the Synthesis and Processing Science research activity within the Ames Laboratory. Established in 1981, the MPC is a one-of-a-kind facility that is acutely sensitive to the needs of researchers. The facility provides research and developmental quantities of high-purity materials and unique characterization services to scientists at university, industry and government facilities on a cost-recovery basis, allowing access to novel materials and new technologies as they are developed. Renowned for its outstanding technical expertise, the MPC’s alloy preparation and processing capabilities are of great potential value to America’s advancing technology. The MPC provides the personal service required to meet each client’s individual needs. Requests for customized materials and services that are not available from commercial vendors, and are unmatched in quality anywhere else in the world, are provided by the MPC. The range of utilization is demonstrated by the scientific publications in which the MPC and Ames Laboratory are cited.

2405 Kooser Drive Ames, IA, 50011 United StatesThe Materials Preparation Center (MPC) is a U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering Specialized Research Center located at the Ames Laboratory. MPC is recognized world-wide by the research community for its unique capabilities in preparation, purification, single crystal growth and characterization of rare earth metals, alkaline-earth metals and refractory metal materials. MPC operations are partially supported by the Materials Sciences and Engineering Division as a part of the Synthesis and Processing Science research activity within the Ames Laboratory. Established in 1981, the MPC is a one-of-a-kind facility that is acutely sensitive to the needs of researchers. The facility provides research and developmental quantities of high-purity materials and unique characterization services to scientists at university, industry and government facilities on a cost-recovery basis, allowing access to novel materials and new technologies as they are developed. Renowned for its outstanding technical expertise, the MPC’s alloy preparation and processing capabilities are of great potential value to America’s advancing technology. The MPC provides the personal service required to meet each client’s individual needs. Requests for customized materials and services that are not available from commercial vendors, and are unmatched in quality anywhere else in the world, are provided by the MPC. The range of utilization is demonstrated by the scientific publications in which the MPC and Ames Laboratory are cited.

Office of Biotechnology 1210 Molecular Biology Building Ames, IA 50011-3260Iowa State Office of Biotechnology offers service facilities for biotechnological research.

2736 Veterinary Medicine ISU Ames, USThe qPCR Consultation Service provides consultation for comprehensive qPcR assay design assistance. All steps are discussed and/or printed out as easy-to-follow processes for immediate in-lab use. Services Offered: Basic information/qPCR theory and math Primer-probe design assistance Identification of appropriate reagents, master mixes and machine platforms for One- and Two-Step qPCR MIQE-aware methodology and guideline concerns, DNAse treatment and reverse transcription reaction formulation suggestions and guidance Nucleic acid quality assessment and quantity measurement suggestions and guidance Processing of global assay parameters using ISURF software #03407 (PREXCEL-Q) Consultation regarding detection and avoidance of RT and PCR inhibition for all sample types and isolation methods File system creation and initial qPCR test plate set-up printouts and folow-up consultation Processing of test plate results into final set-up parameters and procedural printouts for final sample qPCR Excel spreadsheets custom-created for EAMP-corrected data analysis and graphing All plant and animal species are considered. Fees for services are $90 per hour. Please email or call one week in advance to set up a consultation.

1520 ISU C Drive Ames, IA, 50011 United StatesThe qPCR Consultation Service provides consultation for comprehensive qPcR assay design assistance. All steps are discussed and/or printed out as easy-to-follow processes for immediate in-lab use. Services Offered: Basic information/qPCR theory and math Primer-probe design assistance Identification of appropriate reagents, master mixes and machine platforms for One- and Two-Step qPCR MIQE-aware methodology and guideline concerns, DNAse treatment and reverse transcription reaction formulation suggestions and guidance Nucleic acid quality assessment and quantity measurement suggestions and guidance Processing of global assay parameters using ISURF software #03407 (PREXCEL-Q) Consultation regarding detection and avoidance of RT and PCR inhibition for all sample types and isolation methods File system creation and initial qPCR test plate set-up printouts and folow-up consultation Processing of test plate results into final set-up parameters and procedural printouts for final sample qPCR Excel spreadsheets custom-created for EAMP-corrected data analysis and graphing All plant and animal species are considered. Fees for services are $90 per hour. Please email or call one week in advance to set up a consultation.

0119 Molecular Biology BuildingThe Image Analysis Facility of the Office of Biotechnology provides 2D and 3D imaging resources for researchers interested in sample measurement or visualization. Services include: 2D image analysis (morphometry, particle analysis, densitometry, etc.), 3D image analysis (volumetric sample measurement) and reconstruction, image editing instruction and photomicroscopy. Analysis is performed with IPLab or Imaris software. Equipment in the facility includes: Imaris for 3D reconstruction and image analysis IPLab for 2D image analysis Upright microscope with fluorescence Inverted microscope with fluorescence and DIC Automated scanning stage with recomposition software for capturing images of large samples at high resolution Stereo microscope Digital cameras for all microscopes and copy stand Laser Capture Microdissection System – LCM Laser capture microdissection is a system used to identify and retrieve individual cells from tissue sections. The retrieved cells can be used for assessment/analysis of RNA, DNA, protein and other biochemical properties.

1218 Agronomy Hall | Ames, IA, 50011-1010The development of homozygous lines is an important, but time-consuming process in plant breeding and research. The induction and subsequent doubling of haploids is an efficient alternative to generate homozygous offspring in 2 generations. The Doubled Haploid Facility (DHF) starts in 2010 to provide this service for maize to ISU scientists, but is also open to other academic researchers and breeders. The start-up phase is supported by the Department of Agronomy. The mission of DHF is to: Provide expertise and service in the production of doubled haploid lines in maize Improve the technology in order to get higher success rates and lower costs Teach and train scientists and students

716 Farm House Lane Ames, IA, 50011 United StatesThe development of homozygous lines is an important, but time-consuming process in plant breeding and research. The induction and subsequent doubling of haploids is an efficient alternative to generate homozygous offspring in 2 generations. The Doubled Haploid Facility (DHF) starts in 2010 to provide this service for maize to ISU scientists, but is also open to other academic researchers and breeders. The start-up phase is supported by the Department of Agronomy. The mission of DHF is to: Provide expertise and service in the production of doubled haploid lines in maize Improve the technology in order to get higher success rates and lower costs Teach and train scientists and students

1178 Molecular Biology Building, 2437 Pammel Dr., Ames, IA 50011-1079The Protein Facility provides equipment and expertise for the analysis, characterization and synthesis of proteins and peptides and is open to both internal and external investigators. The Protein Facility is supported by the Office of Biotechnology, the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology and the Plant Science Institute’s Center for Plant Genomics. The following instrumentation is available in the facility: Amersham Pharmacia DALT 2D electrophoresis system Amersham Pharmacia Image Scanner with transparency module Applied Biosystems Model 494 Procise protein/peptide sequencer Applied Biosystems DE-Pro MALDI mass analyzer Beckman System Gold high-performance liquid chromatographs Model 125A Analytical Solvent Module with Model 166 programmable UV detector Model 110A Semi-prep/prep Solvent Module with Model 166 programmable UV detector Model 125S Microanalytical Solvent Module with Model 166 programmable UV detector and SC100 fraction collector Beckman Coulter P/ACE MDQ Capillary Electrophoresis System Biorad minigel and blotting apparatus C.B.S. Scientific spot-picking workstation with UV lightbox GE Healthcare Ettan IPGPhor 3 IEF unit GE Healthcare Typhoon FLA 9500 Scanner Genomics Solutions ProGest NanoDrop ND1000 Spectrophotometer Savant SpeedVac Plus Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer coupled with an Agilent 1260 Infinity Capillary pump Virtis Model 3.5L DBTZL Benchtop FreezeDryer (lyophilizer) Software for the analysis of 1D and 2D gels The following services are offered. High Performance Liquid Chromatography (HPLC) MALDI-TOF Mass Spectrometry Peptide Synthesis Protein/Peptide Sequencing Tandem Mass Spectrometry (LC-MS/MS) In-gel Digestion/Peptide Mass Fingerprinting SDS-PAGE/Electroblotting 2-D Gel Electrophoresis Isoelectric Focusing (IEF) 2-D Gel Analysis Image Scanning and Analysis

2437 Pammel Drive Ames, IA, 50011 United StatesThe Protein Facility provides equipment and expertise for the analysis, characterization and synthesis of proteins and peptides and is open to both internal and external investigators. The Protein Facility is supported by the Office of Biotechnology, the Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology and the Plant Science Institute’s Center for Plant Genomics. The following instrumentation is available in the facility: Amersham Pharmacia DALT 2D electrophoresis system Amersham Pharmacia Image Scanner with transparency module Applied Biosystems Model 494 Procise protein/peptide sequencer Applied Biosystems DE-Pro MALDI mass analyzer Beckman System Gold high-performance liquid chromatographs Model 125A Analytical Solvent Module with Model 166 programmable UV detector Model 110A Semi-prep/prep Solvent Module with Model 166 programmable UV detector Model 125S Microanalytical Solvent Module with Model 166 programmable UV detector and SC100 fraction collector Beckman Coulter P/ACE MDQ Capillary Electrophoresis System Biorad minigel and blotting apparatus C.B.S. Scientific spot-picking workstation with UV lightbox GE Healthcare Ettan IPGPhor 3 IEF unit GE Healthcare Typhoon FLA 9500 Scanner Genomics Solutions ProGest NanoDrop ND1000 Spectrophotometer Savant SpeedVac Plus Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer coupled with an Agilent 1260 Infinity Capillary pump Virtis Model 3.5L DBTZL Benchtop FreezeDryer (lyophilizer) Software for the analysis of 1D and 2D gels The following services are offered. High Performance Liquid Chromatography (HPLC) MALDI-TOF Mass Spectrometry Peptide Synthesis Protein/Peptide Sequencing Tandem Mass Spectrometry (LC-MS/MS) In-gel Digestion/Peptide Mass Fingerprinting SDS-PAGE/Electroblotting 2-D Gel Electrophoresis Isoelectric Focusing (IEF) 2-D Gel Analysis Image Scanning and Analysis

1041 Food Sciences Building 536 Farm House Lane Iowa State University Ames, Iowa 50011-1054The Center for Crops Utilization Research (CCUR), established in 1984, is a multidisciplinary research, development, and technology transfer program in the College of Agriculture and Life Sciences at Iowa State University. CCUR is focused on new processes, products, and markets for corn, soybeans and other Midwest crops. CCUR explores new food, feed, and non-food industrial uses for agricultural materials, and focuses on problem-oriented research directed at expanding midwestern crop utilization. CCUR's mission would not be possible without its modern pilot plant facilities and research labs. By contracting with CCUR and using the Center's equipment and expertise, commercial participants have found a cost-effective way to test new products and processes without interrupting their own full-scale production systems. Mission To identify, coordinate, facilitate and foster mission-oriented interdisciplinary research (both basic and applied), development, technology transfer, and commercialization activities that will increase and enhance utilization of Midwestern crops, and create new agricultural utilization enterprises in Iowa. Vision No grain or crops should leave the state without “adding value”, Iowa remains the world’s primary source of food and feed ingredients, biofuels and biobased products, and ISU becomes the internationally recognized source of new crop-utilization technologies. Goals Develop new product and process technologies to increase the demand for crops and to stimulate economic development Replace petrochemical-derived products with those derived from agricultural resources (biorenewables) Channel the application of biotechnology to increase end-use value and to enhance grain utilization Transfer new technologies to the private sector and encourage successful commercialization

3167 NSRIC 1029 North University Boulevard Ames, IA 50011-3611​The Iowa Grain Quality Initiative (IGQI) is a cutting edge grain quality research and information program. The interdisciplinary project performs the "rapid response function" at ISU for the grain industry. Through diverse expertise of affiliated faculty and the use of information technology, the project has addressed grain production and processing topics quickly, giving producers and agribusinesses the information needed to make business decisions. Challenges related to genetically modified grains have accelerated the use of alternative delivery systems. Rapid response issues IGQI addressed over the past years included: Genetically modified grains (StarLink™ corn, Roundup Ready® corn, and international markets) Frost damage, discoloration, and diseases in corn and soybeans A major farmers cooperative bankruptcy Program and information resources have been promoted and distributed through: Providing Extension field staff with presentation materials for local meetings Outreach meetings Print and electronic media articles Posting reference materials for the media.

2610 Beardshear Hall, Ames, IA 50011-2036The Genome Informatics Facility serves as a centralized resource of expertise on the application of emerging sequencing technologies and open source software as applied to biological systems. Its mission is to integrate this knowledge into pipelines that are easy to understand and use by faculty, staff and students to enable the transformation of ‘big data’ into data that dramatically accelerates our understanding of biology and evolutionary processes. Contact us at gifhelp@iastate.edu if you have a project that needs analysis or want a review of your grant bioinformatic methods text. More information about our services can be found on this page. Andrew Severin Genome Informatics Facility Manager Our Vision Our vision for bioinformatics is to build relationships between scientists and bioinformaticians that enable us to gain insight into interesting biological questions and solve some of the most pressing biological problems facing our world.

515 Morrill Road Ames, IA, 50011 United StatesThe Genome Informatics Facility serves as a centralized resource of expertise on the application of emerging sequencing technologies and open source software as applied to biological systems. Its mission is to integrate this knowledge into pipelines that are easy to understand and use by faculty, staff and students to enable the transformation of ‘big data’ into data that dramatically accelerates our understanding of biology and evolutionary processes. Contact us at gifhelp@iastate.edu if you have a project that needs analysis or want a review of your grant bioinformatic methods text. More information about our services can be found on this page. Andrew Severin Genome Informatics Facility Manager Our Vision Our vision for bioinformatics is to build relationships between scientists and bioinformaticians that enable us to gain insight into interesting biological questions and solve some of the most pressing biological problems facing our world.

1104 Molecular Biology Building • Ames, IA 50010The Hybridoma Facility of the Iowa State University Office of Biotechnology serves the needs of the ISU community as a full service antibody facility. Although we exist for ISU, we also serve the non-ISU community as well. It is for the non-ISU community we have developed these web pages outlining our services, how to contact us, and the general procedures used in the lab. We have done projects for commercial companies as well as research labs at other non-profit institutions.

2437 Pammel Drive Ames, IA, 50011 United StatesThe Hybridoma Facility of the Iowa State University Office of Biotechnology serves the needs of the ISU community as a full service antibody facility. Although we exist for ISU, we also serve the non-ISU community as well. It is for the non-ISU community we have developed these web pages outlining our services, how to contact us, and the general procedures used in the lab. We have done projects for commercial companies as well as research labs at other non-profit institutions.

Iowa State University 0202 MBB Ames, IA 50011The Macromolecular X-ray Crystallography Facility at Iowa State University provides a Rigaku/MSC rotating anode generator for single crystal X-ray diffraction studies, training in crystallography techniques, and a computer lab equipped with crystallography software. Facility services are provided on a fee basis and include consultation on protein purification, crystallization, and crystal optimization, as well as assistance with crystal screening, data collection, data processing, and structure determination and analysis.

2610 Beardshear Hall, Ames, IA 50011-2036The Confocal and Multiphoton Facility of the Office of Biotechnology provides confocal and multiphoton instrumentation and training for internal and external researchers. Confocal microscopes remove out-of-focus fluorescent light from the image, allowing clearer imaging of the sample, including the ability to view structures and components that were obscured by excess fluorescence that would be generated by standard fluorescence microscopes. Some applications of confocal microscopy include fluorescence microscopy when spatial distribution of cellular or other structures is important to the research being conducted, acquisition of a stack of images that can be used for 3D-reconstruction, viewing structures in thick tissue and removing background and cross-talk fluorescence or fluorescence from other structures that obscure viewing of the desired structure. The confocal microscope in the Confocal and Multiphoton Facility allows for real-time optical sectioning of fixed and living specimens, providing significant improvements in optical contrast and resolution over traditional light and fluorescence microscopy. The facility is equipped with a Leica SP5 X MP confocal/multiphoton microscope system with an inverted microscope front end. New technology available on this system includes a white light laser, IR laser and optical parametric oscillator (OPO). Researchers are no longer limited to three or four lasers at three or four fixed wavelengths but can tune the white light laser to any wavelength between 470 and 670 nm, which has a similar effect to having 200 lasers and 200 wavelengths. This allows researchers to select the excitation wavelength that is best suited to their samples and will result in maximum fluorescence emission. On the emission side, the system has an Acousto-Optical Beam Splitter (AOBS) which allows researchers to precisely set the emission wavelengths they would like to capture rather than be limited to preset emission ranges determined by fixed filter sets. Both of these technologies help to separate fluorescence signals with close excitation and/or emission spectra.

515 Morrill Road Ames, IA, 50011 United StatesThe Confocal and Multiphoton Facility of the Office of Biotechnology provides confocal and multiphoton instrumentation and training for internal and external researchers. Confocal microscopes remove out-of-focus fluorescent light from the image, allowing clearer imaging of the sample, including the ability to view structures and components that were obscured by excess fluorescence that would be generated by standard fluorescence microscopes. Some applications of confocal microscopy include fluorescence microscopy when spatial distribution of cellular or other structures is important to the research being conducted, acquisition of a stack of images that can be used for 3D-reconstruction, viewing structures in thick tissue and removing background and cross-talk fluorescence or fluorescence from other structures that obscure viewing of the desired structure. The confocal microscope in the Confocal and Multiphoton Facility allows for real-time optical sectioning of fixed and living specimens, providing significant improvements in optical contrast and resolution over traditional light and fluorescence microscopy. The facility is equipped with a Leica SP5 X MP confocal/multiphoton microscope system with an inverted microscope front end. New technology available on this system includes a white light laser, IR laser and optical parametric oscillator (OPO). Researchers are no longer limited to three or four lasers at three or four fixed wavelengths but can tune the white light laser to any wavelength between 470 and 670 nm, which has a similar effect to having 200 lasers and 200 wavelengths. This allows researchers to select the excitation wavelength that is best suited to their samples and will result in maximum fluorescence emission. On the emission side, the system has an Acousto-Optical Beam Splitter (AOBS) which allows researchers to precisely set the emission wavelengths they would like to capture rather than be limited to preset emission ranges determined by fixed filter sets. Both of these technologies help to separate fluorescence signals with close excitation and/or emission spectra.

1104 Molecular Biology Building Ames, IA 50011Iowa State University's Flow Cytometry Facility offers life scientists a powerful technology for investigating all aspects of cell biology and for isolating cells of interest. Flow cytometry is an indispensable tool for deciphering complex cellular processes and interactions in a variety of animal, plant and microbial systems; enabling detection and quantitative analysis of specific cellular and sub-cellular elements in a complex mixture of cells. Our mission is to promote scientific research by making flow cytometry instrumentation and expertise available to both the University community and off-campus institutions. We have three state of the art flow cytometers, as well as a number of other research related instruments, and we are experienced in applications for animal cells, plant cells and bacteria. Investigators from all over the world employ our facility to sort discrete cell populations and gather data on cell-surface/intercellular protein expression, chromosomal ploidy, cell concentration, gene expression, proliferation, apoptosis, and a number of other cell-related properties. Flow cytometry is continually expanding in scope as a research tool and your most valuable technical resource is the staff of the Flow Cytometry Facility. We are here to consult on experimental design and assist in data acquisition and analysis and we strive to stay abreast of the latest techniques. Contact us to find out how flow cytometry can help facilitate your research.

2437 Pammel Drive Ames, IA, 50011 United StatesIowa State University's Flow Cytometry Facility offers life scientists a powerful technology for investigating all aspects of cell biology and for isolating cells of interest. Flow cytometry is an indispensable tool for deciphering complex cellular processes and interactions in a variety of animal, plant and microbial systems; enabling detection and quantitative analysis of specific cellular and sub-cellular elements in a complex mixture of cells. Our mission is to promote scientific research by making flow cytometry instrumentation and expertise available to both the University community and off-campus institutions. We have three state of the art flow cytometers, as well as a number of other research related instruments, and we are experienced in applications for animal cells, plant cells and bacteria. Investigators from all over the world employ our facility to sort discrete cell populations and gather data on cell-surface/intercellular protein expression, chromosomal ploidy, cell concentration, gene expression, proliferation, apoptosis, and a number of other cell-related properties. Flow cytometry is continually expanding in scope as a research tool and your most valuable technical resource is the staff of the Flow Cytometry Facility. We are here to consult on experimental design and assist in data acquisition and analysis and we strive to stay abreast of the latest techniques. Contact us to find out how flow cytometry can help facilitate your research.

601 Highway 6 West Iowa City, IA 52246Since 1952, the Iowa City VA Health Care System has been improving the health of the men and women who have so proudly served our nation. We consider it our privelege to serve your health care needs in any way we can. Services are available to more than 184,000 veterans living in 50 counties in Eastern Iowa, Western Illinois and Northern Missouri.

601 Highway 6 West Iowa City, IA, 52246 United StatesSince 1952, the Iowa City VA Health Care System has been improving the health of the men and women who have so proudly served our nation. We consider it our privelege to serve your health care needs in any way we can. Services are available to more than 184,000 veterans living in 50 counties in Eastern Iowa, Western Illinois and Northern Missouri.

1184 Molecular Biology Building Ames, Iowa 50011-3260Iowa State University provides metagenomics, genotyping, microarray, and sequencing services.

Ames, IA United StatesIowa State University provides metagenomics, genotyping, microarray, and sequencing services.

345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317 USAJones Microbiology Institute (JMI) Laboratories provides anti-infectives research and trial support.

P.O. Box 130 Shenandoah, Iowa 51601 USALLOYD manufactures and develops pharmaceutical and nutritional products for animals.

700 College Drive Decorah, Iowa 52101 USA Located in the vibrant town of Decorah in northeastern Iowa, Luther is an undergraduate liberal arts college affiliated with the Lutheran Church (ELCA). A Place of Welcome Founded in 1861 by Norwegian immigrants, Luther values its heritage, just as it values the diversity of its students, staff, and faculty, who hail from many faith backgrounds and heritages. The college strives to make Luther affordable for all students by offering scholarships, need-based aid, work study, and loan programs. Academic Excellence Luther offers more than 60 majors and preprofessional programs leading to the bachelor of arts degree. The college’s learning philosophy highlights connections between disciplines. Its thoughtful and rigorous curriculum moves beyond immediate interests toward engagement in the larger world.

700 College Drive Decorah, Iowa, 52101 United States Located in the vibrant town of Decorah in northeastern Iowa, Luther is an undergraduate liberal arts college affiliated with the Lutheran Church (ELCA). A Place of Welcome Founded in 1861 by Norwegian immigrants, Luther values its heritage, just as it values the diversity of its students, staff, and faculty, who hail from many faith backgrounds and heritages. The college strives to make Luther affordable for all students by offering scholarships, need-based aid, work study, and loan programs. Academic Excellence Luther offers more than 60 majors and preprofessional programs leading to the bachelor of arts degree. The college’s learning philosophy highlights connections between disciplines. Its thoughtful and rigorous curriculum moves beyond immediate interests toward engagement in the larger world.

2631 Grandview Ave.Microbac Laboratories, Inc. is a full-service contract laboratory (cGMP and GLP) offering: Microbiology, Analytical Chemistry,and Virology testing. Other tests: Stability, Environmental Monitoring, and Elemental Analysis. Industries serviced: Pharmaceutical, Biotech, Generics, Cosmetics, and OTC. Microbac will work as the contracted laboratory supporting laboratory testing services in preparation for filing the IND - NDA, BLA and ANDA Submissions.

100 Grand Vue Plaza, Suite 22Microbac Laboratories, Inc. is a full-service contract laboratory (cGMP and GLP) offering: Microbiology, Analytical Chemistry,and Virology testing. Other tests: Stability, Environmental Monitoring, and Elemental Analysis. Industries serviced: Pharmaceutical, Biotech, Generics, Cosmetics, and OTC. Microbac will work as the contracted laboratory supporting laboratory testing services in preparation for filing the IND - NDA, BLA and ANDA Submissions.

1833-A 57th STOsprey Biotechnics offers fermentation services.

303, Devarc Commercial Building,Oncology Services offers phase I-IV clinical research services, regulatory affairs, consulting, data management, quality assurance, and pharmacovigilance.

451 Black Forest Rd, Hull, IA 51239

ISU Research Park 2501 N. Loop Drive, Suite 1600 Ames, IA, 50010 USAPK Biosciences offers a wide range of assays and in-vivo/in-vitro toxicity testing.

1000 Brady Street Davenport, IA 52803The Laboratory Animal Resource Facility provides general animal care services related to basic science research projects. It operates under the guidance of the Palmer Institutional Animal Care and Use Committee and maintains an animal facility meeting the highest standards of animal care. Licensed and inspected by the United States Department of Agriculture and the Iowa Department of Agriculture, the Laboratory Animal Resource Facility assures that the care and use of animals is scientifically, technically and humanely appropriate.

1000 Brady Street Davenport, IA, 52803 United StatesThe Laboratory Animal Resource Facility provides general animal care services related to basic science research projects. It operates under the guidance of the Palmer Institutional Animal Care and Use Committee and maintains an animal facility meeting the highest standards of animal care. Licensed and inspected by the United States Department of Agriculture and the Iowa Department of Agriculture, the Laboratory Animal Resource Facility assures that the care and use of animals is scientifically, technically and humanely appropriate.

620 Country Club Road Iowa Falls, IA, 50126 United StatesOUR MISSION Pinnacle, a comprehensive agronomic and environmental consulting firm, has years of experience in environmental and regulatory compliance. Our mission is to offer our knowledge and experience in environmental and regulatory compliance for livestock producers. OUR SERVICE Pinnacle helps the farmer work through the permitting process for new facilities and stay up to date and in compliance with DNR with their manure management plans.

17048 215th Street Davenport, IA 52806

204 Lange DriveRD Laboratories offers wet chemical, stability testing, chromatography, spectrophotometry, and optical rotation services.

1829 Highway 1, Fairfield, IA, 52556 USASopharmia offers drug resistant bacterial infections.

Fairfield, IA United StatesSopharmia offers drug resistant bacterial infections.

U.S. 6 United StatesShanghai Haoyuan Chemexpress specializes in custom synthesis of organic compounds and supplies fine chemicals, pharmaceutical intermediates, and API derivatives.

2650 Murray St. Sioux City, IA 51111SADEX Corporation is a Texas-based corporation operating an electron beam (“e-beam”) irradiation or “cold pasteurization” facility in Sioux City, Iowa. SADEX provides cold pasteurization services to the food and agricultural industries utilizing proprietary, patented technology that eliminates pathogens without the use of radioactive or chemical agents. Operating under the SADEX banner since 2005, the corporation’s clients are some of the best known names in food processing, animal health, feed processing, marketing and distribution.

548 Canning StreetSciMetrics offers data modeling, analysis, and presentation for the medicinal, toxicological, a

1207 Lucas Avenue Burlington, IA, 52601 United StatesTjaden Biosciences offers custom radiosynthesis services.

5700 University Avenue West Des Moines, IA, 50266 United StatesOur Business Plant genetics research and development enabling exclusive "Private Label" seed products. The Heart of What We Do We do COMMERCIAL research and product development. We specialize in creating, developing and producing commercial maize hybrids for agricultural seed companies to sell exclusively under their own brands. Mission To improve our world through plant genetics and technology by being an industry leader in creating, developing and producing premium quality agricultural seeds for companies globally. Operating Principles Maintain the highest levels of integrity, honesty and trust by applying the highest moral, ethical and legal principles and standards to all activities To be an industry leader in providing value and customer satisfaction Continually invest resources in learning and developing the latest technologies to better adapt to changing demands and customer needs Project a positive force in the global community

2938 380th Street Sioux Center, IA 51250 USATrans Ova Genetic offers reproductive technologies such as embryo transfer, in-vitro fertilization (IVF), sexed-semen, genetic preservation and cloning to support cattle breeders.

Sioux Center, IA, 51250 United StatesTrans Ova Genetic offers reproductive technologies such as embryo transfer, in-vitro fertilization (IVF), sexed-semen, genetic preservation and cloning to support cattle breeders.

Iowa City, IA United StatesUniversity of Iowa Pharmaceuticals offers formulation development, preformulation study, API and excipient release testing services.

108 River St, Iowa City Iowa, USAUniversity of Iowa performs academic research.

Iowa City IA, 52242 United StatesUniversity of Iowa performs academic research.

1920 Dayton Ave. Ames, IA, 50010 United StatesMission: The National Veterinary Services Laboratories (NVSL) safeguard U.S. animal health and contribute to public health by ensuring that timely and accurate laboratory support is provided by their nationwide animal-health diagnostic system. NVSL staff accomplish this through: Providing diagnostic services, reagents, and training in world-class facilities Responding to animal health emergencies Taking an active role in managing the National Animal Health Laboratory Network (NAHLN) Serving as an international reference laboratory Maintaining a well-trained and responsive staff

Iowa City, Iowa, 52242 United StatesUniversity of Iowa Radiation and Free Radical Research Core focuses on providing state of the art technologies to investigators studying the role of oxidative stress and redox biology.

431 Newton Road Iowa City, IA, 52242 United StatesThe mission of the Viral Vector Core is to produce and distribute quality viral vectors to the research community. We are a full service facility and can aid investigators in the design and construction of a wide variety of custom viral vectors. The Viral Vector Core is a non-profit facility that produces vectors on a fee-for-service basis to investigators world-wide. The vector core has a large catalog of “off the shelf” vectors available to investigators on demand without the need of a material transfer agreement (MTA). In addition, there are a great number of published reagents that are available with permission of the generating principal-investigator. In this case, vectors and plasmids are available with an appropriate MTA.

500 Newton Road, 221 EMRB Iowa City, IA, 52242 United StatesThe mission of the Viral Vector Core is to produce and distribute quality viral vectors to the research community. We are a full service facility and can aid investigators in the design and construction of a wide variety of custom viral vectors. The Viral Vector Core is a non-profit facility that produces vectors on a fee-for-service basis to investigators world-wide. The vector core has a large catalog of “off the shelf” vectors available to investigators on demand without the need of a material transfer agreement (MTA). In addition, there are a great number of published reagents that are available with permission of the generating principal-investigator. In this case, vectors and plasmids are available with an appropriate MTA.

Tissue Procurement Core Facility University of Iowa Carver College of Medicine 500 Newton Road – 380 MRC Iowa City, IA 52242The Tissue Procurement Core (TPC) Facility is jointly supported the Carver College of Medicine (CCOM) and the Holden Comprehensive Cancer Center (HCCC). The goal of the TPC is to make well-characterized human biospecimens (tissue, blood, etc.) available for current research studies and to store frozen human biospecimens (usually tumor and normal tissues, blood, and derivatives) for future research studies. Stored biomaterials are suitable for molecular genetic, biochemical and pathological studies.

2121 Second StreetVitalea Science applies accelerated mass spectrometry to offer bioavailibility studies, ADME, biologics, metabolite profiling and microdosing services.

21459 Old Hwy. 6 Adel, Iowa, 50003 United StatesVALO BioMedia is a global supplier of Vaccine Eggs used in the production of human and animal vaccines and in pharmaceutical research. We are the largest supplier of SPF Eggs in Europe and in the top two globally. In the production of Clean Eggs VALO BioMedia is the world leader.

310 W. Zeller St NORTH LIBERTY, IA, 52317 United StatesViraQuest provides adenoviral vector production services.

1290 West, 2320 South, Ste DVioGen Biosciences offers expertise in medicinal chemistry, custom synthesis, and chemical analysis services.

31552 Delta Ave Manning, Iowa, 51455 United StatesWiese & Sons LLP is committed to improving the land for future generations, which has been an important challenge to enhance the quality of life for not only our family and cattle herd, but our community as well.

West Liberty, IA, 52776 United StatesIn 1943, Louis H. Rich established the Rock Island Produce Company from Rock Island, Illinois, to West Liberty, Iowa. By 1946, the plant was converted to a chicken slaughter facility. Martin and Norman Rich, both sons of Louis, decided the company would undergo a massive revamp, and thus in 1949 the company began focusing on turkey products. In 1960, The Rock Island Produce Company changed their name to Louis Rich Foods, Inc. and undertook the first expansion of the West Liberty facility. 19 years later, in 1979, the company was acquired by Oscar Mayer, General Foods, and Phillip Morris. The facility ran until 1996, when Oscar Mayer, a division of Phillip Morris, announced they were closing the West Liberty facility effective December 31. At that time, the Iowa Turkey Growers Cooperative (ITGC) was formed by 47 Iowa-based turkey growers. ITGC purchased the West Liberty, Iowa facility and began to run their business as West Liberty Foods. In 1997, the first turkeys were processed by the Cooperative. Three years later, in 2000, West Liberty Foods purchased a facility in Sigourney, Iowa. That facility was sold in late 2012. In 2002, the USDA-inspected Research and Development Center was opened in West Liberty, Iowa. One year later, the Mount Pleasant, Iowa facility was opened and then expanded in 2004. By 2005, West Liberty Foods opened a state-of-the-art Quality Assurance Laboratory in West Liberty. Only four years after the opening of the Mount Pleasant, Iowa plant, West Liberty Foods expanded towards the west by building and opening a new facility in Tremonton, Utah in 2007. In 2008 the Hearts & Hands Children's Academy opened in Tremonton, Utah. In 2012 West Liberty Foods became a Landfill Free Company. All three facilities were independently verified by NSF International Strategic Registrations in which West Liberty Foods demonstrated that less than 1% of all waste is being sent to a landfill. The company’s combined total saved waste is 7.5 million lbs annually and they are one of the first companies in the United States to have this claim verified by a third-party organization. In 2013, High Pressure Pasteurization systems were installed in the Mount Pleasant, Iowa and Tremonton, Utah facilities. In 2014 West Liberty Foods purchased a fourth manufacturing facility in Bolingbrook, IL.

1 Wacker Drive Eddyville, IA 52553 United StatesWacker offers contract manufacturing, biologic analysis, and quality control/assurance services.

1800 Christensen Drive Bms 1072 Ames, IA, 50010 United States3D Health Solutions provides canine (intestine, bladder, pancreas, kidney, lung, and liver), among other organoids for pharma and nutritional research to Boehringer Ingelheim, Nestle, and numerous other leading pharma and nutrition companies. We operate either as a CRO or license research models of differing phenotypes including disease models. We have recently completed a 5-year research cooperation agreement with the FDA, and have also received funding from the NIH and NCI. We would appreciate an opportunity to present our research capabilities to your team.